| 1 | EDITORIAL |
| 2-10 | Controlled Release of Polypeptides and Other Macromolecules | Ronald A. Siegel and Robert Langer |
| 11-18 | The Potential of Nucleotide Analogs as Inhibitors of Retroviruses and Tumors | Roland K. Robins |
| 19-23 | New Lipophilic Terbutaline Ester Prodrugs with Long Effect Duration | O. A. Torsten Olsson and Leif-Å. Svensson |
| 23-27 | Influence of Bloodflow on the Absorption of Theophylline from the Jejunum of the Rat | Norbert Schurgers and Cornelis J. de Blaey |
| 28-32 | The Hypolipidemic Activity of N-(p-Chlorobenzoyl)-sulfamate in Rodents and its Effect on Lipid Metabolism | I. H. Hall, S. D. Wyrick, P. J. Voorstad and A. Dubey |
| 33-38 | Pharmacokinetics of Anthracyclines in Dogs: Evidence for Structure-Related Body Distribution and Reduction to Their Hydroxy Metabolites | Marijn J. M. Oosterbaan, Rita J. M. Dirks, Tom B. Vree and Eppo van der Kleijn |
| 39 | The Analgesic Activity of Neo-Kyotorphin: A Newly Identified Pentapeptide from Bovine Brain. | Kiyoshi Fukui, Hiro Amano, Yoshiaki Kiso, Kouki Kitagawa and Hiroshi Takagi |
| 40-43 | Continuous Measurements of ATP Secretion in Vivo | J. Bryan Smith, Sandra E. Burke, Allan M. Lefer and Arthur Freilich |
| 43-45 | High Pressure Liquid Chromatographic Analysis of Metoclopramide in Serum | Jordan L. Cohen, Gordon H. Jonathan E. Hisayasu and Stephen B. Strum |
| 46-48 | WIN 44,441: A Stereospecific and Long-Acting Narcotic Antagonist | Paul L. Wood, Carmencita Pilapil, Mira Thakur and Jean W. Richard |
| 49 | Factors Affecting the Determination of Unbound Carbamazepine Concentrations in Plasma | J. J. H. M. Lohman, F. W. H. M. Merkus, G. M. P. J. Costongs, E. P. J. M. H. Hegtermans and P. M. Hooymans |
| 50 | Who Speaks for the Future? | Jere E. Goyan |
| 189-194 | Extraction of Natural Substances with Dense Gases | Egon Stahl and Karl Werner Quirin |
| 194-203 | Pyrazolopyrimidine Metabolism in Parasitic Protozoa | Buddy Ullman |
| 203-209 | Pharmacokinetics and Metabolic Fate of Two Nitroxides Potentially Useful as Contrast Agents for Magnetic Resonance Imaging | William R. Couet, Ulf G. Eriksson, Thomas N. Tozer, L. Dallas Tuck and George E. Wesbey, et al. |
| 209-214 | Radioreceptor Assay of Narcotic Analgesics in Serum | Joachim Grevel, Jeff Thomas, Mark L. Richards and Wolfgang Sadée |
| 215-220 | A Radioimmunoassay for Determination of Glibenclamide and Other Sulfonylureas | Wolfgang Heptner, Mario Badian, Siegfried Baudner, Christa Hellstern and Robert Irmisch, et al. |
| 221-224 | Transmucosal Passage of Liposomally-Entrapped Drugs in Rat Small Intestine | Toshikiro Kimura, Kazutaka Higaki and Hitoshi Sezaki |
| 225-229 | Antipyrine - New Light on an Old Drug | Hartmut Derendorf, Gertrude Drehsen and Peter Rohdewald |
| 229-231 | Prostaglandin E1-induced Catalepsy in the Rat: Role of Putative Neutrotransmitters | Salil K. Bhattacharya, Patchala J. Mohan Rao and Dipankar Bhattacharya |
| 231-233 | Morphine Inhibition of Theophylline Clearance | Mario L. Rocci, Parviz Mojaverian and Consuelo L. Saccar |
| 234-235 | Delayed Ethanol Elimination in Rats after Application of Cefamandole or Cefoperazone | Klaus G. Römer, Klaus J. Freundt, Oscar Torres Alanis and Graciela Garcia de Torres |
| 236 | BOOK REVIEWS |
| 237-244 | Drug Delivery by Program or Sensor Controlled Infusion Devices | Manfred Franetzki |
| 245-249 | Effect of Column Temperature and Eluent Flow Rate on the High Performance Liquid Chromatographic Analysis of Cyclosporin A and D | Kulthoum A. Mereish and Clarence T. Ueda |
| 250-255 | The Hypolipidemic Activity of 3-Iminophthalimidine in Rodents | P. Josée Voorstad, George H. Cocolas and Iris H. Hall |
| 256-259 | Effect of Entrapped Markers on the in situ Jejunal Uptake from Liposomal Systems | D. L. Schwinke, M. G. Ganesan and Norman D. Weiner |
| 259-266 | Relationship of Octanol/Water Partition Coefficient and Molecular Weight to Cellular Permeability and Partitioning in S49 Lymphoma Cells | Victor A. Levin, Doug Dolginow, Herbert D. Landahl, Craig Yorke and Judit Csejtey |
| 267-269 | Hypolipidemic Agents of Phthalimide Derivatives 6. Effects of Aromatic vs. Non-Aromatic Imides | James M. Chapman, Steven D. Wyrick, James H. Maguire, George H. Cocolas and Iris H. Hall |
| 269-271 | In Vitro Antimicrobial Activity of Benzoquinolinediones | Alice M. Clark, Debra L. Huddleston, Cheng Yu Ma and Chuen-Huei Ho |
| 271-274 | Phosphorus GABA Analogues as Potential Prodrugs | Lindley A. Cates and Mohamed S. Rashed |
| 274-276 | In vitro Metabolism of Bumetanide | Giorgio Grosa, Franca Viola, Otto Caputo and Giuseppe Biglino |
| 277-279 | Replacing the Mixed Function Oxidase N-Demethylation by Hydrogen Peroxide and either Hemoglobin or Ferrous Sulfate | Shmuel Zbaida, Dalia Gilhar and Judith Silman-Greenspan |
| 279-282 | Effect of Mangiferin, a Naturally Occurring Glucosylxanthone, on Reproductive Function of Rats | Sukumar Chattopadhyay, Utpala Chattopadhyay, Santyeswar P. Shukla and Shibnath Ghosal |
| 287-288 | Author's Index: Pharmaceutical Research 1984 |
| 289-290 | Subject Index: Pharmaceutical Research 1984 |
| 55-61 | The Molecular Basis of β-Lactamase Catalysis and Inhibition | Anthony L. Fink |
| 61-64 | Drug Release from Suppositories | Cornelis J. de Blaey and Jasper G. Fokkens |
| 65-68 | pH-Solubility Profiles of Organic Bases and Their Hydrochloride Salts | Abu T. M. Serajuddin and Daniel Mufson |
| 69-72 | Pharmacokinetics of Two Prototype Nitroxide Spin Labels for Contrast Enhancement in Magnetic Resonance Imaging | William R. Couet, Ulf G. Eriksson, Robert C. Brasch and Thomas N. Tozer |
| 73-75 | HPLC Analysis of Thimerosal in Ophthalmic Solution. Comparing Electrochemical with Spectrophotometric Detectors | Gary C. Visor, Richard A. Kenley, Jeffrey S. Fleitman, Daniel A. Neu and Irene W. Partridge |
| 75-77 | Studies on the Dissolution of Drugs from Tablets using Perturbed Angular Correlation | Michael Jay, John T. Fell and George A. Digenis |
| 77-80 | The Interaction of Cyanonaphthyridinomycin with DNA | Milton J. Zmijewski and Marcia Mikolajczak |
| 80-83 | Drug Distribution and Biliary Excretion Pattern of a Cyclic Somatostatin Analog: A Comparison of 14C Labeled Drug and a 131I lodinated Drug Analog | Larry J. Caldwell, Alan Parr, Robert M. Beihn, Bushra J. Agha and Arthur R. Mlodozeniec, et al. |
| 83-86 | Effects of 5-Fluorouracil Prodrugs on the Central Nervous System in Mice and Rats | Katsuo Toide, Norio Unemi and Tomio Segawa |
| 87-90 | Differential Inhibitory Effects of Isosorbide Dinitrate and its Mononitrate Metabolites on Platelet Aggregation and Thromboxane Formation | Pierre H. Rolland, José Sampol, Bruno Lacarelle, Dominique Arnoux and François Leca, et al. |
| 90-93 | Evidence for an Acute Antimagnesiuretic Effect of Triamterene Derivatives | Helmut Priewer, Helga Kraft and Ernst Mutschler |
| 94-95 | Verapamil Interacts Stereoselectively with the Muscarinic Receptor | John C. Giacomini, Ray H. Zobrist, Bharati Dave and Kathleen M. Giacomini |
| 96 | Announcements |
| 151-156 | Peptides and Proteins as Drugs | Bobbe L. Ferraiolo and Leslie Z. Benet |
| 156-162 | Sympathomimetic Bronchodilators: Increased Selectivity with Lung-Specific Prodrugs | Leif Å. Svensson |
| 162-165 | Absorption of Etoposide (VP-16-213) from the Small Intestine of the Rat. The Potential Role of Mucus as an Absorption Rate Limiting Barrier | N. Schurgers, Cornelis J. de Blaey and D. J. A. Crommelin |
| 166-170 | Absorption and Bioavailability of Diclofenac after Rectal Administration of Diclofenac-Na Gel Preparation in Rat and Man | Kazuhiro Morimoto, Yoko Iwamoto, Takao Katashima, Toshiyuki Takeeda and Yasuo Nakamoto, et al. |
| 170-175 | Adsorption and Chemical Stability of a Cationic Aggregating Ester – Propantheline Bromide – on Silica Surfaces in Aqueous Dispersions | Rolf Daniels and Herbert Rupprecht |
| 176-177 | The Pharmacokinetics of Amrinone at Three Dose Levels in the Rabbit | Ghassem E. Larijani, Mario L. Rocci, Deborah L. Newman and Hugh Wilson |
| 178-181 | Buprenorphine is an Antagonist at the ϰ Opioid Receptor | Mark L. Richards and Wolfgang Sadée |
| 181-184 | A New Method for the Determination of Partition Coefficients of Air Sensitive Copper(I) Complexes | Hans-Dieter Gaisser, Henk van der Goot and Henk Timmerman |
| 185-187 | Mandibular and Parotid Salivary Levels of Indomethacin Following Intravenous Administration to Rabbits | Jun Watanabe, Tsutomu Setoyama, Kikuo Iwamoto, Yayoi Hayashi and Shoji Ozeki |
| 188-191 | Pharmacokinetics of Pirazolac – a New Anti-Inflammatory Drug – in Human Volunteers II. Dose Linearity of Plasma Levels and Excretion | Ulrich Täuber, Christian Weiss and Heinz Matthes |
| 192-194 | Structure of a Neurotoxin that Induces Parkinsonism Symptoms; l-Methyl-4-phenyl-l,2,3,6-tetra-hydropyridine Hydrochloride | Cheryl L. Klein, Ronald F. Borne and Edwin D. Stevens |
| 195-198 | Prostaglandins and Central Serotonergic Activity in the Rat | Salil K. Bhattacharya |
| 198-202 | Effect of Dextran on the Release of Gonadotropin-Releasing Hormone (GnRH) Injected into Rats: Plasma GnRH and Gonadotropin Response | Nadja Heinrich, Dorothea Lorenz, Hartmut Berger, Klaus Fechner and Hermann Eberhard Schmidt, et al. |
| 202-206 | Cutaneous Absorption of Indomethacin From Two Topical Preparations in Volunteers | Hans Nowack, Udo Marin, Raimund Reger, Herta Böhme and Karl-H. Schriever, et al. |
| 206-211 | Kinetic Analysis of Transdermal Nitroglycerin Delivery | Richard H. Guy and Jonathan Hadgraft |
| 211-217 | Computer Modeling of the Pharmacokinetics of Fluorouracil and Thymine and Their Kinetic Interaction in Normal Dogs | Joseph M. Covey and James A. Straw |
| 217-220 | Inosine Analogs as Anti-Leishmanial Agents | Petrie Rainey, Patricia A. Nolan, Leroy B. Townsend, Roland K. Robins and Jack J. Fox, et al. |
| 221-224 | In Situ Intestinal Absorption of a Poorly Water-Soluble Drug From Mixed Micellar Solutions of Bile Salt and Lipolysis Products in Rats | A.T.M. Serajuddin, M. Rosoff and A.H. Goldberg |
| 225-230 | Thermodynamics of Distribution of Salicylates in Semi-Solid Ointment Bases | Stanley S. Davis, Khalil Al-Khamis and Jonathan Hadgraft |
| 231-233 | Excretion of Metabolites in Bile Following the Administration of Primaquine to Rats | John K. Baker, James D. McChesney and Larry A. Walker |
| 233-238 | The Hypolipidemic Activity of Furoic Acid and Furylacrylic Acid Derivatives in Rodents | Iris H. Hall, Wallace L. Williams Jr, Kathryn A. Rhyne and Margaret Knowles |
| 239-243 | Preparation of Gelatin Nanocapsules and Their Pharmaceutical Characterization | Hans-Jürgen Krause and Peter Rohdewald |
| 243-245 | Effect of Salicylate on the Uptake of Cefmetazole into Brain of Mice | Hiroshi Yoshikawa, Kanji Takada, Yu-ichiro Satoh, Norio Naruse and Shozo Muranishi |
| 246-248 | Use of Lymphoblastoid Namalva Cell Cultures in a Toxicity Test. Application to the Monitoring of Detoxification Procedures for Fluorocarbons to be used as Intravascular Oxygen-Carriers | Maurice Le Blanc, Jean G. Riess, Daniel Poggi and R. Follana |
| 249-250 | Potentiation of Enteral Absorption of Human Interferon Alpha and Selective Transfer into Lymphatics in Rats | Hiroshi Yoshikawa, Kanji Takada, Yu-ichiro Satoh, Norio Naruse and Shozo Muranishi |
| 251-252 | Natural Occurrence of 11-O-Acetylambelline and 11-O-Acetyl-l ,2-β-epoxyambelline in Crinum latifolium: Immuno-regulant Alkaloids | Shibnath Ghosal, Potharaju H. Rao and Kulwant S. Saini |
| 253-261 | Leukotriene Biosynthesis Inhibitors | John R. Cashman |
| 262-266 | Program for Evaluating Drug Dissolution Kinetics in Preformulation | Martin Nicklasson and Anna-Britta Magnusson |
| 266-271 | Synthesis and Pharmacological Characterization of Fluorescent Opioid Receptor Probes | Vera M. Kolb, Ahmet Department of Pharmaceutical Pharmacology Koman and Anders Neil |
| 271-278 | Lymphatic Transport of Liposome-Encapsulated Drugs Following Intraperitoneal Administration – Effect of Lipid Composition | Koichiro Hirano, C. Anthony Hunt, Anne Strubbe and Roderick D. MacGregor |
| 279-284 | Effect of Age on the Disposition and Tissue Clearances of Fluorinated Pyrimidines in Rats | J. Lai-Sim Au |
| 284-293 | In Vitro Drug Absorption Models. I. Brush Border Membrane Vesicles, Isolated Mucosal Cells and Everted Intestinal Rings: Characterization and Salicylate Accumulation | Iwona Osiecka, Patty A. Porter, Ronald T. Borchardt, Joseph A. Fix and Colin R. Gardner |
| 293-298 | In Vitro Drug Absorption Models. II. Salicylate, Cefoxitin, α-Methyldopa and Theophylline Uptake in Cells and Rings: Correlation with In Vivo Bioavailability | Patty A. Porter, Iwona Osiecka, Ronald T. Borchardt, Joseph A. Fix and Linda Frost, et al. |
| 298-301 | Role of Peripheral Adrenergic Responsiveness in the Development of DOCA/NaCl Hypertension in Rats | Eme L Iloeje, Michael J. Katovich, Edward E. Soltis and F. Peter Field |
| 302-306 | Mechanical Activation of Pharmaceutical Systems | Reinhard Hüttenrauch, Sabine Fricke and Petra Zielke |
| 307-309 | Possible Mechanism Regulating Barrier Function of Rat Intestinal Mucosa against Permeation of Cefmetazole, a Hydrophilic Drug | Toshiaki Nishihata, Hideo Takahata and Akira Kamada |
| 309-310 | Change of Phase-Solubility Behavior by Gamma-Cyclodextrin Derivatization | Bernd W. Müller and Ulrich Brauns |
| 311-313 | High-Performance Liquid Chromatographic Analysis of Tocainide in Human Plasma | Ludo Conings and Norbert Verbeke |
| 313-315 | Prostaglandin D2 Induced Potentiation of the Anticonvulsant Actions of Phenobarbitone and Phenytoin in Rats. Role of Serotonin | Salil K. Bhattacharya and Surendra S. Parmar |
| 315-318 | Central Serotonergic Modulation of Carrageenin-induced Pedal Inflammation in Rats | Salil K. Bhattacharya and Neeta Das |
| 319-320 | Announcements |
| 323-324 | Author's Index: Pharmaceutical Research 1985 |
| 325-326 | Subject Index: Pharmaceutical Research 1985 |
| 65-74 | Fundamentals of Powder Compression. II. The Compression of Binary Powder Mixtures | Hans Leuenberger and Bhagwan Dass Rohera |
| 75-80 | Treatment of Filariasis—Diethylcarbamazine and Its Congeners | Satyavan Sharma |
| 81-87 | Characterization of an In Vitro Blood–Brain Barrier Model System for Studying Drug Transport and Metabolism | Kenneth L. Audus and Ronald T. Borchardt |
| 88-92 | An In Vitro Method of Evaluating Tolnaftate Release from Topical Powder | Tacey X. Viegas, Arthur H. Kibbe, Ahmed H. Hikal, Robert W. Cleary and Alan B. Jones |
| 93-101 | The Hypolipidemic Activity of a Series of 2,3-Dihydrophthalazine-l,4-dione Derivatives in Rodents | A. R. K. Murthy, I. H. Hall, J. M. Chapman, K. A. Rhyne and S. D. Wyrick |
| 102-107 | Pharmacodynamics of Basic Triamterene Derivatives | Helmut Priewer, Hildegard Spahn and Ernst Mutschler |
| 108-111 | Bioavailability of Propranolol After Oral, Sublingual, and Intranasal Administration | Guus S. M. J. E. Duchateau, Jan Zuidema and Frans W. H. M. Merkus |
| 112-115 | A Radioimmunoassay Procedure for the Determination of the Antiviral Nucleoside DHPG (9-[(l,3-Dihydroxy-2-propoxy)-methyl]guanine) in Plasma or Serum | Clinton Nerenberg, Sherrie McClung, John Martin, Marian Fass and JoAnn Fargue, et al. |
| 116-117 | Development of Interferon Suppositories. I. Enhanced Rectal Absorption of Human Fibroblast Interferon by Fusogenic Lipid via Lymphotropic Delivery in Rats | Hiroshi Yoshikawa, Kanji Takada, Yu-ichiro Satoh, Norio Naruse and Shozo Muranishi |
| 118-121 | Stabilization of Sulfamerazine Suspensions by Xanthan Gum | Joel L. Zatz and Christine Yarus |
| 123-131 | Comparison of Canine and Human Gastrointestinal Physiology | Jennifer B. Dressman |
| 132-141 | Characterization of the Urinary Metabolites of Primaquine in Rats | John K. Baker, James D. McChesney and Lucia F. Jorge |
| 142-149 | Determination of β-Endorphin and Fragments Thereof in Human Plasma Using High-Performance Liquid Chromatography and a Multiple Radioimmunoassay System | Klaus Wiedemann and Hansjörg Teschemacher |
| 150-155 | Saturable Processes Affecting Renal Clearance of Cefixime in Dogs | Alfred P. Tonelli, Meir Bialer, Zee M. Look, Steven Carson and Avraham Yacobi |
| 156-161 | Correlation Between In Vivo Antipyrine Metabolite Formation and Theophylline Metabolism in Rats | Michael W. E. Teunissen, Irinka O. N. Brorens, H. Joke De Langen, Anne M. Geerlings and Douwe D. Breimer |
| 162-166 | Role of Putative Neurotransmitters in Bradykinin-Induced Catalepsy in the Rat | Salil K. Bhattacharya, Patchala J. R. Mohan Rao, Stanley J. Brumleve and Surendra S. Parmar |
| 167-169 | The Effect of Amiodarone on Theophylline Pharmacokinetics in the Rat | Ghassem E. Larijani, Mario L. Rocci, Parviz Mojaverian, Consuelo L. Saccar and Cindy Hoholick, et al. |
| 170-172 | Fungal Metabolism of 4-Methylprimaquine | Alice M. Clark, James D. McChesney and Charles D. Hufford |
| 173-177 | Pharmacokinetics and Reversible Biotransformation of Sulfinpyrazone and Its Metabolites in Rabbits. I. Single-Dose Study | Wolfgang A. Ritschel |
| 178-183 | Pharmacokinetics and Reversible Biotransformation of Sulfinpyrazone and Its Metabolites in Rabbits. II. Multiple-Dose Study | Be-Sheng Kuo and Wolfgang A. Ritschel |
| 184 | Announcement |
| 185 | Editorial |
| 186 | AAPS and pharmaceutical research | Leslie Z. Benet |
| 187-194 | The interactions of water with cellulose- and starch-derived pharmaceutical excipients | George Zografi and Mark J. Kontny |
| 195-207 | The applications of synthetic oligonucleotides to molecular biology | Ronald W. Ellis |
| 208-213 | The effect of density on the gastric emptying of single- and multiple-unit dosage forms | Stanley S. Davis, Anita F. Stockwell, Margaret J. Taylor, John G. Hardy and David R. Whalley, et al. |
| 214-217 | Microviscosity and drug release from topical gel formulations | Khalil I. Al-Khamis, Stanley S. Davis and Jonathan Hadgraft |
| 218-224 | Conformation and electrostatic potential surfaces of opiates: Relationship to µ- and λ-site binding | Terry P. Lybrand, Peter A. Kollman, Victor C. Yu and Wolfgang Sadée |
| 225-229 | Systemic delivery of timolol after dermal application: Transdermal flux and skin irritation potential in the rat and dog | Robyn Cargill, Karen Engle, Gerald Rork and Larry J. Caldwell |
| 230-234 | Capsules with prolonged action. II. Capsule filling by a gelation process | Peter C. Schmidt and B. Stockebrand |
| 235-239 | Capsules with prolonged action. III. Release of active ingredients from cast films | Peter C. Schmidt and B. Stockebrand |
| 240-243 | Effect of lycoriside, an acylglucosyloxy alkaloid, on mast cells | Shibnath Ghosal, Amirthalingam Shanthy, Mita Mukhopadhyay, Mihir K. Sarkar and Prasun K. Das |
| 244-248 | In Vivo performance of ophthalmic preparations of betamethasone and phenylephrine hydrochloride in the rabbit eye: Effect of polyvinyl alcohol | Mahfouz A. Kassem, Mohamed A. Attia, Fawzia S. Habib and Abdel-Razak A. Mohamed |
| 249-251 | Association news and announcements |
| 253-262 | The Bioavailability of Dermatological and Other Topically Administered Drugs | Richard H. Guy, Anna H. Guy, Howard I. Maibach and Vinod P. Shah |
| 263-270 | A Critical Analysis of the Experimental Evaluation of Nociceptive Reactions in Animals | Krishnaswami Ramabadran and Mylarrao Bansinath |
| 271-277 | New Class of 5-Lipoxygenase Inhibitors: Correlation Between Inhibition of LTB4 Production and Chemiluminescence of Human Polymorphonuclear Granulocytes | Dieter Steinhilber, Karlheinz Schmidt, Kurt Eger and Hermann J. Roth |
| 278-285 | Improved Delivery Through Biological Membranes. XXIV. Synthesis, in Vitro Studies, and in Vivo Characterization of Brain-Specific and Sustained Progestin Delivery Systems | Marcus Eli Brewster, Kerry S. Estes and Nicholas Bodor |
| 286-289 | The Synthesis of Homophthalimide and Related Derivatives and Their Hypolipidemic Activity in Rodents | Akula R. K. Murthy, James M. Chapman, Steven D. Wyrick and Iris H. Hall |
| 290-293 | Selective Toxicity of the Antimalarial Primaquine—Evidence for Both Uncoupling and Inhibitory Effects of a Metabolite on the Energetics of Mitochondria and Its ATP Synthase Complex | John K. Baker, Joanne M. Hullihen and Peter L. Pedersen |
| 294-297 | The Influence of Urea on Percutaneous Absorption | Janet Beastall, Richard H. Guy, Jonathan Hadgraft and Ian Wilding |
| 298-301 | Thermal Decomposition of Thonzonium Bromide | Lester Chafetz, R. Clive Greenough and John Frank |
| 302-306 | In Vitro Cytotoxic Effects of Dibromodulcitol in 9L Rat Brain Tumor Cells | Stefan-M. Pulst, Victor A. Levin and Dennis F. Deen |
| 307-308 | Immunostimulatory Activity of Mangiferin, A Naturally Occurring Xanthone-C-Glucoside | U. Chattopadhyay, L. Chaudhuri and S. Ghosal |
| 309-310 | Association News and Announcements |
| 1-2 | EDITORIAL |
| 3-4 | Targeted Drug Delivery-Some Pharmacokinetic Considerations | Gerhard Levy |
| 5-15 | Fast Atom Bombardment Mass Spectrometry and Its Application to the Analysis of Some Peptides and Proteins | Mark E. Hemling |
| 16-20 | N-(2-Cyanoethyl)tranylcypromine, a Potential Prodrug of Tranylcypromine: Its Disposition and Interaction with Catecholamine Neurotransmitters in Brain | Adil J. Nazarali, Glen B. Baker, Ronald T. Coutts and T. F. James Wong |
| 21-27 | Synthesis and Hypolipidemic Activity of 3-Imino-l-oxoisoindolines in Rodents | Akula R. K. Murthy, Oi T. Wong, David J. Reynolds and Iris H. Hall |
| 28-32 | A Reversed-Phase High-Performance Liquid Chromatography Assay Procedure for Progabide and Its Related Metabolic Derivatives | Nidal F. Farraj, Stanley S. Davis, Graham D. Parr and Howard N. E. Stevens |
| 33-37 | Dose-Dependent Pharmacokinetics of a New Oral Cephalosporin, Cefixime, in the Dog | Meir Bialer, Vijay K. Batra, John A. Morrison, B. Michael Silber and Zee M. Look, et al. |
| 38-41 | High-Performance Liquid Chromatographic Assay for Thyrotropin Releasing Hormone and Benzyl Alcohol in Injectable Formulation | Gowdahalli N. Subba Rao, Jerry W. Sutherland and Gopi N. Menon |
| 42-45 | Stability of Lidocaine in Aqueous Solution: Effect of Temperature, pH, Buffer, and Metal Ions on Amide Hydrolysis | Michael F. Powell |
| 46-49 | Improved Radioreceptor Assay of Opiate Narcotics in Human Serum: Application to Fentanyl and Morphine Metabolism | Viktorya Levi, James C. Scott, Paul F. White and Wolfgang Sadée |
| 50-53 | Subcellular Distribution of Basic Drugs Accumulated in the Isolated Perfused Lung | Hisahiro Yoshida, Katsuhiko Okumura and Ryohei Hori |
| 54-58 | Automated Stability-Indicating High-Performance Liquid Chromatographic Assay for Ethinyl Estradiol and (Levo)norgestrel Tablets | Van D. Reif, W. Mark Eickhoff, John K. Jackman and Nicholas J. DeAngelis |
| 59-61 | Application of Moment Analysis to Nonlinear Drug Disposition Described by the Michaelis–Menten Equation | Andrew T. Chow and William J. Jusko |
| 62-65 | Effects of Plasma Proteins on Degradation Properties of Poly(L-lactide) Microcapsules | Kimiko Makino, Hiroyuki Ohshima and Tamotsu Kondo |
| 66-69 | Dissociation of the Natriuretic and Antikaliuretic Properties of Triamterene Derivatives by Dose–Response Experiments | Helmut Priewer, Erwin Wolf, Helga Kraft, Heinrich Knauf and Ernst Mutschler |
| 70-74 | Drug Release from Tablets Containing Cellulose Acetate Phthalate As an Additive or Enteric-Coating Material | Shan-Yang Lin and Y. Kawashima |
| 75-77 | Report of the Workshop on Controlled-Release Dosage Forms: Issues and Controversies | Jerome P. Skelly, William H. Barr, Leslie Z. Benet, James T. Doluisio and Arthur H. Goldberg, et al. |
| 78 | The Effect of Density on the Gastric Emptying and Intestinal Transit of Solid Dosage Forms: Comments on the Article by Davis et al. | Lydia C. Kaus |
| 79-81 | Association News and Announcements |
| 83-85 | Managing Potential Conflicts of Interest in University-Industrial Partnerships | Michael A. Schwartz |
| 86-91 | Kinetic-Effect Models and Their Applications | Joachim Grevel |
| 92-97 | Use of Vaccinia Virus to Express Biopharmaceutical Products | Dennis E. Hruby and Gary Thomas |
| 98-103 | Kinetics and Mechanism of Captopril Oxidation in Aqueous Solution Under Controlled Oxygen Partial Pressure | Tak-Yee Lee and Robert E. Notari |
| 104-112 | Water Vapor Sorption of Water-Soluble Substances: Studies of Crystalline Solids Below Their Critical Relative Humidities | Mark J. Kontny, George P. Grandolfi and George Zografi |
| 113-119 | Effect of Pyrimidine Nucleosides on Body Temperatures of Man and Rabbit in Relation to Pharmacokinetic Data | Godefridus J. Peters, Cees J. van Groeningen, Emile Laurensse, Ineke Kraal and Albert Leyva, et al. |
| 120-125 | Selection of a Derivative of the Antiviral Agent 9-[(1,3-Dihydroxy-2-propoxy)-methyl]Guanine (DHPG) with Improved Oral Absorption | Eric J. Benjamin, Bruce A. Firestone, Robert Bergstrom, Marian Fass and Ian Massey, et al. |
| 126-129 | Identification of Prescription Drugs in Adulterated Chinese Herbal Medications | Thomas Cairns, Emil G. Siegmund and Bobby R. Rader |
| 130-132 | Prostaglandin Derivative PGBX Improves Neurologic Recovery After Ischemic Spinal Injury | Thomas P. Jacobs, John M. Hallenbeck, Thomas M. Devlin and Giora Z. Feuerstein |
| 133-136 | A High-Performance Liquid Chromatographic Microassay Employing a Liquid–Solid Extraction Technique for Etintidine in Plasma | Shiew-Mei Huang, Elaine Rubin and Thomas B. Marriott |
| 137-141 | The Solid-State Decarboxylation of the Diammonium Salt of Moxalactam | Stephen R. Byrn, Phillipe Perrier, Chung-Tang Lin, Herberto Martinez and Ralph R. Pfeiffer |
| 142-146 | Binding of Basic Drugs to Rat Lung Mitochondria | Ryohei Hori, Katsuhiko Okumura and Hisahiro Yoshida |
| 147-149 | A Naloxone–Steroid Hybrid Azine with Selective and Long-Acting Opioid Antagonism at Delta Receptors In Vitro | Ahmet Koman, Vera M. Kolb and Lars Terenius |
| 150-153 | Influence of Tablet Dissolution on Furosemide Bioavailability: A Bioequivalence Study | Patrick J. McNamara, Thomas S. Foster, George A. Digenis, Rajani B. Patel and William A. Craig, et al. |
| 154-157 | A Novel Method for the Synthesis of Kyotorphin, Tyr-Arg, and 3H-Tyr-Arg, Catalyzed by Tyrosyl-tRNA Synthetase from Bacillus stearothermophilus | Senji Kitabatake, Ryoichi Tsurutani, Hiroshi Nakajima, Kosuke Tomita and Yoshihiro Yoshihara, et al. |
| 158-161 | Phenolic Cyclization of Epinephrine, Metaproterenol, Metaraminol, Phenylephrine, and Terbutaline with Formaldehyde | Lester Chafetz and Ramazan Turdiu |
| 162-165 | A New Parenteral Emulsion for the Administration of Taxol | B. D. Tarr, T. G. Sambandan and S. H. Yalkowsky |
| 166-170 | Synthesis and Pharmacological Activity of N- Alkyl-1,2-Diphenylethanolamines | Humeida A. El-Obeid, Abdul Azim E. Madani, Khalid A. Al-Rashood, Kamal E. H. El Tahir and Abdul Karim Tilmisani, et al. |
| 171-172 | In Vitro and In Vivo Interactions of Furosemide and Sucralfate | Ahmed H. Hikal, Larry A. Walker and Thirucote Ramachandran |
| 173-175 | Association News and Announcements |
| 177-180 | A Critical Appraisal of Drug Stability Testing Methods | Robert B. Taylor and Amin S. H. Shivji |
| 181-188 | Immunoconjugates: Applications in Targeted Drug Delivery for Cancer Therapy | Bhanu P. Ram and Praveen Tyle |
| 189-194 | Radioreceptor Assay for Insulin Formulations | Lars Sjödin and Eila Viitanen |
| 195-199 | An Equation for the Systemic Availability of Drugs Undergoing Simultaneous Enterohepatic Cycling, First-Pass Metabolism, and Intestinal Elimination | Theresa A. Shepard and Richard H. Reuning |
| 200-206 | Efficacy of 5-Vinyl-l-β-D-arabinofuranosyluracil (VaraU) Against Herpes Simplex Virus Type 2 Strains in Cell Cultures and Against Experimental Herpes Encephalitis in Mice: Comparison with Acyclovir and Foscarnet | Jürgen Reefschläger, Peter Wutzler, Klaus-Dieter Thiel and Gottfried Herrmann |
| 207-213 | Synthesis and Properties of Haptens for the Development of Radioimmunoassays for Thioridazine, Mesoridazine, and Sulforidazine | Bhaswat S. Chakraborty, Manik S. Sardessai, Theodore J. Jaworski, Kamal K. Midha and Edward M. Hawes |
| 214-219 | Kinetics and Mechanism of Zinc Ion-Mediated Degradation of Cephalosporins in Tromethamine Solution | Hisao Tomida, Kazuya Kohashi, Yasuto Tsuruta, Setsuo Kiryu and Michael A. Schwartz |
| 220-230 | Cosolvency and Cosolvent Polarity | Joseph T. Rubino and Samuel H. Yalkowsky |
| 231-236 | Cosolvency and Deviations from Log-Linear Solubilization | Joseph T. Rubino and Samuel H. Yalkowsky |
| 237-239 | Identification of Phenolic Antioxidants in Elastomers for Pharmaceutical and Medical Use | Charles B. Airaudo, André Gayte-Sorbier, Roland Creusevau and Régine Dumont |
| 240-243 | Kinetics of Drug Action in Disease States. XXII. Effects of Contraceptive Steroids on the Pharmacodynamics of Ethanol in Rats | Sompon Wanwimolruk and Gerhard Levy |
| 244-247 | Adsorption of Inorganic and Organic Ions to Polycarbophil as a Means of Sustained-Release Dosage Formulation | Norman A. See, James Russell, Kenneth A. Connors and Paul Bass |
| 248-250 | Effects of Hypothermia on Drug Absorption | Salomon Stavchansky and I-lan Tung |
| 251-254 | Effect of Amiodarone and Desethylamiodarone on the Pharmacokinetics of Antipyrine in the Rat | Craig K. Svensson, Li-Ling Liu and Philip W. Knowlton |
| 255-257 | Preformulation Salt Selection. Physical Property Comparisons of the Tris(hydroxymethyl)aminomethane (THAM) Salts of Four Analgesic/Antiinflammatory Agents with the Sodium Salts and the Free Acids | Leo Gu and Robert G. Strickley |
| 258-260 | Analysis of the Antimalarial Sesquiterpene Artemisinin in Artemisia annua by High-Performance Liquid Chromatography (HPLC) with Postcolumn Derivatization and Ultraviolet Detection | Hala N. ElSohly, E. M. Croom and M. A. ElSohly |
| 261-262 | A Reversed-Phase High-Performance Liquid Chromatographic (HPLC) Assay for the Determination of Biotin in Multivitamin–Multimineral Preparations | Sharon L. Crivelli, Peter F. Quirk, Daniel J. Steible and S. P. Assenza |
| 263-264 | Obituary: Dr. Takeru Higuchi (1918-1987) |
| 265-267 | FDA and AAPS Report of the Workshop on Principles and Practices of In Vitro Percutaneous Penetration Studies: Relevance to Bioavailability and Bioequivalence | Jerome P. Skelly, Vinod P. Shah, Howard I. Maibach, Richard H. Guy and Ronald C. Wester, et al. |
| 268-270 | Association News and Announcements |
| 271-277 | The Lipoidal Permeability Barriers of the Skin and Alimentary Tract | William Curatolo |
| 278-284 | Protein Degradation: The Role of Mixed-Function Oxidases | Valeric Daggett |
| 285-292 | Enantiomeric Resolution of Drug Compounds by Liquid Chromatography | H.Thomas Karnes and Mohamadi A. Sarkar |
| 293-300 | Disposition and Tumor Localization of Mitomycin C–Dextran Conjugates in Mice | Yoshinobu Takakura, Akira Takagi, Mitsuru Hashida and Hitoshi Sezaki |
| 301-304 | Validation of Fiber-Optic Doppler Anemometry (FODA) for Characterizing the Droplet Size of Emulsions | Barbara J. Floy, Joe L. White and Stanley L. Hem |
| 305-310 | Coupling of Naltrexone to Biodegradable Poly(α-Amino Acids) | Naoki Negishi, David B. Bennett, Chong-Su Cho, SeoYoung Jeong and Wolfgang A. R. Heeswijk, et al. |
| 311-316 | Computer-Aided Dosage Form Design. I. Methods for Defining a Long-Acting First-Order Delivery System of Maximum Formulating Flexibility | Tak-Yee Lee and Robert E. Notari |
| 317-320 | N-Mannich-Base Prodrugs of 5-Iodo-2′-deoxycytidine as Topical Delivery Enhancers | Suzanne A. M. Koch and Kenneth B. Sloan |
| 321-326 | Synthesis and Biological Activity of Isodithiobiurets, Dithiobiurets, and Dithiazoles | Surendra N. Pandeya, Ashok Kumar, Bhav N. Singh and Dina N. Mishra |
| 327-331 | High-Performance Liquid Chromatographic (HPLC) Assay Using Fluorescence Detection for the Simultaneous Determination of Gallopamil and Norgallopamil in Human Plasma | Angus M. McLean, Elizabeth Babcock-Atkinson, Kathleen Rein, Donald A. Ruggirello and Mario A. Gonzalez, et al. |
| 332-336 | Pharmacokinetics of Gold Sodium Thiomalate in Rabbits | Srikumaran Melethil and Darryle Schoepp |
| 337-341 | Validation of a Flow-Through Diffusion Cell for Use in Transdermal Research | William J. Addicks, Gordon L. Flynn and Norman Weiner |
| 342-347 | Temperature and pH Dependence of Fluocinolone Acetonide Degradation in a Topical Cream Formulation | Richard A. Kenley, MaryannOtt Lee, Lakshmi Sukumar and Michael F. Powell |
| 348-352 | Effects of Formulation and Food on the Absorption of Hydrochlorothiazide and Triamterene or Amiloride from Combination Diuretic Products | Roger L. Williams, Joyce Mordenti, Robert A. Upton, Emil T. Lin and Winnie L. Gee, et al. |
| 353-354 | Microbial Transformation of Tamoxifen | Saleh El-Sharkawy and Yusuf J. Abul-Hajj |
| 355-357 | Binding of Piroxicam to Human Serum Albumin: Effect of Piroxicam on Warfarin and Diazepam Binding | Kenji Matsuyama, Asok C. Sen and John H. Perrin |
| 358 | EDITORIAL |
| 359 | Association News and Announcements |
| 361-363 | Emerging Trends in Biotechnology: A Perspective from the Pharmaceutical Industry | William Szkrybalo |
| 364-374 | Renin Inhibitors | William J. Greenlee |
| 375-378 | Recombinant Tissue Plasminogen Activator: A Brief Review | Elliott B. Grossbard |
| 379-384 | Development of Acute Tolerance to Bumetanide: Bolus Injection Studies | Jack A. Cook and David E. Smith |
| 385-391 | Computer-Aided Dosage Form Design. II. Methods for Defining a Zero-Order Sustained-Release Delivery System of Maximum Formulating Flexibility | Tak-Yee Lee and Robert E. Notari |
| 392-397 | Diketopiperazine Formation, Hydrolysis, and Epimerization of the New Dipeptide Angiotensin-Converting Enzyme Inhibitor RS-10085 | Leo Gu and Robert G. Strickley |
| 398-401 | Estimation of Surface Polarity of Silicas by Absorption Spectroscopy of Glycerin Suspensions of Adsorbed 6-Nitrobenzoindolinopyran | Michael J. Jozwiakowski and Kenneth A. Connors |
| 402-405 | Multiple-Dose Pharmacokinetics of Clozapine in Patients | Miles G. Choc, Robert G. Lehr, Frances Hsuan, Gilbert Honigfeld and Harold T. Smith, et al. |
| 406-408 | Prostaglandin D2 Inhibits Pentylenetetrazole-Induced Convulsions in Rats by a Serotonin-Mediated Mechanism | Salil K. Bhattacharya and Surendra S. Parmar |
| 409-411 | Bioavailability and Pharmacokinetics of a New Sustained-Release Potassium Chloride Tablet | Charles J. Betlach, John D. Arnold, R. Wayne Frost, Philip T. Leese and Mario A. Gonzalez |
| 412-415 | Quantitative Analysis of Hydroxyurea and Urea by Proton Nuclear Magnetic Resonance (NMR) Spectroscopy | Karen B. Main, Thomas Medwick, Leonard C. Bailey and John H. Shinkai |
| 416-419 | Analysis of in Vitro Dissolution of Whole vs. Half Controlled-Release Theophylline Tablets | Vinod P. Shah, Lawrence A. Yamamoto, Donald Schuirman, Jerome Elkins and Jerome P. Skelly |
| 420-424 | Dose-Proportional Absorption of Etretinate After Doses of 25, 50, 75, and 100 mg | Robert J. Wills, Lolita C. Rodriguez, Amy H. Lin, Clara Puccini and Wayne A. Colburn |
| 425-428 | Inhibition of Intestinal Pyrimidine Nucleoside Phosphorylases | M. Guill Wientjes and J. Lai-Sim Au |
| 429-432 | Polymorphism of l,2-Dihydro-6-neopentyl-2-oxonicotinic Acid: Characterization, Interconversion, and Quantitation | Robert S. Chao and Kenneth C. Vail |
| 433-435 | Pharmacokinetics of Pentoxifylline During Concomitant Theophylline Administration to Rats | Mario L. Rocci, David R. Luke and Consuelo L. Saccar |
| 436-437 | The Effect of Vehicle Additives on the Transdermal Delivery of Nitroglycerin | Thorsteinn Loftsson, Nancy Gildersleeve and Nicholas Bodor |
| 438 | Electrode Material in Iontophoresis | Lars Erik Linblad and Lena Ekenvall |
| 439-442 | Bio-organic and Natural Products Chemistry Molecular Biology Workshop | Laurence H. Hurley, John Kozarich and Michael Rogers |
| 443 | EDITORIAL |
| 444 | Association News and Announcements |
| 445-449 | The Influence of Drugs on Nasal Ciliary Movement | Walter A. J. J. Hermens and Frans W. H. M. Merkus |
| 450-456 | Electron-Transfer and Charge-Transfer Clastic Binding Hypotheses for Drug–Receptor Interactions | Vera M. Kolb |
| 457-464 | Mechanisms of Mucoadhesion of Poly(acrylic Acid) Hydrogels | Haesun Park and Joseph R. Robinson |
| 465-471 | The Preparation and Evaluation of Drug-Containing Poly(dl-lactide) Microspheres Formed by the Solvent Evaporation Method | Roland Bodmeier and James W. McGinity |
| 472-479 | Hypolipidemic Activity of o-(N-Phthalimido)acetophenone in Sprague Dawley Rats | Iris H. Hall, David J. Reynolds, Oi T. Wong, C. Brent Oswald and Akula R. K. Murthy |
| 480-485 | Investigation of the Gastrointestinal Transit and In Vivo Drug Release of Isosorbide-5-Nitrate Pellets | Wilfried Fischer, Anna Boertz, Stanley S. Davis, Raj Khosla and Willi Cawello, et al. |
| 486-489 | Correlation of Ibuprofen Bioavailability with Gastrointestinal Transit by Scintigraphic Monitoring of 171Er-Labeled Sustained-Release Tablets | Alan F. Parr, Robert M. Beihn, Robert M. Franz, Gregory J. Szpunar and Michael Jay |
| 490-494 | Tissue Tolerance of Intramuscular Injectables and Plasma Enzyme Activities in Rats | Christian Surber and Heinz Sucker |
| 495-498 | In Vivo Efficacy of Antifungal Oxoaporphine Alkaloids in Experimental Disseminated Candidiasis | Alice M. Clark, E. Sue Watson, M. Khalid Ashfaq and Charles D. Hufford |
| 499-503 | Between-Lot and Within-Lot Comparisons of Bioavailability of Macrocrystalline Nitrofurantoin Capsules | William D. Mason, John D. Conklin and Francis J. Hailey |
| 504-508 | Measurement of the Particle Size of Tablet Excipients with the Aid of Video Recording | Kanneganti P. P. Prasad and Lucy S. C. Wan |
| 509-514 | Effect of Helenalin and Bis(helenalinyl)malonate on Nucleic Acid and Protein Synthesis in Human KB Carcinoma Cells | Iris H. Hall, Anne A. Grippo, Kuo-Hsiung Lee, Stephen G. Chaney and David J. Holbrook |
| 515-518 | Effect of Hydralazine on the Elimination of Antipyrine in the Rat | Craig K. Svensson, Philip W. Knowlton and Joseph A. Ware |
| 519-523 | Percutaneous Absorption and Elimination of the Penetration Enhancer Azone in Humans | Johann W. Wiechers, Ben F. H. Drenth, Jan H. G. Jonkman and Rokus A. de Zeeuw |
| 524-526 | Radiolabeling of Intact Dosage Forms by Neutron Activation: Effects on In Vitro Performance | Alan Parr and Michael Jay |
| 527-530 | Therapeutic Effect of Dexamethasone in T-2 Toxicosis | Esther Shohami, Burt Wisotsky, Oliver Kempski and Giora Feuerstein |
| 531-535 | Kinetics of Potassium Excretion Following Oral Supplements: Evidence of Induced Natriuresis | Ashok Rakhit, Srikumaran Melethil, John D. Arnold and William E. Wagner |
| 536 | Assessment of Variance in Bioavailability Studies: Comments on the Article by McNamara et al. | Carl M. Metzler |
| 537 | Association News and Announcements |
| 538-540 | Reviewers for Pharmaceutical Research (1987) |
| 541-543 | Author Index to Volume 4 (1987) |
| 544-548 | Subject Index to Volume 4 (1987) |
| 1-9 | Monoclonal Antibodies as Magic Bullets | Frances M. Brodsky |
| 10-15 | Liquid Chromatographic Analysis of Di(2-ethylhexyl) Phthalate: Application to Pharmacokinetic Studies in the Mongrel Dog | David B. Haughey, William F. Elmquist, David A. Breutzmann, D. Gary Hemphill and Edward G. Constantini |
| 16-20 | Release of Lonapalene from Two-Phase Emulsion-Type Ointment Systems | John T. H. Ong and Elizabeth Manoukian |
| 21-30 | Porous Biodegradable Microspheres for Controlled Drug Delivery. I. Assessment of Processing Conditions and Solvent Removal Techniques | Toyomi Sato, Motoko Kanke, Hans G. Schroeder and Patrick P. DeLuca |
| 31-35 | Structural Determination of Testosterone Esters in Oil Injectables by Thermospray Mass Spectrometry | Thomas Cairns, Emil G. Siegmund and Thomas S. Savage |
| 36-39 | Comparison of Output Particle Size Distributions from Pressurized Aerosols Formulated as Solutions or Suspensions | Richard N. Dalby and Peter R. Byron |
| 40-43 | Pharmacokinetics of Ibuprofen Enantiomers in Humans Following Oral Administration of Tablets with Different Absorption Rates | Fakhreddin Jamali, Nikhilesh N. Singh, Franco M. Pasutto, Anthony S. Russell and Ronald T. Coutts |
| 44-47 | Prodrugs for Improved Oral β-Estradiol Bioavailability | Munir A. Hussain, Bruce J. Aungst and Eli Shefter |
| 48-52 | The Effect of Food on the Absorption of Controlled-Release Theophylline in Mini-Swine | Gerald K. Shiu, Arlen O. Sager, Raja B. Velagapudi, Vadlamani K. Prasad and Jerome P. Skelly |
| 53-56 | Stereospecific High-Performance Liquid Chromatographic (HPLC) Assay of Fenoprofen Enantiomers in Plasma and Urine | Reza Mehvar and Fakhreddin Jamali |
| 57-60 | An Area Function Method for Estimating the Apparent Absorption Rate Constant | Haiyung Cheng, Alfred E. Staubus and Linyee Shum |
| 61-64 | Effect of Taurolithocholate on In Vivo Sulfation and Glucuronidation of Acetaminophen in Rats | Raymond E. Galinsky and Barbara Chalasinska |
| 65 | Editorial |
| 66 | Association News and Announcements |
| 129-139 | The Role of Tumor Necrosis Factor and Interleukin 1 in the Immunoinflammatory Response | James W. Larrick and Steven L. Kunkel |
| 140-150 | The Role of Protein and Lipid Domains in the Uptake of Solutes by Human Stratum Corneum | Prakash V. Raykar, Man-Cheong Fung and Bradley D. Anderson |
| 151-155 | Bambuterol: Uptake and Metabolism in Guinea Pig Isolated Lungs | Åke Ryrfeldt, Elisabeth Nilsson, Anders Tunek and Leif-Åke Svensson |
| 156-164 | Mean Residence Time Concepts for Pharmacokinetic Systems with Nonlinear Drug Elimination Described by the Michaelis–Menten Equation | Haiyung Cheng and William J. Jusko |
| 165-171 | Assessment and Validation of Animal Models to Evaluate Topical Effects of Substances on Gastrointestinal Mucosa | John W. Fara, Larry D. Anderson, Alfred G. T. Casper and Robert E. Myrback |
| 172-177 | High-Performance Liquid Chromatographic Assay of a Central Nervous System (CNS)-Directed Estradiol Chemical Delivery System and Its Application After Intravenous Administration to Rats | Gotelind Mullersman, Hartmut Derendorf, Marcus E. Brewster, Kerry S. Estes and Nicholas Bodor |
| 178-182 | Relation Between Individual and Ensemble Release Kinetics of Indomethacin from Microspheres | Simon Benita, Dany Babay, Amnon Hoffman and Max Donbrow |
| 183-186 | Phenobarbital Adsorption from Simulated Intestinal Fluid, U.S.P., and Simulated Gastric Fluid, U.S.P., by Two Activated Charcoals | Dale Eric Wurster, Gerald M. Burke, Mary J. Berg, Peter Veng-Pedersen and Dorothy D. Schottelius |
| 187-189 | Measurement of Underivatized Propranolol Enantiomers in Serum Using a Cellulose –Tris(3,5 -Dimethylphenylcarbamate) High-Performance Liquid Chromatographic (HPLC) Chiral Stationary Phase | Robert J. Straka, Richard L. Lalonde and Irving W. Wainer |
| 190-192 | Determination of a Novel Antiarrhythmic Agent ACC-9358 in Human Plasma by High-Performance Liquid Chromatography | Ramanuj Achari and David A. Thomas |
| 193-195 | The Estimation of Solubility in Binary Solvents: Application of the Reduced 3-Suffix Solubility Equation to Ethanol–Water Mixtures | N. Adeyinka Williams and Gordon L. Amidon |
| 196 | Calculations and Application of Mean Residence Times for Drugs Which Demonstrate One-Compartment Distribution and Michaelis-Menten Elimination | Jack A. Cook and Peter R. Gwilt |
| 197-198 | Association News and Announcements |
| 199-200 | Genes and the Pharmaceutical Sciences | Wolfgang Sadée |
| 201-208 | Quantitative Structure–Activity Study on Human Pharmacokinetic Parameters of Benzodiazepines Using the Graph Theoretical Approach | Rodney S. Markin, Wallace J. Murray and Harold Boxenbaum |
| 209-213 | Role of Phosphatidylserine in the Cellular and Subcellular Lung Distribution of Quinidine in Rats | Akio Nishiura, Teruo Murakami, Yutaka Higashi and Noboru Yata |
| 214-219 | Stability of Prostacyclin Analogues: An Unusual Lack of Reactivity in Acid-Catalyzed Alkene Hydration | Adina Magill, Counde O'Yang and Michael F. Powell |
| 220-225 | Capillary Gas Chromatography and Thermionic N-P-Specific Detection of 13-Bis(2-chloroethyl)-l-nitrosourea (BCNU) or l-(2-Chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU) in Stability and Pharmacokinetic Studies | Adnan El-Yazigi and Cazemiro R. Martin |
| 226-231 | The Stability and Solubility of Progabide and Its Related Metabolic Derivatives | Nidal F. Farraj, Stanley S. Davis, Graham D. Parr and Howard N. E. Stevens |
| 232-235 | A Biotin–Avidin-Based Enzyme Immunoassay for βh-Endorphin | Guenther Hochhaus and Wolfgang Sadée |
| 236-237 | Antimuscarinic Effects of (R)- and (S)-Oxyphencyclimine Hydrochloride | Lise Schjelderup, Michael R. Kozlowski, Albert Weissman and Arne J. Aasen |
| 238-241 | The Effect of Azone on Ocular Levobunolol Absorption: Calculating the Area Under the Curve and Its Standard Error Using Tissue Sampling Compartments | Diane D.-S. Tang-Liu and P. Joshua Burke |
| 242-244 | Antihypertensive Activity of 2[(2-Hydroxyphenyl) amino] -4(3H)-quinazolinone | Munir A. Hussain, Andrew T. Chiu, William A. Price, Pieter B. Timmermans and Eli Shefter |
| 245-246 | Comparing the Biological Activity of Humulin R and Novolin R Using an Intravenous Bioassay | Ghana R. Kowarski, Senshang Lin, Lora M. Michalek and A. Avinoam Kowarski |
| 247-248 | ABSPLOTS: A LOTUS 123 Spreadsheet for Calculating and Plotting Drug Absorption Rates | Robert C. Shumaker, Harold Boxenbaum and Gary A. Thompson |
| 249 | Interpretation of Drug Stability Testing | Lester Chafetz |
| 250 | Approaches to Drug Stability | Robert B. Taylor |
| 251 | Electrode Material in Iontophoresis | Praveen Tyle |
| 252 | Association News and Announcements |
| 253-260 | Free Radicals and Oxygen Toxicity | Douglas D. Buechter |
| 261-265 | The Protein Binding of Phenytoin, Propranolol, Diazepam, and AL01576 (an Aldose Reductase Inhibitor) in Human and Rat Diabetic Serum | Patrick J. McNamara, Robert A. Blouin and Romulus K. Brazzell |
| 266-271 | Epimerization Kinetics of Moxalactam in Frozen Solution | Naofumi Hashimoto, Teruhisa Ichihashi, Etsuko Yamamoto, Koichiro Hirano and Masayoshi Inoue, et al. |
| 272-282 | Dissolution of lonizable Drugs in Buffered and Unbuffered Solutions | Sadettin S. Ozturk, Bernhard O. Palsson and Jennifer B. Dressman |
| 283-287 | Development of a Radioreceptor Assay for the D2-Selective Dopamine Agonist N-0437 | Kees Ensing, Dick A. Bloemhof, Willy G. in't Hout, Jan van der Lende and Rokus A. de Zeeuw |
| 288-296 | Potential Improvement in the Shelf Life of Parenterals Using the Prodrug Approach: Bacampicillin and Talampicillin Hydrolysis Kinetics and Utilization Time | Ngoc-Anh T. Nguyen, Lobna M. Mortada and Robert E. Notari |
| 297-299 | Thiol Reduction of 3′-Azidothymidine to 3′-Aminothymidine: Kinetics and Biomedical Implications | Anthony L. Handlon and Norman J. Oppenheimer |
| 300-304 | Receptor-Mediated Magnetic Carriers: Basis for Targeting | James M. Gallo and Emad Eldin Hassan |
| 305-308 | Site Dependence of Absorption-Promoting Actions of Laureth-9, Na Salicylate, Na2EDTA, and Aprotinin on Rectal, Nasal, and Buccal Insulin Delivery | Bruce J. Aungst and Nancy J. Rogers |
| 309-312 | Enhanced Membrane Permeability to Phenol Red by Medium-Chain Glycerides: Studies on the Membrane Permeability and Microviscosity | Kazutaka Higaki, Muneyoshi Kato, Mitsuru Hashida and Hitoshi Sezaki |
| 313-315 | Mass Balance and Dose Accountability in Percutaneous Absorption Studies: Development of a Nonocclusive Application System | Daniel A. W. Bucks, Howard I. Maibach and Richard H. Guy |
| 316-318 | Stereoselective Binding of Disopyramide to Plasma Proteins | Luisa Valdivieso, Kathleen M. Giacomini, Wendel L. Nelson, Robert Pershe and Terrence F. Blaschke |
| 319-321 | Serum Protein Binding of AL01576, a New Aldose Reductase Inhibitor | Patrick J. McNamara, Robert A. Blouin and R. K. Brazzell |
| 322 | Reply to “Assessment of Variance in Bioavailability Studies: Comments on the Article by McNamara et al.” by Carl M. Metzler. | Jerome P. Skelly, Vinod P. Shah and Donald J. Schuirmann |
| 323-324 | Association News and Announcements |
| 325-334 | Approaches to Radiolabeling of Antibodies for Diagnosis and Therapy of Cancer | Alan R. Fritzberg, Ronald W. Berninger, Stephen W. Hadley and Dennis W. Wester |
| 335-340 | Disposition of Detirelix, A Potent Luteinizing Hormone-Releasing Hormone Antagonist, in Rats and Monkeys | Rebecca L. Chan, William Ho, Austin S. Webb, JoAnn LaFargue and Clinton A. Nerenberg |
| 341-346 | Enhancement of Colonic Drug Absorption by the Paracellular Permeation Route | Mikio Tomita, Masaharu Shiga, Masahiro Hayashi and Shoji Awazu |
| 347-351 | Metabolite Formation Pharmacokinetics: Rate and Extent of Metabolite Formation Determined by Deconvolution | Michael D. Karol and Scott Goodrich |
| 352-358 | Cellular Uptake of a Fluid-Phase Marker by Human Neutrophils from Solutions and Liposomes | Jeffrey F. Scieszka and Moo J. Cho |
| 359-364 | Structure–Activity Relationship Studies of Hemicholinium (HC-3) Congeners | Joseph G. Cannon, Teresa M.-L. Lee, Y.-a. Chang, Alfred M. Nyanda and Bula Bhattacharyya, et al. |
| 365-368 | Liquid Chromatographic Assay and Pharmacokinetics of Quazepam and Its Metabolites Following Sublingual Administration of Quazepam | Samir K. Gupta and Everett H. Ellinwood |
| 369-371 | Carrier-Mediated Transport of Baclofen Across Monolayers of Bovine Brain Endothelial Cells in Primary Culture | Joost B. M. M van Bree, Kenneth L. Audus and Ronald T. Borchardt |
| 372-376 | In Vitro Measurement of Gastrointestinal Tissue Permeability Using a New Diffusion Cell | George M. Grass and Stephanie A. Sweetana |
| 377-382 | Drug Transport from Thin Applications of Topical Dosage Forms: Development of Methodology | William J. Addicks, Gordon L. Flynn, Norman Weiner and Chia-Ming Chiang |
| 383-386 | Assay for Hydralazine as Its Stable p-Nitrobenzaldehyde Hydrazone | Hugh A. Semple, Yun K. Tam, Sarah Tin and Ronald T. Courts |
| 387-390 | Time-Dependent Absorption of Phenprobamate Following Multiple Dosing in Rats | Jim Xin-Sheng Sun, Koral Embil and Ching-San C. Lee |
| 391-395 | Thermodynamics in the Prediction of the Solubilities of Binary Mixtures of the Diastereoisomers and Enantiomers of Ephedrine | Walter F. Schmidt, William Porter and Jens. T. Carstensen |
| 396 | Association News and Announcements |
| 397-400 | Drug Discovery—Today and Tomorrow: The Role of Medicinal Chemistry | Kurt R. Freter |
| 401-407 | Pharmacodynamics of Zoxazolamine and Chlorzoxazone in Rats | Masato Yasuhara and Gerhard Levy |
| 408-412 | Searching for the Endogenous Benzodiazepine Using the Graph Theoretical Approach | Rodney S. Markin and Wallace J. Murray |
| 413-420 | The Effects of Phthalimide and Saccharin Derivatives on Low-Density Lipoprotein (LDL) and High-Density Lipoprotein (HDL) Receptor Activity and Related Enzyme Activities | Iris H. Hall, Oi T. Wong and Steven D. Wyrick |
| 421-425 | Hygroscopicity of Cefazolin Sodium: Application to Evaluate the Crystallinity of Freeze-Dried Products | Takashi Osawa, Madhav S. Kamat and Patrick P. DeLuca |
| 426-429 | Estimation of the Degree of Crystallinity of Cefazolin Sodium by X-Ray and Infrared Methods | Madhav S. Kamat, Takashi Osawa, Robert J. DeAngelis, Yasuto Koyama and Patrick P. DeLuca |
| 430-433 | Receptor Binding Studies of the Flavone, REC 15/2053, and Other Bladder Spasmolytics | GianAlfredo Abbiati, Roberto Ceserani, Dante Nardi, Claudio Pietra and Rodolfo Testa |
| 434-436 | Evidence for the Involvement of a Nitrenium Ion in the Covalent Binding of Nitrofurazone to DNA | Anthony J. Streeter and Betty-ann Hoener |
| 437-439 | Dextromethorphan Pretreatment Induces Antipyrine Clearance in the Rat | Craig K. Svensson and Joseph A. Ware |
| 440-442 | Protein Binding of Cocaine in Human Serum | David J. Edwards and Susan K. Bowles |
| 443-446 | A New System for In Vitro Studies of Iontophoresis | Peretz Glikfeld, Christopher Cullander, Robert S. Hinz and Richard H. Guy |
| 447-452 | Teratogenic and Behavioral Anomalies Induced by Acute Exposure of Mice to Ethanol and Their Possible Relation to Fetal Brain DNA Synthesis | Arthur A. Ciociola and Ronald F. Gautieri |
| 453-456 | Absorption Enhancement of Rectally Infused Cefoxitin Sodium by Medium-Chain Fatty Acids in Conscious Rats: Concentration–Effect Relationship | Ewoud J. van Hoogdalem, Martin A. Hardens, Albertus G. de Boer and Douwe D. Breimer |
| 457-462 | Percutaneous Absorption of Nicardipine and Ketorolac in Rhesus Monkeys | Diana Yu, Lynda M. Sanders, George W. R. Davidson III, Martha J. Marvin and Teck Ling |
| 463 | Association News and Announcements |
| 465-471 | Renal Transport of Drugs: An Overview of Methodology with Application to Cimetidine | Kathleen M. Giacomini, Poe-Hirr Hsyu and Lee G. Gisclon |
| 472-476 | Recombinant Human Interferon Alpha-2a: Delivery to Lymphoid Tissue by Selected Modes of Application | Andreas Supersaxo, Wayne Hein, Harald Gallati and Hans Steffen |
| 477-481 | Percutaneous and Systemic Disposition of Hexamethylene Lauramide and Its Penetration Enhancement Effect on Hydrocortisone in a Rat Sandwich Skin-Flap Model | Diane D-S. Tang-Liu, John Neff, Heraldo Zolezio and Rhonda Sandri |
| 482-487 | Determination of the pH-Dependent Phase Distribution of Prostaglandin El in a Lipid Emulsion by Ultrafiltration | Dirk L. Teagarden, Bradley D. Anderson and William J. Petre |
| 488-494 | Drug/Polymer Matrix Swelling and Dissolution | Ronald S. Harland, Andrea Gazzaniga, M. Edvige Sangalli, Paolo Colombo and Nikolaos A. Peppas |
| 495-500 | Dissolution Rate Studies from a Stationary Disk/Rotating Fluid System | Nahla Khoury, John W. Mauger and Stephen Howard |
| 501-505 | Mineral Metabolism of Aging Female Rats Fed Various Commercially Available Calcium Supplements or Yogurt | Alison R. Behling and Janet L. Greger |
| 506-508 | Turbuhaler: A New Powder Inhaler for Administration of Drugs to the Airways | Kjell Wetterlin |
| 509-513 | Comparative Pharmacokinetics of Methylprednisolone Phosphate and Hemisuccinate in High Doses | Helmut Möllmann, Peter Rohdewald, Jürgen Barth, Carsten Möllmann and Matthi Verho, et al. |
| 514-517 | An Accurate Prediction of the pH Change Due to Degradation: Correction for a “Produced” Secondary Buffering System | Leonard S. Rosenberg, Cheryl K. Hostetler, Dietmar M. Wagenknecht and Diane A. Aunet |
| 518-522 | Dynamics of Bromodeoxyuridine Incorporation into DNA of Squamous Carcinoma Cells During Mid and Late Logarithmic Growth | Amnon Shapira, John G. ***MISSING END TAG*** Ira S. Wagner, Jonathan Phillip L. Maybaum, William D. Ensminger and Thomas E. Carey |
| 523-527 | Formulation of Vaccine Adjuvant Muramyldipeptides (MDP). 1. Characterization of Amorphous and Crystalline Forms of a Muramyldipeptide Analogue | Tai Wah Chan and Allyn Becker |
| 528-532 | Formulation of Vaccine Adjuvant Muramyldipeptides (MDP). 2. The Thermal Reactivity and pH of Maximum Stability of MDP Compounds in Aqueous Solution | Michael F. Powell, Linda C. Foster, Allyn R. Becker and William Lee |
| 533-536 | Controlled Gastric Emptying. 1. Effects of Physical Properties on Gastric Residence Times of Nondisintegrating Geometric Shapes in Beagle Dogs | Robyn Cargill, Larry J. Caldwell, Karen Engle, Joseph A. Fix and Patricia A. Porter, et al. |
| 537-538 | Association News and Announcements |
| 623-627 | Glucocorticoid Receptors in Human Synovial Tissue and Relative Receptor Affinities of Glucocorticoid-21-Esters | Martin Pörtner, Helmut Möllmann and Peter Rohdewald |
| 628-633 | Cimetidine Elimination from the Cerebrospinal Fluid of the Rat | Mathew T. Whittico and Kathleen M. Giacomini |
| 634-638 | Potential Improvement in Shelf Life Using the Prodrug Approach. II. A Systematic Examination of Kinetic Requirements | Ngoc-Anh T. Nguyen and Robert E. Notari |
| 639-644 | Effects of Gender, Posture, and Age on Gastric Residence Time of an Indigestible Solid: Pharmaceutical Considerations | Parviz Mojaverian, Peter H. Vlasses, Paul E. Kellner and Mario L. Rocci |
| 645-650 | Characterization of the Oral Absorption of β-Lactam Antibiotics. I. Cephalosporins: Determination of Intrinsic Membrane Absorption Parameters in the Rat Intestine In Situ | Patrick J. Sinko and Gordon L. Amidon |
| 651-654 | Estimating Human Oral Fraction Dose Absorbed: A Correlation Using Rat Intestinal Membrane Permeability for Passive and Carrier-Mediated Compounds | Gordon L. Amidon, Patrick J. Sinko and David Fleisher |
| 655-659 | Complexation of Nifedipine with Substituted Phenolic Ligands | Kathleen M. Boje, Marion Sak and Ho-Leung Fung |
| 660-663 | The Relationship of pKa and Acute Skin Irritation in Man | Bret Berner, Donald R. Wilson, Richard H. Guy, Gerard C. Mazzenga and Frank H. Clarke, et al. |
| 664-667 | Determination of Spectinomycin Dihydrochloride by Liquid Chromatography with Electrochemical Detection | Lee Elrod, John F. Bauer and Stacy L. Messner |
| 668-672 | Correlation of Unbound Plasma Clearances of Fifteen Extensively Metabolized Drugs Between Humans and Rats | Win L. Chiou and Fung-Hwa Hsu |
| 673-676 | In Vitro Model for Ciclosporin Intestinal Absorption in Lipid Vehicles | Jean-Philippe Reymond and Heinz Sucker |
| 677-679 | In Vivo Model for Ciclosporin Intestinal Absorption in Lipid Vehicles | Jean-Philippe Reymond, Heinz Sucker and Jacky Vonderscher |
| 680-683 | The Measurement of Warfarin Enantiomers in Serum Using Coupled Achiral/Chiral, High-Performance Liquid Chromatography (HPLC) | Ya-Qin Chu and Irving W. Wainer |
| 684-686 | A Precolumn Derivatization High-Performance Liquid Chromatographic (HPLC) Procedure for the Quantitation of Difluoromethylornithine in Plasma | Jacquelyn Smithers |
| 687-688 | Association News and Announcements |
| 689-693 | The Adjuvant Effect of Bacitracin on Nasal Absorption of Gonadorelin and Buserelin in Rats | Susanne C. Raehs, Jürgen Sandow, Klaus Wirth and Hans P. Merkle |
| 694-698 | A Quantitative Method of Evaluating the Diuretic Response to Furosemide in Rats | Ryohei Hori, Katsuhiko Okumura, Ken-ichi Inui, Takashi Shibata and Toshihiro Kikkoji, et al. |
| 699-703 | Urinary Excretion and Diuretic Action of Furosemide in Rats: Increased Response to the Urinary Excretion Rate of Furosemide in Rats with Acute Renal Failure | Toshihiro Kikkoji, Akira Kamiya, Ken-ichi Inui and Ryohei Hori |
| 704-708 | Micellar Solubilization of Timobesone Acetate in Aqueous and Aqueous Propylene Glycol Solutions of Nonionic Surfactants | John T. H. Ong and Elizabeth Manoukian |
| 709-712 | Determination of Amiodarone Hydrochloride in Pharmaceutical Formulations by Derivative UV Spectrophotometry and High-Performance Liquid Chromatography (HPLC) | Anna M. Di Pietra, Vanni Cavrini, Rita Gatti and Maria A. Raggi |
| 713-717 | Amorphous Water-Soluble Cyclodextrin Derivatives: 2-Hydroxyethyl, 3-Hydroxypropyl, 2-Hydroxyisobutyl, and Carboxamidomethyl Derivatives of β-Cyclodextrin | Tetsumi Irie, Kazuhiro Fukunaga, Atsuya Yoshida, Kaneto Uekama and Henry M. Fales, et al. |
| 718-721 | Pharmacokinetics and Bioavailability of Hydromorphone: Effect of Various Routes of Administration | Shyi-Feu Chang, Luana Moore and Yie W. Chien |
| 722-725 | Thermal Behavior of Poly Hydroxy Ethyl Methacrylate (pHEMA) Hydrogels | Wouter E. Roorda, Johanna A. Bouwstra, Mattina A. de Vries and Hans E. Junginger |
| 726-728 | Experimental Confirmation of the Change of Water Structure in the Critical Range of Micelle Formation: A New Method of Critical Micelle Concentration (CMC) Determination | Reinhard Hüttenrauch, Sabine Fricke and Marion Köhler |
| 729-733 | The Reversibility of Absorption Promoter Interaction with Red Blood Cell Membranes Studied with Differential Scanning Calorimetry | Jurij Holinej, Howard Y. Ando and Julian W. Snow |
| 734-737 | Synthesis, Physicochemical Properties, and Cytotoxicity of a Series of 5′-Ester Prodrugs of 5-Iodo-2′-deoxyuridine | Milind M. Narurkar and Ashim K. Mitra |
| 738-740 | Effects of Dithiothreitol and Ascorbate on the Penetration of Diclofenac Across Excised Rat Dorsal Skin | Toshiaki Nishihata, J. Howard Rytting, Koich Takahashi and Kiyoshi Sakai |
| 741-744 | Nonenzymatic and Enzymatic Hydrolysis of 5-Fluoro-2′-deoxyuridine (FUdR) Esters | Takeo Kawaguchi, Shoji Fukushima, Yoshiki Hayashi and Masahiro Nakano |
| 745-747 | Renal Excretion and Metabolism of p-Aminohippurate in the Isolated Perfused Rat Kidney | Ling-Jar Lee and David E. Smith |
| 748 | Association News and Announcements |
| 749-752 | Exogenous Methemoglobin as a Cyanide Antidote in Rats | Garry W. Boswell, Daniel E. Brooks, Alison J. Murray, Angelia A. Doye and David J. Disselhorst, et al. |
| 753-758 | Physicochemical Aspects of Percutaneous Penetration and Its Enhancement | Richard H. Guy and Jonathan Hadgraft |
| 759-764 | In Vitro and In Vivo Studies Evaluating a Liposome System for Drug Solubilization | Deborah M. Lidgate, Philip L. Feigner, Jeffrey S. Fleitman, John Whatley and Roger Cherng-Chi Fu |
| 765-771 | Preformulation Stability Studies of the New Dipeptide Angiotensin-Converting Enzyme Inhibitor RS-10029 | Leo Gu and Robert G. Strickley |
| 772-775 | Limiting Solubilities and lonization Constants of Sparingly Soluble Compounds: Determination from Aqueous Potentiometric Titration Data Only | Adriaan P. IJzerman |
| 776-780 | The Effect of Compactional Pressure on Urease Activity | Ching-Ling Diana Teng and Michael J. Groves |
| 781-785 | An Implantable Pump for Intrarenal Infusion of Immunosuppressants in a Canine Autotransplant Model | Scott A. Gruber, Robert J. Cipolle, Daniel M. Canafax, Gary R. Erdmann and Barbara A. Burke, et al. |
| 786-789 | Enhancement of Colonic Drug Absorption by the Transcellular Permeation Route | Mikio Tomita, Masahiro Hayashi, Toshiharu Horie, Takayuki Ishizawa and Shoji Awazu |
| 790-794 | [Biocytin13]Dynorphin A 1-13 Amide: A Potential Probe for the κ-Opioid Receptor | Guenther Hochhaus, Andreas Patthy, Reinier Schwietert, Daniel V. Santi and Wolfgang Sadée |
| 795-799 | Agonist-Induced Substance P Receptor Down-Regulation in Rat Central Nervous System | Atsuko Inoue, Ryoko Takeda, Takeshi Fukuyasu, Yoshihiro Nakata and Tomio Segawa |
| 800-802 | Physical Stability of a Recombinant Alpha1-Antitrypsin Injection | Cheng-Der Yu, Niek Roosdorp and Shamim Pushpala |
| 803-805 | Phenobarbital Stability in Different Dosage Forms: Alternatives for Elixirs | Nancy J. Dietz, Peter J. Cascella, Joel E. Houglum, Gary S. Chappell and Ronald M. Sieve |
| 806 | Association News and Announcements |
| 807-808 | Reviewers for Pharmaceutical Research (1988) |
| 809-811 | Author Index to Volume 5 (1988) |
| 812-818 | Subject Index to Volume 5 (1988) |
| 1-3 | Benzodiazepines: Are They of Natural Origin? | Elisabeth Unseld and Ulrich Klotz |
| 4-12 | Application of Mean Residence-Time Concepts to Pharmacokinetic Systems with Noninstantaneous Input and Nonlinear Elimination | Haiyung Cheng and William J. Jusko |
| 13-19 | Phenotypic Differences in Dextromethorphan Metabolism | Santosh J. Vetticaden, Bernard E. Cabana, Vadlamani K. Prasad, Edward D. Purich and Jan H. J. Jonkman, et al. |
| 20-27 | Kinetics of Drug Decomposition by Heat Conduction Calorimetry | Lee D. Hansen, Edwin A. Lewis, Delbert J. Eatough, Robert G. Bergstrom and Damans DeGraft-Johnson |
| 28-32 | Isolation of a Novel Morphinan 3-O-Diglucuronide Metabolite from Dog Urine | Ross Dixon, Jane Hsiao, Hon-Bin Hsu, Maciej Smulkowski and Tze-Ming Chan, et al. |
| 33-39 | Transdermal Drug Transport and Metabolism. I. Comparison of In Vitro and In Vivo Results | Donald B. Guzek, Alane H. Kennedy, Stephen C. McNeill, E. Wakshull and Russell O. Potts |
| 40-43 | Enhanced Intestinal Absorption of Cyclosporine in Rats Through the Reduction of Emulsion Droplet Size | Bryan D. Tarr and Samuel H. Yalkowsky |
| 44-48 | Influence of Indomethacin Amphoteric Gel on Gastric Ulcerogenicity and Absorption of Indomethacin in Rats | Gary G. Liversidge, John Dent and W. Mark Eickhoff |
| 49-52 | Hollow Fibers as an Oral Sustained-Release Delivery System | Munir A. Hussain, Robert C. DiLuccio and Eli Shefter |
| 53-57 | Pharmacokinetics of Furegrelate After Oral Administration to Normal Humans | Duane B. Lakings, Janice M. Friis, Cynthia M. Lunan, James T. VanderLugt and J. Scott Mohrland |
| 58-61 | Complex Formation Between Metronidazole and Sodium Urate: Effect on Photodegradation of Metronidazole | Muhammed J. Habib and Ahmed F. Asker |
| 62-65 | Pharmacokinetics of Ketorolac and p-Hydroxyketorolac Following Oral and Intramuscular Administration of Ketorolac Tromethamine | Donald Jung, Edward J. Mroszczak, Anne Wu, Teck L. Ling and Hilli Sevelius, et al. |
| 66-70 | Use of the Peptide Carrier System to Improve the Intestinal Absorption of L-α-Methyldopa: Carrier Kinetics, Intestinal Permeabilities, and In Vitro Hydrolysis of Dipeptidyl Derivatives of L-α-Methyldopa | Ming Hu, Pullachipatti Subramanian, Henry I. Mosberg and Gordon L. Amidon |
| 71-77 | The Madin Darby Canine Kidney (MDCK) Epithelial Cell Monolayer as a Model Cellular Transport Barrier | Moo J. Cho, David P. Thompson, Clay T. Cramer, Thomas J. Vidmar and Jeffrey F. Scieszka |
| 78-84 | Neutrophil-Mediated Transport of Liposomes Across the Madin Darby Canine Kidney Epithelial Cell Monolayer | Moo J. Cho, Jeffrey F. Scieszka, Clay T. Cramer, David P. Thompson and Thomas J. Vidmar |
| 85-90 | lontophoretic Transport of a Homologous Series of Ionized and Nonionized Model Compounds: Influence of Hydrophobicity and Mechanistic Interpretation | Sam Del Terzo, Charanjit R. Behl and Robert A. Nash |
| 91-95 | Rectal Absorption Enhancement of Des-Enkephalin-γ-Endorphin (DEγE) by Medium-Chain Glycerides and EDTA in Conscious Rats | Ewoud J. van Hoogdalem, Cornelia D. Heijligers-Feijen, Albertus G. de Boer, J. Coos Verhoef and Douwe D. Breimer |
| 96-99 | Drug Delivery via Ion Exchange Across a Fiber Membrane | Dennis R. Jenke |
| 100-102 | Reversed-Phase High-Performance Liquid Chromatographic Analysis of Oligoglycines (One to Six Amino Acid Residues) | Ian G. Tucker, Martin E. Dowty, Michel Veillard, Mark A. Longer and Joseph R. Robinson |
| 103-104 | Association News and Announcements |
| 105-118 | Covalent and Noncovalent Protein Binding of Drugs: Implications for Hepatic Clearance, Storage, and Cell-Specific Drug Delivery | Dirk K. F. Meijer and Peter van der Sluijs |
| 119-124 | Transdermal Drug Transport and Metabolism. II. The Role of Competing Kinetic Events | Russell O. Potts, Stephen C. McNeill, Charlene R. Desbonnet and E. Wakshull |
| 125-132 | Procedures to Characterize In Vivo and In Vitro Enantioselective Glucuronidation Properly: Studies with Benoxaprofen Glucuronides | Hildegard Spahn, Seigo Iwakawa, Emil T. Lin and Leslie Z. Benet |
| 133-139 | The Area Function Method for Assessing the Drug Absorption Rate in Linear Systems with Zero-Order Input | Haiyung Cheng and William J. Jusko |
| 140-146 | Statistical Moment Analysis of Hepatobiliary Transport of Phenol Red in the Perfused Rat Liver | Koyo Nishida, Chiaki Tonegawa, Toshiyuki Kakutani, Mitsuru Hashida and Hitoshi Sezaki |
| 147-151 | Solubility Behavior of Narcotic Analgesics in Aqueous Media: Solubilities and Dissociation Constants of Morphine, Fentanyl, and Sufentanil | Samir D. Roy and Gordon L. Flynn |
| 152-155 | Radioreceptor Assay of Metoprolol in Human Plasma: Comparison with an Enantiospecific High-Performance Liquid Chromatographic (HPLC) Procedure | Hildegard Spahn, Anton Wellstein, Gabriele Pflugmann, Ernst Mutschler and Dieter Palm |
| 156-159 | Drug Binding to α1-Acid Glycoprotein Studied by Circular Dichroism | Masaki Otagiri, Ryuji Yamamichi, Toru Marayama, Teruko Imai and Ayaka Suenaga, et al. |
| 160-166 | Cultured Buccal Epithelium: An In Vitro Model Derived from the Hamster Pouch for Studying Drug Transport and Metabolism | M. Reza Tavakoli-Saberi and Kenneth L. Audus |
| 167-170 | An In Vitro Model to Evaluate Muscle Damage Following Intramuscular Injections | Gayle A. Brazeau and Ho-Leung Fung |
| 171-176 | Synthesis of Palmitoyl Derivatives of Insulin and Their Biological Activities | Muneaki Hashimoto, Kanji Takada, Yoshiaki Kiso and Shozo Muranishi |
| 177-181 | The Determination of Microscopic lonization Constants of a Substituted Piperazine Using Estimates from Model Compounds | Nivedita K. Pandit and John M. Sisco |
| 182-185 | Racial Differences in Drug Response: Isoproterenol Effects on Heart Rate in Healthy Males | David R. Rutledge, Lavoisier Cardozo and Joel D. Steinberg |
| 186-189 | The Use of α-Aminoboronic Acid Derivatives to Stabilize Peptide Drugs During Their Intranasal Absorption | Munir A. Hussain, Ashok B. Shenvi, Susan M. Rowe and Eli Shefter |
| 190 | Association News and Announcements |
| 191 | Editorial |
| 192-202 | Receptor-Mediated Transport of Peptide Hormones and Its Importance in the Overall Hormone Disposition in the Body | Yuichi Sugiyama and Manabu Hanano |
| 203-209 | Binding of Sulfonamides to Carbonic Anhydrase: Influence on Distribution Within Blood and on Pharmacokinetics | Alan Boddy, Phillip Edwards and Malcolm Rowland |
| 210-215 | Dehydration Kinetics of Prostaglandin E1 in a Lipid Emulsion | Dirk L. Teagarden, Bradley D. Anderson and William J. Petre |
| 216-224 | Synthesis and Biological Evaluation of Ether-Linked Derivatives of Phosphatidylinositol | Khalid S. Ishaq, Maria Capobianco, Claude Piantadosi, Alessandro Noseda and Larry W. Daniel, et al. |
| 225-229 | Optimized Inhalation Aerosols. I. The Effects of Spherical Baffle Size and Position upon the Output of Several Pressurized Nonaqueous Suspension Formulations | Peter R. Byron, Richard N. Dalby and Anthony J. Hickey |
| 230-234 | The Hypolipidemic Activity of l-N-3-Methylphthalimido-butan-3-semicarbazone in Rodents | Oi T. Wong, Iris H. Hall and James M. Chapman |
| 235-238 | Uptake of Colchicine, a Microtubular System Disrupting Agent, by Isolated Rat Hepatocytes | Konstanty Wierzba, Yuichi Sugiyama, Kazuho Okudaira, Tatsuji Iga and Manabu Hanano |
| 239-243 | Controlled Release of Steroids Through Microporous Membranes with Sodium Dodecyl Sulfate Micelles | Keith A. Johnson, Gerald B. Westermann-Clark and Dinesh O. Shah |
| 244-247 | Structure/Effect Studies of Fatty Acid Isomers as Skin Penetration Enhancers and Skin Irritants | Bruce J. Aungst |
| 248-251 | Nonlinear Distribution of Atenolol Between Plasma and Cerebrospinal Fluid | Francis M. Gengo, Susan C. Pagan, L. Nelson Hopkins, Debby Wagner and David P. Schuster |
| 252-254 | The Antiarrhythmic Activity of N- Alkyl-1,2-diphenylethanolamines | Kamal E. H. El Tahir, Humeida A. Al-Obeid, Khalid A. Al-Rashood, Abdul Azim E. Madani and Abdulrahman M. Ageel |
| 255-257 | The Effect of End-to-Side Portacaval Shunt on Cyclosporine Pharmacokinetics in Rats | Joachim Grevel, Paolo Rigotti, Franco Citterio, Mario Plebani and Barry D. Kahan |
| 258-261 | Mean Residence Time of Drugs Showing Simultaneous First-Order and Michaelis–Menten Elimination Kinetics | Haiyung Cheng and William J. Jusko |
| 262 | Association News and Announcements |
| 265-273 | Idiosyncratic Drug Reactions: Possible Role of Reactive Metabolites Generated by Leukocytes | Jack P. Uetrecht |
| 274-278 | Correlation of Phenylpropanolamine Bioavailability with Gastrointestinal Transit by Scintigraphic Monitoring of 111In-Labeled Hydroxypropylmethylcellulose Matrices | Liam C. Feely and Stanley S. Davis |
| 279-285 | Experimental Animal Models for Studying Antimicrobial Pharmacokinetics in Otitis Media | Daniel M. Canafax, Naobumi Nonomura, Gary R. Erdmann, Chap T. Le and Steven K. Juhn, et al. |
| 286-295 | New Alkyl N,N-Dialkyl-Substituted Amino Acetates as Transdermal Penetration Enhancers | Ooi Wong, James Huntington, Toshiaki Nishihata and J. Howard Rytting |
| 296-301 | Protein Precoating of Polylactide Microspheres Containing a Lipophilic Immunopotentiator for Enhancement of Macrophage Phagocytosis and Activation | Yasuhiko Tabata and Yoshito Ikada |
| 302-307 | Transport Characteristics of Ceftibuten (7432-S), a New Oral Cephem, in Rat Intestinal Brush-Border Membrane Vesicles: Proton-Coupled and Stereoselective Transport of Ceftibuten | Takayoshi Yoshikawa, Noriyuki Muranushi, Mariko Yoshida, Takayoshi Oguma and Koichiro Hirano, et al. |
| 308-312 | Transport Characteristics of Ceftibuten, a New Oral Cephem, in Rat Intestinal Brush-Border Membrane Vesicles: Relationship to Oligopeptide and Amino β-Lactam Transport | Noriyuki Muranushi, Takayoshi Yoshikawa, Mariko Yoshida, Takayoshi Oguma and Koichiro Hirano, et al. |
| 313-317 | Zero-Order Release Formulation of Oxprenolol Hydrochloride with Swelling and Erosion Control | Kanikanti Padmalatha Devi, Kanikanti V. Ranga Rao, Srikrishan Baveja, Marc Fathi and Marc Roth |
| 318-322 | Biologic Activity of 5′-Deoxy-5-fluorouridine by Rectal Administration | Steven L. Bramer, Lena C. Gunnarsson and J. Lai-Sim Au |
| 323-327 | Absorption of 5′-Deoxy-5-fluorouridine from Colon | J. Lai-Sim Au and Lena C. Gunnarsson |
| 328-331 | Intra- and Intersubject Variability: Mixed-Effects Statistical Analysis of Repeated Doses of an Angiotensin Converting Enzyme Inhibitor, CGS 16617 | Gregory M. Kochak, Robert A. Smith, R. Leslie Choi, Vivian John and Vijay Tipnis, et al. |
| 332-337 | Nutrient Influences on Rat Intestinal Phenytoin Uptake | David Fleisher, Neel Sheth, Heidi Griffin, Martin McFadden and Gregory Aspacher |
| 338-341 | Evaluation of Polyvinyl Alcohol Hydrogel as a Sustained-Release Vehicle for Rectal Administration of Indomethacin | Kazuhiro Morimoto, Atsushi Nagayasu, Shinichi Fukanoki, Katsuaki Morisaka and Suong-Hyu Hyon, et al. |
| 342-345 | Tissue Distribution of Cisplatin After Hepatic Arterial Injection of a Cisplatin–Lipiodol Suspension Containing Phosphatidylcholine to Rabbits Carrying VX-2 Hepatic Carcinoma | Mikiro Nakashima, Mihoko Nakano, Yoshikazu Ishii, Kenji Matsuyama and Masataka Ichikawa, et al. |
| 346-351 | In Vitro Release Profiles of Clonidine Transdermal Therapeutic Systems and Scopolamine Transdermal Patches | Vinod P. Shah, Norlin W. Tymes and Jerome P. Skelly |
| 352-353 | Association News and Announcements |
| 355-361 | Drug Delivery by Phonophoresis | Praveen Tyle and Praful Agrawala |
| 362-366 | Interactions Between Aminoglycosides and Phospholipids Using Liposomes: A Possible Mechanism of Nephrotoxicity | Yukihiko Aramaki and Seishi Tsuchiya |
| 367-372 | Efficiency of Drug Targeting: Steady-State Considerations Using a Three-Compartment Model | Alan Boddy, Leon Aarons and Karel Petrak |
| 373-378 | Evaluating the Fracture Toughness of Sucrose Crystals Using Microindentation Techniques | Wendy C. Duncan-Hewitt and George C. Weatherly |
| 379-386 | Multiple-Dose Pharmacokinetics and Pharmacodynamics of Adinazolam in Elderly Subjects | Joseph C. Fleishaker, J. Paul Phillips, Thomas C. Smith and Randall B. Smith |
| 387-393 | Kinetics of the Aspartyl Transpeptidation of Daptomycin, a Novel Lipopeptide Antibiotic | Lee E. Kirsch, R. Michael Molloy, Manual Debono, Patrick Baker and Khadiga Z. Farid |
| 394-398 | Study on the Renal and Cardiovascular Activities of Aminouracil Derivatives | Ali A. Mustafa, Abdulgader A. Alhaider and Abdullah A. Hijazi |
| 399-403 | Correlation of Partitioning of Nitroimidazoles in the n-Octanol/Saline and Liposome Systems with Pharmacokinetic Parameters and Quantitative Structure–Activity Relationships (QSAR) | Gurupadappa V. Betageri and James A. Rogers |
| 404-407 | Kinetics of Drug Action in Disease States. XXXI. Effect of Experimental Hyperthyroidism on the Hypnotic Activity of a Benzodiazepine (Oxazepam) in Rats | Judith S. Walker, Patricia M. Klockowski and Gerhard Levy |
| 408-412 | Preformulation Study of Etoposide: Identification of Physicochemical Characteristics Responsible for the Low and Erratic Oral Bioavailability of Etoposide | Jaymin C. Shah, Jivn R. Chen and Diana Chow |
| 413-417 | A Novel Approach to the Oral Delivery of Micro- or Nanoparticles | Roland Bodmeier, Huagang Chen and Ornlaksana Paeratakul |
| 418-421 | Effect of Drug (Core) Particle Size on the Dissolution of Theophylline from Microspheres Made from Low Molecular Weight Cellulose Acetate Propionate | Atul J. Shukla and James C. Price |
| 422-427 | Synthesis of Gelatin Microspheres Containing Interferon | Yasuhiko Tabata and Yoshito Ikada |
| 428-430 | Analysis of Diltiazem and Desacetyldiltiazem in Plasma Using Modified High-Performance Liquid Chromatography: Improved Sensitivity and Reproducibility | Hong Zhao and Moses S. S. Chow |
| 431-435 | In Vitro Diffusion Cell Design and Validation. I. A Stability-Indicating High-Performance Liquid Chromatographic Assay for Betamethasone 17-Valerate in Purified Isopropyl Myristate Receptor Phase | Eric W. Smith and John M. Haigh |
| 436-437 | Letter to the Editor | Kenneth J. Himmelstein |
| 438-439 | Letter to the Editor | Bernhard Palsson, Sadettin Ozturk and Jennifer B. Dressman |
| 440-441 | Association News and Announcements |
| 443-448 | Facilitated Transport of Basic and Acidic Drugs in Solutions Through Snakeskin by a New Enhancer—Dodecyl N,N-Dimethylamino Acetate | Christine Flecker, Ooi Wong and J. Howard Rytting |
| 449-457 | The Role of Calcium Ions and Bile Salts on the Pancreatic Lipase-Catalyzed Hydrolysis of Triglyceride Emulsions Stabilized with Lecithin | Francisco J. Alvarez and Valentine J. Stella |
| 458-465 | Stability of Phenobarbital N-Glucosides: Identification of Hydrolysis Products and Kinetics of Decomposition | Floyd B. Vest, William H. Soine, Richard B. Westkaemper and Phyllis J. Soine |
| 466-473 | Permeability and Mechanism of Albumin, Cationized Albumin, and Glycosylated Albumin Transcellular Transport Across Monolayers of Cultured Bovine Brain Capillary Endothelial Cells | Kevin R. Smith and Ronald T. Borchardt |
| 474-476 | Synthesis and Receptor Binding Studies of (±)l-Iodo-MK-801 | David J. Yang, Brian J. Ciliax, Marcian E. Van Dort, David L. Gildersleeve and Jean-Luc Pirat, et al. |
| 477-480 | Effect of the Immunomodulator Tilorone on the in Vivo Acetylation of Procainamide in the Rat | Craig K. Svensson and Philip W. Knowlton |
| 481-485 | Pharmacokinetics and Oral Bioavailability of Scopolamine in Normal Subjects | Lakshmi Putcha, Nitza M. Cintrón, James Tsui, James M. Vanderploeg and William G. Kramer |
| 486-491 | Prediction of the Distribution Volumes of Cefazolin and Tobramycin in Obese Children Based on Physiological Pharmacokinetic Concepts | Rie Koshida, Emi Nakashima, Noboru Taniguchi, Akira Tsuji and Leslie Z. Benet, et al. |
| 492-496 | Pharmacokinetics of Platinum in Cancer Patients Treated with Carboplatin in Combination with High-Dose Methotrexate | Adnan El-Yazigi, Magid Amer and Cazemiro R. Martin |
| 497-500 | Differential Molecular Connectivity in Data-Base Fragment Searching | Lemont B. Kier and Lowell H. Hall |
| 501-505 | Short-Chain Alkyl Esters of L-Dopa as Prodrugs for Rectal Absorption | Joseph A. Fix, Jose Alexander, Margot Cortese, Karen Engle and Paula Leppert, et al. |
| 506-509 | Controlled Gastric Emptying. II. In Vitro Erosion and Gastric Residence Times of an Erodible Device in Beagle Dogs | Robyn Cargill, Karen Engle, Colin R. Gardner, Patricia Porter and Randall V. Sparer, et al. |
| 510-516 | Side-Effect Evaluation of a New Diazepam Formulation: Venous Sequela Reduction Following Intravenous (iv) Injection of a Diazepam Emulsion in Rabbits | Menashe Yoram Levy, Lev Langerman, Shoshanna Gottschalk-Sabag and Simon Benita |
| 517-520 | Modification of Gelatin Beadlets for Zero-Order Sustained Release | Charles S. L. Chiao and James C. Price |
| 521-524 | Determination of Reserpine by Circular Dichroism | Kathy A. Swallows and Neil Purdie |
| 525-527 | Summary of Drug Needs in Cystic Fibrosis | Richard C. Boucher and Robert J. Beall |
| 528 | ERRATUM |
| 529 | Association News and Announcements |
| 531-554 | Current Aspects of Practical Two-Dimensional (2D) Nuclear Magnetic Resonance (NMR) Spectroscopy: Applications to Structure Elucidation | Richard W. Kriwacki and T. Phil Pitner |
| 555-563 | Pancreatic Lipase-Catalyzed Hydrolysis of Esters of Hydroxymethyl Phenytoin Dissolved in Various Metabolizable Vehicles, Dispersed in Micellar Systems, and in Aqueous Suspensions | Francisco J. Alvarez and Valentine J. Stella |
| 564-570 | Temperature Dependence of Non-Fickian Water Transport and Swelling in Glassy Gelatin Matrices | Cathy M. Klech and Jill H. Pari |
| 571-577 | Profile of in Vitro Binding Affinities of Neuroleptics at Different Rat Brain Receptors: Cluster Analysis Comparison with Pharmacological and Clinical Profiles | Rodolfo Testa, Gianalfredo Abbiati, Roberto Ceserani, Gianvico Restelli and Alessandro Vanasia, et al. |
| 578-584 | Effect of Polymeric Network Structure on Drug Release from Cross-Linked Poly(Vinyl Alcohol) Micromatrices | Bruno Gander, Robert Gurny, Eric Doelker and Nikolaos A. Peppas |
| 585-591 | Relationship Between Receptor Occupancy at 37°C and the Anticonvulsant Effect of Flunitrazepam in Rats | Marijke Hollander-Jansen, Jasper Dingemanse, Mariska W. E. Langemeijer and Meindert Danhof |
| 592-600 | Effects of a Brain-Enhanced Chemical Delivery System for Estradiol on Body Weight and Food Intake in Intact and Ovariectomized Rats | James W. Simpkins, Wesley R. Anderson, Ralph Dawson and Nicholas Bodor |
| 601-607 | Liposomal Formulation Eliminates Acute Toxicity and Pump Incompatibility of Parenteral Cyclosporine | Scott A. Gruber, Suresh Venkataram, Daniel M. Canafax, Robert J. Cipolle and Larry Bowers, et al. |
| 608-611 | Quantitative Fourier Transform-Infrared/Attenuated Total Reflectance (FT-IR/ATR) Analysis of Trimethoprim and Sulfamethoxazole in a Pharmaceutical Formulation Using Partial Least Squares | Kerry J. Hartauer and J. Keith Guillory |
| 612-618 | In Vitro Dissolution Profile of Water-Insoluble Drug Dosage Forms in the Presence of Surfactants | Vinod P. Shah, John J. Konecny, Richard L. Everett, Brace McCullough and A. Carol Noorizadeh, et al. |
| 619-623 | In Vitro Adsorption of Bile Salts by Colestipol Hydrochloride | Thomas J. Konechnik, Rosemary Kos, Joe L. White, Stanley L. Hem and Marie T. Borin |
| 624-627 | The Application of Bovine Brain Microvessel Endothelial-Cell Monolayers Grown onto Polycarbonate Membranes in Vitro to Estimate the Potential Permeability of Solutes Through the Blood–Brain Barrier | Mandar V. Shah, Kenneth L. Audus and Ronald T. Borchardt |
| 628-632 | Enhanced in Vitro Skin Permeation of Cationic Drugs | Philip G. Green, Jonathan Hadgraft and Geoffrey Ridout |
| 633-636 | The Influence of Liposomal Encapsulation on Sodium Cromoglycate Pharmacokinetics in Man | Kevin M. G. Taylor, Glyn Taylor, Ian W. Kellaway and John Stevens |
| 637-640 | Kmeriol and Other Aromatic Constituents of Kmeria Duperreana | Xiaoping Dong, Ing-On Mondranondra, Chun-tao Che, Harry H. S. Fong and Norman R. Farnsworth |
| 641-646 | Testosterone in a Cyclodextrin-Containing Formulation: Behavioral and Physiological Effects of Episode-like Pulses in Rats | George T. Taylor, Jürgen Weiss and Josef Pitha |
| 647-649 | Association News and Announcements |
| 651-659 | Endothelium-Derived Nitric Oxide: Pharmacology and Relationship to the Actions of Organic Nitrate Esters | Louis J. Ignarro |
| 660-666 | Route of Administration and Sex Differences in the Pharmacokinetics of Aspirin, Administered as Its Lysine Salt | Leon Aarons, Katie Hopkins, Malcolm Rowland, S. Brossel and Jean-François Thiercelin |
| 667-676 | Improved Delivery Through Biological Membranes. XXXVII. Synthesis and Stability of Novel Redox Derivatives of Naproxen and Indomethacin | Michael J. Phelan and Nicholas Bodor |
| 677-682 | A Pharmacokinetic Model of Intravenously Administered Hyaluronan in Sheep | Lena Lebel, J. Robert E. Fraser, Wayne S. Kimpton, Johan Gabrielsson and Bengt Gerdin, et al. |
| 683-689 | Structure–Pharmacokinetic Relationships in a Series of Valpromide Derivatives with Antiepileptic Activity | Abdulla Haj-Yehia and Meir Bialer |
| 690-696 | Saturable Process Involved in Active Efflux of Vincristine as a Mechanism of Multidrug Resistance in P388 Leukemia Cells | Tohru Watanabe, Makoto Inaba and Yuichi Sugiyama |
| 697-701 | The Effect of Ultrasound on the in Vitro Penetration of Ibuprofen Through Human Epidermis | Richard Brucks, Maulik Nanavaty, Donald Jung and Frederick Siegel |
| 702-705 | A Retrospective Analysis of Fenoldopam Renal Excretion in 65 Subjects: Evidence for Possible Intrarenal Formation of Fenoldopam from Its Metabolites | John A. Ziemniak, Venkata K. Boppana, Matthew J. Cyronak and Robert M. Stote |
| 706-708 | A Nuclear Magnetic Resonance (NMR) Method for the Determination of the cis/trans Isomeric Content of Chlorprothixene | Karl-Heinz A. Rosler, Jeremy Wright, Kristine M. Fox, Rolland M. Waters and Patrick S. Callery |
| 709-713 | A Comparison of the Cholinergic Activity of Selected H2-Antagonists and Sulfoxide Metabolites | Joseph W. Kosh, J. Walter Sowell and James M. Chapman |
| 714-718 | Nylon Microcapsules. II. Effect of Selected Variables on Theophylline Release | P. L. Madan and P. Chareonboonsit |
| 719-724 | Gastrointestinal Transit of a Solid Indigestible Capsule as Measured by Radiotelemetry and Dual Gamma Scintigraphy | Parviz Mojaverian, Keith Chan, Anil Desai and Vivian John |
| 725-730 | Evaluation of Drug-Containing Polymer Films Prepared from Aqueous Latexes | Roland Bodmeier and Ornlaksana Paeratakul |
| 731-733 | Noncompartmental Analysis for a One-Compartment Model with Equal Absorption and Elimination Rate Constants | Howard Ko, James F. Caputo and Wade J. Adams |
| 734-736 | Dose-Ranging Pharmacokinetics of Zidovudine (Azidothymidine) in the Rat | Jashvant D. Unadkat, Ji Ping Wang, David Pulham and Robin L. O. Semmes |
| 737-739 | Phosphorus–Nitrogen Compounds. 31. N-Phosphinylamino-1,2,5,6-tetrahydropyridines: Analgesic Activity and Effect on Blood Glucose | Lindley A. Cates, Ven-Shun Li and Sharathchandra S. Hegde |
| 740-741 | A Simple Microwave Technique for the Separation of Epidermis and Dermis in Skin Uptake Studies | Saran Kumar, Charan R. Behl, Sunil B. Patel and A. Waseem Malick |
| 742 | Association News and Announcements |
| 743-747 | Ion Pair Transport Across Membranes | Reinhard Neubert |
| 748-752 | Formulation of Vaccine Adjuvant Muramyldipeptides. 3. Processing Optimization, Characterization, and Bioactivity of an Emulsion Vehicle | Deborah M. Lidgate, Roger C. Fu, Noelene E. Byars, Linda C. Foster and Jeffrey S. Fleitman |
| 753-758 | Transdermal Controlled Delivery of Propranolol from a Multilaminate Adhesive Device | Michael Corbo, Jue-Chen Liu and Yie W. Chien |
| 759-765 | Evidence for Site-Specific Absorption of a Novel ACE Inhibitor | George M. Grass and William T. Morehead |
| 766-771 | Use of an in Vitro Model for the Assessment of Muscle Damage from Intramuscular Injections: in Vitro-in Vivo Correlation and Predictability with Mixed Solvent Systems | Gayle A. Brazeau and Ho-Leung Fung |
| 772-778 | The Kinetics of Timolol in the Rabbit Lens: Implications for Ocular Drug Delivery | Imran Ahmed, Michael L. Francoeur, Avinash G. Thombre and Thomas F. Patton |
| 779-786 | Amino Acids Bracketing the Predicted Transmembrane Domains of Membrane Proteins | Charles Pidgeon, Renee L. Williard and Susan C. Schroeder |
| 787-793 | Chloroquine Blood Levels After Administration of the Liposome-Encapsulated Drug in Relation to Therapy of Murine Malaria | Pierre A. M. Peeters, Karen de Leest, Wijnand M. C. Eling and Daan J. A. Crommelin |
| 794-797 | Effect of Anions on Adsorption of Bile Salts by Colestipol Hydrochloride | Christine V. Bilicki, Joe L. White, Stanley L. Hem and Marie T. Borin |
| 798-803 | Dose-Dependent Enhancement Effects of Azone on Skin Permeability | William J. Lambert, William I. Higuchi, Kristine Knutson and Steven L. Krill |
| 804-808 | Solid-State Interaction of Magnesium Oxide and Ibuprofen to Form a Salt | Tugrul T. Kararli, Thomas E. Needham, Clifford J. Seul and Pat M. Finnegan |
| 809-812 | A Graph-Theoretical Approach to the Prediction of Physical Properties of Alkanes Based on the Distance Matrix | James F. Caputo and Kathleen J. Cook |
| 813-816 | Enhanced Bioavailability of Subcutaneously Injected Insulin Coadministered with Collagen in Rats and Humans | Ryohei Hori, Fusao Komada, Seigo Iwakawa, Yutaka Seino and Katsuhiko Okumura |
| 817-821 | Estimation of Bioavailability on a Single Occasion After Semisimultaneous Drug Administration | Mats O. Karlsson and Ulf Bredberg |
| 822-823 | Association News and Announcements |
| 825-832 | Transdermal Delivery of Narcotic Analgesics: Comparative Permeabilities of Narcotic Analgesics Through Human Cadaver Skin | Samir D. Roy and Gordon L. Flynn |
| 833-839 | Erythrocytes as Barriers for Drug Elimination in the Isolated Rat Liver. I. Doxorubicin | Hye-Jung Lee and Win L. Chiou |
| 840-843 | Erythrocytes as Barriers for Drug Elimination in the Isolated Rat Liver. II. Propranolol | Hye-Jung Lee and Win L. Chiou |
| 844-847 | Polyvinyl Alcohol–Methyl Acrylate Copolymers as a Sustained-Release Oral Delivery System | Robert C. DiLuccio, Munir A. Hussain, David CoffinBeach, George Torosian and Eli Shefter, et al. |
| 848-852 | Drug Absorption Through Mucosal Membranes: Effect of Mucosal Route and Penetrant Hydrophilicity | Diane C. Corbo, Jue-Chen Liu and Yie W. Chien |
| 853-856 | Absorption Enhancement of Intranasally Administered Insulin by Sodium Taurodihydrofusidate (STDHF) in Rabbits and Rats | Marc J. M. Deurloo, Walter A. J. J. Hermens, Stefan G. Romeyn, J. Coos Verhoef and Frans W. H. M. Merkus |
| 857-862 | A Correlation of Permeabilities for Passively Transported Compounds in Monkey and Rabbit Jejunum | George M. Grass and Stephanie A. Sweetana |
| 863-866 | Effect of Uridine Diphosphoglucose on Levels of 5-Phosphoribosyl Pyrophosphate and Uridine Triphosphate in Murine Tissues | Joseph R. Colofiore, Robert C. Sawyer, M. Earl Balis and Daniel S. Martin |
| 867-873 | Synthesis and Biological Evaluation of Ω-(N,N,N-Trialkylammonium)alkyl Esters and Thioesters of Carboxylic Acid Nonsteroidal Antiinflammatory Agents | Michael C. Venuti, John M. Young, Patrick J. Maloney, David Johnson and Kenneth McGreevy |
| 874-876 | Influence of Unbound Fraction and Perfusate Flow Rate on Taurocholate Elimination by Perfused Rat Liver: Applicability of Three Distributed Models | Denis J. Morgan |
| 877-882 | Contribution of Monoamine Oxidase (MAO) to the Binding of Tertiary Basic Drugs in Lung Mitochondria | Hisahiro Yoshida, Akira Kamiya, Katsuhiko Okumura and Ryohei Hori |
| 883-886 | Antiperspirant Activity of H1-Histamine Blockers as Determined by a Modified Rat Foot Pad Assay | Michael D. Helman, Thomas A. Re and Alison B. Lukacsko |
| 887-891 | Prodrugs of 5-Iodo-2′-Deoxyuridine for Enhanced Ocular Transport | Milind M. Narurkar and Ashim K. Mitra |
| 892-894 | Gas Chromatographic/Mass Spectrometric (GC/MS) Analysis of N-Nitrosodiisopropanolamine at the Nanogram-per-Gram Level in a Gel Formulation Containing a Nonsteroidal Antiinflammatory Agent | John C. James, Michael J. Pastel, Katherine A. Ledoux and John M. Baldoni |
| 895-899 | Analytical Method for the Quantification of 2′,3′-Didehydro-3′-Deoxythymidine, a New Anti-Human Immunodeficiency Virus (HIV) Agent, by High-Performance Liquid Chromatography (HPLC) and Ultraviolet (UV) Detection in Rat and Monkey Plasma | Sanjeev Kaul, Kishor A. Dandekar and Kenneth A. Pittman |
| 900 | BOOK REVIEWS |
| 901 | Association News and Announcements |
| 903-918 | Stability of Protein Pharmaceuticals | Mark C. Manning, Kamlesh Patel and Ronald T. Borchardt |
| 919-923 | Macromolecular Prodrugs. XV. Colon-Targeted Delivery—Bioavailability of Naproxen from Orally Administered Dextran–Naproxen Ester Prodrugs Varying in Molecular Size in the Pig | Elin Harboe, Claus Larsen, Marianne Johansen and Henning Peter Olesen |
| 924-932 | Quantitative Whole-Body Autoradiographic Determination of Tacrine Tissue Distribution in Rats Following Intravenous or Oral Dose | William McNally, Michelle Roth, Remedios Young, Howard Bockbrader and Tsun Chang |
| 931-937 | Analysis of Drug Penetration Through the Skin by the Two-Layer Skin Mode | Hirokazu Okamoto, Fumiyoshi Yamashita, Kyoko Saito and Mitsuru Hashida |
| 938-944 | Transdermal Delivery of Levonorgestrel. V. Preparation of Devices and Evaluation in Vitro | David R. Friend, Paul Catz, Jorge Heller and Michael Okagaki |
| 945-948 | Design and in Vitro Evaluation of Dapsone-Loaded Micropellets of Ethyl Cellulose | Suranjana Roy, Sudip K. Das, Manjusree Pal and Bijan K. Gupta |
| 949-953 | Assessment of Skin Barrier Function Using Transepidermal Water Loss: Effect of Age | Kathleen V. Roskos and Richard H. Guy |
| 954-957 | Decreased Transport of p-Aminohippurate in Renal Basolateral Membranes Isolated from Rats with Acute Renal Failure | Ken-ichi Inui, Mikihisa Takano, Hitoshi Maegawa, Miyako Kato and Ryohei Hori |
| 958-960 | Solid Surfactant Solutions of Active Ingredients in Sugar Esters | Lorenz Hahn and Heinz Sucker |
| 961-965 | Near-Infrared Spectroscopic Determination of Residual Moisture in Lyophilized Sucrose Through Intact Glass Vials | Madhav S. Kamat, Robert A. Lodder and Patrick P. DeLuca |
| 966-970 | Buccal Absorption. III. Simultaneous Diffusion and Metabolism of an Aminopeptidase Substrate in the Hamster Cheek Pouch | Kevin W. Garren, Elizabeth M. Topp and A. J. Repta |
| 971-975 | An Unexpected pH Effect on the Stability of Moexipril Lyophilized Powder | Robert G. Strickley, Gary C. Visor, Li-Hwa Lin and Leo Gu |
| 976-981 | Gender Differences in the Pharmacodynamics of Barbiturates in Rats | Amnon Hoffman and Gerhard Levy |
| 982-987 | Microbial Models of Mammalian Metabolism: Stereoselective Metabolism of Warfarin in the Fungus Cunninghamella elegans | Yiu W. J. Wong and Patrick J. Davis |
| 988-990 | Noninvasive Sampling of Biological Fluids by Iontophoresis | Peretz Glikfeld, Robert S. Hinz and Richard H. Guy |
| 991-993 | High-Performance Liquid Chromatographic Determination and Pharmacokinetics of Methyl N-[5[[4-(2-Pyridinyl)-l-piperazinyl]carbonyl]-1H-benzimidazol-2-yl] Carbamate (CDRI Compound 81-470), a New Anthelmintic Agent in Rats | Jyoti Kumar Paliwal, Ram Chandra Gupta and Pyara Krishen Grover |
| 994 | Association News and Announcements |
| 995-999 | Macromolecular Prodrugs. XVI. Colon-Targeted Delivery—Comparison of the Rate of Release of Naproxen from Dextran Ester Prodrugs in Homogenates of Various Segments of the Pig Gastrointestinal (GI) Tract | Claus Larsen, Elin Harboe, Marianne Johansen and Henning Peter Olesen |
| 1000-1010 | Transdermal Dual-Controlled Delivery of Contraceptive Drugs: Formulation Development, in Vitro and in Vivo Evaluations, and Clinical Performance | Yie W. Chien, Te-yen Chien, Robert E. Bagdon, Yih C. Huang and Robert H. Bierman |
| 1011-1016 | Noninvasive Assessment of Lipid Disposition in Treated and Untreated Atherosclerotic Rabbits | Laura E. DeForge, Susan W. Schwendner, Mark R. DeGalan, Daniel S. McConnell and Raymond E. Counsell |
| 1017-1024 | Determination of the Relative Amounts of Anhydrous Carbamazepine (C15H12N2O) and Carbamazepine Dihydrate (C15H12N2O · 2H2O) in a Mixture by Powder X-ray Diffractometry | Raj Suryanarayanan |
| 1025-1031 | Intrahepatic Delivery of Glutathione by Conjugation to Dextran | Yoshiharu Kaneo, Yumie Fujihara, Tetsuro Tanaka, Yoko Kozawa and Hideki Mori, et al. |
| 1032-1038 | Dextrose Adduct Formation in Aqueous Teicoplanin Solutions | William H. Streng and Nicholas W. Brake |
| 1039-1042 | The Beagle Dog as an Animal Model for a Bioavailability Study of Controlled-Release Theophylline Under the Influence of Food | Gerald K. Shiu, Armelle LeMarchand, Arlan O. Sager, Raja B. Velagapudi and Jerome P. Skelly |
| 1043-1047 | Passive and Carrier-Mediated Intestinal Absorption Components of Two Angiotensin Converting Enzyme (ACE) Inhibitor Prodrugs in Rats: Enalapril and Fosinopril | Doron I. Friedman and Gordon L. Amidon |
| 1048-1051 | High Performance Liquid Chromatographic (HPLC) Determination of Centchroman in Human Serum and Application to Single-Dose Pharmacokinetics | Jyoti Kumar Paliwal, Ram Chandra Gupta, Pyara Krishen Grover, Omkar P. Asthana and Jagdishwar Sahai Srivastava, et al. |
| 1052-1055 | Hollow Fibers as an Oral Sustained-Release Delivery System Using Propranolol Hydrochloride | Munir A. Hussain, Robert C. DiLuccio, Eli Shefter and Arthur R. Hurwitz |
| 1056-1059 | Effect of a Change in the Luminal Perfusion Rate on Intestinal Drug Absorption Studied by a Simple Unified Organ Clearance Approach | Win L. Chiou |
| 1060-1066 | Evaluating the Deformation Kinetics of Sucrose Crystals Using Microindentation Techniques | Wendy C. Duncan-Hewitt and George C. Weatherly |
| 1067-1072 | Pharmacokinetics of Sulfasalazine Metabolites in Rats Following Concomitant Oral Administration of Riboflavin | Vinod S. Chungi, Lewis W. Dittert and Leon Shargel |
| 1073 | Association News and Announcements |
| 1074-1076 | Reviewers for Pharmaceutical Research (1989) |
| 1077-1079 | Author Index to Volume 6 (1989) |
| 1080-1088 | Subject Index to Volume 6 (1989) |
| 1-7 | Amplification of Butyrylcholinesterase and Acetylcholinesterase Genes in Normal and Tumor Tissues: Putative Relationship to Organophosphorous Poisoning | Hermona Soreq and Haim Zakut |
| 8-13 | Solute Absorption from the Airways of the Isolated Rat Lung. II. Effect of Surfactants on Absorption of Fluorescein | Ralph W. Niven and Peter R. Byron |
| 14-20 | Pharmacokinetics of Methylergometrine in the Rat: Evidence for Enterohepatic Recirculation by a Linked-Rat Model | Ulf Bredberg and Lennart Paalzow |
| 21-27 | Irreversible Binding of Tolmetin Glucuronic Acid Esters to Albumin in Vitro | Alain Munafo, Antony F. McDonagh, Philip C. Smith and Leslie Z. Benet |
| 28-33 | Conversion of Ouabain-Induced Ventricular Tachycardia in Dogs with Epicardial Lidocaine: Pharmacodynamics and Functional Effects | Amnon Sintov, William A. Scott, Kim P. Gallagher and Robert J. Levy |
| 34-40 | Enhancement of the in Vitro Skin Permeability of Azidothymidine (AZT) via Iontophoresis and Chemical Enhancer | Lorraine Wearley and Yie W. Chien |
| 41-45 | Differential Effects of Anesthetic Regimens on Gentamicin Pharmacokinetics in the Rat: A Comparison with Chronically Catheterized Conscious Animals | Mark Gumbleton, Paul J. Nicholls and Glyn Taylor |
| 46-48 | High-Fat Meals Increase the Clearance of Cyclosporine | Suneel K. Gupta and Leslie Z. Benet |
| 49-53 | Mucoadhesion of Hydroxypropylmethacrylate Nanoparticles to Rat Intestinal Ileal Segments in Vitro | Clara Pimienta, Vincent Lenaerts, Céline Cadieux, Philippe Raymond and Julianna Juhasz, et al. |
| 54-58 | Plasma Concentrations of Remoxipride and the Gastrointestinal Transit of 111ln-Marked Extended-Release Coated Spheres | Christina Graffner, Zoltan Wagner, Maj-Inger Nilsson and Erik Widerlöv |
| 59-63 | Effects of First-Pass Metabolism on Metabolite Mean Residence Time Determination After Oral Administration of Parent Drug | Keith K. H. Chan and Milo Gibaldi |
| 64-68 | Percutaneous Penetration of Acyclovir Through Excised Hairless Mouse and Rat Skin: Effect of Vehicle and Percutaneous Penetration Enhancer | Hirokazu Okamoto, Kenji Muta, Mitsuru Hashida and Hitoshi Sezaki |
| 69-75 | Model of Disposition of Drugs Administered into the Human Nasal Cavity | Igor Gonda and Elizabeth Gipps |
| 76-79 | Effects of Variation in Drug Elimination on Five Methods for Assessing Zero-Order Drug Absorption Rates | Haiyung Cheng and William J. Jusko |
| 80-86 | Intrinsic Dissolution Rates of Tablet Filler-Binders and Their Influence on the Dissolution of Drugs from Tablet Formulations | Arun D. Koparkar, Larry L. Augsburger and Ralph F. Shangraw |
| 87-90 | The Biliary Elimination and Enterohepatic Circulation of Ibuprofen in Rats | Klaus Dietzel, Winfried S. Beck, Hans-Th. Schneider, Gerd Geisslinger and Kay Brune |
| 91-95 | Effect of Aliphatic Side-Chain Substituents on the Antimalarial Activity and on the Metabolism of Primaquine Studied Using Mitochondria and Microsome Preparations | John K. Baker, Robert H. Yarber, N. P. D. Nanayakkara, James D. McChesney and Frederic Homo, et al. |
| 96-102 | The Effects of Urine pH Modification on the Pharmacokinetics and Pharmacodynamics of Phenylpropanolamine | Cheryl L. Zimmerman, Mary Beth O'Connell and Inmaculada Soria |
| 103-107 | Mean Residence Times of Multicompartmental Drugs Undergoing Reversible Metabolism | Haiyung Cheng and William J. Jusko |
| 108-109 | Reimbursement for Drugs Under Third-Party Programs | Francis B. Palumbo |
| 110 | BOOK REVIEWS |
| 111 | Editorial |
| 112 | Association News and Announcements |
| 113-117 | Percolation Theory and Compactibility of Binary Powder Systems | Dieter Blattner, Max Kolb and Hans Leuenberger |
| 118-126 | Transport Mechanisms in Iontophoresis. I. A Theoretical Model for the Effect of Electroosmotic Flow on Flux Enhancement in Transdermal Iontophoresis | Michael J. Pikal |
| 127-133 | Bile Salt–Fatty Acid Mixed Micelles as Nasal Absorption Promoters of Peptides. I. Effects of Ionic Strength, Adjuvant Composition, and Lipid Structure on the Nasal Absorption of [D-Arg2]Kyotorphin | Parkpoom Tengamnuay and Ashim K. Mitra |
| 134-143 | DC Electrical Properties of Frozen, Excised Human Skin | Gerald B. Kasting and Lisa A. Bowman |
| 144-146 | Effects of Absorption Enhancers on Human Nasal Tissue Ciliary Movement in Vitro | Walter A. J. J. Hermens, Piet M. Hooymans, J. Coos Verhoef and Frans W. H. M. Merkus |
| 147-153 | Solid-State Chemistry and Crystal Structure of Cefaclor Dihydrate | Heriberto Martinez, Stephen R. Byrn and Ralph R. Pfeiffer |
| 154-160 | Method Validation Revisited: A Chemometric Approach | Mario J. Cardone, Susan A. Willavize and Mark E. Lacy |
| 161-166 | Bioavailability Improvement of Mycophenolic Acid Through Amino Ester Derivatization | William A. Lee, Leo Gu, Andrew R. Miksztal, Nancy Chu and Kwan Leung, et al. |
| 167-169 | Effect of Molecular Weight on the Lymphatic Absorption of Water-Soluble Compounds Following Subcutaneous Administration | Andreas Supersaxo, Wayne R. Hein and Hans Steffen |
| 170-175 | Mechanism of Ethanol-Enhanced Estradiol Permeation Across Human Skin in Vivo | Lynn K. Pershing, Lyssa D. Lambert and Kristine Knutson |
| 176-179 | Determination of Potential Migrants from Commercial Amber Polyethylene Terephthalate Bottle Wall | Heasook Kim, Seymour G. Gilbert and James B. Johnson |
| 180-183 | Absorption Enhancement of Rectally Infused Insulin by Sodium Tauro-24,25-Dihydrofusidate (STDHF) in Rats | Ewoud J. van Hoogdalem, Corrie D. Heijligers-Feijen, J. Coos Verhoef, Albertus G. de Boer and Douwe D. Breimer |
| 184-187 | Quantitation of the Relative Amounts of Anhydrous Carbamazepine (C15H12N2O) and Carbamazepine Dihydrate (C15H12N2O · 2H2O) in a Mixture by Solid-State Nuclear Magnetic Resonance (NMR) | Raj Suryanarayanan and Timothy S. Wiedmann |
| 188-191 | Disposition of Bismuth in the Rat. I. Red Blood Cell and Plasma Protein Binding | Niranjan Rao and Stuart Feldman |
| 192-198 | Pharmacokinetics of the Aldose Reductase Inhibitor Imirestat Following Topical Ocular Administration | R. Kim Brazzell, C. Bradley Wooldridge, Robert B. Hackett and Bette A. McCue |
| 199-203 | Microbial Metabolism Studies of the Antimalarial Drug Arteether | Ik-Soo Lee, Hala N. ElSohly and Charles D. Hufford |
| 204-207 | Disposition of Antipyrine and Acetaminophen Given Alone and in Combination to Human Subjects | Walid M. Awni, John V. St. Peter, John M. Kovarik and Gary R. Matzke |
| 208 | BOOK REVIEWS |
| 209 | BOOK REVIEWS |
| 210 | ERRATUM |
| 211-212 | Association News and Announcements |
| 213-221 | Transport Mechanisms in Iontophoresis. II. Electroosmotic Flow and Transference Number Measurements for Hairless Mouse Skin | Michael J. Pikal and Saroj Shah |
| 222-229 | Transport Mechanisms in Iontophoresis. III. An Experimental Study of the Contributions of Electroosmotic Flow and Permeability Change in Transport of Low and High Molecular Weight Solutes | Michael J. Pikal and Saroj Shah |
| 230-236 | Percutaneous Absorption of Benzoic Acid Across Human Skin. I. In Vitro Experiments and Mathematical Modeling | Gregory E. Parry, Annette L. Bunge, Geoffrey D. Silcox, Lynn K. Pershing and David W. Pershing |
| 237-241 | Disposition of Bismuth in the Rat. II. Pharmacokinetics and Biliary Excretion | Niranjan Rao and Stuart Feldman |
| 242-246 | Kinetics of Drug Action in Disease States. XXXIX. Effect of Orally Administered Activated Charcoal on the Hypnotic Activity of Phenobarbital and the Neurotoxicity of Theophylline Administered Intravenously to Rats with Renal Failure | Amnon Hoffman and Gerhard Levy |
| 247-250 | The Effect of Compactional Pressure on a Wheat Germ Lipase Preparation | M. Hossein Zarrintan, C. Diana Teng and Michael J. Groves |
| 251-255 | Carboxylic Ester Hydrolase Activity in Hairless and Athymic Nude Mouse Skin | Mridul K. Ghosh and Ashim K. Mitra |
| 256-261 | Effect of Antihepatotoxic Agents Against Microcystin-LR Toxicity in Cultured Rat Hepatocytes | Kay A. Mereish and Rikki Solow |
| 260-263 | Antiendotoxin Activity of Lipid A Analogues: Requirements of the Chemical Structure | Robert L. Danner, Alan L. Van Dervort, Martin E. Doerfler, Peter Stuetz and Joseph E. Parrillo |
| 264-269 | Manufacture and Properties of Erythromycin Beads Containing Neutron-Activated Erbium-171 | Alan F. Parr, George A. Digenis, Erik P. Sandefer, Isaac Ghebre-Sellassie and Uma Iyer, et al. |
| 270-273 | Microbial Biotransformation of Retinoic Acid by Cunninghamella echinulata and Cunninghamella blakesleeana | David A. Hartman, Jack B. Basil, Larry W. Robertson and Robert W. Curley |
| 274-279 | Hydralazine Pharmacokinetics and Interaction with Food: An Evaluation of the Dog as an Animal Model | Hugh A. Semple, Yun K. Tam and Ronald T. Coutts |
| 280-282 | Interactions of 7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)-propoxy]-2(lH)-quinolinone (OPC-4392) with 3H-Spiperone and 3H-SCH 23390 Binding in Rat Striatum: Effects of Lesions | Xiao Zhang, Yoshihiro Nakata, Tetsuro Kikuchi and Tomio Segawa |
| 283-288 | Are Reduction Potentials of Antifungal Agents Relevant to Activity? | Peter Kovacic, Patrick F. Kiser and Benjamin A. Feinberg |
| 289-292 | Applications of Oxygen Polarography to Drug Stability Testing and Formulation Development: Solution-Phase Oxidation of Hydroxymethylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors | Michael J. Kaufman |
| 293-298 | Transport of Desglycinamide-Arginine Vasopressin Across the Blood–Brain Barrier in Rats as Evaluated by the Unit Impulse Response Methodology | Joost B. M. M. van Bree, Susan Tio, Albertus G. de Boer, J. Coos Verhoef and Douwe D. Breimer |
| 299-303 | Mechanism of Acyclovir Uptake in Rat Jejunum | Kem C. Meadows and Jennifer B. Dressman |
| 304-307 | The Effect of Food on Gastrointestinal (GI) Transit of Sustained-Release Ibuprofen Tablets as Evaluated by Gamma Scintigraphy | Marie T. Borin, Subhash Khare, Robert M. Beihn and Michael Jay |
| 308-309 | Mechanism of Absorption of the Dipeptide α-Methyldopa-phe in Intestinal Brush-Border Membrane Vesicles | Akira Tsuji, Ikumi Tamai, Masaru Nakanishi and Gordon L. Amidon |
| 310-312 | Association News and Announcements |
| 313-317 | Sustained-Release Delivery Systems for Treatment of Dental Diseases | Michael Friedman and Doron Steinberg |
| 318-324 | Altered Pharmacokinetics and Dynamics of Apomorphine in the Malnourished Rat: Modeling of the Composed Relationship Between Concentration and Heart-Rate Response | Eva Bredberg and Lennart K. Paalzow |
| 325-331 | Transepithelial Transport of Aliphatic Carboxylic Acids Studied in Madin Darby Canine Kidney (MDCK) Cell Monolayers | Moo J. Cho, Anthony Adson and F. J. Kezdy |
| 332-338 | Modeling the Enhanced Uptake of Zidovudine (AZT) into Cerebrospinal Fluid. 1. Effect of Probenecid | Ronald J. Sawchuk and Mohsen A. Hedaya |
| 339-346 | Disposition Characteristics of Macromolecules in Tumor-Bearing Mice | Yoshinobu Takakura, Takuya Fujita, Mitsuru Hashida and Hitoshi Sezaki |
| 347-351 | Single- vs Multiple-Dose Pharmacokinetics of Clozapine in Psychiatric Patients | Miles G. Choc, Francis Hsuan, Gilbert Honigfeld, William T. Robinson and Larry Ereshefsky, et al. |
| 352-358 | Percutaneous Absorption of Benzoic Acid Across Human Skin. II. Prediction of an in Vivo, Skin-Flap System Using in Vitro Parameters | Geoffrey D. Silcox, Gregory E. Parry, Annette L. Bunge, Lynn K. Pershing and David W. Pershing |
| 359-363 | Formulation and in Vitro-in Vivo Evaluation of Sustained-Release Lithium Carbonate Tablets | Kadriye Çiftçi, Yilmaz Çapan, Orhan Öztürk and A. Atilla Hincal |
| 364-369 | Epimerization Kinetics of Moxalactam in Frozen Urine and Plasma Samples | Naofumi Hashimoto, Teruhisa Ichihashi, Koichiro Hirano and Hideo Yamada |
| 370-375 | Bile Salt–Fatty Acid Mixed Micelles as Nasal Absorption Promoters of Peptides. II. In Vivo Nasal Absorption of Insulin in Rats and Effects of Mixed Micelles on the Morphological Integrity of the Nasal Mucosa | Parkpoom Tengamnuay and Ashim K. Mitra |
| 376-378 | 16α-Hydroxy-(–)-kauranoic Acid: A Selectively Cytotoxic Diterpene from Annona bullata | Yu-hua Hui, Ching-jer Chang, David L. Smith and Jerry L. McLaughlin |
| 379-383 | Drug-Excipient Incompatibility Studies of the Dipeptide Angiotensin-Converting Enzyme Inhibitor, Moexipril Hydrochloride: Dry Powder vs Wet Granulation | Leo Gu, Robert G. Strickley, Li-Hua Chi and Zak T. Chowhan |
| 384-387 | A Comparison of Oral and Rectal Absorption of L-Dopa Esters in Rats and Mice | Joseph A. Fix, Jose Alexander, Margot Cortese, Karen Engle and Paula Leppert, et al. |
| 388-391 | Isothermal and Nonisothermal Kinetics in the Stability Prediction of Vitamin A Preparations | Sumie Yoshioka, Yukio Aso and Yasushi Takeda |
| 392-397 | Intestinal Absorption of Drugs. III. The Influence of Taurocholate on the Disappearance Kinetics of Hydrophilic and Lipophilic Drugs from the Small Intestine of the Rat | Fred G. J. Poelma, Ria Breäs and Josef J. Tukker |
| 398-401 | Contribution of Monoamine Oxidase(MAO) to the Binding of Tertiary Basic Drugs in Isolated Perfused Rat Lung | Hisahiro Yoshida, Katsuhiko Okumura and Ryohei Hori |
| 402-406 | Stereochemical Characterization of the Diastereomers of the Phenobarbital N-β-D-Glucose Conjugate Excreted in Human Urine | William H. Soine, Phyllis J. Soine, Suzanne E. Mongrain and Terry M. England |
| 407-410 | Development of a Sensitive Activity Assay for High-Volume Evaluation of Human Renin Inhibitory Peptides in Rat Serum: Results with U-71,038 | Mary J. Ruwart, Satish K. Sharma, Douglas W. Harris, Duane B. Lakings and Bob D. Rush, et al. |
| 411-417 | Probenecid Inhibits the Metabolic and Renal Clearances of Zidovudine (AZT) in Human Volunteers | Mohsen A. Hedaya, William F. Elmquist and Ronald J. Sawchuk |
| 418-421 | Synthesis, Characterization, and in Vitro Stability of Chitosan-Methotrexate Conjugates | Yeshwant D. Sanzgiri, C. Dewitt Blanton and James M. Gallo |
| 422-424 | Evaluation of Free Tissue Concentrations of Fleroxacin After Oral Administration | Jobst Limberg, Marc LeBel and Hartmut Derendorf |
| 425-429 | On the Use of the Quasi-Equilibrium Assumption for Drug Dissolution | Sadettin S. Ozturk, Jennifer B. Dressman and Bernhard O. Palsson |
| 430 | BOOK REVIEWS |
| 431-432 | Letters to the Editor | Paolo Colombo, Ping I. Lee, Nikolaos A. Peppas and K. Padmalatha Devi |
| 433-434 | Editorial |
| 435-451 | The Use of Cultured Epithelial and Endothelial Cells for Drug Transport and Metabolism Studies | Kenneth L. Audus, Ronnda L. Bartel, Ismael J. Hidalgo and Ronald T. Borchardt |
| 452-460 | Chemical Stability of Pentostatin (NSC-218321), a Cytotoxic and Immunosuppressant Agent | Laman A. Al-Razzak, Annalisa E. Benedetti, Wanda N. Waugh and Valentine J. Stella |
| 461-467 | Nonlinear Binding of Valproic Acid (VPA) and E-Δ2-Valproic Acid to Rat Plasma Proteins | Robin L. O. Semmes and Danny D. Shen |
| 468-475 | The Effects of Permeation Enhancers on the Surface Morphology of the Rat Nasal Mucosa: A Scanning Electron Microscopy Study | Richard D. Ennis, Lucy Borden and William A. Lee |
| 476-483 | Ocular Pharmacokinetics and Pharmacodynamics of Phenylephrine and Phenylephrine Oxazolidine in Rabbit Eyes | Du-Shieng Chien and Ronald D. Schoenwald |
| 484-490 | Effect of Cyclodextrin Derivatives on Indomethacin Stability in Aqueous Solution | Thomas Backensfeld, Bernd W. Müller, Michael Wiese and Joachim K. Seydel |
| 491-495 | A Simple Rheological Method for the in Vitro Assessment of Mucin-Polymer Bioadhesive Bond Strength | Emad Eldin Hassan and James M. Gallo |
| 496-499 | Disposition and Metabolic Profiling of the Penetration Enhancer Azone. I. In Vivo Studies: Urinary Profiles of Hamster, Rat, Monkey, and Man | Johann W. Wiechers, Ben F. H. Drenth, Frank A. W. Adolfsen, Lia Prins and Rokus A. de Zeeuw |
| 500-503 | Nasal Absorption Enhancement of 17β-Estradiol by Dimethyl-β-Cyclodextrin in Rabbits and Rats | Walter A. J. J. Hermens, Marc J. M. Deurloo, Stefan G. Romeyn, J. Coos Verhoef and Frans W. H. M. Merkus |
| 504-507 | Quantification of Three Lidocaine Metabolites and Their Conjugates | Yun K. Tam, June Ke, Ronald T. Coutts, D. George Wyse and Murray R. Gray |
| 508-512 | The Liposome as a Model Membrane in Correlations of Partitioning with α-Adrenoceptor Agonist Activities | Young W. Choi and James A. Rogers |
| 513-517 | Dose-Dependent Pharmacokinetics of Carbamazepine in Rats: Determination of the Formation Clearance of Carbamazepine-10,11-epoxide | Rory P. Remmel, Michael W. Sinz and James C. Cloyd |
| 518-522 | Estimate of Volume/Flow Ratio of Gastrointestinal (GI) Fluids in Humans Using Pharmacokinetic Data | Panayotis Macheras, Christos Reppas and Jennifer B. Dressman |
| 523-529 | Solvent Interaction with Polydimethylsiloxane Membranes and Its Effects on Benzocaine Solubility and Diffusion | Karl M. Gelotte and Richard T. Lostritto |
| 530-536 | High-Performance Liquid Chromatographic (HPLC) and HPLC-Mass Spectrometric (MS) Analysis of the Degradation of the Luteinizing Hormone-Releasing Hormone (LH-RH) Antagonist RS-26306 in Aqueous Solution | Robert G. Strickley, Michael Brandl, Kelvin W. Chan, Kenneth Straub and Leo Gu |
| 537-541 | Drug Binding and Solubility in Milk | Panayotis E. Macheras, Michael A. Koupparis and Sophia G. Antimisiaris |
| 542-546 | Preparation of Asialofetuin-Labeled Liposomes with Encapsulated Human Interferon-γ and Their Uptake by Isolated Rat Hepatocytes | Hiroshi Ishihara, Toshifumi Hara, Yukihiko Aramaki, Seishi Tsuchiya and Kaoru Hosoi |
| 547-552 | The Effect of Sodium Tauro-24,25-Dihydrofusidate on the Nasal Absorption of Human Growth Hormone in Three Animal Models | Patricia A. Baldwin, Corine K. Klingbeil, Carla J. Grimm and John P. Longenecker |
| 553-557 | Adenosine Triphosphate Liposomes: Encapsulation and Distribution Studies | Xu Guo-Xing, Xie Xing-Hui, Liu Fang-Yu, Zang De-Liang and Zheng Dao-Sheng, et al. |
| 558-560 | Oral Bioavailability of Triamcinolone Tablets and a Triamcinolone Diacetate Suspension | Günther Hochhaus, Martin Pörtner, Jürgen Barth, Helmut Möllmann and Peter Rohdewald |
| 561 | A Better Way to Present Posters | Lewis J. Leeson and Gerhard Levy |
| 561-562 | BOOK REVIEWS |
| 562 | BOOK REVIEWS |
| 563 | BOOK REVIEWS |
| 563 | ADDENDUM |
| 564 | Association News and Announcements |
| 565-569 | Pulmonary Delivery of Peptide Drugs: Effect of Particle Size on Bioavailability of Leuprolide Acetate in Healthy Male Volunteers | Akwete Adjei and Julie Garren |
| 570-576 | Simultaneous Modeling of the Pharmacokinetic and Pharmacodynamic Properties of Benzodiazepines. II. Triazolam | Samir K. Gupta, Everett H. Ellinwood, Arlene M. Nikaido and Douglas G. Heatherly |
| 577-586 | Development of a Preformulation Lipophilicity Screen Utilizing a C-18-Derivatized Polystyrene-Divinylbenzene High-Performance Liquid Chromatographic (HPLC) Column | William J. Lambert and Latrelle A. Wright |
| 587-592 | Pharmacokinetics of a Mouse/Human Chimeric Monoclonal Antibody (C-17-1 A) in Metastatic Adenocarcinoma Patients | John M. Trang, Albert F. LoBuglio, Richard H. Wheeler, Elizabeth B. Harvey and Lee Sun, et al. |
| 593-599 | Chemical Pathways of Peptide Degradation. I. Deamidation of Adrenocorticotropic Hormone | Neelima P. Bhatt, Kamlesh Patel and Ronald T. Borchardt |
| 600-605 | Testing of Insulin Hexamer-Stabilizing Ligands Using Theoretical Binding, Microcalorimetry, and Nuclear Magnetic Resonance (NMR) Line Broadening Techniques | Scott E. McGraw, David J. Craik and Siegfried Lindenbaum |
| 606-611 | The Use of Microcalorimetry to Measure Thermodynamic Parameters of the Binding of Ligands to Insulin | Scott E. McGraw and Siegfried Lindenbaum |
| 612-615 | Pharmaceutical Usefulness of Hydroxypropylcyclodextrins: "E Pluribus Unum” Is an Essential Feature | C. Trinadha Rao, Henry M. Fales and Josef Pitha |
| 616-620 | Formulation and Dosage Form Design in Drug-Induced Topical Irritation of the Gastrointestinal Tract | John W. Fara and Robert E. Myrback |
| 621-627 | Oleic Acid: Its Effects on Stratum Corneum in Relation to (Trans)Dermal Drug Delivery | Michael L. Francoeur, Guia M. Golden and Russell O. Potts |
| 628-632 | Constant-Rate Intravenous Infusion Methods for Estimating Steady-State Volumes of Distribution and Mean Residence Times in the Body for Drugs Undergoing Reversible Metabolism | Haiyung Cheng and William J. Jusko |
| 633-637 | Binding of Drugs in Milk: The Role of Casein in Milk Protein Binding | Thomas Stebler and Theodor W. Guentert |
| 638-643 | Metabolic Conversion of Cyoctol During Skin Passage in Humans | Rokus A. de Zeeuw, Renella E. Herder, Johann W. Wiechers and Ben F. H. Drenth |
| 644-647 | Effect of Dextran Sulfate on Renal Accumulation of Gentamicin | Shinji Kikuchi, Yukihiko Aramaki, Homare Nonaka and Seishi Tsuchiya |
| 648-653 | The Effect of Physical Aging on the Dissolution Rate of Anionic Polyelectrolytes | Christopher M. Sinko, Albert F. Yee and Gordon L. Amidon |
| 654-657 | The Relationship Between the Glass Transition Temperature and Water Vapor Absorption by Poly(vinylpyrrolidone) | Cynthia A. Oksanen and George Zografi |
| 658-664 | Application of a Brain-Targeting Chemical Delivery System to 9-Amino-1,2,3,4-Tetrahydroacridine | Emil Pop, Katalin Prókai-Tátrai, James D. Scott, Marcus E. Brewster and Nicholas Bodor |
| 665-669 | Characterization of Epidermal Growth Factor Receptors on Plasma Membranes Isolated from Rat Gastric Mucosa | Ryohei Hori, Hisashi Nomura, Seigo Iwakawa and Katsuhiko Okumura |
| 670-672 | Effects of Amantadine on Dopaminergic Neurons in Discrete Regions of the Rat Brain | Katsuo Toide |
| 673-676 | Comparisons of in Vitro Nitroglycerin (TNG) Flux Across Yucatan Pig, Hairless Mouse, and Human Skins | Mary E. Roberts and Karl R. Mueller |
| 677-680 | Influence of Absorption Rate, Dosing Frequency, and Intrinsic Pharmacokinetic Profile on Steady-State Drug Concentrations | Michael A. Eldon and Wayne A. Colburn |
| 681 | BOOK REVIEWS |
| 682 | Association News and Announcements |
| 683-690 | Crystallographic Consequences of Molecular Dissymmetry | Harry G. Brittain |
| 691-696 | Relationships in the Structure–Tissue Distribution of Basic Drugs in the Rabbit | Koichi Yokogawa, Emi Nakashima, Junko Ishizaki, Hitoshi Maeda and Taizo Nagano, et al. |
| 697-702 | Optimization of the Therapeutic Index by Adjustment of the Rate of Drug Administration or Use of Drug Combinations: Exploratory Studies of Diuretics | Jianguo Zhi and Gerhard Levy |
| 703-711 | Chemical Pathways of Peptide Degradation. II. Kinetics of Deamidation of an Asparaginyl Residue in a Model Hexapeptide | Kamlesh Patel and Ronald T. Borchardt |
| 712-718 | Contributions of Drug Solubilization, Partitioning, Barrier Disruption, and Solvent Permeation to the Enhancement of Skin Permeation of Various Compounds with Fatty Acids and Amines | Bruce J. Aungst, Judy A. Blake and Munir A. Hussain |
| 719-722 | Sulfate Homeostasis. II. Influence of Chronic Aspirin Administration on Inorganic Sulfate in Humans | Marilyn E. Morris and Lisa Jo Benincosa |
| 723-725 | Site- and Stereospecific Ocular Drug Delivery by Sequential Enzymatic Bioactivation | Nicholas Bodor and Laszlo Prokai |
| 726-729 | Optical Purity Determination of threo-Methylphenidate Hydrochloride Using a Chiral Europium Nuclear Magnetic Resonance (NMR) Shift Reagent | George M. Hanna and Cesar A. Lau-Cam |
| 730-735 | Influence of Temperature and Hydrophobic Group-Associated Icebergs on the Activation Energy of Drug Decomposition and Its Implication in Drug Shelf-Life Prediction | Anil K. Kishore and Janardan B. Nagwekar |
| 736-741 | Vidarabine-Loaded Nanoparticles: A Physicochemical Study | Véronique Guise, Jehan-Yves Drouin, Jacqueline Benoit, Jacqueline Mahuteau and Pierre Dumont, et al. |
| 742-745 | The Metabolism of CGP-291: The Use of Microorganisms as Models of Mammalian Metabolism | Tannis M. Jürgens and Alice M. Clark |
| 746-750 | Quantitative Correlations and Reexamination of the Importance of Hydrophobic and Steric Factors in Anticholinergic Drug Receptor Interactions | Samitendu Banerjee and Eric J. Lien |
| 751-755 | Kinetics and Pattern of Degradation of Thyrotropin-Releasing Hormone (TRH) in Human Plasma | Judi Møss and Hans Bundgaard |
| 756-761 | Upper Gastrointestinal (GI) pH in Young, Healthy Men and Women | Jennifer B. Dressman, Rosemary R. Berardi, Lambros C. Dermentzoglou, Tanya L. Russell and Stephen P. Schmaltz, et al. |
| 762-766 | Percutaneous Absorption Enhancement of an Ionic Molecule by Ethanol–Water Systems in Human Skin | Tamie Kurihara-Bergstrom, Kristine Knutson, Linda J. DeNoble and Cynthia Y. Goates |
| 767-771 | Intestinal Transport of Sulfanilic Acid in Rats Immunized with Protein–Sulfanilic Acid Conjugate | A. Yamamoto, T. Kawaratani, K. Kawashima, M. Hashida and H. Sezaki |
| 772-776 | Nasal Absorption Enhancers for Biosynthetic Human Growth Hormone in Rats | Derek T. O'Hagan, Helen Critchley, Nidal F. Farraj, Anthony N. Fisher and Bente R. Johansen, et al. |
| 777-779 | Influence of Food on the Bioavailability of Ro 15-0778 in Humans | Alice A. Holazo, Evelyn E. Pinili, Francis T. De Grazia and Indravadan H. Patel |
| 780 | BOOK REVIEWS |
| 780 | BOOK REVIEWS |
| 780-781 | BOOK REVIEWS |
| 782-785 | Academic Pharmaceutics: The Challenge of Excellence | AAPS Task Force |
| 786 | Comment on “Academic Pharmaceutics: The Challenge of Excellence” | Wayne A. Colburn |
| 787-793 | Chemical Pathways of Peptide Degradation. III. Effect of Primary Sequence on the Pathways of Deamidation of Asparaginyl Residues in Hexapeptides | Kamlesh Patel and Ronald T. Borchardt |
| 794-800 | Stereochemical Characterization of the Diastereomers of the Amobarbital N-Glucosides Excreted in Human Urine | William H. Soine, Phyllis J. Soine, Fred C. Wireko and Donald J. Abraham |
| 801-807 | An Electrotopological-State Index for Atoms in Molecules | Lemont B. Kier and Lowell H. Hall |
| 808-815 | The Molecular Weight Dependence of Nasal Absorption: The Effect of Absorption Enhancers | Maureen D. Donovan, Gordon L. Flynn and Gordon L. Amidon |
| 816-823 | Biochemical and Mechanical Characterization of Enzyme-Digestible Hydrogels | Waleed S. W. Shalaby and Kinam Park |
| 824-834 | Efficiency of Cytoplasmic Delivery by pH-Sensitive Liposomes to Cells in Culture | Chun-Jung Chu, Jan Dijkstra, Ming-Zong Lai, Keelung Hong and Francis C. Szoka |
| 835-841 | Percutaneous Penetration Enhancement in Vivo Measured by Attenuated Total Reflectance Infrared Spectroscopy | Vivien H. W. Mak, Russell O. Potts and Richard H. Guy |
| 842-847 | Transdermal Delivery of Narcotic Analgesics: pH, Anatomical, and Subject Influences on Cutaneous Permeability of Fentanyl and Sufentanil | Samir D. Roy and Gordon L. Flynn |
| 848-851 | A Method for Quantifying Particle Absorption from the Small Intestine of the Mouse | James P. Ebel |
| 852-855 | Enhanced Intestinal Absorption of a Hydrophobic Polymer-Conjugated Protein Drug, Smancs, in an Oily Formulation | Kiichiro Oka, Yoichi Miyamoto, Yasuhiro Matsumura, Shohei Tanaka and Tatsuya Oda, et al. |
| 856-862 | Thermodynamics and Mathematical Modeling of the Partitioning of Chlorpromazine Between n-Octanol and Aqueous Buffer | Shiaw-Wen Cheng, Ravi Shanker and Siegfried Lindenbaum |
| 863-868 | Absorption of Polyethylene Glycols 600 Through 2000: The Molecular Weight Dependence of Gastrointestinal and Nasal Absorption | Maureen D. Donovan, Gordon L. Flynn and Gordon L. Amidon |
| 869-873 | Beta-Cyclodextrin/Steroid Complexation: Effect of Steroid Structure on Association Equilibria | Fang-yu Liu, Dane O. Kildsig and Ashim K. Mitra |
| 874-878 | Performance of Diltiazem Tablet and Multiparticulate Osmotic Formulations in the Dog | Steven C. Sutton, Karen Engle, Rodney A. Deeken, Kathleen E. Plute and Richard D. Shaffer |
| 879-883 | A Redox-Based System that Enhances Delivery of Estradiol to the Brain: Pharmacokinetic Evaluation in the Dog | Klaus Dietzel, Volker Keuth, Kerry S. Estes, Marcus E. Brewster and Roger M. Clemmons, et al. |
| 884 | BOOK REVIEWS |
| 884 | BOOK REVIEWS |
| 885-892 | Prodrugs of Peptides. 6. Bioreversible Derivatives of Thyrotropin-Releasing Hormone (TRH) with Increased Lipophilicity and Resistance to Cleavage by the TRH-Specific Serum Enzyme | Hans Bundgaard and Judi Møss |
| 893-901 | Diffusion in Porous Materials Above the Percolation Threshold | Jayne E. Hastedt and James L. Wright |
| 902-910 | Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal Mucosa | Allen R. Hilgers, Robert A. Conradi and Philip S. Burton |
| 911-918 | Determination of Solute–Polymer Interaction Properties and Their Application to Parenteral Product Container Compatibility Evaluations | Richard A. Kenley and Dennis R. Jenke |
| 919-922 | Synthesis and Calcium Channel Antagonist Activity of 3-Arylmethyl 5-Isopropyl l,4-Dihydro-2,6-dimethyl-4-(pyridyl)-3,5-pyridinedicarboxylates | Murthy R. Akula, Wandikayi C. Matowe, Michael W. Wolowyk and Edward E. Knaus |
| 923-927 | Structure Elucidation and Thermospray High-Performance Liquid Chromatography/Mass Spectroscopy (HPLC/MS) of the Microbial and Mammalian Metabolites of the Antimalarial Arteether | Charles D. Hufford, Ik-Soo Lee, Hala N. ElSohly, Hsien Tao Chi and John K. Baker |
| 928-934 | Influence of Average Molecular Weights of Poly(DL-Lactic Acid-Co-Glycolic Acid) Copolymers 50/50 on Phase Separation and in Vitro Drug Release from Microspheres | Jean-Marc Ruiz, Jean-Pierre Busnel and Jean-Pierre Benoît |
| 935-941 | Physicochemical Factors Associated with Binding and Retention of Compounds in Ocular Melanin of Rats: Correlations Using Data from Whole-Body Autoradiography and Molecular Modeling for Multiple Linear Regression Analyses | Patricia A. Zane, Shirley D. Brindle, Douglas O. Gause, Arlene J. O'Buck and Palayakotai R. Raghavan, et al. |
| 942-947 | Melting Point, Boiling Point, and Symmetry | Robert Abramowitz and Samuel H. Yalkowsky |
| 948-952 | Enhanced Delivery of Zidovudine Through Rat and Human Skin via Ester Prodrugs | Toshinobu Seki, Takeo Kawaguchi and Kazuhiko Juni |
| 953-956 | Comparison of Single-Dose and Steady-State Nadolol Plasma Concentrations | Julie J. Krukemyer, Harisios Boudoulas, Philip F. Binkley and John J. Lima |
| 957-961 | Solubilization of Liposomes by Weak Electrolyte Drugs. I. Propranolol | James A. Rogers, Gurupadappa V. Betageri and Young W. Choi |
| 962-966 | Particle Size and Content Uniformity | Samuel H. Yalkowsky and Sanford Bolton |
| 967-972 | Influence of Solute Degradation on the Accumulation of Solutes Migrating into Solution from Polymeric Parenteral Containers | Lawrence A. Cruz, Mai P. Jenke, Richard A. Kenley, Ming J. Chen and Dennis R. Jenke |
| 973 | BOOK REVIEWS |
| 973 | BOOK REVIEWS |
| 973 | BOOK REVIEWS |
| 974 | ERRATUM |
| 975-982 | In Vitro and in Vivo Testing and Correlation for Oral Controlled/Modified-Release Dosage Forms | Jerome P. Skelly, Gordon L. Amidon, William H. Barr, Leslie Z. Benet and James E. Carter, et al. |
| 983-987 | The Development of USP Dissolution and Drug Release Standards | Jordan L. Cohen, Barbara B. Hubert, Lewis J. Leeson, Christopher T. Rhodes and Joseph R. Robinson, et al. |
| 988-989 | Treating Seriously Ill Patients with Experimental Drugs | Francis B. Palumbo |
| 990-994 | Solute Absorption from the Airways of the Isolated Rat Lung. III. Absorption of Several Peptidase-Resistant, Synthetic Polypeptides: Poly-(2-Hydroxyethyl)-Aspartamides | Ralph W. Niven, Frantisek Rypacek and Peter R. Byron |
| 995-1002 | In Vitro Skin Permeation and Bioassay of Chlorhexidine Phosphanilate, a New Antimicrobial Agent | Jonas C. T. Wang, Robert R. Williams, Lotte Wang and John Loder |
| 1003-1010 | Mean Interconversion Times and Distribution Rate Parameters for Drugs Undergoing Reversible Metabolism | Haiyung Cheng and William J. Jusko |
| 1011-1018 | Growth Hormone (GH) Secretory Dynamics in Animals Administered Estradiol Utilizing a Chemical Delivery System | William J. Millard, Teresa M. Romano, Nicholas Bodor and James W. Simpkins |
| 1019-1025 | Phosphatidylserine as a Determinant for the Tissue Distribution of Weakly Basic Drugs in Rats | Noboru Yata, Toshihiko Toyoda, Teruo Murakami, Akio Nishiura and Yutaka Higashi |
| 1026-1032 | Application of Radiotelemetric Technique in Evaluating Diclofenac Sodium Absorption After Oral Administration of Various Dosage Forms in Healthy Volunteers | Keith K. H. Chan, Parviz Mojaverian, Barbara A. Ziehmer and Vivian A. John |
| 1033-1037 | Evaluation of a Noninvasive Method for Monitoring Percutaneous Absorption of Lidocaine in Vivo | Gregory P. Kushla and Joel L. Zatz |
| 1038-1041 | Analysis of Hepatic Transport of Cefpiramide in Rats with Obstructive Jaundice by Using Isolated Hepatocytes | Tadanao Yamao, Seiya Nakayama, Yuji Kurosaki, Taiji Nakayama and Toshikiro Kimura |
| 1042-1047 | Use of Shed Snake Skin as a Model Membrane for in Vitro Percutaneous Penetration Studies: Comparison with Human Skin | Tomoo Itoh, Jun Xia, Ravi Magavi, Toshiaki Nishihata and J. Howard Rytting |
| 1048-1054 | Topical Drug Delivery from Thin Applications: Theoretical Predictions and Experimental Results | William Addicks, Norman Weiner, Gordon Flynn, Rane Curl and Elizabeth Topp |
| 1055-1060 | Binding of Pyrimethamine to Human Plasma Proteins and Erythrocytes | Anita C. Rudy and Wesley J. Poynor |
| 1061-1067 | Dose and Time-Course Evaluation of a Redox-Based Estradiol-Chemical Delivery System for the Brain. I. Tissue Distribution | Mohamad H. Rahimy, James W. Simpkins and Nicholas Bodor |
| 1068-1070 | A Method for Determination of the Absolute Pulmonary Bioavailability of Inhaled Drugs: Terbutaline | Lars Borgström and Marita Nilsson |
| 1071-1076 | Pharmacokinetic Screening of o-Naphthoquinone 5-Lipoxygenase Inhibitors | Ashok Rakhit, Steve K. Kuwahara, David R. Jones, Victor F. Soliman and Alvin N. Kotake, et al. |
| 1077-1081 | Microdialysis Sampling for Determination of Plasma Protein Binding of Drugs | Ada M. Herrera, Dennis O. Scott and Craig E. Lunte |
| 1082-1085 | Ultraviolet (UV) Absorption and Circular Dichroism (CD) Spectra of Captopril | Harry G. Brittain and Harold Kadin |
| 1086-1091 | The Effects of Formulation Additives on the Degradation of Freeze-Dried Ribonuclease A | Michael W. Townsend, Peter R. Byron and Patrick P. DeLuca |
| 1092-1097 | A Statistical Approach for the Development of an Oral Controlled-Release Matrix Tablet | Alton D. Johnson, Virgil L. Anderson and Garnet E. Peck |
| 1098 | Association News and Announcements |
| 1099-1106 | Transdermal Delivery of Bioactive Peptides: The Effect of n-Decylmethyl Sulfoxide, pH, and Inhibitors on Enkephalin Metabolism and Transport | Hoo-Kyun Choi, Gordon L. Flynn and Gordon L. Amidon |
| 1107-1112 | Dose and Time-Course Evaluation of a Redox-Based Estradiol-Chemical Delivery System for the Brain. II. Pharmacodynamic Responses | Mohamad H. Rahimy, James W. Simpkins and Nicholas Bodor |
| 1113-1118 | A Sensitive and Specific Liquid-Chromatographic Assay for Determination of Ganciclovir in Plasma and Urine and Its Application to Pharmacokinetic Studies in the Rabbit | Mohsen A. Hedaya and Ronald J. Sawchuk |
| 1119-1126 | Characterization of a Hot-Melt Fluid Bed Coating Process for Fine Granules | Michael J. Jozwiakowski, David M. Jones and Robert M. Franz |
| 1127-1133 | Nebulization of Liposomes. I. Effects of Lipid Composition | Ralph W. Niven and Hans Schreier |
| 1134-1140 | Theophylline-Controlled Release Preparations and Fatty Food: An in Vitro Study Using the Rotating Dialysis Cell Method | Silvia K. El-Arini, Gerald K. Shiu and Jerome P. Skelly |
| 1141-1146 | Electrical Analysis of Fresh, Excised Human Skin: A Comparison with Frozen Skin | Gerald B. Kasting and Lisa A. Bowman |
| 1147-1151 | In Vitro Skin Absorption and Metabolism of Benzoic Acid, p-Aminobenzoic Acid, and Benzocaine in the Hairless Guinea Pig | David Nathan, Adel Sakr, J. Leon Lichtin and Robert L. Bronaugh |
| 1152-1156 | Enhancement of the Antiinflammatory Effect of Ethyl 4-Biphenylyl Acetate in Ointment by β-Cyclodextrin Derivatives: Increased Absorption and Localized Activation of the Prodrug in Rats | Hidetoshi Arima, Hirotoshi Adachi, Tetsumi Irie, Kaneto Uekama and Josef Pitha |
| 1157-1162 | Solid and Liquid Heat Capacities of n-Alkyl Para-aminobenzoates Near the Melting Point | Steven H. Neau and Gordon L. Flynn |
| 1163-1166 | Gastrointestinal Transit of Nondisintegrating, Nonerodible Oral Dosage Forms in Pigs | Mohammad Hossain, Wattanaporn Abramowitz, Barbara J. Watrous, Gregory J. Szpunar and James W. Ayres |
| 1167-1171 | Release and Absorption Characteristics of Novel Theophylline Sustained-Release Formulations: In Vitro-in Vivo Correlation | Ziad Hussein and Michael Friedman |
| 1172-1176 | Evaluation of the Pharmacokinetic Interaction Between Diazepam and ACC-9653 (a Phenytoin Prodrug) in Healthy Male Volunteers | Elizabeth K. Hussey, George E. Dukes, John A. Messenheimer, Kim L. R. Brouwer and Karl H. Donn, et al. |
| 1177-1180 | Determination of Temafloxacin, Sarafloxacin, and Difloxacin in Bulk Drug and Dosage Forms by High-Performance Liquid Chromatography | John F. Bauer, Lee Elrod, Jr., Joseph R. Fornnarino, Douglas E. Heathcote and Sue K. Krogh, et al. |
| 1181-1185 | Physical State of Misoprostol in Hydroxypropyl Methylcellulose Films | Tugrul T. Kararli, Thomas E. Needham, Cliff J. Seul, Pat M. Finnegan and Marianne I. Hidvegi, et al. |
| 1186-1189 | Stabilization of Misoprostol with Hydroxypropyl Methylcellulose (HPMC) Against Degradation by Water | Tugrul T. Kararli and Thomas Catalano |
| 1190-1194 | Release of Human Serum Albumin from Poly(lactide-co-glycolide) Microspheres | Maninder S. Hora, Rajsharan K. Rana, Jack H. Nunberg, Thomas R. Tice and Richard M. Gilley, et al. |
| 1195-1197 | A Flat Circular Hole Device for Zero-Order Release of Drugs: Characterization of the Moving Dissolution Boundary | Dinesh S. Mishra and Samuel H. Yalkowsky |
| 1198-1200 | Scintigraphic Evaluation of the Ocular Disposition of 18F-Imirestat in Rabbits | Ganesan Vaidyanathan, Michael Jay, Ranajit K. Bera, Philip R. Mayer and R. K. Brazzell |
| 1201-1204 | Epidermal Differentiation and Permeability in Fetal Pig Skin | Tamie Kurihara-Bergstrom, William R. Good, Carol Signer and Marguerite Woodworth |
| 1205-1207 | Morphine Impurity with Opioid Activity Is Identified as 10α-Hydroxymorphine | Hassan Farsam, Steven Eiger, Jelveh Lameh, Ahmad Rezvani and Bradford W. Gibson, et al. |
| 1208-1209 | Effects of a Diluent on the Retarded–Release Property of Acrylate Methacrylate–Salicylic Acid Coacervates | R. S. Okor and M. A. Yahaya |
| 1210 | BOOK REVIEWS |
| 1210 | BOOK REVIEWS |
| 1211 | BOOK REVIEWS |
| 1212 | Association News and Announcements |
| 1213-1221 | Structure and Function of G Protein Coupled Receptors | Jelveh Lameh, Ric I. Cone, Sadaaki Maeda, Mohan Philip and Maithe Corbani, et al. |
| 1222-1227 | Pharmacokinetics of a Single Intravenous and Oral Dose of Pafenolol—a Beta1Adrenoceptor Antagonist with Atypical Absorption and Disposition Properties—in Man | Carl G. Regårdh, Per Lundborg, Margareth Gabrielsson, Asger Heggelund and Kerstin Kylberg-Hanssen |
| 1228-1233 | Optimized Inhalation Aerosols. II. Inertial Testing Methods for Particle Size Analysis of Pressurized Inhalers | Elaine M. Phillips, Peter R. Byron, Kristen Fults and Anthony J. Hickey |
| 1234-1241 | Analytical Approaches to the Study of Monoclonal Antibody Stability | Wim Jiskoot, E. Coen Beuvery, Ada A. M. de Koning, James N. Herron and Daan J. A. Crommelin |
| 1242-1247 | An Experimental Model for Measuring Middle Ear Antimicrobial Drug Penetration in Otitis Media | Gregg H. Jossart, Gary R. Erdmann, David G. Levitt, Peter Kucera and Chap T. Le, et al. |
| 1248-1252 | The Pharmacokinetics of β-Cyclodextrin and Hydroxypropyl-β-cyclodextrin in the Rat | Henderik W. Frijlink, Jan Visser, Nanco R. Hefting, Roelof Oosting and Dirk K. F. Meijer, et al. |
| 1253-1256 | Stability of Gonadorelin and Triptorelin in Aqueous Solution | Volker J. Helm and Bernd W. Müller |
| 1257-1261 | Column-Switching High-Performance Liquid Chromatographic (HPLC) Determination of Hydrochlorothiazide in Rat, Dog, and Human Plasma | Be-Sheng Kuo, Arun Mandagere, David R. Osborne and Kin-Kai Hwang |
| 1262-1268 | Chiral Amines Derived from 2-Arylpropionic Acids: Novel Reagents for the Liquid Chromatographic (LC) Fluorescence Assay of Optically Active Carboxylic Acid Xenobiotics | Hildegard Spahn and Peter Langguth |
| 1269-1272 | Sesquiterpene Lactones and Other Constituents from a Cytotoxic Extract of Michelia floribunda | Ing-On Mondranondra, Chun-tao Che, Agnes M. Rimando, Srunya Vajrodaya and Harry H. S. Fong, et al. |
| 1273-1277 | Heat Sterilization of Bioindicators in Propylene Glycol and Propylene Glycol–Water Mixtures: Arrhenius Equation, Thermodynamic Data, and Z Values | Brigitte Philipp and Heinz Sucker |
| 1278-1281 | Amorphous-to-Crystalline Transformation of Sucrose | Jens T. Carstensen and Kurt Van Scoik |
| 1282-1288 | Aluminum Compounds Used as Adjuvants in Vaccines | Suhag Shirodkar, Robert L. Hutchinson, Darold L. Perry, Joe L. White and Stanley L. Hem |
| 1289-1293 | Improvement in Wound Healing by Epidermal Growth Factor (EGF) Ointment. I. Effect of Nafamostat, Gabexate, or Gelatin on Stabilization and Efficacy of EGF | Katsuhiko Okumura, Yoshifumi Kiyohara, Fusao Komada, Seigo Iwakawa and Midori Hirai, et al. |
| 1294-1297 | Cytotoxicity of Three Novel Fluoropyrimidines in Cultured L1210 Murine Lymphocytic Leukemia Cells | Annette M. Shipp, Mark H. Holshouser and Paul W. Ferguson |
| 1298-1301 | Cutaneous Pharmacodynamics of Transdermally Delivered Isosorbide Dinitrate | Mitsuhiko Hori, Saburoh Ohtsuka, Masaki Sunami, Richard H. Guy and Howard I. Maibach |
| 1302-1306 | A Method to Predict the Percutaneous Permeability of Various Compounds: Shed Snake Skin as a Model Membrane | Tomoo Itoh, Ravi Magavi, Roger L. Casady, Toshiaki Nishihata and J. Howard Rytting |
| 1307-1312 | Investigations on the Percutaneous Absorption of the Antidepressant Rolipram in Vitro and in Vivo | Jonathan Hadgraft, Stephanie Hill, Michael Hümpel, Linda R. Johnston and Lawrence R. Lever, et al. |
| 1313-1319 | Mechanism of L-α-Methyldopa Transport Through a Monolayer of Polarized Human Intestinal Epithelial Cells (Caco-2) | Ming Hu and Ronald T. Borchardt |
| 1320-1324 | Optimization of Topical Therapy: Partitioning of Drugs into Stratum Corneum | Christian Surber, Klaus-P. Wilhelm, Mitsuhiko Hori, Howard I. Maibach and Richard H. Guy |
| 1325-1328 | Solubility and lonization Behavior of the Antiarrhythmic 4-hydroxy-N-phenyl-3,5-bis(l-pyrrolidinylmethyl)benzamide dihydrochloride (DuP 923) | Michael B. Maurin, George Dowuona-Owoo and George Torosian |
| 1329 | BOOK REVIEWS |
| 1329-1330 | BOOK REVIEWS |
| 1330 | BOOK REVIEWS |
| 1330-1331 | BOOK REVIEWS |
| 1331 | Letters to the Editor | Klaus G. Florey, John W. Fara and Robert E. Myrback |
| 1332-1333 | Reviewers for Pharmaceutical Research (October 1989-October 1990) |
| 1334-1336 | Author Index to Volume 7 (1990) |
| 1337-1345 | Subject Index to Volume 1 (1990) |
| 1346 | Association News and Announcements |
| 1-8 | Development of Delta Opioid Peptides as Nonaddicting Analgesics | Rao S. Rapaka and Frank Porreca |
| 9-16 | The Effect of Parenterally Administered Cyclodextrins on Cholesterol Levels in the Rat | Henderik W. Frijlink, Anko C. Eissens, Nanco R. Hefting, Klaas Poelstra and Coenraad F. Lerk, et al. |
| 17-24 | Terpenes and the Lipid–Protein–Partitioning Theory of Skin Penetration Enhancement | Adrian C. Williams and Brian W. Barry |
| 25-32 | The Role of Metabolites in Bioequivalency Assessment. I. Linear Pharmacokinetics without First-Pass Effect | Mei-Ling Chen and André J. Jackson |
| 33-39 | Quantification of Imipenem’s Primary Metabolite in Plasma by Postcolumn Chemical Rearrangement and UV Detection | Donald G. Musson, Richard Hajdu, William F. Bayne and John D. Rogers |
| 40-42 | Absorption and Disposition of Colloidal Drug Delivery Systems. I. High-Performance Liquid Chromatographic (HPLC) Analysis of a Cyclosporin Emulsion | Susan J. Corvari, R. Gary Hollenbeck, James Leslie, Karen I. Plaisance and David Young |
| 43-46 | Quantitative Structure–Activity Relationships (QSARs) of Pyrimidine Nucleosides as HIV-1 Antiviral Agents | Massoud Mahmoudian |
| 47-54 | Optimization of Spray-Dried and -Congealed Lipid Micropellets and Characterization of Their Surface Morphology by Scanning Electron Microscopy | Türkan Eldem, Peter Speiser and Atilla Hincal |
| 55-59 | In Vitro Release of Hydrocortisone from Topical Preparations and Automated Procedure | Vinod P. Shah, Jerome Elkins, James Hanus, Carol Noorizadeh and Jerome P. Skelly |
| 60-64 | Enhanced Bioavailability of Subcutaneously Injected Insulin by Pretreatment with Ointment Containing Protease Inhibitors | Masaharu Takeyama, Toshihiko Ishida, Noriko Kokubu, Fusao Komada and Seigo Iwakawa, et al. |
| 65-69 | Role of Complements C3 and C5 in the Phagocytosis of Liposomes by Human Neutrophils | Jeffrey F. Scieszka, Linda L. Maggiora, Samuel D. Wright and M. J. Cho |
| 70-75 | A Comparison of Peptidase Activities and Peptide Metabolism in Cultured Mouse Keratinocytes and Neonatal Mouse Epidermis | Praful K. Shah and Ronald T. Borchardt |
| 76-79 | Studies in Phlebitis: Detection and Quantitation Using a Thermographic Camera | Gary H. Ward, Paul E. Nolan, Monica Chawla and Samuel H. Yalkowsky |
| 80-83 | Precipitation of the Renin Inhibitor Ditekiren Upon iv Infusion; in Vitro Studies and Their Relationship to in Vivo Precipitation in the Cynomolgus Monkey | Stephen R. Davio, Margaret M. McShane, Thomas J. Kakuk, Renee M. Zaya and Serena L. Cole |
| 84-87 | Relationship Between Drug Absorption Enhancing Activity and Membrane Perturbing Effects of Acylcarnitines | Edward L. LeCluyse, Leah E. Appel and Steven C. Sutton |
| 88-92 | The Solubility-Modulated Osmotic Pump: In Vitro/in Vivo Release of Diltiazem Hydrochloride | Gregory A. McClelland, Steven C. Sutton, Karen Engle and Gaylen M. Zentner |
| 93-96 | Oral Absorption of Peptides: Influence of pH and Inhibitors on the Intestinal Hydrolysis of Leu-Enkephalin and Analogues | Doron I. Friedman and Gordon L. Amidon |
| 97-100 | Mechanism of Gastric Emptying of a Nondisintegrating Radiotelemetry Capsule in Man | Parviz Mojaverian, James C. Reynolds, Ann Ouyang, Fern Wirth and Paul E. Kellner, et al. |
| 101-105 | Jejunal Absorption, Pharmacological Activity, and Pharmacokinetic Evaluation of Indomethacin-Loaded Poly(d,l-Lactide) and Poly(Isobutyl-Cyanoacrylate) Nanocapsules in Rats | Nazih Ammoury, Hatem Fessi, Jean-Philippe Devissaguet, Marcelle Dubrasquet and Simon Benita |
| 106-111 | Thermal Injury Decreases Hepatic Blood Flow and the Intrinsic Clearance of Indocyanine Green in the Rat | Gary M. Pollack and Kim L. R. Brouwer |
| 112-118 | Dose-Dependent Pharmacokinetics of the Aldose Reductase Inhibitor Imirestat in Man | R. Kim Brazzell, Philip R. Mayer, Richard Dobbs, Patrick J. McNamara and Renli Teng, et al. |
| 119-122 | Structural Confirmation of Ampicillin Polymers Formed in Aqueous Solution | Hatsumi Aki, Nobuyoshi Sawai, Kenji Yamamoto and Magobei Yamamoto |
| 123-126 | Examination of Arrhenius Kinetics for an Antiarrhythmic Compound | Tugrul T. Kararli, Thomas Catalano and Richard M. Bittman |
| 127-130 | The Effects Of Hemodilution, pH, and Protamine on Lidocaine Plasma Protein Binding and Red Blood-Cell Uptake in Vitro | Rory P. Remmel, Alan K. Copa and David M. Angaran |
| 131-133 | Self-Release of Lipase from Compacts Materials | M. Hossein Zarrintan and Michael J. Groves |
| 134-135 | Intranasal Delivery of RS-93522, a Dihydropyridine-Type Calcium-Channel Antagonist | Roger Cherng-Chi Fu, John L. Whatley and Jeffrey S. Fleitman |
| 136-138 | Consensus Report on "Issues in the Evaluation of Bioavailability" | Iain J. McGilveray |
| 139 | Editorial |
| 140 | Reviewers for Pharmaceutical Research (November 1989-November 1990) |
| 141-147 | Mass Receptor Screening for New Drugs | Ronald M. Burch and Donald J. Kyle |
| 148-155 | Solid-State Phase Transitions Initiated by Water Vapor Sorption of Crystalline L-660,711, a Leukotriene D4 Receptor Antagonist | Elizabeth B. Vadas, Pascal Toma and George Zografi |
| 156-161 | Design and Manufacture of a Zero-Order Sustained-Release Pellet Dosage Form Through Nonuniform Drug Distribution in a Diffusional Matrix | Douglas C. Scott and R. Gary Hollenbeck |
| 162-167 | Extent and Variability of the First-Pass Elimination of Adinazolam Mesylate in Healthy Male Volunteers | Joseph C. Fleishaker, H. Friedman and Steven R. Pollock |
| 168-173 | A Method to Study Drug Concentration–Depth Profiles in Tissues: Mitomycin C in Dog Bladder Wall | M. Guillaume Wientjes, James T. Dalton, Robert A. Badalament, Bharat M. Dasani and Joseph R. Drago, et al. |
| 174-177 | Synthesis and in Vitro Receptor Binding Studies of Fluorotamoxifen Analogues | David J. Yang, Sidney Wallace, Wayne Tansey, Kenneth C. Wright and Li-Ren Kuang, et al. |
| 178-184 | Polymorphic Behavior of Sprayed Lipid Micropellets and Its Evaluation by Differential Scanning Calorimetry and Scanning Electron Microscopy | Türkan Eldem, Peter Speiser and Hans Altorfer |
| 185-190 | In Vitro Release Profile of Mitomycin C from Albumin Microspheres: Extrapolation from Macrospheres to Microspheres | Hideshi Natsume, Kenji Sugibayashi and Yasunori Morimoto |
| 191-195 | Water Vapor Adsorption and Desorption Isotherms of Biologically Active Proteins | C. Diana Teng, M. Hossein Zarrintan and Michael J. Groves |
| 196-199 | Opioid-Induced Respiratory Depression and Analgesia May Be Mediated by Different Subreceptors | Enno Freye, Martina Schnitzler and Gustav Schenk |
| 200-203 | High-Affinity [3H]THA (Tetrahydroaminoacridine) Binding Sites in Rat Brain | E. Edward Mena and Manoj C. Desai |
| 204-209 | Influence of Ultrasound on the Percutaneous Absorption of Nicotinate Esters | Heather A. E. Benson, James C. McElnay, Robin Harland and Jonathan Hadgraft |
| 210-216 | A Model of Human Small Intestinal Absorptive Cells. 1. Transport Barrier | J. Nita Cogburn, Matthew G. Donovan and Charles S. Schasteen |
| 217-221 | Nebulization of Liposomes. II. The Effects of Size and Modeling of Solute Release Profiles | Ralph W. Niven, Melissa Speer and Hans Schreier |
| 222-227 | Characterization of the Unstirred Water Layer in Caco-2 Cell Monolayers Using a Novel Diffusion Apparatus | Ismael J. Hidalgo, Kathleen M. Hillgren, George M. Grass and Ronald T. Borchardt |
| 228-231 | Model Selection for the Adsorption of Phenobarbital by Activated Charcoal | Gerald M. Burke, Dale Eric Wurster, Varaporn Buraphacheep, Mary J. Berg and Peter Veng-Pedersen, et al. |
| 232-237 | Computer-Aided Dosage Form Design. III. Feasibility Assessment for an Oral Prolonged-Release Phenytoin Product | Joy R. Irvin and Robert E. Notari |
| 238-241 | Effect of Competing Anions on Binding of Bile Salts by Cholestyramine | Rosemary Kos, Joe L. White, Stanley L. Hem and Marie T. Borin |
| 242-246 | Sulfate Homeostasis. III. Effect of Chronic Naproxen or Sulindac Treatment on Inorganic Sulfate Disposition in Arthritic Patients with Renal Impairment | Marilyn E. Morris, Jack P. Freer and William A. Watson |
| 247-253 | Hybrid Pharmacokinetic Models to Describe Anti-HIV Nucleoside Brain Disposition Following Parent and Prodrug Administration in Mice | James M. Gallo, Joseph T. Etse, Kokila J. Doshi, F. Douglas Boudinot and Chung K. Chu |
| 254-258 | Simple Methods for Estimation of Mean Residence Time and Steady-State Volume of Distribution from Continuous-Infusion Data | William R. Gillespie |
| 259-262 | Stereoselective Transport of Baclofen Across the Blood–Brain Barrier in Rats as Determined by the Unit Impulse Response Methodology | Joost B. M. M. van Bree, Corrie D. Heijligers-Feijen, Albertus G. de Boer, Meindert Danhof and Douwe D. Breimer |
| 263-268 | Pharmacodynamics of Methylprednisolone Phosphate After Single Intravenous Administration to Healthy Volunteers | Hartmut Derendorf, Helmut Möllmann, Michael Krieg, Sabine Tunn and Carsten Möllmann, et al. |
| 269-272 | Simplified Determination of Antipyrine Clearance by Liquid Chromatography of a Microsample of Saliva or Plasma | Adnan El-Yazigi, Dale A. Raines, Hatim Ali, Jens Sieck and Peter Ernst, et al. |
| 273-277 | Protection Against Microcystin-LR-Induced Hepatotoxicity by Silymarin: Biochemistry, Histopathology, and Lethality | Kay A. Mereish, David L. Bunner, Danny R. Ragland and Donald A. Creasia |
| 278-281 | Prediction of Acute Graft Rejection in Renal Transplantation: The Utility of Cyclosporine Blood Concentrations | Joachim Grevel, Kimberly L. Napoli, Maria S. Welsh, Neely E. Atkinson and Barry D. Kahan |
| 282-284 | The Relationship Between Urine and Plasma Concentrations of Carbamazepine: Implications for Therapeutic Drug Monitoring | William F. Elmquist, Lillian E. Riad, Ilo E. Leppik and Ronald J. Sawchuk |
| 285-291 | Protein–Solvent Interactions in Pharmaceutical Formulations | Tsutomu Arakawa, Yoshiko Kita and John F. Carpenter |
| 292-297 | Preformulation Studies Involving Moisture Uptake in Solid Dosage Forms | Dorothy R. Heidemann and Paul J. Jarosz |
| 298-305 | Calculation of the Aqueous Diffusion Layer Resistance for Absorption in a Tube: Application to Intestinal Membrane Permeability Determination | Jim H. Kou, David Fleisher and Gordon L. Amidon |
| 306-312 | Relationship of Apparent Systemic Clearance to Individual Organ Clearances: Effect of Pulmonary Clearance and Site of Drug Administration and Measurement | Reza Mehvar |
| 313-322 | Prodrugs of Peptides. 9. Bioreversible N-α-Hydroxyalkylation of the Peptide Bond to Effect Protection Against Carboxypeptidase or Other Proteolytic Enzymes | Hans Bundgaard and GitteJuel Rasmussen |
| 323-330 | Amine Prodrugs Which Utilize Hydroxy Amide Lactonization. I. A Potential Redox-Sensitive Amide Prodrug | Kent L. Amsberry and Ronald T. Borchardt |
| 331-335 | Bead Coating. I. Change in Release Kinetics (and Mechanism) Due to Coating Levels | Guohua Zhang, Joseph B. Schwartz and Roger L. Schnaare |
| 336-340 | Effect of Moisture Content on Compression Properties of Two Dextrose-Based Directly Compressible Diluents | Atul J. Shukla and James C. Price |
| 341-344 | Production of 5–15 µm Diameter Alginate-Polylysine Microcapsules by an Air-Atomization Technique | K.Keith Kwok, Michael J. Groves and Diane J. Burgess |
| 345-349 | Thermorheologic Properties of Aqueous Solutions and Gels of Tetronic 1508 | Christopher W. Spancake, Dane O. Kildsig and Ashim K. Mitra |
| 350-354 | Evidence that Oleic Acid Exists in a Separate Phase Within Stratum Corneum Lipids | Boonsri Ongpipattanakul, Ronald R. Burnette, Russell O. Potts and Michael L. Francoeur |
| 355-359 | Constant Potassium Chloride Release from Microporous Membrane-Coated Tablets Prepared with Aqueous Colloidal Polymer Dispersions | Roland Bodmeier and Ornlaksana Paeratakul |
| 360-364 | Variation in Gastrointestinal Transit of Pharmaceutical Dosage Forms in Healthy Subjects | Alastair J. Coupe, Stanley S. Davis and Ian R. Wilding |
| 365-369 | Study of the Mechanisms of Flux Enhancement Through Hairless Mouse Skin by Pulsed DC Iontophoresis | Michael J. Pikal and Saroj Shah |
| 370-375 | Sites of First-Pass Bioactivation (Hydrolysis) of Orally Administered Zofenopril Calcium in Dogs | Richard A. Morrison, Dennis E. Burkett, Mark E. Arnold, Celia J. D'Arienzo and Stephen H. Weinstein |
| 376-379 | Sulfate Homeostasis. IV. Probenecid-Induced Alterations of Inorganic Sulfate in Rats | Inger M. Darling and Marilyn E. Morris |
| 380-384 | The Effects of Cyclodextrins on the Disposition of Intravenously Injected Drugs in the Rat | Henderik W. Frijlink, Eric J. F. Franssen, Anko C. Eissens, Roelof Oosting and Coenraad F. Lerk, et al. |
| 385-388 | Pharmacokinetics of Multiple Daily Transdermal Doses of Nicotine in Healthy Smokers | Holly D. Ross, Keith K. H. Chan, Anthony J. Piraino and Vivian A. John |
| 389-392 | In Vivo Microdialysis Sampling for Pharmacokinetic Investigations | Dennis O. Scott, Lori R. Sorenson, Karla L. Steele, DeAnna L. Puckett and Craig E. Lunte |
| 393-399 | Quantitative Analysis of the Active Tablet Ingredient by Powder X-Ray Diffractometry | Raj Suryanarayanan and Craig S. Herman |
| 400-402 | Determination of Degree of Substitution of Formyl Groups in Polyaldehyde Dextran by the Hydroxylamine Hydrochloride Method | Huiru Zhao and Ned D. Heindel |
| 403-408 | Solubilization and in Vitro Spermicidal Assessment of Nonoxynol-9 and Selected Fractions Using Rabbit Spermatozoa | Brian A. Walter, Amale A. Hawi, Panayiotis M. Zavos and George A. Digenis |
| 409-411 | High-Performance Liquid Chromatographic (HPLC) Analysis of Oligomeric Components of the Spermicide Nonoxynol-9 | Brian A. Walter and George A. Digenis |
| 412-414 | The Effect of Pancreatin on the Dissolution Performance of Gelatin-Coated Tablets Exposed to High-Humidity Conditions | Terrence C. Dahl, I-Lan T. Sue and Alicia Yum |
| 415-417 | Kinetics of Drug Action in Disease States. XL. Effect of the Dialyzable Component(s) of Uremic Blood on Theophylline Neurotoxicity in Rats | Amnon Hoffman and Gerhard Levy |
| 418 | BOOK REVIEWS |
| 419 | Letters to the Editor | Henry C. Caldwell and Samuel H. Yalkowsky |
| 420 | Association News and Announcements |
| 421-426 | Validation of Bioanalytical Methods | H. Thomas Karnes, Gerald Shiu and Vinod P. Shah |
| 427-436 | The Effects of Formulation Variables on the Stability of Freeze-Dried Human Growth Hormone | Michael J. Pikal, Karen M. Dellerman, Michael L. Roy and Ralph M. Riggin |
| 437-444 | Hepatic Disposition Characteristics of Electrically Charged Macromolecules in Rat in Vivo and in the Perfused Liver | Koyo Nishida, Kiyoshi Mihara, Toichi Takino, Sachi Nakane and Yoshinobu Takakura, et al. |
| 445-454 | Colon-Specific Delivery of Dexamethasone from a Glucoside Prodrug in the Guinea Pig | Thomas N. Tozer, Jean Rigod, Andrew D. McLeod, Ramon Gungon and M. Kim Hoag, et al. |
| 455-461 | Amine Prodrugs Which Utilize Hydroxy Amide Lactonization. II. A Potential Esterase-Sensitive Amide Prodrug | Kent L. Amsberry, A. Elise Gerstenberger and Ronald T. Borchardt |
| 462-470 | Molecular Structure and Dynamics of cis(Z)- and trans(E)-Flupenthixol and Clopenthixol | Ingebrigt Sylte and Svein G. Dahl |
| 471-474 | Effects of Viscous Hyaluronate–Sodium Solutions on the Nasal Absorption of Vasopressin and An Analogue | Kazuhiro Morimoto, Hiroshi Yamaguchi, Yasushi Iwakura, Katsuaki Morisaka and Yoshihiro Ohashi, et al. |
| 475-479 | In Vitro Evaluation of the Plasma and Blood Compatibility of a Parenteral Formulation for Ditekiren, a Novel Renin Inhibitor Pseudopeptide | John C. Greenfield, Sheryl J. Loux, Virendra K. Sood, Kathryn M. Jenkins and Stephen R. Davio |
| 480-484 | Inactivation Kinetics of Enzyme Pharmaceuticals in Aqueous Solution | Sumie Yoshioka, Ken-ichi Izutsu, Yukio Aso and Yasushi Takeda |
| 485-490 | Stability of Interleukin 1β (IL-1β) in Aqueous Solution: Analytical Methods, Kinetics, Products, and Solution Formulation Implications | Leo C. Gu, Elizabeth A. Erdös, Hi-Shi Chiang, Thomas Calderwood and Kelly Tsai, et al. |
| 491-497 | Effect of Polyethylene Glycol 400 on the Intestinal Permeability of Carbamazepine in the Rabbit | Lillian E. Riad and Ronald J. Sawchuk |
| 498-501 | Effects of Deoxycholate on the Transepithelial Transport of Sucrose and Horseradish Peroxidase in Filter-Grown Madin–Darby Canine Kidney (MDCK) Cells | Yi-Jing Lin and Wei-Chiang Shen |
| 502-504 | Cosolvency of Dimethyl Isosorbide for Steroid Solubility | Hossein Zia, Joseph K. H. Ma, John P. O'Donnell and Louis A. Luzzi |
| 505-507 | Molecular Motion of Drugs in Hydrocolloids Measured by Electron Paramagnetic Resonance | Julijana Kristl, Slavko Pečar, Jelka Šmid-Korbar and Milan Schara |
| 508-511 | Mean Residence Times and Distribution Volumes for Drugs Undergoing Linear Reversible Metabolism and Tissue Distribution and Linear or Nonlinear Elimination from the Central Compartments | Haiyung Cheng and William J. Jusko |
| 512-517 | Suitability of Various Noninfinity Area Under the Plasma Concentration–Time Curve (AUC) Estimates for Use in Bioequivalence Determinations: Relationship to AUC from Zero to Time Infinity (AUCO–INF) | Marilyn N. Martinez and Andre J. Jackson |
| 518-522 | The Preparation and Evaluation of a Tablet Dosage Form of Cyclosporine in Dogs | Hisham Y. Abdallah and Michael Mayersohn |
| 523-526 | High-Performance Liquid Chromatographic (HPLC) Determination of Lobenzarit in Plasma and Its Application to a Bioavailability Study in Beagle Dogs | Francis J. Schwende and Scott W. Turner |
| 527-530 | Synthesis of Poly(Hydroxypropylglutamine-Prazosin Carbamate) and Release Studies | Xiaoling Li, Nathan W. Adams, David B. Bennett, Jan Feijen and Sung Wan Kim |
| 531-537 | “On–Off” Thermocontrol of Solute Transport. I. Temperature Dependence of Swelling of N-Isopropylacrylamide Networks Modified with Hydrophobic Components in Water | You Han Bae, Teruo Okano and Sung Wan Kim |
| 538-540 | In Vitro Binding of Lorazepam and Lorazepam Glucuronide to Cholestyramine, Colestipol, and Activated Charcoal | Robert J. Herman and Archana Chaudhary |
| 541-543 | Determination of the Relative Formation and Elimination Clearance of Two Major Carbamazepine Metabolites in Humans: A Comparison Between Traditional and Pooled Sample Analysis | Lillian E. Riad, Keith K. Chan and Ronald J. Sawchuk |
| 544-546 | Drug Metabolism and Laboratory Anesthetic Protocols in the Rat: Examination of Antipyrine Pharmacokinetics | Mark Gumbleton and Leslie Z. Benet |
| 547-549 | Rapid High-Performance Liquid Chromatographic Analysis and Stability Study of Hydrocortisone 17-Butyrate in Cream Preparations | Sompon Wanwimolruk |
| 550 | Letters to the Editor | P. Macheras, C. Reppas, S. Antimisiaris, T. Stebler and T. W. Guentert |
| 551-556 | Stereoselectivity in Pharmacokinetics: A General Theory | René H. Levy and Alan V. Boddy |
| 557-562 | Comparison of the Methods for Determining Cell-Surface and Intracellular Receptors for Epidermal Growth Factor in the Rat Liver | Shigeo Yanai, Yuichi Sugiyama, Tatsuji Iga, Tohru Fuwa and Manabu Hanano |
| 563-569 | Effect of Receptor Up-Regulation on Insulin Pharmacokinetics in Streptozotocin-Treated Diabetic Rats | Hitoshi Sato, Tetsuya Terasaki, Kiminori Okumura and Akira Tsuji |
| 570-575 | Nonisothermal Stability Assessment of Stable Pharmaceuticals: Testing of a Clindamycin Phosphate Formulation | James E. Kipp and John J. Hlavaty |
| 576-583 | A Novel, Self-Correcting Membrane Coating Technique | Hitesh R. Bhagat, Robert W. Mendes, Edith Mathiowitz and Hridaya N. Bhargava |
| 584-587 | Sustained Pharmacological Activities in Rats Following Single and Repeated Administration of Once-a-Month Injectable Microspheres of Leuprolide Acetate | Hiroaki Okada, Toshiro Heya, Yasuaki Ogawa, Hajime Toguchi and Tsugio Shimamoto |
| 588-592 | Absorption Enhancing Effect of Cyclodextrins on Intranasally Administered Insulin in Rats | Frans W. H. M. Merkus, J. Coos Verhoef, Stefan G. Romeijn and Nicolaas G. M. Schipper |
| 593-599 | Structural Requirements for the Intestinal Mucosal-Cell Peptide Transporter: The Need for N-Terminal α-Amino Group | Pel-Fan Bai, Pullachipatti Subramanian, Henry I. Mosberg and Gordon L. Amidon |
| 600-604 | Use of Modified Ethylcellulose Lattices for Microporous Coating of Osmotic Tablets | Leah E. Appel and Gaylen M. Zentner |
| 605-607 | Bioavailability of Flurbiprofen Following Buccal Administration | Dennis J. Stalker and Steven R. Pollock |
| 608-614 | Dose-Dependent Pharmacokinetics of MK-417, a Potent Carbonic Anhydrase Inhibitor, in Experimental Polycythemic and Anemic Rats | Jiunn H. Lin, I-Wu Chen and Florencia A. deLuna |
| 615-618 | Determination of Sodium and Chloride Ions in Teicoplanin Lyophilized Vials by Nonsuppressed, Single-Column Ion Chromatography | Miguel A. de Soto-Perera |
| 619-623 | High-Performance Liquid Chromatographic Determination of 2′, 3′ -Didehydro-3′ -deoxythymidine (d4T) in Human and Rabbit Plasma and Urine and Its Application to Pharmacokinetic Studies in the Rabbit | Shekman L. Wong and Ronald J. Sawchuk |
| 624-628 | “On–Off“ Thermocontrol of Solute Transport. II. Solute Release from Thermosensitive Hydrogels | You Han Bae, Teruo Okano and Sung Wan Kirn |
| 629-635 | Formulation and in Vitro Evaluation of Pressurized Inhalation Aerosols Containing Isotropic Systems of Lecithin and Water | Richard M. Evans, Stephen J. Farr, N. Anthony Armstrong and Sarah M. Chatham |
| 636-642 | Significance of Partial and Total Cohesion Parameters of Pharmaceutical Solids Determined from Dissolution Calorimetric Measurements | Catherine Rey-Mermet, Paul Ruelle, Hô Nam-Trân, Michel Buchmann and Ulrich W. Kesselring |
| 643-648 | Crystal Growth Kinetics of Theophylline Monohydrate | Naír Rodríguez-Hornedo and Hsiu-Jean Wu |
| 649-652 | Lipophilic Peptides: Synthesis of Lauroyl Thyrotropin-Releasing Hormone and Its Biological Activity | Shozo Muranishi, Atsushi Sakai, Keigo Yamada, Masahiro Murakami and Kanji Takada, et al. |
| 653-655 | Determination of Allopurinol and Oxypurinol in Rat Plasma, Intestinal Wash, and Bile by High-Performance Liquid Chromatography with Electrochemical Detection (HPLC/EC) Following Automated Solid Phase Extraction | Eugene J. Eisenberg, Phil Conzentino, Gary G. Liversidge and Kenneth C. Cundy |
| 656-657 | The Cytotoxicity of p-Chloro-m-xylenol in Primary Culture of Rat Hepatocytes | Julio C. Davila, Angelica Dorantes, Salomon A. Stavchansky and Daniel Acosta |
| 658-660 | Low First-Spray Drug Content in Albuterol Metered-Dose Inhalers | Terry D. Cyr, Susan J. Graham, K. Y. Robert Li and Edward G. Levering |
| 661-662 | Letters to the Editor | Bradley D. Anderson, Richard T. Darrington and Janardan B. Nagwekar |
| 663-675 | Introduction to Fourier Transform Infrared Spectroscopy and Applications in the Pharmaceutical Sciences | Robert J. Markovich and Charles Pidgeon |
| 676-682 | Pharmaceutical Sciences' Manpower Supply and Internal Rate of Return | Abraham G. Hartzema and Eleanor Perfetto |
| 683-689 | Assessment of Drug Disposition in the Perfused Rat Brain by Statistical Moment Analysis | Toshiyasu Sakane, Michiko Nakatsu, Akira Yamamoto, Mitsuru Hashida and Hitoshi Sezaki, et al. |
| 690-697 | In Vitro and in Vivo Investigations of Dihydropyridine-Based Chemical Delivery Systems for Anticonvulsants | Alan V. Boddy, Kanyin Zhang, Francis Lepage, Francis Tombret and J. Greg Slatter, et al. |
| 698-705 | Prediction of Physical Aging in Controlled-Release Coatings: The Application of the Relaxation Coupling Model to Glassy Cellulose Acetate | Christopher M. Sinko, Albert F. Yee and Gordon L. Amidon |
| 706-712 | A Polymer Carrier System for Taste Masking of Macrolide Antibiotics | Mou-ying Fu Lu, Saul Borodkin, Linda Woodward, Ping Li and Curt Diesner, et al. |
| 713-720 | Controlled Delivery Systems for Proteins Based on Poly(Lactic/Glycolic Acid) Microspheres | Smadar Cohen, Toshio Yoshioka, Melissa Lucarelli, Lena H. Hwang and Robert Langer |
| 721-727 | Degradation of Insulin by Trypsin and Alpha-Chymotrypsin | Robert J. Schilling and Ashim K. Mitra |
| 728-733 | Role of Enzymatic Lability in the Corneal and Conjunctival Penetration of Timolol Ester Prodrugs in the Pigmented Rabbit | Du-Shieng Chien, Hitoshi Sasaki, Hans Bundgaard, Anders Buur and Vincent H. L. Lee |
| 734-738 | The Preparation and Acute Antihypertensive Effects of a Nanocapsular Form of Darodipine, a Dihydropyridine Calcium Entry Blocker | Brigitte Hubert, Jeffrey Atkinson, Madeleine Guerret, Maurice Hoffman and Jean Philippe Devissaguet, et al. |
| 739-743 | The Bioavailability and Nonlinear Clearance of (–)-Carbovir in the Rat | Shu-hui Huang, Rory P. Remmel and Cheryl L. Zimmerman |
| 744-749 | Nitroglycerin Absorption from Transdermal Systems: Formulation Effects and Metabolite Concentrations | Roger L. Williams, Kamlesh M. Thakker, Vivian John, Emil T. Lin and Winnie Liang-Gee, et al. |
| 750-753 | Pharmacokinetics and Anticonvulsant Activity of Three Monoesteric Prodrugs of Valproic Acid | Khalil Badir, Abdulla Haj-Yehia, Tom B. Vree, Eppo Kleijn and Meir Bialer |
| 754-757 | Racial Differences in Drug Response: Isoproterenol Effects Before and After Propranolol | David R. Rutledge, Ann Wallace, Joel D. Steinberg, Lavoisier Cardozo and Steven J. Lavine |
| 758-762 | A High-Performance Liquid Chromatographic Assay for the Enantiomers of Bevantolol in Human Plasma | Steven E. Rose and Edward J. Randinitis |
| 763-770 | One-Dimensional and Two-Dimensional 1H- and 13C-Nuclear Magnetic Resonance (NMR) Analysis of Vitamin E Raw Materials or Analytical Reference Standards | John K. Baker and Chris W. Myers |
| 771-775 | Effects of 5′-Ester Modification on the Physicochemical Properties and Plasma Protein Binding of 5-Iodo-2′-deoxyuridine | Mridul K. Ghosh and Ashim K. Mitra |
| 776-781 | Quantitative Structure–Activity Relationship Analysis of Combretastatins: A Class of Novel Antimitotic Agents | Partha Nandy, Samitendu Banerjee, Hua Gao, Mary B. V. Hui and Eric J. Lien |
| 782-786 | Effect of Solution Phase Composition on the Interaction Between Aqueous Model Solutes and Polymeric Container Materials | Dennis R. Jenke |
| 787-791 | Pharmacokinetics of Once-a-Month Injectable Microspheres of Leuprolide Acetate | Hiroaki Okada, Yayoi Inoue, Toshiro Heya, Hayao Ueno and Yasuaki Ogawa, et al. |
| 792-795 | Use of 2-Hydroxypropyl-β-cyclodextrin as a Solubilizing and Stabilizing Excipient for Protein Drugs | Marcus E. Brewster, Maninder S. Hora, James W. Simpkins and Nicholas Bodor |
| 796-800 | Influence of Antibiotics on the Recovery and Kinetics of Saccharomyces boulardii in Rats | Alan V. Boddy, Gary W. Elmer, Lynne V. McFarland and René H. Levy |
| 801-803 | Studies in Phlebitis. II. Early Detection of Amiodarone-Induced Phlebitis in a Rabbit Model | Gary H. Ward, Paul E. Nolan, Milissa White and Samuel H. Yalkowsky |
| 804-805 | Pharmaceutical Marketing in the European Community: The 1992 Changes | Michael Dickson |
| 806 | Association News and Announcements |
| 807-814 | The Nasal Mucociliary Clearance: Relevance to Nasal Drug Delivery | Nicolaas G. M. Schipper, J. Coos Verhoef and Frans W. H. M. Merkus |
| 815-820 | In Vivo Transport of a Dynorphin-like Analgesic Peptide, E-2078, Through the Blood–Brain Barrier: An Application of Brain Microdialysis | Tetsuya Terasaki, Yoshiharu Deguchi, Hitoshi Sato, Ken-ichi Hirai and Akira Tsuji |
| 821-825 | Gas Chromatographic–Mass Spectrometric (GC-MS) Determination of MDL 72,222 and Four Metabolites in Monkey Plasma | Haiyung Cheng and Jonathan A. Ragner |
| 826-831 | Triplet-Sensitized Photooxygenation of Therapeutic Retinoids | Keith A. Humphries and Robert W. Curley |
| 832-839 | Structure–Metabolism Relationships in the Hydrolysis of Nicotinate Esters by Rat Liver and Brain Subcellular Fractions | Anne Durrer, Bernard Walther, Antonio Racciatti, Gilles Boss and Bernard Testa |
| 840-850 | A New Predictive Equation for the Solubility of Drugs Based on the Thermodynamics of Mobile Disorder | Paul Ruelle, Catherine Rey-Mermet, Michel Buchmann, Hô Nam-Tran and Ulrich W. Kesselring, et al. |
| 851-858 | The Importance of Surface Charge in the Optimization of Antigen–Adjuvant Interactions | Patricia M. Callahan, Andrew L. Shorter and Stanley L. Hem |
| 859-864 | Effects of Palytoxin on Guinea Pig Tracheal Strips | Casey P. Robinson and David R. Franz |
| 865-872 | Quantitative Evaluation of Ethanol Effects on Diffusion and Metabolism of β-Estradiol in Hairless Mouse Skin | Puchun Liu, William I. Higuchi, Wei-qi Song, Tamie Kurihara-Bergstrom and William R. Good |
| 873-876 | Enhancement of 3-Hydroxy-3-methylglutaryl–Coenzyme A (HMG–CoA) Reductase Inhibitor Efficacy Through Administration of a Controlled-Porosity Osmotic Pump Dosage Form | Gregory A. McClelland, R. John Stubbs, Joseph A. Fix, Stefano A. Pogany and Gaylen M. Zentner |
| 877-882 | Variable Glyceryl Dinitrate Formation Following Infusions of Glyceryl Trinitrate at Different Vascular Sites in the Rat | Emi Nakashima, David T.-W. Lau and Leslie Z. Benet |
| 883-887 | Steady-State Pharmacokinetics and Pharmacodynamics of Benazeprilat in Spontaneously Hypertensive Rats (SHR) and Wistar–Kyoto (WKY) Rats | Sheryl LeRoy and Bret Berner |
| 888-892 | Binding Study of the Fluorescence Probe l-Anilino-8-naphthalenesulfonate to Human Plasma and Human and Bovine Serum Albumin Using Potentiometric Titration | Georgia N. Valsami, Panayotis E. Macheras and Michael A. Koupparis |
| 893-898 | The Relationship of Diastereomer Hydrolysis Kinetics to Shelf-Life Predictions for Cefuroxime Axetil | Ngoc-Anh T. Nguyen |
| 899-902 | A Simple and Rapid Method for the Quantification of Eudragit RS100 and RL100 Poly(methacrylates) in Sustained-Release Dosage Forms | Colin D. Melia, Bashir R. Hansraj, Karrar A. Khan and Ian R. Wilding |
| 903-907 | Electroanalytical Characteristics of the Cardiotonics, Enoximone and Piroximone | Carl L. Housmyer and Roy L. Lewis |
| 908-912 | X-Ray Structure and Crystal Lattice Interactions of the Taxol Side-Chain Methyl Ester | John R. Peterson, Hoang D. Do and Robin D. Rogers |
| 913-918 | An Electrically Modulated Drug Delivery Device: I | Antony D'Emanuele and John N. Staniforth |
| 919-924 | Tablet Formulation Study of Spray-Dried Sodium Diclofenac Enteric-Coated Microcapsules | Shan-Yang Lin and Yuh-Horng Kao |
| 925-929 | Insulin Aggregation in Aqueous Media and Its Effect on Alpha-Chymotrypsin-Mediated Proteolytic Degradation | Fang-yu Liu, Dane O. Kildsig and Ashim K. Mitra |
| 930-932 | Pharmacodynamics and Biophasic Drug Levels of Methionine Enkephalin | Randall J. Erb, Lih-Min Her, Anna Abdallah and Ashim K. Mitra |
| 933-937 | Dodecyl N,N-Dimethylamino Acetate and Azone Enhance Drug Penetration Across Human, Snake, and Rabbit Skin | Jouni Hirvonen, J. Howard Rytting, Petteri Paronen and Arto Urtti |
| 938-944 | Cotransport of Estradiol and Ethanol Through Human Skin in Vitro: Understanding the Permeant/Enhancer Flux Relationship | Puchun Liu, Tamie Kurihara-Bergstrom and William R. Good |
| 945-950 | Rectal Mucosa Damage in Rabbits After Subchronical Application of Suppository Bases | Christian De Muynck, Claude Cuvelier, Danny Van Steenkiste, Luc Bonnarens and Jean Paul Remon |
| 951-957 | Structural Effects on the Binding of Amine Drugs with the Diphenylmethyl Functionality to Cyclodextrins. I. A Microcalorimetric Study | Wei-Qin Tong, John L. Lach, Ting-Fong Chin and J. Keith Guillory |
| 958-961 | Controlled Delivery of Diphtheria Toxoid Using Biodegradable Poly(D,L-Lactide) Microcapsules | Manmohan Singh, Amarjit Singh and Gursharan Prasad Talwar |
| 962 | BOOK REVIEWS |
| 962 | BOOK REVIEWS |
| 963-973 | Physical Characterization of Pharmaceutical Solids | Harry G. Brittain, Susan J. Bogdanowich, David E. Bugay, Joseph DeVincentis and Geoffrey Lewen, et al. |
| 974-978 | Spectrophotometric Prediction of the Dissolution Rate of Carbamazepine Tablets | Peter N. Zannikos, Wen-I Li, James K. Drennen and Robert A. Lodder |
| 979-988 | Predicting Fraction Dose Absorbed in Humans Using a Macroscopic Mass Balance Approach | Patrick J. Sinko, Glen D. Leesman and Gordon L. Amidon |
| 989-991 | Determination of Clarithromycin as a Contaminant on Surfaces by High-Performance Liquid Chromatography Using Electrochemical Detection | Terry D. Rotsch, Meredith Spanton, Phyllis Cugier and Andrew C. Plasz |
| 992-996 | Simultaneous High-Performance Liquid Chromatographic Analysis of Cefprozil Diastereomers in a Pharmacokinetic Study | Wen Chyi Shyu, Umesh A. Shukla, Vinod R. Shah, Eugene A. Papp and Rashmi H. Barbhaiya |
| 997-1001 | Column-Switching High-Performance Liquid Chromatography for On-Line Simultaneous Determination and Resolution of Enantiomers of Verapamil and Its Metabolites in Plasma | Yoshiya Oda, Naoki Asakawa, Takashi Kajima, Yutaka Yoshida and Tadashi Sato |
| 1002-1005 | Synthesis of the Enantiomers of Reduced Haloperidol | Juan C. Jaen, Bradley W. Caprathe, Stephen Priebe and Lawrence D. Wise |
| 1006-1012 | Quantitative Structure–Activity Relationship (QSAR) Analysis of the Cytotoxicities Of Aminohydroxyguanidine Derivatives and Their Antiviral Activities in Vitro | Pou-Hsiung Wang, Mary B. V. Hui, Partha Nandy, Samitendu Banerjee and Hua Gao, et al. |
| 1013-1020 | The Solution Conformations of Lidocaine Analogues | Paul D. McMaster, Valerie J. Noris, Charles E. Stankard, Eugene W. Byrnes and Peter R. Guzzo |
| 1021-1026 | The Cryopreservation of Liposomes. 1. A Differential Scanning Calorimetry Study of the Thermal Behavior of a Liposome Dispersion Containing Mannitol During Freezing/Thawing | Herre Talsma, Mies J. van Steenbergen, Paul J. M. Salemink and Daan J. A. Crommelin |
| 1027-1031 | Biodegradable Nanospheres Containing Phthalocyanines and Naphthalocyanines for Targeted Photodynamic Tumor Therapy | Akbiri Labib, Vincent Lenaerts, Francois Chouinard, Jean-Christophe Leroux and René Ouellet, et al. |
| 1032-1038 | The Pharmacokinetics and Metabolism of Human Relaxins in Rhesus Monkeys | Bobbe L. Ferraiolo, John Winslow, Gary Laramee, Abbie Celniker and Paul Johnston |
| 1039-1043 | Evaluation of Mucoadhesive Polymers in Ocular Drug Delivery. I. Viscous Solutions | Nigel M. Davies, Stephen J. Fair, Jonathan Hadgraft and Ian W. Kellaway |
| 1044-1049 | Solubilization and Stabilization of a Benzylpenicillin Chemical Delivery System by 2-Hydroxypropyl-β-cyclodextrin | Emil Pop, Thorsteinn Loftsson and Nicholas Bodor |
| 1050-1055 | Absorptive Clearance of Carbamazepine and Selected Metabolites in Rabbit Intestine | Lillian E. Riad and Ronald J. Sawchuk |
| 1056-1058 | Bioavailability of Erythromycin Acistrate from Hard Gelatin Capsules Containing Sodium Bicarbonate | Martti Marvola, Sirkka Nykänen and Marja Nokelainen |
| 1059-1063 | Pharmacokinetic Study of an Iridoid Glucoside: Aucubin | Nan-Joo Suh, Chang-Koo Shim, Min Hwa Lee, Shin Keun Kim and Il-Moo Chang |
| 1064-1065 | Does Hydration Affect Intercellular Lipid Organization in the Stratum Corneum? | Vivien H. W. Mak, Russell O. Potts and Richard H. Guy |
| 1066-1068 | Physicochemical Stability of Nitrofurantoin Anhydrate and Monohydrate Under Various Temperature and Humidity Conditions | Makoto Otsuka, Reiko Teraoka and Yoshihisa Matsuda |
| 1069-1070 | Disposition of Sulfamethazine and N-Acetylsulfamethazine in the Rat | Craig K. Svensson, Hani Zaher and Mark Tomilo |
| 1071-1075 | In Vivo Percutaneous Penetration/Absorption, Washington, D.C., May 1989 | Vinod P. Shah, Gordon L. Flynn, Richard H. Guy, Howard I. Maibach and Hans Schaefer, et al. |
| 1076-1077 | Letters to the Editor | H. Egermann, Sanford Bolton and Samuel Yalkowsky |
| 1078 | ERRATUM |
| 1079-1086 | Liposomes and Nanoparticles in the Treatment of Intracellular Bacterial Infections | Patrick Couvreur, Elias Fattal and Antoine Andremont |
| 1087-1093 | Water-Soluble, Solution-Stable, and Biolabile N-Substituted (Aminomethyl)benzoate Ester Prodrugs of Acyclovir | Hans Bundgaard, Ejvind Jensen and Erik Falch |
| 1094-1102 | Valerian-Derived Sedative Agents. I. On the Structure and Spectral Assignment of the Constituents of Valmane Using the Selective INEPT Nuclear Magnetic Resonance Technique | Lee-Juian Lin, Geoffrey A. Cordell and Manuel F. Balandrin |
| 1103-1112 | Stability of the Thrombolytic Protein Fibrolase: Effect of Temperature and pH on Activity and Conformation | Denise Pretzer, Brenda S. Schulteis, Christopher D. Smith, David G. Vander Velde and James W. Mitchell, et al. |
| 1113-1120 | lontophoretic Delivery of Amino Acids and Amino Acid Derivatives Across the Skin in Vitro | Philip G. Green, Robert S. Hinz, Christopher Cullander, Grace Yamane and Richard H. Guy |
| 1121-1127 | lontophoretic Delivery of a Series of Tripeptides Across the Skin in Vitro | Philip G. Green, Robert S. Hinz, Aeri Kim, Francis C. Szoka and Richard H. Guy |
| 1128-1136 | Nuclear Magnetic Resonance (NMR) Spectroscopic Investigation of Interaction Energies of Ephedrine Stereoisomers in Noncrystalline Solids and Its Correlation with Thermodynamic Data | Walter F. Schmidt and Irwin L. Honigberg |
| 1137-1143 | The Effect of Plasticizers on Compatibility, Mechanical Properties, and Adhesion Strength of Drug-Free Eudragit E Films | Shan-Yang Lin, Chau-Jen Lee and Yih-Yih Lin |
| 1144-1150 | Self-Association of Nicotinamide in Aqueous Solution: Mass Transport, Freezing-Point Depression, and Partition Coefficient Studies | William N. Charman, Christine S. C. Lai, Barrie C. Finnin and Barry L. Reed |
| 1151-1154 | Cyclodextrin Sulfates: Characterization as Polydisperse and Amorphous Mixtures | Josef Pitha, Larry M. Mallis, Diane J. Lamb, Tetsumi Irie and Kaneto Uekama |
| 1155-1158 | Catalysis of Carbaryl Hydrolysis in Micellar Solutions of Cetyltrimethylammonium Bromide | Jatin M. Patel and Dale Eric Wurster |
| 1159-1165 | Solid-State Properties of Tobramycin | Alekha K. Dash and Raj Suryanarayanan |
| 1166-1174 | Formulation Influence on Conjunctival Penetration of Four Beta Blockers in the Pigmented Rabbit: A Comparison with Corneal Penetration | Paul Ashton, Samir K. Podder and Vincent H. L. Lee |
| 1175-1179 | Effects of Proteolytic Enzyme Inhibitors on the Nasal Absorption of Vasopressin and an Analogue | Kazuhiro Morimoto, Hiroshi Yamaguchi, Yasushi Iwakura, Makoto Miyazaki and Emi Nakatani, et al. |
| 1180-1185 | A Redox-Based Chemical Delivery System that Enhances Estradiol Distribution to the Brain: Disposition Studies in the Rat | Kerry S. Estes, Volker Keuth, Klaus Dietzel, Marcus E. Brewster and Nicholas S. Bodor, et al. |
| 1186-1190 | Stereoselective Systemic Disposition of Ibuprofen Enantiomers in the Dog | Hae-Young Ahn, Gordon L. Amidon and David E. Smith |
| 1191-1194 | Operational Evaluation of Three Commercial Configurations of Atropine/HI-6 Wet/Dry Autoinjectors | Janis W. Schlager, Theodore W. Dolzine, James R. Stewart, Gerald L. Wannarka and Ming L. Shih |
| 1195-1198 | Stereospeciflc High-Performance Liquid Chromatographic Assay of Sotalol in Plasma | Robert A. Carr, Robert T. Foster and Nadeem H. Bhanji |
| 1199-1202 | Permselective Characteristics of Rabbit Buccal Mucosa | Rajesh B. Gandhi and Joseph R. Robinson |
| 1203-1205 | Solubility of Mefenamic Acid Under Simulated Fed- and Fasted-State Conditions | Christopher N. TenHoor, Vassiliki Bakatselou and Jennifer Dressman |
| 1206-1209 | Determination of Drug Solubility in Aerosol Propellants | Richard N. Dalby, Elaine M. Phillips and Peter R. Byron |
| 1210-1213 | Determination of Release Limits: A General Methodology | Paul V. Allen, Gary R. Dukes and Mark E. Gerger |
| 1214 | Editorial |
| 1215-1222 | Photoreactivity of LY277359 Maleate, a 5-Hydroxytryptamine3 (5-HT3) Receptor Antagonist, in Solution | Gerold L. Mosher and Julianne McBee |
| 1223-1230 | Low Molecular Weight Proteins as Carriers for Renal Drug Targeting: Naproxen–Lysozyme | Eric J. F. Franssen, Ronald G. M. van Amsterdam, Jan Visser, Frits Moolenaar and Dick de Zeeuw, et al. |
| 1231-1237 | Percutaneous Penetration Kinetics of Nitroglycerin and Its Dinitrate Metabolites Across Hairless Mouse Skin in Vitro | Toshihiro Kikkoji, Mark Gumbleton, Naruhito Higo, Richard H. Guy and Leslie Z. Benet |
| 1238-1242 | Prodrugs of Peptides. 11. Chemical and Enzymatic Hydrolysis Kinetics of N-Acyloxymethyl Derivatives of a Peptide-like Bond | Hans Bundgaard and Gitte Juel Rasmussen |
| 1243-1247 | Antimicrobial Diterpenes of Croton sonderianus. II. ent-Beyer-15-en-18-oic Acid | James D. McChesney, Alice M. Clark and Edilberto R. Silveira |
| 1248-1252 | Application of Neural Computing in Pharmaceutical Product Development | Ajaz S. Hussain, Xuanqiang Yu and Robert D. Johnson |
| 1253-1257 | Hepatic Disposition Characteristics of 111In-Labeled Lactosaminated Bovine Serum Albumin in Rats | Koyo Nishida, Yukiko Eguchi, Toichi Takino, Yoshinobu Takakura and Mitsuru Hashida, et al. |
| 1258-1263 | Parenteral Peptide Formulations: Chemical and Physical Properties of Native Luteinizing Hormone-Releasing Hormone (LHRH) and Hydrophobic Analogues in Aqueous Solution | Michael F. Powell, Lynda M. Sanders, Alan Rogerson and Vicki Si |
| 1264-1269 | Solution Stability of the Monoclonal Antibody–Vinca Alkaloid Conjugate, KS1/4-DAVLB | Alice Riggin, Dean Clodfelter, Ann Maloney, Eugene Rickard and Eddie Massey |
| 1270-1273 | Assessment of Antiinflammatory Agents Using 125I-Labeled Human Serum Albumin to Quantify Footpad Edema Volume in the Rat | Douglas J. Ormrod and Thomas E. Miller |
| 1274-1280 | Differences in Transport Rate of Oxytocin and Vasopressin Analogues Across Proximal and Distal Isolated Segments of the Small Intestine of the Rat | Stefan Lundin, Niclas Pantzar, Anja Broeders, Mats Ohlin and Björn R. Weström |
| 1281-1285 | Correlation of the Gastric Emptying of Nondisintegrating Tablets with Gastrointestinal Motility | Alastair J. Coupe, Stanley S. Davis, David F. Evans and Ian R. Wilding |
| 1286-1291 | Mixed Micelles as a Proliposomal, Lymphotropic Drug Carrier | Andreas Supersaxo, Wayne R. Hein and Hans Steffen |
| 1292-1296 | In Vitro Evaluation of Sustained Drug Release from Biodegradable Elastomer | Ryoichi Wada, Suong-Hyu Hyon, Takayuhi Nakamura and Yoshito Ikada |
| 1297-1301 | Regional Variation in Oral Mucosal Drug Absorption: Permeability and Degree of Keratinization in Hamster Oral Cavity | Yuji Kurosaki, Toshihito Takatori, Hidekatsu Nishimura, Taiji Nakayama and Toshikiro Kimura |
| 1302-1306 | Intrinsic Lymphatic Partition Rate of Mepitiostane, Epitiostanol, and Oleic Acid Absorbed from Rat Intestine | Teruhisa Ichihashi, Haruki Kinoshita, Yasushi Takagishi and Hideo Yamada |
| 1307-1312 | Structural Effects on the Binding of Amine Drugs with the Diphenylmethyl Functionality to Cyclodextrins. II. A Molecular Modeling Study | Wei-Qin Tong, John L. Lach, Ting-Fong Chin and J. Keith Guillory |
| 1313-1317 | Formulation, Bioavailability, and Pharmacokinetics of Sustained-Release Potassium Chloride Tablets | Sevda Şenel, Yilmaz Çapan, Turgay Dalkara, Neriman İnanç and A. Atillâ Hincal |
| 1318-1322 | Evaluation of “True” Creatinine Clearance in Rats Reveals Extensive Renal Secretion | Inger M. Darling and Marilyn E. Morris |
| 1323-1328 | Fourier Transform-Raman Spectroscopy for the Qualitative and Quantitative Characterization of Sulfasalazine-Containing Polymeric Microspheres | Peter J. Watts, Andrew Tudor, Stephen J. Church, Patrick J. Hendra and Paul Turner, et al. |
| 1329-1334 | Chemical Stabilization of a Vasoactive S-Nitrosothiol with Cyclodextrins Without Loss of Pharmacologic Activity | John Anthony Bauer and Ho-Leung Fung |
| 1335-1340 | Dual-Isotope Imaging of Neutron-Activated Erbium-171 and Samarium-153 and the in Vivo Evaluation of a Dual-Labeled Bilayer Tablet by Gamma Scintigraphy | George A. Digenis, Erik P. Sandefer, Robert M. Beihn and Alan F. Parr |
| 1341-1342 | Studies in Phlebitis. III. Evaluation of Diazepam and Phenytoin | Milissa White and Samuel H. Yalkowsky |
| 1343 | Interspecies Differences in the Nasal Absorption of Insulin | F. W. H. M. Merkus, J. C. Verhoef, S. G. Romeijn and N. G. M. Schipper |
| 1344 | Association News and Announcements |
| 1345-1350 | Delivering Peptides to the Central Nervous System: Dilemmas and Strategies | William A. Banks, Abba J. Kastin and Carlos M. Barrera |
| 1351-1359 | Interspecies Scaling of Clearance and Volume of Distribution Data for Five Therapeutic Proteins | Joyce Mordenti, Sharon A. Chen, Jerome A. Moore, Bobbe L. Ferraiolo and James D. Green |
| 1360-1364 | Effect of Freezing on Aggregation of Human Growth Hormone | Brigitte M. Eckhardt, James Q. Oeswein and Thomas A. Bewley |
| 1365-1371 | Role of Paracellular Pathway in Nonelectrolyte Permeation Across Rat Colon Epithelium Enhanced by Sodium Caprate and Sodium Caprylate | Toyohiro Sawada, Takahiro Ogawa, Mikio Tomita, Masahiro Hayashi and Shoji Awazu |
| 1372-1376 | Synthesis and the Biological Evaluation of the Structural Units of Drummondin C | Hiranthi Jayasuriya, John K. Baker, Alice M. Clark and James D. McChesney |
| 1377-1383 | Development and Evaluation of Sustained-Release Ibuprofen-Wax Microspheres. I. Effect of Formulation Variables on Physical Characteristics | Christianah M. Adeyeye and James C. Price |
| 1384-1388 | 113Cd Nuclear Magnetic Resonance (NMR) Study of the Inhibitory Effect of Methylvinylether/Maleic Acid (PVM/MA) Copolymer on the Alkaline Phosphatase of Escherichia coli | John Afflitto, Karen Ann Smith, Manoj Patel, Anthony Esposito and Elke Jensen, et al. |
| 1389-1395 | Improved Delivery Through Biological Membranes. LVI. Pharmacological Evaluation of Alprenoxime—A New Potential Antiglaucoma Agent | Nicholas Bodor and Alaaeldin Elkoussi |
| 1396-1400 | Effect of Drug Loading and Molecular Weight of Cellulose Acetate Propionate on the Release Characteristics of Theophylline Microspheres | Atul J. Shukla and James C. Price |
| 1401-1407 | Mixture Experimental Design in the Development of a Mucoadhesive Gel Formulation | James S. Chu, Gordon L. Amidon, Norman D. Weiner and Arthur H. Goldberg |
| 1408-1412 | Viscometric Study of Polyacrylic Acid Systems as Mucoadhesive Sustained-Release Gels | James S. Chu, Ramachandran Chandrasekharan, Gordon L. Amidon, Norman D. Weiner and Arthur H. Goldberg |
| 1413-1417 | 14C-Isomazole Disposition in Man After Oral Administration | James R. Woodworth, Allyn F. DeLong, A.F. Fasola and Samuel Oldham |
| 1418-1423 | Chemical and Enzymatic Degradation of Ganciclovir Prodrugs: Enhanced Stability of the Diadamantoate Prodrug Under Acid Conditions | Michael F. Powell, Adina Magill, Nancy Chu, Kyle Hama and Cheng I. Mau, et al. |
| 1424-1429 | Interaction of Metronidazole with Antibiotics Containing the 2-Aminothiazole Moiety | Ajit B. Thakur, Mohamed Abdelnasser, Abu T. M. Serajuddin and Deodatt A. Wadke |
| 1430-1433 | Liquid Chromatographic Analysis of the Enantiomeric Impurities in Various (+)-Pseudoephedrine Samples | Sarma P. Duddu, Reza Mehvar and David J. W. Grant |
| 1434-1440 | A Sensitive Method for Quantitation of Rifabutin and Its Desacetyl Metabolite in Human Biological Fluids by High-Performance Liquid Chromatography (HPLC) | Richard C. Lewis, Naomi Z. Hatfield and Prem K. Narang |
| 1441-1443 | Evidence for Glucuronide Conjugation of p-Nitrophenol in the Caco-2 Cell Model | Susan Bjorge, Katherine L. Hamelehle, Reynold Homan, Steven E. Rose and Daniel A. Turluck, et al. |
| 1444-1447 | Racemization of Ibutilide in Solution: A Factor to Consider When Choosing to Develop the Racemate or a Single Enantiomer | William J. Lambert and Paula G. Timmer |
| 1448-1451 | Sensitive High-Performance Liquid Chromatographic (HPLC) Determination of Diphenhydramine in Plasma Using Fluorescence Detection | Christine L. Webb and Michael A. Eldon |
| 1452 | Association News and Announcements |
| 1453-1460 | The Influence of Peptide Structure on Transport Across Caco-2 Cells | Robert A. Conradi, Allen R. Hilgers, Norman F. H. Ho and Philip S. Burton |
| 1461-1469 | Solubilization and Wetting Effects of Bile Salts on the Dissolution of Steroids | Vassiliki Bakatselou, Richard C. Oppenheim and Jennifer B. Dressman |
| 1470-1476 | The Pharmacokinetics of Antipyrine and Three of Its Metabolites in the Rabbit: Intravenous Administration of Pure Metabolites | John V. St. Peter, Yusuf Abul-Hajj and Walid M. Awni |
| 1477-1481 | Desolvation Energy: A Major Determinant of Absorption, But Not Clearance, of Peptides in Rats | Michael S. Karls, Bob D. Rush, Karen F. Wilkinson, Thomas J. Vidmar and Philip S. Burton, et al. |
| 1482-1488 | In Vitro and in Vivo Evaluation of Whole and Half Tablets of Sustained-Release Adinazolam Mesylate | John W. Skoug, Marie T. Borin, Joseph C. Fleishaker and Anne M. Cooper |
| 1489-1494 | Experimental Determinations of Diffusion Coefficients in Dilute Aqueous Solution Using the Method of Hydrodynamic Stability | Marylee Z. Southard, Lloyd J. Dias, Kenneth J. Himmelstein and Valentino J. Stella |
| 1495-1499 | Effect of 2-Hydroxypropyl-β-cyclodextrin on the Ocular Absorption of Dexamethasone and Dexamethasone Acetate | Arunya Usayapant, Adel H. Karara and Milind M. Narurkar |
| 1500-1504 | Influence of Physical Aging on Mechanical Properties of Polymer Free Films: The Prediction of Long-Term Aging Effects on the Water Permeability and Dissolution Rate of Polymer Film-Coated Tablets | Jian-Hwa Guo, Richard E. Robertson and Gordon L. Amidon |
| 1505-1510 | Simultaneous Modeling of the Pharmacokinetics and Methemoglobin Pharmacodynamics of an 8-Aminoquinoline Candidate Antimalarial (WR 238605) | Ralf P. Brueckner and Lawrence Fleckenstein |
| 1511-1515 | Pharmacokinetics of Zopolrestat, a Carboxylic Acid Aldose Reductase Inhibitor, in Normal and Diabetic Rats | Philip B. Inskeep, Anne E. Reed and Robert A. Ronfeld |
| 1516-1519 | The Effect of Raising Gastric pH with Ranitidine on the Absorption and Elimination of Theophylline from a Sustained-Release Theophylline Tablet | Charles J. Betlach, Arthur B. Straughn, Marvin C. Meyer, Meir Bialer and V. I. Vashi, et al. |
| 1520-1524 | Stereoselective Disposition of Ibuprofen Enantiomers in the Isolated Perfused Rat Kidney | Hae-Young Ahn, Fakhreddin Jamali, Steven R. Cox, Dangnoi Kittayanond and David E. Smith |
| 1525-1527 | Determination of Cefsulodin, Cefmenoxime, and Cefadroxil as Residues on Surfaces | Ronald J. Gorski, Andrew C. Plasz, Lee Elrod, John Yoder and Landy B. White |
| 1528-1532 | The Stereospecific Determination of Fluoxetine and Norfluoxetine Enantiomers in Human Plasma by High-Pressure Liquid Chromatography (HPLC) with Fluorescence Detection | Albert L. Peyton, Russell Carpenter and Kathleen Rutkowski |
| 1533-1538 | Prodrugs of Peptides. 13. Stabilization of Peptide Amides Against α-Chymotrypsin by the Prodrug Approach | Anne H. Kahns and Hans Bundgaard |
| 1539-1542 | Improved Corneal Pilocarpine Permeability with O,O′-(l,4-Xylylene) Bispilocarpic Acid Ester Double Prodrugs | Pekka Suhonen, Tomi Järvinen, Päivi Rytkönen, Pekka Peura and Arto Urtti |
| 1543-1544 | Reviewers for Pharmaceutical Research (October 1990-October 1991) |
| 1545-1548 | Author Index to Volume 8 (1991) |
| 1549-1557 | Subject Index to Volume 8 (1991) |
| 1558 | Association News and Announcements |
| 1-9 | Drug Metabolism in the Nasal Mucosa | Mohamadi A. Sarkar |
| 10-16 | Composite Poly(vinyl alcohol) Beads for Controlled Drug Delivery | Cherng-Ju Kim and Ping I. Lee |
| 17-25 | Estimation of Permanence Time, Exit Time, Dilution Factor, and Steady-State Volume of Distribution | Joyce Mordenti and Aldo Rescigno |
| 26-32 | The Influence of Polymer Glass Transition Temperature and Molecular Weight on Drug Release from Tablets Containing Poly(DL-lactic Acid) | Marcelo O. Omelczuk and James W. McGinity |
| 33-36 | Lyophilized Formulations of Recombinant Tumor Necrosis Factor | Maninder S. Hora, Rajsharan K. Rana and Flint W. Smith |
| 37-39 | Controlled Protein Release from Polyethyleneimine-Coated Poly(L-lactic Acid)/Pluronic Blend Matrices | Tae Gwan Park, Smadar Cohen and Robert Langer |
| 40-44 | Localization of Epidermal Growth Factor (EGF) Binding Sites on Antiluminal Plasma Membrane of Rat Kidney: Autoradiographic Study Using Nonfiltering Perfused Rat Kidney | Dong Chool Kim, Yuichi Sugiyama, Yasushi Kanai, Norio Ohnuma and Manabu Hanano |
| 45-51 | Feasibility of Measuring the Bioavailability of Topical Betamethasone Dipropionate in Commercial Formulations Using Drug Content in Skin and a Skin Blanching Bioassay | Lynn K. Pershing, Barbara S. Silver, Gerald G. Krueger, Vinod P. Shah and Jerome P. Skelley |
| 52-57 | Tolerability and Absorption Enhancement of Intranasally Administered Octreotide by Sodium Taurodihydrofusidate in Healthy Subjects | Thomas Kissel, Juergen Drewe, Siegfried Bantle, Andreas Rummelt and Christoph Beglinger |
| 58-69 | Dissolution of lonizable Drugs into Unbuffered Solution: A Comprehensive Model for Mass Transport and Reaction in the Rotating Disk Geometry | Marylee Z. Southard, Don W. Green, Valentino J. Stella and Kenneth J. Himmelstein |
| 70-75 | A Surface Energy Analysis of Mucoadhesion: Contact Angle Measurements on Polycarbophil and Pig Intestinal Mucosa in Physiologically Relevant Fluids | Claus-Michael Lehr, Joke A. Bouwstra, Harry E. Boddé and Hans E. Junginger |
| 76-81 | Buffer Effects on Swelling Kinetics in Polybasic Gels | Ronald A. Siegel, Ingegerd Johannes, C. Anthony Hunt and Bruce A. Firestone |
| 82-86 | Influence of Formulation, Receptor Fluid, and Occlusion, on in Vitro Drug Release from Topical Dosage Forms, Using an Automated Flow-Through Diffusion Cell | Alain Rolland, Gilles Demichelis, Jean-Claude Jamoulle and Braham Shroot |
| 87-93 | Self-Emulsifying Drug Delivery Systems: Formulation and Biopharmaceutic Evaluation of an Investigational Lipophilic Compound | Susan A. Charman, William N. Charman, Mark C. Rogge, Terry D. Wilson and Frank J. Dutko, et al. |
| 94-100 | Complexation Studies of Cyclodextrins with Tricyclic Antidepressants Using Ion-Selective Electrodes | Georgia N. Valsami, Michael A. Koupparis and Panayotis E. Macheras |
| 101-108 | A Sensitive and Specific Procedure for Quantitation of ADR-529 in Biological Fluids by High-Performance Liquid Chromatography (HPLC) with Column Switching and Amperometric Detection | Richard C. Lewis, Barbara A. Phillips, John R. Baldwin, David T. Rossi and Prem K. Narang |
| 109-114 | Evaluation of the Physical Stability of Freeze-Dried Sucrose-Containing Formulations by Differential Scanning Calorimetry | Marcel P. W. M. te Booy, Rien A. de Ruiter and André L. J. de Meere |
| 115-118 | Analysis of Hydroxyurea in Capsules and Aqueous Solution and Stability Study with Capillary Gas Chromatography and Thermionic (N–P) Specific Detection | Adnan El-Yazigi and Sameer Al-Rawithi |
| 119-125 | Validation of a Column-Switching High-Performance Liquid Chromatographic (HPLC) Method for Determination of ML-1035 and Its Five Metabolites in Plasma | Be-Sheng Kuo, James C. Poole and Kin-Kai Hwang |
| 126-130 | Surface Characterization of Activated Charcoal by X-Ray Photoelectron Spectroscopy (XPS): Correlation with Phenobarbital Adsorption Data | Gerald M. Burke, Dale Eric Wurster, Mary J. Berg, Peter Veng-Pedersen and Dorothy D. Schottelius |
| 131-137 | Kinetics of Degradation of Levothyroxine in Aqueous Solution and in Solid State | Chong Min Won |
| 138-142 | Kinetic Study of the Transformation from Tetrahydrate to Monohydrate of a New Antiallergic, Sodium 5-(4-oxo-phenoxy-4H-quinolizine-3-carboxamide)-tetrazolate | Satoshi Kitamura, Toshiji Tada, Yoshihiko Okamoto and Tsutomu Yasuda |
| 143-148 | Bisacylphosphonates Inhibit Hydroxyapatite Formation and Dissolution in Vitro and Dystrophic Calcification in Vivo | Gershon Golomb, Ada Schlossman, Hanan Saadeh, Matilda Levi and Joel M. Van Gelder, et al. |
| 149-154 | Poly(L-lactic Acid) Microspheres Containing Neutron-Activatable Holmium-165: A Study of the Physical Characteristics of Microspheres Before and After Irradiation in a Nuclear Reactor | Russell J. Mumper and Michael Jay |
| 155-158 | Potential Use of Microdialysis in Pharmacokinetics: A Protein Binding Study | Marianne Ekblom, Margareta Hammarlund-Udenaes, Thomas Lundqvist and Per Sjöberg |
| 159-160 | Iceberg Formation and the Resulting Effects on Rates of Hydrolysis of Aspirin | Richard J. Prankerd |
| 160 | Editorial |
| 161-168 | Pharmacokinetic Analysis of Drug Absorption from Muscle Based on a Physiological Diffusion Model: Effect of Molecular Size on Absorption | Eiji Nara, Masaaki Masegi, Tetsuya Hatono and Mitsuru Hashida |
| 169-177 | An Experimental Design Strategy for Quantitating Complex Pharmacokinetic Models: Enterohepatic Circulation with Time-Varying Gallbladder Emptying as an Example | Yow-MingChen Wang and Richard H. Reuning |
| 178-181 | Potentiation of Cytotoxicity of Mitoxantrone Toward CHO-K1 Cells in Vitro by Dipyridamole | Pankaj B. Desai and Rajagopalan Sridhar |
| 182-186 | A Novel Approach for the Determination of the Pain-Producing Potential of Intravenously Injected Substances in the Conscious Rat | John M. Marcek, William J. Seaman and Royal J. Weaver |
| 187-190 | Cutaneous Metabolism of Nitroglycerin in Vitro. I. Homogenized Versus Intact Skin | Naruhito Higo, Robert S. Hinz, David T. W. Lau, Leslie Z. Benet and Richard H. Guy |
| 191-194 | Enhanced Bioavailability of Cefoxitin Using Palmitoyl L-Carnitine. I. Enhancer Activity in Different Intestinal Regions | Steven C. Sutton, Edward L. LeCluyse, Leilani Cammack and Joseph A. Fix |
| 195-199 | Hydrophobic Anionic Gel Beads for Swelling-Controlled Drug Delivery | Cherng-Ju Kim and Ping I. Lee |
| 200-205 | Biodegradable Pseudolatexes: The Chemical Stability of Poly(D,L-Lactide) and Poly (ε-Caprolactone) Nanoparticles in Aqueous Media | Mark D. Coffin and James W. McGinity |
| 206-210 | Development of Extended-Release Solid Dispersions of Nonsteroidal Antiinflammatory Drugs with Aqueous Polymeric Dispersions: Optimization of Drug Release via a Curve-Fitting Technique | Chris Ho and GeorgeChiaw-Chi Hwang |
| 211-214 | Determination of Lidocaine Concentrations in Skin After Transdermal Iontophoresis: Effects of Vasoactive Drugs | J.Edmond Riviere, Nancy A. Monteiro-Riviere and Alfred O. Inman |
| 215-219 | An Electrically Modulated Drug Delivery Device. II. Effect of Ionic Strength, Drug Concentration, and Temperature | Antony D'Emanuele and John N. Staniforth |
| 220-223 | Factors Affecting the Release Rate of Terbutaline from Liposome Formulations After Intratracheal Instillation in the Guinea Pig | Robert M. Fielding and Robert M. Abra |
| 224-227 | Pharmacokinetic Evaluation of Drug Interactions with Anti-Human Immunotrophic Virus (HIV) Drugs. III. 2′,3′-Dideoxycytidine (ddC) and Zidovudine in Monkeys | Mingxin Qian, Anne R. Swagler, Mehul Mehta, C. T. Vishwanathan and James M. Gallo |
| 228-235 | Competitive Inhibition of Zidovudine Clearance by Probenecid During Continuous Coadministration | Shekman L. Wong, Mohsen A. Hedaya and Ronald J. Sawchuk |
| 236-243 | Effect of Chronic Hypertension on the Blood–Brain Barrier Permeability of Libenzapril | Jian-ping Tang, Ashok Rakhit, Frank L. Douglas and Srikumaran Melethil |
| 244-249 | Bioavailability of Leuprolide Acetate Following Nasal and Inhalation Delivery to Rats and Healthy Humans | Akwete Adjei, Dean Sundberg, James Miller and Alexander Chun |
| 250-254 | Pharmaceutical Properties of Loracarbef: The Remarkable Solution Stability of an Oral 1-Carba-l-dethiacephalosporin Antibiotic | Carol E. Pasini and Joseph M. Indelicato |
| 255-259 | Development and Evaluation of a Novel Dissolution Apparatus for Medicated Chewing Gum Products | James N. Rider, Ed L. Brunson, Walter G. Chambliss, Robert W. Cleary and Ahmed H. Hikal, et al. |
| 260-265 | Prolonged Systemic Delivery of Peptide Drugs by Long-Circulating Liposomes: Illustration with Vasopressin in the Brattleboro Rat | Martin C. Woodle, Gert Storm, Mary S. Newman, Jill J. Jekot and Lila R. Collins, et al. |
| 266-270 | The Influence of Sucrose, Dextran, and Hydroxypropyl-β-cyclodextrin as Lyoprotectants for a Freeze-Dried Mouse IgG2a Monoclonal Antibody (MN12) | Maaike E. Ressing, Wim Jiskoot, Herre Talsma, Cor W. van Ingen and E.Coen Beuvery, et al. |
| 271-275 | Renal Tubular Handling of p-Aminohippurate and Epidermal Growth Factor (EGF) in Filtering and Nonfiltering Perfused Rat Kidneys | Dong-Chool Kim, Yuichi Sugiyama, Yasufumi Sawada and Manabu Hanano |
| 276-278 | Colonic Drug Delivery: Enhanced Release of Indomethacin from Cross-Linked Chondroitin Matrix in Rat Cecal Content | Abraham Rubinstein, David Nakar and Amnon Sintov |
| 279-280 | European Reviewers for Pharmaceutical Research (November 1990-November 1991) |
| 281 | Association News and Announcements |
| 283-290 | Hydrogels: Swelling, Drug Loading, and Release | Sung Wan Kim, You Han Bae and Teruo Okano |
| 291-297 | Pharmacokinetic/Dynamic Correlation of Pulmonary and Cardiac Effects of Fenoterol in Asthmatic Patients After Different Routes of Administration | Günther Hochhaus, Ernst-Wilhelm Schmidt, Karl L. Rominger and Helmut Möllmann |
| 298-302 | The Bilayer Floating Capsule: A Stomach-Directed Drug Delivery System for Misoprostol | Marianne Oth, Michel Franz, Jacques Timmermans and Andre Möes |
| 303-306 | Cutaneous Metabolism of Nitroglycerin in Vitro. II. Effects of Skin Condition and Penetration Enhancement | Naruhito Higo, Robert S. Hinz, David T. W. Lau, Leslie Z. Benet and Richard H. Guy |
| 307-311 | Rotating-Disk Dissolution Kinetics of Nitrofurantoin Anhydrate and Monohydrate at Various Temperatures | Makoto Otsuka, Reiko Teraoka and Yoshihisa Matsuda |
| 312-315 | An Electrically Modulated Drug Delivery Device. III. Factors Affecting Drug Stability During Electrophoresis | Antony D'Emanuele and John N. Staniforth |
| 316-319 | Simultaneous in Vitro Measurement of Intestinal Tissue Permeability and Transepithelial Electrical Resistance (TEER) Using Sweetana–Grass Diffusion Cells | Steven C. Sutton, Alexander E. Forbes, Robyn Cargill, Jerome H. Hochman and Edward L. LeCluyse |
| 320-325 | Intestinal Absorption of Peptides and Peptide Analogues: Implications of Fasting Pancreatic Serine Protease Levels and pH on the Extent of Oral Absorption in Dogs and Humans | Patrick J. Sinko |
| 326-331 | Mechanism and Site Dependency of Intestinal Mucosal Transport and Metabolism of Thymidine Analogues | Gee-Bae Park and Ashim K. Mitra |
| 332-338 | Analysis of Zidovudine Distribution to Specific Regions in Rabbit Brain Using Microdialysis | Shekman L. Wong, Yanfeng Wang and Ronald J. Sawchuk |
| 339-344 | Uptake and Stereoselective Binding of the Enantiomers of MK-927, a Potent Carbonic Anhydrase Inhibitor, by Human Erythrocytes in Vitro | Jiunn H. Lin, Tsu-Han Lin and Haiyung Cheng |
| 345-349 | Population Characteristics of Biological Systems Influenced by Multicomponent Random and Uniform Variation | Gregory M. Kochak |
| 350-356 | Use of a Pharmacokinetic Model Incorporating Discontinuous Gastrointestinal Absorption to Examine the Occurrence of Double Peaks in Oral Concentration–Time Profiles | A. Benjamin Suttle, Gary M. Pollack and Kirn L. R. Brouwer |
| 357-364 | Bacterial Monitoring in Vials Using a Spectrophotometric Assimilation Method | Leonard J. Galante, Michael A. Brinkley and Robert A. Lodder |
| 365-371 | The Structure of Celiprolol | Narendra Kumar, Christianna Strohbeck and Herman L. Ammon |
| 372-377 | New Water-Soluble Pilocarpine Derivatives with Enhanced and Sustained Muscarinic Activity | Pascal Druzgala, David Winwood, Malgorzata Drewniak-Deyrup, Scott Smith and Nicholas Bodor, et al. |
| 378-384 | The Anomalous Hydrolytic Behavior of 1-Phenylvinyl Phosphate | Albert S. Kearney and Valentino J. Stella |
| 385-389 | Evaluation of the Poisson Distribution for Estimating the Quality of Drug/Diluent Random Powder Mixtures. I. High Particle Size of the Drug Constituent | Herbert Egermann, Peter Frank and Anna Krumphuber |
| 390-397 | Optimized Formulation of Magnetic Chitosan Microspheres Containing the Anticancer Agent, Oxantrazole | Emad Eldin Hassan, Roy C. Parish and James M. Gallo |
| 398-405 | Mechanisms to Control Drug Release from Pellets Coated with a Silicone Elastomer Aqueous Dispersion | Terrence C. Dahl and I-Ian T. Sue |
| 406-409 | Effect of Surfactant Phase in Perfluorocarbon Emulsification Efficiency | Jean M. Pasternacki-Surian, Roger L. Schnaare and Edwin T. Sugita |
| 410-413 | A Novel Method for Determination of Sterility of Microcapsules and Measurement of Viability of Encapsulated Organisms | K. Keith Kwok and Diane J. Burgess |
| 414-418 | Application of Curdlan to Controlled Drug Delivery. I. The Preparation and Evaluation of Theophylline-Containing Curdlan Tablets | Motoko Kanke, Keiko Koda, Yoko Koda and Hirokazu Katayama |
| 419-424 | The Disposition of a Human Relaxin (hRlx-2) in Pregnant and Nonpregnant Rats | Paul A. Cossum, Kevin A. Dwyer, Michael Roth, Sharon A. Chen and Barbara Moffat, et al. |
| 425-434 | Sustained Delivery of Interleukin-2 from a Poloxamer 407 Gel Matrix Following Intraperitoneal Injection in Mice | Thomas P. Johnston, Monika A. Punjabi and Christopher J. Froelich |
| 435-439 | The Influence of Peptide Structure on Transport Across Caco-2 Cells. II. Peptide Bond Modification Which Results in Improved Permeability | Robert A. Conradi, Alien R. Hilgers, Norman F. H. Ho and Philip S. Burton |
| 440 | Association News and Announcements |
| 441-449 | Polyalkylcyanoacrylate Nanoparticles as Polymeric Carriers for Antisense Oligonucleotides | Christine Chavany, Trung Le Doan, Patrick Couvreur, Francis Puisieux and Claude Hélèna |
| 450-456 | Correlation of in Vitro Release Rate and in Vivo Absorption Characteristics of Four Chlorpheniramine Maleate Extended-Release Formulations | Parviz Mojaverian, Elaine Radwanski, Chin-Chung Lin, Phillip Cho and Winston A. Vadino, et al. |
| 457-463 | Pharmacokinetic and Pharmacodynamic Comparison of Immediate-Release and Sustained-Release Adinazolam Mesylate Tablets After Single- and Multiple-Dose Administration | Joseph C. Fleishaker and C. Eugene Wright |
| 464-468 | The Pharmacokinetics of Trilostane and Ketotrilostane in an Interconverting System in the Rat | J. Paul McGee and P. Nicholas Shaw |
| 469-473 | Saturable Tissue Binding and Imirestat Pharmacokinetics in Rats | Jenny Y. Chien, Christopher R. Banfield, Romulus K. Brazzell, Philip R. Mayer and John T. Slattery |
| 474-479 | Significance of Binding to Na,K-ATPase in the Tissue Distribution of Ouabain in Guinea Pigs | Hideyoshi Harashima, Michio Mamiya, Masayo Yamazaki, Yuichi Sugiyama and Yasufumi Sawada, et al. |
| 480-484 | The in Situ Acetylation of an Immobilized Human Serum Albumin Chiral Stationary Phase for High-Performance Liquid Chromatography in the Examination of Drug–Protein Binding Phenomena | Terence A. G. Noctor and Irving W. Wainer |
| 485-491 | An Air-Gap Enzyme Electrode: Development and Applications | Ravi M. Shanker, Nashed E. Nashed and Siegfried Lindenbaum |
| 492-496 | Stereoselective Enzymatic Hydrolysis of Various Ester Prodrugs of Ibuprofen and Flurbiprofen in Human Plasma | Niels Mørk and Hans Bundgaard |
| 497-503 | The in Vitro Enzymic Labilities of Chemically Distinct Phosphomonoester Prodrugs | Albert S. Kearney and Valentine J. Stella |
| 504-514 | Amino Acid Side-Chain Contributions to Free Energy of Transfer of Tripeptides from Water to Octanol | Aeri Kim and Francis C. Szoka Jr |
| 515-520 | Nebulization of Liposomes. III. The Effects of Operating Conditions and Local Environment | Ralph W. Niven, Teresa M. Carvajal and Hans Schreier |
| 521-528 | Infrared Imaging of Pharmaceutical Materials Undergoing Compaction | Simon R. Bechard and G. R. B. Down |
| 529-534 | Absorptive-Mediated Endocytosis of an Adrenocorticotropic Hormone (ACTH) Analogue, Ebiratide, into the Blood–Brain Barrier: Studies with Monolayers of Primary Cultured Bovine Brain Capillary Endothelial Cells | Tetsuya Terasaki, Susumu Takakuwa, Akira Saheki, Shuzo Moritani and Takesada Shimura, et al. |
| 535-540 | Aminopeptidase Activity in the Jejunal and Heal Peyer's Patches of the Albino Rabbit | Eiji Hayakawa and Vincent H. L. Lee |
| 541-546 | Phagocytosis of Nanoparticles by Human Immunodeficiency Virus (HlV)-Infected Macrophages: A Possibility for Antiviral Drug Targeting | Volker Schäfer, Hagen von Briesen, Reinhard Andreesen, Anne-Marie Steffan and Cathy Royer, et al. |
| 547-553 | Bioadhesion by Means of Specific Binding of Tomato Lectin | Claus-Michael Lehr, Joke A. Bouwstra, Wouter Kok, Arthur B. J. Noach and Albertus G. de Boer, et al. |
| 554-558 | Influence of Supersaturation on the Pharmacodynamic Effect of Bupranolol After Dermal Administration Using Microemulsions as Vehicle | Jens Kemken, Albrecht Ziegler and Bernd W. Müller |
| 559-564 | Sonophoresis. I. The Use of High-Frequency Ultrasound to Enhance Transdermal Drug Delivery | D. Bommannan, Hirohisa Okuyama, Paul Stauffer and Richard H. Guy |
| 565-569 | Characteristics of Association of Oleoyl Derivatives of 5-Fluorodeoxyuridine and Methotrexate with Low-Density Lipoproteins (LDL) | P. Chris de Smidt and Theo J. C. van Berkel |
| 570-574 | Physicochemical Properties of the Novel Heteropolyanion Antiviral Hexapotassium-α-vanado-11-tungstoborate (DuP 925) | Michael B. Maurin, Rodney D. Vickery, W. M. Bryant, III and Munir A. Hussain |
| 575-577 | 1H-Nuclear Magnetic Resonance (NMR) Studies on the Inclusion Complex of Prostaglandin El (PGE1 with α-Cyclodextrin | Bert Steffan, Wilfried Fischer, Günther Cordes, Ilona Habon and Robert Müller |
| 578-581 | A Flexible Automated Dissolution Testing System for Use with Either USP Apparatus 1 or USP Apparatus 2 | Jeanette D. Dunkle, Daniel J. Gleason and Gerard C. Hokanson |
| 582-584 | Determination of Dissociation Constants of Selected Cyclodextrin–Benzaldehyde Inclusion Complexes Using Pulse Polarography1 | Hee-Sook Choi, Ching-jer Chang and Adelbert M. Knevel |
| 585 | BOOK REVIEWS |
| 585-586 | BOOK REVIEWS |
| 586-587 | BOOK REVIEWS |
| 586-587 | BOOK REVIEWS |
| 588-592 | Analytical Methods Validation: Bioavailability, Bioequivalence and Pharmacokinetic Studies | Vinod P. Shah, Kamal K. Midha, Shrikant Dighe, Iain J. McGilveray and Jerome P. Skelly, et al. |
| 593-594 | Association News and Announcements |
| 595-600 | Stability Studies of Gabapentin in Aqueous Solutions | Elena Zour, Shahid A. Lodhi, Russell U. Nesbitt, Steven B. Silbering and Pravin R. Chaturvedi |
| 601-606 | Analytical Method Comparison Based upon Statistical Power Calculations | David J. Mazzo and Margaret Connolly |
| 607-612 | Effect of Water Mobility on Drug Hydrolysis Rates in Gelatin Gels | Sumie Yoshioka, Yukio Aso and Tadao Terao |
| 613-616 | Initial Studies on the N-Glucosylation of Phenobarbital by Mouse Liver Microsomes Using a Radiochemical High-Performance Liquid Chromatographic (HPLC) Method | William H. Soine, Hosai Safi and Richard B. Westkaemper |
| 617-622 | Kinetics and Mechanism of Isomerization of Cyclosporin A | Reza Oliyai and Valentino J. Stella |
| 623-625 | Microbial Production of a Crisnatol Metabolite | Charles D. Hufford, Saleh H. El-Sharkawy, Tannis M. Jurgens and Julie R. Mikell |
| 626-628 | A Phosphinic Acid Dipeptide Analogue to Stabilize Peptide Drugs During Their Intranasal Absorption | Munir A. Hussain, Marguerita S. L. Lim, Krishnaswamy S. Raghavan, Nancy J. Rogers and Rommel Hidalgo, et al. |
| 629-635 | Adsorption of Fluorescein Dyes on Albumin Microspheres | Kamel Egbaria and Michael Friedman |
| 636-642 | Prediction and Assessment of Flammability Hazards Associated with Metered-Dose Inhalers Containing Flammable Propellants | Richard N. Dalby |
| 643-647 | Analytical Control Procedures of Immunoreactivity for IgG and Fab Fragments Specific to Haptens | Nathalie J. Cano, Alain E. Sabouraud, Michel Urtizberea, Jean Carcagne and Michel Grandgeorge, et al. |
| 648-653 | Differences in the Enhancing Effects of Sodium Caprate on Colonic and Jejimal Drug Absorption | Mikio Tomita, Toyohiro Sawada, Takahiro Ogawa, Hiroyuki Ouchi and Masahiro Hayashi, et al. |
| 654-657 | Gastrointestinal Transit and Systemic Absorption of Captopril from a Pulsed-Release Formulation | Ian R. Wilding, Stanley S. Davis, Massoud Bakhshaee, Howard N. E. Stevens and Robert A. Sparrow, et al. |
| 658-662 | Heat-Induced Drug Release Rate and Maximal Targeting Index of Thermosensitive Liposome in Tumor-Bearing Mice | Katsumi Iga, Yasuaki Ogawa and Hajime Toguchi |
| 663-669 | Predicting Skin Permeability | Russell O. Potts and Richard H. Guy |
| 670-676 | Equilibrium and Kinetic Factors Influencing Bile Sequestrant Efficacy | Paul E. Luner and Gordon L. Amidon |
| 677-682 | Pharmacokinetic and Metabolic Disposition of p-Chloro-m-xylenol (PCMX) in Dogs | Angelica Dorantes and Salomon Stavchansky |
| 683-686 | Effect of an Acute Dose of Alcohol on the Pharmacokinetics of Oral Nifedipine in Humans | Saeed Qureshi, Sylvie Laganière, Gilles Caillé, Denys Gossard and Yves Lacasse, et al. |
| 687-689 | Esterase Activity Toward the Diastereomers of Cefuroxime Axetil in the Rat and Dog | Gerold L. Mosher, Julianne McBee and David B. Shaw |
| 690-693 | Molecular Complexation: β-Cyclodextrin and Benzaldehyde Inclusion Complex | Hee-Sook Choi, Adelbert M. Knevel and Ching-jer Chang |
| 694-696 | Pharmacokinetics of Droperidol in Healthy Volunteers Following Intravenous Infusion and Rectal Administration from an Osmotic Drug Delivery Module | Suneel K. Gupta, Mary Southam and Stephen Hwang |
| 697-699 | Enhanced Bioavailability of 6-Mercaptopurine After Rectal Administration in Rats | Yasuhisa Kato, Takeji Matsushita, Tomomasa Yokoyama and Kiminori Mohri |
| 700 | BOOK REVIEWS |
| 700-701 | BOOK REVIEWS |
| 702 | Association News and Announcements |
| 703-714 | Anti-AIDS Drug Development: Challenges and Strategies | Prem Mohan |
| 715-726 | Chemical Stability of Insulin. 1. Hydrolytic Degradation During Storage of Pharmaceutical Preparations | Jens Brange, Liselotte Langkj\sgmaelig;r, Svend Havelund and Aage Vølund |
| 727-734 | Chemical Stability of Insulin. 2. Formation of Higher Molecular Weight Transformation Products During Storage of Pharmaceutical Preparations | Jens Brange, Svend Havelund and Philip Hougaard |
| 735-738 | Derivatives of 4-(2-N,N-Di-n-propylaminoethyl)-5-hydroxyindole: Synthesis and Pharmacological Effects | Joseph G. Cannon, Ioannis Roufos, Sheng Xing Ma and John Paul Long |
| 739-742 | Structural Modification Study of Anthracyclinones: Synthesis and Biological Activity of Several Derivatives of η-Pyrromycinone | Dun-Fu Liu, Hui Xiong and Chia-Chung Cheng |
| 743-749 | Improved Delivery Through Biological Membranes. XLV. Synthesis, Physical-Chemical Evaluation, and Brain Uptake Studies of 2-Chloroethyl Nitrosourea Delivery Systems | Krishnaswamy Raghavan, Thorsteinn Loftsson, Marcus E. Brewster and Nicholas Bodor |
| 750-752 | Parenteral Formulation of the Kappa Agonist Analgesic, DuP 747, via Micellar Solubilization | Munir A. Hussain, Lei-Shu Wu, Christopher Koval and Arthur R. Hurwitz |
| 753-758 | Acceleration of Heat Transfer in Vial Freeze-Drying of Pharmaceuticals. II. A Fluid Cushion Device | Samuel H. Yalkowsky and Suresh D. Patel |
| 759-763 | Microencapsulation of Solid Dispersions: Release of Griseofulvin from Griseofulvin:Phospholipid Coprecipitates in Microspheres | Gopi K. Vudathala and James A. Rogers |
| 764-768 | The Pharmacokinetics of Pulmonary-Delivered Insulin: A Comparison of Intratracheal and Aerosol Administration to the Rabbit | Paul Colthorpe, Stephen J. Farr, Glyn Taylor, lan J. Smith and David Wyatt |
| 769-775 | Conjunctival Penetration of Insulin and Peptide Drugs in the Albino Rabbit | Eiji Hayakawa, Du-Shieng Chien, Kazuhiro Inagaki, Akira Yamamoto and Wei Wang, et al. |
| 776-781 | Immobilization of Active Urokinase on Albumin Microspheres: Use of a Chemical Dehydrant and Process Monitoring | Kumaril Bhargava and Howard Y. Ando |
| 782-787 | Macrophage Activation by Polymeric Nanoparticles of Polyalkylcyanoacrylates: Activity Against Intracellular Leishmania donovani Associated with Hydrogen Peroxide Production | Rogério Gaspar, Veronique Préat, Fred R. Opperdoes and Michel Roland |
| 788-791 | The Mobile Order Theory Versus UNIFAC and Regular Solution Theory-Derived Models for Predicting the Solubility of Solid Substances | Paul Ruelle, Michel Buchmann, Hô Nam-Tran and Ulrich W. Kesselring |
| 792-799 | Cholesterol (Thermodynamic) Activity Determinations in Bile Salt–Lecithin–Cholesterol Systems and Cholesterol-Rich Liquid Crystalline Mesophase Formation | Uday K. Jain, William I. Higuchi, Chen L. Liu, Paul H. Lee and Norman A. Mazer |
| 800-807 | Plasma Concentration Clamping in the Rat Using a Computer-Controlled Infusion Pump | Lars L. Gustafsson, William F. Ebling, Eileen Osaki, Sandy Harapat and Donald R. Stanski, et al. |
| 808-811 | Stability of the New Anticancer Platinum Analogue 1,2-Diaminomethyl-Cyclobutane-Platinum(II)-Lactate (Lobaplatin; D19466) in Intravenous Solutions | Henk-Jan Guchelaar, Donald R. A. Uges, Paul Aulenbacher, Elisabeth G. E. de Vries and Nanno H. Mulder |
| 812-816 | Simultaneous Microdetermination of Rifampin, Deacetylrifampin, Isoniazid, and Acetylisoniazid in Plasma by Liquid Chromatography with Dual Electrochemical and Spectrophotometric Detection | Adnan El-Yazigi and Dale A. Raines |
| 817-821 | Comparison of Azone and Hexamethylene Lauramide in Toxicologic Effects and Penetration Enhancement of Cimetidine in Rabbit Eyes | I. Maged Ismail, Chi-Chu Chen, Joseph B. Richman, Jon S. Andersen and Diane D.-S. Tang-Liu |
| 822-825 | Pharmacokinetics of Oral 2′,3′-Dideoxyinosine in Rats | M. Guillaume Wientjes and Jessie L.-S. Au |
| 826-833 | Opportunities for Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development | Carl C. Peck, William H. Barr, Leslie Z. Benet, Jerry Collins and Robert E. Desjardins, et al. |
| 834 | Association News and Announcements |
| 835-844 | Biosensor Development | Jeffrey N. Roe |
| 845-849 | Reversal of Signs of Induced Cotton Effects of Dicumarol-α1-Acid Glycoprotein Systems by Phenothiazine Neuroleptics Through Ternary Complexation | Toshimi Miyoshi, Ryuji Yamamichi, Toru Maruyama and Masaki Otagiri |
| 850-855 | The Enantiomers of the Valproic Acid Analogue 2-n-Propyl-4-pentynoic Acid (4-yn-VPA): Asymmetric Synthesis and Highly Stereoselective Teratogenicity in Mice | Ralf-Siegbert Hauck and Heinz Nau |
| 856-859 | Microscopic Characterization of Particle Size and Shape: An Inexpensive and Versatile Method | Michael E. Houghton and Gregory E. Amidon |
| 860-863 | Sterile Filtration of a Parenteral Emulsion | Deborah M. Lidgate, Thomas Trattner, Richard M. Shultz and Richard Maskiewicz |
| 864-869 | Dissociation of Insulin Oligomers by Bile Salt Micelles and Its Effect on α-Chymotrypsin-Mediated Proteolytic Degradation | Yuping Li, Zezhi Shao and Ashim K. Mitra |
| 870-877 | Effect of Zinc Binding on the Structure and Stability of Fibrolase, a Fibrinolytic Protein from Snake Venom | Denise Pretzer, Brenda Schulteis, David G. Vander Velde, Christopher D. Smith and James W. Mitchell, et al. |
| 878-883 | Vaginal Absorption of Insulin in the Rat: Effect of Penetration Enhancers on Insulin Uptake and Mucosal Histology | Julie L. Richardson, Lisbeth Illum and Norman W. Thomas |
| 884-887 | The Influence of Different Strains and Age on in Vitro Rat Skin Permeability to Water and Mannitol | Ian P. Dick and Robert C. Scott |
| 888-893 | Oral Delivery of a Renin Inhibitor Compound Using Emulsion Formulations | Tugrul T. Kararli, Thomas E. Needham, Marty Griffin, Grant Schoenhard and Leonard J. Ferro, et al. |
| 894-900 | Intestinal Water and Solute Absorption Studies: Comparison of in Situ Perfusion with Chronic Isolated Loops in Rats | Hsiao-Hwa Lu, James D. Thomas, Josef J. Tukker and David Fleisher |
| 901-907 | Absorption of Flurbiprofen in the Fed and Fasted States | Jennifer B. Dressman, Rosemary R. Berardi, Grace H. Elta, Thomas M. Gray and Patricia A. Montgomery, et al. |
| 908-914 | Effect of Chronic Administration of Phenobarbital on the Hepatobiliary Transport of Phenol Red: Assessment by Statistical Moment Analysis | Toshiyuki Kakutani, Kaori Endo, Eiji Nara, Shigenobu Nakazora and Mitsuru Hashida |
| 915-919 | Multiple Oral Administration of a Ketoprofen–Dextran Ester Prodrug in Pigs: Assessment of Gastrointestinal Unavailability by Deconvolution | Frank Larsen, Bodil Hamborg Jensen, Henning Peter Olesen and Claus Larsen |
| 920-924 | An in Vitro Pharmacodynamic Model to Simulate Antibiotic Behavior of Acute Otitis Media with Effusion | Kyle Vance-Bryan, Tom A. Larson, Mark W. Garrison, John P. Toscano and Daniel M. Canafax, et al. |
| 925-928 | Bioequivalence | Aldo Rescigno |
| 929-932 | Method for the Determination of Diphenhydramine in Rabbit Whole Blood by High-Performance Liquid Chromatography (HPLC) with Ultraviolet (UV) Detection in Conjunction with Gas Chromatography (GC) with Mass Selective Detection (MSD) | Karen M. Walters-Thompson and William D. Mason |
| 933-938 | Investigation of the Degradation Mechanism of 5-Aminosalicylic Acid in Aqueous Solution | Rita K. Palsmeier, Donna M. Radzik and Craig E. Lunte |
| 939-944 | Solid-State Stability Testing of Drugs by Isothermal Calorimetry | Michael J. Koenigbauer, Stephen H. Brooks, Gregory Rullo and Richard A. Couch |
| 945-951 | Application of Electrospray Mass Spectrometry (ES-MS) for the Analysis of Monoclonal Antibody Fc Subunits | Wim Jiskoot, Gerrit van de Werken, José M. Coco Martin, Brian N. Green and E. Coen Beuvery, et al. |
| 952-954 | Transdermal Delivery of Insulin to Alloxan-Diabetic Rabbits by Ultrasound Exposure | Katsuro Tachibana |
| 955-957 | Electric Current-Sensitive Drug Delivery Systems Using Sodium Alginate/Polyacrylic Acid Composites | Soon Hong Yuk, Sun Hang Cho and Hai Bang Lee |
| 958-959 | Ideal Solubility of a Solid Solute: Effect of Heat Capacity Assumptions | Dinesh S. Mishra and Samuel H. Yalkowsky |
| 960-962 | Physical Properties of Fast-Release Nonreverting Hydrochlorothiazide Solid Dispersions | Mahasen M. Meshali and Khairy E. Gabr |
| 963-965 | Etorphine Is an Opiate Analgesic Physicochemically Suited to Transdermal Delivery | Lynn M. Jolicoeur, M. Reza Nassiri, Charles Shipman Jr, Hoo-Kyun Choi and Gordon L. Flynn |
| 966 | BOOK REVIEWS |
| 966-967 | BOOK REVIEWS |
| 968 | Association News and Announcements |
| 969-978 | Structural Specificity of Mucosal-Cell Transport and Metabolism of Peptide Drugs: Implication for Oral Peptide Drug Delivery | Jane P. F. Bai and Gordon L. Amidon |
| 979-989 | Novel Animal Model for Evaluating Topical Efficacy of Antiviral Agents: Flux Versus Efficacy Correlations in the Acyclovir Treatment of Cutaneous Herpes Simplex Virus Type 1 (HSV-1) Infections in Hairless Mice | Paul H. Lee, Muh-Hwan Su, Earl R. Kern and William I. Higuchi |
| 990-992 | Protein–Peptide Interactions as Probed by Tryptophan Fluorescence: Serum Albumins and Enkephalin Metabolites | Sunil Jain, C. Vijaya Kumar and Devendra S. Kalonia |
| 993-1002 | An Implantable Dosage Form for the Treatment of Bone Infections | Alekha K. Dash and Raj Suryanarayanan |
| 1003-1009 | Pharmacodynamics of Insulin Following Intravenous and Enteral Administrations of Porcine-Zinc Insulin to Rats | Robert J. Schilling and Ashim K. Mitra |
| 1010-1017 | Antisense c-myc Oligodeoxyribonucleotide Cellular Uptake | Susanna Wu-Pong, Tania L. Weiss and C. Anthony Hunt |
| 1018-1023 | Measurement of Serum [3H]Tetracycline Kinetics and Indices of Kidney Function Facilitate Study of the Activity and Toxic Effects of Bisphosphonates in Bone Resorption | Gershon Golomb, Yael Eitan and Amnon Hoffman |
| 1024-1028 | Enhancement of Nasal Delivery of a Renin Inhibitor in the Rat Using Emulsion Formulations | Tugrul T. Kararli, Thomas E. Needham, Grant Schoenhard, David A. Baron and R. Eric Schmidt, et al. |
| 1029-1034 | The Transport Barrier of Epithelia: A Comparative Study on Membrane Permeability and Charge Selectivity in the Rabbit | Yongyut Rojanasakul, Li-Ying Wang, Meenakshi Bhat, Douglas D. Glover and Carl J. Malanga, et al. |
| 1035-1042 | Quantitative Evaluation of Aqueous Isopropanol Enhancement of Skin Flux of Terbutaline (Sulfate). I. Ion Associations and Species Equilibria in the Formulation | Puchun Liu, Tamie Kurihara-Bergstrom, Frank H. Clarke, Nina Gonnella and William R. Good |
| 1043-1047 | Sonophoresis. II. Examination of the Mechanism(s) of Ultrasound-Enhanced Transdermal Drug Delivery | D. Bommannan, Gopinathan K. Menon, Hirohisa Okuyama, Peter M. Elias and Richard H. Guy |
| 1048-1052 | Brain Parenchymal Metabolism of 5-Iodo-2′-Deoxyuridine and 5′-Ester Prodrugs | Mridul K. Ghosh and Ashim K. Mitra |
| 1053-1057 | Disposition, Bioavailability, and Serum Protein Binding of Pentachlorophenol in the B6C3F1 Mouse | Bruno G. Reigner, Jean F. Rigod and Thomas N. Tozer |
| 1058-1063 | Pharmacokinetic Analysis of the Structural Requirements for Forming “Stable” Analogues of Valpromide | Abdulla Haj-Yehia, Salim Hadad and Meir Bialer |
| 1064-1069 | Pilocarpine Disposition and Salivary Flow Responses Following Intravenous Administration to Dogs | Margaret L. Weaver, Jason M. Tanzer and Paul A. Kramer |
| 1070-1075 | Nonlinear Disposition of Intravenous 2′,3′-Dideoxyinosine in Rats | M. Guillaume Wientjes, Elora Mukherji and Jessie L-S. Au |
| 1076-1082 | Is ICRF-187 [(+)-1,2-Bis(3,5-dioxopiperazinyl-1-yl)propane] Unusually Reactive for an Imide? | Jay M. Sisco and Valentino J. Stella |
| 1083-1091 | Formation of the Racemic Compound of Ephedrine Base from a Physical Mixture of Its Enantiomers in the Solid, Liquid, Solution, or Vapor State | Sarma P. Duddu and David J. W. Grant |
| 1092-1095 | Aqueous Stability and Solubility of CI-988, a Novel “Dipeptoid” Cholecystokinin-B Receptor Antagonist | Albert S. Kearney, Surendra C. Mehta and Galen W. Radebaugh |
| 1096-1098 | Corticosteroid Pharmacodynamic Modeling: Osteocalcin Suppression by Prednisolone | Jeffrey A. Wald and William J. Jusko |
| 1099-1102 | Inhibition of Hepatic and Cutaneous Biotransformation of Resorufin Ethers Following Intraperitoneal Administration of 1-Aminobenzotriazole | Neil F. Oldfield, Mildred Mortillo, William A. Garland and Bruce A. Mico |
| 1103-1106 | Peptides Are Better Absorbed from the Lung than the Gut in the Rat | Jennifer L. Hoover, Bob D. Rush, Karen F. Wilkinson, Jeff S. Day and Philip S. Burton, et al. |
| 1107-1112 | Principles and Criteria in the Development and Optimization of Topical Therapeutic Products | Vinod P. Shah, Charan R. Behl, Gordon L. Flynn, William I. Higuchi and Hans Schaefer |
| 1113-1122 | Transport of Thyrotropin Releasing Hormone in Rabbit Buccal Mucosa in Vitro | Martin E. Dowty, Kim E. Knuth, Brian K. Irons and Joseph R. Robinson |
| 1123-1127 | Assessment of the Twin Impinger for Size Measurement of Metered-Dose Inhaler Sprays | Nicholas C. Miller, Virgil A. Marple, Robert K. Schultz and Wai Sing Poon |
| 1128-1131 | Calcium Alginate Beads as Core Carriers of 5-Aminosalicylic Acid | Shun Y. Lin and James W. Ayres |
| 1132-1136 | Indomethacin-Loaded Microspheres: Design and Preparation by a Multiple-Emulsification Technique and Their in Vitro Evaluation | Suranjana Roy, Manjusree Pal and Bijan K. Gupta |
| 1137-1144 | Evaluation of Mucoadhesive Polymers in Ocular Drug Delivery. II. Polymer-Coated Vesicles | Nigel M. Davies, Stephen J. Farr, Jonathan Hadgraft and Ian W. Kellaway |
| 1145-1151 | Percutaneous Absorption and Metabolism of Lonapalene in Psoriatic Skin | Paul A. Lehman, Raymond V. Tomlinson, Jerry I. Johnson, John E. Olerud and William A. Akers, et al. |
| 1152-1156 | Correlation Between the Inhibitory Effects of Basic Drugs on the Uptake of Cardiac Glycosides and Taurocholate by Isolated Rat Hepatocytes | Kazuho Okudaira, Masayo Yamazaki, Yasufumi Sawada, Yuichi Sugiyama and Tatsuji Iga, et al. |
| 1157-1163 | Cyclodextrins as Nasal Absorption Promoters of Insulin: Mechanistic Evaluations | Zezhi Shao, Ramesh Krishnamoorthy and Ashim K. Mitra |
| 1164-1167 | In Vivo Percutaneous Absorption of Hydrocortisone: Multiple-Application Dosing in Man | Joseph L. Melendres, Daniel A. W. Bucks, Etienne Camel, Ronald C. Wester and Howard I. Maibach |
| 1168-1172 | Effects of Transdermal Penetration Enhancers on the Permeability of Shed Snakeskin | Tomoo Itoh, Lori Wasinger, T. Marjukka Turunen and J. Howard Rytting |
| 1173-1176 | Enhanced Delivery of 5-Iodo-2′-Deoxyuridine to the Brain Parenchyma | Mridul K. Ghosh and Ashim K. Mitra |
| 1177-1183 | Direct Suppression of Phagocytosis by Amphipathic Polymeric Surfactants | Nancy Watrous-Peltier, Joanne Uhl, Vivian Steel, Lynne Brophy and Elaine Merisko-Liversidge |
| 1184-1189 | Nasal Membrane and Intracellular Protein and Enzyme Release by Bile Salts and Bile Salt-Fatty Acid Mixed Micelles: Correlation with Facilitated Drug Transport | Zezhi Shao and Ashim K. Mitra |
| 1190-1194 | Influence of Gastrointestinal Site of Drug Delivery on the Absorption Characteristics of Ranitidine | Melissa F. Williams, George E. Dukes, William Heizer, Yieng-Hau Han and David J. Hermann, et al. |
| 1195-1198 | Molecular Weight-Dependent Lymphatic Transfer of Exogenous Macromolecules from Large Intestine of Renal Insufficiency Rats | Hiroshi Yoshikawa, Kanji Takada and Shozo Muranishi |
| 1199-1202 | Quantitative Analysis of Mercaptoundecahydrododecaborate by Fourier Transform Infrared Spectroscopy | D. Robert Lu and Corey Munro |
| 1203-1208 | Solid-State Stability Studies of 13-cis-Retinoic Acid and All-trans-Retinoic Acid Using Microcalorimetry and HPLC Analysis | Xinyi Tan, Noel Meltzer and Siegfried Lindenbaum |
| 1209-1214 | An Unexpected Hydrolysis pH-Rate Profile, at pH Values Less than 7, of the Labile Imide, ICRF-187: (+)-1,2-Bis-(3,5 -dioxopiperazin-1-yl)propane | Jay M. Sisco and Valentino J. Stella |
| 1215-1218 | A New Application Chamber for Skin Penetration Studies in Vivo with Liquid Preparations | Claudia S. Leopold and Bernhard C. Lippold |
| 1219-1223 | Analysis of Pilocarpine and Its Degradation Products by Micellar Electrokinetic Capillary Chromatography | William N. Charman, Andrew J. Humberstone and Susan A. Charman |
| 1224-1226 | Survey of Chlorinated Hydrocarbons and Other Organic Volatile Impurities in Captopril Raw Materials and Tablets | Terry D. Cyr, Robert C. Lawrence and Edward G. Lovering |
| 1227-1230 | Determination of a Novel Calcium Channel Antagonist, Mepirodipine, in Plasma by Radioreceptor Assay Using (+)-[3H]PN 200-110 | Shizuo Yamada, Youmei Matsuoka, Naoko Suzuki, Noriaki Sugimoto and Yoshihisa Kato, et al. |
| 1231 | BOOK REVIEWS |
| 1231-1232 | BOOK REVIEWS |
| 1233-1234 | Letters to the Editor | Wolfgang Klement, Detlef Kindgen-Milles, John M. Marcek, William J. Seaman and Royal J. Weaver |
| 1234 | Obituary for Razia Zaman and Shahanara Zaman Saroya | L. Bernstam, I. Bernstein, K. Brabec, M. Brabec and R. Brown, et al. |
| 1235-1242 | Delivery of Plasmid DNA into Mammalian Cell Lines Using pH-Sensitive Liposomes: Comparison with Cationic Liposomes | Jean-Yves Legendre and Francis C. Szoka Jr |
| 1243-1251 | Regional Jejunal Perfusion, a New in Vivo Approach to Study Oral Drug Absorption in Man | Hans Lennernäs, Örjan Ahrenstedt, Roger Hällgren, Lars Knutson and Märta Ryde, et al. |
| 1252-1255 | Suppression of Inflammation by Cyclosporin A Is Mediated via a T Lymphocyte-Independent Process | Thomas E. Miller, Glenne Findon and Douglas J. Ormrod |
| 1256-1261 | Microdialysis Sampling for the Investigation of Dermal Drug Transport | Joseph M. Ault, Craig E. Lunte, Noel M. Meltzer and Christopher M. Riley |
| 1262-1267 | Acyclovir Permeation Enhancement Across Intestinal and Nasal Mucosae by Bile Salt-Acylcarnitine Mixed Micelles | Gee-Bae Park, Zezhi Shao and Ashim K. Mitra |
| 1268-1274 | Effect of Loading on Swelling-Controlled Drug Release from Hydrophobic Polyelectrolyte Gel Beads | Cherng-Ju Kim and Ping I. Lee |
| 1275-1278 | Metabolism, Distribution, and Transdermal Permeation of a Soft Corticosteroid, Loteprednol Etabonate | Nicholas Bodor, Thorsteinn Loftsson and Whei-mei Wu |
| 1279-1283 | Molecular Weight Changes in Polymer Erosion | Antony D’Emanuele, Jennifer Hill, Janet A. Tamada, Abraham J. Domb and Robert Langer |
| 1284-1289 | Dose Proportionality of Transdermal Nitroglycerin | R. C. Jewell, C. R. Banfield, D. A. Ruggirello, Y. W. Huang and P. K. Noonan, et al. |
| 1290-1294 | Metabolism of Testosterone During in Vitro Transport Across CACO-2 Cell Monolayers: Evidence for β-Hydroxysteroid Dehydrogenase Activity in Differentiated CACO-2 Cells | Anders Buur and Niels Mørk |
| 1295-1298 | High-Dose Methotrexate Does Not Affect the Pharmacodynamics of Phenobarbital Hypnotic Action but Decreases the Central Nervous System (CNS) Sensitivity to Pentylenetetrazol-Induced Maximal Seizures in Rats | Amnon Hoffman and Jose Alfon |
| 1299-1305 | Studies on the Excretion of Diazepam and Nordazepam into Milk for the Prediction of Milk-to-Plasma Drug Concentration Ratios | Thomas Stebler and Theodor W. Guentert |
| 1306-1313 | General Treatment of the Enterohepatic Recirculation of Drugs and Its Influence on the Area Under the Plasma Level Curves, Bioavailability, and Clearance | José-Esteban Peris-Ribera, Francisca Torres-Molina, M. Carmen Garcia-Carbonell, Juan Carlos Aristorena and Luis Granero |
| 1314-1320 | Kinetics and Mechanism of Degradation of a Cyclic Hexapeptide (Somatostatin Analogue) in Aqueous Solution | Ramesh Krishnamoorthy and Ashim K. Mitra |
| 1321-1323 | A Quantitative Structure-Activity Relationship (QSAR) Study of Alkylpyrazine Odor Modalities | Anna Tsantili-Kakoulidou and Lemont B. Kier |
| 1324-1329 | The Effects of N(4-Methylphenyl)diphenimide on Lipid Metabolism of Sprague Dawley Rats | Iris H. Hall, O. T. Wong, Rupendra Simlot and David J. Reynolds |
| 1330-1335 | Microparticles of Polyvinyl Alcohol for Nasal Delivery. I. Generation by Spray-Drying and Spray-Desolvation | Teck-Yeo Ting, Igor Gonda and Elizabeth M. Gipps |
| 1336-1340 | Participation of Macrogolstearate 400 Lamellar Phases in Hydrophilic Creams and Vesicles | Valentina Paspaleeva-Kühn and Eberhard Nürnberg |
| 1341-1346 | Benzoyl Peroxide Solubility and Stability in Hydric Solvents | Eric M. Chellquist and William G. Gorman |
| 1347-1350 | Predicting the Effect of Nonionic Surfactants on Dispersed Droplet Radii in Submicron Oil-in-Water Emulsions | Shawn Silvestri, Nandita Ganguly and Esmail Tabibi |
| 1351-1358 | Powdered Solution Technology: Principles and Mechanism | Spiros S. Spireas, Charles I. Jarowski and Bhagwan D. Rohera |
| 1359-1361 | In Vitro Oral Mucosal Absorption of Liposomal Triamcinolone Acetonide | Stefan J. Sveinsson and Michael Mezei |
| 1362-1364 | Nasal Absorption of Leucine Enkephalin in Rats and the Effects of Aminopeptidase Inhibition, as Determined from the Percentage of the Dose Unabsorbed | Munir A. Hussain and Bruce J. Aungst |
| 1365-1369 | High-Performance Liquid Chromatography Determination of Acitretin in Plasma and Its Application to a Pharmacokinetic Study in Human Subjects | Christian Surber, Jean-Philippe Laugier, Jean-Marie Geiger, Hot Bun and Alain Durand, et al. |
| 1370-1373 | Inhibition of myo-Inositol 1-Phosphatase by cis-l,2,3-Cyclohexanetriol 1-Phosphate, a Molecular Simplification of the Natural Substrate | Marc W. Harrold, Anong Sriburi, Paul Caimano, Hansheng Qi and David Seybert, et al. |
| 1374 | Association News and Announcements |
| 1375-1379 | Monoclonal Antibodies in Hapten Immunoassays | Olivier N. Chappey, Pierre Sandouk and Jean-Michel G. Scherrmann |
| 1380-1385 | An Alternative Approach for Assessment of Rate of Absorption in Bioequivalence Studies | Mei-Ling Chen |
| 1386-1393 | Identification of Sites of Degradation in a Therapeutic Monoclonal Antibody by Peptide Mapping | Daniel J. Kroon, Alysia Baldwin-Ferro and Praful Lalan |
| 1394-1401 | Localization of Binding Sites for Epidermal Growth Factor (EGF) in Rat Kidney: Evidence for the Existence of Low Affinity EGF Binding Sites on the Brush Border Membrane | Dong Chool Kim, Manabu Hanano, Yasushi Kanai, Norio Ohnuma and Yuichi Sugiyama |
| 1402-1409 | Skin Alteration and Convective Solvent Flow Effects During Iontophoresis II. Monovalent Anion and Cation Transport Across Human Skin | Sandra M. Sims, William I. Higuchi and V. Srinivasan |
| 1410-1414 | Noninvasive in Vivo Percutaneous Absorption Measurements Using X-Ray Fluorescence | J. David Robertson, Elizabeth Ferguson, Michael Jay and Dennis J. Stalker |
| 1415-1421 | Lamellar Structures Formed by Stratum Corneum Lipids in Vitro: A Deuterium Nuclear Magnetic Resonance (NMR) Study | William Abraham and Donald T. Downing |
| 1422-1427 | Local Enhanced Topical Delivery (LETD) of Drugs: Does It Truly Exist? | Stephen C. McNeill, Russell O. Potts and Michael L. Francoeur |
| 1428-1435 | Physicochemical Properties of Salts of p-Aminosalicylic Acid. I. Correlation of Crystal Structure and Hydrate Stability | Robert T. Forbes, Peter York, Victor Fawcett and Leonard Shields |
| 1436-1441 | In Vivo Evaluation of Enteric-Coated Naproxen Tablets Using Gamma Scintigraphy | Ian R. Wilding, John G. Hardy, R. Andrew Sparrow, Stanley S. Davis and Paul B. Daly, et al. |
| 1442-1450 | Distribution and Elimination of the Glycosidase Inhibitors 1-Deoxymannojirimycin and N-Methyl-1-Deoxynojirimycin in the Rat in Vivo | Esther D. Faber, Roelof Oosting, Jacques J. Neefjes, Hidde L. Ploegh and Dirk K. F. Meijer |
| 1451-1455 | Pharmacokinetic Disposition of Multiple-Dose Transdermal Nicotine in Healthy Adult Smokers | Gregory M. Kochak, Jim X. Sun, R. Leslie Choi and Anthony J. Piraino |
| 1456-1459 | Age and the Pharmacokinetic-Pharmacodynamic Relationship of Phenobarbital in Rats: “Pseudo”-Longitudinal vs Cross-Sectional Study Design | Annemiek M. Stijnen, Meindert Danhof and Cornelius F. A. Bezooijen |
| 1460-1464 | Glutathione S-Transferase-Mediated Metabolism of Glyceryl Trinitrate in Subcellular Fractions of Bovine Coronary Arteries | David T.-W. Lau, Elaine K. Chan and Leslie Z. Benet |
| 1465-1473 | Kinetics and Mechanism of Degradation of Zileuton, a Potent 5-Lipoxygenase Inhibitor | Francisco J. Alvarez and Russell T. Slade |
| 1474-1479 | Synthesis of 2-(3-Substituted-1,2,4-oxadiazol-5-yl)-8-methyl-8-azabicyclo[3.2.1]octanes and 2α-(3-Substituted-1,2,4-oxadiazol-5-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-enes as Potential Muscarinic Agonists | David J. Triggle, Yong Wha Kwon, Philip Abraham, M. Abdur Rahman and F. Ivy Carroll |
| 1480-1486 | Relative Lipophilicities and Structural-Pharmacological Considerations of Various Angiotensin-Converting Enzyme (ACE) Inhibitors | Sunanda A. Ranadive, Andrew X. Chen and Abu T. M. Serajuddin |
| 1487-1492 | The Development of a Microwave Fluid-Bed Processor. I. Construction and Qualification of a Prototype Laboratory Unit | Michael K. Doelling, David M. Jones, Richard A. Smith and Robert A. Nash |
| 1493-1501 | The Development of a Microwave Fluid-Bed Processor. II. Drying Performance and Physical Characteristics of Typical Pharmaceutical Granulations | Michael K. Doelling and Robert A. Nash |
| 1502-1506 | In Vivo Evaluation of Biodegradable Progesterone Microspheres in Mares | Pramod K. Gupta, Rahul C. Mehta, Robert H. Douglas and Patrick P. Luca |
| 1507-1509 | Sustained Propranolol Delivery and Increased Oral Bioavailability in Dogs Given a Propranolol Laurate Salt | Brace J. Aungst and Munir A. Hussain |
| 1510-1514 | Relationship Between Polymer Viscosity and Drug Release from a Matrix System | Lucy Wan Sai Cheong, Paul Wan Sia Heng and Lee Fun Wong |
| 1515-1517 | Effect of Isoflurane Anesthesia on Antipyrine Pharmacokinetics in the Rat | Francis L. S. Tse, David F. Nickerson and Renee Aim |
| 1518-1520 | Employing lonization Behaviors to Resolve a Trace-Level Impurity: Determination of l,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedi-carboxylic Acid Di-2-[methyl-(phenylmethyl)amino]ethyl Ester in Nicardipine Drug Substance | Michael B. Maurin, Rodney D. Vickery, Philip Ma, Joseph Manalo and Munir A. Hussain |
| 1521-1523 | Degradation of Synthetic Salmon Calcitonin in Aqueous Solution | Kang Choon Lee, Yoon Joong Lee, Hyun Myo Song, Chang Ju Chun and Patrick P. Luca |
| 1524 | Association News and Announcements |
| 1525-1533 | Instrumentation of a High-Shear Mixer: Evaluation and Comparison of a New Capacitive Sensor, a Watt Meter, and a Strain-Gage Torque Sensor for Wet Granulation Monitoring | Vincent Corvari, William C. Fry, William L. Seibert and Larry Augsburger |
| 1534-1539 | Lymphatic Targeting of Polymeric Nanoparticles After Intraperitoneal Administration in Rats | Philippe Maincent, Pierre Thouvenot, Claude Amicabile, Maurice Hoffman and Jörg Kreuter, et al. |
| 1540-1545 | Hydrogels for Site-Specific Drug Delivery to the Colon: In Vitro and in Vivo Degradation | Helle Brøndsted and Jindřich Kopeček |
| 1546-1549 | The Influence of Liquid Crystalline Phases on Drug Percutaneous Absorption. I. Development of a Vehicle | James Swarbrick and James R. Siverly |
| 1550-1555 | The Influence of Liquid Crystalline Phases on Drug Percutaneous Absorption. II. Permeation Studies Through Excised Human Skin | James Swarbrick and James R. Siverly |
| 1556-1562 | Mixed Micelles as Proliposomes for the Solubilization of Teniposide | Hayat Alkan-Onyuksel and Kyonghee Son |
| 1563-1567 | Mucoadhesion of Copolymers and Mixtures Containing Polyacrylic Acid | Florence Thermes, Jeffrey Grove, Annouk Rozier, Bernard Plazonnet and Alain Constancis, et al. |
| 1568-1574 | Determination of Association Constants in Cyclodextrin/Drug Complexation Using the Scatchard Plot: Application to β-Cyclodextrin-Anilinonaphthalenesulfonates | Evangelos E. Sideris, Georgia N. Valsami, Michael A. Koupparis and Panayotis E. Macheras |
| 1575-1579 | Percutaneous Absorption Enhancement of Leuprolide | Mou-ying Fu Lu, Dennis Lee and G. Subba Rao |
| 1580-1586 | Permeability Characteristics of Various Intestinal Regions of Rabbit, Dog, and Monkey | Nancy Jezyk, Werner Rubas and George M. Grass |
| 1587-1591 | Influence of Permanent Cannulation of the Jugular Vein on Pharmacokinetics of Amoxycillin and Antipyrine in the Rat | Francisca Torres-Molina, Juan-Carlos Aristorena, Carmen Garcia-Carbonell, Luis Granero and Jesús Chesa-Jiménez, et al. |
| 1592-1598 | Validation of Different Microdialysis Methods for the Determination of Unbound Steady-State Concentrations of Theophylline in Blood and Brain Tissue | Per Sjöberg, Ing-Marie Olofsson and Thomas Lundqvist |
| 1599-1606 | Decreased Systemic Clearance of Diltiazem with Increased Hepatic Metabolism in Rats with Uranyl Nitrate-Induced Acute Renal Failure | Yong-Hee Lee, Min-Hwa Lee and Chang-Koo Shim |
| 1607-1611 | Kinetic Modeling of Ouabain Tissue Distribution Based on Slow and Saturable Binding to Na,K-ATPase | Hideyoshi Harashima, Michio Mamiya, Masayo Yamazaki, Yasufumi Sawada and Tatsuji Iga, et al. |
| 1612-1616 | The Bioinequivalence of Carbamazepine Tablets with a History of Clinical Failures | Marvin C. Meyer, Arthur B. Straughn, Eric J. Jarvi, George C. Wood and Francis R. Pelsor, et al. |
| 1617-1621 | Factors Determining the Intrinsic Lymphatic Partition Rate of Epitiostanol and Mepitiostane | Teruhisa Ichihashi, Yasushi Takagishi and Hideo Yamada |
| 1622-1628 | The Effect of Valproate on the Metabolism of Phenobarbital in the Rat | Gail D. Anderson and René H. Levy |
| 1629-1633 | Influence of Age and Gender on the Plasma Profiles of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitory Activity Following Multiple Doses of Lovastatin and Simvastatin | Haiyung Cheng, J. Douglas Rogers, Anna E. Sweany, Michael R. Dobrinska and Evan A. Stein, et al. |
| 1634-1639 | Use of Analytically Defined Estimates of Aerosol Respirable Fraction to Predict Lung Deposition Patterns | Ted B. Martonen, Ira Katz, Kristen Fults and Anthony J. Hickey |
| 1640-1643 | A High-Performance Liquid Chromatographic Method for the Quantitative Enantioselective Analysis of Mefloquine Stereoisomers | Yihong Qiu, Satoshi Kitamura and J. Keith Guillory |
| 1644-1647 | Mapping the Ligand Binding Pocket of the Human Muscarinic Cholinergic Receptor Hml: Contribution of Tyrosine-82 | Volkmar Drübbisch, Jelveh Lameh, Mohan Philip, Yogesh K. Sharma and Wolfgang Sadée |
| 1648-1653 | Effects of Diethyl Phthalate and Other Plasticizers on Laurate Hydroxylation in Rat Liver Microsomes | Richard T. Okita and Janice Rice Okita |
| 1654-1658 | Drug Delivery via Ion Exchange Across a Micromembrane | Dennis R. Jenke, Christopher D. Baron and Carol L. Mayers |
| 1659-1663 | Viscoelastic Properties of Polyacrylic Acid Gels in Mixed Solvents | James S. Chu, Danny M. Yu, Gordon L. Amidon, Norman D. Weiner and Arthur H. Goldberg |
| 1664-1667 | Formulation and Optimization of a Modified Microporous Cellulose Acetate Latex Coating for Osmotic Pumps | Leah E. Appel, James H. Clair and Gaylen M. Zentner |
| 1668-1670 | Chemoprevention of Chemically Induced Skin Tumor Development by Diallyl Sulfide and Diallyl Disulfide | Chandradhar Dwivedi, Stacie Rohlfs, Donnita Jarvis and Ferzaan N. Engineer |
| 1671-1672 | Cyclodextrin/Weak-Electrolyte Complexation: Interpretation and Estimation of Association Constants from Phase Solubility Diagrams | Fang-yu Liu, Dane O. Kildsig and Ashim K. Mitra |
| 1673-1676 | Chemical Stability of Ethyl Icosapentate Against Autoxidation. I. Effect of Temperature on Oxidation Kinetics | Reiko Teraoka, Makoto Otsuka and Yoshihisa Matsuda |
| 1677 | BOOK REVIEWS |
| 1677 | BOOK REVIEWS |
| 1678-1681 | Author Index to Volume 9 (1992) |
| 1682-1686 | Subject Index to Volume 9 (1992) |
| 1-7 | Behavior of Hygroscopic Pharmaceutical Aerosols and the Influence of Hydrophobic Additives | Anthony J. Hickey and Ted B. Martonen |
| 8-13 | Mean Residence Time of Oral Drugs Undergoing First-Pass and Linear Reversible Metabolism | Haiyung Cheng and William J. Jusko |
| 14-21 | Enantioselective Pharmacokinetics of dl-threo-Methylphenidate in Humans | Nuggehally R. Srinivas, John W. Hubbard, Elarien D. Korchinski and Kamal K. Midha |
| 22-27 | Pharmacokinetics of Stereomeric 1,4:3,6-Dianhydrohexitol Mononitrates in Rats | Tsang-Bin Tzeng and Ho-Leung Fung |
| 28-34 | Steady-State Bioavailability and Day-to-Day Variability of a Multiple-Unit (CR/ZOK) and a Single-Unit (OROS) Delivery System of Metoprolol After Once-Daily Dosing | Anders Sandberg, Bertil Abrahamsson, Agneta Svenheden, Bertil Olofsson and Robert Bergstrand |
| 35-43 | Time-Dependent Disposition of β-Naphthoflavone in the Rat | Adedayo Adedoyin, Leon Aarons and J. Brian Houston |
| 44-48 | Distribution of Tacrine Across the Blood–Brain Barrier in Awake, Freely Moving Rats Using in Vivo Microdialysis Sampling | Martin Telting-Diaz and Craig E. Lunte |
| 49-55 | Prinomide Tromethamine Pharmacokinetics: Mutually Dependent Saturable and Competitive Protein Binding Between Prinomide and Its Own Metabolite | Gregory M. Kochak, Sudhakar Pai, Robert Iannucci, Frank Honc and Deborah Kachmar, et al. |
| 56-60 | Column-Switching High-Performance Liquid Chromatographic Determination of a 2-Pyridinone-Based Human Immunodeficiency Virus Type 1 (HlV-l)-Specific Reverse Transcriptase Inhibitor in Human Plasma | Eric J. Woolf and Bogdan K. Matuszewski |
| 61-67 | Changes in Material Properties Accompanying the National Formulary (NF) Identity Test for Microcrystalline Cellulose | Harry G. Brittain, Geoffrey Lewen, Ann W. Newman, Kenneth Fiorelli and Susan Bogdanowich |
| 68-74 | Prodrugs of Peptides. 18. Synthesis and Evaluation of Various Esters of Desmopressin (dDAVP) | Anne H. Kahns, Anders Buur and Hans Bundgaard |
| 75-79 | The 3′-Keto–Diol Equilibrium of Trospectomycin Sulfate Bulk Drug and Freeze-Dried Formulation: Solid-State Carbon-13 Cross-Polarization Magic Angle Spinning (CP/MAS) and High-Resolution Carbon-13 Nuclear Magnetic Resonance (NMR) Spectroscopy Studies | Michael D. Likar, Richard J. Taylor, Paul E. Fagerness, Yukio Hiyama and Russell H. Robins |
| 80-87 | Design of New Formulations for Topical Ocular Administration: Polymeric Nanocapsules Containing Metipranolol | Cándida Losa, Laurent Marchal-Heussler, Francisco Orallo, José L. Vila Jato and Maria J. Alonso |
| 88-94 | Compression Characteristics of Granulated Materials. VII. The Effect of Intragranular Binder Distribution on the Compactibility of Some Lactose Granulations | Martin Wikberg and Göran Alderborn |
| 95-102 | Chemical Pathways of Peptide Degradation. IV. Pathways, Kinetics, and Mechanism of Degradation of an Aspartyl Residue in a Model Hexapeptide | Cecilia Oliyai and Ronald T. Borchardt |
| 103-108 | Stability of β-Galactosidase, a Model Protein Drug, Is Related to Water Mobility as Measured by 17O Nuclear Magnetic Resonance (NMR) | Sumie Yoshioka, Yukio Aso, Ken-ichi Izutsu and Tadao Terao |
| 109-112 | Controlled Delivery of Pilocarpine. 1. In Vitro Characterization of Gelfoam® Matrices | Sreekant R. Nadkarni and Samuel H. Yalkowsky |
| 113-118 | Comparison of the Permeability Characteristics of a Human Colonic Epithelial (Caco-2) Cell Line to Colon of Rabbit, Monkey, and Dog Intestine and Human Drug Absorption | Werner Rubas, Nancy Jezyk and George M. Grass |
| 119-125 | Sustained Bronchodilation with Isoproterenol Poly(Glycolide-co-Lactide) Microspheres | Yih-Loong Lai, Rahul C. Mehta, Arthur A. Thacker, Sun-Dong Yoo and Patrick J. McNamara, et al. |
| 126-129 | Human Transbuccal Absorption of Diclofenac Sodium from a Prototype Hydrogel Delivery Device | James Cassidy, Bret Berner, Keith Chan, Vivian John and Stephen Toon, et al. |
| 130-135 | Regional Gastrointestinal Absorption of the Beta-Blocker Pafenolol in the Rat and Intestinal Transit Rate Determined by Movement of 14C-Polyethylene Glycol (PEG) 4000 | Hans Lennernäs and Carl-Gunnar Regårdh |
| 136-140 | Relationship Among Physicochemical Properties, Skin Permeability, and Topical Activity of the Racemic Compound and Pure Enantiomers of a New Antifungal | Lorraine Wearley, Barry Antonacci, Anthony Cacciapuoti, Seb Assenza and Imtiaz Chaudry, et al. |
| 141-146 | Acacia-Gelatin Microencapsulated Liposomes: Preparation, Stability, and Release of Acetylsalicylic Acid | Cunji Dong and James A. Rogers |
| 147-151 | Comparison of the Leakage of Carboxyfluorescein from Symmetric-and Asymmetric-Acyl Chain Phosphatidylcholine Vesicles | Timothy S. Wiedmann, Amir Salmon and Walter R. Perkins |
| 152-155 | Effect of Humidity and Occlusion on the Percutaneous Absorption of Parathion in Vitro | Shao-Kaung Chang and Jim E. Riviere |
| 156-159 | Kinetics of Aspirin Hydrolysis and Stabilization in the Presence of 2-Hydroxypropyl-β-Cyclodextrin | Somesh Choudhury and Ashim K. Mitra |
| 160-161 | Reviewers for Pharmaceutical Research (October 1, 1991-October 19, 1992) |
| 162 | European Reviewers for Pharmaceutical Research (October 1991-October 1992) |
| 162 | Japanese Reviewers for Pharmaceutical Research (May 1992-September 1992) |
| 163 | Association News and Announcements |
| 164 | HANS BUNDGAARD IN MEMORIAM | Henning G. Kristensen and Douwe D. Breimer |
| 165-170 | Introduction to Backpropagation Neural Network Computation | Randall J. Erb |
| 171-186 | Applications of Capillary Electrophoresis in Pharmaceutical Analysis | Shelley R. Rabel and John F. Stobaugh |
| 187-196 | Upper Gastrointestinal pH in Seventy-Nine Healthy, Elderly, North American Men and Women | Tanya L. Russell, Rosemary R. Berardi, Jeffrey L. Barnett, Lambros C. Dermentzoglou and Kathleen M. Jarvenpaa, et al. |
| 197-203 | Solid-State Nuclear Magnetic Resonance (NMR) Spectra of Pharmaceutical Dosage Forms | Patricia J. Saindon, Nina S. Cauchon, Paul A. Sutton, C.-j. Chang and Garnet E. Peck, et al. |
| 204-207 | A Fluorescence Quenching Method for Estimating Chelating Groups in Chelate-Conjugated Macromolecules | Wanlong Ma, Karl J. Hwang and Vincent H. L. Lee |
| 208-213 | Preparation of Heptakis(2,6-di-O-ethyl)-β-cyclodextrin and Its Nuclear Magnetic Resonance Spectroscopic Characterization | Fumitoshi Hirayama, Masahiko Kurihara, Yasuhide Horiuchi, Tadanobu Utsuki and Kaneto Uekama, et al. |
| 214-219 | Antitumor Agents. 125. New 4β-Benzoylamino Derivatives of 4′-O-Demethyl-4-desoxypodophyllotoxin and 4β-Benzoyl Derivatives of 4′-O-Demethylpodophyllotoxin as Potent Inhibitors of Human DNA Topoisomerase II | Xiao-Ming Zhou, Zhe-Qing Wang, Hong-Xing Chen, Yung-Chi Cheng and Kuo-Hsiung Lee |
| 220-222 | The Effect of Phenol on the Electrolyte Flocculation of Certain Polymeric Dispersions to Thixotropic Gels | Roland S. Okor |
| 223-227 | The Pharmacokinetics and Absorption of Recombinant Human Relaxin in Nonpregnant Rabbits and Rhesus Monkeys After Intravenous and Intravaginal Administration | Sharon A. Chen, Baron Reed, Tue Nguyen, Natalie Gaylord and Gene B. Fuller, et al. |
| 228-232 | Pulmonary Delivery of Free and Liposomal Insulin | Fang-yu Liu, Zezhi Shao, Dane O. Kildsig and Ashim K. Mitra |
| 233-238 | An in Vitro/in Vivo Correlation for the Disintegration and Onset of Drug Release from Enteric-Coated Pellets | James P. Ebel, Michael Jay and Robert M. Beihn |
| 239-242 | Correlation Between the Disintegration Time and the Bioavailability of Vitamin C Tablets | Hemmige N. Bhagavan and Brigitte I. Wolkoff |
| 243-251 | Differential Effects of Anionic, Cationic, Nonionic, and Physiologic Surfactants on the Dissociation, α-Chymotryptic Degradation, and Enteral Absorption of Insulin Hexamers | Zezhi Shao, Yuping Li, Ramesh Krishnamoorthy, Todd Chermak and Ashim K. Mitra |
| 252-257 | Use of the Gamma-Ray Perturbed Angular Correlation (PAC) Technique for Monitoring Liposomal Phospholipid Bilayer Integrity | Wanlong Ma, Karl J. Hwang and Vincent H. L. Lee |
| 258-263 | In Vitro Evaluation of Calcium Pectinate: A Potential Colon-Specific Drug Delivery Carrier | Abraham Rubinstein, Raphael Radai, Miriam Ezra, Seema Pathak and J. Stefan Rokem |
| 264-270 | Estimating the Fraction Dose Absorbed from Suspensions of Poorly Soluble Compounds in Humans: A Mathematical Model | Doo-Man Oh, Rane L. Curl and Gordon L. Amidon |
| 271-275 | Mass Balance Approaches for Estimating the Intestinal Absorption and Metabolism of Peptides and Analogues: Theoretical Development and Applications | Patrick J. Sinko, Glen D. Leesman and Gordon L. Amidon |
| 276-281 | A Saturable Transport Mechanism in the Intestinal Absorption of Gabapentin Is the Underlying Cause of the Lack of Proportionality Between Increasing Dose and Drug Levels in Plasma | Barbra H. Stewart, Alan R. Kugler, Paul R. Thompson and Howard N. Bockbrader |
| 282-288 | Biotin Uptake and Transport Across Bovine Brain Microvessel Endothelial Cell Monolayers | Fenglin Shi, Carole Bailey, A. Waseem Malick and Kenneth L. Audus |
| 289-293 | Influence of Dose Range on Degree of Nonlinearity Detected in Dose-Proportionality Studies for Drugs with Saturable Elimination: Single-Dose and Steady-State Studies | Theresa A. Shepard, Nicholas Lordi and Philip E. Sparrow |
| 294-299 | Selective Effect of Adjuvant Arthritis on the Disposition of Propranolol Enantiomers in Rats Detected Using a Stereospecific HPLC Assay | Micheline Piquette-Miller and Fakhreddin Jamali |
| 300-304 | Effect of Plasma Protein Binding on Kinetics of Capillary Uptake and Efflux | Denis J. Morgan and Jiu Li Huang |
| 305-308 | A Spectrophotometric Modification of the Winkler Method for Measurement of Dissolved Oxygen | Francis J. Nowaczyk Jr, Roger L. Schnaare, Clyde M. Ofner III and Rodney J. Wigent |
| 309-312 | Physical Chemical Properties of Alpha Styryl Carbinol Antifungal Agents | Michael B. Maurin, William J. Addicks, Susan M. Rowe and Robert Hogan |
| 313-316 | Scaleup of Immediate Release Oral Solid Dosage Forms | J. P. Skelly, G. A. Van Buskirk, D. R. Savello, G. L. Amidon and H. M. Arbit, et al. |
| 317-327 | Solid-State Nuclear Magnetic Resonance Spectroscopy: Theory and Pharmaceutical Applications | David E. Bugay |
| 328-334 | Solid-State Diode Laser-Induced Fluorescence Detection in High-Performance Liquid Chromatography | Sadayappan V. Rahavendran and H. Thomas Karnes |
| 335-342 | In Vivo Microdialysis Sampling in the Bile, Blood, and Liver of Rats to Study the Disposition of Phenol | Dennis O. Scott and Craig E. Lunte |
| 343-350 | Antitumor Agents 126. Novel 4β-Substituted Anilino Derivatives of 3′,4′ -O, O-Didemethylpodophyllotoxin as Potent Inhibitors of Human DNA Topoisomerase II | Zhe-Qing Wang, Ya-Ching Shen, Hong-Xing Chen, Jang-Yang Chang and Xin Guo, et al. |
| 351-355 | Low-Substituted Hydroxypropylcellulose as a Sustained-Drug Release Matrix Base or Disintegrant Depending on Its Particle Size and Loading in Formulation | Yoshiaki Kawashima, Hirofumi Takeuchi, Tomoaki Hino, Toshiyuki Niwa and Tzu-Lang Lin, et al. |
| 356-361 | Drug Release Mechanism from a Microcrystalline Cellulose Pellet System | Robert E. O'Connor and Joseph B. Schwartz |
| 362-368 | The Preparation and Characterization of Poly(lactide-co-glycolide) Microparticles. II. The Entrapment of a Model Protein Using a (Water-in-Oil)-in-Water Emulsion Solvent Evaporation Technique | Hayley Jeffery, Stanley S. Davis and Derek T. O'Hagan |
| 369-380 | Tissue Response to Bioerodible, Subcutaneous Drug Implants: A Possible Determinant of Drug Absorption Kinetics | F. D. Anderson, D. F. Archer, S. M. Harman, R. J. Leonard and W. H. Wilborn |
| 381-385 | Electrochemical Characterization of Human Skin by Impedance Spectroscopy: The Effect of Penetration Enhancers | Kyösti Kontturi, Lasse Murtomäki, Jouni Hirvonen, Petteri Paronen and Arto Urtti |
| 386-390 | Poly(ε-Caprolactone) Nanocapsules in Carteolol Ophthalmic Delivery | Laurent Marchal-Heussler, Daniel Sirbat, Maurice Hoffman and Philippe Maincent |
| 391-399 | Polyanhydride Mierospheres that Display Near-Constant Release of Water-Soluble Model Drug Compounds | Yasuhiko Tabata and Robert Langer |
| 400-404 | Peptide Carrier-Mediated Transport in Intestinal Brush Border Membrane Vesicles of Rats and Rabbits: Cephradine Uptake and Inhibition | Hiroaki Yuasa, Gordon L. Amidon and David Fleisher |
| 405-410 | An Investigation into the Mechanical and Transport Properties of Aqueous Latex Films: A New Hypothesis for the Film-Forming Mechanism of Aqueous Dispersion System | Jian-Hwa Guo, Richard E. Robertson and Gordon L. Amidon |
| 411-417 | Viscoelasticity of Anionic Polymers and Their Mucociliary Transport on the Frog Palate | Shun Y. Lin, Gordon L. Amidon, Norman D. Weiner and Arthur H. Goldberg |
| 418-422 | Disposition of Azole Antifungal Agents. I. Nonlinearities in Ketoconazole Clearance and Binding in Rat Liver | Diane Matthew, Beverley Brennan, Katayoun Zomorodi and J. Brian Houston |
| 423-426 | Interaction of Nucleoside Analogues with the Sodium–Nucleoside Transport System in Brush Border Membrane Vesicles from Human Kidney | Claire M. Brett, Carla B. Washington, Ronda J. Ott, Marcelo M. Gutierrez and Kathleen M. Giacomini |
| 427-433 | Pharmacokinetics of a Novel Antiarrhythmic Drug, Actisomide | Chyung S. Cook, Leonard F. Rozek, James Stolzenbach, Steve Anderson and Grant L. Schoenhard, et al. |
| 434-440 | Comparison of the Hepatic Uptake Clearances of Fifteen Drugs with a Wide Range of Membrane Permeabilities in Isolated Rat Hepatocytes and Perfused Rat Livers | Seiji Miyauchi, Yasufumi Sawada, Tatsuji Iga, Manabu Hanano and Yuichi Sugiyama |
| 441-444 | Rapid Determination of Methadone in Plasma, Cerebrospinal Fluid, and Urine by Gas Chromatography and Its Application to Routine Drug Monitoring | Norbert Schmidt, Reinhard Sittl, Kay Brune and Gerd Geisslinger |
| 445-448 | Stabilization of Oxygen-Sensitive Formulations via a Secondary Oxygen Scavenger | Carol L. Mayers and Dennis R. Jenke |
| 449-453 | Three Approaches to the Analysis of Trace Formaldehyde in Bulk and Dosage Form Pharmaceuticals | Gerald J. Manius, Lan-Fun Li Wen and David Palling |
| 454-456 | Axial Ratio Measurements for Early Detection of Crystal Growth in Suspension-Type Metered Dose Inhalers | Elaine M. Phillips, Peter R. Byron and Richard N. Dalby |
| 457-460 | Loading of Bovine Serum Albumin into Hydrogels by an Electrophoretic Process and Its Potential Application to Protein Drugs | Waleed S. W. Shalaby, Anna A. Abdallah, Haesun Park and Kinam Park |
| 461-465 | Molecular Cloning of Two cDNAs Encoding the Mouse Bilirubin/Phenol Family of UDP-Glucuronosyltransferases (mUGTBr/p) | Ah-Ng Tony Kong, Meihui Ma, Deling Tao and Linding Yang |
| 466-469 | Feasibility of Developing a Neural Network for Prediction of Human Pharmacokinetic Parameters from Animal Data | Ajaz S. Hussain, Robert D. Johnson, Nimish N. Vachharajani and Wolfgang A. Ritschel |
| 470-472 | Formation of a Chromophoric Complex Between Alendronate and Copper(II) Ions | Dražen Ostović, Christine Stelmach and Becky Hulshizer |
| 473 | BOOK REVIEWS |
| 473 | BOOK REVIEWS |
| 474 | BOOK REVIEWS |
| 475-486 | Strategies for Indirect Computer-Aided Drug Design | Gilda H. Loew, Hugo O. Villar and Ibon Alkorta |
| 487-496 | Controlled Delivery Systems for Proteins Using Polyanhydride Microspheres | Yasuhiko Tabata, Sunitha Gutta and Robert Langer |
| 497-506 | A New Method for Estimating Dermal Absorption from Chemical Exposure. 1. General Approach | Robert L. Cleek and Annette L. Bunge |
| 507-514 | Immunotargeting of Liposomes Containing Lipophilic Antitumor Prodrugs | Atsuhide Mori, Stephen J. Kennel and Leaf Huang |
| 515-520 | Synthesis and Testing of New Antileukemic Schiff Bases of N-Hydroxy-N′ - Aminoguanidine Against CCRF-CEM/0 Human Leukemia Cells in Vitro and Synergism Studies with Cytarabine (Ara-C) | Phanesh B. Koneru, Eric J. Lien and Vassilios I. Avramis |
| 521-524 | Taxol and Related Taxanes. I. Taxanes of Taxus brevifolia Bark | Koppaka V. Rao |
| 525-534 | Aqueous Ethylcellulose Dispersion of Ethylcellulose. I. Evaluation of Coating Process Variables | Nilesh H. Parikh, Stuart C. Porter and Bhagwan D. Rohera |
| 535-541 | A Method for the Early Evaluation of the Effects of Storage and Additives on the Stability of Parenteral Fat Emulsions | Jianmin Li, Karin D. Caldwell and Bradley D. Anderson |
| 542-548 | The Influence of Thermal Treatment on the Physical-Mechanical and Dissolution Properties of Tablets Containing Poly(DL-Lactic Acid) | Marcelo O. Omelczuk and James W. McGinity |
| 549-552 | Uptake of Phosphatidylserine Liposomes by Rat Peyer's Patches Following Intraluminal Administration | Hitoshi Tomizawa, Yukihiko Aramaki, Yoshimine Fujii, Toshifumi Kara and Norio Suzuki, et al. |
| 553-561 | In Vitro Nasal Transport Across Ovine Mucosa: Effects of Ammonium Glycyrrhizinate on Electrical Properties and Permeability of Growth Hormone Releasing Peptide, Mannitol, and Lucifer Yellow | Patricia M. Reardon, Caroline H. Gochoco, Kenneth L. Audus, Glynn Wilson and Philip L. Smith |
| 562-566 | Development of Activity Assays for High-Volume Evaluation of Human Immunodeficiency Virus (HIV) Protease Inhibitors in Rat Serum: Results with Ditekiren | Karen F. Wilkinson, Bob D. Rush, Satish K. Sharma, David B. Evans and Mary J. Ruwart, et al. |
| 567-572 | Pharmacokinetics of Recombinant Human Interferon-βser in Healthy Volunteers and Its Effect on Serum Neopterin | Janie Chiang, Carol A. Gloff, Carl N. Yoshizawa and Gary J. Williams |
| 573-576 | Decreased Cellular Toxicity of Neomycin in a Clonal Cell Line Isolated from LLC-PK1 | Ryohei Hori, Masahiro Okuda, Yoshiko Ohishi, Masato Yasuhara and Ken-ichi Inui, et al. |
| 577-582 | Physicochemical Stability of Phenobarbital Polymorphs at Various Levels of Humidity and Temperature | Makoto Otsuka, Mika Onoe and Yoshihisa Matsuda |
| 583-587 | An in Vitro Study of Diamorphine Permeation Through Premature Human Neonatal Skin | David A. Barrett, Nicholas Rutter and Stanley S. Davis |
| 588-592 | In Vivo/in Vitro Correlation of Experimental Sustained-Release Theophylline Formulations | Kah-Hay Yuen, Arvind A. Desmukh and John M. Newton |
| 593-597 | Comparison of the Pharmacokinetics and Pharmacodynamics of the Aldose Reductase Inhibitors, AL03152 (RS), AL03802 (R), and AL03803 (S) | Young Han Park, Philip R. Mayer, Ronnie Barker, Mark DuPriest and Brenda W. Griffin, et al. |
| 598-602 | Pharmacokinetic Monitoring in Subcutaneous Tissue Using in Vivo Capillary Ultrafiltration Probes | Michael C. Linhares and Peter T. Kissinger |
| 603-605 | Clinical Pharmacokinetics and Relative Bioavailability of Oral Procaterol | Michael A. Eldon, Michele M. Battle, Michael J. Coon, Gerald D. Nordblom and Allen J. Sedman, et al. |
| 606-610 | Distinction Between the Depletion of Opsonins and the Saturation of Uptake in the Dose-Dependent Hepatic Uptake of Liposomes | Hideyoshi Harashima, Kazuya Sakata and Hiroshi Kiwada |
| 611-615 | Formycin B Elimination from the Cerebrospinal Fluid of the Rat | Xiaochun Wu, Andrew C. Hui and Kathleen M. Giacomini |
| 616-620 | The Determination of Diffusion Coefficients in Semisolids by Fourier Transform Infrared (FT-IR) Spectroscopy | Dale Eric Wurster, Varaporn Buraphacheep and Jatin M. Patel |
| 621-626 | Optimization of Conditions for Preparing 2- to 5-Micron-Range Gelatin Microparticles by Using Chilled Dehydration Agents | Levent Öner and Michael J. Groves |
| 627-630 | Molecular Cloning of the Alcohol/Hydroxysteroid Form (mSTa1) of Sulfotransferase from Mouse Liver | Ah-Ng Tony Kong, Deling Tao, Meihui Ma and Linding Yang |
| 631-634 | Micellar Solubilization of Clofazimine Analogues in Aqueous Solutions of Ionic and Nonionic Surfactants | Khairi M. S. Fahelelbom, Richard F. Timoney and Owen I. Corrigan |
| 635 | BOOK REVIEWS |
| 635-637 | Letters to the Editor | Russell O. Potts, Richard H. Guy, Philip S. Burton, Norman F. H. Ho and Robert A. Conradi, et al. |
| 638 | Association News and Announcements |
| 639-648 | Hydrolysis of Carbonates, Thiocarbonates, Carbamates, and Carboxylic Esters of α-Naphthol, β-Naphthol, and p-Nitrophenol by Human, Rat, and Mouse Liver Carboxylesterases | Tien L. Huang, András Székács, Tamon Uematsu, Eiichi Kuwano and Andrew Parkinson, et al. |
| 649-659 | Formulation Design of Acidic Fibroblast Growth Factor | P. K. Tsai, David B. Volkin, Jonathan M. Dabora, Karen C. Thompson and Mark W. Bruner, et al. |
| 660-661 | Enkephalin Antisense Peptides: Design, Synthesis, and Biological Activity | Pravin K. Misra, Wahajul Haq, Seturam B. Katti, Krishna B. Mathur and Ram Raghubir, et al. |
| 662-666 | Decomposition of Arteether in Simulated Stomach Acid Yielding Compounds Retaining Antimalarial Activity | John K. Baker, James D. McChesney and Hsien Tao Chi |
| 667-673 | Thyrotropin-Releasing Hormone (TRH) Uptake in Intestinal Brush-Border Membrane Vesicles: Comparison with Proton-Coupled Dipeptide and Na+-Coupled Glucose Transport | David T. Thwaites, Nicholas L. Simmons and Barry H. Hirst |
| 674-681 | Passive Transepithelial Absorption of Thyrotropin-Releasing Hormone (TRH) via a Paracellular Route in Cultured Intestinal and Renal Epithelial Cell Lines | David T. Thwaites, Barry H. Hirst and Nicholas L. Simmons |
| 682-686 | Nasal Insulin Delivery with Dimethyl-β-Cyclodextrin as an Absorption Enhancer in Rabbits: Powder More Effective than Liquid Formulations | Nicolaas G. M. Schipper, Stefan G. Romeijn, J. Coos Verhoef and Frans W. H. M. Merkus |
| 687-691 | Aggregates Formed During Storage of β-Galactosidase in Solution and in the Freeze-Dried State | Sumie Yoshioka, Yukio Aso, Ken-ichi Izutsu and Tadao Terao |
| 692-696 | Development of a Sensitive Radioimmunoassay for Fab Fragments: Application to Fab Pharmacokinetics in Humans | Corinne Vo Thanh-Barthet, Michel Urtizberea, Alain E. Sabouraud, Nathalie J. Cano and Jean-Michel G. Scherrmann |
| 697-702 | Hydrogel-Based lontotherapeutic Delivery Devices for Transdermal Delivery of Peptide/Protein Drugs | Ajay K. Banga and Yie W. Chien |
| 703-708 | Prolongation of the Circulation Time of Doxorubicin Encapsulated in Liposomes Containing a Polyethylene Glycol-Derivatized Phospholipid: Pharmacokinetic Studies in Rodents and Dogs | Alberto A. Gabizon, Yechezkel Barenholz and Meir Bialer |
| 709-714 | Absorption, Gastrointestinal Transit, and Tablet Erosion of Felodipine Extended-Release (ER) Tablets | Bertil Abrahamsson, Magne Alpsten, Morgan Hugosson, Ulf E. Jonsson and Mats Sundgren, et al. |
| 715-721 | Targeted Delivery of a Heme Oxygenase Inhibitor with a Lyophilized Liposomal Tin Mesoporphyrin Formulation | John B. Cannon, Carrie Martin, George S. Drummond and Attallah Kappas |
| 722-726 | The Effect of Meal Composition on the Gastrocolonic Response: Implications for Drug Delivery to the Colon | Jennifer M. C. Price, Stanley S. Davis, Robert A. Sparrow and Ian R. Wilding |
| 727-731 | Dose-Dependent Intestinal Absorption and Significant Intestinal Excretion (Exsorption) of the β-Blocker Pafenolol in the Rat | Hans Lennernäs and Carl-Gunnar Regårdh |
| 732-736 | The Development of a Predictive Method for the Estimation of Flux Through Polydimethylsiloxane Membranes. III. Application to a Series of Substituted Pyridines | Meng-wei Hu and Lloyd E. Matheson |
| 737-742 | Effects of Solute Characteristics and Concentration on a Lyotropic Liquid Crystal: Solute-Induced Phase Change | Hussein G. Ibrahim, El-Sayed Sallam, Mahmoud Takieddin and Mayssoun Habboub |
| 743-749 | Drug Absorption Limited by P-Glycoprotein-Mediated Secretory Drug Transport in Human Intestinal Epithelial Caco-2 Cell Layers | Janice Hunter, Barry H. Hirst and Nicholas L. Simmons |
| 750-756 | Influence of Poly(DL-Lactide) Nanocapsules on the Biliary Clearance and Enterohepatic Circulation of Indomethacin in the Rabbit | Fawaz Fawaz, François Bonini, Michel Guyot, Anne-Marie Lagueny and Hatem Fessi, et al. |
| 757-762 | Pharmacokinetic Analysis of an Oral Sustained-Release Diltiazem Preparation Using Multifraction Absorption Models | Kazuo Murata and Kazuo Noda |
| 763-770 | Absorption of 2′, 3′-Dideoxyinosine from Lower Gastrointestinal Tract in Rats and Kinetic Evidence of Different Absorption Rates in Colon and Rectum | Steven L. Bramer, M. Guillaume Wientjes and Jessie L.-S. Au |
| 771-773 | Simplified Synthesis of Mono(4-aminophenyl)-3′ -Thymidilic Acid Ester Used as Thymidine Kinase Specific Ligand for Affinity Chromatography | Kurt Eger, Eberhard Klünder, Rainer A. Beck and Ulrich Schloz |
| 774-776 | The Influence of Free Fatty Acid Formation on the pH of Phospholipid-Stabilized Triglyceride Emulsions | Clifford J. Herman and Michael J. Groves |
| 777-782 | Theoretical Considerations for the Design and Development of a Drug: Influence of Pharmacokinetics and Dosage Regimen on Receptor Interactions | Joyce Mordenti and Aldo Rescigno |
| 783-790 | Interferon-γ in Starch Microparticles: Nitric Oxide-Generating Activity in Vitro and Antileishmanial Effect in Mice | Lena Degling, Peter Stjärnkvist and Ingvar Sjöholm |
| 791-799 | Molecular Mobility in Mixtures of Absorbed Water and Solid Poly(vinylpyrrolidone) | Cynthia A. Oksanen and George Zografi |
| 800-809 | Mechanism and Kinetics of Metal Ion-Mediated Degradation of Fosinopril Sodium | Ajit B. Thakur, Kenneth Morris, John A. Grosso, Kenneth Himes and John K. Thottathil, et al. |
| 810-815 | Tensile Properties of Free Films Cast from Aqueous Ethylcellulose Dispersions | Nilesh H. Parikh, Stuart C. Porter and Bhagwan D. Rohera |
| 816-822 | Calibration of a Compaction Simulator for the Measurement of Tablet Thickness During Compression | Lovelace E. Holman and Keith Marshall |
| 823-827 | Disposition Characteristics of Protein Drugs in the Perfused Rat Kidney | Kiyoshi Mihara, Takami Hojo, Makoto Fujikawa, Yoshinobu Takakura and Hitoshi Sezaki, et al. |
| 828-833 | A New Route of Drug Administration: Intrauterine Delivery of Insulin and Calcitonin | Gershon Golomb, Avi Avramoff and Amnon Hoffman |
| 834-838 | The Pharmacokinetics of Recombinant Human Relaxin in Nonpregnant Women After Intravenous, Intravaginal, and Intracervical Administration | Sharon A. Chen, Andrew J. Perlman, Noreen Spanski, C. Matthew Peterson and Steven W. Sanders, et al. |
| 839-842 | The Development of a Predictive Method for the Estimation of Flux Through Polydimethylsiloxane Membranes. IV. Application to a Series of Substituted Quinolines | Lloyd E. Matheson and Meng-wei Hu |
| 843-852 | A Drug Absorption Model Based on the Mucus Layer Producing Human Intestinal Goblet Cell Line HT29-H | Agneta Wikman, Johan Karlsson, Ingemar Carlstedt and Per Artursson |
| 853-856 | In Vitro/in Vivo Correlation of the Bioadhesive Properties of a Buccal Bioadhesive Miconazole Slow-Release Tablet | Stefan Bouckaert, Remain A. Lefebvre and Jean-Paul Remon |
| 857-864 | Sodium Caprate Elicits Dilatations in Human Intestinal Tight Junctions and Enhances Drug Absorption by the Paracellular Route | Eva Karin Anderberg, Tuulikki Lindmark and Per Artursson |
| 865-870 | Comparison of the Mechanism of Dissolution of Hydrocortisone in Simple and Mixed Micelle Systems | Lori J. Naylor, Vassiliki Bakatselou and Jennifer B. Dressman |
| 871-878 | Deposition Patterns of Aerosolized Drugs Within Human Lungs: Effects of Ventilatory Parameters | Ted B. Martonen and Ira M. Katz |
| 879-883 | Evidence for an Interaction Between the β-Blocker Pafenolol and Bile Salts in the Intestinal Lumen of the Rat Leading to Dose-Dependent Oral Absorption and Double Peaks in the Plasma Concentration–Time Profile | Hans Lennernäs and Carl-Gunnar Regårdh |
| 884-888 | Influence of Anesthetic Regimens on Intestinal Absorption in Rats | Hiroaki Yuasa, Kenji Matsuda and Jun Watanabe |
| 889-894 | Interpretation and Utilization of Effect and Concentration Data Collected in an in Vivo Pharmacokinetic and in Vitro Pharmacodynamic Study | Suneel K. Gupta, Stephen S. Hwang, Leslie Z. Benet and Mark Gumbleton |
| 895-899 | Analysis of Micelle Formation of an Adriamycin-Conjugated Poly(Ethylene Glycol)–Poly(Aspartic Acid) Block Copolymer by Gel Permeation Chromatography | Masayuki Yokoyama, Takumichi Sugiyama, Teruo Okano, Yasuhisa Sakurai and Mayumi Naito, et al. |
| 900-904 | A Spectroscopic Investigation of Losartan Polymorphs | Krishnaswamy Raghavan, Anil Dwivedi, G. Creston Campbell Jr, Eric Johnston and Dorothy Levorse, et al. |
| 905-912 | Structure of 3-Acetyl-5-fluorouracil (5-FU): Implication for Its Rearrangements During Hydrolysis and upon Heating | Howard D. Beall, Richard J. Prankerd, Louis J. Todaro and Kenneth B. Sloan |
| 913-917 | The Liposome Partitioning System for Correlating Biological Activities of Imidazolidine Derivatives | James A. Rogers and Young W. Choi |
| 918-923 | A Structured–Activity Relationship Study of Batracylin Analogues | Yilin Luo, Yun-Feng Ren, Ting-Chao Chou, Allan Y. Chen and Chiang Yu, et al. |
| 924-926 | Intranasal Delivery of the Bisphosphonate Alendronate in the Rat and Dog | Steven C. Sutton, Karen Engle and Joseph A. Fix |
| 927-929 | Modification of the Dialysis Membrane Method for Drug Release from Suppositories | Masaru Yamazaki, Soichi Itoh, Naomi Sasaki, Kazuhisa Tanabe and Mitsuru Uchiyama |
| 930-931 | Can We Assign an Upper Limit to Skin Permeability? | Gerald B. Kasting and Peter J. Robinson |
| 932 | ERRATUM |
| 933-944 | Degradation Pathways for Recombinant Human Macrophage Colony-Stimulating Factor in Aqueous Solution | Jay A. Schrier, Richard A. Kenley, Rick Williams, Robert J. Corcoran and Yangkil Kim, et al. |
| 945-953 | Determinants of Release Rate of Tetanus Vaccine from Polyester Microspheres | Maria J. Alonso, Smadar Cohen, Tae G. Park, Rajesh K. Gupta and George R. Siber, et al. |
| 954-962 | Techniques for Assessing the Effects of Pharmaceutical Excipients on the Aggregation of Porcine Growth Hormone | Susan A. Charman, Kaye L. Mason and William N. Charman |
| 963-969 | Low Molecular Weight Proteins as Carriers for Renal Drug Targeting: Naproxen Coupled to Lysozyme via the Spacer L-Lactic Acid | Eric J. F. Franssen, Frits Moolenaar, Dick de Zeeuw and Dirk K. F. Meijer |
| 970-974 | Biodistribution of Micelle-Forming Polymer–Drug Conjugates | Glen S. Kwon, Masayuki Yokoyama, Teruo Okano, Yasuhisa Sakurai and Kazunori Kataoka |
| 975-979 | Identification of an Escherichia coli Protein Impurity in Preparations of a Recombinant Pharmaceutical | Donald O. O'Keefe, Peter DePhillips and Mark L. Will |
| 980-985 | Swelling and Dissolution Kinetics During Peptide Release from Erodible Anionic Gel Beads | Ping I. Lee |
| 986-990 | Effect of Receiver Fluid pH on in Vitro Skin Flux of Weakly lonizable Drugs | Jim H. Kou, Samir D. Roy, Jie Du and Jean Fujiki |
| 991-997 | Regulation of Tight Junction Permeability by Calcium Mediators and Cell Cytoskeleton in Rabbit Tracheal Epithelium | Meenakshi Bhat, David Toledo-Velasquez, LiYing Wang, Carl J. Malanga and Joseph K. H. Ma, et al. |
| 998-1004 | Characterization of Antacid Compounds Containing Both Aluminum and Magnesium. I. Crystalline Powders | Cheryl L. Peterson, Darold L. Perry, Hamid Masood, Huahua Lin and Joe L. White, et al. |
| 1005-1007 | Characterization of Antacid Compounds Containing Both Aluminum and Magnesium. II. Codried Powders | Cheryl L. Peterson, Darold L. Perry, Hamid Masood, Joe L. White and Stanley L. Hem, et al. |
| 1008-1014 | Growth and Morphology of L-Alanine Crystals: Influence of Additive Adsorption | David Lechuga-Ballesteros and Nair Rodriguez-Hornedo |
| 1015-1019 | ε-Aminocaproic Acid Esters as Transdermal Penetration Enhancing Agents | Pavel Doležal, Alexandr Hrabálek and Vladimir Semecký |
| 1020-1026 | In Vivo Validation of the Release Rate and Palatability of Remoxipride-Modified Release Suspension | Rolf Sjöqvist, Christina Graffner, Inger Ekman, Wendy Sinclair and Jonathan P. Woods |
| 1027-1030 | Effect of Sodium Acid Pyrophosphate on Ranitidine Bioavailability and Gastrointestinal Transit Time | Kevin M. Koch, Alan F. Parr, Julie J. Tomlinson, Erik P. Sandefer and George A. Digenis, et al. |
| 1031-1036 | The Impact of Lag Time on the Estimation of Pharmacokinetic Parameters. I. One-Compartment Open Model | Nadhamuni G. Nerella, Lawrence H. Block and Patrick K. Noonan |
| 1037-1045 | The Effect of Gastric pH on the Absorption of Controlled-Release Theophylline Dosage Forms in Humans | Marvin C. Meyer, Arthur B. Straughn, Eric J. Jarvi, George C. Wood and Vijaykumar I. Vashi, et al. |
| 1046-1051 | Increased Sensitivity to the Anticonvulsant Effect of Valproate in Aging BN/BiRij Rats | Annemiek M. Stijnen, Suzanne Hovinga, Mariska W. E. Langemeijer, Arendien Hoogerkamp and Cornells F. A. van Bezooijen, et al. |
| 1052-1058 | Application of the Periodic Bond Chain (PBC) Theory and Attachment Energy Consideration to Derive the Crystal Morphology of Hexamethylmelamine | Piet Hartman and Hak-Kim Chan |
| 1059-1065 | Albumin Microspheres as a Drug Delivery System: Relation Among Turbidity Ratio, Degree of Cross-linking, and Drug Release | Orapin P. Rubino, Richard Kowalsky and James Swarbrick |
| 1066-1070 | Zero-Order Drug Release from Hydrocolloid Matrices | Jörn E. Möckel and Bernhard C. Lippold |
| 1071-1075 | Solid-State Emulsions: The Effects of Process and Storage Conditions | Merrick L. Shively and Scott Myers |
| 1076-1082 | Solubilization and Stabilization of an Anti-HIV Thiocarbamate, NSC 629243, for Parenteral Delivery, Using Extemporaneous Emulsions | Robert G. Strickley and Bradley D. Anderson |
| 1083-1086 | Intranasal Absorption of a Kappa Agonist Analgesic | Munir A. Hussain, William K. Schmidt and John D. Buehler |
| 1087-1089 | Controlled Gastric Emptying. III. Gastric Residence Time of a Nondisintegrating Geometric Shape in Human Volunteers | Joseph A. Fix, Robyn Cargill and Karen Engle |
| 1090-1092 | Transient Steady-State Analysis: Application in the Determination of the Relative Formation and Elimination Clearances of Two Major Carbamazepine Metabolites in Humans | Lillian E. Riad, Keith K. H. Chan and Ronald J. Sawchuk |
| 1093-1095 | Physiological Parameters in Laboratory Animals and Humans | Brian Davies and Tim Morris |
| 1096 | Editorial |
| 1097-1105 | Tertiary Amines Related to Brompheniramine: Preferred Conformations for N-Oxygenation by the Hog Liver Flavin-Containing Monooxygenase | John R. Cashman, Joy R. Celestial, Andrew Leach, Julie Newdoll and Sang Bum Park |
| 1106-1114 | Proteolysis of Human Growth Hormone by Rat Thyroid Gland in Vitro: Application of Electrospray Mass Spectrometry and N-Terminal Sequencing to Elucidate a Metabolic Pathway | Victor J. Wroblewski, Raymond E. Kaiser and Gerald W. Becker |
| 1115-1122 | Gelatin-Acacia Microcapsules for Trapping Micro Oil Droplets Containing Lipophilic Drugs and Ready Disintegration in the Gastrointestinal Tract | Hiroaki Jizomoto, Eri Kanaoka, Katsuji Sugita and Koichiro Hirano |
| 1123-1129 | Selective Paracellular Permeability in Two Models of Intestinal Absorption: Cultured Monolayers of Human Intestinal Epithelial Cells and Rat Intestinal Segments | Per Artursson, Anna-Lena Ungell and Jan-Erik Löfroth |
| 1130-1135 | Liposome-Mediated Delivery of Gallium to Macrophage-Like Cells in Vitro: Demonstration of a Transferrin-Independent Route for Intracellular Delivery of Metal Ions | Jukka Mönkkönen, Carolyn S. Brown, Tormaine T. Thompson and Timothy D. Heath |
| 1136-1143 | Solubilization of Thiazolobenzimidazole Using a Combination of pH Adjustment and Complexation with 2-Hydroxypropyl-β-Cyclodextrin | Abdi Y. Tinwalla, Barbara L. Hoesterey, Tian-xiang Xiang, Kap Lim and Bradley D. Anderson |
| 1144-1152 | Programmable Drug Delivery from an Erodible Association Polymer System | Xin Xu and Ping I. Lee |
| 1153-1156 | Characterization of Oil-in-Water Emulsions Prepared from Solid-State Emulsions: Effect of Matrix and Oil Phase | Merrick L. Shively |
| 1157-1164 | Biopharmaceutics of Didanosine in Humans and in a Model for Acid-Labile Drugs, the Pentagastrin-Pretreated Dog | Catherine A. Knupp, Wen Chyi Shyu, Elizabeth A. Morgenthien, James S. Lee and Rashmi H. Barbhaiya |
| 1165-1168 | Pharmacokinetics of Diltiazem and Its Metabolites in Dogs After Oral Administration of a Multiparticulate Sustained-Release Preparation | Kazuo Murata, Hiroshi Yamahara and Kazuo Noda |
| 1169-1173 | Stereoselective Interactions of Organic Cations with the Organic Cation Transporter in OK Cells | Ronda J. Ott and Kathleen M. Giacomini |
| 1174-1180 | Demethylation Kinetics of Aspartame and L-Phenylalanine Methyl Ester in Aqueous Solution | Raymond D. Skwierczynski and Kenneth A. Connors |
| 1181-1186 | Phenytoin–Lipid Conjugates: Chemical, Plasma Esterase-Mediated, and Pancreatic Lipase-Mediated Hydrolysis in Vitro | Gerhard K. E. Scriba |
| 1187-1190 | Substituted Xanthones as Selective and Reversible Monoamine Oxidase A (MAO-A) Inhibitors | Ulrike Thull, Silvia Kneubühler, Bernard Testa, M. Fernanda M. Borges and Madalena M. M. Pinto |
| 1191-1199 | Synthesis and Evaluation of Morpholinoalkyl Ester Prodrugs of Indomethacin and Naproxen | Vijay K. Tammara, Milind M. Narurkar, A. Michael Crider and Mansoor A. Khan |
| 1200-1205 | Conformational Analysis of the Opioid Phenylmorphan and Its 9α-Methyl Analogue in Solution Using High-Resolution Nuclear Magnetic Resonance Spectroscopy | Christine M. DiMeglio, Mark Froimowitz and Alexandros Makriyannis |
| 1206-1211 | The Hypolipidemic Effects of l-Acetyl-4-phenyl-l,2,4-triazolidine-3,5-dione in Rodents | Iris H. Hall, Rupenra Simlot, Patricia Day, O. T. Wong and Hamby ElSourady, et al. |
| 1212-1218 | Evaluation of Moisture Sorption by Tablet Cores Containing Superdisintegrants During the Aqueous Film Coating Process | Nazaneen Pourkavoos and Garnet E. Peck |
| 1219-1227 | Dissolution, Stability, and Morphological Properties of Conventional and Multiphase Poly(DL-Lactic-Co-Glycolic Acid) Microspheres Containing Water-Soluble Compounds | Motokazu Iwata and James W. McGinity |
| 1228-1231 | Stability of Liposomes in Vitro and Their Uptake by Rat Peyer's Patches Following Oral Administration | Yukihiko Aramaki, Hitoshi Tomizawa, Toshifumi Hara, Kiyoto Yachi and Hiroshi Kikuchi, et al. |
| 1232-1237 | Decreased Protein-Stabilizing Effects of Cryoprotectants Due to Crystallization | Ken-ichi Izutsu, Sumie Yoshioka and Tadao Terao |
| 1238-1242 | Transforming Growth Factor-α (TGF-α) in a Semisolid Dosage Form: Preservative and Vehicle Selection | Elizabeth L, Tan, Hemanshu S. Shah, Kirk J. Leister, Linda M. Kozick and Pamela Pasciak, et al. |
| 1243-1247 | Oral Immunization of Rats with Proteinoid Microspheres Encapsulating Influenza Virus Antigens | Noemi Santiago, Sam Milstein, Theresa Rivera, Elisa Garcia and Tabassum Zaidi, et al. |
| 1248-1251 | The Use of Statistical Indices to Gauge the Mixing Efficiency of a Conical Screening Mill | Richard P. Poska, Thomas R. Hill and Jan W. van Schaik |
| 1252 | Association News and Announcements |
| 1253-1261 | Synthesis and Pharmacokinetics of a New Liver-Specific Carrier, Glycosylated Carboxymethyl-Dextran, and Its Application to Drug Targeting | Makiya Nishikawa, Akiko Kamijo, Takuya Fujita, Yoshinobu Takakura and Hitoshi Sezaki, et al. |
| 1262-1267 | The Use of Solution Theories for Predicting Water Vapor Absorption by Amorphous Pharmaceutical Solids: A Test of the Flory–Huggins and Vrentas Models | Bruno C. Hancock and George Zografi |
| 1268-1273 | Peptide Stability in Drug Development. II. Effect of Single Amino Acid Substitution and Glycosylation on Peptide Reactivity in Human Serum | Michael F. Powell, Tracy Stewart, Laszlo Otvos, Laszlo Urge and Federico C. A. Gaeta, et al. |
| 1274-1279 | Preparation, Characterization, and Pharmaceutical Application of Linear Dextrins. I. Preparation and Characterization of Amylodextrin, Metastable Amylodextrins, and Metastable Amylose | Gerrit H. P. Te Wierik, Anko C. Eissens, Arie C. Besemer and Coenraad F. Lerk |
| 1280-1284 | Preparation, Characterization, and Pharmaceutical Application of Linear Dextrins. II. Complexation and Dispersion of Drugs with Amylodextrin by Freeze-Drying and Kneading | Gerrit H. P. Te Wierik, Anko C. Eissens, Arie C. Besemer and Coenraad F. Lerk |
| 1285-1290 | Evaluation of the Physicochemical Properties and Dissolution Characteristics of Mesalamine: Relevance to Controlled Intestinal Drug Delivery | Donna L. French and John W. Mauger |
| 1291-1294 | In Vivo Skin Penetration of Acitretin in Volunteers Using Three Sampling Techniques | Christian Surber, Klaus-P. Wilhelm, David Bermann and Howard I. Maibach |
| 1295-1300 | The Dissolution and Bioavailability of Etodolac from Capsules Exposed to Conditions of High Relative Humidity and Temperatures | Mike Dey, Robin Enever, Mike Kraml, David G. Prue and Doug Smith, et al. |
| 1301-1307 | Lack of Effect of Ammonium Glycyrrhizinate on the Morphology of Ovine Nasal Mucosa in Vitro | Patricia M. Reardon, Doris A. Wall, Timothy K. Hart, Philip L. Smith and Caroline H. Gochoco |
| 1308-1314 | Dissolution Modeling: Factors Affecting the Dissolution Rates of Polydisperse Powders | Allan T. K. Lu, Mary E. Frisella and Kevin C. Johnson |
| 1315-1320 | Convective Solvent Flow Across the Skin During Iontophoresis | Aeri Kim, Philip G. Green, Girish Rao and Richard H. Guy |
| 1321-1325 | A Floating Controlled-Release Drug Delivery System: In Vitro-in Vivo Evaluation | Subhash Desai and Sanford Bolton |
| 1326-1331 | Topical Penetration of Piroxicam Is Dependent on the Distribution of the Local Cutaneous Vasculature | Nancy A. Monteiro-Riviere, Alfred O. Inman, Jim E. Riviere, Stephen C. McNeill and Michael L. Francoeur |
| 1332-1337 | Rates of Systemic Degradation and Reticuloendothelial System (RES) Uptake of Thermosensitive Liposome Encapsulating Cisplatin in Rats | Katsumi Iga, Yasuaki Ogawa and Hajime Toguchi |
| 1338-1340 | Effect of Age on Distribution of Zidovudine (Azidothymidine) into the Cerebrospinal Fluid of Macaca nemestrina | Arturo Lopez-Anaya, Jashvant D. Unadkat, Dianne F. Calkins and Arnold L. Smith |
| 1341-1345 | Effect of Apparent Elimination Half-Life on Nitroglycerin-Induced Hemodynamic Rebound in Experimental Heart Failure | JohnAnthony Bauer and Ho-Leung Fung |
| 1346-1349 | Correlation Between the Plasma Concentration of Mepirodipine and Its Occupancy of Ca2+ Antagonist Receptors in Rats | Shizuo Yamada, Youmei Matsuoka and Ryohei Kimura |
| 1350-1355 | Phosphoryloxymethyl Carbamates and Carbonates—Novel Water-Soluble Prodrugs for Amines and Hindered Alcohols | Muhammad Safadi, Reza Oliyai and Valentino J. Stella |
| 1356-1362 | The Effect of Dihydronicotinate N-Substitution on the Brain-Targeting Efficacy of a Zidovudine Chemical Delivery System | Marcus E. Brewster, Emil Pop, Andrew J. Braunstein, Andreea C. Pop and Pascal Druzgala, et al. |
| 1363-1371 | The Effect of Swelling Characteristics of Superdisintegrants on the Aqueous Coating Solution Penetration into the Tablet Matrix During the Film Coating Process | Nazaneen Pourkavoos and Garnet E. Peck |
| 1372-1377 | Absorption of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) from Rat Nasal Mucosa | Minoru Machida, Keiko Sano, Masayuki Arakawa, Masahiro Hayashi and Shoji Awazu |
| 1378-1380 | The Influence of Blood Sampling Site in Nasal Drug Delivery Studies in Rats | Hing Char, Saran Kumar, Giuseppe Ciccone, David Piemontese and A.Waseem Malick, et al. |
| 1381-1384 | Single-Puff Particle-Size Analysis of Albuterol Metered-Dose Inhalers (MDIs) by High-Pressure Liquid Chromatography with Electrochemical Detection (HPLC-EC) | Moheb M. Nasr |
| 1385-1388 | Preparation of Small Gelatin and Albumin Microparticles by a Carbon Dioxide Atomization Process | Levent Öner and Michael J. Groves |
| 1389-1391 | Solid-State Emulsions: The Effects of Maltodextrin on Microcrystalline Aging | Scott L. Myers and Merrick L. Shively |
| 1392 | Association News and Announcements |
| 1393-1401 | Biotechnology and Bone Graft Substitutes | Richard A. Kenley, Kalvin Yim, Joan Abrams, Eyal Ron and Tom Turek, et al. |
| 1402-1410 | Enhancement of Tissue Delivery and Receptor Occupancy of Methylprednisolone in Rats by a Liposomal Formulation | Elena V. Mishina, Robert M. Straubinger, Nancy A. Pyszczynski and William J. Jusko |
| 1411-1419 | Microdialysis Calibration Using Retrodialysis and Zero-Net Flux: Application to a Study of the Distribution of Zidovudine to Rabbit Cerebrospinal Fluid and Thalamus | Yanfeng Wang, Shekman L. Wong and Ronald J. Sawchuk |
| 1420-1426 | Precision, Accuracy, and Data Acceptance Criteria in Biopharmaceutical Analysis | H. Thomas Karnes and Clark March |
| 1427-1433 | Inhibition of the Friend Retrovirus by Antisense Oligonucleotides Encapsulated in Liposomes: Mechanism of Action | C. Ropert, C. Malvy and P. Couvreur |
| 1434-1441 | Modulation of Human Ovarian Tumor Cell Sensitivity to N-(Phosphonacetyl)-L-Aspartate (PALA) by Liposome Drug Carriers | Amarnath Sharma, Ninfa L. Straubinger and Robert M. Straubinger |
| 1442-1445 | Pharmacokinetics, Mass Balance, and Induction Potential of a Novel GABA Uptake Inhibitor, CI-966 HC1, in Laboratory Animals | Louis L. Radulovic, Howard N. Bockbrader and Tsun Chang |
| 1446-1450 | Oral Absorption of FK506 in Rats | Akira Kagayama, Sachiyo Tanimoto, Jiro Fujisaki, Atunori Kaibara and Kaname Ohara, et al. |
| 1451-1457 | Plasma Pharmacokinetics of the Lactone and Carboxylate Forms of 20(S)-Camptothecin in Anesthetized Rats | Dennis O. Scott, Dilbir S. Bindra and Valentine J. Stella |
| 1458-1460 | The Effect of Aluminum Hydroxide Dissolution on the Bleeding of Aluminum Lake Dyes | Archana Desai, Garnet E. Peck, Janet E. Lovell, Joe L. White and Stanley L. Hem |
| 1461-1465 | The Interconversion Kinetics, Equilibrium, and Solubilities of the Lactone and Hydroxyacid Forms of the HMG-CoA Reductase Inhibitor, CI-981 | Albert S. Kearney, Lee F. Crawford, Surendra C. Mehta and Galen W. Radebaugh |
| 1466-1470 | Synthesis and Stability of Isotopically Labeled p-Chloro-m-Xylenol (PCMX) | John C. Reepmeyer, Walter L. Zielinski, Julian E. A. Leakey and Ying Si |
| 1471-1477 | Validation of a Peptide Map for Recombinant Porcine Growth Hormone and Application to Stability Assessment | Susan A. Charman, Louise E. McCrossin and William N. Charman |
| 1478-1483 | Stabilization of Lyophilized Porcine Pancreatic Elastase | Byeong S. Chang, Cynthia S. Randall and Yong S. Lee |
| 1484-1487 | The Effect of Salts on the Stability of β-Galactosidase in Aqueous Solution, as Related to the Water Mobility | Sumie Yoshioka, Yukio Aso, Ken-ichi Izutsu and Tadao Terao |
| 1488-1492 | Development of New Lipophilic Derivatives of Tetragastrin: Physicochemical Characteristics and Intestinal Absorption of Acyl-tetragastrin Derivatives in Rats | Takehiro Tenma, Etsuo Yodoya, Shigeru Tashima, Takuya Fujita and Masahiro Murakami, et al. |
| 1493-1499 | Histocultures of Patient Head and Neck Tumors for Pharmacodynamics Studies | Jessie L.-S. Ail, M. Guillaume Wientjes, Thomas J. Rosol, Antoinette Koolemans-Beynen and Eric A. Goebel, et al. |
| 1500-1506 | Validation of Reflectance Infrared Spectroscopy as a Quantitative Method to Measure Percutaneous Absorption In Vivo | Naruhito Higo, Aarti Naik, D. Bommi Bommannan, Russell O. Potts and Richard H. Guy |
| 1507-1515 | Physicochemical Characterization of High- and Low-Melting Phenylephrine Oxazolidines | Yihong Qiu, Ronald D. Schoenwald and J. Keith Guillory |
| 1516-1520 | Enhanced Bioavailability of Cefoxitin Using Palmitoylcarnitine. II. Use of Directly Compressed Tablet Formulations in the Rat and Dog | Steven C. Sutton, Edward L. LeCluyse, Karen Engle, James D. Pipkin and Joseph A. Fix |
| 1521-1526 | Flow-Through System Effects on in Vitro Analysis of Transdermal Systems | Joseph Sclafani, James Nightingale, Puchun Liu and Tamie Kurihara-Bergstrom |
| 1527-1532 | Sustained Local Anesthetic Release from Bioerodible Polymer Matrices: A Potential Method for Prolonged Regional Anesthesia | David B. Masters, Charles B. Berde, Sanjoy Dutta, Tom Turek and Robert Langer |
| 1533-1543 | Salt and Mesophase Formation in Aqueous Suspensions of Lauric Acid | Scott W. Smith and Bradley D. Anderson |
| 1544-1547 | Preparation and Characterization of Thermal- and pH-Sensitive Nanospheres | Xiao Yu Wu and Ping I. Lee |
| 1548-1551 | Intrapulmonary Delivery of Renin Inhibitory Peptides Results in Sustained Release Because of Saturable Transport | Ann M. Sheehy, Jennifer L. Hoover, Bob D. Rush, Karen F. Wilkinson and Thomas J. Vidmar, et al. |
| 1552 | Association News and Announcements |
| 1553-1562 | In Vitro Evaluation of Dexamethasone-β-D-Glucuronide for Colon-Specific Drug Delivery | Barbara Haeberlin, Werner Rubas, Harold W. Nolen III and David R. Friend |
| 1563-1571 | The Kinetics of Relaxin Oxidation by Hydrogen Peroxide | Tue H. Nguyen, John Burnier and Wei Meng |
| 1572-1579 | Chemical Pathways of Peptide Degradation. V. Ascorbic Acid Promotes Rather than Inhibits the Oxidation of Methionine to Methionine Sulfoxide in Small Model Peptides | Shihong Li, Christian Schöneich, George S. Wilson and Ronald T. Borchardt |
| 1580-1586 | Origin of the Isoelectric Heterogeneity of Monoclonal Immunoglobulin h1B4 | P. K. Tsai, Mark W. Bruner, Joseph I. Irwin, Charlotte C. Yu Ip and Cynthia N. Oliver, et al. |
| 1587-1590 | Determination of Acrolein in Urine by Liquid Chromatography and Fluorescence Detection of Its Quinoline Derivative | Sameer Al-Rawithi, Adnan El-Yazigi and Paul J. Nicholls |
| 1591-1596 | Sterilization of Liposomes by Heat Treatment | Nicolaas J. Zuidam, Stephen S. L. Lee and Daan J. A. Crommelin |
| 1597-1603 | Evaluation of Preflo® Modified Starches as New Direct Compression Excipients. I. Tabletting Characteristics | Pradeepkumar P. Sanghvi, Charles C. Collins and Atul J. Shukla |
| 1604-1610 | Pulmonary Absorption of Recombinant Methionyl Human Granulocyte Colony Stimulating Factor (r-huG-CSF) After Intratracheal Instillation to the Hamster | Ralph W. Niven, Fred D. Lott and Judith M. Cribbs |
| 1611-1614 | Pharmacokinetic Analysis and Cellular Distribution of the Anti-HIV Compound Succinylated Human Serum Albumin (Suc-HSA) in Vivo and in the Isolated Perfused Rat Liver | Robert W. Jansen, Peter Olinga, Geert Harms and Dirk K. F. Meijer |
| 1615-1619 | Recovery and Elimination of the Biotherapeutic Agent, Saccharomyces boulardii, in Healthy Human Volunteers | Susan M. Klein, Gary W. Elmer, Lynne V. McFarland, Christina M. Surawicz and René H. Levy |
| 1620-1626 | Utilization of a Human Intestinal Epithelial Cell Culture System (Caco-2) for Evaluating Cytoprotective Agents | Albert S. Tang, Prashant J. Chikhale, Praful K. Shah and Ronald T. Borchardt |
| 1627-1631 | Formulation, in Vitro Dissolution, and Ocular Bioavailability of High- and Low-Melting Phenylephrine Oxazolidines | Yihong Qiu, J. Keith Guillory and Ronald D. Schoenwald |
| 1632-1637 | Synthesis and Enhancing Effect of Dodecyl 2-(N,N-Dimethylamino)propionate on the Transepidermal Delivery of Indomethacin, Clonidine, and Hydrocortisone | Servet Büyüktimkin, Nadir Büyüktimkin and J. Howard Rytting |
| 1638-1641 | Chemical and α-Chymotrypsin-Mediated Proteolytic Degradation of Insulin in Bile Salt-Unsaturated Fatty Acid Mixed Micellar Systems | Yuping Li, Zezhi Shao and Ashim K. Mitra |
| 1642-1647 | A Critical Comparison of Some Raman Spectroscopic Techniques for Studies of Human Stratum Corneum | Adrian C. Williams, Brian W. Barry, Howell G. M. Edwards and Dennis W. Farwell |
| 1648-1653 | Stereoselective Dissolution of Propranolol Hydrochloride from Hydroxypropyl Methylcellulose Matrices | Sarma P. Duddu, Majid Vakilynejad, Fakhreddin Jamali and David J. W. Grant |
| 1654-1661 | Diffusion of lonizable Solutes Across Planar Lipid Bilayer Membranes: Boundary-Layer pH Gradients and the Effect of Buffers | Tian-xiang Xiang and Bradley D. Anderson |
| 1662-1667 | Transport and Hydrolysis of Enkephalins in Cultured Alveolar Epithelial Monolayers | LiYing Wang, David Toledo-Velasquez, Diane Schwegler-Berry, Joseph K. H. Ma and Yongyut Rojanasakul |
| 1668-1674 | Dipeptide Transport Across Rat Alveolar Epithelial Cell Monolayers | Kazuhiro Morimoto, Hiroshi Yamahara, Vincent H. L. Lee and Kwang-Jin Kim |
| 1675-1682 | Absorption and Disposition of a New Antiarrhythmic Agent Bidisomide in Man | Chyung S. Cook, Gregory B. Ames, Margaret E. Smith, Kenneth G. Kowalski and Aziz Karim |
| 1683-1687 | Evaluation of Sustained/Controlled-Release Dosage Forms of 3-Hydroxy-3-methylglutaryl–Coenzyme A (HMG-CoA) Reductase Inhibitors in Dogs and Humans | Haiyung Cheng, Steven C. Sutton, James D. Pipkin, Gaylen M. Zentner and J. Douglas Rogers, et al. |
| 1688-1692 | Application of Dual Radiotelemetric Technique in Studying Drug–Drug Interaction Between Diclofenac Sodium and Ranitidine HCl in Volunteers | Catherine Alioth, Robert A. Blum, David T. D'Andrea, Gregory M. Kochak and Lichen Teng, et al. |
| 1693-1695 | Prediction of Drug Release from Hydroxypropyl Methylcellulose (HPMC) Matrices: Effect of Polymer Concentration | Navnit Shah, Guohua Zhang, Vahe Apelian, Fuwen Zeng and Martin H. Infeld, et al. |
| 1696 | Oligonucleotides Get a Face-Lift | Sarah Noonberg |
| 1697 | BOOK REVIEWS |
| 1697-1698 | BOOK REVIEWS |
| 1699-1709 | Transport of Ionic Species in Skin: Contribution of Pores to the Overall Skin Conductance | Erik R. Scott, Ana I. Laplaza, Henry S. White and J. Bradley Phipps |
| 1710-1714 | A Correlation Between the Permeability Characteristics of a Series of Peptides Using an in Vitro Cell Culture Model (Caco-2) and Those Using an in Situ Perfused Rat Ileum Model of the Intestinal Mucosa | Dong-Chool Kirn, Philip S. Burton and Ronald T. Borchardt |
| 1715-1721 | Interleukin-2-Containing Liposomes: Interaction of Interleukin-2 with Liposomal Bilayers and Preliminary Studies on Application in Cancer Vaccines | Joep J. Bergers, Willem Den Otter, Hub F. J. Dullens, Catherina T. M. Kerkvliet and Daan J. A. Crommelin |
| 1722-1725 | Mechanism of Intestinal Absorption of Ranitidine and Ondansetron: Transport Across Caco-2 Cell Monolayers | Liang-Shang Gan, Poe-Hirr Hsyu, J. Frederick Pritchard and Dhiren Thakker |
| 1726-1731 | Phonophoresis of Methyl Nicotinate: A Preliminary Study to Elucidate the Mechanism of Action | James C. McElnay, Heather A. E. Benson, Robin Harland and Jonathan Hadgraft |
| 1732-1737 | In Vitro Extended-Release Properties of Drug-Loaded Poly(DL-Lactic Acid) Nanoparticles Produced by a Salting-Out Procedure | Eric Allémann, Jean-Christophe Leroux, Robert Gurny and Eric Doelker |
| 1738-1744 | Site-Specific Drug Delivery to Pilosebaceous Structures Using Polymeric Microspheres | Alain Rolland, Nathalie Wagner, Alain Chatelus, Braham Shroot and Hans Schaefer |
| 1745-1750 | Disparity of in Vitro and in Vivo Oleic Acid-Enhanced β-Estradiol Percutaneous Absorption Across Human Skin | Lynn K. Pershing, Greg E. Parry and Lyssa D. Lambert |
| 1751-1755 | Reverse Iontophoresis: Development of a Noninvasive Approach for Glucose Monitoring | Girish Rao, Peretz Glikfeld and Richard H. Guy |
| 1756-1759 | Influence of Skin Irritants on Percutaneous Absorption | Avinash Nangia, Etienne Camel, Bret Berner and Howard Maibach |
| 1760-1764 | Dose Proportionality and Population Characteristics of Oral Fadrozole Hydrochloride, an Aromatase Inhibitor, in Postmenopausal Women | Gregory M. Kochak, R. Leslie Choi and Elizabeth A. Entwistle |
| 1765-1771 | Assessment of Valproic Acid Serum–Cerebrospinal Fluid Transport by Microdialysis | Pamela L. Golden, Kenneth R. Brouwer and Gary M. Pollack |
| 1772-1776 | The Qualitative and Quantitative Analysis of Chlorpropamide Polymorphic Mixtures by Near-Infrared Fourier Transform Raman Spectroscopy | Andrew M. Tudor, Steven J. Church, Patrick J. Hendra, Martyn C. Davies and Colin D. Melia |
| 1777-1784 | Identification and Isolation of Chlorhexidine Digluconate Impurities | Larry K. Revelle, William H. Doub, Roger T. Wilson, Monica H. Harris and Aaron M. Rutter |
| 1785-1789 | Kinetic Analysis of Molecular Interconversion of Immunosuppressant FK506 by High-Performance Liquid Chromatography | Takashi Nishikawa, Hideyo Hasumi, Satomi Suzuki, Hiroaki Kubo and Hideki Ohtani |
| 1790-1792 | In Vitro/in Vivo Models for Peptide Oral Absorption: Comparison of Caco-2 Cell Permeability with Rat Intestinal Absorption of Renin Inhibitory Peptides | Robert A. Conradi, Karen F. Wilkinson, Bob D. Rush, Allen R. Hilgers and Mary J. Ruwart, et al. |
| 1793-1795 | Thermal Analysis and Solution Calorimetry Studies on Losartan Polymorphs | Lei-Shu Wu, Christine Gerard and Munir A. Hussain |
| 1796-1799 | Binding and Transport of Some Bioadhesive Plant Lectins Across Caco-2 Cell Monolayers | Claus-Michael Lehr and Vincent H. L. Lee |
| 1800-1805 | Scaleup of Oral Extended-Release Dosage Forms | J. P. Skelly, G. A. Van Buskirk, H. M. Arbit, G. L. Amidon and L. Augsburger, et al. |
| 1806-1811 | Bio-International '92, Conference on Bioavailability, Bioequivalence and Pharmacokinetic Studies | Henning H. Blume and Kamal K. Midha |
| 1812 | BOOK REVIEWS |
| 1812-1813 | BOOK REVIEWS |
| 1814 | Association News and Announcements |
| 1815-1818 | Author Index to Volume 10 (1993) |
| 1819-1822 | Subject Index to Volume 10 (1993) |
| 1 | Editorial |
| 2-11 | Immunopotentiation and Delivery Systems for Antigens for Single-Step Immunization: Recent Trends and Progress | M. Zahirul I. Khan, Joan P. Opdebeeck and Ian G. Tucker |
| 12-20 | Feasibility Study on Spray-Drying Protein Pharmaceuticals: Recombinant Human Growth Hormone and Tissue-Type Plasminogen Activator | Marco Mumenthaler, Chung C. Hsu and Rodney Pearlman |
| 21-29 | Moisture-Induced Aggregation of Lyophilized Insulin | Henry R. Costantino, Robert Langer and Alexander M. Klibanov |
| 30-37 | Transcellular Transport of Benzole Acid Across Caco-2 Cells by a pH-Dependent and Carrier-Mediated Transport Mechanism | Akira Tsuji, Hitomi Takanaga, Ikumi Tamai and Tetsuya Terasaki |
| 38-46 | Intracellular Visualization of Ampicillin-Loaded Nanoparticles in Peritoneal Macrophages Infected in Vitro with Salmonella typhimurium | Huguette Pinto-Alphandary, Olivier Balland, Michel Laurent, Antoine Andremont and Francis Puisieux, et al. |
| 47-53 | Conformational Analysis, Molecular Modeling, and Quantitative Structure–Activity Relationship Studies of Agents for the Inhibition of Astrocytic Chloride Transport | Chris L. Waller, Steven D. Wyrick, W. Evans Kemp, Hee Moon Park and Forrest T. Smith |
| 54-59 | Measurement of Glass Transition Temperatures of Freeze-Concentrated Solutes by Differential Scanning Calorimetry | Lih-Min Her and Steven L. Nail |
| 60-64 | Clearance Mechanisms of Atrial and Brain Natriuretic Peptides in Rats | Yukiya Hashimoto, Kazuwa Nakao, Norio Hama, Hiroo Imura and Sachiyo Mori, et al. |
| 65-71 | Acidic Fibroblast Growth Factor: Evaluation of Topical Formulations in a Diabetic Mouse Wound Healing Model | Bozena Matuszewska, Martina Keogan, Dennis M. Fisher, Keith A. Soper and Chao-Min Hoe, et al. |
| 72-76 | Acid-Catalyzed Peptide Bond Hydrolysis of Recombinant Human Interleukin 11 | Richard A. Kenley and Nicholas W. Warne |
| 77-82 | Primary Culture of Rat Gastric Epithelial Cells as an in Vitro Model to Evaluate Antiulcer Agents | Hongjian Zheng, Praful K. Shah and Kenneth L. Audus |
| 83-89 | Diffusion Rates and Transport Pathways of Fluorescein Isothiocyanate (FITC)-Labeled Model Compounds Through Buccal Epithelium | A. Janet Hoogstraate, Christopher Cullander, J. Fred Nagelkerke, Sevda Senel and J. Coos Verhoef, et al. |
| 90-95 | Effect of Cyclodextrins on Protein Binding of Drugs: The Diflunisal/Hydroxypropyl-β-Cyclodextrin Model Case | Evangelos E. Sideris, Michael A. Koupparis and Panayotis E. Macheras |
| 96-103 | Analysis of the Combined Effect of 1-Menthol and Ethanol as Skin Permeation Enhancers Based on a Two-Layer Skin Model | Daisuke Kobayashi, Takayasu Matsuzawa, Kenji Sugibayashi, Yasunori Morimoto and Masayuki Kimura |
| 104-107 | Interaction Between Drugs and Pressure-Sensitive Adhesives in Transdermal Therapeutic Systems | Takemasa Kokubo, Kenji Sugibayashi and Yasunori Morimoto |
| 108-110 | Preparation, Characterization, and Pharmaceutical Application of Linear Dextrins. III. Drug Release from Fatty Suppository Bases Containing Amylodextrin | Gerrit H. P. Te Wierik, Anko C. Eissens and Coenraad F. Lerk |
| 111-116 | An Organic Acid-Induced Sigmoidal Release System for Oral Controlled-Release Preparations | Shinji Narisawa, Minako Nagata, Chieko Danyoshi, Hiroyuki Yoshino and Kazuo Murata, et al. |
| 117-121 | Bioavailability of Flumequine After Semisimultaneous Administration to Veal Calves | Bert A. Meijer, Kristel G. F. Ceyssens, Wytze Th. de Jong and Ben I. J. A. C. de Grève |
| 122-127 | Biodistribution of Mixed Fluorocarbon–Hydrocarbon Dowel Molecules Used as Stabilizers of Fluorocarbon Emulsions: A Quantitative Study by Fluorine Nuclear Magnetic Resonance (NMR) | Leila Zarif, Michéle Postel, Bernard Septe, Leo Trevino and Jean G. Riess, et al. |
| 128-135 | Validation of a Variable Direction Hysteresis Minimization Pharmacodynamic Approach: Cardiovascular Effects of Alfentanil | Nishit B. Modi and Peter Veng-Pedersen |
| 136-143 | pH-Related Changes in the Absorption of Dipyridamole in the Elderly | Tanya L. Russell, Rosemary R. Berardi, Jeffrey L. Barnett, Tami L. O’Sullivan and John G. Wagner, et al. |
| 144-150 | Disposition of Glycosidase Inhibitors in the Isolated Perfused Rat Liver: Hepatobiliary and Subcellular Concentration Gradients of 1-Deoxymannojirimycin and N-Methyl-1-Deoxynojirimycin | Esther D. Faber, Johannes H. Proost, Roelof Oosting and Dirk K. F. Meijer |
| 151-155 | Influence of a Fat-Rich Meal on the Pharmacokinetics of a New Oral Formulation of Cyclosporine in a Crossover Comparison with the Market Formulation | Edgar A. Mueller, John M. Kovarik, Johannes B. van Bree, Joachim Grevel and Peter W. Lücker, et al. |
| 156-159 | Comparison of the Pharmacokinetics of an Ondansetron Solution (8 mg) When Administered Intravenously, Orally, to the Colon, and to the Rectum | Poe-Hirr Hsyu, J. Frederick Pritchard, Haig P. Bozigian, Thomas L. Lloyd and Rita H. Griffin, et al. |
| 160-164 | Pharmacokinetic Analysis of in Vivo Metabolism of Amino Acid or Dipeptide Conjugates of Salicylic Acid in Rabbit Intestinal Microorganisms | Koyo Nishida, Mitsuhiko Kido, Hitoshi Sasaki and Junzo Nakamura |
| 165-170 | Epimerization and Hydrolysis of Dalvastatin, a New Hydroxymethylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor | Chong Min Won |
| 171-180 | Psychometric Evaluation of Measures of Organizational Commitment and Intention to Quit Among Pharmaceutical Scientists | Sheldon Xiaodong Kong, Albert I. Wertheimer, Joaquima Serradell and William F. McGhan |
| 181-183 | Interaction of Zidovudine (Azidothymidine) with Isoprinosine and Probenecid in Macaca fascicularis | Sayed M. H. Al-Habet, Connie Nosbisch, Tracy Williamson, Che-Chung Tsai and Jashvant D. Unadkat |
| 184 | LEIDEN/AMSTERDAM CENTER FOR DRUG RESEARCH |
| 185-191 | In Vivo and in Vitro Analysis of Skin Penetration Enhancement Based on a Two-Layer Diffusion Model with Polar and Nonpolar Routes in the Stratum Corneum | Fumiyoshi Yamashita, Hiroto Bando, Yasuo Koyama, Shuji Kitagawa and Yoshinobu Takakura, et al. |
| 192-200 | Evaluation of Retinoids as Therapeutic Agents in Dermatology | Anita H. Lewin, Mary E. Bos, F. Christopher Zusi, Xina Nair and Gary Whiting, et al. |
| 201-205 | Solubility Predictions for Solid Nitriles and Tertiary Amides Based on the Mobile Order Theory | Paul Ruelle and Ulrich W. Kesselring |
| 206-212 | A Mixed Micellar Formulation Suitable for the Parenteral Administration of Taxol | Hayat Alkan-Onyuksel, Suganthi Ramakrishnan, Hee-Byung Chai and John M. Pezzuto |
| 213-220 | Pharmacokinetics and Tissue Distribution of Recombinant Human Transforming Growth Factor Beta1 After Topical and Intravenous Administration in Male Rats | Thomas F. Zioncheck, Sharon A. Chen, Louise Richardson, Marina Mora-Worms and Catherine Lucas, et al. |
| 221-225 | Solute Absorption from the Airways of the Isolated Rat Lung. IV. Mechanisms of Absorption of Fluorophore-Labeled Poly-α,β-[N(2-Hydroxyethyl)-DL-Aspartamide] | Peter R. Byron, Zhuang Sun, Hirokazu Katayama and Frantisek Rypacek |
| 226-230 | Colonic Absorption of Insulin-like Growth Factor I in Vitro | Elizabeth Quadros, Nancy M. Landzert, Sheryl LeRoy, Francis Gasparini and Gregory Worosila |
| 231-236 | Formulation and in Vitro–in Vivo Evaluation of Buccoadhesive Morphine Sulfate Tablets | Şule Anlar, Yilmaz Çapan, Olgun Güven, Ahmet Göğüş and Turgay Dalkara, et al. |
| 237-242 | The Physicochemical Properties, Plasma Enzymatic Hydrolysis, and Nasal Absorption of Acyclovir and Its 2′-Ester Prodrugs | Zezhi Shao, Gee-Bae Park, Ramesh Krishnamoorthy and Ashim K. Mitra |
| 243-250 | Bile Salt–Fatty Acid Mixed Micelles as Nasal Absorption Promoters. III. Effects on Nasal Transport and Enzymatic Degradation of Acyclovir Prodrugs | Zezhi Shao and Ashim K. Mitra |
| 251-256 | Identification of the Pathway of lontophoretic Drug Delivery: Light and Ultrastructural Studies Using Mercuric Chloride in Pigs | Nancy A. Monteiro-Riviere, Alfred O. Inman and Jim E. Riviere |
| 257-266 | Comparative Molecular Field Analysis Combined with Physicochemical Parameters for Prediction of Polydimethylsiloxane Membrane Flux in Isopropanol | Rong Liu and Lloyd E. Matheson |
| 267-271 | Intestinal Absorption of (–)-Carbovir in the Rat | Inmaculada Soria and Cheryl L. Zimmerman |
| 272-277 | The Controlled Release of Prednisolone Using Alginate Gel | Shinya Sugawara, Teruko Imai and Masaki Otagiri |
| 278-282 | Effect of Formulation Additives upon the Intranasal Bioavailability of a Peptide Drug: Tetracosactide (ACTH1−24) | Patrick Wüthrich, Myriam Martenet and Pierre Buri |
| 283-287 | Determination of Transport Rates for Arginine and Acetaminophen in Rabbit Intestinal Tissues in Vitro | Peter W. Swaan, Gary J. Marks, Frederick M. Ryan and Philip L. Smith |
| 288-294 | Effect of Some Penetration Enhancers on Epithelial Membrane Lipid Domains: Evidence from Fluorescence Spectroscopy Studies | T. Marjukka Turunen, Arto Urtti, Petteri Paronen, Kenneth L. Audus and J. Howard Rytting |
| 295-300 | Effect of the H2-Receptor Antagonist Cimetidine, on the Pharmacokinetics and Pharmacodynamics of the H1-Receptor Antagonists Hydroxyzine and Cetirizine in Rabbits | Xueyu Chen, F. Estelle R. Simons and Keith J. Simons |
| 301-304 | Improved Dose Linearity of Cyclosporine Pharmacokinetics from a Microemulsion Formulation | Edgar A. Mueller, John M. Kovarik, Johannes B. van Bree, Wolfgang Tetzloff and Joachim Grevel, et al. |
| 305-311 | In Vivo and in Vitro Blood–Brain Barrier Transport of 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors | Akira Saheki, Tetsuya Terasaki, Ikumi Tamai and Akira Tsuji |
| 312-317 | Efflux of Zidovudine and 2′,3′-Dideoxyinosine Out of the Cerebrospinal Fluid When Administered Alone and in Combination to Macaca nemestrina | Tove Tuntland, Rashid J. Ravasco, Sayed Al-Habet and Jashvant D. Unadkat |
| 318-323 | Phenobarbital Removal Characteristics of Three Brands of Activated Charcoals: A System Analysis Approach | Nishit B. Modi, Peter Veng-Pedersen, Dale Eric Wurster, Mary J. Berg and Dorothy D. Schottelius |
| 324-330 | In Vitro and in Vivo Transport of Zidovudine (AZT) Across the Blood–Brain Barrier and the Effect of Transport Inhibitors | Rosalinde Masereeuw, Ulrich Jaehde, Mariska W. E. Langemeijer, Albertus G. de Boer and Douwe D. Breimer |
| 331-336 | Fluorometric Study of the Molecular States of 2,5-Diphenyloxazole in Ground Mixtures with γ-Cyclodextrin | Keiji Yamamoto, Toshio Oguchi, Etsuo Yonemochi, Yoshisuke Matsumura and Yoshinobu Nakai |
| 337-340 | Entrapment of Proteins in Poly(L-Lactide) Microspheres Using Reversed Micelle Solvent Evaporation | Yoshiki Hayashi, Sumie Yoshioka, Yukio Aso, Alain Li Wan Po and Tadao Terao |
| 341-344 | Lack of Pharmacokinetic Interaction Between Cimetidine and Tirilazad Mesylate | Joseph C. Fleishaker, Laura K. Hulst and Gary R. Peters |
| 345-348 | Degradation of the Antiarthritic Prodrug, 3-Carboxy-5-methyl-N-[4-(trifluoromethoxy)phenyl]-4-isoxazolecarboxamide, in Aqueous Solution | Michael Brandl and James A. Kennedy |
| 349-350 | Further Commentary: Physiological Parameters in Laboratory Animals and Humans | Robert B. Sothern and Scott A. Gruber |
| 351-352 | Controlled Drug Release of Highly Water-Soluble Pentoxifylline from Time-Limit Disintegration-Type Wax Matrix Tablets | Makoto Otsuka and Yoshihisa Matsuda |
| 355-360 | Physicomechanical Characterization of the Extrusion-Spheronization Process. I. Instrumentation of the Extruder | Rajen D. Shah, Mohan Kabadi, David G. Pope and Larry L. Augsburger |
| 361-364 | Transport of Low and High Molecular Peptides Across Rabbit Peyer's Patches | Shingo Haseto, Hiroyuki Ouchi, Tomonori Isoda, Takashi Mizuma and Masahiro Hayashi, et al. |
| 365-371 | An Enzyme-Linked Immunosorbent Assay (ELISA) for Quantitation of Adducts of Granulocyte–Macrophage Colony Stimulating Factor (GM-CSF) and Human Serum Albumin (HSA) in Stressed Solution Mixtures | Ramasamy Kumarasamy, James Bausch, Diane Kopcha, Suman Patel and Eugene McGonigle |
| 372-376 | Plasma Factor Triggering Alternative Complement Pathway Activation by Liposomes | Kouichi Funato, Chikamasa Yamashita, Junko Kamada, Sachiko Tominaga and Hiroshi Kiwada |
| 377-383 | Comparative Analysis of Percutaneous Absorption Enhancement by d-Limonene and Oleic Acid Based on a Skin Diffusion Model | Yasuo Koyama, Hiroto Bando, Fumiyoshi Yamashita, Yoshinobu Takakura and Hitoshi Sezaki, et al. |
| 384-387 | Controlled Release of Paracetamol from Amylodextrin Tablets: In Vitro and in Vivo Results | Jacoba van der Veen, Anko C. Eissens and Coenraad F. Lerk |
| 388-392 | Pharmacokinetic Analysis of the Absorption Enhancing Action of Decanoic Acid and Its Derivatives in Rats | Koji Takahashi, Teruo Murakami, Atsuko Kamata, Ryoko Yumoto and Yutaka Higashi, et al. |
| 393-397 | Diffusion and Metabolism of Prednisolone Farnesylate in Viable Skin of the Hairless Mouse | Kakuji Tojo, Kayoko Yamada and Tomohiro Hikima |
| 398-401 | Solubility Enhancement of Nucleosides and Structurally Related Compounds by Complex Formation | Andrew X. Chen, S. William Zito and Robert A. Nash |
| 402-406 | Enhanced Hepatic Uptake of Liposomes Through Complement Activation Depending on the Size of Liposomes | Hideyoshi Harashima, Kazuya Sakata, Kouichi Funato and Hiroshi Kiwada |
| 407-411 | Stereospecific Distribution of Methylphenidate Enantiomers in Rat Brain: Specific Binding to Dopamine Reuptake Sites | Takao Aoyama, Hajime Kotaki, Yasufumi Sawada and Tatsuji Iga |
| 412-419 | Hydrogen Bonding Potential as a Determinant of the in Vitro and in Situ Blood–Brain Barrier Permeability of Peptides | Elsbeth G. Chikhale, Ka-Yun Ng, Philip S. Burton and Ronald T. Borchardt |
| 420-425 | Accumulation Kinetics of Propranolol in the Rat: Comparison of Michaelis– Menten-Mediated Clearance and Clearance Changes Consistent with the “Altered Enzyme Hypothesis” | Cornelia Weber, Klaus Stoeckel and David Lalka |
| 426-431 | Pharmacokinetics and Pharmacodynamics of L-703,014, a Potent Fibrinogen Receptor Antagonist, After Intravenous and Oral Administration in the Dog | Jeffrey S. Barrett, Robert J. Gould, Joan D. Ellis, Marie M. Holahan and Maria T. Stranieri, et al. |
| 432-437 | Site-Differential Gastrointestinal Absorption of Benazepril Hydrochloride in Healthy Volunteers | Keith K. H. Chan, Akshay Buch, Robert D. Glazer, Vivian A. John and William H. Barr |
| 438-441 | Dose-Dependent Pharmacokinetics of L-693,612, a Carbonic Anhydrase Inhibitor, Following Oral Administration in Rats | Bradley K. Wong, Patrick J. Bruhin and Jiunn H. Lin |
| 442-448 | Quantification and Visualization of the Transport of Octreotide, a Somatostatin Analogue, Across Monolayers of Cerebrovascular Endothelial Cells | Ulrich Jaehde, Rosalinde Masereeuw, Albertus G. De Boer, Gert Fricker and J. Fred Nagelkerke, et al. |
| 449-454 | Analytical Chiral Separation of the Stereoisomers of a Novel Carbonic Anhydrase Inhibitor and Its Deethylated Metabolite, and the Assignment of Absolute Configuration of the Human Metabolite and Chiral Degradation Products | Bogdan K. Matuszewski, Marvin L. Constanzer and Mary Kiganda |
| 455-457 | Novel Stabilizing Method for Antisense Oligodeoxynucleotides | Toshihiko Sueishi, Toshinobu Seki, Kazuhiko Juni, Tetsuya Hasegawa and Mineo Saneyoshi, et al. |
| 458-465 | 1H-NMR and 13C-NMR Spectral Assignments of Spiramycins I and III | Kumar Ramu, Sachin Shringarpure, Steven Cooperwood, John M. Beale and John S. Williamson |
| 466-469 | Rapid Synthesis of 3-[18F]Fluoro-l-(2′-Nitro-1′-Imidazolyl)-2-Propanol ([18F]Fluoromisonidazole) | Abdallah Cherif, David J. Yang, Wayne Tansey, E. Edmund Kim and Sidney Wallace |
| 470 | Pharmaceutical Research Reviewers for the Editorial Office, Japan (October 1992-September 1993) |
| 471-477 | The Relationship Between the Glass Transition Temperature and the Water Content of Amorphous Pharmaceutical Solids | Bruno C. Hancock and George Zografi |
| 478-484 | Preparation of Agglomerated Crystals for Direct Tabletting and Microencapsulation by the Spherical Crystallization Technique with a Continuous System | Toshiyuki Niwa, Hirofumi Takeuchi, Tomoaki Hino, Akira Itoh and Yoshiaki Kawashima, et al. |
| 485-490 | Chromatographic Methods for Quantitative Analysis of Native, Denatured, and Aggregated Basic Fibroblast Growth Factor in Solution Formulations | Victoria Sluzky, Zahra Shahrokh, Pamela Stratton, Gert Eberlein and Y. John Wang |
| 491-498 | Characterization of Aerosols of Human Recombinant Deoxyribonuclease I (rhDNase) Generated by Jet Nebulizers | David Cipolla, Igor Gonda and Steven J. Shire |
| 499-502 | Controlled Release of Theophylline Monohydrate from Amylodextrin Tablets: In Vitro Observations | Jacoba Van der Veen, Gerrit H. P. Te Wierik, Liesbeth Van der Wal, Anko C. Eissens and Coenraad F. Lerk |
| 503-507 | Entrapping Efficiency and Drug Release Profile of an Oil-in-Water (o/w) Emulsion Formulation Using a Polydimethylsiloxane-Coated Glass Bead Assay | Toshiya Minagawa, Yoshiro Kohno, Toshio Suwa and Akira Tsuji |
| 508-512 | A Quantitative Concept of the Mechanism of Intestinal Lymphatic Transfer of Lipophilic Molecules | Teruhisa Ichihashi, Toru Nagasaki, Yasushi Takagishi and Hideo Yamada |
| 513-517 | Alveolar Permeability Enhancement by Oleic Acid and Related Fatty Acids: Evidence for a Calcium-Dependent Mechanism | Li Ying Wang, Joseph K. H. Ma, Wei Fang Pan, David Toledo-Velasquez and Carl J. Malanga, et al. |
| 518-521 | Activation of Fc Receptor-Mediated Phagocytosis by Mouse Peritoneal Macrophages Following the Intraperitoneal Administration of Liposomes | Yukihiko Aramaki, Makoto Murai and Seishi Tsuchiya |
| 522-527 | The Effect of Temperature and pH on the Solubility of Quinolone Compounds: Estimation of Heat of Fusion | Xuanqiang Yu, Gail L. Zipp and G. W. Ray Davidson III |
| 528-535 | Oral Absorption of Peptides: The Effect of Absorption Site and Enzyme Inhibition on the Systemic Availability of Metkephamid | Peter Langguth, Hans P. Merkle and Gordon L. Amidon |
| 536-540 | Pharmacodynamics of Phenobarbital Anesthesia and Pentylenetetrazol-Induced Maximal Seizures in a Rat Model of Neoplastic Spinal Cord Compression | Amnon Hoffman, Jose Alfon, Tzony Siegal and Tali Siegal |
| 541-544 | Effects of Acute and Chronic Inflammation on the Pharmacokinetics of Prednisolone in Rats | Varun Garg, Yuen Yi Hon and William J. Jusko |
| 545-548 | Simulation for the Analysis of Distorted Pharmacodynamic Data | Yukiya Hashimoto, Junko Ozaki, Toshiko Koue, Atsuko Odani and Masato Yasuhara, et al. |
| 549-555 | Pharmacokinetics of Levodopa and Carbidopa in Rats Following Different Routes of Administration | Eva Bredberg, Hans Lennernäs and Lennart Paalzow |
| 556-560 | An Assessment of the 4-6-20 Rule for Acceptance of Analytical Runs in Bioavailability, Bioequivalence, and Pharmacokinetic Studies | Robert O. Kringle |
| 561-565 | The Use of Fourier Transform Infrared (FT-IR) Spectroscopy to Determine the Diffusion Coefficients of Alcohols in Polydimethylsiloxane | Varaporn Buraphacheep, Dale Eric Wurster and Dale E. Wurster |
| 566-570 | A Simple and Rapid Fluorometric Determination Method of α1-Acid Glycoprotein in Serum Using Quinaldine Red | Hitoshi Imamura, Toru Maruyama, Hiroaki Okabe, Hidekata Shimada and Masaki Otagiri |
| 571-574 | Synthesis and Evaluation of Amino Analogues of Valproic Acid | K. R. Scott, Sandra Adesioye, Patricia B. Ayuk, Ivan O. Edafiogho and Dolly John, et al. |
| 575-579 | Development and Evaluation of Sustained-Release Ibuprofen–Wax Microspheres. II. In Vitro Dissolution Studies | Christianah M. Adeyeye and James C. Price |
| 580-584 | Dosing Reproducibility from Experimental Albuterol Suspension Metered-Dose Inhalers | Peter R. Byron |
| 585-588 | Adsorption of Beta-Blockers onto Polyisobutylcyanoacrylate Nanoparticles Measured by Depletion and Dielectric Methods | Emmanuelle Benoit, Odile Prot, Philippe Maincent and Jacques Bessière |
| 589-591 | A Novel Assay to Determine the Hemolytic Activity of Drugs Incorporated in Colloidal Carrier Systems | Thomas K. Bock and Bernd W. Müller |
| 592-594 | Variability in Gastric pH and Delayed Gastric Emptying in Yucatan Miniature Pigs | Rebecca L. Oberle and Helena Das |
| 595-599 | Mathematical Analysis and Optimization of a Flow-Through Diffusion Cell System | Hoo-Kyun Choi and James T. Angello |
| 600-603 | Videomicroscopy Techniques for Agglomeration Studies | Lorraine E. Pena, Barbara L. Lee and James F. Stearns |
| 604-607 | Effects of Sampling Chamber Volume and Geometry on Aerodynamic Size Distributions of Metered-Dose Inhalation Aerosols Measured with the Andersen Cascade Impactor | Michiel Van Oort, Rebecca O. Gollmar and Robert J. Bohinski |
| 608 | ROCKEFELLER SCIENCE FOR DEVELOPMENT PRIZE CURRENT RESEARCH INTO THERAPIES FOR ALZHEIMER'S DISEASE LEIDEN/AMSTERDAM CENTER FOR DRUG RESEARCH FOURTH SYMPOSIUM OF THE PHARMACEUTICAL COMPACTION RESEARCH LABORATORY & INFORMATION CENTER |
| 609-615 | Cellular Toxicity of Aminoglycoside Antibiotics in G418-Sensitive and -Resistant LLC-PK1 Cells | Mikihisa Takano, Masahiro Okuda, Masato Yasuhara and Ryohei Hori |
| 616-623 | Hardness Anisotropy of Acetaminophen Crystals | Wendy C. Duncan-Hewitt, David L. Mount and Alfred Yu |
| 624-632 | The Stabilization of a Human IgM Monoclonal Antibody with Poly(vinylpyrrolidone) | Wayne R. Gombotz, Susan C. Pankey, Duke Phan, Randy Drager and Karen Donaldson, et al. |
| 633-641 | Differential Disposition of Soluble and Liposome-Formulated Human Recombinant Interleukin-7: Effects on Blood Lymphocyte Population in Guinea Pigs | Tot Bui, Connie Faltynek and Rodney J. Y. Ho |
| 642-647 | Improved Intestinal Absorption of an Enteric-Coated Sodium Ursodeoxycholate Formulation | Aldo Roda, Enrico Roda, Egidio March, Patrizia Simoni and Carolina Cerrè, et al. |
| 648-653 | The Contribution of Intestinal Secretion to the Dose-Dependent Absorption of Celiprolol | Shiu-Ming Kuo, Brian R. Whitby, Per Artursson and John A. Ziemniak |
| 654-658 | An Application of the Hydrodynamic Pore Theory to Percutaneous Absorption of Drugs | Tomomi Hatanaka, Eiichiro Manabe, Kenji Sugibayashi and Yasunori Morimoto |
| 659-664 | Estradiol Permeation from Nonionic Surfactant Vesicles Through Human Stratum Corneum in Vitro | Hans E. J. Hofland, Ronald van der Geest, Harry E. Bodde, Hans E. Junginger and Joke A. Bouwstra |
| 665-673 | Transcellular Permeability of Chlorpromazine Demonstrating the Roles of Protein Binding and Membrane Partitioning | Geri A. Sawada, Norman F. H. Ho, Larry R. Williams, Craig L. Barsuhn and Thomas J. Raub |
| 674-679 | Mucoadhesion of Latexes. I. Analytical Methods and Kinetic Studies | Carlo Durrer, Juan Manuel Irache, Francis Puisieux, Dominique Duchêne and Gilles Ponchel |
| 680-683 | Mucoadhesion of Latexes. II. Adsorption Isotherms and Desorption Studies | Carlo Durrer, Juan Manuel Irache, Francis Puisieux, Dominique Duchêne and Gilles Ponchel |
| 684-686 | Application of in Vivo Microdialysis to Transdermal Absorption of Methotrexate in Rats | Kenji Matsuyama, Mikiro Nakashima, Yukiko Nakaboh, Masataka Ichikawa and Tadanori Yano, et al. |
| 687-697 | Studies on the Effects of Applied Voltage and Duration on Human Epidermal Membrane Alteration/Recovery and the Resultant Effects upon Iontophoresis | Hirohiko Inada, Abdel-Halim Ghanem and William I. Higuchi |
| 698-703 | Pharmacokinetics and Metabolism of Diclofenac Sodium in Yucatan Miniature Pigs | Rebecca L. Oberle, Helena Das, Shekman L. Wong, Keith K. H. Chan and Ronald J. Sawchuk |
| 704-708 | The Effect of Immunosuppression by Total-Body Irradiation on the Pharmacodynamics of Centrally Active Drugs in Rats | Amnon Hoffman, Jose Alfon, Gustav Habib, Evelyne Pinto and Raphael Gorodetsky |
| 709-714 | NM-Win: A Personal Computer-Based Microsoft® Windows™ Front-End to NONMEM IV | Jonathan P. Vielhaber and Jeffrey S. Barrett |
| 715-722 | Bioequivalence: Performance of Several Measures of Extent of Absorption | Frédéric Y. Bois, Thomas N. Tozer, Walter W. Hauck, Mei-Ling Chen and Rabindra Patnaik, et al. |
| 723-727 | Fourier Transform Infrared (FTIR) Spectrometry for the Assay of Polyhedral Boron Compounds in Plasma and Pharmaceutical Formulations | Yohanes Setiawan, Tor Rise and Douglas E. Moore |
| 728-732 | On-Line Moisture Detection for a Microwave Vacuum Dryer | Jackie G. White |
| 733-737 | A Novel Nuclear Magnetic Resonance (NMR) Imaging Method for Measuring the Water Front Penetration Rate in Hydrophilic Polymer Matrix Capsule Plugs and Its Role in Drug Release | Muhammad Ashraf, Virginia L. luorno, David Coffin-Beach, C. Anderson Evans and Larry L. Augsburger |
| 738-746 | Transport of Human Recombinant Brain-Derived Neurotrophic Factor (BDNF) Through the Rat Blood−Brain Barrier in Vivo Using Vector-Mediated Peptide Drug Delivery | William M. Pardridge, Young-Sook Kang and Jody L. Buciak |
| 747-750 | The Bioavailability of Intranasal Salmon Calcitonin in Healthy Volunteers with and Without a Permeation Enhancer | William A. Lee, Richard D. Ennis, John P. Longenecker and Per Bengtsson |
| 751-758 | Chemical Pathways of Peptide Degradation. VI. Effect of the Primary Sequence on the Pathways of Degradation of Aspartyl Residues in Model Hexapeptides | Cecilia Oliyai and Ronald T. Borchardt |
| 759-763 | A Sensitive, High-Volume, Colorimetric Assay for Protein Phosphatases | Diana K. Fisher and Terry J. Higgins |
| 764-771 | Chemical and Physical Stability of Chimeric L6, a Mouse−Human Monoclonal Antibody | Mehdi Paborji, Nancy L. Pochopin, William P. Coppola and Joseph B. Bogardus |
| 772-773 | Effect of Hepatic Cirrhosis on the Pharmacodynamics and Pharmacokinetics of Mivacurium in Humans | Gerhard Levy |
| 774-775 | Determination of Solute–Polymer Interaction Properties via Two-Stage Extraction | Dennis R. Jenke |
| 776 | ROCKEFELLER SCIENCE FOR DEVELOPMENT PRIZECURRENT RESEARCH INTO THERAPIES FOR ALZHEIMER'S DISEASEINDUSTRIAL RHEOLOGY: PRINCIPLES AND PRACTICE |
| 777-783 | Pharmaceutical Applications of Microcalorimetry | Michael J. Koenigbauer |
| 784-793 | The Role of Intramolecular Nucleophilic Catalysis and the Effects of Self-Association on the Deamidation of Human Insulin at Low pH | Richard T. Darrington and Bradley D. Anderson |
| 794-799 | Mucus Gel Thickness and Turnover in the Gastrointestinal Tract of the Rat: Response to Cholinergic Stimulus and Implication for Mucoadhesion | Abraham Rubinstein and Boaz Tirosh |
| 800-808 | Predictions of in Vivo Plasma Concentrations from in Vitro Release Kinetics: Application to Doxepin Parenteral (I.M.) Suspensions in Lipophilic Vehicles in Dogs | Christina Gido, Peter Langguth and Ernst Mutschler |
| 809-815 | Percutaneous Absorption of 2′,3′-Dideoxyinosine in Rats | Elora Mukherji, Nancy J. Millenbaugh and Jessie L.-S. Au |
| 816-823 | Pharmacodynamic Models of Nitroglycerin-Induced Hemodynamic Tolerance in Experimental Heart Failure | John Anthony Bauer and Ho-Leung Fung |
| 824-830 | Pharmacokinetics and Bioinversion of Ibuprofen Enantiomers in Humans | Haiyung Cheng, J. Douglas Rogers, Joan L. Demetriades, Sherry D. Holland and James R. Seibold, et al. |
| 831-834 | The Cutoff Time Point of the Partial Area Method for Assessment of Rate of Absorption in Bioequivalence Studies | Panos Macheras, Mira Symillides and Christos Reppas |
| 835-838 | Microdialysis: An Alternative for in Vitro and in Vivo Protein Binding Studies | Anne Le Quellec, Sylvie Dupin, Ala Eldin Tufenkji, Patrick Genissel and Georges Houin |
| 839-843 | Oral Bioavailability of the Antiretroviral Agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from Three Formulations of the Prodrug Bis(pivaloyloxymethyl)-PMEA in Fasted Male Cynomolgus Monkeys | Kenneth C. Cundy, James A. Fishback, Jeng-Pyng Shaw, Min L. Lee and Kenneth F. Soike, et al. |
| 844-847 | HPLC Assay for FK 506 and Two Metabolites in Isolated Rat Hepatocytes and Rat Liver Microsomes | Beatrice Y. T. Perotti, Thomayant Prueksaritanont and Leslie Z. Benet |
| 848-854 | Inhibition of Rat Splenocyte Proliferation with Methylprednisolone: In Vivo Effect of Liposomal Formulation | Elena V. Mishina and William J. Jusko |
| 855-859 | Comparison of Two Otitis Media Models for the Study of Middle Ear Antimicrobial Pharmacokinetics | Daniel M. Canafax, Henry Russlie, Michael J. Lovdahl, Gary R. Erdmann and Chap T. Le, et al. |
| 860-864 | Effect of Streptococcus pneumoniae and Influenza A Virus on Middle Ear Antimicrobial Pharmacokinetics in Experimental Otitis Media | Gregg H. Jossart, Daniel M. Canafax, Gary R. Erdmann, Michael J. Lovdahl and Henry Q. Russlie, et al. |
| 865-868 | Chemical Interactions Between Drugs Containing Reactive Amines with Hydrolyzable Insoluble Biopolymers in Aqueous Solutions | Abraham J. Domb, Ludmila Turovsky and Raphael Nudelman |
| 869-874 | Poly(Alkylcyanoacrylate) Nanocapsules: Physicochemical Characterization and Mechanism of Formation | François Chouinard, Stéphane Buczkowski and Vincent Lenaerts |
| 875-881 | Structural Rheology of a Model Ointment | Lorraine E. Pena, Barbara L. Lee and James F. Stearns |
| 882-888 | Mechanical Properties of Dry and Wet Cellulosic and Acrylic Films Prepared from Aqueous Colloidal Polymer Dispersions Used in the Coating of Solid Dosage Forms | Roland Bodmeier and Ornlaksana Paeratakul |
| 889-896 | Novel Taxol Formulations: Preparation and Characterization of Taxol-Containing Liposomes | Amarnath Sharma and Robert M. Straubinger |
| 897-900 | Distribution of Brush-Border Membrane Peptidases Along the Rat Intestine | Jane P. F. Bai |
| 901-908 | Chemical Pathways of Peptide Degradation. VII. Solid State Chemical Instability of an Aspartyl Residue in a Model Hexapeptide | Cecilia Oliyai, Jitendra P. Patel, Linda Carr and Ronald T. Borchardt |
| 909-913 | Improvement of the Pulmonary Absorption of (Asu1,7)-Eel Calcitonin by Various Protease Inhibitors in Rats | Takahiro Morita, Akira Yamamoto, Yoshinobu Takakura, Mitsuru Hashida and Hitoshi Sezaki |
| 914-916 | Geometric Approach for Zero-Order Release of Drugs Dispersed in an Inert Matrix | Mohsen A. Bayomi |
| 917-920 | Interaction Between Ciprofloxacin and Metal Cations: Its Influence on Physicochemical Characteristics and Antibacterial Activity | Ronald C. Li, David E. Nix and Jerome J. Schentag |
| 921-924 | Inhibition of Human CYP3A Catalyzed 1′-Hydroxy Midazolam Formation by Ketoconazole, Nifedipine, Erythromycin, Cimetidine, and Nizatidine | Steven A. Wrighton and Barbara J. Ring |
| 925-928 | A Regulatory and Industrial Perspective of the Use of Carbon-14 and Tritium Isotopes in Human ADME Studies | Jeremy G. Dain, Jerry M. Collins and William T. Robinson |
| 929-935 | Characterization of Convective Solvent Flow During Iontophoresis | M. Begoña Delgado-Charro and Richard H. Guy |
| 936-944 | Major Degradation Products of Basic Fibroblast Growth Factor: Detection of Succinimide and Iso-aspartate in Place of Aspartate15 | Zahra Shahrokh, Gert Eberlein, Doug Buckley, Mallik V. Paranandi and Dana W. Aswad, et al. |
| 945-950 | Interspecies Scaling of Cimetidine–Theophylline Pharmacokinetic Interaction: Interspecies Scaling in Pharmacokinetic Interactions | Alicia R. Gascón, Begoña Calvo, Rosa María Hernández, Alfonso Domínguez-Gil and José-Luis Pedraz |
| 951-960 | Disposition of Azole Antifungal Agents. II. Hepatic Binding and Clearance of Dichlorophenyl-Bis-triazolylpropanol (DTP) in the Rat | Helen L. Bomont, Michael H. Tarbit, Michael J. Humphrey and J. Brian Houston |
| 961-965 | Disposition of Azole Antifimgal Agents. III. Binding of Fluconazole and Other Azoles in Rat Liver | Christopher M. Ervine and J. Brian Houston |
| 966-974 | Bioequivalence: Performance of Several Measures of Rate of Absorption | Frédéric Y. Bois, Thomas N. Tozer, Walter W. Hauck, Mei-Ling Chen and Rabindra Patnaik, et al. |
| 975-978 | Carrier-Mediated Transport of H1-Antagonist at the Blood–Brain Barrier: Mepyramine Uptake into Bovine Brain Capillary Endothelial Cells in Primary Monolayer Cultures | Masahiro Yamazaki, Tetsuya Terasaki, Kuniaki Yoshioka, Osamu Nagata and Hideo Kato, et al. |
| 979-983 | A Drug Dissolution Monitor Employing Multiple Fiber Optic Probes and a UV/Visible Diode Array Spectrophotometer | Chi-Shi Chen and Chris W. Brown |
| 984-989 | Drug Binding by Reservoirs in Elastomeric Infusion Devices | Dennis R. Jenke |
| 990-994 | Microbial and Mammalian Metabolism Studies of the Semisynthetic Antimalarial, Anhydrodihydroartemisinin | Sherief I. Khalifa, John K. Baker, Robin D. Rogers, Farouk S. El-Feraly and Charles D. Hufford |
| 995-999 | Physical Stability and Protein Stability of Freeze-Dried Cakes During Storage at Elevated Temperatures | Ken-ichi Izutsu, Sumie Yoshioka and Shigeo Kojima |
| 1000-1003 | Transdermal lontophoretic Delivery of Luteinizing Hormone Releasing Hormone (LHRH): Effect of Repeated Administration | Mark C. Heit, Nancy A. Monteiro-Riviere, Friederike L. Jayes and Jim E. Riviere |
| 1004-1008 | Thermal Stability of Low Molecular Weight Urokinase During Heat Treatment. II. Effect of Polymeric Additives | Michael Vrkljan, Thomas M. Foster, Michael E. Powers, Jack Henkin and William R. Porter, et al. |
| 1009-1015 | Dose and Load Studies for Subcutaneous and Oral Delivery of Poly(lactide-co-glycolide) Microspheres Containing Ovalbumin | Takahiro Uchida, Stephen Martin, Todd P. Foster, Richard C. Wardley and Susan Grimm |
| 1016-1022 | Polystyrene-Poly (Ethylene Glycol) (PS-PEG2000) Particles as Model Systems for Site Specific Drug Delivery. 2. The Effect of PEG Surface Density on the in Vitro Cell Interaction and in VivoBiodistribution | Susan E. Dunn, Anne Brindley, Stanley S. Davis, Martyn C. Davies and Lisbeth Illum |
| 1023-1029 | Measurement of Glass Transition Temperatures in Freeze Concentrated Solutions of Non-Electrolytes by Electrical Thermal Analysis | Lih-Min Her, Raymond P. Jefferis, Larry A. Gatlin, Bryan Braxton and Steven L. Nail |
| 1030-1034 | Accelerated Degradation of Poly(ε-caprolactone) by Organic Amines | Wen-Jen Lin, Douglas R. Flanagan and Robert J. Linhardt |
| 1035-1041 | Estimation of Skin Target Site Acyclovir Concentrations Following Controlled (Trans)dermal Drug Delivery in Topical and Systemic Treatment of Cutaneous HSV-1 Infections in Hairless Mice | George Imanidis, Wei-qi Song, Paul H. Lee, Muh-Hwan Su and Earl R. Kern, et al. |
| 1042-1047 | Effects of Surfactants on Amiodarone Intestinal Absorption. I. Sodium Laurylsulfate | Rafael V. Martín-Algarra, Rosa M. Pascual-Costa, Matilde Merino and Vicente G. Casabó |
| 1048-1055 | Pulmonary Delivery of Detirelix by Intratracheal Instillation and Aerosol Inhalation in the Briefly Anesthetized Dog | David B. Bennett, Elizabeth Tyson, Clinton A. Nerenberg, Sylvia Mah and Jennifer S. de Groot, et al. |
| 1056-1059 | Pharmacokinetics of Detirelix Following Intratracheal Instillation and Aerosol Inhalation in the Unanesthetized Awake Sheep | Hans Schreier, Kenneth J. McNicol, David B. Bennett, Zvi Teitelbaum and Hartmut Derendorf |
| 1060-1064 | Degradation of O6-Benzylguanine in Aqueous Polyethylene Glycol 400 (PEG 400) Solutions: Concerns with Formaldehyde in PEG 400 | Dilbir S. Bindra, Todd D. Williams and Valentino J. Stella |
| 1065-1067 | The Requirement for a Retinoic Acid Lactone of 11-cis, 13-cis-Stereochemistry for Topical Dermatologic Activity | Anita H. Lewin, R. Richard Goehring, F. Christopher Zusi, Gerald J. Gendimenico and Xina Nair, et al. |
| 1068 | BOOK REVIEWS |
| 1068 | INDUSTRIAL RHEOLOGY: PRINCIPLES AND PRACTICE |
| 1069-1076 | Use of Stable Isotopes for Evaluation of Drug Delivery Systems: Comparison of Ibuprofen Release in Vivo and in Vitro from Two Biphasic Release Formulations Utilizing Different Rate-Controlling Polymers | Don L. Theis, Leo J. Lucisano and Gordon W. Halstead |
| 1077-1081 | Chemical Stability of Ethyl Icosapentate Against Autoxidation. II. Effect of Photoirradiation on Oxidation Kinetics | Reiko Teraoka, Makoto Otsuka and Yoshihisa Matsuda |
| 1082-1087 | Synthesis and in Vitro Study of a Diglyceride Prodrug of a Peptide | Florence Delie, Patrick Couvreur, Dino Nisato, Jean-Baptiste Michel and Francis Puisieux, et al. |
| 1088-1092 | Conformation of Amiodarone · HC1: A Solution and Solid State 13C-NMR Study | Renée C. Rao, Frédéric Lefebvre, Gérard Commenges, Catherine Castet and Lygie Miguel, et al. |
| 1093-1097 | Evaluation of Solubilizers in the Drug Release Testing of Hydrophilic Matrix Extended-Release Tablets of Felodipine | Bertil Abrahamsson, Dick Johansson, Arne Torstensson and Karin Wingstrand |
| 1098-1100 | An Improved Microscope Stage for Direct Observation of Freezing and Freeze Drying | Steven L. Nail, Lih-Min Her, Christopher P. B. Proffitt and Lisa L. Nail |
| 1101-1109 | Pulmonary Delivery of Powders and Solutions Containing Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) to the Rabbit | Ralph W. Niven, Fred D. Lott, Anna Y. Ip and Judith M. Cribbs |
| 1110-1114 | Novel Delivery of Antioxidant Enzyme Catalase to Alveolar Macrophages by Fc Receptor-Mediated Endocytosis | Jeannine Harrison, Xianglin Shi, LiYing Wang, Joseph K. H. Ma and Yongyut Rojanasakul |
| 1115-1120 | Stability of Acyl Derivatives of Insulin in the Small Intestine: Relative Importance of Insulin Association Characteristics in Aqueous Solution | Hiroyuki Asada, Takayuki Douen, Yoshiko Mizokoshi, Takuya Fujita and Masahiro Murakami, et al. |
| 1121-1126 | Receptor-Mediated Peptide Delivery in Pulmonary Epithelial Monolayers | Deepa Deshpande, David Toledo-Velasquez, Li Ying Wang, Carl J. Malanga and Joseph K. H. Ma, et al. |
| 1127-1131 | Comparison of Cell Proliferation and Toxicity Assays Using Two Cationic Liposomes | Katriina Lappalainen, Ilpo Jääskeläinen, Kari Syrjänen, Arto Urtti and Stina Syrjänen |
| 1132-1142 | Intestinal Permeability Enhancement: Efficacy, Acute Local Toxicity, and Reversibility | E. Scott Swenson, William B. Milisen and William Curatolo |
| 1143-1147 | Preparation of Three-Month Depot Injectable Microspheres of Leuprorelin Acetate Using Biodegradable Polymers | Hiroaki Okada, Yayoi Doken, Yasuaki Ogawa and Hajime Toguchi |
| 1148-1154 | Effect of Medium-Chain Glycerides on Physiological Properties of Rabbit Intestinal Epithelium in Vitro | Ping-Yang Yeh, Philip L. Smith and Harma Ellens |
| 1155-1159 | Characterization of Esterase and Alcohol Dehydrogenase Activity in Skin. Metabolism of Retinyl Palmitate to Retinol (Vitamin A) During Percutaneous Absorption | James Boehnlein, Adel Sakr, J. Leon Lichtin and Robert L. Bronaugh |
| 1160-1165 | Uptake of Nanoparticles by Rat Glomerular Mesangial Cells in Vivo and in Vitro | Luc Manil, Jean-Claude Davin, Charles Duchenne, Christine Kubiak and Jacqueline Foidart, et al. |
| 1166-1173 | Non-Isothermal and Isothermal Crystallization of Sucrose from the Amorphous State | Azita Saleki-Gerhardt and George Zografi |
| 1174-1179 | Cyclodextrins as Mucosal Absorption Promoters of Insulin. II. Effects of β-Cyclodextrin Derivatives on α-Chymotryptic Degradation and Enteral Absorption of Insulin in Rats | Zezhi Shao, Yuping Li, Todd Chermak and Ashim K. Mitra |
| 1180-1185 | Enhanced Delivery and Antitumor Activity of Doxorubicin Using Long-Circulating Thermosensitive Liposomes Containing Amphipathic Polyethylene Glycol in Combination with Local Hyperthermia | Sakae Unezaki, Kazuo Maruyama, Noriyuki Takahashi, Masataka Koyama and Tsutomu Yuda, et al. |
| 1186-1189 | Chitosan as a Novel Nasal Delivery System for Peptide Drugs | Lisbeth Illum, Nidal F. Farraj and Stanley S. Davis |
| 1190-1198 | A Modified Product Inhibition Model Describes the Nonlinear Pharmacokinetics of Nicorandil in Rats | Elizabeth L. Bachert, Zhuang-wu Li, Lin Zhao, Suk Jae Chung and Ho-Leung Fung |
| 1199-1203 | Sustained Suppression of the Pituitary-Gonadal Axis by Leuprorelin Three-Month Depot Microspheres in Rats and Dogs | Hiroaki Okada, Yayoi Doken, Yasuaki Ogawa and Hajime Toguchi |
| 1204-1206 | Phenobarbital Disposition in Adult and Neonatal Rabbits | Sun Dong Yoo, David E. Burgio and Patrick J. McNamara |
| 1207-1210 | Study of the Interaction Between β-Cyclodextrin and Chlorhexidine | Hong Qi, Toshiaki Nishihata and J. Howard Rytting |
| 1211-1215 | Synthesis of Novel Aminopropylguanidine Derivatives with Potential Antihypertensive Activity | Unsal Calis, John R. Finch, Edward E. Soltis and George A. Digenis |
| 1216-1220 | Workshop III Report: Scaleup of Liquid and Semisolid Disperse Systems | G. A. Van Buskirk, V. P. Shah, D. Adair, H. M. Arbit and S. V. Dighe, et al. |
| 1221 | Normal Volunteers Should Not Be Used for Bioavailability or Bioequivalence Studies of Clozapine | Rolf Pokorny, Marion J. Finkel and William T. Robinson |
| 1222 | 2ND EUROPEAN CONGRESS OF PHARMACEUTICAL SCIENCES EIGHTH ANNUAL PHARMACOKINETICS COURSE FOR PHARMACEUTICAL SCIENTISTS ONE-WEEK WORKSHOP ON ADVANCED METHODS IN PHARMACOKINETICS |
| 1222 | ERRATUM |
| 1223-1232 | Investigation of the Distribution of EAB 515 to Cortical ECF and CSF in Freely Moving Rats Utilizing Microdialysis | Bimal K. Malhotra, Michel Lemaire and Ronald J. Sawchuk |
| 1233-1238 | Effect of Moisture Sorption on Tabletting Characteristics of Spray Dried (15% Amorphous) Lactose | Tesfai Sebhatu, Ainin A. Elamin and Claes Ahlneck |
| 1239-1243 | Study on Pulmonary Delivery of Salmon Calcitonin in Rats: Effects of Protease Inhibitors and Absorption Enhancers | Shinzo Kobayashi, Shuji Kondo and Kazuhiko Juni |
| 1244-1249 | Effect of Epidermal Growth Factor on Cu, Zn-Superoxide Dismutase Expression in Cultured Fibroblasts from Rat Skin | Kohshi Nishiguchi, Yoshifumi Kiyohara, Fusao Komada, Seigo Iwakawa and Katsuhiko Okumura |
| 1250-1256 | Transepithelial Transport of Tyramine Across Filter-Grown MDCK Cells via a Poly(D-lysine) Carrier | Mitchell E. Taub, Jiansheng Wan and Wei-Chiang Shen |
| 1257-1264 | Brain Delivery of Biotin Bound to a Conjugate of Neutral Avidin and Cationized Human Albumin | Young-Sook Kang and William M. Pardridge |
| 1265-1269 | Effect of Ultrafilterable Platinum Concentration on Cisplatin and Carboplatin Cytotoxicity in Human Tumor and Bone Marrow Cells in Vitro | Henk-Jan Guchelaar, Elisabeth G. E. de Vries, Coby Meijer, Mariet T. Esselink and Edo Vellenga, et al. |
| 1270-1277 | Preparation and Characterization of Novel Poly(methylidene Malonate 2.1.2.)-Made Nanoparticles | François Lescure, Christine Seguin, Pascal Breton, Philippe Bourrinet and Didier Roy, et al. |
| 1278-1282 | Controlled Ocular Timolol Delivery: Systemic Absorption and Intraocular Pressure Effects in Humans | Arto Urtti, Harr Rouhiainen, Timo Kaila and Veyo Saano |
| 1283-1287 | Effects of Cholesterol and Cholesteryl Oleate on Lipolysis and Liver Uptake of Triglyceride/Phosphatidylcholine Emulsions in Rats | Tetsurou Handa, Yuko Eguchi and Koichiro Miyajima |
| 1288-1295 | A Convective-Diffusion Model for Dissolution of Two Non-interacting Drug Mixtures from Co-compressed Slabs Under Laminar Hydrodynamic Conditions | Seshadri Neervannan, Lloyd S. Dias, Marylee Z. Southard and Valentine J. Stella |
| 1296-1300 | Iontophoresis of a Model Peptide Across Human Skin in Vitro: Effects of Iontophoresis Protocol, pH, and Ionic Strength on Peptide Flux and Skin Impedance | W. H. M. Craane-van Hinsberg, L. Bax, N. H. M. Flinterman, J. Verhoef and H. E. Junginger, et al. |
| 1301-1305 | Solid-State Emulsions: Evaluation by 1H and 13C Solid-State Nuclear Magnetic Resonance | Merrick L. Shively and Steven F. Dec |
| 1306-1314 | Hindered Diffusion of Polar Molecules Through and Effective Pore Radii Estimates of Intact and Ethanol Treated Human Epidermal Membrane | Kendall D. Peck, Abdel-Halim Ghanem and William I. Higuchi |
| 1315-1319 | Liquid Scintillation Spectrometry of 5-Fluorouracil in Cervical Tissue Following in Vitro Surface Application of a Bioadhesive Cervical Patch | A. David Woolfson, Dermot F. McCafferty, Paul A. McCarron and John H. Price |
| 1320-1324 | Pulmonary Deposition and Clinical Response of99mTc-Labelled Salbutamol Delivered from a Novel Multiple Dose Powder Inhaler | Mika Vidgren, Jukka Arppe, Petra Vidgren, Liisa Hyvärinen and Pauli Vainio, et al. |
| 1325-1329 | The Determination of Interfacial Transfer Constants Using Side-by-Side Diffusion Cells | Gerold L. Mosher |
| 1330-1336 | Comparison of Single and Multiple Dose Pharmacokinetics Using Clinical Bioequivalence Data and Monte Carlo Simulations | Ahmed A. El-Tahtawy, André J. Jackson and Thomas M. Ludden |
| 1337-1345 | Distribution Kinetics of Salicylic Acid in the Isolated Perfused Rat Liver Assessed Using Moment Analysis and the Two-Compartment Axial Dispersion Model | Ziad Hussein, Andrew J. McLachlan and Malcolm Rowland |
| 1346-1351 | Modeling of the Saturable Time-Constrained Amoxicillin Absorption in Humans | Vladimir K. Piotrovskij, Gilles Paintaud, Gunnar Alván and Tomáš Trnovec |
| 1352-1354 | Peptide Liquid Crystals: Inverse Correlation of Kinetic Formation and Thermodynamic Stability in Aqueous Solution | Michael F. Powell, Jeffrey Fleitman, Lynda M. Sanders and Victoria C. Si |
| 1355-1357 | Impedance Spectroscopy in Human Skin. A Refined Model | Kyösti Kontturi and Lasse Murtomäki |
| 1358-1361 | Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2) | Per Artursson, Tuulikki Lindmark, Stanley S. Davis and Lisbeth Illum |
| 1362-1365 | Characterization of the Crystallinity of Drugs: B02669, a Case Study | Karen C. Thompson, Jerome P. Draper, Michael J. Kaufman and Gerald S. Brenner |
| 1366-1369 | Leucine Enkephalin Effects on Brain Microvessel Endothelial Cell Monolayer Permeability | Suzanne E. Thompson and Kenneth L. Audus |
| 1370-1378 | Adsorption of Oligonucleotides onto Polyisohexylcyanoacrylate Nanoparticles Protects Them Against Nucleases and Increases Their Cellular Uptake | Christine Chavany, Tula Saison-Behmoaras, Trung Le Doan, Francis Puisieux and Patrick Couvreur, et al. |
| 1379-1384 | Probing the Mechanisms of Drug Release from Hydroxypropylmethyl Cellulose Matrices | Anh Thu Pham and Ping I. Lee |
| 1385-1390 | Formulation and Intestinal Absorption Enhancement Evaluation of Water-in-Oil Microemulsions Incorporating Medium-Chain Glycerides | Panayiotis P. Constantinides, Jean-Paul Scalart, Cindy Lancaster, Joseph Marcello and Gary Marks, et al. |
| 1391-1395 | Dependence of Dissolution Rate on Surface Area: Is a Simple Linear Relationship Valid for Co-Compressed Drug Mixtures? | Seshadri Neervannan, Marylee Z. Southard and Valentine J. Stella |
| 1396-1400 | Vehicle Effects on in Vitro Percutaneous Absorption Through Rat and Human Skin | Jennifer Hilton, Bruce H. Woollen, Robert C. Scott, Timothy R. Auton and Kathryn L. Trebilcock, et al. |
| 1401-1404 | Decanoic Acid Induced Enhancement of Rectal Absorption of Hydrophilic Compounds in Rats | Koji Takahashi, Teruo Murakami, Ryoko Yumoto, Tomomi Hattori and Yutaka Higashi, et al. |
| 1405-1413 | Mechanism and Kinetics of Transcellular Transport of a New β-Lactam Antibiotic Loracarbef Across an Intestinal Epithelial Membrane Model System (Caco-2) | Ming Hu, Jiyue Chen, Yanping Zhu, Anne H. Dantzig and Robert E. Stratford, Jr, et al. |
| 1414-1418 | Organization of Stratum Corneum Lipids in Relation to Permeability: Influence of Sodium Lauryl Sulfate and Preheating | Christèle Ribaud, Jean-Claude Garson, Jean Doucet and Jean-Luc Lévêque |
| 1419-1423 | Follicular (Pilosebaceous Unit) Deposition and Pharmacological Behavior of Cimetidine as a Function of Formulation | Linda Margaret Lieb, Gordon Flynn and Norman Weiner |
| 1424-1428 | Relationship Between Enoxacin and Ciprofloxacin Plasma Concentrations and Theophylline Disposition | John D. Davis, Leon Aarons and J. Brian Houston |
| 1429-1434 | Comparative Pharmacokinetic and Pharmacodynamic Analysis of Phthaloyl Glycine Derivatives with Potential Antiepileptic Activity | Omar Abu Salach, Salim Hadad, Abdullah Haj-Yehia, Sherbel Sussan and Meir Bialer |
| 1435-1442 | Pharmacokinetic and Pharmacodynamic Aspects of an Ophthalmic Pilocarpine Nanoparticle-Delivery-System | Andreas Zimmer, Ernst Mutschler, Günter Lambrecht, Dieter Mayer and Jörg Kreuter |
| 1443-1447 | Renin Inhibitor: Relationship Between Molecular Structure and Oral Absorption | Naofumi Hashimoto, Toshihiro Fujioka, Kunio Hayashi, Kunihiro Odaguchi and Tatsuo Toyoda, et al. |
| 1448-1451 | Renin Inhibitor: Transport Mechanism in Rat Small Intestinal Brush-Border Membrane Vesicles | Naofumi Hashimoto, Toshihiro Fujioka, Tatsuo Toyoda, Noriyuki Muranushi and Koichiro Hirano |
| 1452-1457 | Interaction of Benzothiadiazides with Human Serum Albumin Studied by Dialysis and Spectroscopic Methods | Norito Takamura, Mohamed Habibur Rahman, Keishi Yamasaki, Michio Tsuruoka and Masaki Otagiri |
| 1458-1461 | Cyclosporin Absorption Is Impaired by the Fat Substitutes, Sucrose Polyester and Tricarballylate Triester, in the Rat | Kamel Benmoussa, Alain Sabouraud, Jean-Michel Scherrmann and Jean-Marie Bourre |
| 1462-1466 | A Bayesian Approach to Arrhenius Prediction of Shelf-Life | Xiang-Yao Su, Alain Li Wan Po and Sumie Yoshioka |
| 1467-1473 | The Effect of Bulking Agent on the Solid-State Stability of Freeze-Dried Methylprednisolone Sodium Succinate | Beth D. Herman, Brent D. Sinclair, Nathaniel Milton and Steven L. Nail |
| 1474-1478 | Processing Considerations for an EC Latex Coating System: Influence of Curing Time and Temperature | Dawn Hutchings, Barbara Kuzmak and Adel Sakr |
| 1479-1484 | Polylactide Microparticles Prepared by Double Emulsion/Evaporation Technique. I. Effect of Primary Emulsion Stability | Nicole Nihant, Chantal Schugens, Christian Grandfils, Robert Jérôme and Philippe Teyssié |
| 1485-1491 | Gamma Sterilization of a Semi-Solid Poly(ortho ester) Designed for Controlled Drug Delivery—Validation and Radiation Effects | Alain Merkli, Jorge Heller, Cyrus Tabatabay and Robert Gurny |
| 1492-1495 | Selective Precipitation of Interleukin-4 Using Hydrophobic Ion Pairing: A Method for Improved Analysis of Proteins Formulated with Large Excesses of Human Serum Albumin | Jeffrey D. Meyer, James E. Matsuura, James A. Ruth, Eli Shefter and Suman T. Patel, et al. |
| 1496-1500 | Effects of Various Protease Inhibitors on the Intestinal Absorption and Degradation of Insulin in Rats | Akira Yamamoto, Toshio Taniguchi, Kaori Rikyuu, Tomoko Tsuji and Takuya Fujita, et al. |
| 1501-1504 | Intestinal Permeability Enhancement: Structure-Activity and Structure-Toxicity Relationships for Nonylphenoxypolyoxyethylene Surfactant Permeability Enhancers | E. Scott Swenson, William B. Milisen and William Curatolo |
| 1505-1508 | A Simple Method of Correlating Pharmacodynamic Equivalence with Absolute Bioavailability Following Noninvasive Delivery of Insulin | Yuping Li and Ashim K. Mitra |
| 1509 | BOOK REVIEWS |
| 1510 | EIGHTH ANNUAL PHARMACOKINETICS COURSE FOR PHARMACEUTICAL SCIENTISTS ONE-WEEK WORKSHOP ON ADVANCED METHODS IN PHARMACOKINETICS |
| 1511-1515 | Hepatic Blood Flow Measurements and Indocyanine Green Kinetics in a Chronic Dog Model | Andrej Skerjanec, Darryl W. O’Brien and Yun K. Tam |
| 1516-1518 | Carrier-Mediated Transport of H1-Antagonist at the Blood-Brain Barrier: A Common Transport System of H1-Antagonists and Lipophilic Basic Drugs | Masahiro Yamazaki, Tetsuya Terasaki, Kuniaki Yoshioka, Osamu Nagata and Hideo Kato, et al. |
| 1519-1523 | Effect of Renal or Hepatic Dysfunction on Neurotoxic Convulsion Induced by Ranitidine in Mice | Masafumi Shimokawa, Koujirou Yamamoto, Junichi Kawakami, Yasufumi Sawada and Tatsuji Iga |
| 1524-1529 | First-Pass Effect of cis-3,4-Dichloro-N-methyl-N-(2-(l-pyrrolidinyl)-cyclohexyl)-benzamide (U-54494) in Rats— A Model with Multiple Cannulas for Investigation of Gastrointestinal and Hepatic Metabolism | Wei-Zhu Zhong, Marta G. Williams, Kathleen J. Cook, Terri L. VandeGiessen and Brian W. Jones, et al. |
| 1530-1534 | Pharmacokinetics of Intranasally-Administered Dihydroergotamine in the Rat | David T.-W. Lau, Zhiling Yu, Renee L. Aun, Alan E. Hassell and Francis L. S. Tse |
| 1535-1539 | Identification of the Diastereomers of Pentobarbital N-Glucosides Excreted in Human Urine | William H. Soine, Phyllis J. Soine, Terry M. England, Ruth M. Graham and Gerald Capps |
| 1540-1544 | The Influence of Net Water Absorption on the Permeability of Antipyrine and Levodopa in the Human Jejunum | Dag Nilsson, Urban Fagerholm and Hans Lennernäs |
| 1545-1548 | Quantitative Analysis of a Drug in an Animal Feed Employing Sample Preparation by Supercritical Fluid Extraction | Dale C. Messer, Larry T. Taylor, William E. Weiser, John W. McRae and Christopher C. Cook |
| 1549-1556 | Effects of Configuration Around the Chiral Carbon Atoms on the Crystal Properties of Ephedrinium and Pseudoephedrinium Salicylates | Sarma P. Duddu and David J. W. Grant |
| 1557-1561 | The Measurement of Mixture Homogeneity and Dissolution to Predict the Degree of Drug Agglomerate Breakdown Achieved Through Powder Mixing | Melgardt M. Villiers and Jakkie G. Watt |
| 1562-1567 | Properties of Free Films Prepared from Aqueous Polymers by a Spraying Technique | Sakae Obara and James W. McGinity |
| 1568-1574 | Development and Characterization of Microencapsulated Microspheres | Achim Göpferich, Maria Jose Alonso and Robert Langer |
| 1575-1580 | Transepithelial Transport and Metabolism of Thyrotropin-Releasing Hormone (TRH) in Monolayers of a Human Intestinal Cell Line (Caco-2): Evidence for an Active Transport Component? | Elke Walter and Thomas Kissel |
| 1581-1587 | Aggregation Pathway of Recombinant Human Keratinocyte Growth Factor and Its Stabilization | Bao-lu Chen, Tsutomu Arakawa, Charles F. Morris, William C. Kenney and Christina M. Wells, et al. |
| 1588-1592 | Preparation of Sterically Stabilized Human Serum Albumin Nanospheres Using a Novel Dextranox-MPEG Crosslinking Agent | Wu Lin, Allan G. A. Coombes, Martin C. Garnett, Martyn C. Davies and Etienne Schacht, et al. |
| 1593-1598 | In Vitro Cutaneous and Percutaneous Delivery and in Vivo Efficacy of Tetracaine from Liposomal and Conventional Vehicles | Marianna Foldvari |
| 1599-1604 | Intestinal Uptake of Cimetidine and Ranitidine in Rats | Vanaja Mummaneni and Jennifer B. Dressman |
| 1605-1609 | A New Bioerodible Polymer Insert for the Controlled Release of Metronidazole | Kimberly A. Gates, Helen Grad, Peter Birek and Ping I. Lee |
| 1610-1616 | Subzero Thermal Analysis of Human Stratum Corneum | Hanafi Tanojo, Joke A. Bouwstra, Hans E. Junginger and Harry E. Boddé |
| 1617-1622 | Effects of Protease Inhibitors on Vasopressin Transport Across Rat Alveolar Epithelial Cell Monolayers | Hiroshi Yamahara, Kazuhiro Morimoto, Vincent H. L. Lee and Kwang-Jin Kim |
| 1623-1630 | Nasal Absorption in the Rat. III. Effect of Lysophospholipids on Insulin Absorption and Nasal Histology | Susan G. Chandler, Norman W. Thomas and Lisbeth Illum |
| 1631-1639 | Dermal Microdialysis Sampling in Vivo | Joseph M. Ault, Christopher M. Riley, Noel M. Meltzer and Craig E. Lunte |
| 1640-1645 | Colonic Absorption and Bioavailability of the Pentapeptide Metkephamid in the Rat | Peter Langguth, Gerhard Breves, Arthur Stökli, Hans P. Merkle and Siegfried Wolffram |
| 1646-1651 | Kinetic Analysis of the Drug Permeation Process Across the Intestinal Epithelium | Shinji Yamashita, Masako Yoshida, Yoko Taki, Toshiyasu Sakane and Tanekazu Nadai |
| 1652-1656 | Antiinflammatory Drug-Induced Small Intestinal Permeability: The Rat Is a Suitable Model | Neal M. Davies, Matthew R. Wright and Fakhreddin Jamali |
| 1657-1662 | Transdermal Delivery of Metoprolol by Electroporation | Rita Vanbever, Nathalie Lecouturier and Véronique Préat |
| 1663-1668 | In Vitro and in Vivo Evaluation in Dogs and Pigs of a Hydrophilic Matrix Containing Propylthiouracil | Louis Kabanda, Romain Adelin Lefebvre, Henri Jacques Bree and Jean Paul Remon |
| 1669-1672 | Pharmacokinetics of Two Enteric-Coated Ketoprofen Products in Humans with or Without Coadministration of Omeprazole and Comparison with Dissolution Findings | Saeed A. Qureshi, Gilles Caillé, Yves Lacasse and Iain J. McGilveray |
| 1673-1676 | In Vitro Plasma Metabolism of RMP-7 | Julie Ann Straub, Alan Akiyama and Parul Parmar |
| 1677-1679 | Entrapping Efficiency of an Oil-in-Water Emulsion Containing Isocarbacyclin Methyl Ester (TEI-9090) in Dog and Human Sera | Toshiya Minagawa, Yoshiro Kohno, Toshio Suwa and Akira Tsuji |
| 1680 | EIGHTH ANNUAL PHARMACOKINETICS COURSE FOR PHARMACEUTICAL SCIENTISTS ONE-WEEK WORKSHOP ON ADVANCED METHODS IN PHARMACOKINETICS |
| 1681-1688 | Insulin Fragments as a Carrier for Peptide Delivery Across the Blood–Brain Barrier | Makoto Fukuta, Hiroaki Okada, Satoshi Iinuma, Shigeo Yanai and Hajime Toguchi |
| 1689-1697 | Transsynovial Drug Distribution: Synovial Mean Transit Time of Diclofenac and Other Nonsteroidal Antiinflammatory Drugs | William F. Elmquist, Keith K. H. Chan and Ronald J. Sawchuk |
| 1698-1703 | The Effect of Cyclodextrins on the Stability of Peptides in Nasal Enzymic Systems | William J. Irwin, Anil K. Dwivedi, Paula A. Holbrook and Michael J. Dey |
| 1704-1706 | Mechanism of Optical Isomerization of(S)-N-[1-(2-Fluorophenyl)-3,4,6,7-tetrahydro-4-oxopyrrolo[3,2,1-jk] [l,4]-benzodiazepine-3-y1]-1H-indole-2-carboxamide (FK480) in Soft Capsules Containing Polyethylene Glycol 400 and Glycerol | Shinichi Fukuyama, Noriaki Kihara, Keiichi Nakashima, Noritsugu Morokoshi and Shigetaka Koda, et al. |
| 1707-1711 | Menthol-β-D-Glucuronide: A Potential Prodrug for Treatment of the Irritable Bowel Syndrome | Harold W. Nolen III and David R. Friend |
| 1712-1720 | Aqueous Stability of Human Epidermal Growth Factor 1-48 | Richard I. Senderoff, Scott C. Wootton, Amal M. Boctor, Tsun Ming Chen and Anne B. Giordani, et al. |
| 1721-1725 | Is Stability Prediction Possible for Protein Drugs? Denaturation Kinetics of β- Galactosidase in Solution | Sumie Yoshioka, Yukio Aso, Ken-ichi Izutsu and S. Kojima |
| 1726-1730 | Natriuretic Peptide-Potentiating Actions of Neutral Endopeptidase Inhibition in Rats with Experimental Heart Failure | Masato Yasuhara, Masayuki Yamaguchi, Hiromasa Shimizu, Yukiya Hashimoto and Norio Hama, et al. |
| 1731-1736 | Targeted Gene Delivery to Alveolar Macrophages via Fc Receptor-Mediated Endocytosis | Yongyut Rojanasakul, Li Ying Wang, Carl J. Malanga, Joseph K. H. Ma and Jiahorng Liaw |
| 1737-1741 | The Relation Between Swelling Properties and Enzymatic Degradation of Azo Polymers Designed for Colon-Specific Drug Delivery | Guy Van den Mooter, Celest Samyn and Renaat Kinget |
| 1742-1746 | Effect of Current Magnitude and Drug Concentration on lontophoretic Delivery of Octreotide Acetate (Sandostatin®) in the Rabbit | David T.-W. Lau, John W. Sharkey, Lew Petryk, Frank A. Mancuso and Zhiling Yu, et al. |
| 1747-1754 | Improving the Sensitivity of in Vitro Skin Penetration Experiments | Gerald B. Kasting, Thomas G. Filloon, William R. Francis and Michael P. Meredith |
| 1755-1760 | The Effects of Bile Salts and Lipids on the Physicochemical Behavior of Gemfibrozil | Paul E. Luner, Suresh R. Babu and Galen W. Radebaugh |
| 1761-1765 | Characteristics of Ceftibuten Uptake into Caco-2 Cells | Noriyuki Muranushi, Kazutoshi Horie, Kazuyoshi Masuda and Koichiro Hirano |
| 1766-1770 | Effect of 2-Hydroxypropyl-β-cyclodextrin on Crystallization and Polymorphic Transition of Nifedipine in Solid State | Fumitoshi Hirayama, Zheng Wang and Kaneto Uekama |
| 1771-1776 | Comparison of the Transport Characteristics of D- and L-Methionine in a Human Intestinal Epithelial Model (Caco-2) and in a Perfused Rat Intestinal Model | Lixing Zheng, Jiyue Chen, Yanping Zhu, Hua Yang and William Elmquist, et al. |
| 1777-1784 | Transport of β-Estradiol in Freshly Excised Human Skin in Vitro: Diffusion and Metabolism in Each Skin Layer | Puchun Liu, William I. Higuchi, Abdel-Halim Ghanem and William R. Good |
| 1785-1791 | The Role of Rheological Properties in Mucociliary Transport by Frog Palate Ciliated Model | Danny M. Yu, Gordon L. Amidon, Norman D. Weiner, David Fleisher and Arthur H. Goldberg |
| 1792-1799 | Formation and Characterization of Cisplatin-Loaded Poly(benzyl 1-glutamate) Microspheres for Chemoembolization | Chun Li, David J. Yang, Sarah Nikiforow, Wayne Tansey and Li-Ren Kuang, et al. |
| 1800-1808 | Surface Modification of Poly(lactide-co-glycolide) Nanospheres by Biodegradable Poly(lactide)-Poly(ethylene glycol) Copolymers | Snjezana Stolnik, Susan E. Dunn, Martin C. Garnett, Martyn C. Davies and Allan G. A. Coombes, et al. |
| 1809-1814 | Effect of Electroporation on Transdermal lontophoretic Delivery of Luteinizing Hormone Releasing Hormone (LHRH) in Vitro | D. Bommi Bommannan, Janet Tamada, Lewis Leung and Russell O. Potts |
| 1815-1819 | Enantioselective Kinetics of Verapamil and Norverapamil in Isolated Perfused Rat Livers | Reza Mehvar, James M. Reynolds, Megan A. Robinson and James A. Longstreth |
| 1820-1824 | Effect of Perfusate pH on Reduction of Quinidine Capillary Permeability by Albumin in Isolated Perfused Rat Heart | Denis J. Morgan and Cao Ling Xu |
| 1825-1828 | The Use of Multiple Doses and Pharmacodynamic System Analysis to Distinguish Between Dispositional Delays and Time-Variant Pharmacodynamics | Marc R. Gastonguay and Sorell L. Schwartz |
| 1829-1833 | Effect of Substituted Benzoylglycines (Hippurates) and Phenylacetylglycines on p-Aminohippurate Transport in Dog Renal Membrane Vesicles | Frans G. M. Russel and Wim G. Vermeulen |
| 1834-1837 | Rapid Temporal Control of Transdermal Drug Delivery by Electroporation | Mark R. Prausnitz, Uwe Pliquett, Robert Langer and James C. Weaver |
| 1838-1841 | Author Index to Volume 11 (1994) |
| 1842-1845 | Subject Index to Volume 11 (1994) |
| 1847 | ERRATUM |
| 1 | EDITORIAL |
| 2-11 | Stability of Protein Formulations: Investigation of Surfactant Effects by a Novel EPR Spectroscopic Technique | Narendra B. Bam, Theodore W. Randolph and Jeffrey L. Cleland |
| 12-17 | Hepatic Uptake of Octreotide, a Long-Acting Somatostatin Analogue, via a Bile Acid Transport System | Tetsuya Terasaki, Hiroko Mizuguchi, Chizuru Itoho, Ikumi Tamai and Michel Lemaire, et al. |
| 18-23 | Vitamin K Prodrugs: 1. Synthesis of Amino Acid Esters of Menahydroquinone-4 and Enzymatic Reconversion to an Active Form | Jiro Takata, Yoshiharu Karube, Mitsunobu Hanada, Kazuhisa Matsunaga and Yoshikazu Matsushima, et al. |
| 24-38 | Investigation of 3,5-Isoxazolidinediones as Hypolipidemic Agents in Rodents | Tyrone Woodard, Manik L. Debnath, Rupendra Simlot, Robert A. Izydore and Dwayne L. Daniels, et al. |
| 39-48 | Structures of Nanoparticles Prepared from Oil-in-Water Emulsions | Brita Sjöström, Alon Kaplun, Yeshayahu Talmon and Bernard Cabane |
| 49-52 | Rates of Systemic Degradation and Reticuloendothelial System Uptake of Calcein in the Dipalmitoylphosphatidylcholine Liposomes with Soybean-Derived Sterols in Mice | Xian-rong Qi, Yoshie Maitani and Tsuneji Nagai |
| 53-59 | Some Factors Associated with the Ultrasonic Nebulization of Proteins | Ralph W. Niven, Anna Y. Ip, S. Mittelman, S. J. Prestrelski and T. Arakawa |
| 60-68 | Reversible Adsorption of Soluble Hexameric Insulin onto the Surface of Insulin Crystals Cocrystallized with Protamine: An Electrostatic Interaction | Steven W. Dodd, Henry A. Havel, Paul M. Kovach, Chitra Lakshminarayan and Martin P. Redmon, et al. |
| 69-77 | Surface Denaturation at Solid-Void Interface—A Possible Pathway by Which Opalescent Participates Form During the Storage of Lyophilized Tissue-Type Plasminogen Activator at High Temperatures | Chung C. Hsu, Hoc M. Nguyen, Douglas A. Yeung, Dennis A. Brooks and Gary S. Koe, et al. |
| 78-84 | Differential Effects of Sulfate and Sulfobutyl Ether of β-Cyclodextrin on Erythrocyte Membranes in Vitro | Kazufumi Shiotani, Keiko Uehata, Tetsumi Irie, Kaneto Uekama and Diane O. Thompson, et al. |
| 85-87 | Acute Renal Toxicity of Doxorubicin (Adriamycin)-Loaded Cyanoacrylate Nanoparticles | Luc Manil, Philippe Mahieu and Patrick Couvreur |
| 88-95 | A New Method for Estimating Dermal Absorption from Chemical Exposure: 2. Effect of Molecular Weight and Octanol-Water Partitioning | Annette L. Bunge and Robert L. Cleek |
| 96-102 | Aerosol Deposition as a Function of Airway Disease: Cystic Fibrosis | Ted Martonen, Ira Katz and William Cress |
| 103-107 | Evaluation of Different Metrics as Indirect Measures of Rate of Drug Absorption from Extended Release Dosage Forms at Steady-State | Cristos Reppas, Larry F. Lacey, Oliver N. Keene, Panos Macheras and Alan Bye |
| 108-112 | Penetration Kinetics of 2′,3′-Dideoxyinosine in Dermis Is Described by the Distributed Model | Elora Gupta, M. Guillaume Wientjes and Jessie L.-S. Au |
| 113-116 | Pharmacokinetics of Antimony in Patients Treated with Sodium Stibogluconate for Cutaneous Leishmaniasis | May Al laser, Adnan El-Yazigi and Simon L. Croft |
| 117-123 | Assessment of Toxicokinetics and Toxicodynamics Following Intravenous Administration of Etoposide Phosphate in Beagle Dogs | Linus N. Igwemezie, Sanjeev Kaul and Rashmi H. Barbhaiya |
| 124-128 | Applying Bailer's Method for AUC Confidence Intervals to Sparse Sampling | Jerry R. Nedelman, Ekaterina Gibiansky and David T. W. Lau |
| 129-133 | The Use of Intracerebral Microdialysis to Determine Changes in Blood-Brain Barrier Transport Characteristics | Elizabeth C. M. de Lange, Mayke B. Hesselink, Meindert Danhof, Albertus G. de Boer and Douwe D. Breimer |
| 134-137 | Assessment of Glucocorticoid Lung Targeting by ex-Vivo Receptor Binding Studies in Rats | Guenther Hochhaus, Ricardo J. Gonzalez-Rothi, Anatoly Lukyanov, Hartmut Derendorf and Hans Schreier, et al. |
| 138-143 | Sumatriptan Absorption from Different Regions of the Human Gastrointestinal Tract | Patricia E. Warner, Kirn L. R. Brouwer, Elizabeth K. Hussey, George E. Dukes and Karl H. Donn, et al. |
| 144-148 | Comparison of Simulated and in-Vivo Plasma Levels of Cilastatin Following Intravenous in-Line Drug Administration | Joseph Wong, Wei-Youh Kuu, Ronald Burke, Robert Johnson and Ray W. Wood |
| 149-154 | Evaluation of the Intestinal Absorption of Erythromycin in Man: Absolute Bioavailability and Comparison with Enteric Coated Erythromycin | Andrew A. Somogyi, Felix Bochner, David Hetzel and Desmond B. Williams |
| 155-160 | Determination of Aliphatic Thiols by Fluorometric High-Performance Liquid Chromatography After Precolumn Derivatization with 2-(4-N-Maleimidophenyl)-6-Methylbenzothiazole | Abdullah I. Haj-Yehia and Leslie Z. Benet |
| 161-163 | Determination of Moisture in Intact Gelatin Capsules by Near-Infrared Spectrophotometry | Robert G. Buice, Jr, Thomas B. Gold, Robert A. Lodder and George A. Digenis |
| 164-167 | Metabolism of Acetylneurotensin(8–13) by Proteolytic Activities of Intestinal Enterocytes | Jane P. F. Bai and Li-Ling Chang |
| 168-170 | The Influence of the Shape of the Plasma Drug Concentration Profile upon the Pharmacological Effect | Mark Knowles and Stephen S. Hwang |
| 171-175 | Cultured Human Sweat Gland Epithelia: Isolation of Glands Using Neutral Red | David J. Brayden and Joan Fitzpatrick |
| 176 | BOOK REVIEWS |
| 177 | EDITORIAL |
| 179-186 | Transfollicular Drug Delivery | Andrea C. Lauer, Linda M. Lieb, C. Ramachandran, Gordon L. Flynn and Norman D. Weiner |
| 187-191 | Synthesis and Pharmacological Properties of 2-[S-Acetylthiorphan]-l,3-diacylaminopropan-2-ol Derivatives as Chimeric Lipid Drug Carriers Containing an Enkephalinase Inhibitor | Didier M. Lambert, Frank Mergen, Catherine F. Berens, Jacques H. Poupaert and Pierre Dumont |
| 192-195 | Physical Entrapment of Adriamycin in AB Block Copolymer Micelles | Glen S. Kwon, Mayumi Naito, Masayuki Yokoyama, Teruo Okano and Yasuhisa Sakurai, et al. |
| 196-200 | Construction of an Intermittent-Motion Capsule Filling Machine Simulator | Jeffrey R. Britten, Michael I. Barnett and N. Anthony Armstrong |
| 201-208 | Preparation and Physicochemical Characterization of Aqueous Dispersions of Coenzyme Q10 Nanoparticles | Britta Siekmann and Kirsten Westesen |
| 209-214 | Design for Cell-Specific Targeting of Proteins Utilizing Sugar-Recognition Mechanism: Effect of Molecular Weight of Proteins on Targeting Efficiency | Makiya Nishikawa, Hideki Hirabayashi, Yoshinobu Takakura and Mitsuru Hashida |
| 215-222 | Stabilization of Chimeric BR96-Doxorubicin Immunoconjugate | Nancy P. Barbour, Mehdi Paborji, Thomas C. Alexander, William P. Coppola and Joseph B. Bogardus |
| 223-230 | Efficacy Evaluation of a Novel Submicron Miconazole Emulsion in a Murine Cryptococcosis Model | Menashe Y. Levy, Itzhack Polacheck, Yechezkel Barenholz and Simon Benita |
| 231-236 | Comparison of Gamma Scintigraphy and a Pharmacokinetic Technique for Assessing Pulmonary Deposition of Terbutaline Sulphate Delivered by Pressurized Metered Dose Inhaler | Stephen Newman, Karen Steed, Gerard Hooper, Anders Källén and Lars Borgström |
| 237-243 | Estimation of Agitation Intensity in the GI Tract in Humans and Dogs Based on in Vitro/in Vivo Correlation | Noriko Katori, Nobuo Aoyagi and Tadao Terao |
| 244-247 | In Vivo Evaluation of a Colon-Specific Drug Delivery System: An Absorption Study of Theophylline from Capsules Coated with Azo Polymers in Rats | Guy Mooter, Celest Samyn and Renaat Kinget |
| 248-256 | Drug Transport Across Nylon 610 Films: Influence of Synthesis Variables | Kenneth Phares, Moo Cho, Keith Johnson and James Swarbrick |
| 257-262 | Effect of Norfloxacin on Theophylline Disposition: A Comparison with Other Fluoroquinolones | John D. Davis, Leon Aarons and J. Brian Houston |
| 263-269 | Incorporation of First-Order Uptake Rate Constants from Simple Mammillary Models into Blood-Flow Limited Physiological Pharmacokinetic Models via Extraction Efficiencies | William L. Roth, L. W. D. Weber and Karl K. Rozman |
| 270-274 | Pharmacokinetic Study of Zeolite A, Sodium Aluminosilicate, Magnesium Silicate, and Aluminum Hydroxide in Dogs | Eugenio A. Cefali, Joseph C. Nolan, William R. McConnell and Denise Lowe Walters |
| 275-283 | Comparative Tissue Distribution and Elimination of Amphotericin B Colloidal Dispersion (Amphocil®) and Fungizone® After Repeated Dosing in Rats | Laurence H. Wang, Robert M. Fielding, Philip C. Smith and Luke S. S. Guo |
| 284-290 | Age-Dependent Intestinal Absorption of Valproic Acid in the Rat | Allen Cato III, Gary M. Pollack and Kim L. R. Brouwer |
| 291-294 | Microdialysis Sampling to Determine the Pharmacokinetics of Unbound SDZ ICM 567 in Blood and Brain in Awake, Freely-Moving Rats | Maria J. Alonso, Armin Bruelisauer, Pierrette Misslin and Michel Lemaire |
| 295-298 | Estimation of Impurity Profiles of Drugs and Related Materials. 12. Isolation and Identification of an Isomeric Impurity in Danazol | Gábor Balogh, Éva Csizér, György G. Ferenczy, Zsuzsanna Halmos and Bulcsu Herényi, et al. |
| 299-304 | Changes in Solid-State Structure of Cyclophosphamide Monohydrate Induced by Mechanical Treatment and Storage | Jarkko Ketolainen, Antti Poso, Veijo Viitasaari, Jukka Gynther and Jukka Pirttimäki, et al. |
| 305-308 | Chemical Pathways of Degradation of the Bradykinin Analog, RMP-7 | Julie Ann Straub, Alan Akiyama, Parul Parmar and Gary F. Musso |
| 309-312 | Differential Expression of the Phenol Family of UDP-Glucuronosyltransferases in Hepatoma Cell Lines | Ah-Ng Tony Kong, Peiwen Fei and Bradley K. Wong |
| 313-316 | Pharmacokinetics of Caffeine and Its Demethylated Metabolites in Lactation: Predictions of Milk to Serum Concentration Ratios | Cheah Y. Oo, David E. Burgio, Robert C. Kuhn, Nirmala Desai and Patrick J. McNamara |
| 317-319 | Structural Requirements for Interaction with the Oligopeptide Transporter in Caco-2 Cells | Ismael J. Hidalgo, Pradip Bhatnagar, Chao-Pin Lee, Joanne Miller and Gregory Cucullino, et al. |
| 320-321 | Reviewers for Pharmaceutical Research (January 1, 1994 - November 30, 1994) |
| 322 | European Reviewers for Pharmaceutical Research (January 1, 1994 - November 23, 1994) |
| 323-328 | The Importance of Structural Factors on the Rate and the Extent of N,O-acyl Migration in Cyclic and Linear Peptides | Reza Oliyai, Teruna J. Siahaan and Valentine J. Stella |
| 329-336 | Soft Drugs. XX. Design, Synthesis, and Evaluation of Ultra-Short Acting Beta-Blockers | Hee-Sun Yang, Whei-Mei Wu and Nicholas Bodor |
| 337-341 | Crystal Structure of 2-Debenzoyl, 2-Acetoxy Paclitaxel (Taxol®): Conformation of the Paclitaxel Side-Chain | Qi Gao, Jian-Mei Wei and Shu-Hui Chen |
| 342-347 | Physicochemical Characterization of Parenteral Lipid Emulsion: Determination of Hamaker Constants and Activation Energy of Coalescence | Tetsuo Yamaguchi, Kaori Nishizaki, Shigeru Itai, Hidefumi Hayashi and Hiroyuki Ohshima |
| 348-355 | Chemical Pathways of Peptide Degradation. VIII. Oxidation of Methionine in Small Model Peptides by Prooxidant/Transition Metal Ion Systems: Influence of Selective Scavengers for Reactive Oxygen Intermediates | Shihong Li, Christian Schöneich and Ronald T. Borchardt |
| 356-359 | The Influence of Regional Deposition on the Pharmacokinetics of Pulmonary-Delivered Human Growth Hormone in Rabbits | Paul Colthorpe, Stephen J. Fair, Ian J. Smith, David Wyatt and Glyn Taylor |
| 360-365 | Transepithelial Transport Properties of Peptidomimetic Thrombin Inhibitors in Monolayers of a Human Intestinal Cell Line (Caco-2) and Their Correlation to in Vivo Data | Elke Walter, Thomas Kissel, Martin Reers, Gerhard Dickneite and Dieter Hoffmann, et al. |
| 366-369 | A Non-Ionic Vesicle Lipid Enhances Mastoparan-Stimulated GTPase Activity of Heterotrimeric G-Proteins | Bernd Nürnberg, Ralph Hoppe, Ulrich Rümenapp, Rainer Harhammer and Eberhard Nürnberg |
| 370-375 | Tumor Selective Effect of RS-1541 (Palmitoyl-Rhizoxin) in M5076 Sarcoma and Host Tissues in Vivo | Taro Tokui, Naoyuki Maeda, Chitose Kuroiwa, Kazuhiko Sasagawa and Takashi Inoue, et al. |
| 376-379 | The Description of the Gastrointestinal Transit of Pellets Assessed by Gamma Scintigraphy Using Statistical Moments | Fridrun Podczeck, John Michael Newton and Kay-Hay Yuen |
| 380-386 | The Application of Malononitriles as Microviscosity Probes in Pharmaceutical Systems | Sherry L. LaPorte, Abizer Harianawala and Robin H. Bogner |
| 387-392 | Drug Delivery Studies in Caco-2 Monolayers. Synthesis, Hydrolysis, and Transport of O-Cyclopropane Carboxylic Acid Ester Prodrugs of Various β-Blocking Agents | Lars Hovgaard, Helle Brøndsted, Anders Buur and Hans Bundgaard |
| 393-396 | The Effect of Different Concentrations of Mannitol in Solution on Small Intestinal Transit: Implications for Drug Absorption | Dawn A. Adkin, Stanley S. Davis, Robert A. Sparrow, Paul D. Huckle and Anthony J. Phillips, et al. |
| 397-405 | In Vitro and in Vivo Evaluation of Mucoadhesive Microspheres Prepared for the Gastrointestinal Tract Using Polyglycerol Esters of Fatty Acids and a Poly(acrylic acid) Derivative | Yohko Akiyama, Naoki Nagahara, Toshio Kashihara, Shinichiro Hirai and Hajime Toguchi |
| 406-412 | Neural Network Predicted Peak and Trough Gentamicin Concentrations | Michael E. Brier, Jacek M. Zurada and George R. Aronoff |
| 413-420 | A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability | Gordon L. Amidon, Hans Lennernäs, Vinod P. Shah and John R. Crison |
| 421-425 | Analysis of Tissue Distribution of Valproate in Guinea-Pigs: Evidence for Its Capacity-Limited Tissue Distribution | Hsiu-Ying Yu and Yu-Zen Shen |
| 426-432 | Regional Rectal Perfusion: A New in Vivo Approach to Study Rectal Drug Absorption in Man | Hans Lennernäs, Urban Fagerholm, Yngve. Raab, Bengt Gerdin and Roger Hällgren |
| 433-437 | A Compartmental Model for the Ocular Pharmacokinetics of Cyclosporine in Rabbits | Clifford Oh, Bradley A. Saville, Yu-Ling Cheng and David S. Rootman |
| 438-445 | Pharmacodynamic Analysis of Analgesic Clinical Trials Using Empirical Methods | Chui Yu Liu and Nancy C. Sambol |
| 446-450 | Second Derivative Infrared Spectroscopy as a Non-Destructive Tool to Assess the Purity and Structural Integrity of Proteins | D. Michael Byler, Rachel M. Wilson, Cynthia S. Randall and Theodore D. Sokoloski |
| 451-454 | Stabilization of Human Epidermal Growth Factor (hEGF) in Aqueous Formulation | Kyonghee Son and Changhyuk Kwon |
| 455-458 | Functional Evaluation of Anchored Skin Equivalent Cultured in Vitro: Percutaneous Absorption Studies and Lipid Analysis | Martine Michel, Lucie Germain, Pierre Maxime Bélanger and François A. Auger |
| 459-463 | Pharmacodynamic Modeling of Prednisolone Effects on Natural Killer Cell Trafficking | Zhi-Xin Xu, Mi-Jeong Lee, Robert A. Blum and William J. Jusko |
| 465-483 | Antigene, Ribozyme and Aptamer Nucleic Acid Drugs: Progress and Prospects | Robert A. Stull and Francis C. Szoka, Jr |
| 484-490 | Thermal Analysis of the Tertiary Butyl Alcohol-Water System and Its Implications on Freeze-Drying | Kasra Kasraian and Patrick P. DeLuca |
| 491-495 | The Effect of Tertiary Butyl Alcohol on the Resistance of the Dry Product Layer During Primary Drying | Kasra Kasraian and Patrick P. DeLuca |
| 496-507 | Physico-Mechanical Characterization of the Extrusion-Spheronization Process. Part II: Rheological Determinants for Successful Extrusion and Spheronization | Rajen D. Shah, Mohan Kabadi, David G. Pope and Larry L. Augsburger |
| 508-512 | Monosialoganglioside GMl Shortens the Blood Circulation Time of Liposomes in Rats | Dexi Liu, Feng Liu and Young K. Song |
| 513-517 | Insulin-Degrading Enzyme in a Human Colon Adenocarcinoma Cell Line (Caco-2) | Jane P. F. Bai, Matt J. P. Hsu and W. Thomas Shier |
| 518-522 | Is the Beneficial Effect of Calcium Channel Blockers Against Cyclosporine A Toxicity Related to a Restoration of ATP Synthesis? | Marie D. Salducci, Anne M. Chauvet-Monges, Bertrand M. Dussol, Yvon F. Berland and Aimé D. Crevat |
| 523-528 | Characterization of Drug Transport Through Tight-Junctional Pathway in Caco-2 Monolayer: Comparison with Isolated Rat Jejunum and Colon | Yoshihiro Tanaka, Yoko Taki, Toshiyasu Sakane, Tanekazu Nadai and Hitoshi Sezaki, et al. |
| 529-533 | Ocular Absorption and Irritation of Pilocarpine Prodrug Is Modified with Buffer, Polymer, and Cyclodextrin in the Eyedrop | Pekka Suhonen, Tomi Järvinen, Kari Lehmussaari, Timo Reunamäki and Arto Urtti |
| 534-540 | Evaluation of Poly(isobutylcyanoacrylate) Nanoparticles for Mucoadhesive Ocular Drug Delivery. I. Effect of Formulation Variables on Physicochemical Characteristics of Nanoparticles | Sudip K. Das, Ian G. Tucker, David J. T. Hill and Nandita Ganguly |
| 541-548 | Carrier-Mediated Transport Can Obey Fractal Kinetics | Panos Macheras |
| 549-555 | Measurement of Rapid Release Kinetics for Drug Delivery | Uwe Pliquett, Mark R. Prausnitz, Yuri A. Chizmadzhev and James C. Weaver |
| 556-559 | Effect of Humidity-Dependent Changes in Crystal Structure on the Solid-State Fluorescence Properties of a New HMG-CoA Reductase Inhibitor | Harry G. Brittain, Sunanda A. Ranadive and Abu T. M. Serajuddin |
| 560-564 | Effects of Inclusion Complexation on the Transepithelial Transport of a Lipophilic Substance in Vitro | M. J. Cho, F. J. Chen and Dennis L. Huczek |
| 565-571 | Development of a Human Nasal Epithelial Cell Culture Model and Its Suitability for Transport and Metabolism Studies Under in Vitro Conditions | Ute Werner and Thomas Kissel |
| 572-575 | Use of ATR-FTIR Spectroscopy to Study the Diffusion of Ethanol Through Glycerogelatin Films | A. Margarida L. Tralhão, Adam C. Watkinson, Keith R. Brain, Jonathan Hadgraft and N. Anthony Armstrong |
| 576-582 | In Vitro Evaluation of Polymerized Liposomes as an Oral Drug Delivery System | Jun'ichi Okada, Smadar Cohen and Robert Langer |
| 583-587 | QSAR Analysis of Skin Permeability of Various Drugs in Man as Compared to in Vivo and in Vitro Studies in Rodents | Eric J. Lien and Hua Gaot |
| 588-593 | The in Vitro Characterization and Biostability of 99mTc-Dextran and Its Accumulation Within the Inflamed Paws of Adjuvant-Induced Arthritic Rats | Ian W. Kellaway, Lisa Seale and Paul S. J. Spencer |
| 594-598 | Relationship Between the Phasic Period of Interdigestive Migrating Contraction and the Systemic Bioavailability of Acetaminophen in Dogs | Kazuyoshi Sagara, Hiroaki Mizuta, Minoru Ohshiko, Masahiro Shibata and Keiichiro Haga |
| 599-604 | Isothermal and Nonisothermal Decomposition of Famotidine in Aqueous Solution | Gunjan H. Junnarkar and Salomon Stavchansky |
| 605-608 | Transport Mechanism of Ceftibuten, a Dianionic Cephem, in Rat Renal Brush-Border Membrane | Imad Naasani, Mitsuru Sugawara, Michiya Kobayashi, Ken Iseki and Katsumi Miyazaki |
| 609-614 | Metabolism of Diltiazem in Hepatic and Extrahepatic Tissues of Rabbits: InVitro Studies | Walid Homsy, Marc Lefebvre, Gilles Caillé and Patrick du Souich |
| 615-620 | A Cellular Automata Model of the Hydrophobia Effect | Lemont B. Kier, Chao-Kun Cheng, Bernard Testa and Pierre-Alain Carrupt |
| 621-629 | A Solution Conformation Analysis of Forocidins I and Isoforocidins I Using NMR and Molecular Modeling | Kumar Ramu, Sachin Shringarpure and John S. Williamson |
| 630-633 | Amoebicidal in Vitro Activity Shown by Some Metronidazole Analogues: Biological Response-Reduction Potential Correlation | Ma. Elena Campos, Marco Meraz, Hugo Sánchez and Héctor Salgado-Zamora |
| 634-635 | Solution Properties of Two Fluoroquinolone Antibacterials | Richard J. Prankerd |
| 637-641 | The Effect of pH and Temperature on the Self-Association of Recombinant Human Interleukin-2 as Studied by Equilibrium Sedimentation | Siddharth J. Advant, Emory H. Braswell, C. Vijaya Kumar and Devendra S. Kalonia |
| 642-648 | Interdomain Interactions in the Chimeric Protein Toxin sCD4(178)-PE40: A Differential Scanning Calorimetry (DSC) Study | Stephen R. Davio, Kathryn M. Kienle and Brian E. Collins |
| 649-652 | Primary Interactions of Three Quaternary Ammonium Compounds with Blastospores of Candida albicans (MEN Strain) | Leo J. Schep, David S. Jones and Max G. Shepherd |
| 653-657 | Antitumor Effect of Arterial Administration of a Medium-Chain Triglyceride Solution of an Angiogenesis Inhibitor, TNP-470, in Rabbits Bearing VX-2 Carcinoma | Shigeo Yanai, Hiroaki Okada, Kazuhiro Saito, Yuji Kuge and Masafumi Misaki, et al. |
| 658-662 | Selective Inhibition of Bitter Taste of Various Drugs by Lipoprotein | Yoshihisa Katsuragi, Yoko Sugiura, Cao Lee, Kazuya Otsuji and Kenzo Kurihara |
| 663-668 | Prolonged Blood Circulation in Rats of Nanospheres Surface-Modified with Semitelechelic Poly[N-(2-Hydroxypropyl)methacrylamide] | Shigeru Kamei and Jindřich Kopeček |
| 669-675 | Modelling Mucoadhesion by Use of Surface Energy Terms Obtained from the Lewis Acid–Lewis Base Approach. II. Studies on Anionic, Cationic, and Unionisable Polymers | Maria Rillosi and Graham Buckton |
| 676-681 | Autoradiographic Imaging of the Distribution of 5-Fluorouracil Through Cervical Tissue Following in Vitro Surface Application of a Bioadhesive Cervical Patch | A. David Woolfson, Dermot F. McCafferty, Paul A. McCarron and John H. Price |
| 682-686 | Interaction Between Bile Salts and β-Adrenoceptor Antagonists | Martin P. Grosvenor and Jan-Erik Löfroth |
| 687-692 | Enhanced Transdermal Delivery of Diazepam by Submicron Emulsion (SME) Creams | Joseph S. Schwarz, Michael R. Weisspapir and Doron I. Friedman |
| 693-699 | Comparison of Intestinal Permeabilities Determined in Multiple in Vitro and inSitu Models: Relationship to Absorption in Humans | Barbra H. Stewart, O. Helen Chan, Rosalind H. Lu, Eric L. Reyner and Heidi L. Schmid, et al. |
| 700-708 | The Role of Metabolites in Bioequivalency Assessment. II. Drugs with Linear Pharmacokinetics and First-Pass Effect | Mei-Ling Chen and Andre J. Jackson |
| 709-714 | Monoclonal Digoxin-Specific Antibodies Induce Dose-and Affinity-Dependent Plasma Digoxin Redistribution in Rats | Nathalie J. Cano, Alain E. Sabouraud, Kamel Benmoussa, Francoise Roquet and Isabelle Navarro-Teulon, et al. |
| 715-719 | The Distribution of Oleic Acid Between Salbutamol Base Drug and Different Propellant Blends | Patrik M. Eriksson, Kenneth B. Sandström and Jarl B. Rosenholm |
| 720-728 | Pharmacokinetics of Oral Extended-Release Dosage Forms. I. Release Kinetics, Concentration, and Absorbed Fraction | Fang-Yu Liu, Nancy C. Sambol, Robert P. Giannini and Chui Yu Liu |
| 729-737 | Experimental Design and Efficient Parameter Estimation in Preclinical Pharmacokinetic Studies | Ene I. Ette, Catherine A. Howie, Andrew W. Kelman and Brian Whiting |
| 738-745 | Gradient High Performance Liquid Chromatographic Assay for Degradation Products of Adinazolam Mesylate in a Sustained Release Tablet Formulation | Nick L. Stemm, John W. Skoug and Russell H. Robins |
| 746-750 | Quantitative Microdialysis for Studying the in Vivo L-DOPA Kinetics in Blood and Skeletal Muscle of the Dog | Sophie Sarre, Dirk Deleu, Kristel Van Belle, Guy Ebinger and Yvette Michotte |
| 751-755 | The Electrophoretic Mobility of Tripeptides as a Function of pH and Ionic Strength: Comparison with lontophoretic Flux Data | Barbara VanOrman Huff, Gary G. Liversidge and Gregory L. McIntire |
| 756-762 | Analysis of Diclofenac and Four of Its Metabolites in Human Urine by HPLC | Ronald J. Sawchuk, Jill A. Maloney, Linda L. Cartier, Russell J. Rackley and Keith K. H. Chan, et al. |
| 763-767 | Prodrugs to Improve the Oral Bioavailability of a Diacidic Nonpeptide Angiotensin II Antagonist | Bruce J. Aungst, Judy A. Blake, Nancy J. Rogers, Hiroshi Saitoh and Munir A. Hussain, et al. |
| 768-772 | Electrolyte-Induced Changes in Glass Transition Temperatures of Freeze-Concentrated Solutes | Lih-Min Her, Michael Deras and Steven L. Nail |
| 773-779 | Process-Induced Crystallinity Changes in Albuterol Sulfate and Its Effect on Powder Physical Stability | Gary H. Ward and Robert K. Schultz |
| 780-786 | Gastric pH Influences the Appearance of Double Peaks in the Plasma Concentration-Time Profiles of Cimetidine After Oral Administration in Dogs | Vanaja Mummaneni, Gordon L. Amidon and Jennifer B. Dressman |
| 787-789 | Drug Release from Semisolids: Effect of Membrane Permeability on Sensitivity to Product Parameters | Joel L. Zatz |
| 790-795 | Model Features of a Cardiac lontophoretic Drug Delivery Implant | Steven P. Schwendeman, Vinod Labhasetwar and Robert J. Levy |
| 796-798 | Dose-Dependent Brain Delivery of Zidovudine Through the Use of a Zidovudine Chemical Delivery System | Marcus E. Brewster, Wesley R. Anderson, Danny O. Helton, Nicholas Bodor and Emil Pop |
| 799-806 | Molecular Mobility of Amorphous Pharmaceutical Solids Below Their Glass Transition Temperatures | Bruno C. Hancock, Sheri L. Shamblin and George Zografi |
| 807-816 | Human Insulin Receptor Monoclonal Antibody Undergoes High Affinity Binding to Human Brain Capillaries in Vitro and Rapid Transcytosis Through the Blood–Brain Barrier in Vivo in the Primate | William M. Pardridge, Young-Sook Kang, Jody L. Buciak and Jing Yang |
| 817-824 | Radiolabeling of Methylphosphonate and Phosphorothioate Oligonucleotides and Evaluation of Their Transport in Everted Rat Jejunum Sacs | Jeffrey A. Hughes, Anna V. Avrutskaya, Kim L. R. Brouwer, Eric Wickstrom and R. L. Juliano |
| 825-830 | The Fate of Plasmid DNA After Intravenous Injection in Mice: Involvement of Scavenger Receptors in Its Hepatic Uptake | Kenji Kawabata, Yoshinobu Takakura and Mitsuru Hashida |
| 831-837 | Development of an Efficient Single-Step Freeze-Drying Cycle for Protein Formulations | Byeong S. Chang and Norman L. Fischer |
| 838-843 | Increased Stabilizing Effects of Amphiphilic Excipients on Freeze-Drying of Lactate Dehydrogenase (LDH) by Dispersion into Sugar Matrices | Ken-ichi Izutsu, Sumie Yoshioka and Shigeo Kojima |
| 844-850 | Comprehensive Pharmacokinetics of Urinary Human Follicle Stimulating Hormone in Healthy Female Volunteers | J.-Y. le Cotonnec, H. C. Porchet, V. Beltrami, A. Khan and S. Toon, et al. |
| 851-856 | Gamma Irradiation Effects on Molecular Weight and in Vitro Degradation of Poly(D,L-Lactide-CO-Glycolide) Microparticles | Angela G. Hausberger, Richard A. Kenley and Patrick P. DeLuca |
| 857-863 | Controlled Release of a Contraceptive Steroid from Biodegradable and Injectable Gel Formulations: In Vitro Evaluation | Zhi-Hui Gao, Atul J. Shukla, James R. Johnson and William R. Crowley |
| 864-868 | Controlled Release of Contraceptive Steroids from Biodegradable and Injectable Gel Formulations: In Vivo Evaluation | Zhi-hui Gao, William R. Crowley, Atul J. Shukla, James R. Johnson and James F. Reger |
| 869-874 | Soft Drugs 18. Oral and Rectal Delivery of Loteprednol Etabonate, a Novel Soft Corticosteroid, in Rats—for Safer Treatment of Gastrointestinal Inflammation | Nicholas Bodor, Teruo Murakami and Whei-Mei Wu |
| 875-879 | Soft Drugs 19. Pharmacokinetics, Metabolism and Excretion of a Novel Soft Corticosteroid, Loteprednol Etabonate, in Rats | Nicholas Bodor, Whei-Mei Wu, Teruo Murakami and Steven Engel |
| 880-883 | Evaluation of Intestinal Absorption into the Portal System in Enterohepatic Circulation by Measuring the Difference in Portal–Venous Blood Concentrations of Diclofenac | Kenji Tabata, Kiyoshi Yamaoka, Takako Fukuyama and Terumichi Nakagawa |
| 884-888 | Regiospecific Intestinal Absorption of the HIV Protease Inhibitor L-735,524 in Beagle Dogs | Gloria Y. Kwei, Linda B. Novak, Lisa A. Hettrick, Elisabeth R. Reiss and Drazen Ostovic, et al. |
| 889-894 | Method to Estimate the Rate and Extent of Intestinal Absorption in Conscious Rats Using an Absorption Probe and Portal Blood Sampling | Daniel J. Hoffman, Terese Seifert, Anthony Borre and Hugh N. Nellans |
| 895-901 | Interspecies Scaling of Tebufelone Pharmacokinetic Data and Application to Preclinical Toxicology | Charles A. Cruze, Gary R. Kelm and Michael P. Meredith |
| 902-904 | Effect of Corticosteroid Binding Globulin on the Pharmacokinetics of Prednisolone in Rats | Hui C. Ko, Richard R. Almon and William J. Jusko |
| 905-910 | Pharmacokinetic Analysis and Antiepileptic Activity of N-Valproyl Derivatives of GABA and Glycine | Salim Hadad and Meir Bialer |
| 911-915 | Comparative Brain Exposure to (-)-Carbovir After (-)-Carbovir or (-)-6-Aminocarbovir Intravenous Infusion in Rats | Yan-Dong Wen, Rory P. Remmel, Phuong T. Pham, Robert Vince and Cheryl L. Zimmerman |
| 916-922 | Effect of Liposomal and Free Bisphosphonates on the IL-1β, IL-6 and TNFα Secretion from RAW 264 Cells in Vitro | Niina Pennanen, Seppo Lapinjoki, Arto Urtti and Jukka Mönkkönen |
| 923-929 | The Effect of Moisture on the Mechanical and Powder Flow Properties of Microcrystalline Cellulose | Gregory E. Amidon and Michael E. Houghton |
| 930-936 | 5-Bromomethyl Fluorescein (5-BMF) for Derivatization of Carboxyl Containing Analytes for Use with Laser-Induced Fluorescence Detection | Partha S. Mukherjee, Kapila H. DeSilva and H. Thomas Karnes |
| 937-942 | Without Extrapolation, Cmax/AUC is an Effective Metric in Investigations of Bioequivalence | Laszlo Tothfalusi and Laszlo Endrenyi |
| 943-944 | Patient-Oriented Pharmaceutical Research: Focus on the Individual | Gerhard Levy |
| 945-954 | Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations | Stephen Byrn, Ralph Pfeiffer, Michael Ganey, Charles Hoiberg and Guirag Poochikian |
| 955-964 | Diffusion in HPMC Gels. I. Determination of Drug and Water Diffusivity by Pulsed-Field-Gradient Spin-Echo NMR | Ping Gao and Paul E. Fagerness |
| 965-971 | Diffusion in HPMC Gels. II. Prediction of Drug Release Rates from Hydrophilic Matrix Extended-Release Dosage Forms | Ping Gao, Phillip R. Nixon and John W. Skoug |
| 972-982 | A New Method for Estimating Dermal Absorption from Chemical Exposure. 3. Compared with Steady-State Methods for Prediction and Data Analysis | Annette L. Bunge, Robert L. Cleek and Brent E. Vecchia |
| 983-992 | Evaluation of Retinoid Lactones as Topical Therapeutic Agents in Dermatology | Anita H. Lewin, Sherry L. Black, Mary E. Bos, R. Richard Goehring and Xina Nair, et al. |
| 993-997 | In Vitro Percutaneous Absorption of Arildone, a Highly Lipophilic Drug, and the Apparent No-Effect of the Penetration Enhancer Azone in Excised Human Skin | E. J. Baker and J. Hadgraft |
| 998-1002 | Mechanisms Involved in lontophoretic Transport of Angiotensin | Martine Clemessy, Guy Couarraze, Bruno Bevan and Francis Puisieux |
| 1003-1010 | A New Large-Scale Process for Taxol and Related Taxanes from Taxusbrevifolia | Koppaka V. Rao, Jampani B. Hanuman, Claudio Alvarez, Mark Stoy and John Juchum, et al. |
| 1011-1018 | Characterization of Alkylating Versus Intercalating Anticancer Drug-Induced Effects on Cell Survival, Cell Cycle Kinetic and Morphonuclear Pattern of Three Neoplastic Cells Lines Growing in Vitro | Olivier Pauwels, Robert Kiss, Jean-Lambert Pasteels and Ghanem Atassi |
| 1019-1024 | Distribution, Metabolism and Tumoricidal Activity of Doxorubicin Administered in Sorbitan Monostearate (Span 60) Niosomes in the Mouse | Ijeoma F. Uchegbu, John A. Double, John A. Turton and Alexander T. Florence |
| 1025-1030 | Development of a Flow Microcalorimetry Method for the Assessment of Surface Properties of Powders | P. Louise Sheridan, Graham Buckton and David E. Storey |
| 1031-1039 | The Effect of Particle Fragmentation and Deformation on the Interparticulate Bond Formation Process During Powder Compaction | Maria Eriksson and Göran Alderborn |
| 1040-1044 | Improved Static Compression Behaviors and Tablettabilities of Spherically Agglomerated Crystals Produced by the Spherical Crystallization Technique with a Two-Solvent System | Yoshiaki Kawashima, Fude Cui, Hirofumi Takeuchi, Toshiyuki Niwa and Tomoaki Hino, et al. |
| 1045-1048 | Compressed Donut-Shaped Tablets with Zero-Order Release Kinetics | Cherng-ju Kim |
| 1049-1054 | Oral Solid Controlled Release Dosage Forms: Role of GI-Mechanical Destructive Forces and Colonic Release in Drug Absorption Under Fasted and Fed Conditions in Humans | Mohammed Shameem, Noriko Katori, Nobuo Aoyagi and Shigeo Kojima |
| 1055-1059 | Physicochemical, Pharmacokinetic and Pharmacodynamic Evaluation of Liposomal Tacrolimus (FK 506) in Rats | Mi-Jeong Lee, Robert M. Straubinger and William J. Jusko |
| 1060-1064 | Long-Circulating Emulsions (Oil-in-Water) as Carriers for Lipophilic Drugs | Feng Liu and Dexi Liu |
| 1065-1071 | Pharmacokinetics of lopromide Liposomes in Rabbits | Gabriele Schuhmann-Giampieri, Jens Leike, Andreas Sachse and Werner Krause |
| 1072-1076 | Adsorption of Salmon Calcitonin to PLGA Microspheres | Sema Calis, Ramasubbu Jeyanthi, Tsuimin Tsai, Rahul C. Mehta and Patrick P. DeLuca |
| 1077-1084 | Effects of Insulin Concentration and Self-Association on the Partitioning of Its A-21 Cyclic Anhydride Intermediate to Desamido Insulin and Covalent Dimer | Richard T. Darrington and Bradley D. Anderson |
| 1085-1091 | Effect of Aging on the Kinetics of Blood–Brain Barrier Uptake of Tryptophan in Rats | Jian-Ping Tang and Srikumaran Melethil |
| 1092-1095 | Uptake of Fractionated 3H-Heparin by Isolated Rat Kupffer Cells | Jim Watanabe, Masami Haba and Hiroaki Yuasa |
| 1096-1100 | Pharmacokinetic/Pharmacodynamic Evaluation of Deflazacort in Comparison to Methylprednisolone and Prednisolone | Helmut Möllmann, Günther Hochhaus, Shashank Rohatagi, Jürgen Barth and Hartmut Derendorf |
| 1101-1104 | pGlu-L-Dopa-Pro: A Tripeptide Prodrug Targeting the Intestinal Peptide Transporter for Absorption and Tissue Enzymes for Conversion | Jane P. F. Bai |
| 1105-1108 | Differential Induction of UDP-Glucuronosyltransferase Activity and Gene Expression in Rat Liver | Bradley K. Wong, Peiwen Fei and A.-N. Tony Kong |
| 1109-1114 | Hepatic Membrane Transport of Organic Cations Using Isolated Rat Hepatocyte Membrane Vesicles: Structure–Transport Relationships | Younggil Kwon and Marilyn E. Morris |
| 1115-1119 | Permeability of Peptides and Proteins in Human Cultured Alveolar A549 Cell Monolayer | Shinzo Kobayashi, Shuji Kondo and Kazuhiko Juni |
| 1120-1125 | Mechanisms of Transport of Quinapril in Caco-2 Cell Monolayers: Comparison with Cephalexin | Ming Hu, Lixing Zheng, Jiyue Chen, Lijuan Liu and Yanping Zhu, et al. |
| 1126-1133 | Enhanced Oral Bioavailability of DDI After Administration of 6-Cl-ddP, an Adenosine Deaminase-Activated Prodrug, to Chronically Catheterized Rats | Bradley D. Anderson, Michael E. Morgan and Dharmendra Singhal |
| 1134-1139 | Echo-Planar Magnetic Resonance Imaging to Assess Water Volume in the Distal Small Bowel | Dawn A. Adkin, Penny Gowland, Robin C. Spiller, Alan Freeman and Jonathon Hykin, et al. |
| 1140-1145 | Transport of Biologically Active Interferon-gamma Across Human Skin in Vitro | Sarah M. Short, Werner Rubas, Brian D. Paasch and Randall J. Mrsny |
| 1146-1150 | Different Effects of Absorption Promoters on Corneal and Conjunctival Penetration of Ophthalmic Beta-Blockers | Hitoshi Sasaki, Yoshiaki Igarashi, Toshiaki Nagano, Koyo Nishida and Junzo Nakamura |
| 1151-1157 | Effects of Absorption Enhancers on Rat Nasal Epithelium in Vivo: Release of Marker Compounds in the Nasal Cavity | Emmeline Marttin, J. Coos Verhoef, Stefan G. Romeijn and Frans W. H. M. Merkus |
| 1158-1164 | Species Dependent Esterase Activities for Hydrolysis of an Anti-HIV Prodrug Glycovir and Bioavailability of Active SC-48334 | Chyung S. Cook, Peter J. Karabatsos, Grant L. Schoenhard and Aziz Karim |
| 1165-1170 | Metabolism of Dynorphin A 1-13 in Human Blood and Plasma | Stefan Müller and Günther Hochhaus |
| 1171-1175 | Transepithelial Transport of Insulin: I. Insulin Degradation by Insulin-Degrading Enzyme in Small Intestinal Epithelium | Jane P. F. Bai and L. L. Chang |
| 1176-1183 | Preparation and Characterization of Dextran Magnetite-Incorporated Thermosensitive Liposomes: An on-line Flow System for Quantifying Magnetic Responsiveness | Ekapop Viroonchatapan, Masaharu Ueno, Hitoshi Sato, Isao Adachi and Hideo Nagae, et al. |
| 1184-1188 | Influence of Nonionic Liposomal Composition on Topical Delivery of Peptide Drugs into Pilosebaceous Units: An in Vivo Study Using the Hamster Ear Model | Susan M. Niemiec, Chandrasekharan Ramachandran and Norman Weiner |
| 1189-1198 | Liposomal Formulations of Cyclosporin A: Influence of Lipid Type and Dose on Pharmacokinetics | A. Fahr, M. Holz and G. Fricker |
| 1199-1204 | Quantitative Structure Activity Relationships of Catechol Derivatives on Nerve Growth Factor Secretion in L-M Cells | Angeliki Kourounakis and Nicholas Bodor |
| 1205-1210 | The Effect of Electrostatic Charge Interactions on Release Rates of Gentamicin from Collagen Matrices | Manish P. Singh, Joseph Stefko, Janice A. Lumpkin and Joel Rosenblatt |
| 1211-1217 | Polymeric Microspheres Prepared by Spraying into Compressed Carbon Dioxide | Roland Bodmeier, Hui Wang, David J. Dixon, Simon Mawson and Keith P. Johnston |
| 1218-1224 | Measurements of Size Distribution and Density of a Pharmaceutical Fat Emulsion, Using Field-Programmed Sedimentation Field-Flow Fractionation (SdFFF) | Shulamit Levin and Eytan Klausner |
| 1225-1230 | MicroPharm-K, a Microcomputer Interactive Program for the Analysis and Simulation of Pharmacokinetic Processes | Saïk Urien |
| 1231-1237 | Solubilisation of Drugs in Micellar Systems Studied by Eluent Gel Permeation Chromatography | Michael Draper, Matthew Savage, John H. Collett, David Attwood and Colin Price, et al. |
| 1238-1239 | Unbound Total (Plasma) Clearance Approach in Interspecies Pharmacokinetics Correlation: Theophylline-Cimetidine Interaction | Win L. Chiou and Young M. Choi |
| 1240-1243 | Synthesis and Pharmacological Evaluation of Spiro-Analogues of 5-Benzyl-5-ethyl Barbituric Acid | S. Bruce King, Eugene S. Stratford, Charles R. Craig and E. Kim Fifer |
| 1244 | ERRATUM |
| 1245-1246 | EDITORIAL |
| 1247 | The Many Faces of Pharmaceutical Research | Bernard Testa |
| 1248-1249 | Methodologies for Pharmaceutical Effectiveness and Pharmacoeconomics Research | Carol B. Gable |
| 1250-1259 | Optimization of Lyophilization Conditions for Recombinant Human Interleukin-2 by Dried-State Conformational Analysis Using Fourier-Transform Infrared Spectroscopy | Steven J. Prestrelski, Katherine A. Pikal and Tsutomu Arakawa |
| 1260-1263 | Vial Lyophilization: Calculations on Rate Limitation During Primary Drying | Hester Ybema, Lia Kolkman-Roodbeen, Marcel P. W. M. te Booy and Herman Vromans |
| 1264-1268 | Computer Simulation of Tablet Motion in Coating Drum | Kenji Yamane, Toshiharu Sato, Toshitsugu Tanaka and Yutaka Tsuji |
| 1269-1272 | Preparation of Controlled-Release Coevaporates of Dipyridamole by Loading Neutral Pellets in a Fluidized-Bed Coating System | Deniz B. Beten, Karim Amighi and André J. Moës |
| 1273-1278 | Physicochemical Characterization of Parenteral Lipid Emulsion: Influence of Cosurfactants on Flocculation and Coalescence | Tetsuo Yamaguchi, Kaori Nishizaki, Shigeru Itai, Hidefumi Hayashi and Hiroyuki Ohshima |
| 1279-1283 | Hydrophobic Contribution Constants of Amino Acid Residues to the Hydrophobicities of Oligopeptides | Hua Gao, Fengzhen Wang and Eric J. Lien |
| 1284-1288 | Precipitation of Insulinotropin in the Presence of Protamine: Effect of Phenol and Zinc on the Isophane Ratio and the Insulinotropin Concentration in the Supernatant | Yesook Kim and Carol A. Rose |
| 1289-1292 | Cholate-Induced Disruption of Calcitonin-Loaded Liposomes: Formation of Trypsin-Resistant Lipid-Calcitonin-Cholate Complexes | Albertina Ariën, Nelly Toulmé-Henry and Bernard Dupuy |
| 1293-1298 | Mucoadhesive Polymers in Peroral Peptide Drug Delivery. II. Carbomer and Polycarbophil Are Potent Inhibitors of the Intestinal Proteolytic Enzyme Trypsin | Henrik L. Lueßen, J. Coos Verhoef, Gerrit Borchard, Claus-M. Lehr and A. (Bert) G. de Boer, et al. |
| 1299-1303 | The Intestinal Transport Mechanism of Fluoroquinolones: Inhibitory Effect of Ciprofloxacin, an Enoxacin Derivative, on the Membrane Potential-Dependent Uptake of Enoxacin | Takeshi Hirano, Ken Iseki, Izumi Sato, Shozo Miyazaki and Masahiko Takada, et al. |
| 1304-1310 | Possible Involvement of Multiple P-Glycoprotein-Mediated Efflux Systems in the Transport of Verapamil and Other Organic Cations Across Rat Intestine | Hiroshi Saitoh and Bruce J. Aungst |
| 1311-1315 | Regional Gastrointestinal Absorption of Ranitidine in the Rat | Benjamin Suttle and Kim L. R. Brouwer |
| 1316-1322 | Gastrointestinal Transit and Distribution of Ranitidine in the Rat | A. Benjamin Suttle and Kim L. R. Brouwer |
| 1323-1327 | First-Pass Accumulation of Salicylic Acid in Gut Tissue After Absorption in Anesthetized Rat | Young M. Choi, Sang M. Chung and Win L. Chiou |
| 1328-1332 | Drug Delivery Studies in Caco-2 Monolayers. IV. Absorption Enhancer Effects of Cyclodextrins | Lars Hovgaard and Helle Brøndsted |
| 1333-1337 | New Evaluation Method for in Vitro/in Vivo Correlation of Enteric-Coated Multiple Unit Dosage Forms | Takashi Hayashi, Toshihiro Ogura and Yasushi Takagishi |
| 1338-1342 | Development and in Vitro-in Vivo Evaluation of a Multiparticulate Sustained Release Formulation of Diltiazem | Shun Por Li, Robert G. Felt, Louis C. Di Paolo, Mei-Ying Huang and Robert O. Williams III |
| 1343-1349 | The Pulmonary Absorption of Aerosolized and Intratracheally Instilled rhG-CSF and monoPEGylated rhG-CSF | Ralph W. Niven, K. Lane Whitcomb, Linda Shaner, Anna Y. Ip and Olaf B. Kinstler |
| 1350-1353 | Pharmacokinetics of 1 -(2-Deoxy-2-fluoro-β-L-arabino-furanosyl)-5-methyluracil (L-FMAU) in Rats | Jennifer D. Wright, Tianwei Ma, Chung K. Chu and F. Douglas Boudinot |
| 1354-1360 | Absorption of Sunscreens and Other Compounds Through Human Skin inVivo: Derivation of a Method to Predict Maximum Fluxes | Ursula Hagedorn-Leweke and Bernhard C. Lippold |
| 1361-1370 | Hydrolysis of the Prodrug, 2′, 3′, 5′ -Triacetyl-6-azauridine | C. M. Riley, M. A. Mummert, J. Zhou, R. L. Schowen and D. G. Vander Velde, et al. |
| 1371-1375 | Hydroxypropyl-β-Cyclodextrin Increases the Aqueous Solubility and Stability of Pilocarpine Prodrugs | Pekka Jarho, Arto Urtti and Tomi Järvinen |
| 1376-1379 | Measurement of the Diffusion of 2,2,2-trifluoroacetamide Within Thermoresponsive Hydrogels Using NMR Imaging | R. Dinarvand, B. Wood and A. D'Emanuele |
| 1380-1384 | Particle Size Distribution of Single and Multiple Sprays of Salbutamol Metered-Dose Inhalers (MDIs) | Susan J. Graham, Robert C. Lawrence, Eric D. Ormsby and Richard K. Pike |
| 1385-1387 | Influence of Surface Properties on the Inflammatory Response to Polymeric Nanoparticles | Rocío Fernández-Urrusuno, Elias Fattal, Dominique Porquet, Jeanne Féger and Patrick Couvreur |
| 1388-1390 | Evidence for the Lack of a Human Metabolic Isotope Effect of a Deuterium Analog of Fluphenazine | Salim Hadad, John W. Hubbard, Gordon McKay, Edward M. Hawes and Satishche Shrikhande, et al. |
| 1391-1392 | EDITORIAL |
| 1393-1394 | Quo Vadis, Pharmaceutical Sciences, and AAPS? | Wolfgang Sadée |
| 1395-1406 | Cerebrovascular Permeability to Peptides: Manipulations of Transport Systems at the Blood-Brain Barrier | Berislav V. Zlokovic |
| 1407-1416 | Thermosensitive Sterically Stabilized Liposomes: Formulation and in Vitro Studies on Mechanism of Doxorubicin Release by Bovine Serum and Human Plasma | Mohamed H. Gaber, Keelung Hong, Shi Kun Huang and Demetrios Papahadjopoulos |
| 1417-1422 | Application of a Membrane Fusion Assay for Rapid Drug Screening | Steven S. Vogel, Sven Beushausen and David S. Lester |
| 1423-1429 | An Improved Method for Determination of Acid Dissociation Constants of Peptides | Xiaojun Fang, Quintus Fernando, Sydney O. Ugwu and James Blanchard |
| 1430-1434 | Conformational Analysis of Methylphenidate and Its Structural Relationship to Other Dopamine Reuptake Blockers Such as CFT | Mark Froimowitz, Kennerly S. Patrick and Vivian Cody |
| 1435-1438 | Determination of the Surface Tension of Block Copolymer Micelles by Phagocytosis | Alain Rolland, Frank Paul, Katherine M. Stott and Cedric J. Olliff |
| 1439-1446 | Characterization of the MN gp120 HIV-1 Vaccine: Antigen Binding to Alum | Robert P. Weissburg, Phillip W. Berman, Jeffrey L. Cleland, Donna Eastman and Francis Farina, et al. |
| 1447-1452 | A New Strategy for Enhancing the Stability of Lyophilized Protein: The Effect of the Reconstitution Medium on Keratinocyte Growth Factor | Mei Z. Zhang, Jie Wen, Tsutomu Arakawa and Steven J. Prestrelski |
| 1453-1456 | Thermodynamic Study of Sulfanilamide Polymorphism: (I) Monotropy of the α-Variety | Siro Toscani, Sven Thorén, Viatcheslav Agafonov, René Céolin and Jérôme Dugué |
| 1457-1461 | Glycine Crystallization During Freezing: The Effects of Salt Form, pH, and Ionic Strength | Michael J. Akers, Nathaniel Milton, Stephen R. Byrn and Steven L. Nail |
| 1462-1465 | The Effect of Food on Pharmacokinetics of Zalcitabine in HIV-Positive Patients | L. A. Nazareno, A. A. Holazo, R. Limjuco, S. Passe and S. K. Twardy, et al. |
| 1466-1469 | Renal Clearance of a Recombinant Granulocyte Colony-Stimulating Factor, Nartograstim, in Rats | Takashi Kuwabara, You Ishikawa, Hiroyuki Kobayashi, Satoshi Kobayashi and Yuichi Sugiyama |
| 1470-1473 | Snake F(ab′)2 Antivenom from Hyperimmunized Horse: Pharmacokinetics Following Intravenous and Intramuscular Administrations in Rabbits | Stephanie Pepin, Charles Lutsch, Michel Grandgeorge and Jean-Michel Scherrmann |
| 1474-1477 | Pharmacokinetic Studies of Methotrexate in Plasma and Synovial Fluid Following IV Bolus and Topical Routes of Administration in Dogs | G. W. Lu, H. W. Jun, M. T. Dzimianski, H. C. Qiu and J. W. McCall |
| 1478-1482 | Enhanced Intestinal Absorption of Oxytocin Peptide Analogues in the Absence of Pancreatic Juice in Pigs | Pål D. P. Lundin, Stefan Lundin, Håkan Olsson, Börje W. Karlsson and Björn R. Weström, et al. |
| 1483-1487 | Transport Characteristics of Ceftibuten, a New Cephalosporin Antibiotic, via the Apical H+/Dipeptide Cotransport System in Human Intestinal Cell Line Caco-2: Regulation by Cell Growth | Shin-ichi Matsumoto, Hideyuki Saito and Ken-ichi Inui |
| 1488-1492 | Transport Characteristics of S-1090, A New Oral Cephem, in Rat Intestinal Brush-Border Membrane Vesicles | Noriyuki Muranushi, Naofumi Hashimoto and Koichiro Hirano |
| 1493-1498 | Microbial and Mammalian Metabolism Studies on the Semisynthetic Antimalarial, Deoxoartemisinin | Sherief I. Khalifa, John K. Baker, Mankil Jung, James D. McChesney and Charles D. Hufford |
| 1499-1505 | Development and Characterization of Rabbit Tracheal Epithelial Cell Monolayer Models for Drug Transport Studies | Neil R. Mathias, Kwang-Jin Kim, Timothy W. Robison and Vincent H. L. Lee |
| 1506-1512 | Role of Appendages in Skin Resistance and lontophoretic Peptide Flux: Human Versus Snake Skin | W. (Ine) H. M. Craane-van Hinsberg, J. Coos Verhoef, Leo. J. Bax, Hans E. Junginger and Harry E. Boddé |
| 1513-1520 | Controlled Release of Substituted Benzole and Naphthoic Acids Using Carbopol ® Gels: Measurement of Drug Concentration Profiles and Correlation to Release Rate Kinetics | Donna L. French, Bert O. Häglund, Kenneth J. Himmelstein and John W. Mauger |
| 1521-1525 | A Cellular Automata Model of Dissolution | Lemont B. Kier and Chao-Kun Cheng |
| 1526-1529 | A Solubility and Related Physicochemical Property Comparison of Buprenorphine and Its 3-Alkyl Esters | Audra L. Stinchcomb, Rajesh Dua, Anupam Paliwal, Ronald W. Woodard and Gordon L. Flynn |
| 1530-1534 | Age-Related Changes in Pharmacokinetic Parameters of Phenytoin After Liver Resection in Rats | Emi Nakashima, Ryo Matsushita, Yasunori Iida, Tohru Ohshima and Fujio Ichimura |
| 1535-1538 | Influence of Lipophilicity on the Protein Binding Affinity of Cephalosporins | Fabienne Demotes-Mainard Péhourcq, Ahmed Radouane, Laurence Labat and Bernard Bannwarth |
| 1539-1544 | Identification of Enzymatic Degradation Products of Luteinizing Hormone Releasing Hormone (LHRH)/[D-Ala6] LHRH in Rabbit Mucosal Homogenates | Kun Han, Jeong Sook Park, Youn Bok Chung, Mi Jeong Lee and Dong Cheul Moon, et al. |
| 1545-1547 | Poly(D,L-Lactide) Nanocapsules Containing Non-Steroidal Anti-Inflammatory Drugs: Gastrointestinal Tolerance Following Intravenous and Oral Administration | Silvia Stanisçuaski Guterres, Hatem Fessi, Gillian Barratt, Francis Puisieux and Jean-Philippe Devissaguet |
| 1548-1553 | Improved Cellular Delivery of Antisense Oligonucleotides Using Transferrin Receptor Antibody-Oligonucleotide Conjugates | Ian Walker, William J. Irwin and Saghir Akhtar |
| 1554-1555 | BOOK REVIEWS |
| 1557-1559 | EDITORIAL |
| 1560 | WHAT IS THE CURRENT NIGMS SCORING EXPERIMENT? HOW DOES IT WORK? WHAT IS IT ATTEMPTING TO ACCOMPLISH? | Rochelle M. Long |
| 1561-1572 | Lipid Microemulsions for Improving Drug Dissolution and Oral Absorption: Physical and Biopharmaceutical Aspects | Panayiotis P. Constantinides |
| 1573-1582 | Does Fluid Flow Across the Intestinal Mucosa Affect Quantitative Oral Drug Absorption? Is It Time for a Reevaluation? | Hans Lennernäs |
| 1583-1591 | Stabilization of the Hydrophilic Sphere of lobitridol, an lodinated Contrast Agent, as Revealed by Experimental and Computational Investigations | Dominique Meyer, Marie-Hélène Fouchet, Myriam Petta, Pierre-Alain Carrupt and Patrick Gaillard, et al. |
| 1592-1597 | Pharmacokinetics and Anticonvulsant Effect of a New Hypnotic, CL 284,846, in Rats | Jacques Gaudreault, France Varin and Gary M. Pollack |
| 1598-1604 | Human MCAF Gene Transfer Enhances the Metastatic Capacity of a Mouse Cachectic Adenocarcinoma Cell Line in Vivo | Emi Nakashima, Naofumi Mukaida, Yuri Kubota, Kouji Kuno and Kazuo Yasumoto, et al. |
| 1605-1613 | The Electrical Characteristics of Human Skin in Vivo | Yogeshvar N. Kalia and Richard H. Guy |
| 1614-1617 | Apparent pKa of the Fatty Acids Within Ordered Mixtures of Model Human Stratum Corneum Lipids | Renate Lieckfeldt, José Villalaín, Juan-Carlos Gómez-Fernández and Geoffrey Lee |
| 1618-1622 | Effect of PGML Excipient Mixture in a Transdermal System on the in Vitro Transport of Estradiol Across Skin | Gretchen D. Irion, Michael D. Garrison and William Abraham |
| 1623-1627 | Iontophoresis Enhances the Transport of Acyclovir Through Nude Mouse Skin by Electrorepulsion and Electroosmosis | Nadia Maria Volpato, Patrizia Santi and Paolo Colombo |
| 1628-1633 | A Predictive Algorithm for Skin Permeability: The Effects of Molecular Size and Hydrogen Bond Activity | Russell O. Potts and Richard H. Guy |
| 1634-1641 | Evaluation of Bioequivalence of Highly Variable Drugs Using Monte Carlo Simulations. I. Estimation of Rate of Absorption for Single and Multiple Dose Trials Using Cmax | Ahmed A. El-Tahtawy, André J. Jackson and Thomas M. Ludden |
| 1642-1646 | Effect of Omeprazole on Diazepam Disposition in the Rat: in Vitro and in Vivo Studies | K. Zomorodi and J. B. Houston |
| 1647-1651 | Effects of Gender, Pregnancy, and Anesthesia on the Pharmacokinetics of Zidovudine in Rats | Christine S.-H. Huang, F. Douglas Boudinot and Stuart Feldman |
| 1652-1657 | The Problem of Racemization in the Stereospecific Assay and Pharmacokinetic Evaluation of Ketorolac in Human and Rats | Majid Vakily, Brian Corrigan and Fakhreddin Jamali |
| 1658-1663 | Inhibition of Pulmonary Surfactant Biophysical Activity by Cationic Polyamino Acids | Paul M. Bummer, Shewan Aziz and Mark N. Gillespie |
| 1664-1670 | The Application of Crystal Soaking Technique to Study the Effect of Zinc and Cresol on Insulinotropin Crystals Grown from a Saline Solution | Yesook Kim and Anne M. Haren |
| 1671-1676 | Estimation of Recombinant Bovine Somatotropin Solubility by Excluded-Volume Interaction with Polyethylene Glycols | Cynthia L. Stevenson and Michael J. Hageman |
| 1677-1681 | Loading Effect on Particle Size Measurements by Inertial Sampling of Albuterol Metered Dose Inhalers | Moheb M. Nasr and James F. Allgire |
| 1682-1688 | Nebulization of Fluids of Different Physicochemical Properties with Air-Jet and Ultrasonic Nebulizers | Orla N. M. McCallion, Kevin M. G. Taylor, Marian Thomas and Anthony J. Taylor |
| 1689-1693 | A Microcalorimetric Investigation of the Interaction of Surfactants with Crystalline and Partially Crystalline Salbutamol Sulphate in a Model Inhalation Aerosol System | Peter M. Blackett and Graham Buckton |
| 1694-1700 | Structure of Disintegrating Pellets with Regard to Fractal Geometry | Martin Schröder and Peter Kleinebudde |
| 1701-1707 | Thermophysical Properties of Some Pharmaceutical Excipients Compressed in Tablets | Jarkko Ketolainen, L'udovit Kubičár, Vlastimil Boháč, Marián Markovič and Petteri Paronen |
| 1708-1715 | Photoinstability of Some Tyrphostin Drugs: Chemical Consequences of Crystallinity | Narendra Kumar, Vincent Windisch and Herman L. Ammon |
| 1716-1721 | Absorption and Presystemic Metabolism of Nefazodone Administered at Different Regions in the Gastrointestinal Tract of Humans | Punit H. Marathe, Daniel E. Salazar, Douglas S. Greene, John Brennan and Umesh A. Shukla, et al. |
| 1722-1726 | The Site of Absorption in the Small Intestine Determines Diltiazem Bioavailability in the Rabbit | Walid Homsy, Gilles Caillé and Patrick du Souich |
| 1727-1732 | Proton-Cotransport of Pravastatin Across Intestinal Brush-Border Membrane | Ikumi Tamai, Hitomi Takanaga, Hiroshi Maeda, Takuo Ogihara and Masaru Yoneda, et al. |
| 1733-1736 | Sucrose Urinary Excretion in the Rat Measured Using a Simple Assay: A Model of Gastroduodenal Permeability | Neal M. Davies, Brian W. Corrigan and Fakhreddin Jamali |
| 1737-1740 | Contribution of Parenchymal and Non-Parenchymal Liver Cells to the Clearance of Hepatocyte Growth Factor From the Circulation in Rats | Ke-Xin Liu, Yukio Kato, Tetsuya Terasaki, Shoichi Aoki and Kazuo Okumura, et al. |
| 1741-1745 | Evaluation of the Uptake of Pravastatin by Perfused Rat Liver and Primary Cultured Rat Hepatocytes | Michi Ishigami, Taro Tokui, Toru Komai, Kosyo Tsukahara and Masayo Yamazaki, et al. |
| 1746-1755 | Kinetic Analysis of Hepatobiliary Transport for Conjugated Metabolites in the Perfused Liver of Mutant Rats (EHBR) with Hereditary Conjugated Hyperbilirubinemia | Osamu Takenaka, Toru Horie, Kazuo Kobayashi, Hiroshi Suzuki and Yuichi Sugiyama |
| 1756-1760 | Hepatoprotective Activity of Xanthones and Xanthonolignoids Against tert-Butylhydroperoxide-Induced Toxicity in Isolated Rat Hepatocytes—Comparison with Silybin | Eduarda R. Fernandas, Félix D. Carvalho, Fernando G. Remião, Maria Lourdes Bastos and Madalena M. Pinto, et al. |
| 1761-1768 | Gamma-Irradiation of Non-Frozen, Frozen, and Freeze-Dried Liposomes | Nicolaas J. Zuidam, Stephen S. L. Lee and Daan J. A. Crommelin |
| 1769-1774 | Enhanced Therapeutic Effect of Cytidine-5′ -Diphosphate Choline when Associated with GM1 Containing Small Liposomes as Demonstrated in a Rat Ischemia Model | Massimo Fresta, Ernst Wehrli and Giovanni Puglisi |
| 1775-1780 | Antibody Dependent, Complement Mediated Liver Uptake of Liposomes Containing GM1 | Dexi Liu, Young K. Song and Feng Liu |
| 1781-1785 | Drug Release From Hydrocolloid Embeddings with High or Low Susceptibility to Hydrodynamic Stress | Wolfram D. Lindner and Bernhard C. Lippold |
| 1786-1790 | The Release of 5-Fluorouracil from a Swellable Matrix of a Triblock Copolymer of ε-Caprolactone and Ethylene Oxide | Luigi G. A. Martini, John H. Collett and David Attwood |
| 1791-1795 | Ocular Availability of Gentamicin in Small Animals After Topical Administration of a Conventional Eye Drop Solution and a Novel Long Acting Bioadhesive Ophthalmic Drug Insert | Florian Gurtler, Vassilios Kaltsatos, Bernard Boisramé, Jean Deleforge and Marianne Gex-Fabry, et al. |
| 1796-1800 | Biodegradable Delivery System for a Birth Control Vaccine: Immunogenicity Studies in Rats and Monkeys | Manmohan Singh, Om Singh and G. P. Talwar |
| 1801-1805 | Transport of Peptidomimetic Renin Inhibitors Across Monolayers of a Human Intestinal Cell Line (Caco-2): Evidence for Self-Enhancement of Paracellular Transport Route | Elke Walter, Thomas Kissel and Peter Raddatz |
| 1806-1809 | Reconversion of Fosphenytoin in the Presence of Intestinal Alkaline Phosphatase | Christopher N. TenHoor and Barbra H. Stewart |
| 1810-1812 | A Novel Isolation Method of a Stable Crystalline Salt of a Cyclic RGD Peptide Zwitterion | Michael B. Maurin and Munir A. Hussain |
| 1813-1816 | Ionic Strength Dependence of Dissolution for Eudragit S-100 Coated Pellets | Tugrul T. Kararli, Carol F. Kirchhoff and James E. Truelove |
| 1817-1819 | EDITORIAL |
| 1820 | WHAT INFORMATION ABOUT THE NIGMS IS PRESENTLY AVAILABLE ON THE WORLD WIDE WEB? WHAT IS COMING NEXT? | Rochelle M. Long |
| 1821-1822 | Imaging Can Be Much More Than Pretty Pictures | Walter Wolf |
| 1823-1837 | Biology of Membrane Transport Proteins | Wolfgang Sadée, Volkmar Drübbisch and Gordon L. Amidon |
| 1838-1844 | Study on Brain Interstitial Fluid Distribution and Blood-Brain Barrier Transport of Baclofen in Rats by Microdialysis | Yoshiharu Deguchi, Kazimori Inabe, Koichi Tomiyasu, Kenji Nozawa and Shizuo Yamada, et al. |
| 1845-1855 | Population Pharmacokinetic Modeling: The Importance of Informative Graphics | Ene I. Ette and Thomas M. Ludden |
| 1856-1864 | Sensitive and Specific Determination of the Equivalence of Absorption Rates | Laszlo Endrenyi and Passant Al-Shaikh |
| 1865-1868 | An Approach for Widening the Bioequivalence Acceptance Limits in the Case of Highly Variable Drugs | Alexander W. Boddy, Fred C. Snikeris, Robert O. Kringle, Greg C. G. Wei and James A. Oppermann, et al. |
| 1869-1873 | Reverse Iontophoresis: Noninvasive Glucose Monitoring in Vivo in Humans | G. Rao, R. H. Guy, P. Glikfeld, W. R. LaCourse and L. Leung, et al. |
| 1874-1877 | Dose-Dependent Pharmacokinetics of Warfarin in Healthy Volunteers | Shang-Ying P. King, Mark A. Joslin, Karen Raudibaugh, Henry J. Pieniaszek and Irma H. Benedek |
| 1878-1882 | Intra- and Inter-Subject Variabilities of CGP 33101 after Replicate Single Oral Doses of Two 200-mg Tablets and 400-mg Suspension | Wing K. Cheung, Farid Kianifard, Audrey Wong, Josette Mathieu and Terry Cook, et al. |
| 1883-1888 | Prolonged Circulation of Recombinant Human Granulocyte–Colony Stimulating Factor by Covalent Linkage to Albumin Through a Heterobifunctional Polyethylene Glycol | Aimee Guider Paige, K. Lane Whitcomb, Jennifer Liu and Olaf Kinstler |
| 1889-1895 | Systemic Absorption and Activity of Recombinant Consensus Interferons After Intratracheal Instillation and Aerosol Administration | Ralph W. Niven, K. Lane Whitcomb, Melissa Woodward, Jennifer Liu and Concesa Jornacion |
| 1896-1900 | The Effect of Cetylpyridinium Chloride (CPC) on the Cell Surface Hydrophobicity and Adherence of Candida albicansto Human Buccal Epithelial Cells in Vitro | David S. Jones, Leo J. Schep and Max G. Shepherd |
| 1901-1906 | Extensive Absorption of 2′,3′-Dideoxyinosine by Intratracheal Administration in Rats | Xiang Gao, M. Guillaume Wientjes and Jessie L.-S. Au |
| 1907-1916 | Diffusion of an Anti-Transferrin Receptor Antibody in Cultured Murine Melanoma Cell Layers | Venkatramani Vijaykumar and Elizabeth M. Topp |
| 1917-1923 | A Semisynthetic Quillaja Saponin as a Drug Delivery Agent for Aminoglycoside Antibiotics | Joanne Recchia, Maria H. A. Lurantos, Jennifer A. Amsden, James Storey and Charlotte R. Kensil |
| 1924-1931 | The Use of Intracerebral Microdialysis for the Determination of Pharmacokinetic Profiles of Anticancer Drugs in Tumor-Bearing Rat Brain | E. C. M. de Lange, J. D. de Vries, C. Zurcher, M. Danhof and A. G. de Boer, et al. |
| 1932-1936 | Transport of a Hydrophilic Compound into the Cerebrospinal Fluid During Experimental Allergic Encephalomyelitis and After Lipopolysaccharide Administration | Helga E. de Vries, Elaine F. Eppens, Martine Prins, Johan Kuiper and Theo J. C. van Berkel, et al. |
| 1937-1942 | A Novel Oligodeoxynucleotide Inhibitor of Thrombin. I. In VitroMetabolic Stability in Plasma and Serum | Jeng-Pyng Shaw, James A. Fishback, Kenneth C. Cundy and William A. Lee |
| 1943-1947 | A Novel Oligodeoxynucleotide Inhibitor of Thrombin. II. Pharmacokinetics in the Cynomolgus Monkey | William A. Lee, James A. Fishback, Jeng-Pyng Shaw, Louis C. Bock and Linda C. Griffin, et al. |
| 1948-1952 | Acceleration of Nitric Oxide (NO) Release from FK409, a Spontaneous NO Releaser, in the Presence of Sulfhydryl-bearing Compounds | Shinichi Fukuyama, Yoshimi Hirasawa, Dermot Cox, Shigetaka Koda and Yasuhiro Kita |
| 1953-1957 | Effect of Acute Renal Failure on Neurotoxicity of Cimetidine in Rats | Yu Nakada, Koujirou Yamamoto, Junichi Kawakami, Yasufumi Sawada and Tatsuji Iga |
| 1958-1963 | Renal Disposition and Drug Interaction Screening of (–)-2′-deoxy-3′-thiacytidine (3TC) in the Isolated Perfused Rat Kidney | Kevin R. Sweeney, Poe-Hirr Hsyu, Paul Statkevich and David R. Taft |
| 1964-1967 | Effect of Probenecid on the Enantioselective Pharmacokinetics of Oxprenolol and Its Glucuronides in the Rabbit | Martine E. Laethem, Frans M. Belpaire, Pascal Wijnant and Marc G. Bogaert |
| 1968-1972 | Characterization of LLC-PK1 Kidney Epithelial Cells as an in Vitro Model for Studying Renal Tubular Reabsorption of Protein Drugs | Yoshinobu Takakura, Takahiro Morita, Makoto Fujikawa, Mitsuko Hayashi and Hitoshi Sezaki, et al. |
| 1973-1979 | Vitamin K Prodrugs: 2. Water-Soluble Prodrugs of Menahydroquinone-4 for Systemic Site-Specific Delivery | Jiro Takata, Yoshiharu Karube, Mitsunobu Hanada, Kazuhisa Matsunaga and Yoshikazu Matsushima, et al. |
| 1980-1986 | Regional Drug Delivery I: Permeability Characteristics of the Rat 6-Day-Old Air Pouch Model of Inflammation | Steven W. Martin, Alexander J. Stevens, Beverley S. Brennan, Marina L. Reis and Lawrence A. Gifford, et al. |
| 1987-1996 | Regional Drug Delivery II: Relationship Between Drug Targeting Index and Pharmacokinetic Parameters for Three Non-Steroidal Anti-Inflammatory Drugs Using the Rat Air Pouch Model of Inflammation | Alexander J. Stevens, Steven W. Martin, Beverley S. Brennan, Andrew McLachlan and Lawrence A. Gifford, et al. |
| 1997-2002 | Controlled Release of Lidocaine from Injectable Gels and Efficacy in Rat Sciatic Nerve Block | Anne Paavola, Jouko Yliruusi, Yoji Kajimoto, Eija Kalso and Torsten Wahlström, et al. |
| 2003-2011 | Accurate Determination of Skin Flux from Flow-Through Diffusion Cell Data | Daniel J. Harrison and Kristine Knutson |
| 2012-2017 | Use of Drug Kinetics in Dermis to Predict in VivoBlood Concentration After Topical Application | Xiang Gao, M. Guillaume Wientjes and Jessie L.-S. Au |
| 2018-2023 | Radial Spread of Sodium Lauryl Sulfate After Topical Application | Sunita Patil, Parminder Singh and Howard Maibach |
| 2024-2029 | Absorption of an Oxytocin Antagonist (Antocin) and a Vasopressin Analogue (dDAVP) Through a Standardized Skin Erosion in Volunteers | Stefan Lundin, Pål Svedman, Peter Höglund, Karin Jönsson and Anja Breeders, et al. |
| 2030-2035 | Analysis of Drug Distribution in Hydrogels Using Fourier Transform Infrared Microscopy | Mary Tanya am Ende and Nikolaos A. Peppas |
| 2036-2040 | A Graphical Method for the Determination of the Mode of Hydrolysis of Biodegradable Polymers | Chung Shih |
| 2041-2048 | Calculation of Hydrolytic Rate Constants of Poly(ortho ester)s from Molecular Weights Determined by Gel Permeation Chromatography | Chung Shih |
| 2049-2052 | Oxidation of Recombinant Human Parathyroid Hormone: Effect of Oxidized Position on the Biological Activity | Yoshiaki Nabuchi, Eri Fujiwara, Kenjyu Ueno, Hitoshi Kuboniwa and Yoshinori Asoh, et al. |
| 2053-2056 | Regioselectivity and Enantioselectivity of Metoprolol Oxidation by Two Variants of cDNA-Expressed P4502D6 | Douglas S. Mautz, Danny D. Shen and Wendel L. Nelson |
| 2057-2059 | The Effects of Sub-Inhibitory Concentrations of Cationic, Non-Antibiotic, Antimicrobial Agents on the Morphogenesis of Candida albicans in Vitro | David S. Jones |
| 2060-2064 | Biodegradable Indium-111 Labeled Microspheres for in Vivo Evaluation of Distribution and Elimination | Bagavathikanun C. Thanoo, Walter J. Doll, Rahul C. Mehta, George A. Digenis and Patrick P. DeLuca |
| 2065-2070 | The Effect of Absorption Enhancers on the Oral Absorption of the GP IIB/IIIA Receptor Antagonist, DMP 728, in Rats and Dogs | Deborah L. Burcham, Bruce A. Aungst, Munir Hussain, Mary Ann Gorko and Check Y. Quon, et al. |
| 2071-2074 | Use of Parent Drug and Metabolite Data in Bioavailability Assessment of a Novel Diltiazem HC1 Once-Daily Product | Okponanabofa Eradiri and Kamal K. Midha |
| 2075-2078 | AAPS Workshop on Designing the Global Chemistry, Manufacturing, and Controls (CMC) Dossier | Christine Carrico |
| 2079-2081 | Reviewers for Pharmaceutical Research January through October 1995 |
| 2082-2086 | Author Index to Volume 12 (1995) |
| 2087-2095 | Subject Index to Volume 12 (1995) |
| 1-5 | Editorial |
| 6-9 | AAPS/USP Workshop on Dissolution Calibration and Testing | Christine K. Carrico |
| 10-11 | How Much Compliance Is Enough? | John Urquhart |
| 12-17 | Intravenous Microdialysis in the Mouse and the Rat: Development and Pharmacokinetic Application of a New Probe | Pierre A. Evrard, G. Deridder and Roger K. Verbeeck |
| 18-22 | Concentration-Dependent Plasma Protein Binding of Flurbiprofen in the Rat: An in Vivo Microdialysis Study | Pierre A. Evrard, Jean Cumps and Roger K. Verbeeck |
| 23-26 | An Integrated Method to Determine Epithelial Transport and Bioactivity of Oral Drug Candidates in Vitro | Werner Rubas, Mary E. M. Cromwell, Randall J. Mrsny, Gladys Ingle and Kathleen A. Elias |
| 27-31 | Targeting of Drug to the Hepatocytes by Fatty Acids. Influence of the Carrier (Albumin or Galactosylated Albumin) on the Fate of the Fatty Acids and Their Analogs | Vinciane Charbon, Isabella Latour, Didier M. Lambert, Pedro Buc-Calderon and Laurence Neuvens, et al. |
| 32-37 | Albumin Nanospheres as Carriers for Passive Drug Targeting: An Optimized Manufacturing Technique | Bernhard G. Müller, Hans Leuenberger and Thomas Kissel |
| 38-43 | Pharmacokinetics and Biodistribution of Oligonucleotide Adsorbed onto Poly(isobutylcyanoacrylate) Nanoparticles After Intravenous Administration in Mice | Yuichiro Nakada, Elias Fattal, Monique Foulquier and Patrick Couvreur |
| 44-51 | Physicochemical Characterization of Protein-Free Low Density Lipoprotein Models and Influence of Drug Loading | Astrid Gerke, Kirsten Westesen and Michel H. J. Koch |
| 52-56 | The Influence of Buffer Species and Strength on Diltiazem HC1 Release from Beads Coated with the Aqueous Cationic Polymer Dispersions, Eudragit RS, RL 30D | Roland Bodmeier, Xiaodi Guo, Rafael E. Sarabia and Paul F. Skultety |
| 57-61 | Enhanced Cellular Uptake of Oligonucleotides by EGF Receptor-Mediated Endocytosis in A549 Cells | Deepa Deshpande, David Toledo-Velasquez, Deepak Thakkar, WeiWen Liang and Yon Rojanasakul |
| 62-69 | Derivatives of Dexanabinol. I. Water-Soluble Salts of Glycinate Esters | Emil Pop, Zong Zheng Liu, Marcus E. Brewster, Yechezkel Barenholz and Veronica Korablyov, et al. |
| 70-75 | Acyloxymethyl as a Drug Protecting Group. Part 3. Tertiary O-Amidomethyl Esters of Penicillin G: Chemical Hydrolysis and Anti-Bacterial Activity | Rui Moreira, Teresa Calheiros, José Cabrita, Eduarda Mendes and Madalena Pimentel, et al. |
| 76-79 | Effects of Phospholipid Chain Length, Concentration, Charge, and Vesicle Size on Pulmonary Insulin Absorption | Yuping Li and Ashim K. Mitra |
| 80-83 | Pulmonary Delivery of Salmon Calcitonin Dry Powders Containing Absorption Enhancers in Rats | Shinzo Kobayashi, Shuji Kondo and Kazuhiko Juni |
| 84-90 | A Pharmacokinetic Approach for Evaluating Cytokine Binding Macromolecules as Antagonists | Murali Ramanathan |
| 91-96 | Pharmacokinetic-Pharmacodynamic Modeling of the Antibiotic Effect of Piperacillin in Vitro | Arno Nolting, Teresa Dalla Costa, Kenneth H. Rand and Hartmut Derendorf |
| 97-101 | Interspecies Scaling of Bosentan, A New Endothelin Receptor Antagonist and Integration of in Vitro Data into Allometric Scaling | Thierry Lave, Philippe Coassolo, Geneviève Ubeaud, Roger Brandt and Christophe Schmitt, et al. |
| 102-107 | Enteral Bioavailability of Human Granulocyte Colony Stimulating Factor Conjugated with Poly(ethylene glycol) | Kathleen E. Jensen-Pippo, K. Lane Whitcomb, Randolph B. DePrince, Lloyd Ralph and Alan D. Habberfield |
| 108-113 | Determining Intestinal Metabolism and Permeability for Several Compounds in Rats. Implications on Regional Bioavailability in Humans | Patrick J. Sinko and Peidi Hu |
| 114-119 | Intestinal Absorption Barriers and Transport Mechanisms, Including Secretory Transport, for a Cyclic Peptide, Fibrinogen Antagonist | Bruce J. Aungst and Hiroshi Saitoh |
| 120-123 | In Vitro Permeability Through Caco-2 Cells is not Quantitatively Predictive of in Vivo Absorption for Peptide-Like Drugs Absorbed via the Dipeptide Transporter System | Saeho Chong, Sandra A. Dando, Kathleen M. Soucek and Richard A. Morrison |
| 124-128 | First-Pass Metabolism of Diltiazem in Anesthetized Rabbits: Role of Extrahepatic Organs | Marc Lefebvre, Walid Homsy, Gilles Caillé and Patrick du Souich |
| 129-136 | Atom Level Electrotopological State Indexes in QSAR: Designing and Testing Antithyroid Agents | Rafiq R. A. Abou-Shaaban, Hamad A. Al-Khamees, Hisham S. Abou-Auda and Anthony. P. Simonelli |
| 137-140 | FK506 (Tacrolimus) and Its Immunoreactive Metabolites in Whole Blood of Liver Transplant Patients and Subjects with Mild Hepatic Dysfunction | Yuji Tokunaga and Ala M. Alak |
| 141-145 | Liposomal Methylprednisolone in Rats: Dose-Proportionality and Chronic-Dose Pharmacokinetics/Pharmacodynamics | Elena V. Mishina and William J. Jusko |
| 146-150 | Maltodextrins as Lyoprotectants in the Lyophilization of a Model Protein, LDH | Sam Corveleyn and Jean-Paul Remon |
| 151-154 | Polymorphism of Sulfanilamide: (II) Stability Hierarchy of α-, β- and γ- Forms from Energy Calculations by the Atom-Atom Potential Method and from the Construction of the p, T Phase Diagram | S. Toscani, A. Dzyabchenko, V. Agafonov, J. Dugué and R. Céolin |
| 155-162 | Effect of Change in Shape Factor of a Single Crystal on Its Dissolution Behavior | Mandar V. Dali and J. T. Carstensen |
| 163-167 | Estimation of the Increase in Solubility of Drugs as a Function of Bile Salt Concentration | Sabena D. Mithani, Vassiliki Bakatselou, Christopher N. TenHoor and Jennifer B. Dressman |
| 168-172 | Percutaneous Absorption of Ketoprofen from Different Anatomical Sites in Man | Ajit K. Shah, Greg Wei, Robert C. Lanman, Vijay O. Bhargava and Scott J. Weir |
| 173-178 | The Effect of Octanoic Acid on the Binding of the Enantiomers of Ibuprofen and Naproxen to Human Serum Albumin: A Chromatographic Implication | Vandana K. Cheruvallath, Christopher M. Riley, Sunanda R. Narayanan, Siegfried Lindenbaum and John H. Perrin |
| 179-182 | Triazolines 34. Structure and Stability Relationships of Novel Δ2-l,2,3-Triazoline Anticonvulsants | Albert H. L. Chow, Francis C. K. Chiu, L. A. Damani and Pankaja K. Kadaba |
| 183 | ERRATUM |
| 185 | WHAT ARE THE DIFFERENCES BETWEEN A REQUEST FOR APPLICATION (RFA) AND A PROGRAM ANNOUNCEMENT (PA)? WHAT ARE THE ADVANTAGES AND DISADVANTAGES OF EACH? | Rochelle M. Long |
| 186-195 | Erythrocytes and the Transport of Drugs and Endogenous Compounds | Martin S. Highley and Ernst A. De Bruijn |
| 196-201 | Temperature and pH-sensitive Polymers for Human Calcitonin Delivery | Anne Serres, Miroslav Baudyš and Sung Wan Kim |
| 202-209 | The Influence of Sodium Glycocholate and Other Additives on the in vivo Transfection of Plasmid DNA in the Lungs | Daniel J. Freeman and Ralph W. Niven |
| 210-215 | Water-in-Oil Microemulsions Containing Medium-chain Fatty Acids/Salts: Formulation and Intestinal Absorption Enhancement Evaluation | Panayiotis P. Constantinides, Gus Welzel, Harma Ellens, Philip L. Smith and Sandra Sturgis, et al. |
| 216-221 | Comparison of HT29-18-C1 and Caco-2 Cell Lines as Models for Studying Intestinal Paracellular Drug Absorption | Andrew Collett, Erika Sims, David Walker, Yan-Ling He and John Ayrton, et al. |
| 222-226 | Oral Delivery of Sodium Cromolyn: Preliminary Studies In Vivo and In Vitro | Andrea Leone-Bay, Harry Leipold, Donald Sarubbi, Bruce Variano and Theresa Rivera, et al. |
| 227-233 | Effects of Structural Modifications on the Intestinal Permeability of Angiotensin II Receptor Antagonists and the Correlation of In Vitro, In Situ, and In Vivo Absorption | Maria D. Ribadeneira, Bruce J. Aungst, Charles J. Eyermann and Shiew-Mei Huang |
| 234-237 | Near-Infrared Spectroscopic Monitoring of the Film Coating Process | John D. Kirsch and James K. Drennen |
| 238-242 | Aggregation of rhDNase Occurred During the Compression of KBr Pellets Used for FTIR Spectroscopy | Hak-Kim Chan, Boonsri Ongpipattanakul and Jacky Au-Yeung |
| 243-249 | Development of a Stable Freeze-dried Formulation of Recombinant Human Interleukin-1 Receptor Antagonist | Byeong S. Chang, Gail Reeder and John F Carpenter |
| 250-255 | Oxidative Degradation of Antiflammin 2 | Jennifer M. Ye and Janet L. Wolfe |
| 256-264 | The Interaction of Charged and Uncharged Drugs with Neutral (HP-β-CD) and Anionically Charged (SBE7-β-CD) β-Cyclodextrins | Kazuto Okimoto, Roger A. Rajewski, Kaneto Uekama, Janan A. Jona and Valentino J. Stella |
| 265-271 | Interaction Between Superoxide Dismutase and Dipalmitoylphosphotidylglycerol Bilayers: A Fourier Transform Infrared (FT-IR) Spectroscopic Study | Yu-Li Lo and Yueh-Erh Rahman |
| 272-278 | Formulation and Antitumor Activity Evaluation of Nanocrystalline Suspensions of Poorly Soluble Anticancer Drugs | E. Merisko-Liversidge, P. Sarpotdar, J. Bruno, S. Hajj and L. Wei, et al. |
| 279-283 | The Effects of Ageing on the Rheological, Dielectric and Mucoadhesive Properties of Poly(Acrylic Acid) Gel Systems | Slobodanka Tamburic and Duncan Q. M. Craig |
| 284-289 | Pharmacokinetic Analysis and Antiepileptic Activity of Tetra-Methylcyclopropane Analogues of Valpromide | Meir Bialer, Salim Hadad, Bashier Kadry, Ali Abdul-Hai and Abdulla Haj-Yehia, et al. |
| 290-295 | Transport of Dopamine at the Blood-Brain Barrier of the Guinea Pig: Inhibition by Psychotropic Drugs and Nicotine | Cynthia L. Martel, Jasmina B. Mackic, James D. Adams, J. Gordon McComb and Martin H. Weiss, et al. |
| 296-300 | Analgesic and Immunomodulatory Effects of Codeine and Codeine 6-glucuronide | Vinayak Srinivasan, Donna Wielbo, James Simpkins, Janet Karlix and Kenneth Sloan, et al. |
| 301-304 | Effect of Cimetidine on the Pharmacokinetics and Pharmacodynamics of Chlorpheniramine and Diphenhydramine in Rabbits | Keith J. Simons, Xueyu Chen, Terry G. Eraser and F. Estelle R. Simons |
| 305-310 | Enhanced Tumor Delivery and Antitumor Activity of Palmitoyl Rhizoxin Using Stable Lipid Emulsions in Mice | Atsushi Kurihara, Yoko Shibayama, Atsuko Mizota, Akiko Yasuno and Masaru Ikeda, et al. |
| 311-315 | Polyester Nanocapsules as New Topical Ocular Delivery Systems for Cyclosporin A | Pilar Calvo, Alejandro Sánchez, Jesús Martínez, María Isabel López and Margarita Calonge, et al. |
| 316-323 | Ion-Pairing Interactions between 99MTc-Based Myocardial Imaging Agents and Oleic Acid | Charles M. Heard and Jonathan Hadgraft |
| 324-328 | Tmax: An Unconfounded Metric for Rate of Absorption in Single Dose Bioequivalence Studies | Rodney P. Basson, Benito J. Cerimele, Karl A. DeSante and Daniel C. Howey |
| 329-333 | Kinetics of Swelling of Compressed Cellulose Matrices: A Mathematical Model | Tamotsu Koizumi, Suwannee P. Panomsuk, Tomomi Hatanaka and Kazunori Katayama |
| 335-343 | Lipophilicity in Molecular Modeling | Bernard Testa, Pierre-Alain Carrupt, Patrick Gaillard, Frédéric Billois and Peter Weber |
| 344-351 | Targeted Drug Delivery for Boron Neutron Capture Therapy | Samir C. Mehta and D. Robert Lu |
| 352-359 | Preparation and Characterization of Doxorubicin-Loaded Sterically Stabilized Immunoliposomes | Noam Emanuel, Eli Kedar, Elijah M. Bolotin, Nechama I. Smorodinsky and Yechezkel Barenholz |
| 360-367 | A Novel Method of Preparing PLGA Microcapsules Utilizing Methylethyl Ketone | Hongkee Sah, Melissa S. Smith and Rey T. Chern |
| 368-375 | Development of a Polymeric Surgical Paste Formulation for Taxol | Charles I. Winternitz, John K. Jackson, Ann Marie Oktaba and Helen M. Burt |
| 376-380 | Structure and Behavior in Hydrophilic Matrix Sustained Release Dosage Forms: 4. Studies of Water Mobility and Diffusion Coefficients in the Gel Layer of HPMC Tablets Using NMR Imaging | Ali R. Rajabi-Siahboomi, Richard W. Bowtell, Peter Mansfield, Martyn C. Davies and Colin D. Melia |
| 381-386 | Determination of Tablet Coating Distribution by Deconvolution of Uncoated and Coated Tablet Weight Distributions | Ji Zhou, Todd Williams, Herman Swopes and Thomas Hale |
| 387-390 | Relationship Between Drug Percolation Threshold and Particle Size in Matrix Tablets | Isidore Caraballo, Mónica Millan and Antonio María Rabasco |
| 391-397 | A Cascade Impactor Entry Port for MDI Sprays with Collection Characteristics Imitating a Physical Model of the Human Throat | Nicholas C. Miller and Annette M. Purrington |
| 398-403 | The Simultaneous Estimation of the Influx and Efflux Blood-Brain Barrier Permeabilities of Gabapentin Using a Microdialysis-Pharmacokinetic Approach | Yanfeng Wang and Devin R Welty |
| 404-410 | Evaluation of Adjuvants that Enhance the Effectiveness of Antisense Oligodeoxynucleotides | J. A. Hughes, A. I. Aronsohn, A. V. Avrutskaya and R. L. Juliano |
| 411-420 | Transdermal Drug Delivery Using Low-Frequency Sonophoresis | Samir Mitragotri, Daniel Blankschtein and Robert Langer |
| 421-426 | Non Steady-state Descriptions of Drug Permeation Through Stratum Corneum. I. The Biphasic Brick-and-Mortar Model | Michael Heisig, Renate Lieckfeldt, Gabriel Wittum, George Mazurkevich and Geoffrey Lee |
| 427-432 | Theoretical Design of Prodrug-Enhancer Combination Based on a Skin Diffusion Model: Prediction of Permeation of Acyclovir Prodrugs Treated with l-Geranylazacycloheptan-2-one | Hiroto Bando, Toshihide Takagi, Fumiyoshi Yamashita, Yoshinobu Takakura and Mitsuru Hashida |
| 433-439 | Effect of Nonionic Surfactant on Transport of Model Drugs in Emulsions | Kyung Ae Yoon and Diane J. Burgess |
| 440-444 | Effect of Food on the Bioavailability of SDZ DJN 608, an Oral Hypoglycemic Agent, from a Tablet and a Liquid-Filled Capsule in the Dog | Francis L. S. Tse, D. Labbadia, K. Habucky, A. Karara and S. Au |
| 445-448 | Pharmacokinetics, Bioavailability, and Safety of Montelukast Sodium (MK-0476) in Healthy Males and Females | Haiyung Cheng, Jonathan A. Leff, Raju Amin, Barry J. Gertz and Marina De Smet, et al. |
| 449-452 | The Effect of Probenecid on the Pharmacokinetics of Zalcitabine in HIV-Positive Patients | J. W. Massarella, L. A. Nazareno, S. Passe and B. Min |
| 453-456 | Absorption Rate Vs. Exposure: Which Is More Useful for Bioequivalence Testing? | Thomas N. Tozer, Frédéric Y. Bois, Walter W. Hauck, Mei-Ling Chen and Roger L. Williams |
| 457-461 | Nicanartine Improves in Vitro Resistance of Lipoproteins to Oxidation | Eric Dailly, Saïk Urien, Petra Wülfroth and Jean Paul Tillement |
| 462-468 | Differences in Lipoprotein Concentration and Composition Modify the Plasma Distribution of Free and Liposomal Annamycin | Kishor M. Wasan and Richard E. Morton |
| 469-475 | Derivatives of Dexanabinol. II. Salts of Amino Acid Esters Containing Tertiary and Quaternary Heterocyclic Nitrogen with Increased Water-Solubility | Emil Pop, Ferenc Soti, Marcus E. Brewster, Yechezkel Barenholz and Veronica Korablyov, et al. |
| 476-480 | Anti-Inflammatory and Antishock Water-Soluble Polyesters of Glucocorticoids with Low Level Systemic Toxicity | Serguei L. Timofeevski, Evgeny F. Panarin, Oleg L. Vinogradov and Michail V. Nezhentsev |
| 481-484 | Characterization of the Salts of a Cyclic RGB Peptide | Michael B. Maurin, Susan M. Rowe, Arlene Rockwell, C. M. Foris and Munir A. Hussain |
| 485-487 | pH-Sensitive Nanoparticles: An Effective Means to Improve the Oral Delivery of HIV-1 Protease Inhibitors in Dogs | Jean-Christophe Leroux, Robert M. Cozens, Johannes L. Roesel, Bruno Galli and Eric Doelker, et al. |
| 489-496 | Microtubule-based Motor Proteins: New Targets for Enhancing Drug Delivery? | Sarah F. Hamm-Alvarez |
| 497-513 | Recent Advances in Carrier-mediated Hepatic Uptake and Biliary Excretion of Xenobiotics | Masayo Yamazaki, Hiroshi Suzuki and Yuichi Sugiyama |
| 514-522 | Evidence for Intestinal Secretion as an Additional Clearance Pathway of Talinolol Enantiomers: Concentration- and Dose-dependent Absorption in Vitro and in Vivo | Ulrike Wetterich, Hildegard Spahn-Langguth, Ernst Mutschler, Bernd Terhaag and Wolfgang Rösch, et al. |
| 523-527 | Characterization of the Transport Properties of a Quinolone Antibiotic, Fleroxacin, in Rat Choroid Plexus | Tsuyoshi Ooie, Hiroshi Suzuki, Tetsuya Terasaki and Yuichi Sugiyama |
| 528-534 | The Use of Surfactants to Enhance the Permeability of Peptides Through Caco-2 Cells by Inhibition of an Apically Polarized Efflux System | Manoj M. Nerurkar, Philip S. Burton and Ronald T. Borchardt |
| 535-541 | Diffusivity of Bile Salt/Phospholipid Aggregates in Mucin | Ching-Yuan Li, Cheryl L. Zimmerman and Timothy S. Wiedmann |
| 542-546 | The Relative Effect of Azone® and Transcutol® on Permeant Diffusivity and Solubility in Human Stratum Corneum | Julian E. Harrison, Adam C. Watkinson, Darren M. Green, Jonathan Hadgraft and Keith Brain |
| 547-552 | Response Surface Method: A Novel Strategy to Optimize lontophoretic Transdermal Delivery of Thyrotropin-releasing Hormone | Yi-You Huang, Shian-Min Wu and Cheng-Yi Wang |
| 553-558 | Iontophoresis of Bases, Nucleosides, and Nucleotides | Ronald van der Geest, Frédérique Hueber, Francis C. Szoka and Richard H. Guy |
| 559-565 | Transdermal Delivery of Fentanyl by Electroporation I. Influence of Electrical Factors | Rita Vanbever, Eric Le Boulengé and Véronique Préat |
| 566-569 | Theoretical Considerations on Two Equations for Estimating the Extent of Absorption After Oral Administration of Drugs | Younggil Kwon and Philip B. Inskeep |
| 570-576 | Analysis of Intestinal Perfusion Data for Highly Permeable Drugs Using a Numerical Aqueous Resistance—Nonlinear Regression Method | P. J. Sinko, G. D. Leesman, A. P. Waclawski, H. Yu and J. H. Kou |
| 577-582 | Effects of Transfection with the Cu, Zn-Superoxide Dismutase Gene on Xanthine/Xanthine Oxidase-Induced Cytotoxicity in Fibroblasts from Rat Skin | Kohshi Nishiguchi, Kazue Ishida, Masanori Nakajima, Tetsuo Maeda and Fusao Komada, et al. |
| 583-587 | The Effect of Formulation on the Antimicrobial Activity of Cetylpyridinium Chloride in Candy Based Lozenges | R. Michael E. Richards, James Z. Xing and Lindsay F. C. Weir |
| 588-593 | Preparation and Characterization of Freeze-dried Chitosan-Poly(Ethylene Oxide) Hydrogels for Site-Specific Antibiotic Delivery in the Stomach | Vijay R. Patel and Mansoor M. Amiji |
| 594-598 | Relationship Between Gelation Rate of Controlled-release Acetaminophen Tablets Containing Polyethylene Oxide and Colonic Drug Release in Dogs | Kazuhiro Sako, Hiroshi Nakashima, Toyohiro Sawada and Muneo Fukui |
| 599-603 | Disposition Characteristics of Plasmid DNA in the Single-pass Rat Liver Perfusion System | Mitsunobu Yoshida, Ram I. Mahato, Kenji Kawabata, Yoshinobu Takakura and Mitsuru Hashida |
| 604-610 | Immunoliposomes as Enzyme-Carriers (Immuno-Enzymosomes) for Antibody-Directed Enzyme Prodrug Therapy (ADEPT): Optimization of Prodrug Activating Capacity | Monique H. Vingerhoeds, Hidde J. Haisma, Sheila O. Belliot, Roefke H. P. Smit and Daan J. A. Crommelin, et al. |
| 611-615 | Determination of R(+)- and S(–)-Lansoprazole Using Chiral Stationary-Phase Liquid Chromatography and Their Enantioselective Pharmacokinetics in Humans | Hisakazu Katsuki, Hatsumi Yagi, Kazuhiko Arimori, Chizuko Nakamura and Masahiro Nakano, et al. |
| 616-621 | Use of Near-Infrared Spectroscopy to Evaluate an Active in a Film Coated Tablet | Bruce R. Buchanan, Mark A. Baxter, T.-Show Chen, Xue-Zhi Qin and Priscilla A. Robinson |
| 622-627 | The Binding of Cyclosporin A to Human Plasma: An in Vitro Microdialysis Study | Hua Yang and William F. Elmquist |
| 628-632 | Pharmacokinetic Interaction Between Intravenous 2′,3′-Dideoxyinosine and Pentamidine in Rats | Teng-Kuang Yeh, Hyo-Jeong K. Kang, M. Guillaume Wientjes and Jessie L.-S. Au |
| 633-638 | Synergistic Effect of Electric Field and Ultrasound on Transdermal Transport | Joseph Kost, Uwe Pliquett, Samir Mitragotri, Aye Yamamoto and Robert Langer, et al. |
| 639-642 | Effects on the Pharmacokinetics and Pharmacodynamics in the Elderly of Coadministering Ramipril with Water, Apple Juice, and Applesauce | I-Der Lee, Thomas L. Hunt, Charles R. Bradley, Carol Copp and Lynne Griffiths, et al. |
| 643-646 | The Effect of the Reconstitution Medium on Aggregation of Lyophilized Recombinant Interleukin-2 and Ribonuclease A | Mei Z. Zhang, Katherine Pikal, Thai Nguyen, Tsutomu Arakawa and Steven J. Prestrelski |
| 647 | ERRATUM |
| 649-662 | Blood Radicals: Reactive Nitrogen Species, Reactive Oxygen Species, Transition Metal Ions, and the Vascular System | Victor Darley-Usmar and Barry Halliwell |
| 663-670 | A Fractal Approach to Heterogeneous Drug Distribution: Calcium Pharmacokinetics | Panos Macheras |
| 671-682 | Chemotherapeutic Drugs Released from Polymers: Distribution of 1,3-bis(2-chloroethyl)-l-nitrosourea in the Rat Brain | Lawrence K. Fung, Marian Shin, Betty Tyler, Henry Brem and W. Mark Saltzman |
| 683-691 | Morphological Characterization of Polyanhydride Biodegradable Implant Gliadel® During in Vitro and in Vivo Erosion Using Scanning Electron Microscopy | Wenbin Dang, Todd Daviau and Henry Brem |
| 692-700 | Deformation Kinetics Analysis of Polymeric Matrices | Susan K. Lum and Wendy C. Duncan-Hewitt |
| 701-709 | Polyvinyl Derivatives as Novel Interactive Polymers for Controlled Gene Delivery to Muscle | Russell J. Mumper, John G. Duguid, Khursheed Anwer, Melisa K. Barron and Hiroaki Nitta, et al. |
| 710-717 | Effects of Polyethyleneglycol Chain Length and Phospholipid Acyl Chain Composition on the Interaction of Polyethyleneglycol-phospholipid Conjugates with Phospholipid: Implications in Liposomal Drug Delivery | Frank K. Bedu-Addo, P. Tang, Y. Xu and Leaf Huang |
| 718-724 | Interaction of Polyethyleneglycol-Phospholipid Conjugates with Cholesterol-Phosphatidylcholine Mixtures: Sterically Stabilized Liposome Formulations | R K. Bedu-Addo, P. Tang, Y. Xu and L. Huang |
| 725-728 | Fat Emulsions Based on Structured Lipids (1,3-specific triglycerides): An Investigation of the in Vivo Fate | Marine Hedeman, Helle Brøndsted, Annette Müllertz and Sven Frokjaer |
| 729-733 | In Vivo ESR Studies on Pharmacokinetics and Metabolism of Parenteral Lipid Emulsion in Living Mice | Tetsuo Yamaguchi, Shigeru Itai, Hidefumi Hayashi, Seiji Soda and Akira Hamada, et al. |
| 734-738 | Delivery of Nasal Powders of β-Cyclodextrin by Insufflation | Alessia De Ascentiis, Ruggero Bettini, Giovanni Caponetti, Pier Luigi Catellani and Maria Teresa Peracchia, et al. |
| 739-743 | Enhancement of Nasal Salmon Calcitonin Absorption by Lauroylcarnitine Chloride in Rats | Seiya Kagatani, Tatsuki Shinoda, Muneo Fukui, Tadayoshi Ohmura and Shunji Hasumi, et al. |
| 744-748 | Pulmonary First-Pass and Steady-State Metabolism of Phenols | Paul A. Dickinson and Glyn Taylor |
| 749-755 | Methanol Inhalation: Site and Other Factors Influencing Absorption, and an Inhalation Toxicokinetic Model for the Rat | Robert A. Perkins, Keith W. Ward and Gary M. Pollack |
| 756-761 | Effects of Additives on Heat Denaturation of rhDNase in Solutions | Hak-Kim Chan, Kwok-Leung Au-Yeung and Igor Gonda |
| 762-769 | Isolation and Characterization of a Monomethioninesulfoxide Variant of Interferon α-2b | Gerry Gitlin, Anthony Tsarbopoulos, Suman T. Patel, Wasyl Sydor and Birendra N. Pramanik, et al. |
| 770-774 | Skin Penetration and Sun Protection Factor of Ultra-Violet Filters from Two Vehicles | P. Treffel and B. Gabard |
| 775-778 | Predicting Blood-Brain Transport of Drugs: A Computational Approach | Subhash C. Basak, Brian D. Gute and Lester R. Drewes |
| 779-783 | Vaginal Permeability and Enzymatic Activity Studies in Normal and Ovariectomized Rabbits | Füsun Acartürk and Joseph R. Robinson |
| 784-793 | Acute Gastrointestinal Toxic Effects of Suspensions of Unencapsulated and Encapsulated Ibuprofen in Rats | Christianah Moji Adeyeye, J. Douglas Bricker, Vinod D. Vilivalam and William I. Smith |
| 794-797 | Interspecies Pharmacokinetics of a Novel Hematoregulatory Peptide (SK&F 107647) in Rats, Dogs, and Oncologic Patients | Dion R. Brocks, Martin I. Freed, David E. Martin, Teresa S. Sellers and Nabeel Mehdi, et al. |
| 798-800 | Iontophoresis of Nafarelin Across Human Skin in Vitro | Amalia M. Rodríguez Bayón and Richard H. Guy |
| 801-803 | Evidence for the Existence of Insulin-Degrading Enzyme on the Brush-Border Membranes of Rat Enterocytes | Li-Ling Chang and Jane P. F. Bai |
| 804-808 | Hot Melt Extrusion of Acrylic Films | Carolyn Aitken-Nichol, Feng Zhang and James W. McGinity |
| 809-811 | Model for Moisture Transport into Inhalation Aerosols | James M. Reynolds and Daniel P. McNamara |
| 813-814 | WHAT ARE “REINVENTION ACTIVITIES”? HOW IS THE NIH PARTICIPATING? WHAT CHANGES CAN BE EXPECTED AT THE NIH? HOW CAN I GET CURRENT INFORMATION? | Rochelle M. Long Ph.D |
| 815-819 | Biomaterials Science at a Crossroads: Are Current Product Liability Laws in the United States Hampering Innovation and the Development of Safer Medical Implants? | Joachim Kohn |
| 820-831 | Macromolecular Carrier Systems for Targeted Drug Delivery: Pharmacokinetic Considerations on Biodistribution | Yoshinobu Takakura and Mitsuru Hashida |
| 832-838 | Population Pharmacokinetics of Terfenadine | Richard L. Lalonde, Denis Lessard and Jacques Gaudreault |
| 839-845 | Evaluation of Pharmacokinetic Studies: Is It Useful to Take into Account Concentrations Below the Limit of Quantification? | Henri Humbert, Marie Danièle Cabiac, José Barradas and Christophe Gerbeau |
| 846-850 | High Variability in Drug Pharmacokinetics Complicates Determination of Bioequivalence: Experience with Verapamil | Yu Chung Tsang, Radu Pop, Paul Gordon, John Hems and Michael Spino |
| 851-854 | lontophoretic Delivery of a Telomeric Oligonucleotide | Rhonda M. Brand and Patrick L. Iversen |
| 855-860 | Analysis of Simultaneous Transport and Metabolism of Ethyl Nicotinate in Hairless Rat Skin | Kenji Sugibayashi, Teruaki Hayashi, Tomio Hatanaka, Masahiko Ogihara and Yasunori Morimoto |
| 861-868 | Targeted Delivery of Doxorubicin via Sterically Stabilized Immunoliposomes: Pharmacokinetics and Biodistribution in Tumor-bearing Mice | Noam Emanuel, Eli Kedar, Elijah M. Bolotin, Nechama I. Smorodinsky and Yechezkel Barenholz |
| 869-874 | Erythrocytes as Carriers for Recombinant Human Erythropoietin | Marina-Inmaculada Garín, Rosa-María López, Silvia Sanz, Montserrat Pinilla and José Luque |
| 875-879 | Formulation of Polyiodinated Triglyceride Analogues in a Chylomicron Remnant-Like Liver-Selective Delivery Vehicle | Marc A. Longino, Douglas A. Bakan, Jamey P. Weichert and Raymond E. Counsell |
| 880-884 | Development and Pharmacokinetics of Galactosylated Poly-L-Glutamic Acid as a Biodegradable Carrier for Liver-Specific Drug Delivery | Hideki Hirabayashi, Makiya Nishikawa, Yoshinobu Takakura and Mitsuru Hashida |
| 885-890 | Age-dependent Expression of P-Glycoprotein gp17O in Caco-2 Cell Monolayers | Ken-ichi Hosoya, Kwang-Jin Kim and Vincent H. L. Lee |
| 891-895 | In Vivo Assessment of Intestinal, Hepatic, and Pulmonary First Pass Metabolism of Propofol in the Rat | Araz A. Raoof, Patrick R Augustijns and Roger K. Verbeeck |
| 896-901 | Enteral Absorption of Insulin in Rats from Mucoadhesive Chitosan-Coated Liposomes | Hirofumi Takeuchi, Hiromitsu Yamamoto, Toshiyuki Niwa, Tomoaki Hino and Yoshiaki Kawashima |
| 902-906 | Contribution of Lysosomes to the Subcellular Distribution of Basic Drugs in the Rat Liver | Junko Ishizaki, Koichi Yokogawa, Masako Hirano, Emi Nakashima and Yoshimichi Sai, et al. |
| 907-913 | Solubilization of Retinoids by Bile Salt/ Phospholipid Aggregates | Ching-Yuan Li, Cheryl L. Zimmerman and Timothy S. Wiedmann |
| 914-919 | Permeation Behavior of Salbutamol Sulfate Through Hydrophilic and Hydrophobic Membranes Embedded by Thermo-responsive Cholesteryl Oleyl Carbonate | Shan-Yang Lin, Yih-Yih Lin and Ko-Shao Chen |
| 920-925 | The Effect of Hydrophobic Character of Drugs and Helix-coil Transition of κ-Carrageenan on the Polyelectrolyte-drug Interaction | Ninus Caram-Lelham and Lars-Olof Sundelöf |
| 926-930 | Determination of Molecular Mobility of Lyophilized Bovine Serum Albumin and γ-Globulin by Solid-State 1H NMR and Relation to Aggregation-Susceptibility | Suraie Yoshioka, Yukio Aso and Shigeo Kojima |
| 931-938 | Effects of Polyaminocarboxylate Metal Chelators on Iron-thiolate Induced Oxidation of Methionine- and Histidine-Containing Peptides | Fang Zhao, Jian Yang and Christian Schöneich |
| 939-943 | Synthesis and Anti-proliferative Activity of 2-Hydroxy-l,2-dihydroacronycine Glycosides | Sofia Mitaku, Alexios-Léandros Skaltsounis, François Tillequin, Michel Koch and Yves Rolland, et al. |
| 944-949 | Investigations into the Relationship Between Drug Properties, Filling, and the Release of Drugs from Hard Gelatin Capsules Using Multivariate Statistical Analysis | James Hogan, Pei-Inn Shue, Fridrun Podczeck and J. Michael Newton |
| 950-951 | Effect of the Spermicide, Nonoxynol 9, on Vaginal Permeability in Normal and Ovariectomized Rabbits | Füsun Acatürk and Joseph R. Robinson |
| 952-956 | Primary Cell Culture of the Rabbit Choroid Plexus: An Experimental System to Investigate Membrane Transport | Vikram K. Ramanathan, Andrew C. Hui, Claire M. Brett and Kathleen M. Giacomini |
| 957-960 | The Effect of Iontophoresis on Skin Barrier Integrity: Non-invasive Evaluation by Impedance Spectroscopy and Transepidermal Water Loss | Yogeshvar N. Kalia, Lourdes B. Nonato and Richard H. Guy |
| 961 | ERRATUM |
| 963-977 | Carrier-Mediated Intestinal Transport of Drugs | Akira Tsuji and Ikumi Tamai |
| 978-988 | In-vitro Cell Culture Models of the Nasal Epithelium: A Comparative Histochemical Investigation of Their Suitability for Drug Transport Studies | Ute Werner and Thomas Kissel |
| 989-995 | Characterization of Glucose Dependent Gel-Sol Phase Transition of the Polymeric Glucose-Concanavalin A Hydrogel System | Aiman A. Obaidat and Kinam Park |
| 996-1002 | Characterization and Stability of N-terminally PEGylated rhG-CSF | Olaf B. Kinstler, David N. Brems, Scott L. Lauren, Amiee G. Paige and James B. Hamburger, et al. |
| 1003-1007 | Computer Simulation of Crystal-liquid Interface: Application to Wettability of Solids | Jamshed Anwar and Sohrab Khoshkhoo |
| 1008-1014 | Evidence for the Formation of Amphotericin B-phospholipid Complexes in Langmuir Monolayers | Martin R. Lance, Clive Washington and Stanley S. Davis |
| 1015-1019 | Mode of Interaction of Loop Diuretics with Human Serum Albumin and Characterization of Binding Site | Norito Takamura, Akihiko Haruta, Hirofumi Kodama, Michio Tsuruoka and Keishi Yamasaki, et al. |
| 1020-1027 | Percutaneous Absorption of Biologically-Active Interferon-gamma in a Human Skin Graft-Nude Mouse Model | Sarah M. Short, Brian D. Paasch, Jason H. Turner, Norman Weiner and Ann L. Daugherty, et al. |
| 1028-1037 | Interactions of Phosphodiester and Phosphorothioate Oligonucleotides with Intestinal Epithelial Caco-2 Cells | G. F. Beck, W. J. Irwin, P. L. Nicklin and S. Akhtar |
| 1038-1042 | Effect of Size and Serum Proteins on Transfection Efficiency of Poly ((2-dimethylamino)ethyl Methacrylate)-Plasmid Nanoparticles | Jong-Yuh Cherng, Petra van de Wetering, Herre Talsma, Daan J. A. Crommelin and Wim E. Hennink |
| 1043-1048 | Transcription Regulation of Rat Glutathione S-Transferase Ya Subunit Gene Expression by Chemopreventive Agents | Peiwen Fei, George A. Matwyshyn, Thomas H. Rushmore and Ah-Ng Tony Kong |
| 1049-1054 | Species Difference in the Disposition of Liposomes Among Mice, Rats, and Rabbits: Allometric Relationship and Species Dependent Hepatic Uptake Mechanism | H. Harashima, S. Komatsu, S. Kojima, C. Yanagi and Y. Morioka, et al. |
| 1055-1058 | The Role of Serum Complement on the Organ Distribution of Intravenously Administered Poly (methyl methacrylate) Nanoparticles: Effects of Pre-Coating with Plasma and with Serum Complement | Gerrit Borchard and Jörg Kreuter |
| 1059-1064 | In Vitro and in Vivo Evaluation in Rabbits of a Controlled Release 5-fluorouracil Subconjunctival Implant Based on Poly(D,L-lactide-co-glycolide) | Guangji Wang, Ian G. Tucker, Michael S. Roberts and Lawrence W. Hirst |
| 1065-1068 | Kinetics of Quinolone Antibiotics in Rats: Efflux from Cerebrospinal Fluid to the Circulation | Tsuyoshi Ooie, Hiroshi Suzuki, Tetsuya Terasaki and Yuichi Sugiyama |
| 1069-1072 | Modulation of Organic Cation Transport and Lipid Fluidity by Benzyl Alcohol in Rat Renal Brush-border Membranes | Tomohiro Nabekura, Mikihisa Takano, Michio Kimura, Masato Yasuhara and Ken-ichi Inui |
| 1073-1077 | Effect of Cyclosporin Analogues and FK506 on Transcellular Transport of Daunorubicin and Vinblastine via P-glycoprotein | Kumiko Tanaka, Midori Hirai, Yusuke Tanigawara, Masato Yasuhara and Ryohei Hori, et al. |
| 1078-1082 | Suitability of Enalapril as a Probe of the Dipeptide Transporter System: InVitro and In Vivo Studies | Richard A. Morrison, Saeho Chong, Anthony M. Marino, Martin A. Wasserman and Peter Timmins, et al. |
| 1083-1087 | Improved Oral Delivery of Desmopressin via a Novel Vehicle: Mucoadhesive Submicron Emulsion | Ehud Ilan, Shimon Amselem, Michael Weisspapir, Joseph Schwarz and Ayala Yogev, et al. |
| 1088-1094 | Development and Validation of Two Solid-Phase Enzyme Immunoassays (ELISA) for Quantitation of Human Epidermal Growth Factors (hEGFs) | Nywana Sizemore, Richard C. Dudeck, Charles M. Barksdale, Gerald D. Nordblom and Williams T. Mueller, et al. |
| 1095-1104 | Determination of the Composition of Delavirdine Mesylate Polymorph and Pseudopolymorph Mixtures Using 13C CP/MAS NMR | Ping Gao |
| 1105-1108 | Serial Versus Sparse Sampling in Toxicokinetic Studies | Francis L. S. Tse and Jerry R. Nedelman |
| 1109-1115 | Bioequivalence of a Highly Variable Drug: An Experience with Nadolol | Robert G. Buice, Veerappan S. Subramanian, Kenneth L. Duchin and Samuel Uko-Nne |
| 1116-1121 | Bioequivalence: Individual and Population Compartmental Modeling Compared to the Noncompartmental Approach | Helen S. Pentikis, James D. Henderson, Nhan L. Tran and Thomas M. Ludden |
| 1122-1126 | Demonstration of Sucralfate-mediated Preservation of Growth Factor Bioactivity in the Presence of Low pH with a Human Gastric Epithelial Cell Line (AGS) | Huaibao Sheng, Praful K. Shah and Kenneth L. Audus |
| 1127-1129 | Study of the Influence of Several Stabilizing Agents on the Entrapment and InVitro Release of pBC 264 from Poly(Lactide-Co-Glycolide) Microspheres Prepared by a W/O/W Solvent Evaporation Method | María J. Blanco-Príeto, Eliana Leo, Florence Delie, Annette Gulik and Patrick Couvreur, et al. |
| 1130-1131 | BOOK REVIEWS |
| 1133-1141 | Natural Products as a Resource for New Drugs | Alice M. Clark |
| 1142-1153 | Solid-State Stability of Human Insulin I. Mechanism and the Effect of Water on the Kinetics of Degradation in Lyophiles from pH 2–5 Solutions | Robert G. Strickley and Bradley D. Anderson |
| 1154-1161 | Zinc Uptake in Five Sectors of the Rat Gastrointestinal Tract: Kinetic Study in the Whole Colon | Sonia Luz Gisbert-González and Francisca Torres-Molina |
| 1162-1167 | Stratum Corneum Lipids of Human Epidermal Keratinocyte Air-Liquid Cultures: Implications for Barrier Function | Alane H. Kennedy, Guia M. Golden, Carol L. Gay, Richard H. Guy and Michael L. Francoeur, et al. |
| 1168-1173 | The Influence of an Electric Field on Ion and Water Accessibility to Stratum Corneum Lipid Lamellae | Louk A. R. M. Pechtold, William Abraham and Russell O. Potts |
| 1174-1180 | Characterization of Interactions Between Bile Salts and Drugs by Micellar Electrokinetic Capillary Chromatography. Part I. | Maria A. Schwarz, Reinhard H. H. Neubert and Gerhard Dongowski |
| 1181-1185 | Dielectric Analysis of Phosphorylcholine Head Group Mobility in Egg Lecithin Liposomes | Geoff Smith, Boris Yu. Shekunov, Jie Shen, Alistair P. Duffy and Jamshed Anwar, et al. |
| 1186-1190 | Insight into the Lipophilicity of the Aromatic N-Oxide Moiety | Giulia Caron, Pierre-Alain Carrupt, Bernard Testa, Giuseppe Ermondi and Alberto Gasco |
| 1191-1195 | Correlation of Physicochemical Parameters to the Hydrophobic Contribution Constants of Amino Acid Residues in Small Peptides | Darshana Palekar, Michael Shiue and Eric J. Lien |
| 1196-1200 | Immunostimulating Polysaccharides from Panax notoginseng | Hua Gao, Fengzhen Wang, Eric J. Lien and Melvin D. Trousdale |
| 1201-1204 | Local Absorption Kinetics of Levofloxacin from Intestinal Tract into Portal Vein in Conscious Rat Using Portal-Venous Concentration Difference | Yusuke Fujieda, Kiyoshi Yamaoka, Takashi Ito and Terumichi Nakagawa |
| 1205-1209 | The Effect of Size on Uptake of Orally Administered Latex Microparticles in the Small Intestine and Transport to Mesenteric Lymph Nodes | Katharine E. Carr, Rosemary A. Hazzard, Shane Reid and Giséle M. Hodges |
| 1210-1212 | Pectin/Ethylcellulose Film Coating Formulations for Colonic Drug Delivery | Z. Wakerly, J. T. Fell, D. Attwood and D. Parkins |
| 1213-1218 | Metabolism, Uptake, and Transepithelial Transport of the Diastereomers of Val-Val in the Human Intestinal Cell Line, Caco-2 | Kiyoshi Tamura, Pradip K. Bhatnagar, Joanne S. Takata, Chao-Pin Lee and Philip L. Smith, et al. |
| 1219-1227 | Effects of Permeation Enhancers on the Transport of a Peptidomimetic Thrombin Inhibitor (CRC 220) in a Human Intestinal Cell Line (Caco-2) | Ute Werner, Thomas Kissel and Martin Reers |
| 1228-1232 | Buccal Absorption of Testosterone and Its Esters Using a Bioadhesive Tablet in Dogs | Jody Voorspoels, Jean-Paul Remon, Willy Eechaute and Walter De Sy |
| 1233-1237 | In Vivo Buccal Delivery of the Peptide Drug Buserelin with Glycodeoxycholate as an Absorption Enhancer in Pigs | A. Janet Hoogstraate, J. Coos Verhoef, Anton Pijpers, Leo A. M. G. van Leengoed and Jos H. M. Verheijden, et al. |
| 1238-1242 | Nitric Oxide (NO)-releasing Pathway of FK409 in the Presence of Sulfhydryl-bearing Compounds | Shinichi Fukuyama, Toshio Azuma, Yoshimi Hirasawa, Noritugu Morokoshi and Toshihiro Akama, et al. |
| 1243-1246 | Glucuronidation Metabolic Kinetics of Valproate in Guinea Pigs: Nonlinear at Clinical Concentration Levels | Hsiu-Ying Yu and Yu-Zen Shen |
| 1247-1251 | Transport of Drugs Across the Xenopus Pulmonary Membrane and Their Absorption Enhancement by Various Absorption Enhancers | Shigeki Okumura, Yoshimi Fukuda, Kanae Takahashi, Takuya Fujita and Akira Yamamoto, et al. |
| 1252-1257 | Oxidation of Human Insulin-like Growth Factor I in Formulation Studies: Kinetics of Methionine Oxidation in Aqueous Solution and in Solid State | Jonas Fransson, Ebba FIorin-Robertsson, Kent Axelsson and Christina Nyhlén |
| 1258-1264 | Excipient Interaction with Cetylpyridinium Chloride Activity in Tablet Based Lozenges | R. Michael E. Richards, James Z. Xing and Kirsty M. B. Mackay |
| 1265-1271 | The in Vitro Release of Some Antimuscarinic Drugs from Monoolein/ Water Lyotropic Liquid Crystalline Gels | Pauline B. Geraghty, David Attwood, John H. Collett and Yogesh Dandiker |
| 1272-1275 | High-Performance Liquid Chromatographic Analysis of Dipyrone Metabolites to Study Their Formation in Human Liver Microsomes | Gerd Geisslinger, Ronald Böcker and Micha Levy |
| 1276-1278 | Mechanisms of 5-Fluorouracil (5-FU) Transport in Isolated Rabbit Choroid Plexus Tissue Slices | Carla B. Washington and Kathleen M. Giacomini |
| 1279 | WHAT ARE THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) AND SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAMS? WHAT KINDS OF AWARDS ARE AVAILABLE? WHO CAN PARTICIPATE? HOW CAN I GET CURRENT INFORMATION AND AN APPLICATION? | Rochelle M. Long |
| 1280-1282 | Performance of Bailer's Method for AUC Confidence Intervals from Sparse Non-Normally Distributed Drug Concentrations in Toxicokinetic Studies | Sudhakar M. Pai, Jerry R. Nedelman, Gerald Hajian, Ekaterina Gibiansky and Vijay K. Batra |
| 1283-1290 | Characterization of AUCs from Sparsely Sampled Populations in Toxicology Studies | Sudhakar M. Pai, Scott H. Fettner, Gerald Hajian, Mitchell N. Cayen and Vijay K. Batra |
| 1291-1298 | A Reasoned Action Approach to Physicians' Utilization of Drug Information Sources | Caroline A. Gaither, Richard P. Bagozzi, Frank J. Ascione and Duane M. Kirking |
| 1299-1304 | Increasing Clients' Knowledge of Community Pharmacists' Roles | Betty Chewning and Jon C. Schommer |
| 1305-1312 | Differential Effect of Taxol in Rat Primary and Metastatic Prostate Tumors: Site-Dependent Pharmacodynamics | Wan-Ching Yen, M. Guillaume Wientjes and Jessie L.-S. Au |
| 1313-1316 | Steady-State Kinetics of Imipramine in Transgenic Mice with Elevated Serum AAG Levels | John W. Holladay, Michael J. Dewey and Sun D. Yoo |
| 1317-1321 | Covalent Binding Between Bucillamine Derivatives and Human Serum Albumin | Ryuichi Narazaki, Mizuho Hamada, Kumiko Harada and Masaki Otagiri |
| 1322-1326 | PC-2, Linear Homoglucan with α-linkages, Peripherally Enhances the Hippocampal Long-Term Potentiation | Miroslav Smriga, Hiroshi Saito, Shoji Shibata, Takao Narui and Toru Okuyama, et al. |
| 1327-1330 | Purification and Partial Characterization of an Indomethacin Hydrolyzing Enzyme from Pig Liver | Keisuke Terashima, Satomi Takai, Yoshiko Usami, Tetsuo Adachi and Tadashi Sugiyama, et al. |
| 1331-1335 | Horseradish Peroxidase Transport Across Rat Alveolar Epithelial Cell Monolayers | Yasuhisa Matsukawa, Hiroshi Yamahara, Vincent H. L. Lee, Edward D. Crandall and Kwang-Jin Kim |
| 1336-1342 | Comparison Between Permeability Coefficients in Rat and Human Jejunum | Urban Fagerholm, Monica Johansson and Hans Lennernäs |
| 1343-1347 | Transport of Alpha-Tocopherol and Its Derivatives Through Erythrocyte Membranes | Francesco Bonina, Maria Lanza, Lucia Montenegro, Loredana Salerno and Patrizia Smeriglio, et al. |
| 1348-1353 | Transdermal Permeation of Alniditan by Iontophoresis: In Vitro Optimization and Human Pharmacokinetic Data | Anne Jadoul, Jean Mesens, Wim Caers, Frank de Beukelaar and R. Crabbé, et al. |
| 1354-1359 | Passive Drug Diffusion via Standardized Skin Mini-erosion; Methodological Aspects and Clinical Findings with New Device | Paul Svedman, Stefan Lundin, Peter Höglund, Christer Hammarlund and Christer Malmros, et al. |
| 1360-1366 | Transdermal Delivery of Fentanyl by Electroporation II. Mechanisms Involved in Drug Transport | Rita Vanbever, Nathalie De Morre and Véronique Préat |
| 1367-1372 | Intracellular Distribution and Mechanism of Delivery of Oligonucleotides Mediated by Cationic Lipids | Olivier Zelphati and Francis C. Szoka |
| 1373-1377 | Comparison of Pharmacokinetic Parameters of a Polypeptide, the Bowman-Birk Protease Inhibitor (BBI), and Its Palmitic Acid Conjugate | Laura Honeycutt, Jeff Wang, Hossein Ekrami and Wei-Chiang Shen |
| 1378-1383 | Lectin-bearing Polymerized Liposomes as Potential Oral Vaccine Carriers | Hongming Chen, Vladimir Torchilin and Robert Langer |
| 1384-1388 | In Vitro-In Vivo Myotoxicity of Intramuscular Liposomal Formulations | Saleh A. Al-Suwayeh, Ian R. Tebbett, Donna Wielbo and Gayle A. Brazeau |
| 1389-1392 | Liposomal Induction of a Heat-stable Macrophage Priming Factor to Induce Nitric Oxide in Response to LPS | Yukihiko Aramaki, Hidetoshi Arima, Toshifumi Hara and Seishi Tsuchiya |
| 1393-1400 | Effects of Sugars and Polymers on Crystallization of Poly(ethylene glycol) in Frozen Solutions: Phase Separation Between Incompatible Polymers | Ken-ichi Izutsu, Sumie Yoshioka, Shigeo Kojima, Theodore W. Randolph and John F. Carpenter |
| 1401-1405 | Solubility Behavior, Phase Transition, and Structure-Based Nucleation Inhibition of Etanidazole in Aqueous Solutions | Michael B. Maurin, Susan M. Rowe, Kenneth S. Field, Robert C. Swintosky and Munir A. Hussain |
| 1406-1410 | Evidence for Phospholipid Bilayer Formation in Solid Lipid Nanoparticles Formulated with Phospholipid and Triglyceride | Hashem Heiati, Nigel C. Phillips and Rashad Tawashi |
| 1411-1416 | Atomic Force Microscopy Studies of Solid Lipid Nanoparticles | A. zur Mühlen, E. zur Mühlen, H. Niehus and W. Mehnert |
| 1417-1418 | Lack of Effect of Catheterization on the Pharmacokinetics of (-)-Carbovir in Rats | Cheryl L. Zimmerman, Kit J. Ha and Shu-hui Huang |
| 1419-1422 | A Cellular Automata Model of Micelle Formation | Lemont B. Kier, Chao-Kung Cheng, Bernard Testa and Pierre-Alain Carrupt |
| 1423 | ERRATUM |
| 1425-1426 | WHAT PROGRAM ANNOUNCEMENTS ARE CURRENTLY OPEN AT THE NIGMS? WHO ARE THE CONTACT PEOPLE? HOW CAN I GET MORE INFORMATION? | Rochelle M. Long |
| 1427-1437 | Design of Biological Equivalence Programs for Therapeutic Biotechnology Products in Clinical Development: A Perspective | Joyce Mordenti, Joy A. Cavagnaro and James D. Green |
| 1438-1444 | Pharmacokinetic Analysis of Drug Disposition After Intratumoral Injection in a Tissue-Isolated Tumor Perfusion System | Akira Saikawa, Takehiko Nomura, Fumiyoshi Yamashita, Yoshinobu Takakura and Hitoshi Sezaki, et al. |
| 1445-1452 | Design and Results of a Group Counter-detailing DUR Educational Program | Karen B. Farris, Duane M. Kirking, Leslie A. Shimp and Ruth Ann C. Opdycke |
| 1453-1459 | Intrinsic Solubility Estimation and pH-Solubility Behavior of Cosalane (NSC 658586), an Extremely Hydrophobic Diprotic Acid | Srinivasan Venkatesh, Jianmin Li, Yuehong Xu, Rao Vishnuvajjala and Bradley D. Anderson |
| 1460-1463 | Hydrotropic Solubilization— Mechanistic Studies | Renée E. Coffman and Dane O. Kildsig |
| 1464-1475 | Stable Formulations of Recombinant Human Growth Hormone and Interferon-γ for Microencapsulation in Biodegradable Mircospheres | Jeffrey L. Cleland and Andrew J. S. Jones |
| 1476-1481 | Oxidation of Human Insulin-Like Growth Factor I in Formulation Studies, II. Effects of Oxygen, Visible Light, and Phosphate on Methionine Oxidation in Aqueous Solution and Evaluation of Possible Mechanisms | Jonas Fransson and Anders Hagman |
| 1482-1487 | Synthesis, Antiinflammatory, and Cytotoxic Activities of 2-Alkyl and 2-Benzyl-2-Dimethylaminomethyl-5-(E)-Arylidene Cyclopentanone Hydrochlorides | Haitao Chen, Zhizhong Ji, Lan K. Wong, Jerome F. Siuda and Ven L. Narayanan |
| 1488-1494 | In Vitro and In Vivo Activity of 16,17-dehydro-epipregnanolones: 17,20-Bond Torsional Energy Analysis and D-ring Conformation | Michael B. Bolger, Scott Wieland, Jon E. Hawkinson, Haiji Xia and Ravindra Upasani, et al. |
| 1495-1500 | Structure-Activity Relationships for Substrates and Inhibitors of Mammalian Liver Microsomal Carboxylesterases | Tien L. Huang, Takahiro Shiotsuki, Tamon Uematsu, Babak Borhan and Qing X. Li, et al. |
| 1501-1506 | In Vitro-In Vivo Relationship of Oral Extended-Release Dosage Forms | Fang-Yu Liu, Nancy C. Sambol, Robert P. Giannini and Chui Yu Liu |
| 1507-1513 | Predicting Injection Site Muscle Damage I: Evaluation of Immediate Release Parenteral Formulations in Animal Models | Steven C. Sutton, Loreen A. F. Evans, Michelle T. S. Rinaldi and Kathy A. Norton |
| 1514-1518 | Predicting Injection Site Muscle Damage II: Evaluation of Extended Release Parenteral Formulations in Animal Models | Steven C. Sutton, Loreen A. F. Evans, Michelle T. S. Rinaldi and Kathy A. Norton |
| 1519-1523 | Permeation of Buprenorphine and Its 3-Alkyl-Ester Prodrugs Through Human Skin | Audra L. Stinchcomb, Anupam Paliwal, Rajesh Dua, Hirofumi Imoto and Ronald W. Woodard, et al. |
| 1524-1529 | Evaluation of Stereoselective Transdermal Transport and Concurrent Cutaneous Hydrolysis of Several Ester Prodrugs of Propranolol: Mechanism of Stereoselective Permeation | Shamim Ahmed, Teruko Imai and Masaki Otagiri |
| 1530-1534 | Influence of Vehicle, Distant Topical Delivery, and Biotransformation on the Chemopreventive Activity of Apigenin, a Plant Flavonoid, in Mouse Skin | Boyong Li, Heather Pinch and Diane R Birt |
| 1535-1540 | Absorption and Presystemic Metabolism of Selegiline Hydrochloride at Different Regions in the Gastrointestinal Tract in Healthy Males | Jeffrey S. Barrett, Peter Szego, Shashank Rohatagi, Richard J. Morales and Kimberly E. DeWitt, et al. |
| 1541-1546 | Effect of Destruction Force on Drug Release from Multiple Unit Controlled Release Dosage Forms in Humans | Noriko Katori, Wen-Shi Ma, Nobuo Aoyagi and Shigeo Kojima |
| 1547-1553 | A Novel Extravascular Input Function for the Assessment of Drug Absorption in Bioavailability Studies | Michael Weiss |
| 1554-1558 | The Relationship Between Rat Intestinal Permeability and Hydrophilic Probe Size | Majella E. Lane, Caitriona M. O'Driscoll and Owen I. Corrigan |
| 1559-1564 | Uptake Is the Rate-limiting Step in the Overall Hepatic Elimination of Pravastatin at Steady-state in Rats | Masayo Yamazaki, Sayoko Akiyama, Ryuichiro Nishigaki and Yuichi Sugiyama |
| 1565-1569 | Microdialysis Assessment of Microfibrous Collagen Containing a P-Glycoprotein-Mediated Transport Inhibitor, Cyclosporine A, for Local Delivery of Etoposide | Hitoshi Sato, Hidenori Kitazawa, Isao Adachi and Isamu Horikoshi |
| 1570-1575 | Fluconazole Distribution to the Brain: A Crossover Study in Freely-moving Rats Using In Vivo Microdialysis | Hua Yang, Qin Wang and William R Elmquist |
| 1576-1580 | Controlled Systemic Absorption and Increased Anesthetic Effect of Bupivacaine Following Epidural Administration of Bupivacaine-Hydroxypropyl-β-Cyclodextrin Complex | Jean Christophe Fréville, Gilles Dollo, Pascal Le Corre, François Chevanne and Roger Le Verge |
| 1581-1584 | Effect of Iontophoresis in Combination with Ionic Enhancers on the Lipid Structure of the Stratum Corneum: An X-ray Diffraction Study | Sophie Chesnoy, Jean Doucet, Dominique Durand and Guy Couarraze |
| 1585-1587 | Predicting Injection Site Muscle Damage III: Evaluation of Intramuscular Formulations in the L6 Cell Model | Loreen A. F. Evans, Paul E. Genereux, E. Michael Gibbs and Steven C. Sutton |
| 1589 | WHAT RESEARCH TRAINING OPPORTUNITIES ARE SPONSORED BY NIGMS AT THE NIH? HOW CAN I GET INFORMATION ABOUT THIS AND OTHER POSTDOCTORAL PROGRAMS AT THE NIH? | Rochelle M. Long |
| 1590-1594 | Evaluation of Orally Administered Highly Variable Drugs and Drug Formulations | Vinod P. Shah, Avraham Yacobi, William H. Barr, Leslie Z. Benet and Douwe Breimer, et al. |
| 1595-1614 | Pharmaceutical Approach to Somatic Gene Therapy | Fred D. Ledley |
| 1615-1623 | Esterase-Sensitive Cyclic Prodrugs of Peptides: Evaluation of an Acyloxyalkoxy Promoiety in a Model Hexapeptide | Giovanni M. Pauletti, Sanjeev Gangwar, Franklin W. Okumu, Teruna J. Siahaan and Valentine J. Stella, et al. |
| 1624-1630 | Structure-based Search for Peptide Ligands that Cross-react with Melanocortin Receptors | J. Mark Quillan and Wolfgang Sadée |
| 1631-1634 | Human Dipeptide Transporter, hPEPTl, Stably Transfected into Chinese Hamster Ovary Cells | Kuang-Ming Y. Covitz, Gordon L. Amidon and Wolfgang Sadée |
| 1635-1641 | Development of Caco-2 Cells Expressing High Levels of cDNA-Derived Cytochrome P4503A4 | Charles L. Crespi, Bruce W. Penman and Ming Hu |
| 1642-1646 | Effect of Non-Ionic Surfactants on the Formation of DNA/Emulsion Complexes and Emulsion-Mediated Gene Transfer | Feng Liu, Jingping Yang, Leaf Huang and Dexi Liu |
| 1647-1656 | Paclitaxel and Nocodazole Differentially Alter Endocytosis in Cultured Cells | Sarah F Hamm-Alvarez, Manisha Sonee, Kathleen Loran-Goss and Wei-Chiang Shen |
| 1657-1662 | The Effect of Conformation on Membrane Permeability of an Acyloxyalkoxy-linked Cyclic Prodrug of a Model Hexapeptide | Sanjeev Gangwar, Seetharama D. S. Jois, Teruna J. Siahaan, David G. Vander Velde and Valentine J. Stella, et al. |
| 1663-1667 | Metabolism, Uptake, and Transepithelial Transport of the Stereoisomers of Val-Val-Val in the Human Intestinal Cell Line, Caco-2 | Kiyoshi Tamura, Chao-Pin Lee, Philip L. Smith and Ronald T. Borchardt |
| 1668-1672 | Mucoadhesive Polymers in Peroral Peptide Drug Delivery. VI. Carbomer and Chitosan Improve the Intestinal Absorption of the Peptide Drug Buserelin In Vivo | Henrik. L. Lueßen, Bas. J. de Leeuw, Mariska W. E. Langemeÿer, A.(Bert) G. de Boer and J. Coos. Verhoef, et al. |
| 1673-1678 | Oral Absorption of D-Oligopeptides in Rats via the Paracellular Route | Yan-Ling He, Susan Murby, Larry Gifford, Andrew Collett and Geoff Warhurst, et al. |
| 1679-1685 | Proteolysis of Human Calcitonin in Excised Bovine Nasal Mucosa: Elucidation of the Metabolic Pathway by Liquid Secondary lonization Mass Spectrometry (LSIMS) and Matrix Assisted Laser Desorption lonization Mass Spectrometry (MALDI) | Steffen R. Lang, Werner Staudenmann, Peter James, Hans-Jörg Manz and Rudolf Kessler, et al. |
| 1686-1692 | Chitosans as Absorption Enhancers for Poorly Absorbable Drugs. 1: Influence of Molecular Weight and Degree of Acetylation on Drug Transport Across Human Intestinal Epithelial (Caco-2) Cells | Nicolaas G. M. Schipper, Kjell M. Vårum and Per Artursson |
| 1693-1698 | Improving Protein Delivery from Microparticles Using Blends of Poly(DL lactide co-glycolide) and Poly(ethylene oxide)-poly(propylene oxide) Copolymers | Ming-Kung Yeh, Stanley S. Davis and Allan G. A. Coombes |
| 1699-1703 | Pulmonary Targeting of Liposomal Triamcinolone Acetonide Phosphate | Ricardo J. Gonzalez-Rothi, Sandra Suarez, Guenther Hochhaus, Hans Schreier and Anatoly Lukyanov, et al. |
| 1704-1709 | Synergistic Effect Between Size and Cholesterol Content in the Enhanced Hepatic Uptake Clearance of Liposomes Through Complement Activation in Rats | H. Harashima, T. M. Huong, T. Ishida, Y. Manabe and H. Matsuo, et al. |
| 1710-1715 | In Vivo and In Vitro Percutaneous Absorption of Cancer Preventive Flavonoid Apigenin in Different Vehicles in Mouse Skin | Boyong Li and Diane F. Birt |
| 1716-1719 | Bioadhesion of Lectin-Latex Conjugates to Rat Intestinal Mucosa | Juan M. Irache, Carlo Durrer, Dominique Duchêne and Gilles Ponchel |
| 1720-1724 | Applications and Simulations of a Discontinuous Oral Absorption Pharmacokinetic Model | Jennifer Wright Witcher and F. Douglas Boudinot |
| 1725-1729 | The Influence of Water on Electrostatic Charge Retention and Dissipation in Pharmaceutical Compacts for Powder Coating | M. P. Grosvenor and J. N. Staniforth |
| 1730-1733 | The Effect of Temperature on the Surface Nature of an Adsorbed Layer of Poly(oxyethylene)-poly(oxypropylene)-poly(oxyethylene) Block Copolymers | David L Carthew, Graham Buckton, Gary E. Parsons and Stephen Poole |
| 1734-1738 | Development and Mechanical Characterization of Bioadhesive Semi-Solid, Polymeric Systems Containing Tetracycline for the Treatment of Periodontal Diseases | David S. Jones, A. David Woolfson, Jasmina Djokic and W. A. Coulter |
| 1739-1745 | A Comparison of Elastic Moduli Derived from Theory, Microindentation, and Ultrasonic Testing | Susan K. Lum and Wendy C. Duncan-Hewitt |
| 1746-1751 | Influence of Surface Free Energies and Cohesion Parameters on Pharmaceutical Material Interaction Parameters–Theoretical Simulations | Jérôme Barra, François Lescure and Eric Doelker |
| 1752-1754 | Effect of Charge on Oligopeptide Transporter-Mediated Permeation of Cyclic Dipeptides Across Caco-2 Cell Monolayers | Kiyoshi Tamura, Chao-Pin Lee, Philip L. Smith and Ronald T. Borchardtu |
| 1755-1758 | An Improved Intercept Method for the Assessment of Absorption Rate in Bioequivalence Studies | Panos Macheras, Mira Symillides and Christos Reppas |
| 1759 | Controlled Release Technologies: Current Status and Future Prospects | Richard Guy, Michael Powell, Joseph Fix and Kinam Park |
| 1760-1764 | Oral Controlled Release Technology for Peptides: Status and Future Prospects | Joseph A. Fix |
| 1765-1769 | Current Status and Future Prospects of Transdermal Drug Delivery | Richard H. Guy |
| 1770-1776 | Biocompatibility Issues of Implantable Drug Delivery Systems | Haesun Park and Kinam Park |
| 1777-1785 | Drug Delivery Issues in Vaccine Development | Michael R Powell |
| 1786-1794 | Characterization of Lipid Membrane Dynamics by Simulation: 3. Probing Molecular Transport Across the Phospholipid Bilayer | B. Jin and J. Hopfinger |
| 1795-1798 | Guidance in the Setting of Drug Particle Size Specifications to Minimize Variability in Absorption | Kevin C. Johnson and Archie C. Swindell |
| 1799-1803 | In-Vitro Dissolution Profile Comparison: Statistics and Analysis, Model Dependent Approach | Pradeep M. Sathe, Yi Tsong and Vinod P. Shah |
| 1804-1810 | Feasibility of Effect-Controlled Clinical Trials of Drugs with Pharmacodynamic Hysteresis Using Sparse Data | William E Ehling, Yoshiaki Matsumoto and Gerhard Levy |
| 1811-1814 | Characterization of a Solid State Reaction Product from a Lyophilized Formulation of a Cyclic Heptapeptide. A Novel Example of an Excipient-Induced Oxidation | David C. Dubost, Michael J. Kaufman, Jeffrey A. Zimmerman, Michael J. Bogusky and Arthur B. Coddington, et al. |
| 1815-1820 | Degradation Kinetics of BMP 777, an Elastase Inhibitor | Krishnaswamy S. Raghavan, David B. Gray, Thomas H. Scholz, Gregory A. Nemeth and Munir A. Hussain |
| 1821-1827 | Chemical and Swelling Evaluations of Amino Group Crosslinking in Gelatin and Modified Gelatin Matrices | Clyde M. Ofner, III and William A. Bubnis |
| 1828-1832 | Stereoselective and Carrier-Mediated Transport of Monocarboxylic Acids Across Caco-2 Cells | Takuo Ogihara, Ikumi Tamai, Hitomi Takanaga, Yoshimichi Sai and Akira Tsuji |
| 1833-1837 | Biliary Excretion of Glycyrrhizin in Rats: Kinetic Basis for Multiplicity in Bile Canalicular Transport of Organic Anions | Hisafumi Shimamura, Hiroshi Suzuki, Osamu Tagaya, Tohru Horie and Yuichi Sugiyama |
| 1838-1845 | Gastrointestinal Uptake of Biodegradable Microparticles: Effect of Particle Size | Manisha P. Desai, Vinod Labhasetwar, Gordon L. Amidon and Robert J. Levy |
| 1846-1850 | Liver Targeting of Interferon Through Pullulan Conjugation | Keli Xi, Yasuhiko Tabata, Kazuko Uno, Miwa Yoshimoto and Tsunataro Kishida, et al. |
| 1851-1855 | The pH-Dependence in the Partitioning Behaviour of (RS)-[3H]Propranolol Between MDCK Cell Lipid Vesicles and Buffer | Stefanie D. Krämer and Heidi Wunderli-Allenspach |
| 1856-1860 | New Cationic Lipid Formulations for Gene Transfer | Feng Liu, Jingping Yang, Leaf Huang and Dexi Liu |
| 1861-1864 | Riboflavin-Enhanced Transport of Serum Albumin Across the Distal Pulmonary Epithelium | O. Douglas Wangensteen, Marilyn M. Bartlett, Jonathan K. James, Zhen-fan Yang and Philip S. Low |
| 1865-1870 | Anionic Gels as Vehicles for Electrically-Modulated Drug Delivery. I. Solvent and Drug Transport Phenomena | Chang-Shan Hsu and Lawrence H. Block |
| 1871-1874 | A New Method for Diffusion Measurement in Polymeric Films Based on a Stacked Sheet Concept | Hans Sjöberg, Rolf Bergman and Lars-Olof Sundelöf |
| 1875-1880 | Deacetylation of Diltiazem by Several Rabbit Tissues | Lorenzo J. Fraile, José J. Aramayona, Miguel A. Bregante, María A. García and Ana R. Abadía |
| 1881-1886 | Localization of Purine Metabolizing Enzymes in Bovine Brain Microvessel Endothelial Cells: An Enzymatic Blood-Brain Barrier for Dideoxynucleosides? | Mark D. Johnson and Bradley D. Anderson |
| 1887-1891 | Different pH Dependency of Mitomycin C Activity in Monolayer and Three-Dimensional Cultures | Wan-Ching Yen, Thomas Schmittgen and Jessie L.-S. Au |
| 1892-1895 | Application of the Electrotopological State Index to QSAR Analysis of Flavone Derivatives as HIV-1 Integrase Inhibitors | John K. Buolamwini, Krishnamchari Raghavan, Mark R. Fesen, Yves Pommier and Kurt W. Kohn, et al. |
| 1896-1901 | A Candidate for Cancer Gene Therapy: MIP-lα Gene Transfer to an Adenocarcinoma Cell Line Reduced T\imorigenicity and Induced Protective Immunity in Immunocompetent Mice | Emi Nakashima, Akiko Oya, Yuri Kubota, Naomi Kanada and Ryo Matsushita, et al. |
| 1902-1904 | BOOK REVIEWS |
| 1905-1906 | Reviewers for Pharmaceutical Research November 1995 Through October 1996 |
| 1907-1910 | Author Index to Volume 13 (1996) |
| 1911-1915 | Subject Index to Volume 13 (1996) |
| 1 | News from the National Institute of General Medical Sciences (NIGMS) | Rochelle M. Long |
| 2-10 | Tumor Vascular Endothelium: Barrier or Target in Tumor Directed Drug Delivery and Immunotherapy | Grietje Molema, Lou F. M. H. de Leij and Dirk K. F. Meijer |
| 11-17 | Esterase-Sensitive Cyclic Prodrugs of Peptides: Evaluation of a Phenylpropionic Acid Promoiety in a Model Hexapeptide | Giovanni M. Pauletti, Sanjeev Gangwar, Binghe Wang and Ronald T. Borchardt |
| 18-24 | Influence of Fluorescent Labelling of Polystyrene Particles on Phagocytic Uptake, Surface Hydrophobicity, and Plasma Protein Adsorption | Rainer H. Müller, Dörte Rühl, Martin Lück and Bernd.-R. Paulke |
| 25-36 | Assembly and Dissociation of Human Insulin and LysB28ProB29-Insulin Hexamers: A Comparison Study | Duane T. Birnbaum, Maureen A. Kilcomons, Michael R. DeFelippis and John M. Beals |
| 37-41 | Tensioactivity and Supramolecular Organization of the Palmitoyl Prodrug of Timolol | Brigitte Pech, Jacques-Emile Proust, Yves Bouligand and Jean-Pierre Benoit |
| 42-49 | In Vitro Human Skin Barrier Modulation by Fatty Acids: Skin Permeation and Thermal Analysis Studies | Hanafi Tanojo, Joke A. Bouwstra, Hans E. Junginger and Harry E. Boddé |
| 50-55 | Selegiline Percutaneous Absorption in Various Species and Metabolism by Human Skin | Shashank Rohatagi, Jeffrey S. Barrett, Lee J. McDonald, Esther M. Morris and John Darnow, et al. |
| 56-62 | In Vivo Evaluation of Acyclovir Prodrug Penetration and Metabolism Through Rat Skin Using a Diffusion/Bioconversion Model | Hiroto Bando, Mikiko Sahashi, Fumiyoshi Yamashita, Yoshinobu Takakura and Mitsuru Hashida |
| 63-66 | Drug Reservoir Composition and Transport of Salmon Calcitonin in Transdermal Iontophoresis | Patrizia Santi, Paolo Colombo, Ruggero Bettini, Pier Luigi Catellani and Antonia Minutello, et al. |
| 67-72 | Extrahepatic Ischemia-Reperfusion Injury Reduces Hepatic Oxidative Drug Metabolism as Determined by Serial Antipyrine Clearance | Bill J. Gurley, Gary W. Barone, Kazuto Yamashita, Sabrena Polston and Mark Estes, et al. |
| 73-79 | Interaction Between Polyalkylcyanoacrylate Nanoparticles and Peritoneal Macrophages: MTT Metabolism, NET Reduction, and NO Production | Teresa Cruz, Rogério Gaspar, Ana Donato and Celeste Lopes |
| 80-85 | Intravenous Infusion of RMP-7 Increases Ocular Uptake of Ganciclovir | Peter J. Elliot, Raymond T. Bartus, Jasmina B. Mackic and Berislav V. Zlokovic |
| 86-90 | Renal Disposition of Recombinant Human Interleukin-11 in the Isolated Perfused Rat Kidney | Akira Takagi, Yoshiyuki Yabe, Yoshikazu Oka, Kenzo Sawai and Yoshinobu Takakura, et al. |
| 91-97 | Prospective Use of Population Pharmacokinetics/ Pharmacodynamics in the Development of Cisatracurium | Virginia D. Schmith, Jill Fiedler-Kelly, Luann Phillips and Thaddeus H. Grasela |
| 98-102 | Mirtazapine Pharmacokinetics with Two Dosage Regimens and Two Pharmaceutical Formulations | Cees J. Timmer, Jan E. Paanakker and Maria Vrijmoed-de Vries |
| 103-107 | The Use of Scintigraphy to Provide 'Proof of Concept' for Novel Polysaccharide Preparations Designed for Colonic Drug Delivery | Dawn A. Adkin, Carole J. Kenyon, E. Itzhack Lerner, Isaac Landau and Eric Strauss, et al. |
| 108-111 | Near-Infrared Spectroscopy as a Nondestructive Alternative to Conventional Tablet Hardness Testing | Karen M. Morisseau and Christopher T. Rhodes |
| 112-116 | Nebulization of NanoCrystals™: Production of a Respirable Solid-in-Liquid-in-Air Colloidal Dispersion | Timothy S. Wiedmann, Lan DeCastro and Ray W. Wood |
| 117-118 | Editorial |
| 119-127 | Applications of the Ion-Pair Concept to Hydrophilic Substances with Special Emphasis on Peptides | David Quintanar-Guerrero, Eric Allémann, Hatem Fessi and Erie Doelker |
| 128-134 | Drug Equilibration Across the Blood—Brain Barrier-Pharmacokinetic Considerations Based on the Microdialysis Method | Margareta Hammarlund-Udenaes, Lennart K. Paalzow and Elizabeth C. M. de Lange |
| 135-144 | The Pharmacists' Implementation of Pharmaceutical Care (PIPC) Model | Folakemi T. Odedina, Charles D. Hepler, Richard Segal and David Miller |
| 145-151 | The Association of Prescription Status, Patient Age, Patient Gender, and Patient Question Asking Behavior with the Content of Pharmacist−Patient Communication | Jon C. Schommer and Joseph B. Wiederholt |
| 152-155 | The Use of Human Hepatocytes to Select Compounds Based on Their Expected Hepatic Extraction Ratios in Humans | Th. Lavé, S. Dupin, C. Schmitt, B. Valles and G. Ubeaud, et al. |
| 156-163 | Using Computer Simulated Results of a Bulk Drug Substance Assay to Determine Acceptance Criteria for Method Validation | Richard D. Bunnell |
| 164-168 | Effect of Size and Charge on the Passive Diffusion of Peptides Across Caco-2 Cell Monolayers via the Paracellular Pathway | Giovanni M. Pauletti, Franklin W. Okumu and Ronald T. Borchardt |
| 169-175 | Effect of Restricted Conformational Flexibility on the Permeation of Model Hexapeptides Across Caco-2 Cell Monolayers | Franklin W. Okumu, Giovanni M. Pauletti, David G. Vander Velde, Teruna J. Siahaan and Ronald T. Borchardt |
| 176-180 | Use of the Intestinal Bile Acid Transporter for the Uptake of Cholic Acid Conjugates with HIV-1 Protease Inhibitory Activity | Matts Kågedahl, Peter W. Swaan, Carl T. Redemann, Mary Tang and Charles S. Craik, et al. |
| 181-185 | Development and in Vitro Evaluation of Systems to Protect Peptide Drugs from Aminopeptidase N | Andreas Bernkop-Schnürch and Michaela K. Marschütz |
| 186-189 | Activation of Signal Transduction Kinases by Tamoxifen | Jauh-Lin Duh, Rong Yu, Jie-Jun Jiao, George A. Matwyshyn and Wei Li, et al. |
| 190-196 | Self-Assembling DNA-Lipid Particles for Gene Transfer | Yuan-Peng Zhang, Dorothy L. Reimer, Guoyang Zhang, Patricia H. Lee and Marcel B. Bally |
| 197-202 | Binding of Prednisolone and Its Ester Prodrugs in the Skin | Tomohiro Hikima and Kakuji Tojo |
| 203-207 | Characterization of Pulmonary Alveolar Esterases of the Primate Cercopithecus pygerythrus | Henry M. J. Leng and James A. Syce |
| 208-212 | The Equivalent Bronchodilator Effects of Salbutamol Formulated in Chlorofluorocarbon and Hydrofluoroalkane-134a Metered Dose Inhalers on the Histamine-Induced Pulmonary Response in Dogs | Mari Nogami-Itoh, Ikuhisa Yakuo, David M. Hammerbeck, Richard L. Miller and Kunihiko Takeyama |
| 213-217 | Pharmacokinetics and Antiepileptic Activity of Valproyl Hydroxamic Acid Derivatives | Micha Levi, Boris Yagen and Meir Bialer |
| 218-223 | Formulation of a Charcoal Suspension for Intratumor Injection. Part 1: Study of the Nature, Granulometry, and Concentration | L. Bonhomme-Faivre, M. C. Mathieu, J. L. Grossiord, P. Depreatere and G. Couarraze, et al. |
| 224-229 | The Role of Liver and Kidney on the Pharmacokinetics of a Recombinant Amino Terminal Fragment of Bactericidal/Permeability-Increasing Protein in Rats | Robert J. Bauer, Kenneth Der, Nneka Ottah-Ihejeto, Jennifer Barrientos and Ada H. C. Kung |
| 230-237 | A Model with Separate Hepato-Portal Compartment ("First-Pass" Model): Fitting to Plasma Concentration-Time Profiles in Humans | Vladimir Piotrovskij and Achiel Van Peer |
| 238-240 | Gly-L-Phe Transport and Metabolism Across Primary Cultured Rabbit Tracheal Epithelial Cell Monolayers | Fumiyoshi Yamashita, Kwang-Jin Kim and Vincent H. L. Lee |
| 241-245 | Pharmacodynamic Evaluation of Mitomycin C Analog BMS-181174 for Potential use in Intravesical Bladder Cancer Therapy | Wan-Ching Yen and Jessie L.-S. Au |
| 246-250 | Effects of Peptide Structure on Transport Properties of Seven Thyrotropin Releasing Hormone (TRH) Analogues in a Human Intestinal Cell Line (Caco-2) | Ute Werner, Thomas Kissel and Werner Stüber |
| 251-253 | Bioavailability of Phenytoin and Anticonvulsant Activity after Oral Administration of Phenytoin-bis-hydroxyisobutyrate to Rats | Gerhard K. E. Scriba and Didier M. Lambert |
| 254-256 | BOOK REVIEWS |
| 258-259 | In Memoriam: Dr. Harry Boddé, Associate Professor, Division of Pharmaceutical Technology, Leiden/Amsterdam Center for Drug Research (LACDR), Leiden University, The Netherlands | D.D. Breimer |
| 259-266 | The Oral Absorption of Micro- and Nanoparticulates: Neither Exceptional Nor Unusual | Alexander T. Florence |
| 267-288 | Application of Microdialysis in Pharmacokinetic Studies | William F. Elmquist and Ronald J. Sawchuk |
| 289-293 | Glucose-Responsive Gel from Phenylborate Polymer and Poly (Vinyl Alcohol): Prompt Response at Physiological pH Through the Interaction of Borate with Amino Group in the Gel | Issei Hisamitsu, Kazunori Kataoka, Teruo Okano and Yasuhisa Sakurai |
| 294-298 | Near-Infrared (NIR) Monitoring of H2O2 Vapor Concentration During Vapor Hydrogen Peroxide (VHP) Sterilisation | S. Corveleyn, G. M. R. Vandenbossche and J. P. Remon |
| 299-302 | Theory and Computer Programs for Calculating Solution pH, Buffer Formula, and Buffer Capacity for Multiple Component System at a Given Ionic Strength and Temperature | Hirokazu Okamoto, Kiyoko Mori, Kumiko Ohtsuka, Hiroyuki Ohuchi and Hiroaki Ishii |
| 303-308 | Evaluation of the Proposed FDA Pilot Dose-Response Methodology for Topical Corticosteroid Bioequivalence Testing | Patrick H. Demana, Eric W. Smith, Roderick B. Walker, John M. Haigh and Isadore Kanfer |
| 309-315 | Nonlinear Mixed Effects Modeling of Single Dose and Multiple Dose Data for an Immediate Release (IR) and a Controlled Release (CR) Dosage Form of Alprazolam | Mohammad Hossain, Eugene Wright, Raman Baweja, Thomas Ludden and Raymond Miller |
| 316-319 | Depression, Cognitive Impairment, and Understanding of Medication Directions in Hospitalized Elderly Patients | Shelly L. Gray, Mark A. Sager, Mitchell R. Lestico and M. Jalaluddin |
| 320-324 | Carrier-Mediated Transport of Monocarboxylic Acids in Primary Cultured Epithelial Cells from Rabbit Oral Mucosa | Naoki Utoguchi, Yoshiteru Watanabe, Takahisa Suzuki, Junko Maehara and Yoshiaki Matsumoto, et al. |
| 325-328 | Delivery of Loperamide Across the Blood-Brain Barrier with Polysorbate 80-Coated Polybutylcyanoacrylate Nanoparticles | Renad N. Alyautdin, Valery E. Petrov, Klaus Langer, Achim Berthold and Dimitry A. Kharkevich, et al. |
| 329-336 | Pharmacokinetics and Pharmacodynamics of an Investigational Antipsychotic Agent, CI-1007, in Rats and Monkeys | Meihua Rose Feng, Ann E. Corbin, Yanfeng Wang, Curt L. Christoffersen and James N. Wiley, et al. |
| 337-344 | Physiologically Based Pharmacokinetic Models of 2′,3′-Dideoxyinosine | Hyo-Jeong K. Kang, M. Guillaume Wientjes and Jessie L.-S. Au |
| 345-350 | Extensive Biliary Excretion of the Model Opioid Peptide [D-PEN2,5] Enkephalin in Rats | Cuiping Chen and Gary M. Pollack |
| 351-353 | Covalent Binding of a Bucillamine Derivative with Albumin in Sera from Healthy Subjects and Patients with Various Diseases | Ryuichi Narazaki and Masaki Otagiri |
| 354-357 | The AERX™ Aerosol Delivery System | Jeff Schuster, Reid Rubsamen, Peter Lloyd and Jack Lloyd |
| 358-361 | Antifungal Activity of a New Triterpenoid Glycoside from Pithecellobium racemosum (M.) | Ikhlas A. Khan, Alice M. Clark and James D. McChesney |
| 362-365 | Development of a Novel Bioactive Formulation of Vasoactive Intestinal Peptide in Sterically Stabilized Liposomes | Florence Séjourné, Israel Rubinstein, Hideyuki Suzuki and Hayat Alkan-Önyüksel |
| 366-370 | Mechanistic Investigation of the Reduction in Antimicrobial Activity of Ciprofloxacin by Metal Cations | Henry H. M. Ma, Francis C. K. Chiu and Ronald C. Li |
| 371 | News from the National Institute of General Medical Sciences (NIGMS) | Rochelle M. Long |
| 372-387 | Capillary Electrophoresis in Pharmaceutical Analysis | Lisa A. Holland, Nik P. Chetwyn, Melissa D. Perkins and Susan M. Lunte |
| 388-400 | Sequence Alignments of the H+-Dependent Oligopeptide Transporter Family PTR: Inferences on Structure and Function of the Intestinal PET1 Transporter | Richard C. Graul and Wolfgang Sadée |
| 401-405 | Guanidine Transport in a Human Choriocarcinoma Cell Line (JAR) | Shoshana Zevin, Marci E. Schaner, Nicholas P. Illsley and Kathleen M. Giacomini |
| 406-409 | Taurine Transport in Cultured Choroid Plexus | Vikram K. Ramanathan, Suk-Jae Chung, Kathleen M. Giacomini and Claire M. Brett |
| 410-414 | Molecular Mobility of Supercooled Amorphous Indomethacin, Determined by Dynamic Mechanical Analysis | Vlassios Andronis and George Zografi |
| 415-419 | Effect of Compaction Temperature on Consolidation of Amorphous Copolymers with Different Glass Transition Temperatures | K. Van der Voort Maarschalk, K. Zuurman, M. J. Van Steenbergen, W. E. Hennink and H. Vromans, et al. |
| 420-425 | The Stability of Recombinant Human Growth Hormone in Poly(lactic-co-glycolic acid) (PLGA) Microspheres | Jeffrey L. Cleland, Anne Mac, Brooks Boyd, Janet Yang and Eileen T. Duenas, et al. |
| 426-430 | Effect of Temperature History on the Freeze-Thawing Process and Activity of LDH Formulations | Maggie Aldén and Anna Magnusson |
| 431-437 | Spray Dried Powders and Powder Blends of Recombinant Human Deoxyribonuclease (rhDNase) for Aerosol Delivery | Hak-Kim Chan, Andy Clark, Igor Gonda, Marco Mumenthaler and Chung Hsu |
| 438-443 | Influence of Metering Chamber Volume and Water Level on the Emitted Dose of a Suspension-Based pMDI Containing Propellant 134a | Robert O. Williams, Jie Liu and John J. Koleng |
| 444-449 | Effect of Sodium Bicarbonate Amount on In Vitro Indomethacin Release from Self-Setting Carbonated-Apatite Cement | Makoto Otsuka, Yoshihisa Matsuda, Zeren Wang, Jeffrey L. Fox and William I. Higuchi |
| 450-457 | Textural Analysis and Flow Rheometry of Novel, Bioadhesive Antimicrobial Oral Gels | David S. Jones, A. David Woolfson and Andrew F. Brown |
| 458-462 | Cytotoxicity of Solid Lipid Nanoparticles as a Function of the Lipid Matrix and the Surfactant | Rainer H. Müller, Dörte Rühl, Stephan Runge, Kai Schulze-Forster and Wolfgang Mehnert |
| 463-468 | Splenic Trapping of Nanoparticles: Complementary Approaches for In Situ Studies | Marina Demoy, Stéphane Gibaud, Jean Paul Andreux, Colette Weingarten and Bruno Gouritin, et al. |
| 469-474 | Development of a Statistical Model for the Formation of Poly [Acryloyl Hydroxyethyl Starch] Microspheres | L. K. Huang, R. C. Mehta and P. P. DeLuca |
| 475-482 | Evaluation of a Statistical Model for the Formation of Poly [Acryloyl Hydroxyethyl Starch] Microspheres | L. K. Huang, R. C. Mehta and P. P. DeLuca |
| 483-485 | Non-Polarized Secretion of Mouse Interferon-β from Gene-Transferred Human Intestinal Caco-2 Cells | Kenji Kawabata, Mayumi Kondo, Yoshihiko Watanabe, Yoshinobu Takakura and Mitsuru Hashida |
| 486-491 | Analysis of Drug Permeation Across Caco-2 Monolayer: Implication for Predicting In Vivo Drug Absorption | Shinji Yamashita, Yoshihiro Tanaka, Yoriko Endoh, Yoko Taki and Toshiyasu Sakane, et al. |
| 492-496 | Transport, Uptake, and Metabolism of the Bis(pivaloyloxymethyl)-Ester Prodrug of 9-(2- Phosphonylmethoxyethyl)Adenine in an In Vitro Cell Culture System of the Intestinal Mucosa (Caco-2) | Pieter Annaert, Renaat Kinget, Lieve Naesens, Erik de Clercq and Patrick Augustijns |
| 497-502 | Characterization of Fluids from the Stomach and Proximal Jejunum in Men and Women | Anders Lindahl, Anna-Lena Ungell, Lars Knutson and Hans Lennernäs |
| 503-507 | The Effect of Intestinal Bacteria Adherence on Drug Diffusion Through Solid Films Under Stationary Conditions | Abraham Rubinstein, Raphael Radai, Michael Friedman, Paula Fischer and J. Stefan Rokem |
| 508-511 | Evaluation of Renal Tubular Secretion and Reabsorption of Levofloxacin in Rats | Ikuko Yano, Tatsuya Ito, Mikihisa Takano and Ken-ichi Inui |
| 512-515 | The Effect of RPR 102341 on Theophylline Metabolism and Phenacetin O-Deethylase Activity in Human Liver Microsomes | Rebecca B. White, Heleen Heyn and Jeffrey C. Stevens |
| 516-521 | Hepatic Distribution and Clearance of Antisense Oligonucleotides in the Isolated Perfused Rat Liver | Arno Nolting, Robert K. DeLong, Michael H. Fisher, Eric Wickstrom and Gary M. Pollack, et al. |
| 522-526 | Interactions of Aldosterone Antagonist Diuretics with Human Serum Proteins | Norito Takamura, Toru Maruyama, Shamim Ahmed, Ayaka Suenaga and Masaki Otagiri |
| 527-532 | pH Dependent Binding of Ligands to Serum Lipoproteins | Nicolas Simon, Eric Dailly, Pascale Jolliet, Jean-Paul Tillement and Saïk Urien |
| 533-536 | Synthesis and β-Adrenergic Activities of R-Fluoronaphthyloxypropanolamine | Adeboye Adejare and Sophie S. Sciberras |
| 537-540 | Magnetically-Responsive Polymerized Liposomes as Potential Oral Delivery Vehicles | Hongming Chen and Robert Langer |
| 541-545 | Effect of Absorption Enhancers on Ciliated Epithelium: A Novel In Vivo Toxicity Screening Method Using Rotifers | Els Adriaens, Jody Voorspoels, Johan Mertens and Jean Paul Remon |
| 546-549 | Comparative Pharmacokinetics and Pharmacodynamics of Two Recomhinant Human Interferon Beta-la (IFNβ-la) Products Administered Intramuscularly in Healthy Male and Female Volunteers | John Alam, Susan Goelz, Patrice Rioux, James Scaramucci and Wendy Jones, et al. |
| 550-552 | BOOK REVIEWS |
| 553 | News From the National Institute of General Medical Sciences (NIGMS) | Rochelle M. Long |
| 554-555 | Are Graduate Programs Training Pharmaceutical Scientists to Function Effectively in the New, Highly Integrated and Globalized Pharmaceutical Industry? | Ronald T. Borchardt |
| 556-567 | Cyclodextrins: Their Future in Drug Formulation and Delivery | Valentine J. Stella and Roger A. Rajewski |
| 568-571 | Polar Molecular Surface Properties Predict the Intestinal Absorption of Drugs in Humans | Katrin Palm, Patric Stenberg, Kristina Luthman and Per Artursson1 |
| 572-577 | Intestinal Absorption Screening of Mixtures from Combinatorial Libraries in the Caco-2 Model | Eric W. Taylor, Jacqueline A. Gibbons and Rene A. Braeckman |
| 578-590 | Thermophysical Properties of Trehalose and Its Concentrated Aqueous Solutions | Danforth P. Miller, Juan J. de Pablo and Horacio Corti |
| 591-595 | Effect of Glass Transition Temperature on the Stability of Lyophilized Formulations Containing a Chimeric Therapeutic Monoclonal Antibody | Sarma P. Duddu and Paul R. Dal Monte |
| 596-600 | The Relationship Between Protein Aggregation and Molecular Mobility Below the Glass Transition Temperature of Lyophilized Formulations Containing a Monoclonal Antibody | Sarma P. Duddu, Guangzhong Zhang and Paul R. Dal Monte |
| 601-605 | Differential Molar Heat Capacities to Test Ideal Solubility Estimations | Steven H. Neau, Satej V. Bhandarkar and Eckhard W. Hellmuth |
| 606-612 | Solvent Effects on the Solubility and Physical Stability of Human Insulin-Like Growth Factor I | Jonas Fransson, Dan Hallén and Ebba Florin-Robertsson |
| 613-618 | Enhanced Oral Uptake of Tomato Lectin-Conjugated Nanoparticles in the Rat | Nasir Hussain, Praful U. Jani and Alexander T. Florence |
| 619-624 | N-Acyl-(α,γ Diaminobutyric Acid)n Hydrazide as an Efficient Gene Transfer Vector in Mammalian Cells in Culture | Jean-Yves Legendre, Arnold Trzeciak, Daniel Bur, Ulrich Deuschle and Andreas Supersaxo |
| 625-630 | Inhibition of Growth of Dictyostelium discoideum Amoebae by Bisphosphonate Drugs Is Dependent on Cellular Uptake | Michael J. Rogers, Xiaojuan Xiong, Xiaohui Ji, Jukka Mönkkönen and R. Graham G. Russell, et al. |
| 631-637 | Confocal Laser Scanning Microscopic Visualization of the Transport of Dextrans After Nasal Administration to Rats: Effects of Absorption Enhancers | Emmeline Marttin, J. Coos Verhoef, Christopher Cullander, Stefan G. Romeijn and J. Fred Nagelkerke, et al. |
| 638-644 | Macromolecules as Novel Transdermal Transport Enhancers for Skin Electroporation | Rita Vanbever, Mark R. Prausnitz and Véronique Préat |
| 645-649 | Restricted Intestinal Absorption of Some β-Lactam Antibiotics by an Energy-Dependent Efflux System in Rat Intestine | Hiroshi Saitoh, Hiroko Fujisaki, Bruce J. Aungst and Katsumi Miyazaki |
| 650-656 | Blood-to-Brain Transfer of Various Oxicams: Effects of Plasma Binding on Their Brain Delivery | Pascale Jolliet, Nicolas Simon, Francoise Brée, Saïk Urien and Alessandra Pagliara, et al. |
| 657-661 | Preparation of Biodegradable, Surface Engineered PLGA Nanospheres with Enhanced Lymphatic Drainage and Lymph Node Uptake | Ann E. Hawley, Lisbeth Illum and Stanley S. Davis |
| 662-666 | cDNA Cloning of the Mouse Bilirubin/Phenol Family of UDP-Glucuronosyltransferase (mUGTbr2-like) | Qian Chu, Wei Lei, Krishnamurthy Gudehithlu, George A. Matwyshyn and Maurizio Bocchetta, et al. |
| 667-671 | Jejunal Permeability: A Comparison Between the Ussing Chamber Technique and the Single-Pass Perfusion in Humans | H. Lennernäs, S. Nylander and A.-L. Ungell |
| 672-675 | Effect of a Chemical Delivery System for Dexamethasone (Dex-CDS) on Peritumoral Edema in an Experimental Brain Tumor Model | Tali Siegal, Ferenc Soti, Anat Biegon, Emil Pop and Marcus E. Brewster |
| 676-680 | Isolation and Characterization of Major Phase I and II Metabolites of Ibuprofen | Dorte R. Kepp, Ulla G. Sidelmann and Steen H. Hansen |
| 681-685 | The Enhancer Effect of Several Phenyl Alcohols on Percutaneous Penetration of 5-Fluorouracil | A. López, M. A. Pellett, F. Llinares, O. Díez-Sales and M. Herráez, et al. |
| 687-697 | Electrically-Assisted Transdermal Drug Delivery | Jim E. Riviere and Mark C. Heit |
| 698-705 | Aerosol Electrostatics I: Properties of Fine Powders Before and After Aerosolization by Dry Powder Inhalers | Peter R. Byron, Joanne Peart and John N. Staniforth |
| 706-712 | Cellular Delivery of Nucleoside Diphosphates: A Prodrug Approach | Shin Hong Kang, Achintya K. Sinhababu, Joseph G. Cory, Beverly S. Mitchell and Dhiren R. Thakker, et al. |
| 713-719 | Dynorphin Peptides: Antagonists of Melanocortin Receptors | J. Mark Quillan and Wolfgang Sadée |
| 720-724 | Basic Studies for the Practical Use of Bitterness Inhibitors: Selective Inhibition of Bitterness by Phospholipids | Yoshihisa Katsuragi, Yuki Mitsui, Tomoshige Umeda, Kazuya Otsuji and Susumu Yamasawa, et al. |
| 725-729 | The Effect of Benzyl Alcohol on Recombinant Human Interferon-γ | Xanthe M. Lam, Thomas W. Patapoff and Tue H. Nguyen |
| 730-735 | The Stabilization and Encapsulation of Human Growth Hormone into Biodegradable Microspheres | OluFunmi L. Johnson, Warren Jaworowicz, Jeffrey L. Cleland, Leonie Bailey and Margarita Charnis, et al. |
| 736-741 | Dependence of the Molecular Mobility and Protein Stability of Freeze-Dried γ-Globulin Formulations on the Molecular Weight of Dextran | Sumie Yoshioka, Yukio Aso and Shigeo Kojima |
| 742-749 | In Vivo Gene Transfer by Intravenous Administration of Stable Cationic Lipid/DNA Complex | Hans E. J. Hofland, Dea Nagy, Jing-Jie Liu, Kaye Spratt and Ya-Li Lee, et al. |
| 750-756 | The Use of Sonication for the Efficient Delivery of Plasmid DNA into Cells | Julie Ann Wyber, Julie Andrews and Antony D'Emanuele |
| 757-762 | Evidence for Diminished Functional Expression of Intestinal Transporters in Caco-2 Cell Monolayers at High Passages | Hongshi Yu, Thomas J. Cook and Patrick J. Sinko |
| 763-766 | In Vitro Permeability Across Caco-2 Cells (Colonic) Can Predict In Vivo (Small Intestinal) Absorption in Man—Fact or Myth | Shiyin Yee |
| 767-773 | Influence of Morphometric Factors on Quantitation of Paracellular Permeability of Intestinal Epithelia In Vitro | Andrew Collett, David Walker, Erika Sims, Yan-Ling He and Peter Speers, et al. |
| 774-779 | Membrane Transport in Hepatic Clearance of Drugs I: Extended Hepatic Clearance Models Incorporating Concentration-Dependent Transport and Elimination Processes | Younggil Kwon and Marilyn E. Morris |
| 780-785 | Membrane Transport in Hepatic Clearance of Drugs II: Zonal Distribution Patterns of Concentration-Dependent Transport and Elimination Processes | Younggil Kwon and Marilyn E. Morris |
| 786-792 | Role of Brain Tissue Localized Purine Metabolizing Enzymes in the Central Nervous System Delivery of Anti-HIV Agents 2′-β-Fluoro-2,3′-Dideoxyinosine and 2′-β-Fluoro-2′,3′-Dideoxyadenosine in Rats | Dharmendra Singhal, Michael E. Morgan and Bradley D. Anderson |
| 793-797 | Prednicarbate Biotransformation in Human Foreskin Keratinocytes and Fibroblasts | Anja Gysler, Katharina Lange, Hans Christian Korting and Monika Schäfer-Korting |
| 798-803 | Evaluation of Amorphous Ursodeoxycholic Acid by Thermal Methods | Etsuo Yonemochi, Yasuhiko Ueno, Takao Ohmae, Toshio Oguchi and Shin-ichiro Nakajima, et al. |
| 804-809 | The Crystallite-Gel-Model for Microcrystalline Cellulose in Wet-Granulation, Extrusion, and Spheronization | Peter Kleinebudde |
| 810-814 | Radiation Sterilization of Formoterol | J. P. Basly, I. Longy and M. Bernard |
| 815-819 | Development of a Novel Controlled-Release System for Gastric Retention | Arati A. Deshpande, Navnit H. Shah, Christopher T. Rhodes and Waseem Malick |
| 820-826 | In Vitro/In Vivo Comparison of Drug Release and Polymer Erosion from Biodegradable P(FAD-SA) Polyanhydrides—A Noninvasive Approach by the Combined Use of Electron Paramagnetic Resonance Spectroscopy and Nuclear Magnetic Resonance Imaging | Karsten Mäder, Yannick Crémmilleux, Abraham J. Domb, Jeffrey R Dunn and Harold M. Swartz |
| 827-832 | Free Fatty Acids Cause pH-Dependent Changes in Drug-Lipid Membrane Interactions Around Physiological pH | Stefanie D. Krämer, Christina Jakits-Deiser and Heidi Wunderli-Allenspach |
| 833-836 | Isolation and Characterization of an Acetylated Impurity in Escherichia coli-Derived Recombinant Human Interleukin-10 (IL-10) Drug Substance | Mollie N. Pflumm, Stephen C. Gruber, Anthony Tsarbopoulos, David Wylie and Birendra Pramanik, et al. |
| 837-839 | Graduate Education in the Pharmaceutical Sciences: How Can It Better Meet the Needs of the Generic Pharmaceutical Industry? | Alice E. Till |
| 839 | News from the National Institute of General Medical Sciences (NIGMS) | Rochelle M. Long |
| 840-841 | Tissue Engineering: A New Field and Its Challenges | Robert Langer |
| 842-847 | Gastrointestinal Drug Absorption: Is It Time to Consider Heterogeneity as Well as Homogeneity? | Panos Macheras and Panos Argyrakis |
| 848-852 | Scale-up of Adhesive Transdermal Drug Delivery Systems | Glenn A. Van Buskirk, Mario A. González, Vinod P. Shah, Scott Barnhardt and Colin Barrett, et al. |
| 853-859 | Cationic Lipid-Based Gene Delivery Systems: Pharmaceutical Perspectives | Ram I. Mahato, Alain Rolland and Eric Tomlinson |
| 860-864 | Modeling in Frequency Domain Used for Assessment of In Vivo Dissolution Profile | Mária Ďurišová and Ladislav Dedík |
| 865-872 | Microdialysis Studies of the Distribution of Stavudine into the Central Nervous System in the Freely-Moving Rat | Zheng Yang, Richard C. Brundage, Rashmi H. Barbhaiya and Ronald J. Sawchuk |
| 873-878 | The Disposition of Valproyl Glycinamide and Valproyl Glycine in Rats | Simcha Blotnik, Felix Bergman and Meir Bialer |
| 879-886 | Tyramine-Containing Poly(4-Nitrophenylacrylate) as lodinatable Ligand Carrier in Biodistribution Analysis | Shuji Kojima, Sabine André, Elena Y. Korchagina, Nicolai V. Bovin and Hans-Joachim Gabius |
| 887-891 | Improved Activity of a New Angiotensin Receptor Antagonist by an Injectable Spray-Dried Polymer Microsphere Preparation | François-Xavier Lacasse, Patrice Hildgen, Jacqueline Pérodin, Emmanuel Escher and Nigel C. Phillips, et al. |
| 892-898 | Development of a Freeze-Dried Albumin-Free Formulation of Recombinant Factor VIII SQ | Thomas Österberg, Angelica Fatouros and Marianne Mikaelsson |
| 899-904 | A Kinetic Study on Crystallization of an Amorphous Lubricant | Vesa-Pekka Lehto and Ensio Laine |
| 905-910 | Determination of Plasma Protein Adsorption on Magnetic Iron Oxides: Sample Preparation | Kai Thode, Martin Lück, Wolfhard Semmler, Rainer H. Müller and Mayk Kresse |
| 911-916 | Assessment of Dose Proportionality, Absolute Bioavailability, and Immunogenicity Response of CTLA4Ig (BMS-188667), a Novel Immunosuppressive Agent, Following Subcutaneous and Intravenous Administration to Rats | Nuggehally R. Srinivas, Wen Chyi Shyu, Russell S. Weiner, Garvin Warner and Charles Comereski, et al. |
| 917-922 | Novel Bioadhesive Chitosan-EDTA Conjugate Protects Leucine Enkephalin from Degradation by Aminopeptidase N | Andreas Bernkop-Schnürch, Christina Paikl and Claudia Valenta |
| 923-929 | Chitosans as Absorption Enhancers for Poorly Absorbable Drugs 2: Mechanism of Absorption Enhancement | Nicolaas G. M. Schipper, Susanne Olsson, Janet A. Hoogstraate, Albertus G. deBoer and Kjell M. Vårum, et al. |
| 930-935 | Mechanism of Absorption Enhancement in Humans After Rectal Administration of Ampicillin in Suppositories Containing Sodium Caprate | Tuulikki Lindmark, Johan D Söderholm, Gunnar Olaison, Gunnar Alván and Göran Ocklind, et al. |
| 936-941 | Characterization of Guanidine Transport in Human Renal Brush Border Membranes | Joanne K. Chun, Lei Zhang, Micheline Piquette-Miller, Ernest Lau and Li-Qin Tong, et al. |
| 942-945 | A Novel In Vitro Electrophysiological Bioassay for Transport of Loperamide Across Intestinal Epithelia | David Brayden, Derek Moriarty and Alan Baird |
| 946-948 | Direct Determination of Drug Content in Semisolid Formulations Using Step-Scan FT-IR Photoacoustic Spectroscopy | R. Neubert, B. Collin and S. Wartewig |
| 949-952 | Application of Moment Analysis to the Sigmoid Effect Model for Drug Administered Intravenously | Wojciech Krzyzanski and William J. Jusko |
| 953-955 | BOOK REVIEWS |
| 957 | Valuable Data + Competent Presentation = Good Science | Bernard Testa |
| 958-966 | Value of Pharmaceutical Sciences | Ronald T. Borchardt |
| 967-968 | Cmax/AUC, A Commentary | Thomas N. Tozer and Walter W. Hauck |
| 969-975 | Rational Design of Stable Lyophilized Protein Formulations: Some Practical Advice | John F. Carpenter, Michael J. Pikal, Byeong S. Chang and Theodore W. Randolph |
| 976-983 | Cooperation in Pharmacy-Drug Wholesaler Relations | William R. Doucette and Joseph B. Wiederholt |
| 984-991 | Discrimination Between Rival Dosing Histories | E. Niclas Jonsson, Janet R. Wade, Gun Almqvist and Mats O. Karlsson |
| 992-998 | Liposome-Mediated Therapy of Intracranial Brain Tumors in a Rat Model | Uma S. Sharma, Amarnath Sharma, Robert I. Chau and Robert M. Straubinger |
| 999-1003 | Pharmacokinetic Analysis of Benzodiazepine Receptor Binding of [123I]Iomazenil in Human Brain | Kiyomi Ito, Toshimitsu Momose, Hajime Kotaki, Yoshiki Kojima and Koujirou Yamamoto, et al. |
| 1004-1007 | Metabolism of Azetirelin, a New Thyrotropin-releasing Hormone (TRH) Analogue, by Intestinal Microorganisms | Isao Sasaki, Takashi Tamura, Tomoko Shibakawa, Takuya Fujita and Masahiro Murakami, et al. |
| 1008-1013 | Hepatic Extraction of Hexarelin, a New Peptidic GH Secretagogue, in the Isolated Perfused Rat Liver | Marie Roumi, Sylvie Marleau, Muny Boghen, Magnus Nilsson and Patrick Du Souich, et al. |
| 1014-1018 | Comparison of the Disposition of Hepatically-Generated Morphine-3-glucuronide and Morphine-6-glucuronide in Isolated Perfused Liver from the Guinea Pig | Robert W. Milne, Rikke Holm Jensen, Claus Larsen, Allan M. Evans and Roger L. Nation |
| 1019-1025 | Comparison of CYP3A Activities in a Subclone of Caco-2 Cells (TC7) and Human Intestine | Shamsi D. Raeissi, Zuyu Guo, Glenn L. Dobson, Per Artursson and Ismael J. Hidalgo |
| 1026-1029 | Prodrug and Analog Approaches to Improving the Intestinal Absorption of a Cyclic Peptide, GPIIb/IIIa Receptor Antagonist | Hiroshi Saitoh and Bruce J. Aungst |
| 1030-1038 | Mechanisms of Food Effects of Structurally Related Antiarrhythmic Drugs, Disopyramide and Bidisomide in the Rat | Kyu-Hyun Lee, Guang-Xin Xu, Grant L. Schoenhard and Chyung S. Cook |
| 1039-1045 | Consolidation Mechanisms of Pharmaceutical Solids: A Multi-Compression Cycle Approach | Davar Khossravi and William T. Morehead |
| 1046-1050 | Determination of Extent of Formaldehyde-Induced Crosslinking in Hard Gelatin Capsules by Near-Infrared Spectrophotometry | Thomas B. Gold, Robert G. Buice, Robert A. Lodder and George A. Digenis |
| 1051-1057 | Circulatory Concentrations of Fibrinolytic Species During Thrombolytic Therapy Estimated by Stirred-Tank Reactor Analysis | Vinod V. Tbliani and Edgar A. O'Rear |
| 1058-1065 | Effect of Vehicles and Penetration Enhancers on the In Vitro and In Vivo Percutaneous Absorption of Methotrexate and Edatrexate Through Hairless Mouse Skin | Dhruba J. Chatterjee, Wen Y. Li and Robert T. Koda |
| 1066-1072 | Simultaneous In Vivo Visualization and Localization of Solid Oral Dosage Forms in the Rat Gastrointestinal Tract by Magnetic Resonance Imaging (MRI) | Vera Christmann, Jörg Rosenberg, Jürgen Seega and Claus-Michael Lehr |
| 1073-1078 | Spreading and Retention of Vaginal Formulations in Post-Menopausal Women as Assessed by Gamma Scintigraphy | J. Brown, G. Hooper, C. J. Kenyon, S. Haines and J. Burt, et al. |
| 1079-1084 | Studies on the Mechanism of Absorption of Depot Neuroleptics: Fluphenazine Decanoate in Sesame oil | Jiang-Ping Luo, John W. Hubbard and Kamal K. Midha |
| 1085-1091 | Carboxyl-directed Pegylation of Brain-derived Neurotrophic Factor Markedly Reduces Systemic Clearance with Minimal Loss of Biologic Activity | Toshiyasu Sakane and William M. Pardridge |
| 1092-1098 | Evaluation of Genetic Stability of Recombinant Human Factor VIII by Peptide Mapping and On-line Mass Spectrometric Analysis | Marc J. Besman and Donald Shiba |
| 1099-1102 | Cocaine Pharmacokinetics/ Pharmacodynamics in Awake Freely Moving Rats | Mohsen A. Hedaya and Wei-Jian Pan |
| 1103 | News from the National Institute of General Medical Sciences (NIGMS) | Rochelle M. Long |
| 1104-1105 | The Future of Combinatorial Chemistry as a Drug Discovery Paradigm | Steven E. Hall |
| 1106-1114 | Flow Cytometry Applications in Pharmacodynamics and Drug Delivery | Murali Ramanathan |
| 1115-1121 | Sex Hormones Differentially Regulate Isoforms of UDP-Glucuronosyltransferase | Simone I. Strasser, Sheree A. Smid, Maurice L. Mashford and Paul V. Desmond |
| 1122-1126 | A Population Growth Model of Dissolution | Aristides Dokoumetzidis and Panos Macheras |
| 1127-1132 | Human Intestinal Permeability of Piroxicam, Propranolol, Phenylalanine, and PEG 400 Determined by Jejunal Perfusion | Narushi Takamatsu, Lynda S. Welage, Nasir M. Idkaidek, Dong-Yue Liu and Peter I-Der Lee, et al. |
| 1133-1139 | Pharmacokinetic Model of Ascorbic Acid in Healthy Male Volunteers During Depletion and Repletion | James F. Graumlich, Thomas M. Ludden, Cathy Conry-Cantilena, Louis R. Cantilena and Yaohui Wang, et al. |
| 1140-1145 | Application of Pharmacodynamic Modeling for Designing Time-Variant Dosing Regimens to Overcome Nitroglycerin Tolerance in Experimental Heart Failure | John Anthony Bauer, Joseph P. Balthasar and Ho-Leung Fung |
| 1146-1150 | Utilization of an Amorphous Form of a Water-Soluble GPIIb/IIIa Antagonist for Controlled Release from Biodegradable Microspheres | Shigeyuki Takada, Tomofumi Kurokawda, Keiko Miyazaki, Susumu Iwasa and Yasuaki Ogawa |
| 1151-1160 | Effect of Freezing Rate on the Stability of Liposomes During Freeze-Drying and Rehydration | Ewoud C. A. van Winden, Wei Zhang and Daan J. A. Crommelin |
| 1161-1170 | Theory of Force Transducer Design Optimization for Die Wall Stress Measurement During Tablet Compaction: Optimization and Validation of Split-Web Die Using Finite Element Analysis | Chuntien Yeh, Syed A. Altaf and Stephen W. Hoag |
| 1171-1175 | Study of Hygroscopic Properties of Aqueous Mixtures of Disodium Fluorescein and Sodium Chloride Using an Electrodynamic Balance | Chak K. Chan, Chin S. Kwok and Albert H. L. Chow |
| 1176-1180 | Simultaneous Quantification of an Enantiomer and the Racemic Compound of Ibuprofen by X-ray Powder Diffractometry | Neelima V. Phadnis and Raj Suryanarayanan |
| 1181-1185 | Effect of Ionic Strength on Solution Stability of PNU-67590A, A Micellar Prodrug of Methylprednisolone | Hirokazu Okamoto, Kiyoko Mori, Kumiko Ohtsuka, Hiroyuki Ohuchi and Hiroaki Ishii |
| 1186-1191 | ESR Dosimetry of Irradiated Ascorbic Acid | J.P. Basly, I. Longy and M. Bernard |
| 1192-1196 | Radiation Effects on Dopamine and Norepinephrine | J. P. Basly, I. Longy and M. Bernard |
| 1197-1202 | N-Trimethyl Chitosan Chloride as a Potential Absorption Enhancer Across Mucosal Surfaces: In Vitro Evaluation in Intestinal Epithelial Cells (Caco-2) | Awie R Kotzé, Henrik L. Lueβen, Bas J. de Leeuw, (A)Bert G. de Boer and J. Coos Verhoef, et al. |
| 1203-1209 | Cellular Retention of Liposome-Delivered Anionic Compounds Modulated by a Probenecid-Sensitive Anion Transporter | Yu-Kyoung Oh and Robert M. Straubinger |
| 1210-1215 | Estimation of the Relative Contribution of the Transcellular and Paracellular Pathway to the Transport of Passively Absorbed Drugs in the Caco-2 Cell Culture Model | Vaishali Pade and Salomon Stavchansky |
| 1216-1222 | The Absence of Accessible Vitronectin Receptors in Differentiated Tissue Hinders Adenoviral-Mediated Gene Transfer to the Intestinal Epithelium In Vitro | Elke Walter, Maria A. Croyle, Blake J. Roessler and Gordon L. Amidon |
| 1223-1227 | Enhanced Anti-Inflammatory Effects of Cu, Zn-Superoxide Dismutase Delivered by Genetically Modified Skin Fibroblasts In Vitro and In Vivo | Katsuhiko Okumura, Kohshi Nishiguchi, Yusuke Tanigawara, Sachiko Mori and Seigo Iwakawa, et al. |
| 1228-1235 | Kinetic Analysis of Transcytosis of Epidermal Growth Factor in Madin-Darby Canine Kidney Epithelial Cells | Akiko Kozu, Yukio Kato, Yoshihisa Shitara, Manabu Hanano and Yuichi Sugiyama |
| 1236-1240 | Kinetic Analysis of Tetraethylammonium Transport in the Kidney Epithelial Cell Line, LLC-PK1 | Yoshiko Tomita, Yuko Otsuki, Yukiya Hashimoto and Ken-ichi Inui |
| 1241-1245 | Perfusion Cells for Studying Regional Variation in Oral-Mucosal Permeability in Humans. I: Kinetic Aspects in Oral-Mucosal Absorption of Alkylparabens | Yuji Kurosaki, Koji Vano and Toshikiro Kimura |
| 1246-1251 | Polar Solute Transport Across the Pigmented Rabbit Conjunctiva: Size Dependence and the Influence of 8-Bromo Cyclic Adenosine Monophosphate | Yoshihide Horibe, Ken-ichi Hosoya, Kwang-Jin Kim, Taro Ogiso and Vincent H. L. Lee |
| 1252-1257 | The Effect of Current on Skin Barrier Function In Vivo: Recovery Kinetics Post-Iontophoresis | Norris G. Turner, Yogeshvar N. Kalia and Richard H. Guy |
| 1258-1263 | lontophoretic Delivery Across the Skin: Electroosmosis and Its Modulation by Drug Substances | Jouni Hirvonen and Richard H. Guy |
| 1264-1268 | Biphasic Testosterone Delivery Profile Observed with Two Different Transdermal Formulations | Amit Misra, Rahul Pal, Subeer S. Majumdar, G. P. Talwar and Om Singh |
| 1269-1271 | Separation and Quantitation of Cationic Liposome Components by High Performance Liquid Chromatography with Evaporative Light-Scattering Detection | Jiin H. Felgner |
| 1272-1274 | Particle Size Distribution of a Suspension Aerosol Using Andersen and Marple-Miller Cascade Impactors | Gowdahalli N. Subba Rao, Donald W. Banick and Daniel M. Pacenti |
| 1275-1277 | X-ray Scattering Analysis of Human Stratum Corneum Treated by High Voltage Pulses | A. Jadoul, V. Regnier, J. Doucet, D. Durand and V. Préat |
| 1278-1281 | Is the Jejunal Permeability in Rats Age-Dependent? | Anders Lindahl, Eva Krondahl, Ann-Charlotte Grudén, Anna-Lena Ungell and Hans Lennernäs |
| 1282-1285 | Evaluation of Drug Absorption After Intrapulmonary Administration Using Xenopus Pulmonary Membranes: Correlation with In Vivo Pulmonary Absorption Studies in Rats | Shigeki Okumura, Hideaki Tanaka, Keiko Shinsako, Mayuko Ito and Akira Yamamoto, et al. |
| 1287-1297 | Validation of a Decision Support System for Use in Drug Development: Pharmacokinetic Data | Serge Guzy and Anthony Hunt |
| 1298-1308 | The Determinants of Physician Attitudes and Subjective Norms Toward Drug Information Sources: Modification and Test of the Theory of Reasoned Action | Caroline A. Gaither, Richard P. Bagozzi, Frank J. Ascione and Duane M. Kirking |
| 1309-1315 | Cholera Toxin B-Mediated Targeting of Lipid Vesicles Containing Ganglioside GM1 to Mucosal Epithelial Cells | Tianshun Lian and Rodney J. Y. Ho |
| 1316-1321 | Transient Expression of a Purine-Selective Nucleoside Transporter (SPNTint) in a Human Cell Line (HeLa) | Marci E. Schaner, Juan Wang, Shoshana Zevin, Karin M. Gerstin and Kathleen M. Giacomini |
| 1322-1331 | Iontophoresis of Poly-L-lysines: The Role of Molecular Weight? | Norris G. Turner, Laura Ferry, Matthew Price, Christopher Cullander and Richard H. Guy |
| 1332-1340 | The Effect of β-Turn Structure on the Passive Diffusion of Peptides Across Caco-2 Cell Monolayers | Gregory T. Knipp, David G. Vander Velde, Teruna J. Siahaan and Ronald T. Borchardt |
| 1341-1348 | The Effect of β-Turn Structure on the Permeation of Peptides Across Monolayers of Bovine Brain Microvessel Endothelial Cells | Mette Sorensen, Betina Steenberg, Gregory T. Knipp, Wen Wang and Bente Steffansen, et al. |
| 1349-1354 | Molecular Modeling of Polymers 16. Gaseous Diffusion in Polymers: A Quantitative Structure-Property Relationship (QSPR) Analysis | Hitesh C. Patel, John S. Tokarski and A. J. Hopfinger |
| 1355-1362 | On the Variability of Dissolution Data | Zeev Elkoshi |
| 1363-1369 | Evaluation of Direct Curve Comparison Metrics Applied to Pharmacokinetic Profiles and Relative Bioavailability and Bioequivalence | S. A. Marston and James E. Polli |
| 1370-1378 | Long-Term and High-Temperature Storage of Supercritically-Processed Microparticulate Protein Powders | Michael A. Winters, Pablo G. Debenedetti, Jannette Carey, H. Gerald Sparks and Samir U. Sane, et al. |
| 1379-1387 | The Stability of Insulin in Crystalline and Amorphous Solids: Observation of Greater Stability for the Amorphous Form | Michael J. Pikal and Daniel R. Rigsbee |
| 1388-1393 | Interaction of Human IgE with Soluble Forms of IgE High Affinity Receptors | Jim Liu, Jane Ruppel and Steven J. Shire |
| 1394-1400 | Development and Use of Enzyme-Linked Immunosorbent Assays (ELISA) for the Detection of Protein Aggregates in Interferon-Alpha (IFN-α) Formulations | Andrea Braun and Jochem Alsenz |
| 1401-1405 | Protection Afforded by Maltosyl-β-cyclodextrin Against α-Chymotrypsin-Catalyzed Hydrolysis of a Luteinizing Hormone-Releasing Hormone Agonist, Buserelin Acetate | Kazutaka Matsubara, Yukihiro Ando, Tetsumi Irie and Kaneto Uekama |
| 1406-1414 | Stabilization of 10-Hydroxycamptothecin in Poly(lactide-co-glycolide) Microsphere Delivery Vehicles | Anna Shenderova, Thomas G. Burke and Steven P. Schwendeman |
| 1415-1421 | A New Ternary Polymeric Matrix System for Controlled Drug Delivery of Highly Soluble Drugs: I. Diltiazem Hydrochloride | Hyunjo Kim and Reza Fassihi |
| 1422-1430 | Characterization of Poly(glycolide-co-D,L-lactide)/Poly(D,L-lactide) Microspheres for Controlled Release of GM-CSF | Dean K. Pettit, J. Ronald Lawter, W. James Huang, Susan C. Pankey and Nancy S. Nightlinger, et al. |
| 1431-1436 | Chitosan and Chitosan/Ethylene Oxide-Propylene Oxide Block Copolymer Nanoparticles as Novel Carriers for Proteins and Vaccines | Pilar Calvo, Carmen Remuñan-López, Jose Luis Vila-Jato and María José Alonso |
| 1437-1443 | Effect of Drug Load and Plate Coating on the Particle Size Distribution of a Commercial Albuterol Metered Dose Inhaler (MDI) Determined Using the Andersen and Marple-Miller Cascade Impactors | Moheb M. Nasr, Danna L. Ross and Nicholas C. Miller |
| 1444-1448 | Glucuronidation of Entacapone, Nitecapone, Tolcapone, and Some Other Nitrocatechols by Rat Liver Microsomes | Pia Lautala, Maija Kivimaa, Hannele Salomies, Eivor Elovaara and Jyrki Taskinen |
| 1449-1454 | Biomimetic Metabolism of Artelinic Acid by Chemical Cytochrome P-450 Model Systems | Olutosin R. Idowu, Ai J. Lin, James M. Grace and James O. Peggins |
| 1455-1460 | The Design and Validation of a Novel Intravenous Microdialysis Probe: Application to Fluconazole Pharmacokinetics in the Freely-Moving Rat Model | Hua Yang, Qin Wang and William F. Elmquist |
| 1461-1465 | The Pharmacokinetics of Topotecan and Its Carboxylate Form Following Separate Intravenous Administration to the Dog | Brian E. Davies, Elisabeth A. Minthorn, Michael J. Dennis, Hilde Rosing and Jos H. Beijnen |
| 1466-1471 | Effects of Low and High Density Lipoproteins on Renal Cyclosporine A and Cyclosporine G Disposition in the Isolated Perfused Rat Kidney | Michelle L. Strong and Clarence T. Ueda |
| 1472-1478 | Protein Aggregates Seem to Play a Key Role Among the Parameters Influencing the Antigenicity of Interferon Alpha (IFN-α) in Normal and Transgenic Mice | Andrea Braun, Lia Kwee, Mark A. Labow and Jochem Alsenz |
| 1479-1484 | Lymphatic Uptake and Biodistribution of Liposomes After Subcutaneous Injection: III. Influence of Surface Modification with Poly(ethyleneglycol) | Christien Oussoren and Gert Storm |
| 1485-1489 | Relationship Between Size of Injected Microspheres and Ultrasound Imaging of Heart by PLSR | K. Dyrstad and P. C. Sontum |
| 1490-1492 | A New Approach for Direct In Vivo Dissolution Studies of Poorly Soluble Drugs | Lisbet Bønløkke, Finn Norring Christensen, Lars Knutson, Henning Gjelstrup Kristensen and Hans Lennernäs |
| 1493-1498 | Burger's Medicinal Chemistry and Drug Discovery. Manfred E. Wolff, Ed. John Wiley & Sons, Inc., One Wiley Drive, Somerset, NJ 08875. |
| 1499 | News from the National Institute of General Medical Sciences (NIGMS) | Rochelle M. Long |
| 1500-1503 | Interview with a Distinguished Pharmaceutical Scientist: Ronald T. Borchardt, Ph.D., Recipient of the 1997 AAPS Distinguished Pharmaceutical Scientist Award |
| 1504-1510 | Preclinical Drug Metabolism in the Age of High-Throughput Screening: An Industrial Perspective | A. David Rodrigues |
| 1511-1515 | Purification of Proteins Using Foam Fractionation | Christopher E. Lockwood, Paul M. Bummer and Michael Jay |
| 1516-1523 | Stereoselectivity of Antibodies for the Bioanalysis of Chiral Drugs | Pierre A. Got and Jean-Michel Scherrmann |
| 1524-1532 | Functional and Molecular Characteristics of Na+-dependent Nucleoside Transporters | Juan Wang, Marci E. Schaner, Silja Thomassen, Sheng-Fang Su and Micheline Piquette-Miller, et al. |
| 1533-1541 | Evolutionary Relationships Among Proteins Probed by an Iterative Neighborhood Cluster Analysis (INCA). Alignment of Bacteriorhodopsins with the Yeast Sequence YRO2 | Richard C. Graul and Wolfgang Sadée |
| 1542-1547 | Tetrafluoroethane (RFC 134A) Propellant-Driven Aerosols of Proteins | Alan R. Brown and David W. George |
| 1548-1555 | Real-Time in Situ Monitoring of Lysozyme During Lyophilization Using Infrared Spectroscopy: Dehydration Stress in the Presence of Sucrose | Richard L. Remmele, Cecil Stushnoff and John F. Carpenter |
| 1556-1562 | Biological Activity of Lysozyme After Entrapment in Poly (d,l-lactide-co-glycolide)-Microspheres | Raouf Ghaderi and Johan Carlfors |
| 1563-1567 | Absorption of D-Glucose in the Rat Studied Using In Situ Intestinal Perfusion: A Permeability-Index Approach | Yanfeng Wang, Renee Aum and Francis L. S. Tse |
| 1568-1573 | The Mechanism of Uptake of Biodegradable Microparticles in Caco-2 Cells Is Size Dependent | Manisha P. Desai, Vinod Labhasetwar, Elke Walter, Robert J. Levy and Gordon L. Amidon |
| 1574-1582 | lonization and Solubilization of 4 Alkyl Benzole Acids and 4 Alkyl Anilines in Sodium Taurodeoxycholate Solutions | Timothy S. Wiedmann, Kristen Kvanbeck, Chien-Hsuan Han and Vikram Roongta |
| 1583-1588 | Time-dependent Pharmacokinetics of High Dose Thiopental Infusion in Intensive Care Patients | Hélène Russo, Marie P. Dubboin, Françoise Bressolle and Saïk Urien |
| 1589-1596 | Understanding How Elderly Patients Process Drug Information: A Test of a Theory of Information Processing | Thomas P. Christensen, Frank J. Ascione and Richard P. Bagozzi |
| 1597-1600 | Influence of Dosage Form on the Gastroenteropathy of Flurbiprofen in the Rat: Evidence of Shift in the Toxicity Site | Neal M. Davies and Fakhreddin Jamali |
| 1601-1606 | Pharmacodynamic Modeling for Change of Locomotor Activity by Methylphenidate in Rats | Takao Aoyama, Koujirou Yamamoto, Hajime Kotaki, Yasufumi Sawada and Tatsuji Iga |
| 1607-1612 | Species Differences of Serum Albumins: I. Drug Binding Sites | Takamitsu Kosa, Toru Maruyama and Masaki Otagiri |
| 1613-1620 | Differences in Lipoprotein Lipid Concentration and Composition Modify the Plasma Distribution of Cyclosporine | Kishor M. Wasan, P. Haydn Pritchard, Manisha Ramaswamy, Wesley Wong and Elizabeth M. Donnachie, et al. |
| 1621-1628 | Pharmacokinetic and Pharmacological Profiles of Free and Liposomal Recombinant Human Erythropoietin After Intravenous and Subcutaneous Administrations in Rats | Hidetaka Moriya, Yoshie Maitani, Naoto Shimoda, Kozo Takayama and Tsuneji Nagai |
| 1629-1633 | Activation of the Mononuclear Phagocyte System by Poloxamine 908: Its Implications for Targeted Drug Delivery | T. I. Armstrong, S. M. Moghimi, S. S. Davis and L. Illum |
| 1634-1639 | Acyloxymethyl as a Drug Protecting Group: Part 4. The Hydrolysis of Tertiary Amidomethyl Ester Prodrugs of Carboxylic Acid Agents | Jim Iley, Rui Moreira, Teresa Calheiros and Eduarda Mendes |
| 1640-1643 | Distribution Kinetics of Diazepam, Lidocaine and Antipyrine in the Isolated Perfused Rat Hindlimb | Michael Weiss, Armin Koester, Zhen Yu Wu and Michael S. Roberts |
| 1644-1646 | Bioavailability of Hydrochlorothiazide from Pellets, Made by Extrusion/ Spheronisation, Containing Polyethylene Glycol 400 as a Dissolution Enhancer | Chris Vervaet and Jean Paul Remon |
| 1647-1650 | Cellulase-Catalyzed Transglucosylation of Acetaminophen and Acyclovir: Preparative Enzymatic Synthesis of β-glucose Conjugate | Takashi Mizuma, Satoshi Masubuchi and Shoji Awazu |
| 1651-1654 | An Interview with a Distinguished Pharmaceutical Scientist: William M. Pardridge, Recipient of the AAPS Meritorious Manuscript Award |
| 1655-1658 | Intestinal Drug Absorption and Metabolism in Cell Cultures: Caco-2 and Beyond | Per Artursson and Ronald T. Borchardt |
| 1659-1671 | Apoptosis: A New Pharmacodynamic Endpoint | Jessie L.-S. Au, Neeraj Panchal, Dong Li and Yuebo Gan |
| 1672-1678 | Promoter and Intronic Sequences of the Human Thiopurine S-Methyltransferase (TPMT) Gene Isolated from a Human Pacl Genomic Library | Eugene Y. Krynetski, Michael Y. Fessing, Charles R. Yates, Daxi Sun and John D. Schuetz, et al. |
| 1679-1684 | Recombinant Factor VIII SQ- Inactivation Kinetics in Aqueous Solution and the Influence of Disaccharides and Sugar Alcohols | Angelica Fatouros, Thomas Österberg and Marianne Mikaelsson |
| 1685-1690 | The Stability and Degradation Pathway of Recombinant Human Parathyroid Hormone: Deamidation of Asparaginyl Residue and Peptide Bond Cleavage at Aspartyl and Asparaginyl Residues | Yoshiaki Nabuchi, Eri Fujiwara, Hitoshi Kuboniwa, Yoshinori Asoh and Hidetoshi Ushio |
| 1691-1698 | Spectroscopic Characterization of Interactions Between PVP and Indomethacin in Amorphous Molecular Dispersions | Lynne S. Taylor and George Zografi |
| 1699-1705 | Chromatographic Indexes on Immobilized Artificial Membranes for Local Anesthetics: Relationships with Activity Data on Closed Sodium Channels | Francesco Barbato, Maria I. La Rotonda and Fabiana Quaglia |
| 1706-1712 | Analysis of Drug/Plasma Protein Interactions by Means of Asymmetrical Flow Field-Flow Fractionation | Maya Madörin, Peter van Hoogevest, Rolf Hilfiker, Birgit Langwost and Gerhard M. Kresbach, et al. |
| 1713-1717 | Study of the Complex Between the Contrast Agent lobitridol (Xenetix®) and Elastase (PPE): A Model for Hydrophobic Site Protection in Drug-Protein Interactions | Thierry Prangé, Alain Neuman, Claire Corot and Dominique Meyer |
| 1718-1725 | Variability in Size Distribution Measurements Obtained Using Multiple Andersen Mark II Cascade Impactors | Stephen W. Stein and Bernard A. Olson |
| 1726-1729 | In Vivo and In Vitro Diclofenac Sodium Evaluation After Rectal Application of Soft Gelatine Capsules Enabling Application Induced Transformation (AIT) into a Semisolid System of Liquid Crystals (SSLC) for Controlled Release | Axel Schneeweis and Christel C. Müller-Goymann |
| 1730-1737 | Inulin Hydrogels as Carriers for Colonic Drug Targeting: I. Synthesis and Characterization of Methacrylated Inulin and Hydrogel Formation | Liesbeth Vervoort, Guy Van den Mooter, Patrick Augustijns, Roger Busson and Suzanne Toppet, et al. |
| 1738-1743 | Effects of Topical alpha-Substituted Anandamides on Intraocular Pressure in Normotensive Rabbits | David W. Pate, Kristiina Järvinen, Arto Urtti, Pekka Jarho and Vaidyanath Mahadevan, et al. |
| 1744-1749 | Prednicarbate Versus Conventional Topical Glucocorticoids: Pharmacodynamic Characterization In Vitro | Katharina Lange, Anja Gysler, Michael Bader, Burkhard Kleuser and Hans Christian Korting, et al. |
| 1750-1758 | Studies on Agents with Mixed NO-Dependent Vasodilating and β-Blocking Activities | Donatella Boschi, Antonella Di Stilo, Clara Cena, Marco Lolli and Roberta Fruttero, et al. |
| 1759-1764 | Cellular Delivery of Oligonucleotides by Synthetic Import Peptide Carrier | Sujatha Dokka, David Toledo-Velasquez, Xianglin Shi, Liying Wang and Yon Rojanasakul |
| 1765-1771 | The Effects of Hexetidine (Oraldene™) on the Adherence of Candida Albicans to Human Buccal Epithelial Cells In Vitro and Ex Vivo and on In Vitro Morphogenesis | David S. Jones, James G. McGovern, A. David Woolfson and Sean P. Gorman |
| 1772-1779 | Heparin Absorption Across the Intestine: Effects of Sodium N-[8-(2-Hydroxybenzoyl)Amino]Caprylate in Rat In Situ Intestinal Instillations and in Caco-2 Monolayers | David Brayden, Elizabeth Creed, Alan O'Connell, Harry Leipold and Rajesh Agarwal, et al. |
| 1780-1785 | Rat Jejunal Permeability and Metabolism of μ-Selective Tetrapeptides in Gastrointestinal Fluids from Humans and Rats | Eva Krondahl, Achim Orzechowski, Gunilla Ekström and Hans Lennernäs |
| 1786-1791 | Theoretical Calculation and Prediction of Caco-2 Cell Permeability Using MolSurf Parametrization and PLS Statistics | Ulf Norinder, Thomas Österberg and Per Artursson |
| 1792-1797 | Improved Prediction of In Vivo Peroral Absorption from In Vitro Intestinal Permeability Using an Internal Standard to Control for Intra- and Inter-Rat Variability | Martin E. Dowty and Charles R. Dietsch |
| 1798-1803 | lontophoretic Delivery of Apomorphine I: In Vitro Optimization and Validation | Ronald van der Geest, Meindert Danhof and Harry E. Boddé |
| 1804-1810 | lontophoretic Delivery of Apomorphine II: An In Vivo Study in Patients with Parkinson's Disease | Ronald van der Geest, Teus van Laar, Josy M. Gubbens-Stibbe, Harry E. Boddé and Meindert Danhof |
| 1811-1816 | Stereoselective Disposition of Suspensions of Conventional and Wax-matrix Sustained Release Ibuprofen Microspheres in Rats | Christianah Moji Adeyeye and Fen-Fang Chen |
| 1817-1823 | The Pharmacokinetics and Electroencephalogram Response of Remifentanil Alone and in Combination with Esmolol in the Rat | Sam H. Haidar, J. Edward Moreton, Zhongming Liang, John R Hoke and Keith T. Muir, et al. |
| 1824-1829 | Metabolism and Pharmacokinetics of Novel Oral Prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in Dogs | Jeng-Pyng Shaw, Cathy M. Sueoka, Reza Oliyai, William A. Lee and Murty N. Arimilli, et al. |
| 1830-1834 | Oral Delivery of Heparin in Combination with Sodium N-[8-(2-Hydroxybenzoyl)amino]caprylate: Pharmacological Considerations | Theresa M. Rivera, Andrea Leone-Bay, Duncan R. Paton, Harry R. Leipold and Robert A. Baughman |
| 1835-1837 | Evaluation of Biocoat® Intestinal Epithelium Differentiation Environment (3-Day Cultured Caco-2 Cells) as an Absorption Screening Model with Improved Productivity | Saeho Chong, Sandra A. Dando and Richard A. Morrison |
| 1838-1841 | Freeze-Drying of Poly((2-dimethylamino)ethyl Methacrylate)-Based Gene Delivery Systems | Jong-Yuh Cherng, Petra van de Wetering, Herre Talsma, Daan J. A. Crommelin and Wim E. Hennink |
| 1842-1844 | Reviewers for Pharmaceutical Research November 1996 Through October 1997 |
| 1845-1848 | Author Index to Volume 14 (1997) |
| 1849-1853 | Subject Index to Volume 14 (1997) |
| 1 | Comparative Pharmacokinetics and Pharmacodynamics of Two Recombinant Human Interferon Beta la (IFNβ-1a) Products Administered Intramuscularly in Healthy Male and Female Volunteers | Silvano Fumero |
| 2-3 | Comparative Pharmacokinetics and Pharmacodynamics of Two Recombinant Human Interferon Beta la (IFNβ-1a) Products Administered Intramuscularly in Healthy Male and Female Volunteers | Ernest C. Borden |
| 4-7 | Evaluation of the Proposed FDA Pilot Dose-response Methodology for Topical Corticosteroid Bioequivalence Testing | Gur Jai Pal Singh, Nicholas Fleischer, Lawrence Lesko and Roger Williams |
| 8-10 | Education in Pharmaceutical Sciences Needs a Brand New Direction to Meet the Challenges of Drug Research and Development | Abu T. M. Serajuddin |
| 11-22 | Dissolution Testing as a Prognostic Tool for Oral Drug Absorption: Immediate Release Dosage Forms | Jennifer B. Dressman, Gordon L. Amidon, Christos Reppas and Vinod P. Shah |
| 23-30 | The How and Why of Protein-carbohydrate Interaction: A Primer to the Theoretical Concept and a Guide to Application in Drug Design | Hans-Joachim Gabius |
| 31-38 | Design, Synthesis, and Biological Evaluation of Spider Toxin (Argiotoxin-636) Analogs as NMDA Receptor Antagonists | Scott T. Moe, Daryl L. Smith, Yongwei (Eric) Chien, Joanna L. Raszkiewicz and Linda D. Artman, et al. |
| 39-46 | Synthesis and Anti-inflammatory Effect of Chalcones and Related Compounds | Hsin-Kaw Hsieh, Tai-Hua Lee, Jih-Pyang Wang, Jeh-Jeng Wang and Chun-Nan Lin |
| 47-52 | Human Drug Absorption Kinetics and Comparison to Caco-2 Monolayer Permeabilities | James E. Polli and Mark J. Ginski |
| 53-57 | Modulation of the Tight Junctions of the Caco-2 Cell Monolayers by H2-antagonists | Liang-Shang L. Gan, Souzan Yanni and Dhiren R. Thakker |
| 58-65 | Influence of Chitosan Microspheres on the Transport of Prednisolone Sodium Phosphate Across HT-29 Cell Monolayers | Frank Ch. Mooren, Achim Berthold, Wolfram Domschke and Jörg Kreuter |
| 66-71 | The Influence of Intestinal Mucus Components on the Diffusion of Drugs | Agneta Wikman Larhed, Per Artursson and Erik Björk |
| 72-76 | Effects of Organic Anions and Bile Acid Conjugates on Biliary Excretion of Pravastatin in the Rat | Satoko Fukumura, Hajime Takikawa and Masami Yamanaka |
| 77-81 | Nasal Absorption Kinetic Behavior of Azetirelin and Its Enhancement by Acylcarnitines in Rats | Seiya Kagatani, Noriko Inaba, Muneo Fukui and Takashi Sonobe |
| 82-84 | Human Cadaver Skin Viability for In Vitro Percutaneous Absorption: Storage and Detrimental Effects of Heat-Separation and Freezing | Ronald C. Wester, Julie Christoffel, Tracy Hartway, Nicholas Poblete and Howard I. Maibach, et al. |
| 85-92 | Low Intensity Ultrasound as a Probe to Elucidate the Relative Follicular Contribution to Total Transdermal Absorption | V. M. Meidan, M. Docker, A. D. Walmsley and W. J. Irwin |
| 93-97 | Rapid Determination of Oral Pharmacokinetics and Plasma Free Fraction Using Cocktail Approaches: Methods and Application | Mary C. Alien, Toral S. Shah and Wesley W. Day |
| 98-104 | Evaluation of Bioequivalence of Highly Variable Drugs Using Clinical Trial Simulations. II: Comparison of Single and Multiple-Dose Trials Using AUC and Cmax | Ahmed A. El-Tahtawy, Thomas N. Tozer, Ferrin Harrison, Larry Lesko and Roger Williams |
| 105-109 | Health Status Utility Assessment by Standard Gamble: A Comparison of the Probability Equivalence and the Lottery Equivalence Approaches | Anandi V. Law, Dev S. Pathak and Mark R. McCord |
| 110-115 | A 31P CP/MAS NMR Study on Dehydration of Disodium Clodronate Tetrahydrate | Juha T. Timonen, Esko Pohjala, Hannu Nikander and Tuula T. Pakkanen |
| 116-121 | Terplex DNA Delivery System As a Gene Carrier | Jin-Seok Kim, Atsushi Maruyama, Toshihiro Akaike and Sung Wan Kim |
| 122-127 | Cytostatic and Apoptotic Effects of Paclitaxel in Human Ovarian Tumors | Nancy J. Millenbaugh, Yuebo Gan and Jessie L.-S. Ail |
| 128-132 | Effect of Particle Size and Charge on the Disposition of Lipid Carriers After Intratumoral Injection into Tissue-isolated Tumors | Takehiko Nomura, Noriko Koreeda, Fumiyoshi Yamashita, Yoshinobu Takakura and Mitsuru Hashida |
| 133-138 | Determination of Free Extracellular Levels of Methotrexate by Microdialysis in Muscle and Solid Tumor of the Rabbit | Sylvain Dukic, Matthieu L. Kaltenbach, Bertrand Gourdier, Helene Marty and Richard Vistelle |
| 139-144 | Tissue Disposition of Zidovudine and Its Phosphorylated Metabolites in Zidovudine-treated Healthy and Retrovirus Infected Mice | Hsiao-Hui Chow, Gary Brookshier and Ping Li |
| 145-148 | Unusual Reduction of the In Vitro Skin Permeation of [3H]dexetimide by Atropine | Ingrid J. Bosman, Kees Ensing and Rokus A. de Zeeuw |
| 149-152 | The Effect of Jet-Milling on Lyophilized Liposomes | W. Cary Mobley |
| 153-156 | Utilizing Bacterial Mechanisms of Epithelial Cell Entry: Invasin-induced Oral Uptake of Latex Nanoparticles | Nasir Hussain and Alexander T. Florence |
| 157-160 | BOOK REVIEWS |
| 161-162 | Editorial |
| 163-164 | CHANGES ON THE EDITORIAL TEAM FOR PHARMACEUTICAL RESEARCH |
| 165-166 | News From the National Institute of General Medical Sciences (NIGMS) | Rochelle M. Long |
| 167-171 | Bioequivalence of Topical Dermatological Dosage Forms-Methods of Evaluation of Bioequivalence | Vinod P. Shah, Gordon L. Flynn, Avraham Yacobi, Howard I. Maibach and Charles Bon, et al. |
| 172-174 | Economics of Drug Delivery | Rob Chess |
| 175-187 | DNA Methylation as a Target for Drug Design | Christina M. Bender, Jean-Marc Zingg and Peter A. Jones |
| 188-193 | Hydrophobic Ion Pairing: Altering the Solubility Properties of Biomolecules | Jeffrey D. Meyer and Mark C. Manning |
| 194-199 | Characterization of Frozen Aqueous Solutions by Low Temperature X-ray Powder Diffractometry | Raghu K. Cavatur and Raj Suryanarayanan |
| 200-208 | Interleukin-1 Receptor (IL-1R) Liquid Formulation Development Using Differential Scanning Calorimetry | Richard L. Remmele, Nancy S. Nightlinger, Subhashini Srinivasan and Wayne R. Gombotz |
| 209-215 | pH-Metric logP 10. Determination of Liposomal Membrane-Water Partition Coefficients of lonizable Drugs | A. Avdeef, K. J. Box, J. E. A. Comer, C. Hibbert and K. Y. Tam |
| 216-220 | The Role of the Drug/Excipient Particle Size Ratio in the Percolation Model for Tablets | Mónica Millán, Isidore Caraballo and Antonio María Rabasco |
| 221-227 | Reduced Systemic Availability of an Antiarrhythmic Drug, Bidisomide, with Meal Co-administration: Relationship with Region-Dependent Intestinal Absorption | Li-Heng Pao, Simon Yuji Zhou, Chyung Cook, Tugrul Kararli and Carol Kirchhoff, et al. |
| 228-232 | Risedronate Gastrointestinal Absorption Is Independent of Site and Rate of Administration | David Y. Mitchell, Rachelle A. Eusebio, Lisa E. Dunlap, Karen A. Pallone and John D. Nesbitt, et al. |
| 233-238 | Drug Marker Absorption in Relation to Pellet Size, Gastric Motility and Viscous Meals in Humans | Julie K. Rhie, Yayoi Hayashi, Lynda S. Welage, Jeremy Frens and Randy J. Wald, et al. |
| 239-245 | Comparison of the Disposition of Ester Prodrugs of the Antiviral Agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 Monolayers | P. Annaert, G. Gosselin, A. Pompon, S. Benzaria and G. Valette, et al. |
| 246-253 | Permeation of Unfolded Basic Fibroblast Growth Factor (bFGF) Across Rabbit Buccal Mucosa—Does Unfolding of bFGF Enhance Transport? | Thomas P. Johnston, Atiq Rahman, Hemant Alur, Dipesh Shah and Ashim K. Mitra |
| 254-262 | Effects of Non-Covalent Self-Association on the Subcutaneous Absorption of a Therapeutic Peptide | Dean K. Clodfelter, Allen H. Pekar, Dawn M. Rebhun, Kevin A. Destrampe and Henry A. Havel, et al. |
| 263-269 | Synthesis and In Vitro Evaluation of Chitosan-EDTA-Protease-Inhibitor Conjugates Which Might Be Useful in Oral Delivery of Peptides and Proteins | Andreas Bernkop-Schnürch and Andreas Scerbe-Saiko |
| 270-275 | Stealth PLA-PEG Nanoparticles as Protein Carriers for Nasal Administration | M. Tobío, R. Gref, A. Sánchez, R. Langer and M. J. Alonso |
| 276-279 | Why Rate of Absorption Inferences in Single Dose Bioequivalence Studies are Often Inappropriate | Rodney P. Basson, Atalanta Ghosh, Benito J. Cerimele, Karl A. DeSante and Daniel C. Howey |
| 280-285 | Analysis of Chromameter Results Obtained from Corticosteroid-Induced Skin Blanching. I: Manipulation of Data | Eric W. Smith, John M. Haigh and Roderick B. Walker |
| 286-295 | Dihydroorotate Dehydrogenase Inhibitors: Quantitative Structure-activity Relationship Analysis | Shijun Ren, Sharon K. Wu and Eric J. Lien |
| 296-302 | Biochemical Characterization of a Glucocorticoid-Induced Membrane Protein (RM3/1) in Human Monocytes and Its Application as Model System for Ranking Glucocorticoid Potency | Petra Högger, Uta Erpenstein, Peter Rohdewald and Clemens Sorg |
| 303-311 | Pharmacological Activity and Membrane Interactions of Antiarrhythmics: 4D-QSAR/QSPR Analysis | Christian D. P. Klein and A. J. Hopfinger |
| 312-317 | Influence of Surface Properties at Biodegradable Microsphere Surfaces: Effects on Plasma Protein Adsorption and Phagocytosis | F. X. Lacasse, M. C. Filion, N. C. Phillips, E. Escher and J. N. McMullen, et al. |
| 318-324 | Modification of the Copolymers Poloxamer 407 and Poloxamine 908 can Affect the Physical and Biological Properties of Surface Modified Nanospheres | Jonathan C. Neal, S. Stolnik, M. C. Garnett, Stanley S. Davis and Lisbeth Illum |
| 325-333 | Efficacy and Pharmacokinetics of Site-Specific Cefazolin Delivery Using Biodegradable Implants in the Prevention of Post-operative Wound Infections | Saleh Allababidi and Jaymin C. Shah |
| 334-337 | DQAsomes: A Novel Potential Drug and Gene Delivery System Made from Dequalinium™ | Volkmar Weissig, Jürgen Lasch, Gregory Erdos, Helmut W. Meyer and Thomas C. Rowe, et al. |
| 338-342 | Development and Utility of Anti-PepTl Anti-Peptide Polyclonal Antibodies | Sujit K. Basu, Jie Shen, Katharina J. Elbert, Curtis T. Okamoto and Vincent H. L. Lee, et al. |
| 343-346 | Reaction of Acyl Glucuronides with Insulin In Vitro: Identification of an Imine Mechanism by Electrospray lonization Mass Spectrometry | J. H. Liu, C. D. Marquez, S. T. Weintraub and P. C. Smith |
| 347-351 | Use of the Stable Isotopes Technique to Evaluate the Bioavailability of a Pharmaceutical Form of Magnesium in Man | Henri Benech, Alain Pruvost, Alain Batel, Michel Bourguignon and Jean-Louis Thomas, et al. |
| 352-356 | A Cross-Section Device To Improve Visualization of Fluorescent Probe Penetration into the Skin by Confocal Laser Scanning Microscopy | Marly E. M. J. Meuwissen, Jan Janssen, Chris Cullander, Hans E. Junginger and Joke A. Bouwstra |
| 357-361 | A Large-Scale Process to Produce Microencapsulated Proteins | Paul Herbert, Keith Murphy, OluFunmi Johnson, Nan Dong and Warren Jaworowicz, et al. |
| 362-363 | ERRATUM |
| 365-367 | An Interview with a Distinguished Pharmaceutical Scientist: Joseph R. Robinson; To whom correspondence should be addressed at University of Wisconsin, School of Pharmacy, 425 N. Charter St., Madison, Wisconsin 53706-1515. |
| 368-370 | Recent Advances in Structure-Based Ligand Design Using Molecular Dynamics and Monte Carlo Methods | Peter Kollman |
| 371-376 | Drug Exsorption from Blood into the Gastrointestinal Tract | Kazuhiko Arimori and Masahiro Nakano |
| 377-385 | Localized Delivery of Proteins in the Brain: Can Transport Be Customized? | Michael F. Haller and W. Mark Saltzman |
| 386-398 | Advances and Challenges in the Prevention and Treatment of Alzheimer's Disease | Roberta Diaz Brinton and Rose S. Yamazaki |
| 399-404 | The Duration of Measuring Partial AUCs for the Assessment of Bioequivalence | Laszlo Endrenyi, Ferenc Csizmadia, Laszlo Tothfalusi, Alfred H. Balch and Mei-Ling Chen |
| 405-410 | Coverage and Precision of Confidence Intervals for Area Under the Curve Using Parametric and Non-parametric Methods in a Toxicokinetic Experimental Design | Peter L. Bonate |
| 411-416 | Possible Role of Anion Exchanger AE2 as the Intestinal Monocarboxylic Acid/Anion Antiporter | Hikaru Yabuuchi, Ikumi Tamai, Yoshimichi Sai and Akira Tsuji |
| 417-422 | The Use of Pharmacoscintigraphy to Elucidate Food Effects Observed with a Novel Protease Inhibitor (Saquinavir) | C. J. Kenyon, F. Brown, G. R. McClelland and I. R. Wilding |
| 423-428 | Active Apical Secretory Efflux of the HIV Protease Inhibitors Saquinavir and Ritonavir in Caco-2 Cell Monolayers | Jochem Alsenz, Hans Steffen and Rainer Alex |
| 429-433 | Mechanism of Compound- and Species-Specific Food Effects of Structurally Related Antiarrhythmic Drugs, Disopyramide and Bidisomide | Chyung S. Cook, Liming Zhang, John Osis, Grant L. Schoenhard and Aziz Karim |
| 434-441 | Stability of Alkoxycarbonylamidine Prodrugs | Zahra Shahrokh, Eric Lee, Alan G. Olivero, Regina A. Matamoros and Kirk D. Robarge, et al. |
| 442-448 | Influence of Different Fat Emulsion-Based Intravenous Formulations on the Pharmacokinetics and Pharmacodynamics of Propofol | Eugene H. Cox, Catherijne A. J. Knibbe, Victorine S. Koster, Mariska W. E. Langemeijer and Erica E. Tukker, et al. |
| 449-454 | Species Differences of Serum Albumins: II. Chemical and Thermal Stability | Takamitsu Kosa, Toru Maruyama and Masaki Otagiri |
| 455-460 | Inhibition of Tracheal Vascular Extravasation by Liposome-Encapsulated Albuterol in Rats | Weiming Zhang, Luke Guo, Jay A. Nadel and Demetrios Papahadjopoulos |
| 461-465 | Effect of Dose and Release Rate on Pulmonary Targeting of Liposomal Triamcinolone Acetonide Phosphate | Sandra Suarez, Ricardo J. Gonzalez-Rothi, Hans Schreier and Günther Hochhaus |
| 466-473 | Development and Internal Validation of an In Vitro-in Vivo Correlation for a Hydrophilic Metoprolol Tartrate Extended Release Tablet Formulation | Natalie D. Eddington, Patrick Marroum, Ramana Uppoor, Ajaz Hussain and Larry Augsburger |
| 474-481 | Pulsatile Drug Release from an Insoluble Capsule Body Controlled by an Erodible Plug | Ina Krögel and Roland Bodmeier |
| 482-487 | Controlled Release Gel of Ibuprofen and Lidocaine in Epidural Use—Analgesia and Systemic Absorption in Pigs | Anne Paavola, Pekka Tarkkila, Mei Xu, Torsten Wahlström and Jouko Yliruusi, et al. |
| 488-491 | Pharmacokinetics of Cocaine and Metabolites Following Intragastric Administration to Ten-Day-Old Rat Pups | Nasser N. Nyamweya, Bill J. Gurley, Phil Breen and Kim E. Light |
| 492-494 | Stratum Corneum Thickness and Apparent Water Diffusivity: Facile and Noninvasive Quantitation In Vivo | Fabrice Pirot, Enzo Berardesca, Yogeshvar N. Kalia, Malkiat Singh and Howard I. Maibach, et al. |
| 495-498 | Lipid Extracting Effect of Ethanol on Keratinized Oral Mucosa | Adriana Ganem-Quintanar, Yves Jacques, Françoise Falson-Rieg and Pierre Buri |
| 499-501 | Negative Correlation of n-Octanol/ Water Partition Coefficient and Transport of Some Guanine Derivatives Through Rat Jejunum In Vitro | Albin Kristl and Josef J. Tukker |
| 502-503 | Modeling Mucoadhesion by Use of Surface Energy Terms Obtained by the Lewis Acid-Lewis Base Approach: III. An Interaction Between Teflon and Carbopol | Graham Buckton and Marco Montagno Cappuccinello |
| 504-507 | ERRATUM |
| 509-512 | Microcrystalline Cellulose as a Sponge as an Alternative Concept to the Crystallite-Gel Model for Extrusion and Spheronization | Ragnar Ek and J.Michael Newton |
| 513-514 | News from the National Institute of General Medical Sciences (NIGMS) | Rochelle M. Long |
| 515-516 | Opportunities in Drug Discovery for Treatment of AIDS | Arthur D. Broom |
| 517-524 | Genetic Polymorphism of Drug Metabolizing Enzymes: New Mutations in CYP2D6 and CYP2A6 Genes in Japanese | Tsuyoshi Yokoi and Tetsuya Kamataki |
| 525-530 | Influence of Liposome Bilayer Fluidity on the Transport of Encapsulated Substance into the Skin as Evaluated by EPR | Katarina Vrhovnik, Julijana Kristl, Marjeta Šentjurc and Jelka Šmid-Korbar |
| 531-537 | Synthesis of a Lipophilic Daunoruhicin Derivative and Its Incorporation into Lipidic Carriers Developed for LDL Receptor-Mediated Tumor Therapy | A. Jenny Versluis, Erik T. Rump, Patrick C. N. Rensen, Theo J. C. Van Berkel and Martin K. Bijsterbosch |
| 538-543 | Phase Transformation of a Liposomal Dispersion into a Micellar Solution Induced by Drug-Loading | Wolfgang Schütze and Christel C. Müller-Goymann |
| 544-549 | Drug Targeting by Polyalkylcyanoacrylate Nanoparticles Is Not Efficient Against Persistent Salmonella | Marie-Estelle Page-Clisson, Huguette Pinto-Alphandary, Elisabeth Chachaty, Patrick Couvreur and Antoine Andremont |
| 550-556 | Pegylated Nanoparticles from a Novel Methoxypolyethylene Glycol Cyanoacrylate-Hexadecyl Cyanoacrylate Amphiphilic Copolymer | Maria Teresa Peracchia, Christine Vauthier, Didier Desmaële, Annette Gulik and Jean-Claude Dedieu, et al. |
| 557-561 | The Preparation of Dextran Microspheres in an All-Aqueous System: Effect of the Formulation Parameters on Particle Characteristics | Robert J. H. Stenekes, Okke Franssen, Elvira M. G. van Bommel, Daan J. A. Crommelin and Wim E. Hennink |
| 562-569 | Protein Deposition from Dry Powder Inhalers: Fine Particle Multiplets as Performance Modifiers | Paul Lucas, Kerry Anderson and John N. Staniforth |
| 570-575 | Blood-Brain Barrier Equilibration of Codeine in Rats Studied with Microdialysis | Rujia Xie and Margareta Hammarlund-Udenaes |
| 576-582 | Combined Use of Carboxyl-Directed Protein Pegylation and Vector-Mediated Blood-Brain Barrier Drug Delivery System Optimizes Brain Uptake of Brain-Derived Neurotrophic Factor Following Intravenous Administration | William M. Pardridge, Dafang Wu and Toshiyasu Sakane |
| 583-591 | Pulmonary Bioavailability of a Phosphorothioate Oligonucleotide (CGP 64128A): Comparison with Other Delivery Routes | P. L. Nicklin, D. Bayley, J. Giddings, S. J. Craig and L. L. Cummins, et al. |
| 592-598 | Species Differences of Serum Albumins: III. Analysis of Structural Characteristics and Ligand Binding Properties During N-B Transitions | Takamitsu Kosa, Toru Maruyama, Norifumi Sakai, Naoko Yonemura and Shoji Yahara, et al. |
| 599-605 | Effect of GF120918, a Potent P-glycoprotein Inhibitor, on Morphine Pharmacokinetics and Pharmacodynamics in the Rat | Stephen P. Letrent, Gary M. Pollack, Kenneth R. Brouwer and Kim L. R. Brouwer |
| 606-613 | Bisphosphonates and Tetracycline: Experimental Models for Their Evaluation in Calcium-Related Disorders | Hagit Cohen, Vered Solomon, Ivan S. Alferiev, Eli Breuer and Asher Ornoy, et al. |
| 614-619 | Novel Pharmacokinetic Modelling of Transdermal Nitroglycerin | Barbara Auclair, Gérard Sirois, Anh Ho Ngoc and Murray P. Ducharme |
| 620-625 | Application of Fractal Kinetics for Carrier-Mediated Transport of Drugs Across Intestinal Epithelial Membrane | Takuo Ogihara, Ikumi Tamai and Akira Tsuji |
| 626-631 | Species Differences in Stereoselective Hydrolase Activity in Intestinal Mucosa | Yasushi Yoshigae, Teruko Imai, Akira Horita, Hidenobu Matsukane and Masaki Otagiri |
| 632-640 | In Vitro Methionine Oxidation of Recombinant Human Leptin | Jennifer L. Liu, Kan V. Lu, Tamer Eris, Viswanatham Katta and Keith R. Westcott, et al. |
| 641-649 | Structural and Functional Differences Between Glycosylated and Non-glycosylated Forms of Human Interferon-β (IFN-β) | Laura Runkel, Werner Meier, R. Blake Pepinsky, Michael Karpusas and Adrian Whitty, et al. |
| 650-658 | Isolation and Identification of Peptide Degradation Products of Heat Stressed Pramlintide Injection Drug Product | Carla Hekman, Wade DeMond, Trupti Dixit, Steve Mauch and Marc Nuechterlein, et al. |
| 661-670 | Genetic Vaccines: Strategies for Optimization | Gregory Gregoriadis |
| 671-679 | Aerosol Delivery of Lipid:DNA Complexes to Lungs of Rhesus Monkeys | Ruth J. McDonald, H. Denny Liggitt, Lisa Roche, Hung T. Nguyen and Rodney Pearlman, et al. |
| 680-684 | In Vitro Myotoxicity of Selected Cationic Macromolecules Used in Non-Viral Gene Delivery | Gayle A. Brazeau, Steve Attia, Scott Poxon and Jeffrey A. Hughes |
| 685-689 | Synergistic Antitumor Interaction of Human Monocyte Chemotactant Protein-1 Gene Transfer and Modulator for Tumor-Infiltrating Macrophages | Emi Nakashima, Yuri Kubota, Ryo Matsushita, Eijiro Ozaki and Fujio Ichimura, et al. |
| 690-697 | Bootstrapping for Pharmacokinetic Models: Visualization of Predictive and Parameter Uncertainty | C. Anthony Hunt, Geof H. Givens and Serge Guzy |
| 698-705 | Evaluation of Various Dissolution Media for Predicting In Vivo Performance of Class I and II Drugs | E. Galia, E. Nicolaides, D. Hörter, R. Löbenberg and C. Reppas, et al. |
| 706-711 | Decreased Expression and Activity of P-GIycoprotein in Rat Liver During Acute Inflammation | Micheline Piquette-Miller, Anne Pak, Hani Kim, Reza Anari and Afshin Shahzamani |
| 712-718 | P-Glycoprotein Is More Efficient at Limiting Uptake than Inducing Efflux of Colchicine and Vinblastine in HL-60 Cells | Xavier Declèves, Olivier Chappey, Bernadette Boval, Elisabeth Niel and Jean-Michel Scherrmann |
| 719-725 | Transport Characteristics of Peptidomimetics. Effect of the Pyrrolinone Bioisostere on Transport Across Caco-2 Cell Monolayers | Masao Sudoh, Giovanni M. Pauletti, Wenqing Yao, William Moser and Akihisa Yokoyama, et al. |
| 726-733 | Correlation Between Oral Drug Absorption in Humans, and Apparent Drug Permeability in TC-7 Cells, A Human Epithelial Intestinal Cell Line: Comparison with the Parental Caco-2 Cell Line | Marie-Catherine Grès, Bernard Julian, Martine Bourrié, Viviane Meunier and Claude Roques, et al. |
| 734-738 | Effects of Fosfomycin and Imipenem/ Cilastatin on Nephrotoxicity and Renal Excretion of Vancomycin in Rats | Tsutomu Nakamura, Yukiya Hashimoto, Toshiyuki Kokuryo and Ken-Ichi Inui |
| 739-744 | Towards the Predictability of Drug-Lipid Membrane Interactions: The pH-Dependent Affinity of Propranolol to Phosphatidylinositol Containing Liposomes | Stefanie D. Krämer, Annette Braun, Christina Jakits-Deiser and Heidi Wunderli-Allenspach |
| 745-750 | Solid Lipid Nanoparticles in Lymph and Plasma After Duodenal Administration to Rats | Alessandro Bargoni, Roberta Cavalli, Otto Caputo, Anna Fundarò and Maria Rosa Gasco, et al. |
| 751-754 | Influence of Indocyanine Green on Plasma Disappearance and Biliary Excretion of a Synthetic Thrombin Inhibitor of the 3-Amidinophenyl-alanine Piperazide-type in Rats | Jörg Hauptmann and Jörg Stürzebecher |
| 755-761 | The Quantitative Analysis of Crystallinity Using FT-Raman Spectroscopy | Lynne S. Taylor and George Zografi |
| 762-767 | A Pragmatic Test of a Simple Calorimetric Method for Determining the Fragility of Some Amorphous Pharmaceutical Materials | Bruno C. Hancock, Chad R. Dalton, Michael J. Pikal and Sheri L. Shamblin |
| 768-775 | Effect of Spray Drying and Subsequent Processing Conditions on Residual Moisture Content and Physical/Biochemical Stability of Protein Inhalation Powders | Yuh-Fun Maa, Phuong-Anh Nguyen, James D. Andya, Nancy Dasovich and Theresa D. Sweeney, et al. |
| 776-782 | Synthesis and Physicochemical Properties of Lipophilic Polyamide Dendrimers | T. Sakthivel, Istvan Toth and Alexander T. Florence |
| 783-786 | Glow Discharge Plasma Deposition (GDPD) Technique for the Local Controlled Delivery of Hirudin from Biomaterials | Dae-Duk Kirn, Marc M. Takeno, Buddy D. Ratner and Thomas A. Horbett |
| 787-793 | Monitoring Microviscosity and Microacidity of the Albumin Microenvironment Inside Degrading Microparticles from Poly(lactide-co-glycolide) (PLG) or ABA-triblock Polymers Containing Hydrophobic Poly(lactide-co-glycolide) A Blocks and Hydrophilic Poly(ethyleneoxide) B Blocks | Karsten Mäder, Beate Bittner, Youxin Li, Wilko Wohlauf and Thomas Kissel |
| 794-798 | Physical Aging of Progesterone-Loaded Poly(D,L,-lactide-co-glycolide) Microspheres | V. Rosilio, M. Deyme, J. P. Benoit and G. Madelmont |
| 799-801 | Partition Behaviour of Drugs in Microemulsions Measured by Electrokinetic Chromatography | Y. Mrestani, R. H. H. Neubert and A. Krause |
| 802-805 | Drug Release from pH and Ionic Strength Responsive Poly(acrylic acid) Grafted Poly(vinylidenefluoride) Membrane Bags In Vitro | Kristiina Järvinen, Satu Åkerman, Bror Svarfvar, Tommy Tarvainen and Pasi Viinikka, et al. |
| 806-808 | Evaluation of the Adhesion Properties of Salbutamol Sulphate to Inhaler Materials | F. Podczeck |
| 809-812 | BOOK REVIEWS |
| 813-815 | Genetic Engineering of Protein-Based Polymers: Potential in Controlled Drug Delivery | Hamidreza Ghandehari and Joseph Cappello |
| 816-818 | Oligopeptide Transporters as Putative Therapeutic Targets for Cancer Cells | Randall J. Mrsny |
| 819-825 | Intracellular Phosphorylation of Zidovudine (ZDV) and Other Nucleoside Reverse Transcriptase Inhibitors (RTI) Used for Human Immunodeficiency Virus (HIV) Infection | Katrin Peter and John G. Gambertoglio |
| 826-834 | Recent Advances in Intestinal Macromolecular Drug Delivery via Receptor-Mediated Transport Pathways | Peter W. Swaan |
| 835-842 | The Molecular Mobility of Supercooled Amorphous Indomethacin as a Function of Temperature and Relative Humidity | Vlassios Andronis and George Zografi |
| 843-849 | Bond Cleavage Reactions in Solid Aqueous Carbohydrate Solutions | Lisette Streefland, Anthony D. Auffret and Felix Franks |
| 850-855 | Effects of Pluronic Block Copolymers on Drug Absorption in Caco-2 Cell Monolayers | Elena V. Batrakova, Huai-Yun Han, Valery Yu. Alakhov, Donald W. Miller and Alexander V. Kabanov |
| 856-862 | Jejunal Absorption and Metabolism of R/S-Verapamil in Humans | Rikard Sandström, Anders Karlsson, Lars Knutson and Hans Lennernäs |
| 863-869 | Interaction of a Self-Emulsifying Lipid Drug Delivery System with the Everted Rat Intestinal Mucosa as a Function of Droplet Size and Surface Charge | Tatyana Gershanik, Sharon Benzeno and Simon Benita |
| 870-876 | Nitric Oxide Donors Enhance Rectal Absorption of Macromolecules in Rabbits | Naoki Utoguchi, Yoshiteru Watanabe, Takako Shida and Mitsuo Matsumoto |
| 877-882 | Pharmacokinetics of the Transdermal Reservoir Membrane System Delivering β-Estradiol: In Vitro/In Vivo-Correlation | Uwe D. Rohr, Ralf Altenburger and Thomas Kissel |
| 883-888 | Skin Mini-Erosion Sampling Technique: Feasibility Study with Regard to Serial Glucose Measurement | Paul Svedman and Christer Svedman |
| 889-896 | In Vitro Dissolution Profile Comparison—Statistics and Analysis of the Similarity Factor, f2 | Vinod P. Shah, Yi Tsong, Pradeep Sathe and Jen-Pei Liu |
| 897-903 | Effect of Experimental Diabetes Mellitus and Arthritis on the Pharmacokinetics of Hydroxychloroquine Enantiomers in Rats | Jaber Emami, Franco M. Pasutto and Fakhreddin Jamali |
| 904-910 | Pharmacokinetics and Biodistribution of a Nucleotide-Based Thrombin Inhibitor in Rats | Larisa Reyderman and Salomon Stavchansky |
| 911-917 | Receptor Occupancy in Myocardium, Adrenal Cortex, and Brain by TH-142177, a Novel AT1 Receptor Antagonist in Rats, in Relation to Its Plasma Concentration and Hypotensive Effect | Yoshihisa Nozawa, Hidekazu Miyake, Shizuo Yamada and Ryohei Kimura |
| 918-924 | Non-Invasive Assessment and Control of Ultrasound-Mediated Membrane Permeabilization | Jin Liu, Thomas N. Lewis and Mark R. Prausnitz |
| 925-930 | Mechanistic Studies on Effervescent-Induced Permeability Enhancement | Jonathan D. Eichman and Joseph R. Robinson |
| 931-935 | Triazene Drug Metabolites: Part 15. Synthesis and Plasma Hydrolysis of Anticancer Triazenes Containing Amino Acid Carriers | Emilia Carvalho, Jim Iley, Maria de Jesus Perry and Eduarda Rosa |
| 936-943 | LC-UV-Electrospray-MS-MS Mass Spectrometry Analysis of Plant Constituents Inhibiting Xanthine Oxidase | Emanuele Gariboldi, Daniela Mascetti, Giovanni Galli, Pierre Caballion and Enrica Bosisio |
| 944-949 | Development of Infrared Imaging to Measure Thermogenesis in Cell Culture: Thermogenic Effects of Uncoupling Protein-2, Troglitazone, and β-Adrenoceptor Agonists | Mark A. Paulik, Richard G. Buckholz, Mary E. Lancaster, Walter S. Dallas and Emily A. Hull-Ryde, et al. |
| 950-952 | Intestinal Absorption of Ribavirin Is Preferentially Mediated by the Na+-Nucleoside Purine (Nl) Transporter | Shivakumar D. Patil, Leock Y. Ngo, Paul Glue and Jashvant D. Unadkat |
| 953-957 | Absorption of Propranolol in Humans Following Oral, Jejunal, and Heal Administration | Akshay Buch and William H. Barr |
| 958 | ERRATUM |
| 959-963 | Genomics and Drugs: Finding the Optimal Drug for the Right Patient | Wolfgang Sadée |
| 964-971 | MDCK Cell Cultures as an Epithelial In Vitro Model: Cytoskeleton and Tight Junctions as Indicators for the Definition of Age-Related Stages by Confocal Microscopy | Barbara Rothen-Rutishauser, Stefanie D. Krämer, Annette Braun, Maja Günthert and Heidi Wunderli-Allenspach |
| 972-978 | Predicting Drug Absorption from Molecular Surface Properties Based on Molecular Dynamics Simulations | Lene Hjorth Krarup, Inge Thøger Christensen, Lars Hovgaard and Sven Frokjaer |
| 979-983 | Dipeptide Uptake and Transport Characteristics in Rabbit Tracheal Epithelial Cell Layers Cultured at an Air Interface | Fumiyoshi Yamashita, Kwang-Jin Kim and Vincent H. L. Lee |
| 984-987 | lontophoretic Permselectivity of Mammalian Skin: Characterization of Hairless Mouse and Porcine Membrane Models | Asteria Luzardo-Alvarez, Mónica Rodríguez-Fernández, José Blanco-Méndez, Richard H. Guy and M. Begoña Delgado-Charro |
| 988-992 | In Vitro Cutaneous Disposition of a Topical Diclofenac Lotion in Human Skin: Effect of a Multi-Dose Regimen | Philip G. Hewitt, Nicholas Poblete, Ronald C. Wester, Howard I. Maibach and J. Zev Shainhouse |
| 993-1000 | Inhibition of P-Glycoprotein: Rapid Assessment of Its Implication in Blood-Brain Barrier Integrity and Drug Transport to the Brain by an In Vitro Model of the Blood-Brain Barrier | Laurence Fenart, Valeric Buée-Scherrer, Laurence Descamps, Christian Duhem and Marie-Gwenaëlle Poullain, et al. |
| 1001-1006 | Radioligand-Binding Assay Employing P-Glycoprotein-Overexpressing Cells: Testing Drug Affinities to the Secretory Intestinal Multidrug Transporter | Stephan Döppenschmitt, Hildegard Spahn-Langguth, Carl Gunnar Regårdh and Peter Langguth |
| 1007-1011 | Effect of Coadministered Uridine on Intestinal First-Pass Metabolism of 5′-Deoxy-5-Fluorouridine in Conscious Rats—An Evaluation by Method of Portal-Systemic Concentration Difference | Yoneichi Sawai, Kiyoshi Yamaoka and Terumichi Nakagawa |
| 1012-1018 | Evaluation of a Targeted Prodrug Strategy to Enhance Oral Absorption of Poorly Water-Soluble Compounds | O. Helen Chan, Heidi L. Schmid, Linda A. Stilgenbauer, William Howson and David C. Horwell, et al. |
| 1019-1025 | Low Swelling, Crosslinked Guar and Its Potential Use as Colon-Specific Drug Carrier | Irit Gliko-Kabir, Boris Yagen, Adel Penhasi and Abraham Rubinstein |
| 1026-1030 | The Effect of Cross-Linking on the In Vivo Disintegration of Hard Gelatin Capsules | J. Brown, N. Madit, E. T. Cole, I. R. Wilding and D. Cadé |
| 1031-1037 | Lectin-Mediated Drug Targeting: Preparation, Binding Characteristics, and Antiproliferative Activity of Wheat Germ Agglutinin Conjugated Doxorubicin on Caco-2 Cells | Michael Wirth, Andrea Fuchs, Michaela Wolf, Bernhard Ertl and Franz Gabor |
| 1038-1045 | Liposphere Local Anesthetic Timed-Release for Perineural Site Application | David B. Masters and Abraham J. Domb |
| 1046-1050 | Long-Circulating Nanopartides Bearing Heparin or Dextran Covalently Bound to Poly(Methyl Methacrylate) | Catherine Passirani, Gillian Barratt, Jean-Philippe Devissaguet and Denis Labarre |
| 1051-1055 | Combined Poly(isobutylcyanoacrylate) and Cyclodextrins Nanoparticles for Enhancing the Encapsulation of Lipophilic Drugs | Airton Monza da Silveira, Gilles Ponchel, Francis Puisieux and Dominique Duchêne |
| 1056-1062 | Preparation and Characterization of Nanocapsules from Preformed Polymers by a New Process Based on Emulsification-Diffusion Technique | David Quintanar-Guerrero, Eric Allémann, Eric Doelker and Hatem Fessi |
| 1063-1068 | Effects of Nitro-L-Arginine on Blood Pressure and Cardiac Index in Anesthetized Rats: A Pharmacokinetic-Pharmacodynamic Analysis | Mohammad A. Tabrizi-Fard and Ho-Leung Fung |
| 1069-1076 | Development of a New Quantitative Approach for the Isobolographic Assessment of the Convulsant Interaction Between Pefloxacin and Theophylline in Rats | Laurence M. Levasseur, Annie Delon, William R. Greco, Pascal Faury and Serge Bouquet, et al. |
| 1077-1084 | Evaluation of a Cmin and a Normalized Cmin Method for the Confirmation of Steady-State in Bioequivalence Studies | André J. Jackson |
| 1085-1089 | Lack of In Vivo/In Vitro Correlations for 50 mg and 250 mg Primidone Tablets | Marvin C. Meyer, Arthur B. Straughn, Ramakant M. Mhatre, Vinod P. Shah and R. L. Williams, et al. |
| 1090-1095 | Stability of Nonaqueous Suspension Formulations of Plasma Derived Factor IX and Recombinant Human Alpha Interferon at Elevated Temperatures | Victoria M. Knepp, Anna Muchnik, Sofia Oldmark and Larisa Kalashnikova |
| 1096-1102 | Chemical Pathways of Peptide Degradation: IX. Metal-Catalyzed Oxidation of Histidine in Model Peptides | Mehrnaz Khossravi and Ronald T. Borchardt |
| 1103-1110 | Improving Stability and Release Kinetics of Microencapsulated Tetanus Toxoid by Co-Encapsulation of Additives | Pål Johansen, Ying Men, Régine Audran, Giampietro Corradin and Hans P. Merkle, et al. |
| 1111-1116 | Enhanced Immunogenicity of Microencapsulated Tetanus Toxoid with Stabilizing Agents | Régine Audran, Ying Men, Pål Johansen, Bruno Gander and Giampietro Corradin |
| 1117-1121 | Characterisation of the Glass Transition of an Amorphous Drug Using Modulated DSC | Paul G. Royall, Duncan Q. M. Craig and Christopher Doherty |
| 1122-1130 | Compression Behavior of Orthorhombic Paracetamol | Etienne Joiris, Piera Di Martino, Christophe Berneron, Anne-Marie Guyot-Hermann and Jean-Claude Guyot |
| 1131-1136 | Viscoelastic Properties of Bioadhesive, Chlorhexidine-Containing Semi-Solids for Topical Application to the Oropharynx | David S. Jones, A. David Woolfson and Andrew F. Brown |
| 1137-1140 | Effect of Hydrogen Peroxide on the Viscosity of a Hydroxyethylcellulose-Based Gel | Terry Dahl, Gong-Xin He and Glenn Samuels |
| 1141-1144 | Quantification and Imaging of Mannitol Transport Through Caco-2 Cell Monolayers Using a Positron-Emitting Tracer | Lucia Lazorova, Johan Gråsjö, Per Artursson, Mats Bergström and Feng Wu, et al. |
| 1145-1147 | Nucleoside Transport in Isolated Human and Rhesus Choroid Plexus Tissue Slices | Carla B. Washington, Kathleen M. Giacomini and Claire M. Brett |
| 1149-1151 | News from the National Institute of General Medical Sciences (NIGMS) | Rochelle M. Long |
| 1152-1153 | The Use of Modulated Temperature DSC for the Study of Pharmaceutical Systems: Potential Uses and Limitations | Duncan Q. M. Craig and Paul G. Royall |
| 1154-1159 | 5′-Amino Acid Esters of Antiviral Nucleosides, Acyclovir, and AZT Are Absorbed by the Intestinal PEPT1 Peptide Transporter | Hyo-kyung Han, Remco L. A. de Vrueh, Julie K. Rhie, Kuang-Ming Y. Covitz and Philip L. Smith, et al. |
| 1160-1167 | Characterization of the Regional Intestinal Kinetics of Drug Efflux in Rat and Human Intestine and in Caco-2 Cells | Vijaya D. Makhey, Ailan Guo, Daniel A. Norris, Peidi Hu and Jiansheng Yan, et al. |
| 1168-1173 | Carrier Mechanisms Involved in the Transepithelial Transport of bis(POM)-PMEA and Its Metabolites Across Caco-2 Monolayers | P. Annaert, J. Van Gelder, L. Naesens, E. De Clercq and G. Van den Mooter, et al. |
| 1174-1181 | A Comparison of the Bioconversion Rates and the Caco-2 Cell Permeation Characteristics of Coumarin-Based Cyclic Prodrugs and Methylester-Based Linear Prodrugs of RGD Peptidomimetics | Gian P. Camenisch, Wei Wang, Binghe Wang and Ronald T. Borchardt |
| 1182-1188 | Transbuccal Delivery of Acyclovir: I. In Vitro Determination of Routes of Buccal Transport | Amir H. Shojaei, Bret Berner and Xiaoling Li |
| 1189-1195 | In Vivo Properties of an In Situ Forming Gel for Parenteral Delivery of Macromolecular Drugs | Rajashree Joshi, Vikram Arora, John P. Desjardins, Dennis Robinson and Kenneth J. Himmelstein, et al. |
| 1196-1201 | Guar Gum-Based Sustained Release Diltiazem | Syed A. Altaf, Karen Yu, Jagdish Parasrampuria and David R. Friend |
| 1202-1206 | Phase Behavior of Binary and Ternary Amorphous Mixtures Containing Indomethacin, Citric Acid, and PVP | Qun Lu and George Zografi |
| 1207-1214 | Particle Size Dependent Molecular Rearrangements During the Dehydration of Trehalose Dihydrate-In Situ FT-Raman Spectroscopy | Lynne S. Taylor, Adrian C. Williams and Peter York |
| 1215-1221 | Stabilization of Lactate Dehydrogenase Following Freeze-Thawing and Vacuum-Drying in the Presence of Trehalose and Borate | Danforth P. Miller, Rebeccah E. Anderson and Juan J. de Pablo |
| 1222-1232 | Fractal Analysis of Pharmaceutical Particles by Atomic Force Microscopy | Tonglei Li and Kinam Park |
| 1233-1237 | Process Variable Implications for Residual Solvent Removal and Polymer Morphology in the Formation of Gentamycin-Loaded Poly (L-lactide) Microparticles | Rick F. Falk and Theodore W. Randolph |
| 1238-1243 | Rate Control in Transdermal β-Estradiol Reservoir Membrane Systems: The Role of Membrane and Adhesive Layer | Ralf Altenburger, Uwe D. Rohr and Thomas Kissel |
| 1244-1249 | Tubular Localization and Tissue Distribution of Peptide Transporters in Rat Kidney | David E. Smith, Anna Pavlova, Urs V. Berger, Matthias A. Hediger and Tianxin Yang, et al. |
| 1250-1256 | Enantioselective Tissue Distribution of the Basic Drugs Disopyramide, Flecainide and Verapamil in Rats: Role of Plasma Protein and Tissue Phosphatidylserine Binding | Kazuhiko Hanada, Satoko Akimoto, Keiko Mitsui, Kiyoshi Mihara and Hiroyasu Ogata |
| 1257-1261 | Continuous Blood Withdrawal as a Rapid Screening Method for Determining Clearance and Oral Bioavailability in Rats | W. Griffith Humphreys, Mary T. Obermeier and Richard A. Morrison |
| 1262-1269 | Investigation of Absorption Kinetics by the Phase Plane Method | Aristides Dokoumetzidis and Panos Macheras |
| 1270-1274 | Potential of Immobilized Artificial Membranes for Predicting Drug Penetration Across the Blood−Brain Barrier | Andreas Reichel and David J. Begley |
| 1275-1280 | Evaluation of Cytotoxicity of Various Ophthalmic Drugs, Eye Drop Excipients and Cyclodextrins in an Immortalized Human Corneal Epithelial Cell Line | Paula Saarinen-Savolainen, Tomi Järvinen, Kaoru Araki-Sasaki, Hitoshi Watanabe and Arto Urtti |
| 1281-1285 | Effect of Pancreatico-Biliary Secretions and GI Transit Time on the Absorption and Pharmacokinetic Profile of Ranitidine in Humans | Kellie S. Reynolds, Min H. Song, William D. Heizer, Charles B. Burns and Domenic A. Sica, et al. |
| 1286-1291 | Single-dose Pharmacokinetics of Rifapentine in Elderly Men | Anther C. F. Keung, Mark G. Eller and Scott J. Weir |
| 1292-1299 | Metrics Comparing Simulated Early Concentration Profiles for the Determination of Bioequivalence | Laszlo Endrenyi, Ferenc Csizmadia, Laszlo Tothfalusi and Mei-Ling Chen |
| 1300-1304 | Biexponential Decomposition of a Neuraminidase Inhibitor Prodrug (GS-4104) in Aqueous Solution | Reza Oliyai, Lung-Chi Yuan, Terrence C. Dahl, S. Swaminathan and Ke-Yu Wang, et al. |
| 1305-1309 | Adsorptive-Mediated Transcytosis of a Synthetic Basic Peptide, 001-C8 in Caco-2 Cells | Yoshimichi Sai, Masahiro Kajita, Ikumi Tamai, Jun Wakama and Tateaki Wakamiya, et al. |
| 1310-1313 | Considerations on the Potentiometric Log P Determination | Stefanie D. Krämer, Jean-Claude Gautier and Philippe Saudemon |
| 1314-1316 | Assessment of Regional Differences in Intestinal Fluid Movement in the Rat Using a Modified In Situ Single Pass Perfusion Model | Araz A. Raoof, Jackie Butler and John G. Devane |
| 1317-1319 | BOOK REVIEWS |
| 1320 | ERRATUM |
| 1321-1325 | Individual Bioequivalence: Attractive in Principle, Difficult in Practice | Laszlo Endrenyi, Gordon L. Amidon, Kamal K. Midha and Jerome P. Skelly |
| 1326-1331 | Chitosan and Its Use as a Pharmaceutical Excipient | Lisbeth Ilium |
| 1332-1339 | Chitosan-Based Vector/DNA Complexes for Gene Delivery: Biophysical Characteristics and Transfection Ability | Patrick Erbacher, Shaomin Zou, Thierry Bettinger, Anne-Marie Steffan and Jean-Serge Remy |
| 1340-1347 | Target Specific Optimization of Cationic Lipid-Based Systems for Pulmonary Gene Therapy | Deepa Deshpande, Paul Blezinger, Ravi Pillai, John Duguid and Bruce Freimark, et al. |
| 1348-1355 | Beta Cyclodextrins Enhance Adenoviral-Mediated Gene Delivery to the Intestine | Maria A. Croyle, Blake J. Roessler, Cheng-Pang Hsu, Rong Sun and Gordon L. Amidon |
| 1356-1363 | Characterization and In Vivo Testing of a Heterogeneous Cationic Lipid-DNA Formulation | Janet G. Smith, Todd Wedeking, John H. Vernachio, Hollis Way and Ralph W. Niven |
| 1364-1369 | Liposomes Dispersed Within a Thermosensitive Gel: A New Dosage Form for Ocular Delivery of Oligonucleotides | Amélie Bochot, Elias Fattal, Annette Gulik, Guy Couarraze and Patrick Couvreur |
| 1370-1375 | Prediction of Intestinal Drug Absorption Properties by Three-Dimensional Solubility Parameters | Jörg Breitkreutz |
| 1376-1381 | Overexpression of Human Intestinal Oligopeptide Transporter in Mammalian Cells via Adenoviral Transduction | Cheng-Pang Hsu, John M. Hilfinger, Elke Walter, Hans P. Merkle and Blake J. Roessler, et al. |
| 1382-1386 | Cellular Uptake Mechanism of Amino Acid Ester Prodrugs in Caco-2/hPEPT1 Cells Overexpressing a Human Peptide Transporter | Hyo-kyung Han, Doo-Man Oh and Gordon L. Amidon |
| 1387-1392 | Permeability Characteristics of Tetragastrins Across Intestinal Membranes Using the Caco-2 Monolayer System: Comparison Between Acylation and Application of Protease Inhibitors | Takuya Fujita, Iichiro Kawahara, Ying-shu Quan, Koji Hattori and Kayo Takenaka, et al. |
| 1393-1400 | Transport of Proteolytic Enzymes Across Caco-2 Cell Monolayers | Udo Bock, Corinna Kolac, Gerrit Borchard, Kerstin Koch and Roland Fuchs, et al. |
| 1401-1406 | Hydrophobicity of HIV Protease Inhibitors by Immobilized Artificial Membrane Chromatography: Application and Significance to Drug Transport | Barbra H. Stewart, Francis Y. Chung, Bradley Tait, C. John and O. Helen Chan |
| 1407-1413 | Mechanisms of Liposomes/Water Partitioning of (p-Methylbenzyl)alkylamines | Roberta Fruttero, Giulia Caron, Elisa Fornatto, Donatella Boschi and Giuseppe Ermondi, et al. |
| 1414-1418 | Permeability of Articular Cartilage to Matrix Metalloprotease Inhibitors | Sean X. Peng, Edward C. VonBargen, David M. Bornes and Stanislaw Pikul |
| 1419-1424 | Prodrugs of Gestodene for Matrix-Type Transdermal Drug Delivery Systems | Ralph Lipp, Henry Laurent, Clemens Günther, Jutta Riedl and Peter Esperling, et al. |
| 1425-1433 | Characterization of Three Crystalline Forms (VIII, XI, and XII) and the Amorphous Form (V) of Delavirdine Mesylate Using 13C CP/MAS NMR | Ping Gaou |
| 1434-1441 | Self-Association Properties of Monomeric Insulin Analogs Under Formulation Conditions | Jane P. Richards, Mary P. Stickelmeyer, David B. Flora, Ronald E. Chance and Bruce H. Frank, et al. |
| 1442-1448 | Effect of Gelation on the Chemical Stability and Conformation of Leuprolide | Mandy M. Tan, Cynthia A. Corley and Cynthia L. Stevenson |
| 1449-1455 | Degradation Kinetics of Three Gonadorelin Analogues: Developing a Method for Calculating Epimerization Parameters | Marnix A. Hoitink, Jos H. Beijnen, Marcel U. S. Boschma, Auke Bult and Oeds A. G. J. van der Houwen, et al. |
| 1456-1462 | Chemical Degradation Kinetics of Recombinant Hirudin (HVI) in Aqueous Solution: Effect of pH | Ursula Gietz, Ruth Alder, Peter Langguth, Tudor Arvinte and Hans P. Merkle |
| 1463-1468 | Automated Covariate Model Building Within NONMEM | E. Niclas Jonsson and Mats O. Karlsson |
| 1469-1473 | Correction for Non-Ideal Tracer Pharmacokinetic Disposition by Disposition Decomposition Analysis (DDA) | P. Veng-Pedersen, S. S. Hong, J. A. Widness and R. L. Schmidt |
| 1474-1479 | Correlation of Plasma Clearance of 54 Extensively Metabolized Drugs Between Humans and Rats: Mean Allometric Coefficient of 0.66 | Win L. Chiou, Gabriel Robbie, Sang Mock Chung, Ta-Chen Wu and Chien Ma |
| 1480-1484 | Enzymatic Degradation of Luteinizing Hormone Releasing Hormone (LHRH)/[D-Ala6]-LHRH in Lung Pneumocytes | Xiaodong Yang, Yon Rojanasakul, Liying Wang, Jane Y. C. Ma and Joseph K. H. Ma |
| 1485-1489 | The Roles of Depot Injection Sites and Proximal Lymph Nodes in the Presystemic Absorption of Fluphenazine Decanoate and Fluphenazine: Ex Vivo Experiments in Rats | Jiang-ping Luo, John W. Hubbard and Kamal K. Midha |
| 1490-1494 | Correlating Partitioning and Caco-2 Cell Permeability of Structurally Diverse Small Molecular Weight Compounds | Mehran Yazdanian, Susan L. Glynn, James L. Wright and Amale Hawi |
| 1495-1498 | Cellular Uptake Study of Biodegradable Nanoparticles in Vascular Smooth Muscle Cells | Hearan Suh, Byeongmoon Jeong, Feng Liu and Sung Wan Kim |
| 1499-1502 | Effect of Neutral Endopeptidase Inhibition on the Natriuresis and Renal Clearance of Atrial Natriuretic Peptide in Perfused Rat Kidney | Masayuki Yamaguchi, Yukiya Hashimoto, Hiroshi Itoh, Kazuwa Nakao and Ken-ichi Inui |
| 1503-1506 | An Interview with a Distinguished Pharmaceutical Scientist: Jessie L.-S. Au. |
| 1507-1519 | A New Look at Lipid-Membrane Structure in Relation to Drug Research | Ole G. Mouritsen and Kent Jørgensen |
| 1520-1524 | Characterization of P-glycoprotein Mediated Transport of K02, a Novel Vinylsulfone Peptidomimetic Cysteine Protease Inhibitor, Across MDR1-MDCK and Caco-2 Cell Monolayers | Yuanchao Zhang and Leslie Z. Benet |
| 1525-1532 | Effects of Pluronic P85 Unimers and Micelles on Drug Permeability in Polarized BBMEC and Caco-2 Cells | Elena V. Batrakova, Huai-Yun Han, Donald W. Miller and Alexander V. Kabanov |
| 1533-1539 | Partial Maintenance of Taurocholate Uptake by Adult Rat Hepatocytes Cultured in a Collagen Sandwich Configuration | Xingrong Liu, Kim L. R. Brouwer, Liang-Sheng L. Gan, Kenneth R. Brouwer and Bruno Stieger, et al. |
| 1540-1545 | Folate-Mediated Targeting of Antisense Oligodeoxynucleotides to Ovarian Cancer Cells | Song Li, Hemant M. Deshmukh and Leaf Huang |
| 1546-1551 | Proliferation Indices as Molecular Pharmacodynamic Endpoints in Evaluation of Anticancer Drug Effect in Human Solid Tumors | Jean R. Weaver, Yuebo Gan and Jessie L.-S. Au |
| 1552-1556 | Accumulation of Protein-Loaded Long-Circulating Micelles and Liposomes in Subcutaneous Lewis Lung Carcinoma in Mice | Volkmar Weissig, Kathleen R. Whiteman and Vladimir P. Torchilin |
| 1557-1561 | Effects of Interleukin-1 Receptor Antagonist in a Slow-Release Hylan Vehicle on Rat Type II Collagen Arthritis | Alison Bendele, Tracy McAbee, Melissa Woodward, Jon Scherrer and Dave Collins, et al. |
| 1562-1568 | Design and Evaluation of an Osmotic Pump Tablet (OPT) for Prednisolone, a Poorly Water Soluble Drug, Using (SBE)7m-β-CD | Kazuto Okimoto, Masatoshi Miyake, Norio Ohnishi, Roger A. Rajewski and Valentine J. Stella, et al. |
| 1569-1578 | Epidermal Iontophoresis: I. Development of the Ionic Mobility-Pore Model | Michael S. Roberts, Pamela M. Lai and Yuri G. Anissimov |
| 1579-1588 | Epidermal Iontophoresis: II. Application of the Ionic Mobility-Pore Model to the Transport of Local Anesthetics | Pamela M. Lai and Michael S. Roberts |
| 1589-1595 | In Vivo Bioavailability and Metabolism of Topical Diclofenac Lotion in Human Volunteers | Xiaoying Hui, Philip G. Hewitt, Nicholas Poblete, Howard I. Maibach and J. Zev Shainhouse, et al. |
| 1596-1602 | Localization of a FITC-Labeled Phosphorothioate Oligodeoxynucleotide in the Skin After Topical Delivery by Iontophoresis and Electroporation | Vincent Regnier and Veronique Préat |
| 1603-1608 | The Effect of High Dose Endotoxin on CYP3A2 Expression in the Rat | Amy L. Roe, Graham Warren, Guoqiang Hou, Georgette Howard and Steven I. Shedlofsky, et al. |
| 1609-1613 | Effects of Intestinal and Hepatic Metabolism on the Bioavailability of Tacrolimus in Rats | Yukiya Hashimoto, Hiroaki Sasa, Masahiro Shimomura and Ken-ichi Inui |
| 1614-1620 | Absorption, Metabolism, and Disposition of [14C]SDZ ENA 713, an Acetylcholinesterase Inhibitor, in Minipigs Following Oral, Intravenous, and Dermal Administration | Francis L. S. Tse and Robert Laplanche |
| 1621-1629 | Truncated Area Under the Curve as a Measure of Relative Extent of Bioavailability: Evaluation Using Experimental Data and Monte Carlo Simulations | Jacques Gaudreault, Diane Potvin, Jean Lavigne and Richard L. Lalonde |
| 1630-1636 | Elucidation of Human Amphotericin B Pharmacokinetics: Identification of a New Potential Factor Affecting Interspecies Pharmacokinetic Scaling | Gabriel Robbie and Win L. Chiou |
| 1637-1639 | Dodecylmaltoside-Mediated Nasal and Ocular Absorption of Lyspro-Insulin: Independence of Surfactant Action from Multimer Dissociation | Dennis J. Pillion, Susan Hosmer and Elias Meezan |
| 1640-1642 | Ovariectomy Results in Lower Plasma Haloperidol Levels in Rats Following Chronic Administration | Jeffrey W. Grimm, Manickam Aravagiri and Ronald E. See |
| 1643-1646 | A Modified Equilibrium Dialysis Technique for Measuring Plasma Protein Binding: Experimental Evaluation with Diazepam and Nortriptyline | Hsiao-Hui Chow, Soo Peang Khor, Hui-Chih Lee and Michael Mayersohn |
| 1647-1648 | News from the National Institute of General Medical Sciences (NIGMS) | Rochelle M. Long |
| 1649-1651 | Estimating the Critical Molecular Mobility Temperature (TK) of Amorphous Pharmaceuticals | Bruno C. Hancock, Karen Christensen and Sheri L. Shamblin |
| 1652-1656 | Antibodies as Carrier Proteins | Bruce N. Rehlaender and Moo J. Cho |
| 1657-1665 | BBB Transport and P-glycoprotein Functionality Using MDR1A (-/-) and Wild-Type Mice. Total Brain Versus Microdialysis Concentration Profiles of Rhodamine-123 | Elizabeth C. M. de Lange, Gertjan de Bock, Alfred H. Schinkel, Albertus G. de Boer and Douwe D. Breimer |
| 1666-1672 | In Vitro and In Situ Absorption of SDZ-RAD Using a Human Intestinal Cell Line (Caco-2) and a Single Pass Perfusion Model in Rats: Comparison with Rapamycin | Andrew Crowe and Michel Lemaire |
| 1673-1679 | Methodological Aspects of the Use of a Calibrator in In Vivo Microdialysis–Further Development of the Retrodialysis Method | M. René Bouw and Margareta Hammarlund-Udenaes |
| 1680-1683 | Effect of Ultrasound Application on Skin Metabolism of Prednisolone 21-Acetate | Tomohiro Hikima, Yoshiaki Hirai and Kakuji Tojo |
| 1684-1689 | Biotransformation of Estradiol in the Human Keratinocyte Cell Line HaCaT: Metabolism Kinetics and the Inhibitory Effect of Ethanol | Ralf Altenburger and Thomas Kissel |
| 1690-1695 | Scavenging of the One-Electron Reduction Product from Nisoldipine with Relevant Thiols: Electrochemical and EPR Spectroscopic Evidences | Luis J. Núñez-Vergara, G. Díaz-Araya, C. Olea-Azar, A. M. Atria and S. Bollo-Dragnic, et al. |
| 1696-1701 | Co-Administration of a Water-Soluble Polymer Increases the Usefulness of Cyclodextrins in Solid Oral Dosage Forms | Jouko Savolainen, Kristiina Järvinen, Hannu Taipale, Pekka Jarho and Thorsteinn Loftsson, et al. |
| 1702-1707 | Isothermal and Nonisothermal Decomposition of Thymopentin and Its Analogs in Aqueous Solution | Mu-Lan Lee and Salomon Stavchansky |
| 1708-1713 | Microencapsulation of Hepatitis B Core Antigen for Vaccine Preparation | Takahiro Uchida, Kouichi Shiosaki, Yoichi Nakada, Katsuhiko Fukada and Yasuyuki Eda, et al. |
| 1714-1720 | Quantitative Determination of the Extent of Neutralization of Carboxylic Acid Functionality in Carbopol® 974P NF by Diffuse Reflectance Fourier Transform Infrared Spectrometry Using Kubelka-Munk Function | Rong-Hwei Juang and David E. Storey |
| 1721-1726 | Visualization of PEO-PBLA-Pyrene Polymeric Micelles by Atomic Force Microscopy | Jiahorng Liaw, Takao Aoyagi, Kazunori Kataoka, Yasuhisa Sakurai and Teruo Okano |
| 1727-1736 | Can the Organization of a Binary Mix Be Predicted from the Surface Energy, Cohesion Parameter and Particle Size of Its Components? | J. Barra, F. Lescure, F. Falson-Rieg and E. Doelker |
| 1737-1742 | Enhanced Encapsulation of Amphotericin B into Liposomes by Complex Formation with Polyethylene Glycol Derivatives | Kunikazu Moribe, Eitaro Tanaka, Kazuo Maruyama and Motoharu Iwatsuru |
| 1743-1747 | Ultrasonic Nebulization of Cationic Lipid-Based Gene Delivery Systems for Airway Administration | Ravi Pillai, Karel Petrak, Paul Blezinger, Deepa Deshpande and Valarie Florack, et al. |
| 1748-1752 | A New Powder Design Method to Improve Inhalation Efficiency of Pranlukast Hydrate Dry Powder Aerosols by Surface Modification with Hydroxypropylmethylcellulose Phthalate Nanospheres | Yoshiaki Kawashima, Takanori Serigano, Tomoaki Hino, Hiromitsu Yamamoto and Hirofumi Takeuchi |
| 1753-1759 | Surface-modified Antiasthmatic Dry Powder Aerosols Inhaled Intratracheally Reduce the Pharmacologically Effective Dose | Yoshiaki Kawashima, Takanori Serigano, Tomoaki Hino, Hiromitsu Yamamoto and Hirofumi Takeuchi |
| 1760-1766 | Antiproliferative and Cytotoxic Effects of Geldanamycin, Cytochalasin E, Suramin and Thiacetazone in Human Prostate Xenograft Tumor Histocultures | Yuebo Gan, Jessie L.-S. Au, Jie Lu and M. Guillaume Wientjes |
| 1767-1774 | Effects of Cholecystokinin Octapeptide on a Pancreatic Acinar Carcinoma in the Rat | Amor Hajri and Christiane Damgé |
| 1775-1781 | Altered Tissue Distribution and Elimination of Amikacin Encapsulated in Unilamellar, Low-Clearance Liposomes (MiKasome®) | Robert M. Fielding, Ramilla O. Lewis and Lotus Moon-McDermott |
| 1782-1786 | Estimation of Oral Bioavailability of a Long Half-Life Drug in Healthy Subjects | Amarnath Sharma, Peter H. Slugg, Janis L. Hammett and William J. Jusko |
| 1787-1791 | The Relative Bioavailability and In Vivo-In Vitro Correlations for Four Marketed Carbamazepine Tablets | Marvin C. Meyer, Arthur B. Straughn, Ramakant M. Mhatre, Vinod P. Shah and Roger L. Williams, et al. |
| 1792-1795 | Linear Correlation of the Fraction of Oral Dose Absorbed of 64 Drugs Between Humans and Rats | Win L. Chiou and Abhijit Barve |
| 1796-1798 | Considerations in the Attainment of Steady State: Aggregate vs. Individual Assessment | Walter W. Hauck, Thomas N. Tozer, Sharon Anderson and Frédéric Y. Bois |
| 1799-1802 | Stability of UC-781, in Intestinal Mucosal Homogenates of the Rat, Rabbit, and Pig | Guy Van den Mooter, Geert Stas, Festo Damian, Lieve Naesens and Jan Balzarini, et al. |
| 1803-1806 | BOOK REVIEWS |
| 1807 | News from the National Institute of General Medical Sciences (NIGMS) | Peter C. Preusch |
| 1808-1815 | Improved Folding Yields of a Model Protein Using Protein Disulfide Isomerase | Chengan Du, Jennifer M. Ye and Janet L. Wolfe |
| 1816-1821 | A Solid-State NMR Study of Protein Hydration and Stability | F. Separovic, Y. H. Lam, X. Ke and H.-K. Chan |
| 1822-1827 | PEGylation Prevents the N-Terminal Degradation of Megakaryocyte Growth and Development Factor | Patricia I. Guerra, Christine Acklin, Andrew A. Kosky, Janice M. Davis and Michael J. Treuheit, et al. |
| 1828-1834 | Enthalpy Relaxation in Binary Amorphous Mixtures Containing Sucrose | Sheri L. Shamblin and George Zografi |
| 1835-1843 | Supercritical Fluid Processing of Materials from Aqueous Solutions: The Application of SEDS to Lactose as a Model Substance | Srinivas Palakodaty, Peter York and John Pritchard |
| 1844-1850 | Development of Novel Chitosan Derivatives as Micellar Carriers of Taxol | Akio Miwa, Atsuo Ishibe, Mari Nakano, Tomohiro Yamahira and Shigeru Itai, et al. |
| 1851-1856 | Transfected Rat cMOAT Is Functionally Expressed on the Apical Membrane in Madin-Darby Canine Kidney (MDCK) Cells | Setsuo Kinoshita, Hiroshi Suzuki, Kousei Ito, Kazuhiko Kume and Takao Shimizu, et al. |
| 1857-1862 | Mechanism of Transport Enhancement of LHRH Through Porcine Epidermis by Terpenes and Iontophoresis: Permeability and Lipid Extraction Studies | Kuljit S. Bhatia and Jagdish Singh |
| 1863-1868 | In Vitro Human Epidermal and Polyethylene Membrane Penetration and Retention of the Sunscreen Benzophenone-3 from a Range of Solvents | Ruoying Jiang, Heather A. E. Benson, Sheree E. Cross and Michael S. Roberts |
| 1869-1875 | Use of the InteliSite® Capsule to Study Ranitidine Absorption from Various Sites Within the Human Intestinal Tract | Yazdi K. Pithavala, William D. Heizer, Alan F. Parr, Robin L. O'Connor-Semmes and Kim L. R. Brouwer |
| 1876-1881 | Intestinal Transport of Gentamicin with a Novel, Glycosteroid Drug Transport Agent | Helena R. Axelrod, Jae Seung Kim, Clifford B. Longley, Elke Lipka and Gordon L. Amidon, et al. |
| 1882-1887 | Ocular Absorption of Pz-Peptide and Its Effect on the Ocular and Systemic Pharmacokinetics of Topically Applied Drugs in the Rabbit | Youn Bok Chung, Kun Han, Akio Nishiura and Vincent H. L. Lee |
| 1888-1894 | Pharmacokinetic and Pharmacoimmunodynamic Interactions Between Prednisolone and Sirolimus in Rabbits | Geraldine M. Ferron and William J. Jusko |
| 1895-1901 | Pharmacokinetics and Leukocyte Responses of Recombinant Human Interleukin-10 | Elaine Radwanski, Abhijit Chakraborty, Scott Van Wart, Richard D. Huhn and David L. Cutler, et al. |
| 1902-1906 | Determination of Continuous Changes in the Gel Layer Thickness of Poly(ethylene oxide) and HPMC Tablets Undergoing Hydration: A Texture Analysis Study | Libo Yang, Boine Johnson and Reza Fassihi |
| 1907-1910 | Effect of ZTTA, a Prolyl Endopeptidase Inhibitor, on Memory Impairment in a Passive Avoidance Test of Rats with Basal Forebrain Lesions | Yoshiyuki Shishido, Masayoshi Furushiro, Shuichi Tanabe, Akira Taniguchi and Shusuke Hashimoto, et al. |
| 1911 | ERRATUM |
| 1912-1914 | Reviewers for Pharmaceutical Research November 1997 Through October 1998 |
| 1915-1919 | Author Index to Volume 15 (1998) |
| 1920-1924 | Subject Index to Volume 15 (1998) |
| 1-6 | Artificial Neural Network as a Novel Method to Optimize Pharmaceutical Formulations | Kozo Takayama, Mikito Fujikawa and Tsuneji Nagai |
| 7-15 | Coumarinic Acid-Based Cyclic Prodrugs of Opioid Peptides that Exhibit Metabolic Stability to Peptidases and Excellent Cellular Permeability | Olafur S. Gudmundsson, Giovanni M. Pauletti, Wei Wang, Daxian Shan and Huijuan Zhang, et al. |
| 16-23 | Phenylpropionic Acid-Based Cyclic Prodrugs of Opioid Peptides that Exhibit Metabolic Stability to Peptidases and Excellent Cellular Permeation | Olafur S. Gudmundsson, Kalpana Nimkar, Sanjeev Gangwar, Teruna Siahaan and Ronald T. Borchardt |
| 24-29 | Acyloxyalkoxy-Based Cyclic Prodrugs of Opioid Peptides: Evaluation of the Chemical and Enzymatic Stability as Well as Their Transport Properties Across Caco-2 Cell Monolayers | Annette Bak, Olafur S. Gudmundsson, Gitte J. Friis, Teruna J. Siahaan and Ronald T. Borchardt |
| 30-36 | Submicron Cationic Emulsions as a New Delivery System for Oligonucleotides | H. Teixeira, C. Dubernet, F. Puisieux, S. Benita and P. Couvreur |
| 37-41 | Spleen Capture of Nanoparticles: Influence of Animal Species and Surface Characteristics | Marina Demoy, Jean-Paul Andreux, Colette Weingarten, Bruno Gouritin and Valérie Guilloux, et al. |
| 42-45 | Penetration Studies of Clotrimazole from Semisolid Formulation Using Step-Scan FT-IR Photoacoustic Spectroscopy | Anja Schendzielorz, Bui Duc Hanh, Reinhard H. H. Neubert and Siegfried Wartewig |
| 46-54 | Lateral lontophoretic Solute Transport in Skin | Pamela M. Lai, Yuri G. Anissimov and Michael S. Roberts |
| 55-61 | Intestinal Transport of β-Lactam Antibiotics: Analysis of the Affinity at the H+/Peptide Symporter (PEPT1), the Uptake into Caco-2 Cell Monolayers and the Transepithelial Flux | Beate Bretschneider, Matthias Brandsch and Reinhard Neubert |
| 62-68 | Structure-Transport Relationship for the Intestinal Small-Peptide Carrier: Is the Carbonyl Group of the Peptide Bond Relevant for Transport? | Ronald G. Schoenmakers, Marco C. Stehouwer and Josef J. Tukker |
| 69-73 | Intestinal Absorption of Acyclovir β-Glucoside: Comparative Study with Acyclovir, Guanosine, and Kinetin β-Glucoside | Takashi Mizuma, Satoshi Masubuchi and Shoji Awazu |
| 74-79 | Inhibition of Binding of an Enzymatically Stable Thrombin Inhibitor to Lumenal Proteases as an Additional Mechanism of Intestinal Absorption Enhancement | M. Sjöström, L. Lindfors and A.-L. Ungell |
| 80-86 | In Vitro and In Vivo Evaluation of the Enhancing Activity of Glycyrrhizin on the Intestinal Absorption of Drugs | Teruko Imai, Michinori Sakai, Hiroshi Ohtake, Hidekazu Azuma and Masaki Otagiri |
| 87-91 | Heterogeneous Tube Model for the Study of Small Intestinal Transit Flow | Alkiviadis Kalampokis, Panos Argyrakis and Panos Macheras |
| 92-96 | The Effect of Oleic Acid on the Human Ileal Brake and Its Implications for Small Intestinal Transit of Tablet Formulations | Clair L. Dobson, Stanley S. Davis, Sushil Chauhan, Robert A. Sparrow and Ian R. Wilding |
| 97-102 | Surface Activity and Concentration Dependent Intestinal Permeability in the Rat | Anders Lindahl, Bengt Persson, Anna-Lena Ungell and Hans Lennernäs |
| 103-109 | Analysis of Nonlinear Hepatic Clearance of a Cyclopentapeptide, BQ-123, with the Multiple Indicator Dilution Method Using the Dispersion Model | Akihiro Hisaka, Tatsuji Nakamura and Yuichi Sugiyama |
| 110-116 | Determination of the Rate-Limiting Step in the Hepatic Elimination of YM796 by Isolated Rat Hepatocytes | Takafumi Iwatsubo, Hiroshi Suzuki and Yuichi Sugiyama |
| 117-122 | Pharmacokinetics and Biologic Activity of the Novel Mast Cell Inhibitor, 4-(3′-Hydroxyphenyl)-amino-6,7-dimethoxyquinazoline in Mice | Chun-Lin Chen, Ravi Malaviya, Christopher Navara, Hao Chen and Brian Bechard, et al. |
| 123-129 | Dependency of Gastrointestinal Toxicity on Release Rate of Tiaprofenic Acid: A Novel Pharmacokinetic-Pharmacodynamic Model | Majid Vakily, Farhad Khorasheh and Fakhreddin Jamali |
| 130-134 | Use of Truncated Areas to Measure Extent of Drug Absorption in Bioequivalence Studies: Effects of Drug Absorption Rate and Elimination Rate Variability on this Metric | Jahnavi Kharidia, Andre J. Jackson and Larry A. Ouderkirk |
| 135-140 | The Effect of Excipients on the Molecular Mobility of Lyophilized Formulations, as Measured by Glass Transition Temperature and NMR Relaxation-Based Critical Mobility Temperature | Sumie Yoshioka, Yukio Aso and Shigeo Kojima |
| 141-147 | Molecular Mechanisms of the Adsorption of a Model Protein (Human Serum Albumin) on Poly(Methylidene Malonate 2.1.2) Nanoparticles | Yoléne Bousquet, Pieter J. Swart, Nathalie Schmitt-Colin, Florence Velge-Roussel and Mirjam E. Kuipers, et al. |
| 148-154 | Novel Bioresorbable and Bioeliminable Surfactants for Microsphere Preparation | P. Bouillot, V. Babak and E. Dellacherie |
| 155-160 | A Novel Formulation of VIP in Sterically Stabilized Micelles Amplifies Vasodilation In Vivo | Hayat Önyüksel, Hiroyuki Ikezaki, Manisha Patel, Xiao-pei Gao and Israel Rubinstein |
| 161-164 | Electrochemical Generation and Interaction Study of the Nitro Radical Anion from Nimesulide | J. A. Squella, P. Gonzalez, S. Bollo and L. J. Núñez-Vergara |
| 165-169 | A Comparison of Step-Gradient and Sequential Density Ultracentrifugation and the Use of Lipoprotein Deficient Plasma Controls in Determining the Plasma Lipoprotein Distribution of Lipid-Associated Nystatin and Cyclosporine | Kishor M. Wasan, Shawn M. Cassidy, Manisha Ramaswamy, Allison Kennedy and Frank W. Strobel, et al. |
| 170-173 | Accuracy and Precision of Pharmacodynamic Exponent | Nancy J. Millenbaugh, M. Guillaume Wientjes and Jessie L.-S. Au |
| 175 | Letter to the Editor | Gordon L. Amidon and Charles R. Walgreen |
| 176-185 | Modeling of Pharmacokinetic/Pharmacodynamic (PK/PD) Relationships: Concepts and Perspectives | Hartmut Derendorf and Bernd Meibohm |
| 186-190 | Subject-by-Formulation Interaction in Determinations of Individual Bioequivalence: Bias and Prevalence | Laszlo Endrenyi and Laszlo Tothfalusi |
| 191-197 | The Effect of Hormones on the Expression of Five Isoforms of UDP-Glucuronosyltransferase in Primary Cultures of Rat Hepatocytes | Van Q. Li, David A. Prentice, Monique L. Howard, Maurice L. Mashford and Paul V. Desmond |
| 198-204 | Liposomes with Incorporated MHC Class Il/Peptide Complexes as Antigen Presenting Vesicles for Specific T Cell Activation | Annemiek J. M. L. van Rensen, Marca H. M. Wauben, Mayken C. Grosfeld-Stulemeyer, Willem van Eden and Daan J. A. Crommelin |
| 205-212 | Prediction of Membrane Permeability to Peptides from Calculated Dynamic Molecular Surface Properties | Patric Stenberg, Kristina Luthman and Per Artursson |
| 213-220 | Permeation of PEO-PBLA-FITC Polymeric Micelles in Aortic Endothelial Cells | Jiahorng Liaw, Takao Aoyagi, Kazunori Kataoka, Yasuhisa Sakurai and Teruo Okano |
| 221-224 | Net Secretion of Furosemide Is Subject to Indomethacin Inhibition, as Observed in Caco-2 Monolayers and Excised Rat Jejunum | Shawn D. Flanagan and Leslie Z. Benet |
| 225-231 | Effects of Intestinal CYP3A4 and P-Glycoprotein on Oral Drug Absorption—Theoretical Approach | Kiyomi Ito, Hiroyuki Kusuhara and Yuichi Sugiyama |
| 232-240 | Intracranial Delivery of Recombinant Nerve Growth Factor: Release Kinetics and Protein Distribution for Three Delivery Systems | W. Mark Saltzman, Michele W. Mak, Melissa J. Mahoney, Eileen T. Duenas and Jeffrey L. Cleland |
| 241-248 | The Acidic Microclimate in Poly(lactide-co-glycolide) Microspheres Stabilizes Camptothecins | Anna Shenderova, Thomas G. Burke and Steven P. Schwendeman |
| 249-254 | Protein Inhalation Powders: Spray Drying vs Spray Freeze Drying | Yuh-Fun Maa, Phuong-Anh Nguyen, Theresa Sweeney, Steven J. Shire and Chung C. Hsu |
| 255-260 | A Polysorbate-Based Non-Ionic Surfactant Can Modulate Loading and Release of β-Lactoglobulin Entrapped in Multiphase Poly(DL-Lactide-co-glycolide) Microspheres | Judith Rojas, Huguette Pinto-Aiphandary, Eliana Leo, Sophie Pecquet and Patrick Couvreur, et al. |
| 261-265 | Influence of Crystal Habit on Trimethoprim Suspension Formulation | Ashok K. Tiwary and Gopal M. Panpalia |
| 266-271 | Evaluation of the Feasibility and Use of a Prototype Remote Drug Delivery Capsule (RDDC) for Non-Invasive Regional Drug Absorption Studies in the GI Tract of Man and Beagle Dog | Alan F. Parr, Erik P. Sandefer, Paul Wissel, Mike McCartney and Craig McClain, et al. |
| 272-280 | The Effect of In Vivo Dissolution, Gastric Emptying Rate, and Intestinal Transit Time on the Peak Concentration and Area-Under-the-Curve of Drugs with Different Gastrointestinal Permeabilities | Lydia C. Kaus, William R. Gillespie, Ajaz S. Hussain and Gordon L. Amidon |
| 281-287 | Enantioselective Synthesis and Pharmacological Evaluation of a New Type of Verapamil Analog with Hypotensive and Calcium Antagonist Activities | Herbert L. Holland, Jian-Xin Gu, Francisco Orallo, Mercedes Camiña and Paula Fabeiro, et al. |
| 288-295 | Pharmacokinetics of Aminolevulinic Acid After Intravesical Administration to Dogs | James T. Dalton, Diansong Zhou, Arnab Mukherjee, David Young and Elizabeth A. Tolley, et al. |
| 296-301 | Enhanced Antinociception of the Model Opioid Peptide [D-Penicillamine2,5] Enkephalin by P-Glycoprotein Modulation | Cuiping Chen and Gary M. Pollack |
| 302-308 | Estimation of Intradermal Disposition Kinetics of Drugs: I. Analysis by Compartment Model with Contralateral Tissues | Kazuki Nakayama, Hisae Matsuura, Masahide Asai, Ken-ichi Ogawara and Kazutaka Higaki, et al. |
| 309-313 | Effects of Hyperlipidemia on the Pharmacokinetics of Nifedipine in the Rat | Lise A. Eliot, Robert T. Foster and Fakhreddin Jamali |
| 314-320 | Enhanced Accumulation of Sialyl Lewis X-Carboxymethylpullulan Conjugate in Acute Inflammatory Lesion | Kazutoshi Horie, Masahiro Sakagami, Kentaro Kuramochi, Kohji Hanasaki and Hiroshi Hamana, et al. |
| 321-326 | Peptidoleukotriene (PLT) Release and Absorption from the Airways of the Isolated Perfused Guinea Pig Lung Following Chemical and Antigenic Challenge | Rosemary A. Kovelesky, Peter R. Byron and Jürgen Venitz |
| 327-332 | Confocal Imaging of Peripheral Regions of Intact Rat Lungs Following Intratracheal Administration of 6-Carboxyfluorescein, FITC-insulin, and FITC-Dextran | Roderike Pohl, Roger S. Thrall, Rick A. Rogers and Paul A. Kramer |
| 333-337 | A New Method for Dissolution Studies of Lipid-Filled Capsules Employing Nifedipine as a Model Drug | Viness Pillay and Reza Fassihi |
| 339-341 | News from the National Institute of General Medical Sciences (NIGMS) | Rochelle M. Long |
| 342-349 | Pharmacogenetics as a Molecular Basis for Individualized Drug Therapy: The Thiopurine S-methyltransferase Paradigm | Eugene Y. Krynetski and William E. Evans |
| 350-358 | The Effect of Formulation Excipients on Protein Stability and Aerosol Performance of Spray-Dried Powders of a Recombinant Humanized Anti-IgE Monoclonal Antibody1 | James D. Andya, Yuh-Fun Maa, Henry R. Costantino, Phuong-Anh Nguyen and Nancy Dasovich, et al. |
| 359-367 | Degradation and Aggregation of Human Calcitonin In Vitro | Richard H. Lu, Pavla Kopečková and Jindřich Kopeček |
| 368-373 | Real Time Detection of Photoreactivity in Pharmaceutical Solids and Solutions with Isothermal Microcalorimetry | Vesa-Pekka Lehto, Jarno Salonen and Ensio Laine |
| 374-381 | Multiwavelength Spectrophotometric Determination of Acid Dissociation Constants: Part II. First Derivative vs. Target Factor Analysis | K. Y. Tarn and K. Takács-Novák |
| 382-390 | In Vitro Evaluation of Microparticles and Polymer Gels for Use as Nasal Platforms for Protein Delivery | Claudia Witschi and Randall J. Mrsny |
| 391-395 | Evidence for Overlapping Substrate Specificity Between Large Neutral Amino Acid (LNAA) and Dipeptide (hPEPTl) Transporters for PD 158473, an NMDA Antagonist | Narayanan Surendran, Kuang-Ming Y. Covitz, Hyo-kyung Han, Wolfgang Sadee and Doo-Man Oh, et al. |
| 396-401 | Inhibition of Multidrug Resistance-Associated Protein (MRP) Functional Activity with Pluronic Block Copolymers | Donald W. Miller, Elena V. Batrakova and Alexander V. Kabanov |
| 402-407 | Evidence for Different ABC-Transporters in Caco-2 Cells Modulating Drug Uptake | Heike Gutmann, Gert Fricker, Michael Török, Susanne Michael and Christoph Beglinger, et al. |
| 408-414 | Interrelationship Between Substrates and Inhibitors of Human CYP3A and P-Glycoprotein | Richard B. Kirn, Christoph Wandel, Brenda Leake, Mirjana Cvetkovic and Martin F. Fromm, et al. |
| 415-419 | Blood-Brain Barrier Transport of Reduced Folic Acid | Dafang Wu and William M. Pardridge |
| 420-426 | Radiolabeled Cholesteryl lopanoate/ Acetylated Low Density Lipoprotein as a Potential Probe for Visualization of Early Atherosclerotic Lesions in Rabbits | W. Xiao, L. Wang, T. Scott, R. E. Counsell and H. Liu |
| 427-433 | Self Promotion of Deep Tissue Penetration and Distribution of Methylsalicylate After Topical Application | Sheree E. Cross, Stella A. Megwa, Heather A. E. Benson and Michael S. Roberts |
| 434-440 | In Vitro and In Situ Permeability of a 'Second Generation' Hydroxypyridinone Oral Iron Chelator: Correlation with Physico-Chemical Properties and Oral Activity | Nicholas Lowther, Roy Fox, Bernard Faller, Hanspeter Nick and Yi Jin, et al. |
| 441-445 | Automated Absorption Assessment Using Caco-2 Cells Cultured on Both Sides of Polycarbonate Membranes | Per Garberg, Peder Eriksson, Nicolaas Schipper and Brita Sjöström |
| 446-454 | Evaluation of Viability of Excised Rat Intestinal Segments in the Ussing Chamber: Investigation of Morphology, Electrical Parameters, and Permeability Characteristics | Britta I. Polentarutti, Anders L. Peterson, Åsa K. Sjöberg, Eva Karin I. Anderberg and Lena M. Utter, et al. |
| 455-458 | Poor and Unusually Prolonged Oral Absorption of Amphotericin B in Rats | Gabriel Robbie, Ta-Chen Wu and Win L. Chiou |
| 459-462 | Changes in Skin A.C. Impedance Parameters In Vivo During the Percutaneous Absorption of Local Anesthetics | A. D. Woolfson, G. P. Moss, D. F. McCafferty, A. Lackermeier and E. T. McAdams |
| 463-465 | ZTTA, a Prolyl Endopeptidase Inhibitor, Potentiates the Arginine-Vasopressin-Induced Incorporation of [14C]Leucine in Rat Amygdaloid and Cortical Slices | Yoshiyuki Shishido, Takeshi Tanaka, Shuichi Tanabe, Masayoshi Furushiro and Shusuke Hashimoto, et al. |
| 466-469 | Cerebroside-β-Glucosidase Encapsulation in Liposomes for Gaucher's Disease Treatment Revisited | Veronica Korablyov, Avi Zimran and Yechezkel Barenholz |
| 470-473 | Development and Application of a Simple Assay to Quantify Cellular Adducts of Platinum Complexes with DNA | Charlotte Kloft, Christiane Eickhoff, Kai Schulze-Forster, H. Rainer Maurer and Walter Schunack, et al. |
| 475-477 | An Interview with a Distinguished Pharmaceutical Scientist: Robert S. Langer |
| 478-485 | Grapefruit Juice Activates P-Glycoprotein-Mediated Drug Transport | Andrea Soldner, Uwe Christians, Miki Susanto, Vincent J. Wacher and Jeffrey A. Silverman, et al. |
| 486-493 | Three-Dimensional Cultures of Prostatic Cells: Tissue Models for the Development of Novel Anti-Cancer Therapies | Kim C. O'Connor |
| 494-502 | Antisense Pharmacodynamics: Critical Issues in the Transport and Delivery of Antisense Oligonucleotides | R. L. Juliano, S. Alahari, H. Yoo, R. Kole and M. Cho |
| 503-508 | Characterization of Plasmid DNA Binding and Uptake by Peritoneal Macrophages from Class A Scavenger Receptor Knockout Mice | Yoshinobu Takakura, Toshihide Takagi, Miwa Hashiguchi, Makiya Nishikawa and Fumiyoshi Yamashita, et al. |
| 509-513 | Preparation and Characterization of Poly (D,L-Lactide-Co-Glycolide) Microspheres for Controlled Release of Poly(L-Lysine) Complexed Plasmid DNA | Yilmaz Capan, Byung H. Woo, Sisay Gebrekidan, Shamim Ahmed and Patrick P. DeLuca |
| 514-518 | Cell Loading with Laser-Generated Stress Waves: The Role of the Stress Gradient | Stephen E. Mulholland, Shun Lee, Daniel J. McAuliffe and Apostolos G. Doukas |
| 519-526 | Transport of Pregabalin in Rat Intestine and Caco-2 Monolayers | Nancy Jezyk, Cheng Li, Barbra H. Stewart, Xiaochun Wu and Howard N. Bockbrader, et al. |
| 527-533 | Biopharmaceutical Approaches for Developing and Assessing Oral Peptide Delivery Strategies and Systems: In Vitro Permeability and In Vivo Oral Absorption of Salmon Calcitonin | Patrick J. Sinko, Yong-Hee Lee, Vijaya Makhey, Glen D. Leesman and John P. Sutyak, et al. |
| 534-539 | Distribution Characteristics of Levofloxacin and Grepafloxacin in Rat Kidney | Tatsuya Ito, Ikuko Yano, Satohiro Masuda, Yukiya Hashimoto and Ken-ichi Inui |
| 540-544 | Different Activity of ATP Dependent Transport Across the Canalicular Membrane for Tributylmethyl-ammonium and Triethylmethyl-ammonium as a Potential Mechanism of the Preferential Biliary Excretion for Tributylmethylammonium in the Rat | Im-Sook Song, Suk-Jae Chung and Chang-Koo Shim |
| 545-548 | In Situ Determination of Delavirdine Mesylate Particle Size in Solid Oral Dosage Forms | Jackie G. White |
| 549-554 | Design and Evaluation of an Osmotic Pump Tablet (OPT) for Chlorpromazine Using (SBE)7m-β-CD | Kazuto Okimoto, Atsuo Ohike, Rinta Ibuki, Osamu Aoki and Norio Ohnishi, et al. |
| 555-561 | Large Porous Particles for Sustained Protection from Carbachol-Induced Bronchoconstriction in Guinea Pigs | Abdellaziz Ben-Jebria, Donghao Chen, Mary Lou Eskew, Rita Vanbever and Robert Langer, et al. |
| 562-568 | Cloud Point of Nonionic Surfactants: Modulation with Pharmaceutical Excipients | George C. Na, Barbara O. Yuan, H. Jack Stevens, Brian S. Weekley and Natarajan Rajagopalan |
| 569-574 | Physical Stability of Ethyl Diatrizoate Nanocrystalline Suspension in Steam Sterilization | George C. Na, Jack Stevens, Barbara O. Yuan and Natarajan Rajagopalan |
| 575-583 | Population Pharmacokinetics of Tirilazad: Effects of Weight, Gender, Concomitant Phenytoin, and Subarachnoid Hemorrhage | Joseph C. Fleishaker, Jill Fiedler-Kelly and Thaddeus H. Grasela |
| 584-586 | An Application of Ito's Lemma in Population Pharmacokinetics and Pharmacodynamics | Murali Ramanathan |
| 587-591 | Distribution and Binding Kinetics of Ciprofloxacin and Ofloxacin in the Hindlimb of the Rat | A. Sanchez-Navarro, A. C. Casquero-Dorado and M. Weiss |
| 593-596 | Interview with a Distinguished Pharmaceutical Scientist: Bernard Testa | Bernard Testa |
| 597-600 | Soluble Self-Assembled Block Copolymers for Drug Delivery | Glen S. Kwon and Teruo Okano |
| 601-608 | Monolayers of Human Alveolar Epithelial Cells in Primary Culture for Pulmonary Absorption and Transport Studies | Katharina J. Elbert, Ulrich F. Schäfer, Hans-Joachim Schäfers, Kwang-Jin Kim and Vincent H. L. Lee, et al. |
| 609-615 | Competitive Inhibition of Glycylsarcosine Transport by Enalapril in Rabbit Renal Brush Border Membrane Vesicles: Interaction of ACE Inhibitors with High-Affinity H+/Peptide Symporter | Chun-Jung Lin, Wiyada Akarawut and David E. Smith |
| 616-624 | The pH-Partition Profile of the Anti-Ischemic Drug Trimetazidine May Explain Its Reduction of Intracellular Acidosis | Frédéric Reymond, Guillaume Steyaert, Pierre-Alain Carrupt, Didier Morin and Jean-Paul Tillement, et al. |
| 625-632 | Interplay Between CYP3A-Mediated Metabolism and Polarized Efflux of Terfenadine and Its Metabolites in Intestinal Epithelial Caco-2 (TC7) Cell Monolayers | Shamsi D. Raeissi, Ismael J. Hidalgo, Juan Segura-Aguilar and Per Artursson |
| 633-636 | The Nitric Oxide Donor SIN-1 Is Free of Tolerance and Maintains Its Cyclic GMP Stimulatory Potency in Nitrate-Tolerant LLC-PK1 Cells | Burkhard Hinz and Henning Schröder |
| 637-642 | Brain Penetration and In Vivo Recovery of NMDA Receptor Antagonists Amantadine and Memantine: A Quantitative Microdialysis Study | Mayke B. Hesselink, Bert G. De Boer, Douwe D. Breimer and Wojciech Danysz |
| 643-650 | Immobilized Artificial Membrane (lAM)-HPLC for Partition Studies of Neutral and Ionized Acids and Bases in Comparison with the Liposomal Partition System | Cornelia Ottiger and Heidi Wunderli-Allenspach |
| 651-659 | NMR Studies of Retinoid-Protein Interactions: The Conformation of [13C]-β-Ionones Bound to β-Lactoglobulin B | Robert W. Curley, Appavu K. Sundaram, John W. Fowble, Frits Abildgaard and William M. Westler, et al. |
| 660-665 | Development of a Mathematical Model for the Water Distribution in Freeze-Dried Solids | Hak-Kim Chan, Kwok-Leung Au-Yeung and Igor Gonda |
| 666-671 | Magnetic Resonance Imaging (MRI) as a Method to Investigate Movement of Water During the Extrusion of Pastes | Gil Tomer, John Michael Newton and Paul Kinchesh |
| 672-675 | Determination of the Viscosity of an Amorphous Drug Using Thermomechanical Analysis (TMA) | Bruno C. Hancock, Yves Dupuis and Roch Thibert |
| 676-681 | Preparation of Biodegradable Microparticles Using Solution-Enhanced Dispersion by Supercritical Fluids (SEDS) | Raouf Ghaderi, Per Artursson and Johan Carlfors |
| 682-688 | A Novel System Based on a Poloxamer/ PLGA Blend as a Tetanus Toxoid Delivery Vehicle | María Tobío, Jessica Nolley, Yuyi Guo, James McIver and María José Alonso |
| 689-694 | Interaction of Naproxen with Alpha-Cyclodextrin and Its Noncyclic Analog Maltohexaose | Giampiero Bettinetti, Milena Sorrenti, Alessandra Negri, Massimo Setti and Paola Mura, et al. |
| 695-701 | Characterization of Recombinant Cytokine Fragments Using Isotachophoresis-Capillary Zone Electrophoresis, Reversed-Phase High Performance Liquid Chromatography, and Mass Spectrometry | J. Gysler, B. Helk, S. Dambacher, U. R. Tjaden and J. van der Greef |
| 702-708 | A Central Composite Design to Investigate the Thermal Stabilization of Lysozyme | Sébastien Branchu, Robert T. Forbes, Peter York and Håkan Nyqvist |
| 709-717 | The Effect of Collinearity on Parameter Estimates in Nonlinear Mixed Effect Models | Peter L. Bonate |
| 718-724 | Meal Composition Effects on the Oral Bioavailability of Indinavir in HIV-Infected Patients | Peggy L. Carver, David Fleisher, Simon Y. Zhou, Daniel Kaul and Powel Kazanjian, et al. |
| 725-735 | Production and Characterization of 22 Monoclonal Antibodies Directed Against S 20499, a New Potent 5-HT1A Chiral Agonist: Influence of the Hapten Structure on Specificity and Stereorecognition | Pierre Got, Eric Raimbaud, Cécile Bussey, Giulia Caron and Pierre-Alain Carrupt, et al. |
| 736-742 | Microdialysis Evaluation of the Ocular Pharmacokinetics of Propranolol in the Conscious Rabbit | Kay D. Rittenhouse, Robert L. Peiffer and Gary M. Pollack |
| 743-750 | Noninvasive Assessment of Tumor Hypoxia with 99mTc Labeled Metronidazole | David J. Yang, Seyfettin Ilgan, Tetsuya Higuchi, Fereshteh Zareneyrizi and Chang-Sok Oh, et al. |
| 751-757 | Body Distribution of Camptothecin Solid Lipid Nanoparticles After Oral Administration | Shicheng Yang, Jiabi Zhu, Yu Lu, Bingwen Liang and Changzheng Yang |
| 758-761 | Electrorepulsion Versus Electroosmosis: Effect of pH on the lontophoretic Flux of 5-Fluorouracil | Virginia Merino, Alicia López, Yogeshvar N. Kalia and Richard H. Guy |
| 762-765 | Preparation and Characterization of Carmustine Loaded Polyanhydride Wafers for Treating Brain Tumors | Abraham J. Domb, Zvi H. Israel, Omar Elmalak, Doron Teomim and Alfonso Bentolila |
| 766-771 | The Human Keratinocyte Cell Line HaCaT: An In Vitro Cell Culture Model for Keratinocyte Testosterone Metabolism | Ralf Altenburger and Thomas Kissel |
| 772-776 | Analyzing Rich Data Using Different Methods Provided by NONMEM: Pharmacokinetics of Telmisartan Following Intravenous Infusion to Healthy Volunteers | Gudrun Ch. Wallenstein, Joachim Stangier and Thomas M. Ludden |
| 777-781 | BOOK REVIEWS |
| 783-784 | News from the National Institute of General Medical Sciences (NIGMS) | Rochelle M. Long |
| 785-789 | An Interview with a Distinguished Pharmaceutical Scientist: William E. Evans | William E. Evans |
| 790-798 | Pharmacodynamics and Toxicodynamics of Drug Action: Signaling in Cell Survival and Cell Death | Ah-Ng Tony Kong, Sandhya Mandlekar, Rong Yu, Wei Lei and Adedigbo Fasanmande |
| 799-807 | Reversibility of Heat-Induced Denaturation of the Recombinant Human Megakaryocyte Growth and Development Factor | Linda O. Narhi, John S. Philo, Bin Sun, Byeong S. Chang and Tsutomu Arakawa |
| 808-812 | Investigation of Protein-Surfactant Interactions by Analytical Ultracentrifugation and Electron Paramagnetic Resonance: The Use of Recombinant Human Tissue Factor as an Example | LaToya S. Jones, David Cipolla, Jun Liu, Steven J. Shire and Theodore W. Randolph |
| 813-818 | Isolation, Characterization, and Stability of Positional Isomers of Mono-PEGylated Salmon Calcitonins | Kang Choon Lee, Seung Cheol Moon, Myung Ok Park, Jung Tae Lee and Dong Hee Na, et al. |
| 819-827 | Polymer Molecular Weight Alters Properties of pH-/Temperature-Sensitive Polymeric Beads | Chaaya Ramkissoon-Ganorkar, Anna Gutowska, Feng Liu, Miroslav Baudyš and Sung Wan Kim |
| 828-834 | Pharmaceutical Dry Powder Aerosols: Correlation of Powder Properties with Dose Delivery and Implications for Pharmacodynamic Effect | Neville M. Concessio, Michiel M. VanOort, Michael R. Knowles and Anthony J. Hickey |
| 835-840 | Differences in Crystallization Behavior Between Quenched and Ground Amorphous Ursodeoxycholic Acid | Etsuo Yonemochi, Yutaka Inoue, Graham Buckton, Anthony Moffat and Toshio Oguchi, et al. |
| 841-846 | Reduced UV-Induced Degradation of Doxorubicin Encapsulated in Polyethyleneglycol-Coated Liposomes | Suzan Bandak, Avner Ramu, Yechezkel Barenholz and Alberto Gabizon |
| 847-853 | pH and Osmotic Pressure Inside Biodegradable Microspheres During Erosion1 | Anette Brunner, Karsten Mäder and Achim Göpferich |
| 854-858 | Cyclodextrins as Diethylstilbestrol Carrier System: Characterization of Diethylstilbestrol-Cyclodextrins Complexes | Estrella Núñez-Delicado, Mar Sojo, Alvaro Sánchez-Ferrer and Francisco García-Carmona |
| 859-866 | Formulation and Lyoprotection of Poly(Lactic Acid-Co-Ethylene Oxide) Nanoparticles: Influence on Physical Stability and In Vitro Cell Uptake | Fanny De Jaeghere, Eric Allémann, Jean-Christophe Leroux, Wim Stevels and Jan Feijen, et al. |
| 867-875 | Enzymatic Degradation of Epichlorohydrin Crosslinked Starch Microspheres by α-Amylase | Ghania Hamdi and Gilles Ponchel |
| 876-881 | Polymers with Thiol Groups: A New Generation of Mucoadhesive Polymers? | Andreas Bernkop-Schnürch, Veronika Schwarz and Sonja Steininger |
| 882-888 | Drug Liposome Partitioning as a Tool for the Prediction of Human Passive Intestinal Absorption | K. Balon, B. U. Riebesehl and B. W. Müller |
| 889-895 | Synergistic Effect of Formulated Plasmid and Needle-Free Injection for Genetic Vaccines | Khursheed Anwer, Keith A. Earle, Mei Shi, Jijun Wang and Russell J. Mumper, et al. |
| 896-903 | Lipid Association Increases the Potency Against Primary Medulloblastoma Cells and Systemic Exposure of l-(2-Chloroethyl)-3-Cyclohexyl-1-Nitrosourea (CCNU) in Rats | Claudette Bethune, Aleksander Blum, J. Russell Geyer, John R. Silber and Rodney J. Y. Ho |
| 904-908 | Pravastatin, an HMG-CoA Reductase Inhibitor, Is Transported by Rat Organic Anion Transporting Polypeptide, oatp2 | Taro Tokui, Daisuke Nakai, Rie Nakagomi, Hiromu Yawo and Takaaki Abe, et al. |
| 909-915 | Effect of Concentration and Degree of Saturation of Topical Fluocinonide Formulations on In Vitro Membrane Transport and In Vivo Availability on Human Skin | Fabian P. Schwarb, Georgios Imanidis, Eric W. Smith, John M. Haigh and Christian Surber |
| 916-923 | Interaction Between Two Dicarboxylate Endogenous Substances, Bilirubin and an Uremic Toxin, 3-Carboxy-4-Methyl-5-Propyl-2-Furanpropanoic Acid, on Human Serum Albumin | Yasuhiro Tsutsumi, Toru Maruyama, Akira Takadate, Masafumi Goto and Hiroshi Matsunaga, et al. |
| 924-929 | Relationship Between Etomidate Plasma Concentration and EEG Effect in the Rat | Peter De Paepe, Gert Van Hoey, Frans M. Belpaire, Marie T. Rosseel and Paul A. Boon, et al. |
| 930-938 | Venous Irritation, Pharmacokinetics, and Tissue Distribution of Tirilazad in Rats Following Intravenous Administration of a Novel Supersaturated Submicron Lipid Emulsion | Youmin Wang, Gebre-Mariam Mesfin, Carlos A. Rodríguez, John G. Slatter and Margaret R. Schuette, et al. |
| 939-943 | Evaluation of Truncated Areas in the Assessment of Bioequivalence of Immediate Release Formulations of Drugs with Long Half-Lives and of Cmax with Different Dissolution Rates | Pradeep Sathe, Jurgen Venitz and Lawrence Lesko |
| 944-948 | Prediction of Pharmacokinetic Parameters and the Assessment of Their Variability in Bioequivalence Studies by Artificial Neural Networks | Jerneja Opara, Stanislav Primožič and Polona Cvelbar |
| 949-955 | Dipeptide Derivatives of Primaquine as Transmission-Blocking Antimalarials: Effect of Aliphatic Side-Chain Acylation on the Gametocytocidal Activity and on the Formation of Carboxyprimaquine in Rat Liver Homogenates | Maria João Portela, Rui Moreira, Emília Valente, Luis Constantino and Jim Iley, et al. |
| 956-960 | NO Donor and Biological Properties of Different Benzofuroxans1 | Claudio Medana, Antonella Di Stilo, Sonja Visentin, Roberta Fruttero and Alberto Gasco, et al. |
| 961-967 | Soft Drugs Based on Hydrocortisone: The Inactive Metabolite Approach and Its Application to Steroidal Antiinflammatory Agents | Roy J. Little, Nicholas Bodor and Thorsteinn Loftsson |
| 968-971 | Use of 1-Methyl-Pyrrolidone as a Solubilizing Agent for Determining the Uptake of Poorly Soluble Drugs | Antje S. Uch, Ulrich Hesse and Jennifer B. Dressman |
| 972 | ERRATUM |
| 972 | The Leiden/Amsterdam Center for Drug Research will be organizing the following courses: |
| 973-975 | An Interview with a Distinguished Pharmaceutical Scientist: George Zografi To whom correspondence should be addressed at University of Wisconsin—Madison, 425 N. Charter Street, Madison, Wisconsin 53706. | George Zografi |
| 976-985 | Phase Behavioral Effects on Particle Formation Processes Using Supercritical Fluids | Srinivas Palakodaty and Peter York |
| 986-996 | Comparison of the Anticancer Effect of Free and HPMA Copolymer-Bound Adriamycin in Human Ovarian Carcinoma Cells | Tamara Minko, Pavla Kopečková and Jindřich Kopeček |
| 997-1002 | A Novel Podophyllotoxin-Derived Compound GL331 Is More Potent than Its Congener VP-16 in Killing Refractory Cancer Cells | Tze-Sing Huang, Chun-Chung Lee, Yee Chao, Chih-Hung Shu and Li-Tzong Chen, et al. |
| 1003-1009 | Pharmacokinetic Features and Metabolism of Calphostin C, A Naturally Occurring Perylenequinone with Antileukemic Activity | Chun-Lin Chen, Hung-Liang Tai, De-Min Zhu and Fatih M. Uckun |
| 1010-1019 | Biorecognition of HPMA Copolymer-Adriamycin Conjugates by Lymphocytes Mediated by Synthetic Receptor Binding Epitopes | Vladimir Omelyanenko, Pavla Kopečková, Ramesh K. Prakash, Charles D. Ebert and Jindřich Kopeček |
| 1020-1025 | Intracellular Compartmentalization of DNA Fragments in Cultured Airway Epithelial Cells Mediated by Cationic Lipids | Adam R. Holmes, Austin F. Dohrman, Aaron R. Ellison, Kaarin K. Goncz and Dieter C. Gruenert |
| 1026-1034 | Structural Requirements for Alkylglycoside-Type Renal Targeting Vector | Kokichi Suzuki, Takashi Ando, Hiroshi Susaki, Kumiko Mimori and Satoru Nakabayashi, et al. |
| 1035-1040 | Inhibition of Intestinal Metabolism of the Antiviral Ester Prodrug bis(POC)-PMPA by Nature-Identical Fruit Extracts as a Strategy to Enhance Its Oral Absorption: An In Vitro Study | Jan Van Gelder, Pieter Annaert, Lieve Naesens, Erik De Clercq and Guy Van den Mooter, et al. |
| 1041-1046 | Development of Anti-Influenza Virus Drugs I: Improvement of Oral Absorption and In Vivo Anti-Influenza Activity of Stachyflin and Its Derivatives | Shigenori Yagi, Junko Ono, Jun Yoshimoto, Ken-ichi Sugita and Naohiko Hattori, et al. |
| 1047-1053 | Lipophilization of Somatostatin Analog RC-160 Improves Its Bioactivity and Stability | P. Dasgupta, A. T. Singh and R. Mukherjee |
| 1054-1058 | Thermodynamic In Vitro Studies as a Method to Investigate the Pharmacodynamic Behavior of Adenosine A1 Receptor Ligands | Alessandro Dalpiaz, Angelo Scatturin, Barbara Pavan, Katia Varani and Adriaan P. IJzerman, et al. |
| 1059-1066 | Anti-GAD Monoclonal Antibody Delays the Onset of Diabetes Mellitus in NOD Mice | Virginie Menard, Harvey Jacobs, Hee-Sook Jun, Ji-Woon Yoon and Sung Wan Kim |
| 1067-1073 | Cyclosporine Transfer from Low- and High-Density Lipoproteins Is Partially Influenced by Lipid Transfer Protein I Triglyceride Transfer Activity | Kishor M. Wasan, Ramaswamy Subramanian, Jenny Wen-Lin Chou, Manisha Ramaswamy and P. Haydn Pritchard |
| 1074-1080 | Carbomer Inhibits Tryptic Proteolysis of Luteinizing Hormone-Releasing Hormone and N-α-Benzoyl-L-Arginine Ethyl Ester by Binding the Enzyme | Greg F. Walker, Robin Ledger and Ian G. Tucker |
| 1081-1086 | Glucuronidation Kinetics of R,S-Ketoprofen in Adjuvant-Induced Arthritic Rats | Christine J. Meunier and Roger K. Verbeeck |
| 1087-1092 | Regional Differences in Quinine Absorption from the Undisturbed Human Colon Assessed Using a Timed Release Delivery System | John M. Hebden, Clive G. Wilson, Robin C. Spiller, Peter J. Gilchrist and Elaine Blackshaw, et al. |
| 1093-1097 | Improved Lipid Lowering Activity of Bezafibrate Following Continuous Gastrointestinal Administration: Pharmacodynamic Rationale for Sustained Release Preparation of the Drug | Amnon Hoffman, Yossef Lomnicky, Myron H. Luria, Dalia Gilhar and Michael Friedman |
| 1098-1103 | Influence of Particle Size, Air Flow, and Inhaler Device on the Dispersion of Mannitol Powders as Aerosols | Nora Y. K. Chew and Hak-Kim Chan |
| 1104-1108 | Solute Absorption from the Airways of the Isolated Rat Lung. V. Charge Effects on the Absorption of Copolymers of N(2-hydroxyethyl)-DL-Aspartamide with DL-Aspartic Acid or Dimethylaminopropyl-DL-Aspartamide | John Z. Sun, Peter R. Byron and Frantisek Rypacek |
| 1109-1113 | Confocal Raman-Spectroscopy: Analytical Approach to Solid Dispersions and Mapping of Drugs | Jörg Breitenbach, Wolfgang Schrof and Jörg Neumann |
| 1114-1118 | Biodegradable Nanoparticles Containing Doxorubicin-PLGA Conjugate for Sustained Release | Hyuk Sang Yoo, Jong Eun Oh, Keun Hyeung Lee and Tae Gwan Park |
| 1119-1124 | The Effects of Absorbed Water on the Properties of Amorphous Mixtures Containing Sucrose | Sheri L. Shamblin and George Zografi |
| 1125-1131 | Complex Formation Between The Anionic Polymer (PAA) and a Cationic Drug (Procaine HC1): Characterization by Microcalorimetric Studies | Thirumala Govender, Touraj Ehtezazi, Snjezana Stolnik, Lisbeth Illum and Stanley S. Davis |
| 1132-1135 | Effects of Arbekacin and Vancomycin on Release of Lactate Dehydrogenase and Fragmentation of DNA in LLC-PK1 Kidney Epithelial Cells | Tsutomu Nakamura, Toshiyuki Kokuryo, Masahiro Okuda, Yukiya Hashimoto and Ken-Ichi Inui |
| 1136-1139 | Development of an Unconventional In Vitro Drug Release Test Method for a Bile Acid Sequestrant, DMP 504, Tablet | Lei-Shu Wu, Timothy J. McCormick, Rong-Kun Chang, Josephine Pang and Tom McCummings, et al. |
| 1140-1143 | The Production of Uniformly Sized Polymer Microspheres | Brian Amsden |
| 1144-1146 | Truncated Area Under the Curve as a Measure of Relative Extent of Bioavailability: Evaluation Using Experimental Data and Monte Carlo Simulations | Andre J. Jackson and Larry A. Ouderkirk |
| 1147-1148 | News from the National Institute of General Medical Sciences (NIGMS) | Alisa Zapp Machalek |
| 1149-1152 | An Interview with a Distinguished Pharmaceutical Scientist: Sung Wan Kim To whom correspondence should be addressed at Biomedical Polymers Research Building, Room 205, University of Utah, Salt Lake City, Utah 84112. |
| 1153-1162 | Fluorescence Recovery After Photobleaching: A Versatile Tool for Mobility and Interaction Measurements in Pharmaceutical Research | Tom K. L. Meyvis, Stefaan C. De Smedt, Patrick Van Oostveldt and Joseph Demeester |
| 1163-1171 | Design of Potent Phosphorothioate Antisense Oligonucleotides Directed to Human Interleukin 10 Gene Product and Their Evaluation of Antisense Activity in U937 Cells | Hidetoshi Arima, Mamiko Takahashi, Yukihiko Aramaki, Takatoshi Sakamoto and Kazuhiro Yuda, et al. |
| 1172-1178 | Synthesis and In Vitro Evaluation of Aminoacyloxyalkyl Esters of 2-(6-methoxy-2-naphthyl)propionic Acid as Novel Naproxen Prodrugs for Dermal Drug Delivery | Jarkko Rautio, Tapio Nevalainen, Hannu Taipale, Jouko Vepsäläinen and Jukka Gynther, et al. |
| 1179-1185 | Synthesis of a Lipophilic Prodrug of 9-(2-Phosphonylmethoxyethyl)adenine (PMEA) and Its Incorporation into a Hepatocyte-Specific Lipidic Carrier | Remco L. A. de Vrueh, Erik T. Rump, Leo A. J. M. Sliedregt, Erik A. L. Biessen and Theo J. C. van Berkel, et al. |
| 1186-1192 | Solid-State Characteristics of Amorphous Sodium Indomethacin Relative to Its Free Acid | Ping Tong and George Zografi |
| 1193-1198 | Compaction Properties of Composite Particles Consisting of Lactose with Sodium Alginate Prepared by Spray-Drying | Hirofumi Takeuchi, Takehiko Yasuji, Tomoaki Hino, Hiromitsu Yamamoto and Yoshiaki Kawashima |
| 1199-1205 | Comparison of CYP2D6 Content and Metoprolol Oxidation Between Microsomes Isolated from Human Livers and Small Intestines | Soraya Madani, Mary F. Paine, Lydia Lewis, Kenneth E. Thummel and Danny D. Shen |
| 1206-1212 | Role of P-Glycoprotein on the CNS Disposition of Amprenavir (141W94), an HIV Protease Inhibitor | Joseph W. Polli, Jeanne L. Jarrett, Scott D. Studenberg, Joan E. Humphreys and Steven W. Dennis, et al. |
| 1213-1218 | P-Glycoprotein-Dependent Disposition Kinetics of Tacrolimus: Studies in mdr la Knockout Mice | Koichi Yokogawa, Megumi Takahashi, Ikumi Tamai, Hiroko Konishi and Masaaki Nomura, et al. |
| 1219-1225 | Pharmacokinetics of Methotrexate in the Extracellular Fluid of Brain C6-Glioma After Intravenous Infusion in Rats | Sylvain Dukic, Tony Heurtaux, Matthieu L. Kaltenbach, Guillaume Hoizey and Aude Lallemand, et al. |
| 1226-1232 | Evaluation of the Pharmacokinetic Features and Tissue Distribution of the Potent Nonnucleoside Inhibitor of HIV-1 Reverse Transcriptase, N-[2-(2-fluorophenethyl)]-N′-[2-(5-bromopyridyl)]-thiourea (HI-240) with an Analytical HPLC Method | Chun-Lin Chen and Fatih M. Uckun |
| 1233-1239 | Impact of Regional Intestinal pH Modulation on Absorption of Peptide Drugs: Oral Absorption Studies of Salmon Calcitonin in Beagle Dogs | Yong-Hee Lee, Barbara A. Perry, Stacy Labruno, HeeSang Lee and William Stern, et al. |
| 1240-1244 | Gastropods as an Evaluation Tool for Screening the Irritating Potency of Absorption Enhancers and Drugs | Els Adriaens and JeanPaul Remon |
| 1245-1253 | Membrane-Interaction QSAR Analysis: Application to the Estimation of Eye Irritation by Organic Compounds | Amit S. Kulkarni and A.J. Hopfinger |
| 1254-1259 | Stool Water Content and Colonic Drug Absorption: Contrasting Effects of Lactulose and Codeine | John M. Hebden, Peter J. Gilchrist, Alan C. Perkins, Clive G. Wilson and Robin C. Spiller |
| 1260-1265 | Likelihood-Based Diagnostics for Influential Individuals in Non-Linear Mixed Effects Model Selection | Sima Sadray, E.Niclas Jonsson and Mats O. Karlsson |
| 1266-1272 | Transcellular and Lipophilic Complex-Enhanced Intestinal Absorption of Human Growth Hormone | Sy-Juen Wu and Joseph R. Robinson |
| 1273-1279 | A Novel Non-Viral Vector for DNA Delivery Based on Low Molecular Weight, Branched Polyethylenimine: Effect of Molecular Weight on Transfection Efficiency and Cytotoxicity | Dagmar Fischer, Thorsten Bieber, Youxin Li, Hans-Peter Elsässer and Thomas Kissel |
| 1280-1287 | Organic Cation Transport in Rabbit Alveolar Epithelial Cell Monolayers | Jie Shen, Katharina J. Elbert, Fumiyoshi Yamashita, Claus-Michael Lehr and Kwang-Jin Kim, et al. |
| 1288-1293 | Chemical Uptake Into Human Stratum Corneum In Vivo from Volatile and Non-Volatile Solvents | Audra L. Stinchcomb, Fabrice Pirot, Gilles D. Touraille, Annette L. Bunge and Richard H. Guy |
| 1294-1299 | Why Does PEG 400 Co-Encapsulation Improve NGF Stability and Release from PLGA Biodegradable Microspheres? | Jean-Manuel Péan, Franck Boury, Marie-Claire Venier-Julienne, Philippe Menei and Jacques-Emile Proust, et al. |
| 1300-1308 | Controlled DNA Delivery Systems | Dan Luo, Kim Woodrow-Mumford, Nadya Belcheva and W.Mark Saltzman |
| 1309-1315 | Pharmacokinetics and Tissue Disposition in Monkeys of an Antisense Oligonucleotide Inhibitor of Ha-Ras Encapsulated in Stealth Liposomes | Rosie Z. Yu, Richard S. Geary, Janet M. Leeds, Tanya Watanabe and Jonathon R. Fitchett, et al. |
| 1316-1319 | Determination of Air Content in Protein Microspheres | Svein Kvåle, Knut R. Dyrstad, Per C. Sontum and Odd A. Asbjørnsen |
| 1320-1324 | BOOK REVIEWS |
| 1324 | ERRATUM |
| 1325-1330 | Assessment of Value and Applications of In Vitro Testing of Topical Dermatological Drug Products | Gordon L. Flynn, Vinod P. Shah, Srinivas N. Tenjarla, Michael Corbo and David DeMagistris, et al. |
| 1331-1343 | Intestinal Peptide Transport Systems and Oral Drug Availability | Cheng Y. Yang, Anne H. Dantzig and Charles Pidgeon |
| 1344-1351 | Effect of Technical and Functional Quality on Patient Perceptions of Pharmaceutical Service Quality | David Holdford and Richard Schulz |
| 1352-1359 | Transport and Metabolic Characterization of Caco-2 Cells Expressing CYP3A4 and CYP3A4 Plus Oxidoreductase | Ming Hu, Yiqi Li, Christine M. Davitt, Shiew-Mei Huang and Kenneth Thummel, et al. |
| 1360-1365 | Cereport™ (RMP-7) Increases the Permeability of Human Brain Microvascular Endothelial Cell Monolayers1 | Jasmina B. Mackic, Monique Stins, Suzana Jovanovic, KwangSik Kim and Raymond T. Bartus, et al. |
| 1366-1372 | Pluronic P85 Increases Permeability of a Broad Spectrum of Drugs in Polarized BBMEC and Caco-2 Cell Monolayers | Elena V. Batrakova, Shu Li, Donald W. Miller and Alexander V. Kabanov |
| 1373-1379 | Fundamental Relationships Between the Composition of Pluronic Block Copolymers and Their Hypersensitization Effect in MDR Cancer Cells | Elena Batrakova, Shengmin Lee, Shu Li, Annie Venne and Valery Alakhov, et al. |
| 1380-1385 | Effects of Pharmaceutical Compounds on Ciliary Beating in Human Nasal Epithelial Cells: A Comparative Study of Cell Culture Models | Remigius Uchenna Agu, Mark Jorissen, Tom Willems, Guy Van den Mooter and Renaat Kinget, et al. |
| 1386-1391 | Skin Penetration and Metabolism of Topical Glucocorticoids in Reconstructed Epidermis and in Excised Human Skin | Anja Gysler, Burkhard Kleuser, Wolfgang Sippl, Katharina Lange and HansChristian Korting, et al. |
| 1392-1398 | A Physiological Pharmacokinetic Model for Solute Disposition in Tissues Below a Topical Application Site | Michael S. Roberts and Sheree E. Cross |
| 1399-1406 | Synthesis and Preclinical Pharmacology of 2-(2-Aminopyrimidinio) Ethylidene-1,1-Bisphosphonic Acid Betaine (ISA-13-1)-A Novel Bisphosphonate | Hagit Cohen, Ivan S. Alferiev, Jukka Mönkkönen, Markus J. Seibel and Taly Pinto, et al. |
| 1407-1411 | A New Specific Enzyme Immunoassay Allowing an Efficient Pharmacokinetic Evaluation of γ-Cyclodextrin After Intravenous Administration to Rats | Christophe Créminon, Florence Djedaïni-Pilard, Raymond Vienet, Christophe Péan and Jean-Marc Grognet, et al. |
| 1412-1416 | Pharmacokinetic-Pharmacodynamic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide, in Human Volunteers | Jogarao V. S. Gobburu, Henrik Agersø, William J. Jusko and Lars Ynddal |
| 1417-1423 | Long Term Stability of Poly((2-dimethylamino)ethyl Methacrylate)-Based Gene Delivery Systems | Jong-Yuh Cherng, Herre Talsma, Daan J. A. Crommelin and Wim E. Hennink |
| 1424-1429 | Evaluation of an Enzyme-Containing Capsular Shaped Pulsatile Drug Delivery System | Ina Krögel and Roland Bodmeier |
| 1430-1435 | A Heterogeneously Structured Composite Based on Poly(lactic-co-glycolic acid) Microspheres and Poly(vinyl alcohol) Hydrogel Nanoparticles for Long-Term Protein Drug Delivery | Nuo Wang, XueShen Wu and JiaKui Li |
| 1436-1440 | Substituted Amylose as a Matrix for Sustained Drug Release | Chafic Chebli, Iskandar Moussa, Stéphane Buczkowski and Louis Cartilier |
| 1441-1448 | Structural and Dynamic Properties of Crystalline and Amorphous Phases in Raffinose-Water Mixtures | Kazuhito Kajiwara, Felix Franks, Patrick Echlin and A.Lindsay Greer |
| 1449-1455 | Influence of the Organization of Binary Mixes on Their Compactibility | J. Barra, F. Falson-Rieg and E. Doelker |
| 1456-1463 | Model-Based Interpretation of Creep Profiles for the Assessment of Polymer-Mucin Interaction | Silvia Rossi, M.Cristina Bonferoni, Carla Caramella, Liliana Ironi and Stefania Tentoni |
| 1464-1469 | Determination of the Glass Transition Temperatures of Some New Methyl Methacrylate Copolymers Using Modulated Temperature Differential Scanning Calorimetry (MTDSC) | M.C. Ferrero, M.V. Velasco, J.L. Ford, A.R. Rajabi-Siahboomi and A. Muñoz, et al. |
| 1470-1476 | Does the Dose-Solubility Ratio Affect the Mean Dissolution Time of Drugs? | Petr Lánsky and Michael Weiss |
| 1477-1482 | Solid State Assay of Ranitidine HCl as a Bulk Drug and as Active Ingredient In Tablets Using DRIFT Spectroscopy with Artificial Neural Networks | Snezana Agatonovic-Kustrin, Ian G. Tucker and David Schmierer |
| 1483-1486 | Calcium Responsive Bioerodible Drug Delivery System | Riki Goldbart and Joseph Kost |
| 1487-1490 | Alteration of Cytokeratin Expression Following Transdermal Lidocaine Hydrochloride Iontophoresis | D.G. Allen and N.A. Monteiro-Riviere |
| 1491-1493 | Enhancement of Phospholipase A2 Catalyzed Degradation of Polymer Grafted PEG-Liposomes: Effects of Lipopolymer-Concentration and Chain-Length | K. Jørgensen, C. Vermehren and O. G. Mouritsen |
| 1495-1497 | News from the National Institute of General Medical Sciences (NIGMS) | W. Sue Shafer |
| 1498-1505 | Therapeutic Targets for Hypoxia-Elicited Pathways | Cormac T. Taylor and Sean P. Colgan |
| 1506-1513 | Molecular Modeling Study of Diltiazem Mimics at L-Type Calcium Channels | Klaus-Jürgen Schleifer and Edith Tot |
| 1514-1519 | Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs | Jan Kelder, Peter D. J. Grootenhuis, Denis M. Bayada, Leon P. C. Delbressine and Jan-Peter Ploemen |
| 1520-1526 | Prediction of the Intestinal Absorption of Endothelin Receptor Antagonists Using Three Theoretical Methods of Increasing Complexity | Patric Stenberg, Kristina Luthman, Harma Ellens, Chao Pin Lee and Philip L. Smith, et al. |
| 1527-1533 | Prodrug Approach for αΙΙbβ3-Peptidomimetic Antagonists to Enhance Their Transport in Monolayers of a Human Intestinal Cell Line (Caco-2): Comparison of In Vitro and In Vivo Data | Walter Kamm, Peter Raddatz, Joachim Gante and Thomas Kissel |
| 1534-1541 | Association and Dissociation Characteristics of Polymer/DNA Complexes Used for Gene Delivery | Carmen Arigita, Nicolaas Jan Zuidam, Daan J. A. Crommelin and Wim E. Hennink |
| 1542-1549 | Distribution of a 20-Mer Phosphorothioate Oligonucleotide, CGP69846A (ISIS 5132), into Airway Leukocytes and Epithelial Cells Following Intratracheal Delivery to Brown-Norway Rats | Henry Danahay, June Giddings, Robin A. Christian, Heinz E. Moser and Judy A. Phillips |
| 1550-1556 | Inhibition of P-Glycoprotein by D-α-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS) | Jay M. Dintaman and Jeffrey A. Silverman |
| 1557-1563 | Oral Mucosal Permeability and Stability of Transforming Growth Factor Beta-3 In Vitro | Christopher A. Squier, Mary J. Kremer, Arnold Bruskin, Ann Rose and John D. Haley |
| 1564-1569 | Significant Transport of Doxorubicin into the Brain with Polysorbate 80-Coated Nanoparticles | Alexander E. Gulyaev, Svetlana E. Gelperina, Igor N. Skidan, Arkady S. Antropov and Gregory Ya. Kivman, et al. |
| 1570-1575 | Epithelial Transport of Anthelmintic Ivermectin in a Novel Model of Isolated Proximal Kidney Tubules | Gert Fricker, Heike Gutmann, Agathe Droulle, Jürgen Drewe and David S. Miller |
| 1576-1581 | Enhancement of Nasal Absorption of Insulin Using Chitosan Nanoparticles | Rocío Fernández-Urrusuno, Pilar Calvo, Carmen Remuñán-López, Jose Luis Vila-Jato and María José Alonso |
| 1582-1588 | Stereoselective Pharmacokinetics and Pharmacodynamics of Propylisopropyl Acetamide, a CNS-Active Chiral Amide Analog of Valproic Acid | Ofer Spiegelstein, Boris Yagen, René H. Levy, Richard H. Finnell and Gregory D. Bennett, et al. |
| 1589-1595 | Effects of Disopyramide and Verapamil on Renal Disposition and Nephrotoxicity of Cisplatin in Rats | Kazuhiko Hanada, Kentaro Odaka, Akemi Kudo and Hiroyasu Ogata |
| 1596-1601 | Characterization of Ocular Pharmacokinetics of Beta-Blockers Using a Diffusion Model After Instillation | Kenzo Yamamura, Hitoshi Sasaki, Mikiro Nakashima, Masataka Ichikawa and Takahiro Mukai, et al. |
| 1602-1607 | Percutaneous Absorption of Sunscreens Through Micro-Yucatan Pig Skin In Vitro | Vinod K. Gupta, Joel L. Zatz and Mark Rerek |
| 1608-1615 | A Pharmacokinetic Model for Tenidap in Normal Volunteers and Rheumatoid Arthritis Patients | Lynne Evans, Leon Aarons and Peter Coates |
| 1616-1620 | Suppression of Agglomeration in Fluidized Bed Coating. III. Hofmeister Series in Suppression of Particle Agglomeration | Tatsu Nakano, Hiroshi Yuasa and Yoshio Kanaya |
| 1621-1625 | Molecular Mobility of Protein in Lyophilized Formulations Linked to the Molecular Mobility of Polymer Excipients, as Determined by High Resolution 13C Solid-State NMR | Sumie Yoshioka, Yukio Aso, Shigeo Kojima, Satoshi Sakurai and Toshimichi Fujiwara, et al. |
| 1626-1632 | Inhibition of Succinimide Formation in Aqueous Zn-rHirudin Suspensions1 | Ursula Gietz, Tudor Arvinte, Ruth Alder and Hans P. Merkle |
| 1633-1638 | Ion-Pair Partition of Quaternary Ammonium Drugs: The Influence of Counter Ions of Different Lipophilicity, Size, and Flexibility | Krisztina Takács-Novák and György Szász |
| 1639-1642 | A New Microphotolysis Based Approach for Mapping the Mobility of Drugs in Microscopic Drug Delivery Devices | Stefaan C. De Smedt, Tom K. L. Meyvis, Patrick Van Oostveldt and Joseph Demeester |
| 1643-1647 | Enhancement of Small Particle Size Dry Powder Aerosol Formulations using an Ultra Low Density Additive | Paul Lucas, Kerry Anderson, Ursula J. Potter and John N. Staniforth |
| 1648-1652 | Comparison of Nasal Deposition and Clearance of Aerosol Generated by a Nebulizer and an Aqueous Spray Pump | Julie D. Suman, Beth L. Laube and Richard Dalby |
| 1653-1657 | Effect of Baicalin on Tracheal Permeability in Ovalbumin (OA)-Sensitized Guinea Pigs | Jiahorng Liaw, Yi-Ying Gau and Yen-Chin Chao |
| 1658-1661 | 1H NMR Quantification of poly(Ethylene Glycol)-Phosphatidylethanolamine in Phospholipid Mixtures | E. A. A. M. Vernooij, C. A. Gentry, J. N. Herron, D. J. A. Crommelin and J. J. Kettenes-van den Bosch |
| 1674-1679 | Preparation, Purification, and Characterization of a Reversibly Lipidized Desmopressin with Potentiated Anti-Diuretic Activity | Jeff Wang, Daisy Shen and Wei-Chiang Shen |
| 1680-1686 | NBl-C16-Insulin: Site-Specific Synthesis, Purification, and Biological Activity | Hong Mei, X. Christopher Yu and Kenneth K. Chan |
| 1687-1693 | Aryl Ester Prodrugs of Cyclic HPMPC. I: Physicochemical Characterization and In Vitro Biological Stability | Reza Oliyai, Jeng-Pyng Shaw, Cathy M. Sueoka-Lennen, Kenneth C. Cundy and Murty N. Arimilli, et al. |
| 1694-1701 | Safety and Toxicokinetics of Intravenous Liposomal Amphotericin B (AmBisome ®) in Beagle Dogs | Ihor Bekersky, Garry W. Boswell, Richard Hiles, Robert M. Fielding and Donald Buell, et al. |
| 1702-1709 | Mechanism-Based Modeling of Adaptive Changes in the Pharmacodynamics of Midazolam in the Kindling Model of Epilepsy | Adriaan Cleton, Piet Hein Van der Graaf, Wim Ghijsen, Rob Voskuyl and Meindert Danhof |
| 1710-1716 | Ability of Doxorubicin-Loaded Nanoparticles to Overcome Multidrug Resistance of Tumor Cells After Their Capture by Macrophages | Claire Emilienne Soma, Catherine Dubernet, Gillian Barratt, Fariba Nemati and Martine Appel, et al. |
| 1717-1721 | Topical Drug Delivery in Humans with a Single Photomechanical Wave | Shun Lee, Nikiforos Kollias, Daniel J. McAuliffe, Thomas J. Flotte and Apostolos G. Doukas |
| 1722-1728 | Physical Properties of Solid Molecular Dispersions of Indomethacin with Poly(vinylpyrrolidone) and Poly(vinylpyrrolidone-co-vinyl-acetate) in Relation to Indomethacin Crystallization | Takahiro Matsumoto and George Zografi |
| 1729-1734 | Solid-State 13C Nuclear Magnetic Resonance Spectroscopic Study on Amorphous Solid Complexes of Tolbutamide with 2-Hydroxypropyl-α-and -β-Cyclodextrins | Kenya Kimura, Fumitoshi Hirayama, Hidetoshi Arima and Kaneto Uekama |
| 1735-1742 | Formulation and Physical Characterization of Large Porous Particles for Inhalation | Rita Vanbever, Jeffrey D. Mintzes, Jue Wang, Jacquelyn Nice and Donghao Chen, et al. |
| 1743-1747 | High Resolution Size Determination of 20 nm Colloidal Gold Particles by SedFFF | Stephan Anger, Karin Caldwell, Horst Niehus and Rainer H. Müller |
| 1748-1756 | HPMC-Matrices for Controlled Drug Delivery: A New Model Combining Diffusion, Swelling, and Dissolution Mechanisms and Predicting the Release Kinetics | J. Siepmann, H. Kranz, R. Bodmeier and N. A. Peppas |
| 1757-1763 | Proton Speciation and Microspeciation of Vinpocetine and Related Compounds in Aqueous and Biomimetic Media | Károly Mazák, András Nemes and Béla Noszál |
| 1764-1769 | A Heterogeneous Tube Model of Intestinal Drug Absorption Based on Probabilistic Concepts | Alkiviadis Kalampokis, Panos Argyrakis and Panos Macheras |
| 1770-1774 | Transport of NG-Nitro-L-Arginine Across Intestinal Brush Border Membranes by Na+-Dependent and Na+ Independent Amino Acid Transporters | Takahiro Hatanaka, Yoshiaki Nabuchi and Hidetoshi Ushio |
| 1775-1780 | In Vitro-In Vivo Evaluation of a Controlled Release Buccal Bioadhesive Device for Oral Drug Delivery | Deepak Tiwari, David Goldman, Chris Town, Robert Sause and Parshotam L. Madan |
| 1781-1785 | Regulation of Paracellular Absorption of Cimetidine and 5-Aminosalicylate in Rat Intestine | Simon Yuji Zhou, Nusara Piyapolrungroj, Li-heng Pao, Cheng Li and Guangyu Liu, et al. |
| 1786-1789 | Improvement of the Intestinal Absorption of a Peptidomimetic, Boronic Acid Thrombin Inhibitor Possibly Utilizing the Oligopeptide Transporter | Hiroshi Saitoh and Bruce J. Aungst |
| 1791-1792 | News from the National Institute of General Medical Sciences (NIGMS) | Peter C. Preusch |
| 1793-1795 | An Interview of a Distinguished Pharmaceutical Scientist: Tsuneji Nagai |
| 1796-1798 | Some Important Considerations in the Use of Cyclodextrins | James Blanchard and Stefan Proniuk |
| 1799-1804 | PAMAM Dendrimers as Delivery Agents for Antisense Oligonucleotides | Hoon Yoo, Peter Sazani and R. L. Juliano |
| 1805-1811 | Cationic Lipid-Mediated Transfection of Differentiated Caco-2 Cells: A Filter Culture Model of Gene Delivery to a Polarized Epithelium | Aimalohi N. Uduehi, Stephen H. Moss, Joanne Nuttall and Colin W. Pouton |
| 1812-1817 | Vitamin E-TPGS Increases Absorption Flux of an HIV Protease Inhibitor by Enhancing Its Solubility and Permeability1 | Lawrence Yu, Avis Bridgers, Joseph Polli, Ann Vickers and Stacey Long, et al. |
| 1818-1824 | Ionized Prodrugs of Dehydroepiandrosterone for Transdermal lontophoretic Delivery | Sonia Laneri, Antonia Sacchi, Enrico Abignente di Frassello, Elena Luraschi and Paolo Colombo, et al. |
| 1825-1829 | Sustained Release of Human Growth Hormone from PLGA Solution Depots | Kevin J. Brodbeck, Shamim Pushpala and Anthony J. McHugh |
| 1830-1835 | Chitosan-Gadopentetic Acid Complex Nanoparticles for Gadolinium Neutron-Capture Therapy of Cancer: Preparation by Novel Emulsion-Droplet Coalescence Technique and Characterization | Hiroyuki Tokumitsu, Hideki Ichikawa and Yoshinobu Fukumori |
| 1836-1842 | Indirect Evidence that Drug Brain Targeting Using Polysorbate 80-Coated Polybutylcyanoacrylate Nanoparticles Is Related to Toxicity | Jean-Christophe Olivier, Laurence Fenart, Romain Chauvet, Claudine Pariat and Roméo Cecchelli, et al. |
| 1843-1849 | Reduction of Maturation Phenomenon in Cerebral Ischemia with CDP-Choline-Loaded Liposomes1 | Massimo Fresta and Giovanni Puglisi |
| 1850-1856 | Tablet Dissolution Affected by a Moisture Mediated Solid-State Interaction Between Drug and Disintegrant | Brian R. Rohrs, Thomas J. Thamann, Ping Gao, Dennis J. Stelzer and Micheal S. Bergren, et al. |
| 1857-1863 | Analysis of a Diffusion Dryer for the Respiratory Delivery of Poorly Water Soluble Drugs | Stephen Pham and Timothy S. Wiedmann |
| 1864-1870 | Application of Supercritical Carbon Dioxide for the Preparation of a Piroxicam-β-Cyclodextrin Inclusion Compound | Thierry Van Hees, Geraldine Piel, Brigitte Evrard, Xavier Otte and Leopold Thunus, et al. |
| 1871-1875 | Albendazole Generics—A Comparative In Vitro Study | E. Galia, J. Horton and J. B. Dressman |
| 1876-1882 | Forecasting the In Vivo Performance of Four Low Solubility Drugs from Their In Vitro Dissolution Data | Eleftheria Nicolaides, Eric Galia, Constantin Efthymiopoulos, Jennifer B. Dressman and Christos Reppas |
| 1883-1887 | An Integrated Model for Determining Causes of Poor Oral Drug Absorption | Lawrence X. Yu |
| 1888-1892 | Effects of Interactions Between Drugs on the Renal Excretion of Trientine in Rats—Acetazolamide and Furosemide Increase Trientine Excretion | Michiya Kobayashi, Hiroko Fujisaki, Mitsuru Sugawara, Ken Iseki and Katsumi Miyazaki |
| 1893 | Absorption Potential and Its Variants | Harold Boxenbaum |
| 1894-1897 | Antagonistic Interaction Between the Convulsant Activities of Pefloxacin and Its Main Metabolite Norfloxacin in Rats | Annie Delon, Laurence M. Levasseur, Mylène Giraudon, Serge Bouquet and William Couet |
| 1898-1900 | Reviewers for Pharmaceutical Research November 1998 Through October 1999 |
| 1901-1905 | Author Index to Volume 16 (1999) |
| 1906-1910 | Subject Index to Volume 16 (1999) |
| 1-6 | An Interview with a Distinguished Pharmaceutical Scientist: Douwe D. Breimer–Elected Foreign Associate Member of the Institute of Medicine of the National Academy of Sciences of the U.S.A. (1999) |
| 7-14 | Systematic Investigations of the Influence of Molecular Structure on the Transport of Peptides Across Cultured Alveolar Cell Monolayers | A. N. O. Dodoo, S. Bansal, D. J. Barlow, F. C. Bennet and R. C. Hider, et al. |
| 15-20 | N-terminal Halves of Rat H+/Peptide Transporters Are Responsible for Their Substrate Recognition | Tomohiro Terada, Hideyuki Saito, Kyoko Sawada, Yukiya Hashimoto and Ken-ichi Inui |
| 21-26 | Induction of UDP-Glucuronosyl-Transferase by the Flavonoids Chrysin and Quercetin in Caco-2 Cells | Alema Galijatovic, U. Kristina Walle and Thomas Walle |
| 27-31 | N-Trimethylated Chitosan Chloride (TMC) Improves the Intestinal Permeation of the Peptide Drug Buserelin In Vitro (Caco-2 Cells) and In Vivo (Rats) | M. Thanou, B. I. Florea, M. W. E. Langemeÿer, J. C. Verhoef and H. E. Junginger |
| 32-37 | Transdermal Delivery of Macromolecules Using Skin Electroporation | Catherine Lombry, Nathalie Dujardin and Véronique Préat |
| 38-41 | Surface Active Agents as Enhancers of Alveolar Absorption | Per Wollmer, Kjell Bäckström, Hong Zhao, Per-Gunnar Nilsson and Björn Jonson |
| 42-48 | Liposomes Containing Interferon-Gamma as Adjuvant in Tumor Cell Vaccines | M. L. van Slooten, G. Storm, A. Zoephel, Z. Küpcü and O. Boerman, et al. |
| 49-54 | Detection of the Membrane Protein Recognized by the Kidney-Specific Alkylglucoside Vector | Yuka Watanabe, Hiroshi Suzuki, Kokichi Suzuki, Takashi Ando and Satoru Nakabayashi, et al. |
| 55-62 | Functional Clarification of MCT1-Mediated Transport of Monocarboxylic Acids at the Blood-Brain Barrier Using In Vitro Cultured Cells and In Vivo BUI Studies | Yasuto Kido, Ikumi Tamai, Mototsugu Okamoto, Fumio Suzuki and Akira Tsuji |
| 63-69 | Blood-Brain Barrier Transport of 125I-Labeled Basic Fibroblast Growth Factor | Yoshiharu Deguchi, Takafumi Naito, Takuro Yuge, Akihiko Furukawa and Shizuo Yamada, et al. |
| 70-76 | Evaluation of Blood-Brain Barrier Passage of a Muscarine M1 Agonist and a Series of Analogous Tetrahydropyridines Measured by In Vivo Microdialysis | Helle Hagen Sveigaard and Lars Dalgaard |
| 77-84 | Population Pharmacokinetics of Fast Release Oral Diclofenac in Healthy Volunteers: Relation to Pharmacodynamics in an Experimental Pain Model | Jörn Lötsch, Birgit Kettenmann, Bertold Renner, David Drover and Kay Brune, et al. |
| 85-89 | pH-Metric Solubility. 2: Correlation Between the Acid-Base Titration and the Saturation Shake-Flask Solubility-pH Methods | Alex Avdeef, Cynthia M. Berger and Charles Brownell |
| 90-93 | Quantitative Relationship Between Solubility, Initial Dissolution Rate and Heat of Solution of Chiral Drugs | Etsuo Yonemochi, Yasuo Yoshihashi and Katsuhide Terada |
| 94-99 | Spray-Dried Lactose Composite Particles Containing an Ion Complex of Alginate-Chitosan for Designing a Dry-Coated Tablet Having a Time-Controlled Releasing Function | Hirofumi Takeuchi, Takehiko Yasuji, Hiromitsu Yamamoto and Yoshiaki Kawashima |
| 100-106 | Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres | Karen Fu, Daniel W. Pack, Alexander M. Klibanov and Robert Langer |
| 107 | News from the National Institute of General Medical Sciences (NIGMS) | Michael E. Rogers |
| 108-112 | On the Heterogeneity of Drug Dissolution and Release | Panos Macheras and Aristides Dokoumetzidis |
| 113-126 | Cationic Polymer Based Gene Delivery Systems | Stefaan C. De Smedt, Joseph Demeester and Wim E. Hennink |
| 127-134 | An Isolated In-Situ Rat Head Perfusion Model for Pharmacokinetic Studies | Kelley A. Foster, George D. Mellick, Michael Weiss and Michael S. Roberts |
| 135-140 | Evaluation of Using Dog as an Animal Model to Study the Fraction of Oral Dose Absorbed of 43 Drugs in Humans | Win L. Chiou, Hyun Y. Jeong, Sang M. Chung and Ta C. Wu |
| 141-147 | Microdialysis Technique as a Method to Study the Percutaneous Penetration of Methyl Nicotinate Through Excised Human Skin, Reconstructed Epidermis, and Human Skin In Vivo | Esther Boelsma, Chris Anderson, Anneli M. J. Karlsson and Maria Ponec |
| 148-153 | Distribution of Gacyclidine Enantiomers in Spinal Cord Extracellular Fluid | Guillaume Hoizey, Matthieu L. Kaltenbach, Sylvain Dukic, Denis Lamiable and Aude Lallemand, et al. |
| 154-159 | Comparison of Zafirlukast (Accolate®) Absorption After Oral and Colonic Administration in Humans | Jeff D. Fischer, Min H. Song, A. Benjamin Suttle, William D. Heizer and Charles B. Burns, et al. |
| 160-167 | Application of a Biomagnetic Measurement System (BMS) to the Evaluation of Gastrointestinal Transit of Intestinal Pressure-Controlled Colon Delivery Capsules (PCDCs) in Human Subjects | Zhaopeng Hu, Shunsuke Mawatari, Nobuhito Shibata, Kanji Takada and Hiroshi Yoshikawa, et al. |
| 168-174 | Hollow Porous Particles in Metered Dose Inhalers | Luis A. Dellamary, Thomas E. Tarara, Dan J. Smith, Christopher H. Woelk and Anastasios Adractas, et al. |
| 175-182 | Formulation Development and Antitumor Activity of a Filter-Sterilizable Emulsion of Paclitaxel | Panayiotis P. Constantinides, Karel J. Lambert, Alex K. Tustian, Brian Schneider and Salima Lalji, et al. |
| 183-189 | Dissolution of Hydrocortisone in Human and Simulated Intestinal Fluids | Betty Lomstein Pedersen, Helle Brøndsted, Hans Lennernäs, Finn Norring Christensen and Anette Müllertz, et al. |
| 190-196 | Metal-Catalyzed Oxidation of Brain-Derived Neurotrophic Factor (BDNF): Analytical Challenges for the Identification of Modified Sites | Jana L. Jensen, Carl Kolvenbach, Suzanne Roy and Christian Schöneich |
| 197-204 | Oxidation of the N-Terminal Gly-Residue of Peptides: Stress Study of Pexiganan Acetate in a Drug Formulation | Binyamin Feibush and Bradley C. Snyder |
| 205-208 | Apparent Lack of Effect of P-Glycoprotein on the Gastrointestinal Absorption of a Substrate, Tacrolimus, in Normal Mice | Win L. Chiou, Sang M. Chung and Ta C. Wu |
| 209-215 | Atorvastatin Transport in the Caco-2 Cell Model: Contributions of P-Glycoprotein and the Proton-Monocarboxylic Acid Co-Transporter | Xiaochun Wu, Lloyd R. Whitfield and Barbra H. Stewart |
| 216-221 | Structure Activity Relationship of Human Microsomal Epoxide Hydrolase Inhibition by Amide and Acid Analogues of Valproic Acid | Ofer Spiegelstein, Deanna L. Kroetz, René H. Levy, Boris Yagen and Sussan I. Hurst, et al. |
| 222-228 | Nasal Epithelial Permeation of Thymotrinan (TP3) Versus Thymocartin (TP4): Competitive Metabolism and Self-Enhancement | M. Christiane Schmidt, Werner Rubas and Hans P. Merkle |
| 229-235 | Histone H1-Mediated Transfection: Serum Inhibition Can Be Overcome by Ca2+ Ions | Annekathrin Haberland, Thomas Knaus, Sergei V. Zaitsev, Bernd Buchberger and Andreas Lun, et al. |
| 236-241 | Transepithelial Transport of Levofloxacin in the Isolated Perfused Rat Kidney | Tatsuya Ito, Ikuko Yano, Yukiya Hashimoto and Ken-ichi Inui |
| 242-246 | Development and Characterization of a Rapid and Comprehensive Genotyping Assay to Detect the Most Common Variants in Cytochrome P450 2D6 | Lisa A. Scarlett, Soraya Madani, Danny D. Shen and Rodney J. Y. Ho |
| 247-250 | Book Reviews |
| 251 | Pharmaceutical Research: A Quality Journal on a Mission | Vincent H. L. Lee |
| 252-256 | Clinical Trial Simulation in Drug Development | Peter L. Bonate |
| 257-265 | Principles and Application of Ultrasound in Pharmaceutical Powder Compression | Marina Levina, Michael H. Rubinstein and Ali R. Rajabi-Siahboomi |
| 266-274 | Transport Across the Primate Blood-Brain Barrier of a Genetically Engineered Chimeric Monoclonal Antibody to the Human Insulin Receptor | M. Josephina Coloma, Hwa Jeong Lee, Atsushi Kurihara, Elliot M. Landaw and Ruben J. Boado, et al. |
| 275-283 | Novel Lipid-Based Hollow-Porous Microparticles as a Platform for Immunoglobulin Delivery to the Respiratory Tract | Adrian I. Bot, Thomas E. Tarara, Dan J. Smith, Simona R. Bot and Catherine M. Woods, et al. |
| 284-290 | Regional Differences in Intestinal Spreading and pH Recovery and the Impact on Salmon Calcitonin Absorption in Dogs | Yong-Hee Lee, Barbara A. Perry, John P. Sutyak, William Stern and Patrick J. Sinko |
| 291-298 | Route-Dependent Metabolism of Morphine in the Vascularly Perfused Rat Small Intestine Preparation | Margaret M. Doherty and K. Sandy Pang |
| 299-305 | Persistent Inhibition of CYP3A4 by Ketoconazole in Modified Caco-2 Cells | Megan A. Gibbs, Mark T. Baillie, Danny D. Shen, Kent L. Kunze and Kenneth E. Thummel |
| 306-313 | In Vivo Gene Delivery to the Liver Using Novel Galactosylated Cationic Liposomes | Shigeru Kawakami, Shintaro Fumoto, Makiya Nishikawa, Fumiyoshi Yamashita and Mitsuru Hashida |
| 314-320 | A Cationic Lipid Emulsion/DNA Complex as a Physically Stable and Serum-Resistant Gene Delivery System | Sun Woo Yi, Tae Young Yune, Tae Woo Kim, Hesson Chung and Young Wook Choi, et al. |
| 321-327 | Mechanism-Based Modeling of Functional Adaptation Upon Chronic Treatment with Midazolam | Adriaan Cleton, Jonas Ödman, Piet Hein Van der Graaf, Wim Ghijsen and Rob Voskuyl, et al. |
| 328-335 | Population Pharmacokinetic/ Pharmacodynamic Modeling of Cetrorelix, a Novel LH-RH Antagonist, and Testosterone in Rats and Dogs | Martin Schwahn, Nelamangala V. Nagaraja and Hartmut Derendorf |
| 336-343 | Quantitative Prediction of In Vivo Drug-Drug Interactions from In Vitro Data Based on Physiological Pharmacokinetics: Use of Maximum Unbound Concentration of Inhibitor at the Inlet to the Liver | Shin-ichi Kanamitsu, Kiyomi Ito and Yuichi Sugiyama |
| 344-350 | Liposomes as Formulation Excipients for Protein Pharmaceuticals: A Model Protein Study | Sathyamangalam V. Balasubramanian, Jeremy Bruenn and Robert M. Straubinger |
| 351-357 | Stabilization of Proteins Encapsulated in Cylindrical Poly(lactide-co-glycolide) Implants: Mechanism of Stabilization by Basic Additives | Gaozhong Zhu and Steven P. Schwendeman |
| 358-365 | Predicting the Free Energies of Complexation Between Cyclodextrins and Guest Molecules: Linear versus Nonlinear Models | Christian Th. Klein, Diether Polheim, Helmut Viernstein and Peter Wolschann |
| 366-370 | Acid-Catalyzed Inversion of Sucrose in the Amorphous State at Very Low Levels of Residual Water | Evgenyi Y. Shalaev, Qun Lu, Maria Shalaeva and George Zografi |
| 371-372 | AAPS Electronic Scientist AAPS Electronic Scientist |
| 373-374 | News from the National Institute of General Medical Sciences (NIGMS) | Peter C. Preusch |
| 375-380 | Subject-by-Formulation Interaction in Bioequivalence: Conceptual and Statistical Issues | Walter W. Hauck, Terry Hyslop, Mei-Ling Chen, Rabindra Patnaik and Roger L. Williams |
| 381-384 | Bioequivalence of Methylphenidate Immediate-Release Tablets Using a Replicated Study Design to Characterize Intrasubject Variability | Marvin C. Meyer, Arthur B. Straughn, Eric J. Jarvi, Kennerly S. Patrick and Francis R. Pelsor, et al. |
| 385-390 | Pharmacokinetics of a Hematoregulatory Peptide (SK&F 107647) in Healthy Male Volunteers and in Patients with Colorectal or Pancreatic Adenocarcinoma Not Amenable to Standard Therapy | Parnian Zia-Amirhosseini, Robert Z. Harris, Hugh C. Cowley, Juan W. Valle and David R. Citerone, et al. |
| 391-396 | Stability of Human Serum Albumin During Bioprocessing: Denaturation and Aggregation During Processing of Albumin Paste | Jen-Jen Lin, Jeffrey D. Meyer, John F. Carpenter and Mark C. Manning |
| 397-404 | What is the True Solubility Advantage for Amorphous Pharmaceuticals? | Bruno C. Hancock and Michael Parks |
| 405-409 | Photomechanical Drug Delivery into Bacterial Biofilms | Nikolaos S. Soukos, Sigmund S. Socransky, Stephen E. Mulholland, Shun Lee and Apostolos G. Doukas |
| 410-418 | Allometric Pharmacokinetic Scaling: Towards the Prediction of Human Oral Pharmacokinetics | Meihua Rose Feng, Xiaochun Lou, Richard R. Brown and Athiwat Hutchaleelaha |
| 419-426 | Prediction of In Vivo Interaction Between Triazolam and Erythromycin Based on In Vitro Studies Using Human Liver Microsomes and Recombinant Human CYP3A4 | Shin-ichi Kanamitsu, Kiyomi Ito, Carol E. Green, Charles A. Tyson and Noriaki Shimada, et al. |
| 427-431 | The Stereoselective Distribution of Halofantrine Enantiomers Within Human, Dog, and Rat Plasma Lipoproteins | Dion R. Brocks, Manisha Ramaswamy, Aaron I. MacInnes and Kishor M. Wasan |
| 432-438 | Pharmacokinetic Study of the Hepatobiliary Transport of Indomethacin | Hirokazu Kouzuki, Hiroshi Suzuki and Yuichi Sugiyama |
| 439-444 | Dissolution Testing as a Prognostic Tool for Oral Drug Absorption: Dissolution Behavior of Glibenclamide | Raimar Löbenberg, Johannes Krämer, Vinod P. Shah, Gordon L. Amidon and Jennifer B. Dressman |
| 445-450 | Effect of the Concurrent LHRH Antagonist Administration with a LHRH Superagonist in Rats | Janusz W. Kostanski, Bhas A. Dani, Bruce Schrier and Patrick P. DeLuca |
| 451-459 | Synthetic Glycopeptide-Based Delivery Systems for Systemic Gene Targeting to Hepatocytes | Khursheed Anwer, Mark Logan, Frank Tagliaferri, Manpreet Wadhwa and Oscar Monera, et al. |
| 460-465 | Formation of Multilayers in the Caco-2 Cell Culture Model: A Confocal Laser Scanning Microscopy Study | Barbara Rothen-Rutishauser, Annette Braun, Maja Günthert and Heidi Wunderli-Allenspach |
| 466-470 | Transdermal Extraction of Analytes Using Low-Frequency Ultrasound | Samir Mitragotri, Matthew Coleman, Joseph Kost and Robert Langer |
| 471-475 | Visualization and Analysis of Electroosmotic Flow in Hairless Mouse Skin | Bradley D. Bath, Henry S. White and Erik R. Scott |
| 476-478 | Iontophoresis-Enhanced Absorptive Flux of Polar Molecules Across Intestinal Tissue In Vitro | Maurice Leonard, Elizabeth Creed, David Brayden and Alan W. Baird |
| 479-481 | Role of P-Glycoprotein in Ocular Clearance of Rhodamine 123 in Rabbits | Tetsu Kajikawa, Hiromu K. Mishima, Teruo Murakami and Mikihisa Takano |
| 482-485 | In Vivo Absorption Properties of Orally Administered Recombinant Human Interleukin-11 | Chih-Ming Leo Tseng, Leo Albert, Ron L. Peterson, Page Bouchard and Andrew J. Dorner, et al. |
| 486-489 | Solid State NMR Investigations on Nanosized Carrier Systems | Christian Mayer and Gerold Lukowski |
| 490-493 | Effect of the Storage Conditions on the Tensile Strength of Tablets in Relation to the Enthalpy Relaxation of the Binder | F. Kiekens, R. Zelko and J. P. Remon |
| 494-495 | AAPS Electronic Scientist |
| 497-504 | Growth Factor Delivery for Tissue Engineering | Julia E. Babensee, Larry V. McIntire and Antonios G. Mikos |
| 505-514 | The Influence of Cytotoxicity of Macromolecules and of VEGF Gene Modulated Vascular Permeability on the Enhanced Permeability and Retention Effect in Resistant Solid Tumors | Tamara Minko, Pavla Kopečkova, Vitaliy Pozharov, Keith D. Jensen and Jindřich Kopeček |
| 515-520 | Induction of Apoptosis in WEHI 231 Cells by Cationic Liposomes | Yukihiko Aramaki, Shuhei Takano, Hidetoshi Arima and Seishi Tsuchiya |
| 521-525 | Oxygen Radical-Mediated Pulmonary Toxicity Induced by Some Cationic Liposomes | Sujatha Dokka, David Toledo, Xianglin Shi, Vincent Castranova and Yon Rojanasakul |
| 526-532 | Differential Recognition of ACE Inhibitors in Xenopus Laevis Oocytes Expressing Rat PEPT1 and PEPT2 | Tong Zhu, Xing-Zhen Chen, Angela Steel, Matthias A. Hediger and David E. Smith |
| 533-538 | Role of P-Glycoprotein in Restricting Propranolol Transport in Cultured Rabbit Conjunctival Epithelial Cell Layers | Johnny J. Yang, Kwang-Jin Kim and Vincent H. L. Lee |
| 539-545 | Transepithelial Transport of Diphenhydramine Across Monolayers of the Human Intestinal Epithelial Cell Line Caco-2 | Hiroshi Mizuuchi, Toshiya Katsura, Yukiya Hashimoto and Ken-ichi Inui |
| 546-552 | Biliary Excretion of 17β-Estradiol 17β-d-Glucuronide Is Predominantly Mediated by cMOAT/MRP2 | Akiko Morikawa, Yasumasa Goto, Hiroshi Suzuki, Tomoko Hirohashi and Yuichi Sugiyama |
| 553-564 | Physiological Modeling of Altered Pharmacokinetics of a Novel Anticancer Drug, UCN-01 (7-Hydroxystaurosporine), Caused by Slow Dissociation of UCN-01 from Human α1-Acid Glycoprotein | Eiichi Fuse, Akitoshi Hashimoto, Natsuko Sato, Hiromi Tanii and Takashi Kuwabara, et al. |
| 565-571 | Propiverine-Induced Parkinsonism: A Case Report and a Pharmacokinetic/Pharmacodynamic Study in Mice | Hirotami Matsuo, Akiko Matsui, Risa Nasu, Hitomi Takanaga and Naohide Inoue, et al. |
| 572-582 | Bioequivalence Study of Stressed and Nonstressed Hard Gelatin Capsules Using Amoxicillin as a Drug Marker and Gamma Scintigraphy to Confirm Time and GI Location of In Vivo Capsule Rupture | G. A. Digenis, E. P. Sandefer, R. C. Page, W. J. Doll and T. B. Gold, et al. |
| 583-588 | Sensitivity of Empirical Metrics of Rate of Absorption in Bioequivalence Studies | Arne Ring, Laszlo Tothfalusi, Laszlo Endrenyi and Michael Weiss |
| 589-592 | Pharmacokinetic Variability and Therapeutic Drug Monitoring Actions at Steady State | Murali Ramanathan |
| 593-599 | Pharmacologic Response of a Controlled-Release PLGA Formulation for the Alpha-Melanocyte Stimulating Hormone Analog, Melanotan-I | Renu Bhardwaj, Mac E. Hadley, Robert T. Dorr, Katarina Dvorakova and Christine Brooks, et al. |
| 600-606 | Subcutaneous Administration of Superoxide Dismutase Entrapped in Long Circulating Liposomes: In Vivo Fate and Therapeutic Activity in an Inflammation Model | M. Luísa Corvo, Otto C. Boerman, Wim J. G. Oyen, Joáo C. S. Jorge and M. Eugénia M. Cruz, et al. |
| 607-611 | Methotrexate Esters of Poly(Ethylene Oxide)-Block-Poly(2-Hydroxyethyl-L-Aspartamide). Part I: Effects of the Level of Methotrexate Conjugation on the Stability of Micelles and on Drug Release | Yu Li and Glen S. Kwon |
| 612-618 | Mechanistic Studies on Surfactant-Induced Membrane Permeability Enhancement | Wei J. Xia and Hayat Onyuksel |
| 619-624 | Nuclear Magnetic Resonance and Infrared Spectroscopic Analysis of Nedocromil Hydrates | Linna R. Chen, Brian E. Padden, Sudha R. Vippagunta, Eric J. Munson and David J. W. Grant |
| 625-631 | Assessment of Polymer-Polymer Interactions in Blends of HPMC and Film Forming Polymers by Modulated Temperature Differential Scanning Calorimetry | Nasser Nyamweya and Stephen W. Hoag |
| 632-637 | A Rapid Spectrofluorimetric Technique for Determining Drug-Serum Protein Binding Suitable for High-Throughput Screening | Hemanshu H. Parikh, Kate McElwain, Vandana Balasubramanian, Winsy Leung and Diane Wong, et al. |
| 639-644 | Predicting Human Oral Bioavailability of a Compound: Development of a Novel Quantitative Structure-Bioavailability Relationship | C.Webster Andrews, Lee Bennett and Lawrence X. Yu |
| 645-652 | New Insights into the Pharmacokinetics and Metabolism of (R,S)-Ifosfamide in Cancer Patients Using a Population Pharmacokinetic-Metabolism Model | MarikaPasternyk Di Marco, Irving W. Wainer, Camille L. Granvil, Gerald Batist and Murray P. Ducharme |
| 653-659 | Pharmacokinetic-Pharmacodynamic Analysis of the EEG Effect of Alfentanil in Rats Followingβ-Funaltrexamine-Induced μOpioid Receptor “Knockdown”In Vivo | >Maria Garrido, Josy Gubbens-Stibbe, Erica Tukker, Eugégne Cox and Jacobien von Frijtag, et al. |
| 660-663 | Prediction of In Vivo Tissue Distribution from In Vitro Data 1. Experiments with Markers of Aqueous Spaces | Peter Ballard, David E. Leahy and Malcolm Rowland |
| 664-669 | Permeability and Diffusion in Vitreous Humor: Implications for Drug Delivery | Jing Xu, Jeffrey J. Heys, Victor H. Barocas and Theodore W. Randolph |
| 664-669 | Controlled Release of Liposomes from Biodegradable Dextran Microspheres: A Novel Delivery Concept | Robert J. H. Stenekes, Arjen E. Loebis, Catarina M. Fernandes, Daan J. A. Crommelin and Wim E. Hennink |
| 670-676 | Air-Interface Condition Promotes the Formation of Tight Corneal Epithelial Cell Layers for Drug Transport Studies | Joan-En Chang, Sujit K. Basu and Vincent H. L. Lee |
| 677-683 | Stabilization of Vinca Alkaloids Encapsulated in Poly(lactide-co-glycolide) Microspheres | Julia Marinina, Anna Shenderova, Susan R. Mallery and Steven P. Schwendeman |
| 684-689 | Preparation of Biodegradable Insulin Nanocapsules from Biocompatible Microemulsions | Suchat Watnasirichaikul, Nigel M. Davies, Thomas Rades and Ian G. Tucker |
| 696-700 | An Evaluation of the Use of Modulated Temperature DSC as a Means of Assessing the Relaxation Behaviour of Amorphous Lactose | Duncan Q. M. Craig, Merete Barsnes, Paul G. Royall and Vicky L. Kett |
| 701-706 | Simultaneous Determination of the Heat and the Quantity of Vapor Sorption Using a Novel Microcalorimetric Method | Vesa-Pekka Lehto and Ensio Lain |
| 707-714 | Polyisobutylcyanoacrylate Nanocapsules Containing an Aqueous Core as a Novel Colloidal Carrier for the Delivery of Oligonucleotides | Gregory Lambert, Elias Fattal, Huguette Pinto-Alphandary, Annette Gulik and Patrick Couvreur |
| 715-719 | Synthesis and Cytotoxic Evaluation of a Series of γ-Substituted γ-Aryloxymethyl-α-methylene-γ-butyrolactones Against Cancer Cells | Cheng-Chyi Tzeng, Kuan-Han Lee, Tai-Chi Wang, Chein-Hwa Han and Yeh-Long Chen |
| 720-726 | Induction of T Cell Anergy by Liposomes with Incorporated Major Histocompatibility Complex (MHC) II/Peptide Complexes | Annemiek J. M. L. van Rensen, Leonie S. Taams, Mayken C. Grosfeld-Stulemeyer, Willem van Eden and Daan J. A. Crommelin, et al. |
| 727-732 | 2D and 3D QSAR Analysis of Some Valproic Acid Metabolites and Analogues as Anticonvulsant Agents | Tatiana Netzeva, Irini Doytchinova and Roumiana Natcheva |
| 733-736 | The Effect of Nasal Patency on the Clearance of Radiolabeled Saline in Healthy Volunteers | Neena Washington, Julian A. McGlashan, Sarah J. Jackson, Deborah Bush and Kendal G. Pitt, et al. |
| 737-742 | Transfer of Dopamine in the Olfactory Pathway Following Nasal Administration in Mice | Maria Dahlin, Ulrika Bergman, Björn Jansson, Erik Björk and Eva Brittebo |
| 743-748 | Biovector™ Nanoparticles Improve Antinociceptive Efficacy of Nasal Morphine | Didier Betbeder, Sandrine Spérandio, Jean-Philippe Latapie, Josette de Nadaí and Alain Etienne, et al. |
| 749-753 | Morphine Antinociception Is Enhanced in mdr1a Gene-Deficient Mice | Jian Zong and Gary M. Pollack |
| 754-760 | Permeation Studies In Vitro and In Vivo of Potential Radiopharmaceuticals with Affinity to Neuro Receptors | Matthias Friebe, Kayoshi Suda, Hartmut Spies, Rosmarie Syhre and Ralf Berger, et al. |
| 761-765 | Carrier-Mediated Transport of Macrolide Antimicrobial Agents Across Caco-2 Cell Monolayers | Hidetaka Saito, Yoshiki Fukasawa, Yoko Otsubo, Kenji Yamada and Hitoshi Sezaki, et al. |
| 767-775 | Injectable Chemotherapeutic Microspheres and Glioma I: Enhanced Survival Following Implantation into the Cavity Wall of Debulked Tumors | Dwaine F. Emerich, S. R. Winn, Yunhua Hu, Joanne Marsh and Pamela Snodgrass, et al. |
| 776-781 | Injectable Chemotherapeutic Microspheres and Glioma II: Enhanced Survival Following Implantation into Deep Inoperable Tumors | Dwaine F. Emerich, S. R. Winn, Pamela Snodgrass, Denise LaFreniere and Mary Agostino, et al. |
| 782-787 | Pharmacokinetics and Antitumor Effect of Doxorubicin Carried by Stealth and Remote Loading Proliposome | J. P. Wang, Y. Maitani, K. Takayama and T. Nagai |
| 788-795 | Transdermal Macromolecular Delivery: Real-Time Visualisation of Iontophoretic and Chemically Enhanced Transport Using Two-Photon Excitation Microscopy | Burrinder S. Grewal, Aarti Naik, William J. Irwin, Gert Gooris and Cees J. de Grauw, et al. |
| 796-802 | The Effect of Two Azones on the Lateral Lipid Organization of Human Stratum Corneum and Its Permeability | Gonneke S. K. Pilgram, A. Marjolein Engelsma-van Pelt, Henk K. Koerten and Joke A. Bouwstra |
| 803-810 | Creation of Polarized Cells Coexpressing CYP3A4, NADPH Cytochrome P450 Reductase and MDR1/P-glycoprotein | Cynthia Brimer, James T. Dalton, Zixin Zhu, John Schuetz and Kazuto Yasuda, et al. |
| 811-816 | Biodegradable Polyester, Poly[α-(4-Aminobutyl)-l-Glycolic Acid], as a Non-Toxic Gene Carrier | Yong-Beom Lim, Sang-Oh Han, Han-Uk Kong, Yah Lee and Jong-Sang Park, et al. |
| 817-824 | Proofs of the Structure of Lipid Coated Nanoparticles (SMBV™) Used as Drug Carriers | Ignacio De Miguel, Laurent Imbertie, Valerie Rieumajou, Michel Major and Roger Kravtzoff, et al. |
| 825-832 | Oral Absorption of Peptides Through the Cobalamin (Vitamin B12) Pathway in the Rat Intestine | Jochem Alsenz, Greg J. Russell-Jones, Steven Westwood, Bernard Levet-Trafit and P. Chris de Smidt |
| 833-838 | Functional Impairment of Sinusoidal Membrane Transport of Organic Cations in Rats with CCl4-Induced Hepatic Failure | Soon-Sun Hong, Suk-Jae Chung and Chang-Koo Shim |
| 839-843 | The Intestinal Uptake of Phenol from Micellar Systems Does Not Conform to the Aqueous Transfer Model | Prajakti A. Kothare and Cheryl L. Zimmerman |
| 844-850 | In Vivo Specific Binding Characteristics and Pharmacokinetics of a 1,4-Dihydropyridine Calcium Channel Antagonist in the Senescent Mouse Brain | Shinya Uchida, Shizuo Yamada, Yoshiharu Deguchi, Minoru Yamamoto and Ryohei Kimura |
| 851-858 | Chemical Pathways of Peptide Degradation. X: Effect of Metal-Catalyzed Oxidation on the Solution Structure of a Histidine-Containing Peptide Fragment of Human Relaxin | Mehrnaz Khossravi and Ronald T. Borchardt |
| 859-862 | The Solid State Oxidation of Methionine Containing Peptide: A Preliminary Study Using Time of Flight Secondary Ion Mass Spectrometry | Limin Sun and Joseph A. Gardella |
| 863-870 | Surface Composition of Spray-Dried Particles of Bovine Serum Albumin/Trehalose/Surfactant | Michael Adler, Michael Unger and Geoffrey Lee |
| 871-877 | Hydrogen Bonding and Electrostatic Interaction Contributions to the Interaction of a Cationic Drug with Polyaspartic Acid | Touraj Ehtezazi, Thirumala Govender and Snjezana Stolnik |
| 879-886 | Crystallization of Lactose from Carbopol Gels | Xian Ming Zeng, Gary P. Martin, Christopher Marriott and John Pritchard |
| 887-890 | The Discrimination of Drug Polymorphic Forms from Single Crystals Using Atomic Force Microscopy | Ardeshir Danesh, Xinyong Chen, Martyn C. Davies, Clive J. Roberts and Giles H. W. Sanders, et al. |
| 891-894 | A Comparison of the Solubility of Danazol in Human and Simulated Gastrointestinal Fluids | Betty Lomstein Pedersen, Anette Müllertz, Helle Brøndsted and Henning Gjelstrup Kristensen |
| 895-899 | Book Reviews |
| 900-901 | AAPS Electronic Scientist | Paul A. Clark |
| 903-905 | Potential Role of P-Glycoprotein in Affecting Hepatic Metabolism of Drugs | Win L. Chiou, Sang M. Chung and Ta C. Wu |
| 906-910 | Molecular Cloning of a Na+-Dependent Nucleoside Transporter1 from Rabbit Intestine | Karin M. Gerstin, Mark J. Dresser, Juan Wang and Kathleen M. Giacomini |
| 911-919 | An Economic Cost Analysis of Oral Ganciclovir Prophylaxis for the Prevention of CMV Disease | Gordon G. Liu and Joel Hay |
| 920-924 | Quantitative Correlation Between Initial Dissolution Rate and Heat of Solution of Drug | Katsuhide Terada, Harumi Kitano, Yasuo Yoshihashi and Etsuo Yonemochi |
| 925-929 | Temperature Dependence of Bimolecular Reactions Associated with Molecular Mobility in Lyophilized Formulations | Sumie Yoshioka, Yukio Aso and Shigeo Kojima |
| 930-936 | Effects of Lyophilization on the Physical Characteristics and Chemical Stability of Amorphous Quinapril Hydrochloride | Yushen Guo, Stephen R. Byrn and George Zografi |
| 936-941 | Thermodynamics of Binding of Neutral Molecules to Sulfobutyl Ether β-Cyclodextrins (SBE-β-CDs): The Effect of Total Degree of Substitution | V. Zia, R. A. Rajewski and V. J. Stella |
| 942-948 | Deformation Behaviors of Tolbutamide, Hydroxypropyl-β-Cyclodextrin, and Their Dispersions | Eero Suihko, Antti Poso, Ossi Korhonen, Jukka Gynther and Jarkko Ketolainen, et al. |
| 949-954 | Analysis of the Compression Mechanics of Pharmaceutical Agglomerates of Different Porosity and Composition Using the Adams and Kawakita Equations | Fredrik Nicklasson and Göran Alderborn |
| 955-961 | Respirable PLGA Microspheres Containing Rifampicin for the Treatment of Tuberculosis: Manufacture and Characterization | Patrick O'Hara and Anthony J. Hickey |
| 962-966 | The Effect of Gelatin Cross-Linking on the Bioequivalence of Hard and Soft Gelatin Acetaminophen Capsules | Marvin C. Meyer, Arthur B. Straughn, Ramakant M. Mhatre, Ajaz Hussain and Vinod P. Shah, et al. |
| 967-973 | Gene Transfer In Vitro and In Vivo by Cationic Lipids Is Not Significantly Affected by Levels of Supercoiling of a Reporter Plasmid | Danielle Bergan, Todd Galbraith and David L. Sloane |
| 974-977 | Effects of pH and Dose on Nasal Absorption of Scopolamine Hydrobromide in Human Subjects | Shamim Ahmed, Anthony P. Sileno, Jorge C. deMeireles, Ramneik Dua and Harish K. Pimplaskar, et al. |
| 978-984 | Enhancement of the Systemic and CNS Specific Delivery of L-Dopa by the Nasal Administration of Its Water Soluble Prodrugs | Huaihung Danny Kao, Ashraf Traboulsi, Soichi Itoh, Lewis Dittert and Anwar Hussain |
| 985-990 | Lectin-Mediated Drug Targeting: Selection of Valency, Sugar Type (Gal/Lac), and Spacer Length for Cluster Glycosides as Parameters to Distinguish Ligand Binding to C-Type Asialoglycoprotein Receptors and Galectins | Sabine André, Benoît Frisch, Herbert Kaltner, Débora Lima Desouza and Francis Schuber, et al. |
| 991-998 | Anionic PAMAM Dendrimers Rapidly Cross Adult Rat Intestine In Vitro: A Potential Oral Delivery System? | Ruedeekorn Wiwattanapatapee, Begoña Carreño-Gómez, Navid Malik and Ruth Duncan |
| 999-1006 | Inhibition of LDL Oxidation and Oxidized LDL-induced Cytotoxicity by Dihydropyridine Calcium Antagonists | Alex Sevanian, Lijiang Shen and Fulvio Ursini |
| 1007-1012 | Metabolism Kinetics of Beclomethasone Propionate Esters in Human Lung Homogenates | Kuncoro Foe, David J. Cutler, Kenneth F. Brown and J. Paul Seale |
| 1013-1018 | Estimation of Molecular Linear Free Energy Relationship Descriptors. 4. Correlation and Prediction of Cell Permeation | James A. Platts, Michael H. Abraham, Anne Hersey and Darko Butina |
| 1019-1025 | Influence of Stereoselective Pharmacokinetics in the Development and Predictability of an IVIVC for the Enantiomers of Metoprolol Tartrate | Nattee Sirisuth and Natalie D. Eddington |
| 1026-1029 | In Situ Determination of Partition and Diffusion Coefficients in the Lipid Bilayers of Stratum Corneum | Samir Mitragotri |
| 1030-1032 | Effects of Storage Conditions on the Free Volume of Polyvinylpyrrolidone: Comparison of Positron Lifetime Data with the Tensile Strength of Tablets | R. Zelkó, K. Süvegh, S. Marton and I. Rácz |
| 1033-1034 | AAPS Electronic Scientist |
| 1035-1048 | Caveolae: An Alternative Membrane Transport Compartment | Mark Gumbleton, Abedel-nasser G. Abulrob and Lee Campbell |
| 1049-1055 | The Yeast Two-hybrid System and Its Pharmaceutical Significance | Zeki Topcu and Katherine L. B. Borden |
| 1056-1061 | Glucose-responsive Gene Delivery In Pancreatic Islet Cells Via Recombinant Adeno-associated Viral Vectors | Ya-Wun Yang and Robert M. Kotin |
| 1062-1070 | Enhanced In Vitro Oligonucleotide and Plasmid DNA Transport by VP1 Virus-like Particles | S. Henke, A. Rohmann, W.M. Bertling, Th. Dingermann and A. Zimmer |
| 1071-1076 | Synchronized Release of Sulpiride and Sodium Decanoate from HPMC Matrices: A Rational Approach to Enhance Sulpiride Absorption in the Rat Intestine | Muhammad Baluom, Michael Friedman, Peter Assaf, Abdullah I. Haj-Yehia and Abraham Rubinstein |
| 1077-1084 | The Effect of Local Attachment of Cationized Antioxidant Enzymes on Experimental Colitis in the Rat | Sigal Blau, Ron Kohen, Paul Bass and Abraham Rubinstein |
| 1085-1091 | A Study on Structural and Diffusion Properties of Porcine Stratum Corneum Based on Very Small Angle Neutron Scattering Data | Georgia Ch. Charalambopoulou, Panagiotis Karamertzanis, Eustathios S. Kikkinides, Athanassios K. Stubos and Nick K. Kanellopoulos, et al. |
| 1092-1097 | Evaluation of a Human Bio-Engineered Skin Equivalent for Drug Permeation Studies | Charles Asbill, Nanhye Kim, Ayman El-Kattan, Kim Creek and Philip Wertz, et al. |
| 1098-1103 | Effect of Carbonate Salts on the Kinetics of Acid-Catalyzed Dimerization of Adefovir Dipivoxil | Lung-Chi Yuan, Terrence C. Dahl and Reza Oliyai |
| 1104-1109 | Study of the Hygroscopic Properties of Selected Pharmaceutical Aerosols Using Single Particle Levitation | Changgeng Peng, Albert H. L. Chow and Chak K. Chan |
| 1110-1117 | Determination of the Origin of Charge Heterogeneity in a Murine Monoclonal Antibody | Melissa Perkins, Rolf Theiler, Susan Lunte and Margit Jeschke |
| 1118-1123 | The Use of Fluorescence Resonance Energy Transfer to Study the Disintegration Kinetics of Liposomes Containing Lysolecithin and Oleic Acid in Rat Plasma | Maja Madörin, Peter van Hoogevest, Rolf Hilfiker and Hans Leuenberger |
| 1124-1132 | Near Infrared with Principal Component Analysis as a Novel Analytical Approach for Nanoparticle Technology | Irène Brigger, Pierre Chaminade, Didier Desmaële, Maria Teresa Peracchia and Jean d'Angelo, et al. |
| 1133-1137 | Impact of Carbohydrate Constituents on Moisture Sorption of Herbal Extracts | Kevin K. W. Chu and Albert H. L. Chow |
| 1138-1143 | Starch Acetates—Multifunctional Direct Compression Excipients | Ossi Korhonen, Pasi Raatikainen, Päivi Harjunen, Johanna Nakari and Eero Suihko, et al. |
| 1144-1147 | Applicability of Dielectric Measurements to the Adsorption of Beta Blockers onto a Pharmaceutical Grade Ion-exchange Resin | Laurent Marchal-Heussler, Natacha Colling, Emmanuelle Benoit, Philippe Maincent and Jacques Bessiere |
| 1148-1150 | Normalization of Stratum Corneum Barrier Function and Transepidermal Water Loss In Vivo | Yogeshvar N. Kalia, Ingo Alberti, Nabila Sekkat, Catherine Curdy and Aarti Naik, et al. |
| 1151-1154 | Combined Effect of Low-Frequency Ultrasound and Iontophoresis: Applications for Transdermal Heparin Delivery | Long Le, Joseph Kost and Samir Mitragotri |
| 1155-1157 | Kinetic Analysis of p-Aminohippurate Transport in the OK Kidney Epithelial Cell Line | Yasushi Habu, Ikuko Yano, Masahiro Okuda, Yukiya Hashimoto and Ken-ichi Inui |
| 1159-1167 | Protein Instability in Poly(Lactic-co-Glycolic Acid) Microparticles | Marco van de Weert, Wim E. Hennink and Wim Jiskoot |
| 1168-1174 | Mechanisms of Transport and Structure-Permeability Relationship of Sulfasalazine and Its Analogs in Caco-2 Cell Monolayers | Earvin Liang, John Proudfoot and Mehran Yazdanian |
| 1175-1180 | The Influence of Donor and Reservoir Additives on Caco-2 Permeability and Secretory Transport of HIV Protease Inhibitors and Other Lipophilic Compounds | Bruce J Aungst, Nhung H Nguyen, James P Bulgarelli and Kristi Oates-Lenz |
| 1181-1188 | Evaluation of the Caco-2 Monolayer as a Model Epithelium for Iontophoretic Transport | Maurice Leonard, Elizabeth Creed, David Brayden and Alan W Baird |
| 1189-1197 | Inhibitory Potencies of 1,4-dihydropyridine Calcium Antagonists to P-glycoprotein-Mediated Transport: Comparison with the Effects on CYP3A4 | Miki Katoh, Miki Nakajima, Hiroshi Yamazaki and Tsuyoshi Yokoi |
| 1198-1205 | Astrocytes Increase the Functional Expression of P-Glycoprotein in an In Vitro Model of The Blood-Brain Barrier | Pieter Jaap Gaillard, Inez Cornelia Johanna van der Sandt, Levina Helena Voorwinden, Dung Vu and Jette Lyngholm Nielsen, et al. |
| 1206-1211 | Nuclear Transport of Oligonucleotides in HepG2-cells Mediated by Protamine Sulfate and Negatively Charged Liposomes | C. Welz, W. Neuhuber, H. Schreier, M. Metzler and R. Repp, et al. |
| 1212-1219 | Intravenous Cereport (RMP-7) Enhances Delivery of Hydrophilic Chemotherapeutics and Increases Survival in Rats with Metastatic Tumors in the Brain | Dwaine F Emerich, Reginald L Dean, JoAnne Marsh, Melissa Pink and Denise Lafreniere, et al. |
| 1220-1227 | Pharmacokinetic-Pharmacodynamic Modelling of Morphine Transport Across the Blood-Brain Barrier as a Cause of the Antinociceptive Effect Delay in Rats—A Microdialysis Study | M. René Bouw, Marie Gårdmark and Margareta Hammarlund-Udenaes |
| 1228-1235 | A Population Analysis of Nebulized (R)-albuterol in Dogs Using a Novel Mixed Gut-Lung Absorption PK-PD Model | Barbara Auclair, Irving W. Wainer, Karen Fried, Patrick Koch and Thomas P. Jerussi, et al. |
| 1236-1242 | Biodistribution of Amphotericin B When Delivered Through Cholesterol Hemisuccinate Vesicles in Normal and A. Fumigatus Infected Mice | Sandeep Saxena and Prahlad C. Ghosh |
| 1243-1249 | Sciatic Nerve Blockade with Lipid-Protein-Sugar Particles Containing Bupivacaine | Daniel S. Kohane, Michael Lipp, Ramsey C. Kinney, Noah Lotan and Robert Langer |
| 1250-1258 | Niosomes and Polymeric Chitosan Based Vesicles Bearing Transferrin and Glucose Ligands for Drug Targeting | Christine Dufes, Andreas G. Schätzlein, Laurence Tetley, Alexander I. Gray and Dave G. Watson, et al. |
| 1259-1264 | Oral Delivery of New Heparin Derivatives in Rats | Yong-kyu Lee, Sun Hee Kim and Youngro Byun |
| 1265-1272 | A Strategy for Primary High Throughput Cytotoxicity Screening in Pharmaceutical Toxicology | Peter J Bugelski, Uzma Atif, Sarah Molton, Ilana Toeg and Peter G Lord, et al. |
| 1273-1277 | Rapid Non-Genomic Feedback Effects of Glucocorticoids on CRF-Induced ACTH Secretion in Rats | Burkhard Hinz and Rolf Hirschelmann |
| 1278-1283 | Confidence Interval Criteria for Assessment of Dose Proportionality | Brian P. Smith, Francois R. Vandenhende, Karl A. DeSante, Nagy A. Farid and Pamela A. Welch, et al. |
| 1284-1289 | Population Pharmacokinetics of Temozolomide in Cancer Patients | J. Frank Jen, David L. Cutler, Sudhakar M. Pai, Vijay K. Batra and Melton B. Affrime, et al. |
| 1290-1298 | Hydrophilic Matrices for Controlled Drug Delivery: An Improved Mathematical Model to Predict the Resulting Drug Release Kinetics (the “sequential Layer” Model) | J. Siepmann and N. A. Peppas |
| 1299-1308 | Investigating the Structure and properties of Hydrated Hydroxypropyl methylcellulose and Egg Albumin Matrices Containing Carbamazepine: EPR and NMR Study | Ifat Katzhendler, Karsten Mäder, Reuven Azoury and Michael Friedman |
| 1309-1315 | Characterization and In Vitro Methotrexate Release from Methotrexate/Gelatin Conjugates of Opposite Conjugate Bond Polarity | Bill J Bowman and Clyde M III Ofner |
| 1316-1322 | Freeze-Concentration Separates Proteins and Polymer Excipients Into Different Amorphous Phases | Ken-ichi Izutsu and Shigeo Kojima |
| 1323-1328 | Biodegradable PLGA Microspheres Loaded with Ganciclovir for Intraocular Administration. Encapsulation Technique, in Vitro Release Profiles, and Sterilization Process | Rocio Herrero-Vanrell and Loreto Ramirez |
| 1329-1332 | New Bicompartmental Structures Are Observed When Stearylamine is Mixed with Triglyceride Emulsions | Helder Teixeira, Catherine Dubernet, Véronique Rosilio, Simon Benita and Jean Lepault, et al. |
| 1333-1334 | Announcement: AAPS Electronic Scientist: October 2000 |
| 1335-1344 | Optimizing the Science of Drug Development: Opportunities for Better Candidate Selection and Accelerated Evaluation in Humans | Lawrence J Lesko, Malcolm Rowland, Carl C Peck and Terrence F Blaschke |
| 1345-1353 | Protein Kinases as Therapeutic Targets | Rajagopalan Sridhar, Olivia Hanson-Painton and Denise R. Cooper |
| 1354-1359 | Synergistic Effect of Enhancers for Transdermal Drug Delivery | Samir Mitragotri |
| 1360-1366 | Generation of Micro-Particles of Proteins for Aerosol Delivery Using High Pressure Modified Carbon Dioxide | Rana T Bustami, Hak-Kim Chan, Fariba Dehghani and Neil R Foster |
| 1367-1373 | Formation and Isolation of Spherical Fine Protein Microparticles Through Lyophilization of Protein-Poly(ethylene Glycol) Aqueous Mixture | Takahiro Morita, Yuji Horikiri, Hiroshi Yamahara, Takehiko Suzuki and Hiroyuki Yoshino |
| 1374-1382 | Protein Spray-Freeze Drying. Effect of Atomization Conditions on Particle Size and Stability | Henry R Costantino, Laleh Firouzabadian, Ken Hogeland, Chichih Wu and Chris Beganski, et al. |
| 1384-1389 | Use of Artificial Neural Networks to Predict Drug Dissolution Profiles and Evaluation of Network Performance Using Similarity Factor | Kok Khiang Peh, Chee Peng Lim, Siow San Quek and Kean Hock Khoh |
| 1389-1395 | An Increased Throughput Method for the Determination of Partition Coefficients | Laure Hitzel, Alan P Watt and Karen L Locker |
| 1396-1401 | Application of High Performance Liquid Chromatography Coupled with Ultraviolet Spectroscopy and Electrospray Mass Spectrometry to the Characterisation of Ellagitannins From Terminalia Macroptera Roots | Olga Silva, Elsa T Gomes, Jean-Luc Wolfender, Andrew Marston and Kurt Hostettmann |
| 1402-1407 | Dextran-Methylprednisolone Succinate as a Prodrug of Methylprednisolone: Immunosuppressive Effects After In Vivo Administration to Rats | Reza Mehvar and Dean A Hoganson |
| 1408-1413 | In Vivo Study of the Effect of Valpromide and Valnoctamide in the Pilocarpine Rat Model of Focal Epilepsy | Hilde Lindekens, Ilse Smolders, Ghous M Khan, Meir Bialer and Guy Ebinger, et al. |
| 1414-1419 | Does Epidermal Turnover Reduce Percutaneous Penetration? | Micaela B Reddy, Richard H Guy and Annette L Bunge |
| 1420-1425 | The in Vitro Cell Association of Invasin Coated Polylactide-Co-glycolide Nanoparticles | Gordon F Dawson and Gavin W Halbert |
| 1426-1431 | Absorption and Disposition of a Selective Aldosterone Receptor Antagonist, Eplerenone, in the Dog | Chyung S Cook, Liming Zhang and JuDee S Fischer |
| 1432-1436 | The Role of Metabolites in Bioequivalency Assessment. III. Highly Variable Drugs with Linear Kinetics and First-Pass Effect | Andre J Jackson |
| 1437-1438 | Physical Characterization of Large Porous Particles for Inhalation | Rajiv Gupta, R Vanbever, J Mintzes, J Nice and D Chen, et al. |
| 1439-1442 | Book Reviews. Particle-Lung Infections, Lung Biology in Health and Disease Series, Volume 143. Peter Gehr and Joachim Heyder, Eds. Marcel Dekker, Inc., 270 Madison Avenue, New York, NY 1006-0602, http://www.dekker.com, 2000. xxi, 802 pp., illustrations. 225.00. < b > Design and Analysis of Bioavailability and Bioequivalence Studies, Second Edition Revised and Expanded. < /b > Shein- | 1444-1445 | AAPS Electronic Scientist |
| 1447-1455 | Photodynamic Therapy of Skin Cancers: Sensitizers, Clinical Studies and Future Directives | Fernanda S. De Rosa and M.Vitória L. B. Bentley |
| 1456-1460 | Influence of Passive Permeability on Apparent P-glycoprotein Kinetics | Kimberley A. Lentz, Joseph W. Polli, Stephen A. Wring, Joan E. Humphreys and James E. Polli |
| 1461-1467 | Development of Novel Lipophilic Derivatives of DADLE (Leucine Enkephalin Analogue): Intestinal Permeability Characteristics of DADLE Derivatives in Rats | Tomomi Uchiyama, Atsushi Kotani, Hiroyuki Tatsumi, Takeshi Kishida and Aya Okamoto, et al. |
| 1468-1474 | Design and In Vivo Evaluation of An Oral Delivery System for Insulin | Michaela K. Marschütz, Paolo Caliceti and Andreas Bernkop-Schnürch |
| 1475-1481 | Drug Distribution in Human Skin Using Two Different In Vitro Test Systems: Comparison with In Vivo Data | Heike Wagner, Karl-Heinz Kostka, Claus-Michael Lehr and Ulrich F. Schaefer |
| 1482-1488 | Inhibition of Angiotensin II-Induced Inositol Phosphate Production by Triacid Nonpeptide Antagonists in CHO Cells Expressing Human AT1 Receptors | Patrick M. L. Vanderheyden, Ilse Verheijen, Frederik L. P. Fierens, Jean-Paul DeBacker and Georges Vauquelin |
| 1489-1493 | Dexamethasone Megadoses Stabilize Rat Liver Lysosomal Membranes by Non-Genomic and Genomic Effects | Burkhard Hinz and Rolf Hirschelmann |
| 1494-1502 | Safety, Toxicokinetics and Tissue Distribution of Long-Term Intravenous Liposomal Amphotericin B (ambisome®): A 91-day Study in Rats | Ihor Bekersky, Garry W. Boswell, Richard Hiles, Robert M. Fielding and Donald Buell, et al. |
| 1503-1510 | Pharmacokinetics and Safety of an Anti-Vascular Endothelial Growth Factor Aptamer (NX1838) Following Injection into the Vitreous Humor of Rhesus Monkeys | Daniel W. Drolet, Joyce Nelson, Christopher E. Tucker, Philip M. Zack and Kerry Nixon, et al. |
| 1511-1515 | Hepatic Disposition of Fexofenadine: Influence of the Transport Inhibitors Erythromycin and Dibromosulphothalein | Robert W. Milne, Linda A. Larsen, Klaus L. Jørgensen, Jesper Bastlund and Graham R. Stretch, et al. |
| 1516-1525 | A Human Physiologically-Based Model for Glycyrrhzic Acid, A Compound Subject to Presystemic Metabolism and Enterohepatic Cycling | Bart Ploeger, Tjeert Mensinga, Adriënne Sips, Jan Meulenbelt and Joost DeJongh |
| 1526-1530 | Characteristics of Choline Transport Across the Blood-Brain Barrier in Mice: Correlation with In Vitro Data | Hideyasu Murakami, Naoyuki Sawada, Noriko Koyabu, Hisakazu Ohtani and Yasufumi Sawada |
| 1531-1536 | A Population Approach to Enzyme Characterization and Identification: Application to Phenacetin O-Deethylation | Donna J. Belle, Barbara J. Ring, Sandra R. B. Allerheiligen, Michael A. Heathman and Lisa M. O'Brien, et al. |
| 1537-1545 | Job Matching in Pharmacy Labor Markets: A Study in Four States | Richard R. Cline and David A. Mott |
| 1546-1550 | Delivery of Soluble Tumor Necrosis Factor Receptor from In-Situ Forming PLGA Implants: In-Vivo | Rom E. Eliaz, David Wallach and Joseph Kost |
| 1551-1557 | Bioanalytical Method Validation—A Revisit with a Decade of Progress | Vinod P. Shah, Kamal K. Midha, John W. A. Findlay, Howard M. Hill and James D. Hulse, et al. |
| 1558-1559 | AAPS Electronic Scientist |
| 1560-1562 | Reviewers for Pharmaceutical Research November 1999 Through October 2000 |
| 1563-1566 | Author Index to Volume 17 (2000) |
| 1567-1570 | Subject Index to Volume 17 (2000) |
| 1-8 | Recognition by Macrophages and Liver Cells of Opsonized Phospholipid Vesicles and Phospholipid Headgroups | S. Moein Moghimi and A. Christy Hunter |
| 9-15 | Establishment of Bone Marrow-Derived Endothelial Cell Lines From ts-SV40 T-antigen Gene Transgenic Rats | Kenji Hattori, Mariko Muta, Masakazu Toi, Hisashi Iizasa and Machiko Shinsei, et al. |
| 16-22 | Characterization of the Amino Acid Transport of New Immortalized Choroid Plexus Epithelial Cell Lines: A Novel In Vitro System for Investigating Transport Functions at the Blood-Cerebrospinal Fluid Barrier | Takeo Kitazawa, Ken-ichi Hosoya, Masatomi Watanabe, Tadayuki Takashima and Sumio Ohtsuki, et al. |
| 23-28 | Extravasation of Poly(amidoamine) (pamam) Dendrimers Across Microvascular Network Endothelium | Mohamed El-Sayed, Mohammad F. Kiani, Mike D. Naimark, Ahmed H. Hikal and Hamidreza Ghandehari |
| 29-38 | Differences in the Intracellular Distribution of Acid-Sensitive Doxorubicin-Protein Conjugates in Comparison to Free and Liposomal Formulated Doxorubicin as Shown by Confocal Microscopy | Ulrich Beyer, Barbara Rothen-Rutishauser, Clemens Unger, Heidi Wunderli-Allenspach and Felix Kratz |
| 39-44 | A Human Lymphocyte Based Ex Vivo Assay to Study the Effect of Drugs on P-glycoprotein (p-Gp) Function1 | Dolly A Parasrampuria, Marianne V Lantz and Leslie Z Benet |
| 45-53 | Interaction of Bile Salt and Phospholipids with Bovine Submaxillary Mucin | Timothy Scott Wiedmann, Cinthia Deye and Deborah Kallick |
| 54-60 | Optimization of Lipid Composition in Cationic Emulsion as In Vitro and In Vivo Transfection Agents | Tae Woo Kim, Hesson Chung, Ick Chan Kwon, Ha Chin Sung and Seo Young Jeong |
| 61-66 | Topical Gene Transfer into Rat Skin Using Electroporation | Nathalie Dujardin, Patrick Van Deŕ Smissen and Véronique Préat |
| 67-74 | Pharmacokinetics of Plasmid DNA in the Rat | Brett E. Houk, Robin Martin, Günther Hochhaus and Jeffrey A. Hughes |
| 75-82 | Design and Power of A Population Pharmacokinetic Study | Peter I D Lee |
| 83-89 | Optimal Design of a Population Pharmacodynamic Experiment for Ivabradine | Stephen B Duffull, France Mentré and Leon Aarons |
| 90-97 | Effect of Initial Buffer Composition on pH Changes During Far-From-Equilibrium Freezing of Sodium Phosphate Buffer Solutions | Gerardo Gómez, Michael J Pikal and Naír Rodríguez-Hornedo |
| 98-103 | Detection of Low Levels of the Amorphous Phase in Crystalline Pharmaceutical Materials by Thermally Stimulated Current Spectrometry | Gopi M Venkatesh, Maria E Barnett, Charles Owusu-Fordjour and Marc Galop |
| 104-111 | Correlation of the Capacity Factor in Vesicular Electrokinetic Chromatography with the Octanol: Water Partition Coefficient for Charged and Neutral Analytes | J. L. Razak, B. J. Cutak, C. K. Larive and C. E. Lunte |
| 112-116 | The Application of Near Infrared Spectroscopy and Dynamic Vapor Sorption to Quantify Low Amorphous Contents of Crystalline Lactose | Sarah E Hogan and Graham Buckton |
| 117-124 | In Vitro Protein Release and Degradation of Poly-dl-lactide-poly(ethylene glycol) Microspheres with Entrapped Human Serum Albumin: Quantitative Evaluation of the Factors Involved in Protein Release Phases | Xiaohong Li, Xianmo Deng and Zhitang Huang |
| 125-128 | Fourier Transform Infrared (FTIR) Analysis of Volatile Compounds in Expired Gas for the Monitoring of Poisonings 1.Ethanol | Takashi Nishiyama, Ikuko Tsukamoto, Yoichi Shirakawa, Hisao Komatsu and Nobuhiro Maekawa, et al. |
| 129-130 | AAPS Electronic Scientist |
| 131-145 | Mass Spectrometry Innovations in Drug Discovery and Development | Damon I Papac and Zahra Shahrokh |
| 146-150 | A Novel Drug-Regulated Gene Expression System Based on the Nuclear Receptor Constitutive Androstane Receptor (CAR) | Paavo Honkakoski, Ilpo Jääskeläinen, Minna Kortelahti and Arto Urtti |
| 151-156 | Flurbiprofen Enantiomers Inhibit Inducible Nitric Oxide Synthase Expression in RAW 264.7 Macrophages | Burkhard Hinz, Kay Brune, Thomas Rau and Andreas Pahl |
| 157-165 | Studies on Agents with Mixed NO-Dependent and Calcium Channel Antagonistic Vasodilating Activities | Clara Cena, Sonja Visentin, Antonella Di Stilo, Donatella Boschi and Roberta Fruttero, et al. |
| 166-170 | Risedronate Pharmacokinetics and Intra- and Inter-Subject Variability Upon Single-Dose Intravenous and Oral Administration | David Y. Mitchell, William H. Barr, Rachelle A. Eusebio, Karen A. Pallone Stevens and Frank P. Duke, et al. |
| 171-176 | A Functional Assay for Quantitation of the Apparent Affinities of Ligands of P-Glycoprotein in Caco-2 Cells | Jinnian Gao, Osamu Murase, Richard L. Schowen, Jeffrey Aubé and Ronald T. Borchardt |
| 177-182 | Effects of Furanocoumarin Derivatives in Grapefruit Juice on Nifedipine Pharmacokinetics in Rats | Kiminori Mohri and Yoshihiro Uesawa |
| 183-190 | Screening of Multidrug-Resistance Sensitive Drugs by In Situ Brain Perfusion in P-Glycoprotein-Deficient Mice | Salvatore Cisternino, Christophe Rousselle, Claude Dagenais and Jean-Michel Scherrmann |
| 191-195 | Tyrphostin-8 Enhances Transferrin Receptor-Mediated Transcytosis in Caco-2 Cells and Increases Hypoglycemic Effect of Orally Administered Insulin-Transferrin Conjugate in Diabetic Rats | Cindy Q. Xia and Wei-Chiang Shen |
| 196-202 | Characterization of Murine Monoclonal Antibody to Tumor Necrosis Factor (TNF-MAb) Formulation for Freeze-Drying Cycle Development | Xinghang Ma, D. Q. Wang, Robert Bouffard and Alan MacKenzie |
| 203-210 | Assessing Tablet Bond Types from Structural Features that Affect Tablet Tensile Strength | Helena Olsson and Christer Nyström |
| 211-216 | Thiolated Polymers: Development and Evaluation of Transdermal Delivery Systems for Progesterone | Claudia Valenta, Alexandra Walzer, Andreas E. Clausen and Andreas Bernkop-Schnürch |
| 217-223 | Evaluation of Carboxymethylpullulan as a Novel Carrier for Targeting Immune Tissues | Kazuyoshi Masuda, Masahiro Sakagami, Kazutoshi Horie, Hideo Nogusa and Hiroshi Hamana, et al. |
| 224-233 | Use of Labor Economic Theory to Examine Hours Worked by Male and Female Pharmacists | David A. Mott |
| 234-237 | Degradation Kinetics of Oxycarbonyloxymethyl Prodrugs of Phosphonates in Solution | Lung-Chi Yuan, Terrence C. Dahl and Reza Oliyai |
| 238-242 | Relationship of Pharmacokinetically-Calculated Volumes of Distribution to the Physiologic Distribution of Liposomal Drugs in Tissues: Implications for the Characterization of Liposomal Formulations | Robert M. Fielding |
| 243-245 | Synergistic Effect of Indomethacin and Bleomycin on Tumor Growth Produced by Activating Antitumor Immunity | Ryo Matsushita, Kenji Hattori, Kaori Hayashi, Hisashi Iizasa and Fujio Ichimura, et al. |
| 246-249 | Nocodazole Treatment of CV-1 Cells Enhances Nuclear/Perinuclear Accumulation of Lipid-DNA Complexes and Increases Gene Expression | Jimmy Lindberg, Mary Ann M. Fernandez, J. Dezz Ropp and Sarah F. Hamm-Alvarez |
| 250-251 | AAPS Electronic Scientist |
| 253-255 | A Useful In Vitro Model for Transport Studies of Alveolar Epithelial Barrier | Kwang-Jin Kim, Zea Borok and Edward D. Crandall |
| 256-260 | Usefulness of the Kohlrausch-Williams-Watts Stretched Exponential Function to Describe Protein Aggregation in Lyophilized Formulations and the Temperature Dependence Near the Glass Transition Temperature | Sumie Yoshioka, Yukio Aso and Shigeo Kojima |
| 261-266 | Sodium Chloride Enhances the Storage and Conformational Stability of BDNF and PEG-BDNF | William J. Callahan, Linda O. Narhi, Andrew A. Kosky and Michael J. Treuheit |
| 267-273 | Investigation of Solid-State Reactions Using Variable Temperature X-Ray Powder Diffractrometry. I. Aspartame Hemihydrate | Suneel Rastogi, Marek Zakrzewski and Raj Suryanarayanan |
| 274-280 | Influence of Crystal Structure on the Tableting Properties of Sulfamerazine Polymorphs | Changquan Sun and David J. W. Grant |
| 281-286 | Compaction Properties of L-Lysine Salts | Changquan Sun and David J. W. Grant |
| 287-293 | Incorporation of the Model Drug Ubidecarenone into Solid Lipid Nanoparticles | Heike Bunjes, Markus Drechsler, Michel H. J. Koch and Kirsten Westesen |
| 294-298 | An Investigation into the Surface Deposition of Progesterone on Poly (d,l-) Lactic Acid Microspheres Using Micro-Thermal Analysis | Paul G. Royall, Vivienne L. Hill, Duncan Q. M. Craig, Duncan M. Price and Mike Reading |
| 299-303 | An In Situ Dissolution Study of Aspirin Crystal Planes (100) and (001) by Atomic Force Microscopy | Ardeshir Danesh, Simon D. Connell, Martyn C. Davies, Clive J. Roberts and Saul J. B. Tendler, et al. |
| 304-310 | Transport Properties of Ionic Drugs in the Ammonio Methacrylate Copolymer Membranes | Yi-Ming Sun, Shao-Chin Hsu and Juin-Yih Lai |
| 311-315 | Iontophoretic Delivery of 5-Aminolevulinic Acid (ALA): Effect of pH | Renata F. V. Lopez, M. Vitória L. B. Bentley, M. Begoña Delgado-Charro and Richard H. Guy |
| 316-322 | Formulation and Evaluation of a Folic Acid Receptor-Targeted Oral Vancomycin Liposomal Dosage Form | Keith E. Anderson, Lise A. Eliot, Bruce R. Stevenson and James A. Rogers |
| 323-328 | Novel Polymeric Micelles Based on the Amphiphilic Diblock Copolymer Poly(N-vinyl-2-pyrrolidone)-block-poly(D,L-lactide) | Amina Benahmed, Maxime Ranger and Jean-Christophe Leroux |
| 329-335 | Binding and Internalization of an LFA-1-Derived Cyclic Peptide by ICAM Receptors on Activated Lymphocyte: A Potential Ligand for Drug Targeting to ICAM-1-Expressing Cells | Helena Yusuf-Makagiansar and Teruna J. Siahaan |
| 336-343 | DRV Liposomal Bupivacaine: Preparation, Characterization, and In Vivo Evaluation in Mice | Gilbert J. Grant, Yechezkel Barenholz, Boris Piskoun, Mylarrao Bansinath and Herman Turndorf, et al. |
| 344-351 | Lyophilized Lecithin Based Oil-Water Microemulsions as a New and Low Toxic Delivery System for Amphotericin B | Marco Antonio Moreno, Paloma Frutos and Ma Paloma Ballesteros |
| 352-360 | Tetanus Toxoid Loaded Nanoparticles from Sulfobutylated Poly(Vinyl Alcohol)-Graft-Poly(Lactide-co-Glycolide): Evaluation of Antibody Response After Oral and Nasal Application in Mice | Tobias Jung, Walter Kamm, Armin Breitenbach, Klaus-Dieter Hungerer and Erika Hundt, et al. |
| 361-366 | Probe Calibration in Transient Microdialysis In Vivo | Peter M. Bungay, Robert L. Dedrick, Elizabeth Fox and Frank M. Balis |
| 367-373 | Dermal Pharmacokinetics of Microemulsion Formulations Determined by In Vivo Microdialysis | Mads Kreilgaard |
| 374-379 | Induction of UDP-Glucuronosyltransferase UGT1A1 by the Flavonoid Chrysin in Caco-2 Cells—Potential Role in Carcinogen Bioinactivation | Alema Galijatovic, Yoko Otake, U. Kristina Walle and Thomas Walle |
| 380-388 | Biorelevant Dissolution Testing to Predict the Plasma Profile of Lipophilic Drugs After Oral Administration | Eleftheria Nicolaides, Moira Symillides, Jennifer B. Dressman and Christos Reppas |
| 389-393 | Role of Biantennary Glycans and Genetic Variants of Human α1-Acid Glycoprotein in Enantioselective Binding of Basic Drugs as Studied by High Performance Frontal Analysis/capillary Electrophoresis | Yukihiro Kuroda, Yoko Kita, Akimasa Shibukawa and Terumichi Nakagawa |
| 394-397 | Variability in the Bioavailability of Phenytoin Capsules in Males and Females | Marvin C. Meyer, Arthur B. Straughn, Ramakant M. Mhatre, Vinod P. Shah and Mei-Ling Chen, et al. |
| 398-402 | Influence of Tailor-Made Additives on Etching Patterns of Acetaminophen Single Crystals | Tonglei Li, Kenneth R. Morris and Kinam Park |
| 403-407 | Cryopreservation Enables Long-Term Storage of 9-(2-Phosphonylmethoxy-ethyl) Adenine Prodrug-Loaded Reconstituted Lactosylated High-Density Lipoprotein | Remco L. A. de Vrueh, Theo J. C. van Berkel and Martin K. Bijsterbosch |
| 408-411 | Rapid and Sensitive Assay of Tumor Necrosis Factor-α Gene Transcription | Xiaoying Zhang, Jianping Ye, Liying Wang, Jiradej Manosroi and Xianglin Shi, et al. |
| 412-413 | AAPS Electronic Scientist |
| 415-426 | Nonlinear Dynamics and Chaos Theory: Concepts and Applications Relevant to Pharmacodynamics | Aristides Dokoumetzidis, Athanassios Iliadis and Panos Macheras |
| 427-431 | Water-Soluble and Low Molecular Weight Chitosan-Based Plasmid DNA Delivery | Minhyung Lee, Jae-Woon Nah, Youngmin Kwon, Jae Joon Koh and Kyung Soo Ko, et al. |
| 432-438 | Inhibition of P-Glycoprotein Transport Function by Grapefruit Juice Psoralen | Er-jia Wang, Christopher N. Casciano, Robert P. Clement and William W. Johnson |
| 439-445 | Up-Regulation of Carnitine Transporters Helps Maintain Tissue Carnitine Levels in Carnitine Deficiency Induced by Pivalic Acid | Noriko Okudaira, Masao Fujigaki, Takemi Nakayoshi, Izumi Komiya and Yuichi Sugiyama |
| 446-453 | Improving the Selectivity of HAV-Peptides in Modulating E-Cadherin-E-Cadherin Interactions in the Intercellular Junction of MDCK Cell Monolayers | Irwan T. Makagiansar, Mike Avery, Yongbo Hu, Kenneth L. Audus and Teruna J. Siahaan |
| 454-459 | Once-a-Day Oral Dosing Regimen of Cyclosporin A: Combined Therapy of Cyclosporin A Premicroemulsion Concentrates and Enteric Coated Solid-State Premicroemulsion Concentrates | Chong-Kook Kim, Hee-Jong Shin, Su-Geun Yang, Jae-Hyun Kim and Yu-Kyoung Oh |
| 460-466 | Monitoring the Intragastric Distribution of a Colloidal Drug Carrier Model by Magnetic Resonance Imaging | Henryk Faas, Werner Schwizer, Christine Feinle, Hans Lengsfeld and Chris de Smidt, et al. |
| 467-473 | Targeting of 3′-Azido 3′-Deoxythymidine (AZT)-Loaded Poly(Isohexylcyanoacrylate) Nanospheres to the Gastrointestinal Mucosa and Associated Lymphoid Tissues | Assia Dembri, Marie-Jeanne Montisci, Jean Charles Gantier, Hélène Chacun and Gilles Ponchel |
| 474-479 | Effect of Sucrose/Raffinose Mass Ratios on the Stability of Co-Lyophilized Protein During Storage Above the Tg | Paul Davidson and Wendell Q. Sun |
| 480-487 | A Study of the Effects of the Physical Characteristics of Microcrystalline Cellulose on Performance in Extrusion Spheronization | Paul W. S. Heng and Otilia M. Y. Koo |
| 488-493 | A Quantitative Assay of Telomerase Activity | Yuebo Gan, Jie Lu, Andy Johnson, M. Guillaume Wientjes and David E. Schuller, et al. |
| 494-499 | Effects of Topical Anandamide-Transport Inhibitors, AM404 and Olvanil, on Intraocular Pressure in Normotensive Rabbits | Krista Laine, Tomi Järvinen, Juha Savinainen, Jarmo T. Laitinen and David W. Pate, et al. |
| 500-509 | Assessment of Tear Concentrations on Therapeutic Drug Monitoring. II. Pharmacokinetic Analysis of Valproic Acid in Guinea Pig Serum, Cerebrospinal Fluid, and Tears | Shinji Sato, Shuji Kitagawa, Masaharu Nakajima, Kenji Shimada and Akira Honda, et al. |
| 510-519 | Rat and Rabbit Plasma Distribution of Free and Chylomicron-Associated BIRT 377, a Novel Small Molecule Antagonist of LFA-1-Mediated Cell Adhesion | Kishor M. Wasan, Manisha Ramaswamy, Lorilynne Holtorf, Andrew A. Jayaraj and David J. Hauss |
| 520-524 | Interaction Mechanism Between Indoxyl Sulfate, a Typical Uremic Toxin Bound to Site II, and Ligands Bound to Site I of Human Serum Albumin | Toshiaki Sakai, Keishi Yamasaki, Tomoko Sako, Ulrich Kragh-Hansen and Ayaka Suenaga, et al. |
| 525-530 | Influence of Drug Treatment on the Microacidity in Rat and Human Skin—An In Vitro Electron Spin Resonance Imaging Study | Christian Kroll, Werner Herrmann, Reinhard Stöβer, Hans-Hubert Borchert and Karsten Mäder |
| 531-536 | Synthesis and Study of 5′-Ester Prodrugs of N6-Cyclopentyladenosine, a Selective A1 Receptor Agonist | Alessandro Dalpiaz, Angelo Scatturin, Enea Menegatti, Fabrizio Bortolotti and Barbara Pavan, et al. |
| 537-543 | Population Pharmacokinetic-Pharmacodynamic Model of Craving in an Enforced Smoking Cessation Population: Indirect Response and Probabilistic Modeling | Roberto Gomeni, Vincenzo Teneggi, Laura Iavarone, Lisa Squassante and Alan Bye |
| 544-547 | Profound Effect of Plasma Protein Binding on the Polarized Transport of Furosemide and Verapamil in the Caco-2 Model | Sang M. Chung, Eun J. Park, Steven M. Swanson, Ta C. Wu and Win L. Chiou |
| 548-550 | Controlled Release of Insulin from Injectable Biodegradable Triblock Copolymer | Young Jin Kim, Suna Choi, Jae Joon Koh, Minhyung Lee and Kyung Soo Ko, et al. |
| 551-555 | Book Reviews |
| 557-564 | Colonic Drug Delivery: Prodrug Approach | V.R. Sinha and Rachna Kumria |
| 565-572 | Expression of Multidrug Resistance-Associated Protein (MRP) in Human Retinal Pigment Epithelial Cells and Its Interaction with BAPSG, a Novel Aldose Reductase Inhibitor | Jithan V. Aukunuru, Gangadhar Sunkara, Nagesh Bandi, Wallace B. Thoreson and Uday B. Kompella |
| 573-578 | Transport of Levofloxacin in the OK Kidney Epithelial Cell Line: Interaction with p-Aminohippurate Transport | Yumiko Matsuo, Ikuko Yano, Yasushi Habu, Toshiya Katsura and Yukiya Hashimoto, et al. |
| 579-586 | Physicochemical Parameters Responsible for the Affinity of Methotrexate Analogs for Rat Canalicular Multispecific Organic Anion Transporter (cMOAT/MRP2) | Yong–Hae Han, Yukio Kato, Masayuki Haramura, Masateru Ohta and Hiroharu Matsuoka, et al. |
| 587-592 | P-Glycoprotein Inhibition Leads to Enhanced Disruptive Effects by Anti-Microtubule Cytostatics at the In Vitro Blood-Brain Barrier | Inez C. J. van der Sandt, Pieter J. Gaillard, Heleen H. Voorwinden, Albertus G. de Boer and Douwe D. Breimer |
| 593-599 | Influence of a Microemulsion Vehicle on Cutaneous Bioequivalence of a Lipophilic Model Drug Assessed by Microdialysis and Pharmacodynamics | Mads Kreilgaard, Michiel J. B. Kemme, Jacobus Burggraaf, Rik C. Schoemaker and Adam F. Cohen |
| 600-607 | Synthesis, In Vitro Skin Permeation Studies, and PLS-Analysis of New Naproxen Derivatives | Horst Weber, Uta Steimer, Raimund Mannhold and Gabriele Cruciani |
| 608-614 | Mutual Inhibition of the Insulin Absorption-Enhancing Properties of Dodecylmaltoside and Dimethyl-β-cyclodextrin Following Nasal Administration | Fakhrul Ahsan, John J. Arnold, Elias Meezan and Dennis J. Pillion |
| 615-621 | CYP2C19 Genotype Related Effect of Omeprazole on Intragastric pH and Antimicrobial Stability | Tomoko Kita, Yusuke Tanigawara, Nobuo Aoyama, Takashi Hohda and Yoshie Saijoh, et al. |
| 622-631 | Inhibition of In Vitro Metabolism of Simvastatin by Itraconazole in Humans and Prediction of In Vivo Drug-Drug Interactions | Michi Ishigam, Minoru Uchiyama, Tomoko Kondo, Haruo Iwabuchi and Shin-ichi Inoue, et al. |
| 632-639 | Effect of Oxidative Stress on the Structure and Function of Human Serum Albumin | Makoto Anraku, Keishi Yamasaki, Toru Maruyama, Ulrich Kragh-Hansen and Masaki Otagiri |
| 640-645 | Development of Systems for Targeting the Regional Lymph Nodes for Diagnostic Imaging: In Vivo Behaviour of Colloidal PEG-Coated Magnetite Nanospheres in the Rat Following Interstitial Administration | L. Illum, A. E. Church, M. D. Butterworth, A. Arien and J. Whetstone, et al. |
| 646-651 | Relationship Between Physicochemical and Osteotropic Properties of Bisphosphonic Derivatives: Rational Design for Osteotropic Drug Delivery System (ODDS) | Hideki Hirabayashi, Taiji Sawamoto, Jiro Fujisaki, Yuji Tokunaga and Sumihisa Kimura, et al. |
| 652-655 | Development of a Generalized, Quantitative Physicochemical Model of CYP3A4 Inhibition for Use in Early Drug Discovery | R. J. Riley, A. J. Parker, S. Trigg and C. N. Manners |
| 656-661 | SEM Imaging Predicts Quality of Niosomes from Maltodextrin-Based Proniosomes | Almira I. Blazek–Welsh and David G. Rhodes |
| 662-666 | The Use of Inverse Phase Gas Chromatography to Measure the Surface Energy of Crystalline, Amorphous, and Recently Milled Lactose | Helen E. Newell, Graham Buckton, David A. Butler, Frank Thielmann and Daryl R. Williams |
| 667-673 | Effect of Cyclodextrin Charge on Complexation of Neutral and Charged Substrates: Comparison of (SBE)7M-β-CD to HP-β-CD | V. Zia, R. A. Rajewski and V. J. Stella |
| 674-681 | Microhardness and Dislocation Identification Studies on Paracetamol Single Crystals | Stuart Finnie, Korlakunte V. R. Prasad, David B. Sheen and John N. Sherwood |
| 682-688 | Polymorph Control of Sulfathiazole in Supercritical CO2 | A. Kordikowski, T. Shekunov and P. York |
| 689-693 | Study of the Breakup Under Shear of a New Thermally Reversible Water-in-Oil-in-Water (W/O/W) Multiple Emulsion | Laetitia Olivieri, Monique Seiller, Lev Bromberg, Eyal Ron and Patrick Couvreur, et al. |
| 694-701 | Lipophilicity Behaviour of the Zwitterionic Antihistamine Cetirizine in Phosphatidylcholine Liposomes/Water Systems | Georgette Plemper van Balen, Giulia Caron, Giuseppe Ermondi, Alessandra Pagliara and Teresa Grandi, et al. |
| 702-708 | The Apparent Lipophilicity of Quaternary Ammonium Ions Is Influenced by Galvani Potential Difference, Not Ion-Pairing: A Cyclic Voltammetry Study | Géraldine Bouchard, Pierre–Alain Carrupt, Bernard Testa, Véronique Gobry and Hubert H. Girault |
| 709-712 | The Preparation, Characterization, and Evaluation of Cationic Microparticles for DNA Vaccine Delivery | M. Briones, M. Singh, M. Ugozzoli, J. Kazzaz and S. Klakamp, et al. |
| 713-717 | Effects of Tacrolimus and Cyclosporin A on Peptide Transporter PEPT1 in Caco-2 Cells | Hideyuki Motohashi, Toshiya Katsura, Hideyuki Saito and Ken-ichi Inui |
| 718-719 | Errata |
| 721-727 | CYP2C19 Genotype and Pharmacokinetics of Three Proton Pump Inhibitors in Healthy Subjects | Toshiyuki Sakai, Nobuo Aoyama, Tomoko Kita, Toshiyuki Sakaeda and Kohshi Nishiguchi, et al. |
| 728-733 | Evaluation of the Bioequivalence of Highly-Variable Drugs and Drug Products | Laszlo Tothfalusi, Laszlo Endrenyi, Kamal K. Midha, Maureen J. Rawson and John W. Hubbard |
| 734-741 | Novel Direct Curve Comparison Metrics for Bioequivalence | James E. Polli and Angus M. McLean |
| 742-744 | Human Jejunal Permeability of Two Polar Drugs: Cimetidine and Ranitidine | Narushi Takamatsu, Ok-Nam Kim, Lynda S. Welage, Nasir M. Idkaidek and Yayoi Hayashi, et al. |
| 745-752 | Anti-Drug Antibodies as Drug Carriers. I. For Small Molecules | Bruce N. Rehlaender and Moo J. Cho |
| 753-760 | Antibodies as Drug Carriers. II. For Proteins | Bruce N. Rehlaender and Moo J. Cho |
| 761-770 | Simulation of the Delivery of Doxorubicin to Hepatoma | Yin-Min Felicia Goh, Hwai Loong Kong and Chi-Hwa Wang |
| 771-779 | Systemic Delivery of Cetrorelix to Rats by a New Aerosol Delivery System | Rosario Lizio, Thomas Klenner, Antonio Werner Sarlikiotis, Peter Romeis and Degenhard Marx, et al. |
| 780-787 | Host Factors Influencing the Preferential Localization of Sterically Stabilized Liposomes in Klebsiella Pneumoniae-Infected Rat Lung Tissue | R. M. Schiffelers, G. Storm and I. A. J. M. Bakker-Woudenberg |
| 788-793 | Size-Dependent Bioadhesion of Micro- and Nanoparticulate Carriers to the Inflamed Colonic Mucosa | Alf Lamprecht, Ulrich Schäfer and Claus-Michael Lehr |
| 794-799 | Glucose-Binding Property of Pegylated Concanavalin a | Jung Ju Kim and Kinam Park |
| 800-806 | HMG-CoA Reductase Inhibitors (Statins) Characterized as Direct Inhibitors of P-Glycoprotein | Er-jia Wang, Christopher N. Casciano, Robert P. Clement and William W. Johnson |
| 807-813 | PEPT2-Mediated Uptake of Neuropeptides in Rat Choroid Plexus | Nathan S. Teuscher, Richard F. Keep and David E. Smith |
| 814-822 | Excretion Into Gastrointestinal Tract of Irinotecan Lactone and Carboxylate Forms and Their Pharmacodynamics in Rodents | Kazuhiko Arimori, Noriaki Kuroki, Ayumi Kumamoto, Naomi Tanoue and Masahiro Nakano, et al. |
| 823-828 | Intestinal Absorption of Octreotide Using Trimethyl Chitosan Chloride: Studies in Pigs | Maya Thanou, J. Coos Verhoef, Jos H. M. Verheijden and Hans E. Junginger |
| 829-837 | Gastrointestinal Transit and Mucoadhesion of Colloidal Suspensions of Lycopersicon Esculentum L. and Lotus Tetragonolobus Lectin-PLA Microsphere Conjugates in Rats | Marie-Jeanne Montisci, Assia Dembri, Gaetana Giovannuci, Hélène Chacun and Dominique Duchêne, et al. |
| 838-845 | Altered Disposition and Effect of Lerisetron in Rats with Elevated Alpha1-acid Glycoprotein Levels | Nerea Jauregizar, Rosario Calvo, Elena Suarez, Antonio Quintana and Ewa Raczka, et al. |
| 846-851 | A Novel Topoisomerase II Poison GL331 Preferentially Induces DNA Cleavage at (C/G)T Sites and Can Cause Telomere DNA Damage | Chun-Chung Lee and Tze-Sing Huang |
| 852-858 | Characterization of Two Polymorphs of Salmeterol Xinafoate Crystallized From Supercritical Fluids | Henry H. Y. Tong, Boris Yu Shekunov, Peter York and Albert H. L. Chow |
| 859-866 | Ritonavir: An Extraordinary Example of Conformational Polymorphism | John Bauer, Stephen Spanton, Rodger Henry, John Quick and Walter Dziki, et al. |
| 867-872 | Fracture Property Studies of Paracetamol Single Crystals Using Microindentation Techniques | Korlakunte V. R. Prasad, David B. Sheen and John N. Sherwood |
| 873-877 | Compression Shear Strength and Tableting Behavior of Microcrystalline Cellulose Agglomerates Modulated by a Solution Binder (Polyethylene Glycol) | Fredrik Nicklasson and Göran Alderborn |
| 878-885 | Stabilization and Controlled Release of Bovine Serum Albumin Encapsulated in Poly(D, L-lactide) and Poly(ethylene glycol) Microsphere Blends | Wenlei Jiang and Steven P. Schwendeman |
| 886-893 | Enantioseparation of Flobufen with Cyclodextrins Studied by Capillary Electrophoresis and NMR | Alexandrine Lambert, Jean-Michel Ballon and Alain Nicolas |
| 894-896 | Magainin-Mediated Disruption of Stratum Corneum Lipid Vesicles | Shilpa Kaushik, Arthi Krishnan, Mark R. Prausnitz and Peter J. Ludovice |
| 897-898 | AAPS Electronic Scientist |
| 899-906 | Controlled Local Delivery of Interleukin-2 by Biodegradable Polymers Protects Animals from Experimental Brain Tumors and Liver Tumors | Justin Hanes, Allen Sills, Zhong Zhao, KwangWook Suh and Betty Tyler, et al. |
| 907-913 | Mdr1 Transfection Causes Enhanced Apoptosis by Paclitaxel: An Effect Independent of Drug Efflux Function of P-Glycoprotein | Dong Li and JessieL-S Au |
| 914-921 | LDL Induced Association of Anionic Liposomes with Cells and Delivery of Contents as Shown by the Increase in Potency of Liposome Dependent Drugs | Ketan Amin, Ka-Yun Ng, Carolyn S. Brown, Maria S. Bruno and Timothy D. Heath |
| 922-927 | Protamine Sulfate Enhances the Transduction Efficiency of Recombinant Adeno-Associated Virus-Mediated Gene Delivery | Ya-Wun Yang and Yuan-Chiao Hsieh |
| 928-936 | Interactions Between Oligonucleotides and Cationic Polymers Investigated by fluorescence Correlation Spectroscopy | Elsa Van Rompaey, Yves Engelborghs, Niek Sanders, Stefaan C. De Smedt and Joseph Demeester |
| 937-942 | The Mucosal Toxicity of Different Benzalkonium Chloride Analogues Evaluated with an Alternative Test Using Slugs | Els Adriaens, Kristof Dierckens, Tiene G. M. Bauters, Hans J. Nelis and Freddy van Goethem, et al. |
| 943-949 | A New Colorimetric Assay for Studying and Rapid Screening of Membrane Penetration Enhancers¥ | Damien Evrard, Elka Touitou, Sofiya Kolusheva, Yitzhak Fishov and Raz Jelinek |
| 950-956 | Targeting the Sodium-Dependent Multivitamin Transporter (SMVT) for Improving the Oral Absorption Properties of a Retro-Inverso Tat Nonapeptide | Srinivasan Ramanathan, Shahriar Pooyan, Stanley Stein, Puttur D. Prasad and Jihong Wang, et al. |
| 957-963 | Effect of mdr1a P-Glycoprotein Gene Disruption, Gender, and Substrate Concentration on Brain Uptake of Selected Compounds | Claude Dagenais, Jian Zong, Julie Ducharme and Gary M. Pollack |
| 964-970 | Oral Delivery of Biologically Active Parathyroid Hormone | Andrea Leone-Bay, Masahiko Sato, Duncan Paton, Ann H. Hunt and Donald Sarubbi, et al. |
| 971-979 | Receptor-Mediated Targeting of Spray-Dried Lipid Particles Coformulated with Immunoglobulin and Loaded with a Prototype Vaccine | Adrian I. Bot, Dan J. Smith, Simona Bot, Luis Dellamary and Thomas E. Tarara, et al. |
| 980-986 | Comparison of Tissue Concentrations After Intramuscular and Topical Administration of Ketoprofen | Irmgard Tegeder, Jörn Lötsch, Martina Kinzig-Schippers, Fritz Sörgel and Gary R. Kelm, et al. |
| 987-991 | Searching for Balanced Hybrid NO-Donor 1,4-Dihydropyridines with Basic Properties | Donatella Boschi, Giulia Caron, Sonja Visentin, Antonella Di Stilo and Barbara Rolando, et al. |
| 992-998 | Effect of Selective Lipid Extraction from Different Body Regions on Epidermal Barrier Function | Nancy A. Monteiro-Riviere, Alfred O. Inman, Vivien Mak, Philip Wertz and Jim E. Riviere |
| 999-1005 | Probing the Effect of Vehicles on Topical Delivery: Understanding the Basic Relationship Between Solvent and Solute Penetration Using Silicone Membranes | Sheree E. Cross, W.John Pugh, Jonathan Hadgraft and Michael S. Roberts |
| 1006-1011 | Supersaturation: Enhancement of Skin Penetration and Permeation of a Lipophilic Drug | Katrin Moser, Katrin Kriwet, Christiane Froehlich, Yogeshvar N. Kalia and Richard H. Guy |
| 1012-1017 | X-Ray Microanalysis of Cryopreserved Human Skin to Study the Effect of Iontophoresis on Percutaneous Ion Transport1 | Louk A. R. M. Pechtold, Harry E. Boddé, Hans E. Junginger, Henk K. Koerten and Joke A. Bouwstra |
| 1018-1023 | Effect of Bilayer Disruption on Transdermal Transport of Low-Molecular Weight Hydrophobic Solutes | Samir Mitragotri |
| 1024-1028 | Divergent Effects of Raloxifene HCl on the the Pharmacokinetics and Pharmacodynamics of Warfarin | Jeffrey W. Miller, Andrej Skerjanec, Mary P. Knadler, Atalanta Ghosh and Sandra R. B. Allerheiligen |
| 1029-1034 | Pharmacokinetics of the R- and S-Enantiomers of Oxybutynin and N-Desethyloxybutynin Following Oral and Transdermal Administration of the Racemate in Healthy Volunteers | R.Howard Zobrist, Bernhard Schmid, Alexander Feick, Danyi Quan and Steven W. Sanders |
| 1035-1041 | Cisplatin-Loaded Polymer-Metal Complex Micelle with Time-Modulated Decaying Property as a Novel Drug Delivery System | Nobuhiro Nishiyama, Yukio Kato, Yuichi Sugiyama and Kazunori Kataoka |
| 1042-1048 | Liposomes Bearing Polyethyleneglycol-Coupled Transferrin with Intracellular Targeting Property to the Solid Tumors In Vivo | Osamu Ishida, Kazuo Maruyama, Hiroyuki Tanahashi, Motoharu Iwatsuru and Katsunori Sasaki, et al. |
| 1049-1055 | Role of Genetic Algorithms and Artificial Neural Networks in Predicting the Phase Behavior of Colloidal Delivery Systems | Snezana Agatonovic-Kustrin and Raid G. Alany |
| 1056-1060 | Fractal Volume of Drug Distribution: It Scales Proportionally to Body Mass | Vangelis Karalis, Laurent Claret, Athanassios Iliadis and Panos Macheras |
| 1061-1067 | Modeling Heterogeneity of Particles and Random Effects in Drug Dissolution | Petr Lánský and Michael Weiss |
| 1068-1069 | AAPS Electronic Scientist |
| 1071-1080 | Optimizing Drug Development: Strategies to Assess Drug Metabolism/Transporter Interaction Potential—Toward a Consensus | Geoffrey T. Tucker, J. Brian Houston and Shiew-Mei Huang |
| 1081-1082 | The Measurement of Small Quantities of Amorphous Material—Should We Be Considering the Rigid Amorphous Fraction? | Duncan Q. M. Craig, Vicky L. Kett, John R. Murphy and Duncan M. Price |
| 1083-1090 | Sequential Processing of Human ProIL-1β by Caspase-1 and Subsequent Folding Determined by a Combined In Vitro and In Silico Approach | Peter W. Swaan, Daren L. Knoell, Freek Helsper and Mark D. Wewers |
| 1091-1095 | Receptor-Mediated Gene Targeting to Tissues In Vivo Following Intravenous Administration of Pegylated Immunoliposomes | Ningya Shi, Ruben J. Boado and William M. Pardridge |
| 1096-1101 | Inhibition of HIV-1 in Cell Culture by Oligonucleotide-Loaded Nanoparticles | Myriam Berton, Priscilla Turelli, Didier Trono, Cy Stein and Eric Allémann, et al. |
| 1102-1109 | Characterizing the Expression of CYP3A4 and Efflux Transporters (P-gp, MRP1, and MRP2) in CYP3A4-Transfected Caco-2 Cells After Induction with Sodium Butyrate and the Phorbol Ester 12-O-Tetradecanoylphorbol-13-Acetate | Carolyn L. Cummins, Lara M. Mangravite and Leslie Z. Benet |
| 1110-1118 | Transport of Peptidomimetic Thrombin Inhibitors with a 3-Amidino-Phenylalanine Structure: Permeability and Efflux Mechanism in Monolayers of a Human Intestinal Cell Line (Caco-2) | Walter Kamm, Jörg Hauptmann, Isabel Behrens, Jörg Stürzebecher and Frank Dullweber, et al. |
| 1119-1125 | Sinusoidal Efflux of Taurocholate Is Enhanced in Mrp2-Deficient Rat Liver | Hidetaka Akita, Hiroshi Suzuki and Yuichi Sugiyama |
| 1126-1130 | Mucosal Uptake of Gabapentin (Neurontin) vs. Pregabalin in the Small Intestine | Nusara Piyapolrungroj, Cheng Li, Howard Bockbrader, Guangyu Liu and David Fleisher |
| 1131-1137 | Intestinal First-Pass Metabolism of Eperisone in the Rat | Kiyoshi Mihara, Mina Matsumura, Eiji Yoshioka, Kazuhiko Hanada and Hiromitsu Nakasa, et al. |
| 1138-1145 | Transport of Lipophilic Drug Molecules in a New Mucus-Secreting Cell Culture Model Based on HT29-MTX Cells | Isabel Behrens, Patric Stenberg, Per Artursson and Thomas Kissel |
| 1146-1150 | The Effect of Polyethylene Glycol 400 on Gastrointestinal Transit: Implications for the Formulation of Poorly-Water Soluble Drugs | Abdul W. Basit, J. Michael Newton, Michael D. Short, Wendy A. Waddington and Peter J. Ell, et al. |
| 1151-1156 | Transdermal Delivery of Heparin and Low-Molecular Weight Heparin Using Low-Frequency Ultrasound | Samir Mitragotri and Joseph Kost |
| 1157-1166 | Long-Circulating PEGylated Polycyanoacrylate Nanoparticles as New Drug Carrier for Brain Delivery | Pilar Calvo, Bruno Gouritin, Hélène Chacun, Didier Desmaële and Jean D'Angelo, et al. |
| 1167-1173 | Inhibitory Effects of Novel Hydrophilic Cyclodextrin Derivatives on Nitric Oxide Production in Macrophages Stimulated with Lipopolysaccharide | Hidetoshi Arima, Yoji Nishimoto, Keiichi Motoyama, Fumitoshi Hirayama and Kaneto Uekama |
| 1174-1184 | A Pharmacokinetic Model to Predict the PK Interaction of L-Dopa and Benserazide in Rats | Susan Grange, Nicholas H. G. Holford and Theodor W. Guentert |
| 1185-1189 | Effects of Food on the Pharmacokinetics of Methylphenidate | K. K. Midha, G. McKay, M. J. Rawson, E. D. Korchinski and J. W. Hubbard |
| 1190-1202 | A Physiologically Based Pharmacokinetic Analysis of Capecitabine, a Triple Prodrug of 5-FU, in Humans: The Mechanism for Tumor-Selective Accumulation of 5-FU | Yuko Tsukamoto, Yukio Kato, Masako Ura, Ikuo Horii and Hideo Ishitsuka, et al. |
| 1203-1209 | Kinetic Analysis of the Disposition of Insulin-Like Growth Factor 1 in Healthy Volunteers | Naomi Mizuno, Yukio Kato, Masato Iwamoto, Akinori Urae and Toshiaki Amamoto, et al. |
| 1210-1219 | Modeling and Simulation for Clinical Trial Design Involving a Categorical Response: A Phase II Case Study with Naratriptan | Ivan Nestorov, Gordon Graham, Stephen Duffull, Leon Aarons and Eliane Fuseau, et al. |
| 1220-1225 | Power Spectral Analysis of Heart Rate Variability in Rats as a Quantitative Tool in the PK-PD Analysis of the Parasympatholytic Activity of Atropine | Itay Perlstein, David Stepensky, Dan Sapoznikov and Amnon Hoffman |
| 1226-1231 | Osmotic Properties of Sulfobutylether and Hydroxypropyl Cyclodextrins | Erika A. Zannou, William H. Streng and Valentino J. Stella |
| 1232-1236 | Enzymatic Activities in the Microsomes Prepared from Rat Small Intestinal Epithelial Cells by Differential Procedures | Kiminori Mohri and Yoshihiro Uesawa |
| 1237-1238 | AAPS Electronic Scientist |
| 1239-1246 | Progress in the Use of Biological Assays During the Development of Biotechnology Products | Anthony R. Mire-Sluis |
| 1247-1254 | Biofilm Consortia on Biomedical and Biological Surfaces: Delivery and Targeting Strategies | V. Sihorkar and S. P. Vyas |
| 1255-1261 | Ultrasound-Induced Hyperthermia Increases Cellular Uptake and Cytotoxicity of P-Glycoprotein Substrates in Multi-Drug Resistant Cells | Yang Liu, Cheong-Weon Cho, Xiangdong Yan, Thomas K. Henthorn and Kevin O. Lillehei, et al. |
| 1262-1269 | Functional Characterization of Human Organic Anion Transporting Polypeptide B (OATP-B) in Comparison with Liver-Specific OATP-C | Ikumi Tamai, Takashi Nozawa, Minako Koshida, Jun-ichi Nezu and Yoshimichi Sai, et al. |
| 1270-1276 | Enhanced Oral Bioavailability of 2′-β-fluoro-2′,3′-dideoxyadenosine (F-ddA) Through Local Inhibition of Intestinal Adenosine Deaminase | R. Tyler DeGraw and Bradley D. Anderson |
| 1277-1283 | Systemic Administration of TerplexDNA System: Pharmacokinetics and Gene Expression | Lei Yu, Hearan Suh, Jae Joon Koh and Sung Wan Kim |
| 1284-1290 | Preferential Binding of Polyethylene Glycol-Coated Liposomes Containing a Novel Cationic Lipid, TRX-20, to Human Subendthelial Cells via Chondroitin Sulfate | Takashi Harigai, M. Kondo, Masashi Isozaki, Hiroaki Kasukawa and Hitomi Hagiwara, et al. |
| 1291-1298 | Pharmacokinetics of Differently Designed Immunoliposome Formulations in Rats with Or Without Hepatic Colon Cancer Metastases | Gerben A. Koning, Henriëtte W. M. Morselt, Arko Gorter, Theresa M. Allen and Samuel Zalipsky, et al. |
| 1299-1304 | Comparison of the Lymphatic Transport of Halofantrine Administered in Disperse Systems Containing Three Different Unsaturated Fatty Acids | René Holm, Anette Müllertz, Gitte P. Pedersen and Henning G. Kristensen |
| 1305-1309 | The Effect of Serum Albumin on Amphotericin B Aggregate Structure and Activity | Scott C. Hartsel, Emily Bauer, Evan H. Kwong and Kishor M. Wasan |
| 1310-1314 | Penetration of Cefaclor Into the Interstitial Space Fluid of Skeletal Muscle and Lung Tissue in Rats | Amparo de la Penña, Teresa Dalla Costa, James D. Talton, Edelgard Rehak and Jens Gross, et al. |
| 1315-1319 | Respirable PLGA Microspheres Containing Rifampicin for the Treatment of Tuberculosis: Screening in An Infectious Disease Model | Sandra Suarez, Patrick O'Hara, Masha Kazantseva, Christian E. Newcomer and Roy Hopfer, et al. |
| 1320-1326 | Effect of Meropenem on Disposition Kinetics of Valproate and Its Metabolites in Rabbits | Koichi Yokogawa, Satsuki Iwashita, Akira Kubota, Youko Sasaki and Junko Ishizaki, et al. |
| 1327-1330 | The Enantioselective Binding of Mefloquine Enantiomers to P-glycoprotein Determined Using An Immobilized P-glycoprotein Liquid Chromatographic Stationary Phase | Lili Lu, Fabio Leonessa, Michael T. Baynham, Robert Clarke and Francois Gimenez, et al. |
| 1331-1335 | Drug-Drug Interactions Arising From the Use of Liposomal Vincristine in Combination with Other Anticancer Drugs | Dawn N. Waterhouse, Nancy Dos Santos, Lawrence D. Mayer and Marcel B. Bally |
| 1336-1344 | SB-239063, a Potent and Selective Inhibitor of P38 Map Kinase: Preclinical Pharmacokinetics and Species-Specific Reversible Isomerization | Keith W. Ward, Joel W. Proksch, Leonard M. Azzarano, Kevin L. Salyers and Jeanelle E. McSurdy-Freed, et al. |
| 1345-1353 | Effect of Moisture on the Stability of a Lyophilized Humanized Monoclonal Antibody Formulation | E. D. Breen, J. G. Curley, D. E. Overcashier, C. C. Hsu and S. J. Shire |
| 1354-1360 | Carboxyalkylated Histidine Is a pH-Dependent Product of Pegylation with SC-PEG | David C. Wylie, Marcio Voloch, Seoju Lee, Yan-Hui Liu and Susan Cannon-Carlson, et al. |
| 1361-1366 | Pharmaceutical Significance of the Cyclic Imide Form of Recombinant Human Glial Cell Line Derived Neurotrophic Factor | David Markell, John Hui, Linda Narhi, David Lau and Carl LeBel, et al. |
| 1367-1372 | Assessing NSAID Prescription Use as a Predisposing Factor for Gastroesophageal Reflux Disease in a Medicaid Population | Jeffrey Kotzan, William Wade and Hsin Hui Yu |
| 1373-1383 | Workshop on Bioanalytical Methods Validation for Macromolecules: Summary Report | Krys J. Miller, Ronald R. Bowsher, Abbie Celniker, Jacqueline Gibbons and Shalini Gupta, et al. |
| 1384-1388 | Book Reviews |
| 1389-1390 | AAPS Electronic Scientist |
| 1391-1399 | The Development of β-Lactam Antibiotics in Response to the Evolution of β-Lactamases | Sabiha Y. Essack |
| 1400-1404 | MDR1 Genotype-Related Pharmacokinetics of Digoxin After Single Oral Administration in Healthy Japanese Subjects | Toshiyuki Sakaeda, Tsutomu Nakamura, Masanori Horinouchi, Mikio Kakumoto and Nobuko Ohmoto, et al. |
| 1405-1410 | Inhalable Microparticles Containing Drug Combinations to Target Alveolar Macrophages for Treatment of Pulmonary Tuberculosis | Rolee Sharma, Deepali Saxena, Anil K. Dwivedi and Amit Misra |
| 1411-1419 | Biodistribution of Long-Circulating PEG-Grafted Nanocapsules in Mice: Effects of PEG Chain Length and Density | Vanessa Carla Furtado Mosqueira, Philippe Legrand, Jean-Louis Morgat, Michel Vert and Evgueni Mysiakine, et al. |
| 1420-1425 | Transport and Metabolism of the Tea Flavonoid (–)-Epicatechin by the Human Intestinal Cell Line Caco-2 | Jaya Bharathi Vaidyanathan and Thomas Walle |
| 1426-1434 | An Extended Point-Area Deconvolution Approach for Assessing Drug Input Rates | Kuang C. Yeh, Daniel J. Holder, Gregory A. Winchell, Larissa A. Wenning and Thomayant Prueksaritanont |
| 1435-1439 | The Esterase-Like Activity of Serum Albumin May Be Due to Cholinesterase Contamination | Nathalie Chapuis, Corinne Brühlmann, Marianne Reist, Pierre-Alain Carrupt and Joachim M. Mayer, et al. |
| 1440-1447 | Comparison of the Hanson Microette® and the Van Kel Apparatus for In Vitro Release Testing of Topical Semisolid Formulations | Markus Rapedius and James Blanchard |
| 1448-1454 | Phase Transitions of Glycine in Frozen Aqueous Solutions and During Freeze-Drying | Abira Pyne and Raj Suryanarayanan |
| 1455-1460 | Comparison Between Light Induced and Chemically Induced Oxidation of rhVEGF | Eileen T. Duenas, Rodney Keck, Abraham DeVos, Andrew J. S. Jones and Jeffrey L. Cleland |
| 1461-1467 | Oxidation of Recombinant Human Interleukin-2 by Potassium Peroxodisulfate | Jenny A. Cadée, Mies J. van Steenbergen, Cees Versluis, Albert J. R. Heck and Willy J. M. Underberg, et al. |
| 1468-1471 | A Method to Measure the Amount of Drug Penetrated Across the Nail Plate | Ju-Hyun Kim, Chi H. Lee and Hoo-Kyun Choi |
| 1472-1475 | Assessment and Prediction of the Cutaneous Bioavailability of Topical Terbinafine, In Vivo, in Man | Ingo Alberti, Yogeshvar N. Kalia, Aarti Naik and Richard H. Guy |
| 1476-1479 | Cationic Microparticles Are an Effective Delivery System for Immune Stimulatory CpG DNA | Manmohan Singh, Gary Ott, Jina Kazzaz, Mildred Ugozzoli and Maylene Briones, et al. |
| 1480-1484 | Improved DNA/Emulsion Complex Stabilized by poly(ethylene glycol) Conjugated Phospholipid | Sophie Chesnoy, Dominique Durand, Jean Doucet, Donna Beer Stolz and Leaf Huang |
| 1485-1486 | AAPS Electronic Scientist |
| 1481-1482 | Additional Transporter Characterization May Lead to New Pharmaceutical Opportunities | Olafus S. Gudmundsson |
| 1483-1488 | Diamonds in the Rough: Protein Crystals from a Formulation Perspective | Anna Jen and Hans P. Merkle |
| 1489-1496 | Distribution and Diffusion of Sodium Taurocholate and Egg Phosphatidylcholine Aggregates in Rat Intestinal Mucin | Timothy Scott Wiedmann, Heather Herrington, Cinthia Deye and Deborah Kallick |
| 1497-1508 | Predicted Permeability of the Cornea to Topical Drugs | Aurélie Edwards and Mark R. Prausnitz |
| 1509-1513 | Iontophoretic Delivery of Apomorphine In Vitro: Physicochemic Considerations | Gai Ling Li, Meindert Danhof and Joke A. Bouwstra |
| 1514-1520 | Intracellular Drug Delivery Using Low-Frequency Ultrasound: Quantification of Molecular Uptake and Cell Viability | Keyvan Keyhani, Héctor R Guzmán, Aimee Parsons, Thomas N. Lewis and Mark R. Prausnitz |
| 1521-1527 | Gliadin Nanoparticles as Carriers for the Oral Administration of Lipophilic Drugs. Relationships Between Bioadhesion and Pharmacokinetics | Miguel Angel Arangoa, Miguel Angel Campanero, Maria Jesus Renedo, Gilles Ponchel and Juan Manuel Irache |
| 1528-1534 | Distinct Characteristics of Organic Cation Transporters, OCT1 and OCT2, in the Basolateral Membrane of Renal Tubules | Yumiko Urakami, Masahiro Okuda, Satohiro Masuda, Maiko Akazawa and Hideyuki Saito, et al. |
| 1535-1541 | Influence of P-Glycoprotein Modulators on Cardiac Uptake, Metabolism, and Effects of Idarubicin | Wonku Kang and Michael Weiss |
| 1542-1549 | Effect of Probenecid on Fluorescein Transport in the Central Nervous System Using In Vitro and In Vivo Models | Haiying Sun, Donald W. Miller and William F. Elmquist |
| 1550-1555 | The Cellular Uptake and Metabolism of Clodronate in RAW 264 Macrophages | Hannu Mönkkönen, Michael J. Rogers, Niina Makkonen, Sanna Niva and Seppo Auriola, et al. |
| 1556-1561 | Liquid Dose Pulmonary Instillation of Gentamicin PulmoSpheres® Formulations: Tissue Distribution and Pharmacokinetics in Rabbits | Dan J. Smith, Linda M. Gambone, Thomas Tarara, Diana R. Meays and Luis A. Dellamary, et al. |
| 1562-1569 | Microcrystalline Cellulose-Water Interaction—A Novel Approach Using Thermoporosimetry | Pirjo Luukkonen, Thad Maloney, Jukka Rantanen, Hannu Paulapuro and Jouko Yliruusi |
| 1570-1577 | Use of Solid Corrugated Particles to Enhance Powder Aerosol Performance | Nora Y. K. Chew and Hak-Kim Chan |
| 1578-1585 | Stabilizing and Solubilizing Effects of Sulfobutyl Ether β-Cyclodextrin on Prostaglandin E1 Analogue | Kaneto Uekama, Yukako Hieda, Fumitoshi Hirayama, Hidetoshi Arima and Masao Sudoh, et al. |
| 1586-1592 | Controlled Drug Release from Gels Using Surfactant Aggregates. II. Vesicles Formed from Mixtures of Amphiphilic Drugs and Oppositely Charged Surfactants | Mattias Paulsson and Katarina Edsman |
| 1593-1599 | On the Release of Proteins from Degrading Dextran Methacrylate Hydrogels and the Correlation with the Rheologic Properties of the Hydrogels | Tom Meyvis, Stefaan De Smedt, Barbara Stubbe, Wim Hennink and Joseph Demeester |
| 1600-1606 | Preparation and Characterization of a Composite PLGA and Poly(Acryloyl Hydroxyethyl Starch) Microsphere System for Protein Delivery | Byung H. Woo, Ge Jiang, Yeong W. Jo and Patrick P. DeLuca |
| 1607-1612 | Pharmacokinetics and Pharmacodynamics of 7-Nitroindazole, a Selective Nitric Oxide Synthase Inhibitor, in the Rat Hippocampus | Mark A. Bush and Gary M. Pollack |
| 1613-1619 | Influence of Surface-Modifying Surfactants on the Pharmacokinetic Behavior of 14C-Poly (Methylmethacrylate) Nanoparticles in Experimental Tumor Models | Jörg Lode, Iduna Fichtner, Jörg Kreuter, Antje Berndt and Julia Eva Diederichs, et al. |
| 1620-1626 | Lymphatic Absorption Is a Significant Contributor to the Subcutaneous Bioavailability of Insulin in a Sheep Model | Susan A. Charman, Danielle N. McLennan, Glenn A. Edwards and Christopher J. H. Porter |
| 1627-1630 | Effect of Elastic Liquid-State Vesicle on Apomorphine Iontophoresis Transport Through Human Skin In Vitro | Gai Ling Li, Meindert Danhof and Joke A. Bouwstra |
| 1631-1633 | Inhibition of Nuclear Transcription Factor-κB by Specific IκB Kinase Peptide Inhibitor | Navin Swaroop, Fei Chen, Liying Wang, Sujatha Dokka and David Toledo, et al. |
| 1634-1637 | Physical and Chemical Enhancement of Transdermal Delivery of Triptorelin | Sara Nicoli, Silvia Rimondi, Paolo Colombo and Patrizia Santi |
| 1638-1641 | Enhancement of the Intestinal Absorption of Low Molecular Weight Heparin (LMWH) in Rats and Pigs Using Carbopol® 934P | Maya Thanou, J. Coos Verhoef, Marie-Thérèse Nihot, Jos H. M. Verheijden and Hans E. Junginger |
| 1642-1643 | AAPS Electronic Scientist |
| 1645-1650 | Bioavailability and Bioequivalence: An FDA Regulatory Overview | Mei-Ling Chen, Vinod Shah, Rabindra Patnaik, Wallace Adams and Ajaz Hussain, et al. |
| 1651-1654 | β2-Adrenergic Receptor Genotype-Related Changes in cAMP Levels in Peripheral Blood Mononuclear Cells After Multiple-Dose Oral Procaterol | Hiroo Makimoto, Toshiyuki Sakaeda, Kohshi Nishiguchi, Tomoko Kita and Toshiyuki Sakai, et al. |
| 1655-1659 | Telomere Amount and Length Assay | Yuebo Gan, Kory J. Engelke, Christopher A. Brown and Jessie L.-S. Au |
| 1660-1668 | Comparative Studies on in Vitro Methods for Evaluating in Vivo Function of MDR1 P-Glycoprotein | Yasuhisa Adachi, Hiroshi Suzuki and Yuichi Sugiyama |
| 1669-1676 | MCT1-Mediated Transport of L-Lactic Acid at the Inner Blood–Retinal Barrier: A Possible Route for Delivery of Monocarboxylic Acid Drugs to the Retina | Ken-ichi Hosoya, Tetsu Kondo, Masatoshi Tomi, Hitomi Takanaga and Sumio Ohtsuki, et al. |
| 1677-1684 | Facilitation of Pulmonary Insulin Absorption by H-MAP: Pharmacokinetics and Pharmacodynamics in Rats | Sandra Suarez, Lucila Garcia-Contreras, Donald Sarubbi, Elizabeth Flanders and Doris O'Toole, et al. |
| 1685-1693 | Immediate and Short-Term Cellular and Biochemical Responses to Pulmonary Single-Dose Studies of Insulin and H-MAP | Lucila Garcia-Contreras, Donald Sarubbi, Elizabeth Flanders, Doris O'Toole and John Smart, et al. |
| 1694-1700 | Frequency Dependence of Sonophoresis | Ahmet Tezel, Ashley Sens, Joe Tuchscherer and Samir Mitragotri |
| 1701-1708 | Contributions of Electromigration and Electroosmosis to Iontophoretic Drug Delivery | Diego Marro, Yogeshvar N. Kalia, M. Begoña Delgado-Charro and Richard H. Guy |
| 1709-1713 | Optimizing Iontophoretic Drug Delivery: Identification and Distribution of the Charge-Carrying Species | Diego Marro, Yogeshvar N. Kalia, M. Begoña Delgado-Charro and Richard H. Guy |
| 1714-1720 | Iontophoretic Delivery of Ropinirole Hydrochloride: Effect of Current Density and Vehicle Formulation | Asteria Luzardo-Alvarez, M. Begoña Delgado-Charro and José Blanco-Méndez |
| 1721-1728 | Differentiation of Gut and Hepatic First-Pass Effect of Drugs: 1. Studies of Verapamil in Ported Dogs | Yong-Hee Lee, Barbara A. Perry, Hee-Sang Lee, Jeevan R. Kunta and John P. Sutyak, et al. |
| 1729-1734 | Predictive Ability of Level A in Vitro-in Vivo Correlation for RingCap Controlled-Release Acetaminophen Tablets | James T. Dalton, Arthur B. Straughn, David A. Dickason and George P. Grandolfi |
| 1735-1741 | In Vitro Intestinal Permeability of Factor Xa Inhibitors: Influence of Chemical Structure on Passive Transport and Susceptibility to Efflux | Nicolaas G. M. Schipper, Thomas Österberg, Ulla Wrange, Carina Westberg and Anders Sokolowski, et al. |
| 1742-1746 | Enhanced Bioavailability of Calcitonin Formulated with Alkylglycosides Following Nasal and Ocular Administration in Rats | Fakhrul Ahsan, John Arnold, Elias Meezan and Dennis J. Pillion |
| 1747-1753 | Enhancement of Bone Growth by Sustained Delivery of Recombinant Human Bone Morphogenetic Protein-2 in a Polymeric Matrix | Byung Ho Woo, Betsy F. Fink, Richard Page, Jay A. Schrier and Yeong Woo Jo, et al. |
| 1754-1759 | In Situ Study of Insulin Aggregation Induced by Water-Organic Solvent Interface | Young Min Kwon, Miroslav Baudys, Kristine Knutson and Sung Wan Kim |
| 1760-1766 | Predicting Plasticization Efficiency from Three-Dimensional Molecular Structure of a Polymer Plasticizer | Maarit Tarvainen, Riitta Sutinen, Marja Somppi, Petteri Paronen and Antti Poso |
| 1767-1774 | Molecular Mobility and Fragility in Indomethacin: A Thermally Stimulated Depolarization Current Study | Natália T. Correia, Joaquim J. Moura Ramos, Marc Descamps and George Collins |
| 1775-1781 | In Vitro and in Vivo Properties of Recombinant Human Serum Albumin from Pichia Pastoris Purified by a Method of Short Processing Time | Hiroshi Watanabe, Keishi Yamasaki, Ulrich Kragh-Hansen, Sumio Tanase and Kumiko Harada, et al. |
| 1782-1788 | Multilamellar Liposomes and Solid-Supported Lipid Membranes (TRANSIL): Screening of Lipid-Water Partitioning Toward a High-Throughput Scale | Angelika Loidl-Stahlhofen, Thorsten Hartmann, Matthias Schöttner, Cornelia Röhring and Hanna Brodowsky, et al. |
| 1789-1793 | Transdermal Delivery of Antisense Oligonucleotides with Microprojection Patch (macroflux®) Technology | WeiQi Lin, Michel Cormier, Ahmad Samiee, Angie Griffin and Bonny Johnson, et al. |
| 1794-1796 | A Simple Modified Absorption Potential | Tapan Sanghvi, Nina Ni and Samuel H. Yalkowsky |
| 1797-1800 | An Assessment of Reasonable Tortuosity Values | Douglas C. Scott |
| 1801-1807 | Book Reviews |
| 1808-1809 | AAPS Electronic Scientist |
| 1810 | Obituary: Joachim M. Mayer (1949-2001) | Bernard Testa and Robert Gurny |
| 1811-1813 | Reviewers for Pharmaceutical Research November 2000 Through October 2001 |
| 1814-1817 | Author Index to Volume 18 (2001) |
| 1818-1822 | Subject Index to Volume 18 (2001) |
| 1-6 | Validity of in Vitro Tests on Aqueous Spray Pumps as Surrogates for Nasal Deposition | Julie D. Suman, Beth L. Laube, Ta-chun Lin, Guillaume Brouet and Richard Dalby |
| 7-12 | Increase in the Specific Surface Area of Budesonide During Storage Postmicronization | Vidya Joshi, Sarvajna Dwivedi and Gary H. Ward |
| 13-19 | Physicochemical Characterization and Solubility Analysis of Thalidomide and Its N-Alkyl Analogs | Colleen Goosen, Timothy J. Laing, Jeanetta du Plessis, Theunis C. Goosen and Gordon L. Flynn |
| 20-26 | Effects of a Citrate Buffer System on the Solid-State Chemical Stability of Lyophilized Quinapril Preparations | Jinjiang Li, Yushen Guo and George Zografi |
| 27-33 | Comparison of Bidirectional Cephalexin Transport Across MDCK and Caco-2 Cell Monolayers: Interactions with Peptide Transporters | Wendy S. Putnam, Lin Pan, Ken Tsutsui, Lori Takahashi and Leslie Z. Benet |
| 34-41 | Transport Activity of Human MRP3 Expressed in Sf9 Cells: Comparative Studies with Rat MRP3 | Hidetaka Akita, Hiroshi Suzuki, Tomoko Hirohashi, Hajime Takikawa and Yuichi Sugiyama |
| 42-46 | Influence of Hydrodynamics and Particle Size on the Absorption of Felodipine in Labradors | Annette Scholz, Bertil Abrahamsson, Steffen M. Diebold, Edmund Kostewicz and Britta I. Polentarutti, et al. |
| 47-53 | Development and Application of an Isolated Perfused Rat Liver Model to Study the Stimulation and Inhibition of Tumor Necrosis Factor-α Production ex Vivo | Reza Mehvar and Xiaoping Zhang |
| 54-62 | The Antiviral Protein Human Lactoferrin Is Distributed in the Body to Cytomegalovirus (CMV) Infection-Prone Cells and Tissues | Leonie Beljaars, Hester I. Bakker, Barry W. A. van der Strate, Catharina Smit and Adrian M. Duijvestijn, et al. |
| 63-70 | Macroflux® Microprojection Array Patch Technology: A New and Efficient Approach for Intracutaneous Immunization | James A. Matriano, Michel Cormier, Juanita Johnson, Wendy A. Young and Margaret Buttery, et al. |
| 71-78 | Improved Antioxidant Effect of Idebenone-Loaded Polyethyl-2-Cyanoacrylate Nanocapsules Tested on Human Fibroblasts | Maddalena Palumbo, Alessandra Russo, Venera Cardile, Marcella Renis and Donatella Paolino, et al. |
| 79-86 | Arsonoliposomes, a Novel Class of Arsenic-Containing Liposomes: Effect of Palmitoyl-Arsonolipid-Containing Liposomes on the Viability of Cancer and Normal Cells in Culture | Olga Gortzi, Evangelia Papadimitriou, Christos G. Kontoyannis, Sophia G. Antimisiaris and Panayiotis V. Ioannou |
| 87-91 | Modeling the Pharmacokinetics and Pharmacodynamics of a Unique Oral Hypoglycemic Agent Using Neural Networks | Sam H. Haidar, Steven B. Johnson, Michael J. Fossler and Ajaz S. Hussain |
| 92-98 | Application of Resampling Techniques to Estimate Exact Significance Levels for Covariate Selection During Nonlinear Mixed Effects Model Building: Some Inferences | Jogarao V. S. Gobburu and John Lawrence |
| 99-103 | In Silico Prediction of Optimal in Vivo Delivery Properties Using Convolution-Based Model and Clinical Trial Simulation | Roberto Gomeni, Carla D'Angeli and Alan Bye |
| 104-107 | Multiple Receptor Liquid Chromatographic Stationary Phases: The Co-Immobilization of Nicotinic Receptors, γ-Amino-Butyric Acid Receptors, and N-Methyl D-Aspartate Receptors | Ruin Moaddel, Jean-François Cloix, Gözen Ertem and Irving W. Wainer |
| 108-111 | Cyclosporine A Formulation Affects Its Ocular Distribution in Rabbits | Mitsuaki Kuwano, Hajime Ibuki, Nobuo Morikawa, Atsutoshi Ota and Yoichi Kawashima |
| 112-113 | AAPS Electronic Scientist |
| 115-123 | Influence of the Structure of Drug Moieties on the in Vitro Efficacy of HPMA Copolymer–Geldanamycin Derivative Conjugates | Yuji Kasuya, Zheng-Rong Lu, Pavla Kopečková, S. Esmail Tabibi and Jindřich Kopeček |
| 124-131 | HPLC Determination of Binding of Cisplatin to DNA in the Presence of Biological Thiols: Implications of Dominant Platinum-Thiol Binding to Its Anticancer Action | Erika Volckova, Lea P. Dudones and Rathindra N. Bose |
| 132-139 | Size-Dependency of DL-Lactide/Glycolide Copolymer Particulates for Intra-Articular Delivery System on Phagocytosis in Rat Synovium | Eijiro Horisawa, Katsuaki Kubota, Izumi Tuboi, Keiichi Sato and Hiromitsu Yamamoto, et al. |
| 140-146 | Intracellular Processing of Poly(Ethylene Imine)/Ribozyme Complexes Can Be Observed in Living Cells by Using Confocal Laser Scanning Microscopy and Inhibitor Experiments | Thomas Merdan, Klaus Kunath, Dagmar Fischer, Jindrich Kopecek and Thomas Kissel |
| 147-153 | Comparative Inhibitory Effects of Different Compounds on Rat Oatp1 (Slc21a1)- and Oatp2 (Slc21a5)-Mediated Transport | Yoshihisa Shitara, Daisuke Sugiyama, Hiroyuki Kusuhara, Yukio Kato and Takaaki Abe, et al. |
| 154-161 | Proton Gradient-Dependent Transport of Valproic Acid in Human Placental Brush-Border Membrane Vesicles | Hiroaki Nakamura, Fumihiko Ushigome, Noriko Koyabu, Shoji Satoh and Kiyomi Tsukimori, et al. |
| 162-168 | Permeability Profiles of M-Alkoxysubstituted Pyrrolidinoethylesters of Phenylcarbamic Acid Across Caco-2 Monolayers and Human Skin | Lenka Gyürösiová, Leena Laitinen, Johanna Raiman, Jozef Čižmárik and Eva Sedlárová, et al. |
| 169-174 | The Potential of Chitosan in Enhancing Peptide and Protein Absorption Across the TR146 Cell Culture Model—An in Vitro Model of the Buccal Epithelium | Ana Portero, Carmen Remuñán-López and Hanne Mørck Nielsen |
| 175-181 | Peptide Acylation by Poly(α-Hydroxy Esters) | Andrea Lucke, Josef Kiermaier and Achim Göpferich |
| 182-188 | Experimental and Computational Screening Models for Prediction of Aqueous Drug Solubility | Christel A. S. Bergström, Ulf Norinder, Kristina Luthman and Per Artursson |
| 189-194 | Production and Characterization of a Budesonide Nanosuspension for Pulmonary Administration | Claudia Jacobs and Rainer Helmut Müller |
| 195-201 | Thermophysical Properties of Pharmaceutically Compatible Buffers at Sub-Zero Temperatures: Implications for Freeze-Drying | Evgenyi Y. Shalaev, Tiffany D. Johnson-Elton, Liuquan Chang and Michael J. Pikal |
| 202-208 | Effect of Testosterone Suppression on the Pharmacokinetics of a Potent GnRH Receptor Antagonist | Eugenia A. Iatsimirskaia, Margaret L. Gregory, Kenna L. Anderes, Rosemary Castillo and K. Eric Milgram, et al. |
| 209-214 | Ignoring Pharmacokinetics May Lead to Isoboles Misinterpretation: Illustration with the Norfloxacin-Theophylline Convulsant Interaction in Rats | Miren Cadart, Sandrine Marchand, Claudine Pariat, Serge Bouquet and William Couet |
| 215-216 | AAPS Electronic Scientist |
| 217-226 | Chemistry, Manufacturing, and Controls Information in NDAs and ANDAs, Supplements, Annual Reports, and Other Regulatory Filings | Eric Sheinin and Roger Williams |
| 227-228 | Determination of in Vivo Bioequivalence | Andre J. Jackson |
| 229-238 | Targeting Vaccines to Dendritic Cells | Camilla Foged, Anne Sundblad and Lars Hovgaard |
| 239-245 | Fundamental Effects of Particle Morphology on Lung Delivery: Predictions of Stokes' Law and the Particular Relevance to Dry Powder Inhaler Formulation and Development | Timothy M. Crowder, Jacky A. Rosati, Jeffry D. Schroeter, Anthony J. Hickey and Ted B. Martonen |
| 246-249 | Prevention of Autoimmune Insulitis by Delivery of Interleukin-4 Plasmid Using a Soluble and Biodegradable Polymeric Carrier | Minhyung Lee, Jae Joon Koh, Sang-oh Han, Kyung Soo Ko and Sung Wan Kim |
| 250-257 | Pharmaceutical Evaluation of Gas-Filled Microparticles as Gene Delivery System | Stefanie Seemann, Peter Hauff, Marcus Schultze-Mosgau, Cathleen Lehmann and Regina Reszka |
| 258-264 | In Vivo Lung Deposition of Hollow Porous Particles from a Pressurized Metered Dose Inhaler | Peter H. Hirst, Gary R. Pitcairn, Jeff G. Weers, Thomas E. Tarara and Andrew R. Clark, et al. |
| 265-269 | Use of the Post-Insertion Technique to Insert Peptide Ligands into Pre-Formed Stealth Liposomes with Retention of Binding Activity and Cytotoxicity | João N. Moreira, Tatsuhiro Ishida, Rogério Gaspar and Theresa M. Allen |
| 270-277 | Comparison of Dermatopharmacokinetic vs. Clinicial Efficacy Methods for Bioequivalence Assessment of Miconazole Nitrate Vaginal Cream, 2% in Humans | Lynn K. Pershing, Judy L. Corlett and Joel L. Nelson |
| 278-285 | A Biodegradable Injectable Implant Sustains Systemic and Ocular Delivery of an Aldose Reductase Inhibitor and Ameliorates Biochemical Changes in a Galactose-Fed Rat Model for Diabetic Complications | Jithan V. Aukunuru, Gangadhar Sunkara, Surya P. Ayalasomayajula, Jack DeRuiter and Randall C. Clark, et al. |
| 286-291 | Synthesis and Aromatase Inhibitory Activity of Flavanones | Christelle Pouget, Catherine Fagnere, Jean-Philippe Basly, Anne-Elise Besson and Yves Champavier, et al. |
| 292-298 | Determining Dermal Absorption Parameters in Vivo From Tape Strip Data | Micaela B. Reddy, Audra L. Stinchcomb, Richard H. Guy and Annette L. Bunge |
| 299-305 | Sodium Dependence of Nitrofurantoin Active Transport Across Mammary Epithelia and Effects of Dipyridamole, Nucleosides, and Nucleobases | Phillip M. Gerk, Linda Hanson, Margaret C. Neville and Patrick J. McNamara |
| 306-314 | Understanding and Predicting Drug Delivery from Hydrophilic Matrix Tablets Using the “Sequential Layer” Model | J. Siepmann, A. Streubel and N. A. Peppas |
| 315-321 | Prediction of Poly(Ethylene) Glycol-Drug Eutectic Compositions Using an Index Based on the van't Hoff Equation | Devalina Law, Weili Wang, Eric A. Schmitt and Michelle A. Long |
| 322-329 | Adhesion of Powders for Inhalation: An Evaluation of Drug Detachment from Surfaces Following Deposition from Aerosol Streams | Martyn J. Clarke, Joanne Peart, Stefano Cagnani and Peter R. Byron |
| 330-336 | Neotame Anhydrate Polymorphs I: Preparation and Characterization | Zedong Dong, Brian E. Padden, Jonathon S. Salsbury, Eric J. Munson and Steve A. Schroeder, et al. |
| 337-344 | Development of a Remote Electrode System for Monitoring the Water Content of Materials Inside a Glass Vial | Phe Man Suherman, Peter M. Taylor and Geoff Smith |
| 345-349 | Forecasting the Oral Absorption Behavior of Poorly Soluble Weak Bases Using Solubility and Dissolution Studies in Biorelevant Media | Edmund S. Kostewicz, Ulrich Brauns, Robert Becker and Jennifer B. Dressman |
| 350-354 | A New Method to Determine the Distribution of a Fluorophore in Scalp Skin with Focus on Hair Follicles | Ylva Y. Grams and Joke A. Bouwstra |
| 355 | Erratum: In Situ Determination of Partition and Diffusion Coefficients in the Lipid Bilayers of Stratum Corneum | Samir Mitragotri |
| 356-357 | AAPS Electronic Scientist |
| 359-366 | Content Uniformity and Dose Uniformity: Current Approaches, Statistical Analyses, and Presentation of an Alternative Approach, with Special Reference to Oral Inhalation and Nasal Drug Products | Roger L. Williams, Wallace P. Adams, Guirag Poochikian and Walter W. Hauck |
| 367-376 | Characterization of a Synthetic Anionic Vector for Oligonucleotide Delivery Using in Vivo Whole Body Dynamic Imaging | Bertrand Tavitian, Stéphane Marzabal, Valérie Boutet, Bertrand Kühnast and Salvatore Terrazzino, et al. |
| 377-381 | Quantitative Analysis of Correlation Between Number of Nuclear Plasmids and Gene Expression Activity After Transfection with Cationic Liposomes | Rieko Tachibana, Hideyoshi Harashima, Naoko Ide, Sachiko Ukitsu and Yasuko Ohta, et al. |
| 382-390 | Novel Water Insoluble Lipoparticulates for Gene Delivery | Darin Y. Furgeson, Richard N. Cohen, Ram I. Mahato and Sung Wan Kim |
| 391-395 | Intestinal Patches for Oral Drug Delivery | Zancong Shen and Samir Mitragotri |
| 396-402 | Targeted Delivery of Doxorubicin by HPMA Copolymer-Hyaluronan Bioconjugates | Yi Luo, Nicole J. Bernshaw, Zheng-Rong Lu, Jindrich Kopecek and Glenn D. Prestwich |
| 403-410 | Prolonged Anti-Inflammatory Action of DL-Lactide/Glycolide Copolymer Nanospheres Containing Betamethasone Sodium Phosphate for an Intra-Articular Delivery System in Antigen-Induced Arthritic Rabbit | Eijiro Horisawa, Tsuyoshi Hirota, Satoko Kawazoe, Jun Yamada and Hiromitsu Yamamoto, et al. |
| 411-417 | Paclitaxel-Loaded Crosslinked Hyaluronic Acid Films for the Prevention of Postsurgical Adhesions | John K. Jackson, Kevin C. Skinner, Laurette Burgess, Tyler Sun and William L. Hunter, et al. |
| 418-422 | Block Copolymer Micelles for the Encapsulation and Delivery of Amphotericin B | Afsaneh Lavasanifar, John Samuel, Saeed Sattari and Glen S. Kwon |
| 423-426 | Occlusive Properties of Monolayer Patches: In Vitro and in Vivo Evaluation | Antonella Casiraghi, Paola Minghetti, Francesco Cilurzo, Luisa Montanari and Aarti Naik |
| 427-433 | Transepidermal Transport Enhancement of Insulin by Lipid Extraction and Iontophoresis | Sumeet K. Rastogi and Jagdish Singh |
| 434-439 | Percutaneous Delivery of Thalidomide and Its N-Alkyl Analogs | Colleen Goosen, Timothy J. Laing, Jeanetta du Plessis, Theunis C. Goosen and Guang-Wei Lu, et al. |
| 440-444 | Electrically Modulated Transdermal Delivery of Fentanyl | Rajkumar Conjeevaram, Ajay K. Banga and Lei Zhang |
| 445-450 | Insulin Permeability Across an in Vitro Dynamic Model of Endothelium | Francesca Salvetti, Paolo Cecchetti, Damir Janigro, Antonio Lucacchini and Luca Benzi, et al. |
| 451-456 | On the Transport of Lipoplexes Through Cystic Fibrosis Sputum | Niek N. Sanders, Elsa Van Rompaey, Stefaan C. De Smedt and Joseph Demeester |
| 457-462 | Can the Enhanced Renal Clearance of Antibiotics in Cystic Fibrosis Patients Be Explained by P-Glycoprotein Transport? | Miki Susanto and Leslie Z. Benet |
| 463-469 | Gompertz Pharmacokinetic Model for Drug Disposition | Dexter M. Easton |
| 470-476 | Bias in the Wagner–Nelson Estimate of the Fraction of Drug Absorbed | Yibin Wang and Jerry Nedelman |
| 477-483 | A Spectroscopic Investigation of Hydrogen Bond Patterns in Crystalline and Amorphous Phases in Dihydropyridine Calcium Channel Blockers | Xiaolin Charlie Tang, Michael J. Pikal and Lynne S. Taylor |
| 484-490 | The Effect of Temperature on Hydrogen Bonding in Crystalline and Amorphous Phases in Dihydropyrine Calcium Channel Blockers | Xiaolin Charlie Tang, Michael J. Pikal and Lynne S. Taylor |
| 491-496 | Plasticity and Slip System of Plate-Shaped Crystals of L-Lysine Monohydrochloride Dihydrate | Rebanta Bandyopadhyay and David J. W. Grant |
| 497-503 | Estimation of Aqueous Solubility of Organic Compounds with QSPR Approach | Hua Gao, Veerabahu Shanmugasundaram and Pil Lee |
| 504-510 | Interaction Between Lactate Dehydrogenase and Tween 80 in Aqueous Solution | Anna Hillgren, Hans Evertsson and Maggie Aldén |
| 511-516 | Inverse Relationship of Protein Concentration and Aggregation | Michael J. Treuheit, Andrew A. Kosky and David N. Brems |
| 517-521 | Kinetics and Mechanism of Hydrolysis of Efavirenz | Michael B. Maurin, Susan M. Rowe, Karl Blom and Michael E. Pierce |
| 522-529 | Electrochemical and Spectroelectrochemical Behavior of the Main Photodegradation Product of Nifedipine: The Nitrosopyridine Derivative | L. J. Núñez-Vergara, S. Bollo, J. Fuentealba, J. C. Sturm and J. A. Squella |
| 530-537 | High Sensitivity of Zn2+ Insulin to Metal-Catalyzed Oxidation: Detection of 2-Oxo-Histidine by Tandem Mass Spectrometry | Susan W. Hovorka, Homigol Biesiada, Todd D. Williams, Andreas Hühmer and Christian Schöneich |
| 538-545 | Oxidative Degradation of a Sulfonamide-Containing 5,6-Dihydro-4-Hydroxy-2-Pyrone in Aqueous/Organic Cosolvent Mixtures | Susan W. Hovorka, Michael J. Hageman and Christian Schöneich |
| 546-550 | In Vitro Characterization and in Vivo Testosterone Suppression of 6-Month Release Poly(D,L-Lactide) Leuprolide Microspheres | Byung Ho Woo, Kyu-Heum Na, Bhas A. Dani, Ge Jiang and B. C. Thanoo, et al. |
| 551-555 | Simulation of the Pharmacokinetic Profile of Methazolamide in Blood: Effect of Erythrocyte Carbonic Anhydrase Binding on Drug Disposition | Malaz A. AbuTarif and David R. Taft |
| 556-560 | Characterization of Povidone Products by Means of 13C-NMR, MALDI-TOF, and Electrospray Mass Spectrometry | Klaus Raith, Andrea V. Kühn, Fred Rosche, Raik Wolf and Reinhard H. H. Neubert |
| 561-566 | Book Reviews |
| 567-568 | AAPS Electronic Scientist |
| 569-577 | Pharmaceutical Strategies Utilizing Recombinant Human Serum Albumin | Victor Tuan Giam Chuang, Ulrich Kragh-Hansen and Masaki Otagiri |
| 578-587 | Polymers and Gels as Molecular Recognition Agents | Nicholas A. Peppas and Yanbin Huang |
| 588-594 | In Vitro Characterization of Hepatic Flavopiridol Metabolism Using Human Liver Microsomes and Recombinant UGT Enzymes | Jacqueline Ramírez, Lalitha Iyer, Kim Journault, Patrick Bélanger and Federico Innocenti, et al. |
| 595-601 | Transfer of Lipophilic Markers from PLGA and Polystyrene Nanoparticles to Caco-2 Monolayers Mimics Particle Uptake | Peter Pietzonka, Barbara Rothen-Rutishauser, Peter Langguth, Heidi Wunderli-Allenspach and Elke Walter, et al. |
| 602-608 | The Role of Glutathione in the Permeation Enhancing Effect of Thiolated Polymers | Andreas E. Clausen, Constantia E. Kast and Andreas Bernkop-Schnürch |
| 609-614 | Structure-Activity Relationship of Reversibly Lipidized Peptides: Studies of Fatty Acid-Desmopressin Conjugates | Jeff Wang, Daphne Wu and Wei-Chiang Shen |
| 615-620 | In Vivo Kinetic Analysis of Covalent Binding Between N-Acetyl-L-Cysteine and Plasma Protein Through the Formation of Mixed Disulfide in Rats | Daisuke Harada, Shinsaku Naito, Isao Hiraoka and Masaki Otagiri |
| 621-628 | Insulin Aspart (AspB28 Human Insulin) Derivatives Formed in Pharmaceutical Solutions | Mette Uve Jars, Aage Hvass and Dorte Waaben |
| 629-633 | Lysozyme Stability in Primary Emulsion for PLGA Microsphere Preparation: Effect of Recovery Methods and Stabilizing Excipients | Feirong Kang, Ge Jiang, Anne Hinderliter, Patrick P. DeLuca and Jagdish Singh |
| 634-639 | Analysis Methods of Polysorbate 20: A New Method to Assess the Stability of Polysorbate 20 and Established Methods That May Overlook Degraded Polysorbate 20 | Mehrnaz Khossravi, Yung-Hsiang Kao, Randall J. Mrsny and Theresa D. Sweeney |
| 640-648 | Influence of Polymorphism on the Surface Energetics of Salmeterol Xinafoate Crystallized from Supercritical Fluids | Henry H. Y. Tong, Boris Yu. Shekunov, Peter York and Albert H. L. Chow |
| 649-654 | Influence of Alkali Metal Counterions on the Glass Transition Temperature of Amorphous Indomethacin Salts | Ping Tong, Lynne S. Taylor and George Zografi |
| 655-660 | High Throughput Screening of Transdermal Formulations | Pankaj Karande and Samir Mitragotri |
| 661-668 | Transdermal Delivery of Highly Lipophilic Drugs: In Vitro Fluxes of Antiestrogens, Permeation Enhancers, and Solvents from Liquid Formulations | Adrian P. Funke, Roman Schiller, Hans W. Motzkus, Clemens Günther and Rainer H. Müller, et al. |
| 669-675 | Utility of MTT Assay in Three-Dimensional Cultured Human Skin Model as an Alternative for Draize Skin Irritation Test: Approach Using Diffusion Law of Irritant in Skin and Toxicokinetics-Toxicodynamics Correlation | Tetsuya Watanabe, Tetsuya Hasegawa, Hidekazu Takahashi, Takuya Ishibashi and Hiroshi Itagaki, et al. |
| 676-680 | Massive and Selective Delivery of Lipid-Coated Cationic Lipoplexes of Oligonucleotides Targeted in Vivo to Hepatic Endothelial Cells | Martin Bartsch, Alida H. Weeke-Klimp, Dirk K. F. Meijer, Gerrit L. Scherphof and Jan A. A. M. Kamps |
| 681-688 | Self-Assembled Hydrogel Nanoparticles Responsive to Tumor Extracellular pH from Pullulan Derivative/Sulfonamide Conjugate: Characterization, Aggregation, and Adriamycin Release in Vitro | Kun Na and You Han Bae |
| 689-695 | Improved Lung Delivery from a Passive Dry Powder Inhaler Using an Engineered PulmoSphere® Powder | Sarma P. Duddu, Steven A. Sisk, Yulia H. Walter, Thomas E. Tarara and Kevin R. Trimble, et al. |
| 697-704 | Drug Disposition Viewed in Terms of the Fractal Volume of Distribution | Vangelis Karalis and Panos Macheras |
| 705-708 | Transdermal Iontophoresis of Tacrine in Vivo | Tarja Kankkunen, Raimo Sulkava, Marja Vuorio, Kyösti Kontturi and Jouni Hirvonen |
| 709-713 | Blunted Induction of Hepatic CYP4A in TNF (p55-/-/p75-/-) Double Receptor Knockout Mice Following Clofibrate Treatment | Peter J. Van Ess, Samuel Poloyac, Mark P. Mattson and Robert A. Blouin |
| 714-715 | AAPS Electronic Scientist |
| 715-728 | Recent Advances in Vaccine Adjuvants | Manmohan Singh and Derek T. O'Hagan |
| 729-737 | Molecular Factors Influencing Retention on Immobilized Artificial Membranes (IAM) Compared to Partitioning in Liposomes and n-Octanol | Agnes Taillardat-Bertschinger, Catherine A. Marca Martinet, Pierre-Alain Carrupt, Marianne Reist and Giulia Caron, et al. |
| 738-743 | Organic Anion Transporter oatp2-Mediated Interaction between Digoxin and Amiodarone in the Rat Liver | Takaaki Kodawara, Satohiro Masuda, Hiroko Wakasugi, Yuichi Uwai and Takahiro Futami, et al. |
| 744-754 | Conjugates of Antisense Oligonucleotides with the Tat and Antennapedia Cell-Penetrating Peptides: Effects on Cellular Uptake, Binding to Target Sequences, and Biologic Actions | Anna Astriab-Fisher, Dimitri Sergueev, Michael Fisher, Barbara Ramsay Shaw and R. L. Juliano |
| 755-764 | Alginate/Poly-L-Lysine Microparticles for the Intestinal Delivery of Antisense Oligonucleotides | María González Ferreiro, Lloyd G. Tillman, Gregory Hardee and Roland Bodmeier |
| 765-772 | Are MDCK Cells Transfected with the Human MDR1 Gene a Good Model of the Human Intestinal Mucosa? | Fuxing Tang, Kazutoshi Horie and Ronald T. Borchardt |
| 773-779 | Are MDCK Cells Transfected with the Human MRP2 Gene a Good Model of the Human Intestinal Mucosa? | Fuxing Tang, Kazutoshi Horie and Ronald T. Borchardt |
| 780-786 | Characterization of the Efflux Transporter(s) Responsible for Restricting Intestinal Mucosa Permeation of an Acyloxyalkoxy-Based Cyclic Prodrug of the Opioid Peptide DADLE | Fuxing Tang and Ronald T. Borchardt |
| 787-793 | Characterization of the Efflux Transporter(s) Responsible for Restricting Intestinal Mucosa Permeation of the Coumarinic Acid-Based Cyclic Prodrug of the Opioid Peptide DADLE | Fuxing Tang and Ronald T. Borchardt |
| 794-801 | A Modified Coumarinic Acid-Based Cyclic Prodrug of an Opioid Peptide: Its Enzymatic and Chemical Stability and Cell Permeation Characteristics | Hui Ouyang, Fuxing Tang, Teruna J. Siahaan and Ronald T. Borchardt |
| 802-809 | Effects of Grapefruit Juice and Orange Juice on the Intestinal Efflux of P-Glycoprotein Substrates | Run Tian, Noriko Koyabu, Hitomi Takanaga, Hirotami Matsuo and Hisakazu Ohtani, et al. |
| 810-817 | The Structure of PEG-Modified Poly(Ethylene Imines) Influences Biodistribution and Pharmacokinetics of Their Complexes with NF-κB Decoy in Mice | Klaus Kunath, Anke von Harpe, Holger Petersen, Dagmar Fischer and Karlheinz Voigt, et al. |
| 818-824 | Physicochemical Characterization of Hexetidine-Impregnated Endotracheal Tube Poly(vinyl Chloride) and Resistance to Adherence of Respiratory Bacterial Pathogens | David S. Jones, James G. McGovern, A. David Woolfson, Colin G. Adair and Sean P. Gorman |
| 825-831 | Transport and Utilization of Arginine and Arginine-Containing Peptides by Rat Alveolar Macrophages | Xiao-Dong Yang, Jane Y. C. Ma, Mark W. Barger and Joseph K. H. Ma |
| 832-837 | Regional Peptide Uptake Study in the Rat Intestinal Mucosa: Glatiramer Acetate as a Model Drug | Susan Haupt, Efrat Gil, Regin Tirosh, Ety Klinger and Alexander Gad, et al. |
| 838-844 | Tissue Distribution of [14C]Sucrose Octasulfate following Oral Administration to Rats | Linda M. Hiebert, Sandra M. Wice, Tilly Ping, Ronald E. Hileman and Tülay Polat, et al. |
| 845-851 | Preparation and Characterization of Mono-PEGylated Epidermal Growth Factor: Evaluation of in Vitro Biologic Activity | Haeshin Lee and Tae Gwan Park |
| 852-857 | Evaluation of Capacity-Limited First-Pass Effect through Liver by Three-Points Sampling in Portal and Hepatic Veins and Systemic Artery | Shinya Ueda, Kiyoshi Yamaoka, Jyoji Yui, Akio Shigematsu and Terumichi Nakagawa |
| 858-867 | Sex Specificity in Methadone Analgesia in the Rat: A Population Pharmacokinetic and Pharmacodynamic Approach | Monica Rodriguez, M. Angeles Carlos, Ignacio Ortega, Elena Suarez and Rosario Calvo, et al. |
| 868-874 | Comparison of Oral Absorption and Bioavailability of Drugs Between Monkey and Human | Win L. Chiou and Paul W. Buehler |
| 875-880 | A Novel Phase Inversion-Based Process for the Preparation of Lipid Nanocarriers | Béatrice Heurtault, Patrick Saulnier, Brigitte Pech, Jacques-Emile Proust and Jean-Pierre Benoit |
| 881-886 | Investigation of Pharmaceutical Oil/Water Microemulsions by Small-Angle Scattering | Anuj Shukla, Martin Janich, Konstanze Jahn, Annett Krause and Mikael A. Kiselev, et al. |
| 887-893 | New Methods Characterizing Avalanche Behavior to Determine Powder Flow | François Lavoie, Louis Cartilier and Roch Thibert |
| 894-900 | Crystallization Behavior of Mannitol in Frozen Aqueous Solutions | Raghu K. Cavatur, N. Murti Vemuri, Abira Pyne, Zofia Chrzan and David Toledo-Velasquez, et al. |
| 901-908 | Crystallization of Mannitol below Tg′ during Freeze-Drying in Binary and Ternary Aqueous Systems | Abira Pyne, Rahul Surana and Raj Suryanarayanan |
| 909-913 | Simulation for Population Pharmacodynamic Analysis of Dose-Ranging Trials: Usefulness of the Mixture Model Analysis for Detecting Nonresponders | Takeshi Shiiki, Yukiya Hashimoto and Ken-ichi Inui |
| 914-918 | Quantitative Assessment of Chimeraplast Stability in Biological Fluids by Polyacrylamide Gel Electrophoresis and Laser-Assisted Fluorescence Analysis | David de Semir, Anna Avinyó, Sara Larriba, Virginia Nunes and Teresa Casals, et al. |
| 919-920 | AAPS Update |
| 921-925 | Biopharmaceutics Classification System: The Scientific Basis for Biowaiver Extensions | Lawrence X. Yu, Gordon L. Amidon, James E. Polli, Hong Zhao and Mehul U. Mehta, et al. |
| 926-932 | Rational Design of Peptide-Based Tumor Vaccines | Wilson S. Meng and Lisa H. Butterfield |
| 933-938 | Cationic Cholesterol Promotes Gene Transfection Using the Nuclear Localization Signal in Protamine | Ari Noguchi, Naohide Hirashima and Mamoru Nakanishi |
| 939-946 | Genetic Immunization Using Nanoparticles Engineered from Microemulsion Precursors | Zhengrong Cui and Russell J. Mumper |
| 947-953 | Bilayer Films for Mucosal (Genetic) Immunization via the Buccal Route in Rabbits | Zhengrong Cui and Russell J. Mumper |
| 954-959 | Controlled Release of Plasmid DNA from a Genetically Engineered Silk-Elastinlike Hydrogel | Zaki Megeed, Joseph Cappello and Hamidreza Ghandehari |
| 960-967 | The Lower-Generation Polypropylenimine Dendrimers Are Effective Gene-Transfer Agents | Bernd H. Zinselmeyer, Simon P. Mackay, Andreas G. Schatzlein and Ijeoma F. Uchegbu |
| 968-975 | Glucose-Modulated Transgene Expression via Recombinant Adeno-Associated Virus | Ya-Wun Yang, Yuan-Chiao Hsieh and Chih-Kai Chao |
| 976-981 | Prediction of Drug Transport Through the Blood-Brain Barrier in Vivo: A Comparison Between Two in Vitro Cell Models | Stefan Lundquist, Mila Renftel, Julien Brillault, Laurence Fenart and Roméo Cecchelli, et al. |
| 982-990 | Role of Ascorbic Acid in Stratum Corneum Lipid Models Exposed to UV Irradiation | Hagen Trommer, Rolf Böttcher, Andreas Pöppl, Joachim Hoentsch and Siegfried Wartewig, et al. |
| 991-997 | Transdermal Delivery of Pergolide from Surfactant-Based Elastic and Rigid Vesicles: Characterization and in Vitro Transport Studies | P. Loan Honeywell-Nguyen, Peter M. Frederik, Paul H. H. Bomans, Hans E. Junginger and Joke A. Bouwstra |
| 998-1008 | Nasal Delivery of Insulin Using Novel Chitosan Based Formulations: A Comparative Study in Two Animal Models Between Simple Chitosan Formulations and Chitosan Nanoparticles | A. M. Dyer, M. Hinchcliffe, P. Watts, J. Castile and I. Jabbal-Gill, et al. |
| 1009-1012 | Evaluation of the AERx Pulmonary Delivery System for Systemic Delivery of a Poorly Soluble Selective D-1 Agonist, ABT-431 | Franklin W. Okumu, Rai-Yun Lee, James D. Blanchard, Anthony Queirolo and Christine M. Woods, et al. |
| 1013-1018 | Characterization of Mefenamic Acid-Guaiacol Ester: Stability and Transport Across Caco-2 Cell Monolayers | Vimon Tantishaiyakul, Kamonthip Wiwattanawongsa, Sirirat Pinsuwan, Srirat Kasiwong and Narubodee Phadoongsombut, et al. |
| 1019-1026 | Modifying the Bitterness of Selected Oral Pharmaceuticals with Cation and Anion Series of Salts | Russell S. J. Keast and Paul A. S. Breslin |
| 1027-1033 | Influence of Structural Variations in Peptidomimetic 4-Amidinophenylalanine-Derived Thrombin Inhibitors on Plasma Clearance and Biliary Excretion in Rats | Jörg Hauptmann, Torsten Steinmetzer, Helmut Vieweg, Peter Wikström and Jörg Stürzebecher |
| 1034-1037 | The N-Demethylation of the Doxepin Isomers Is Mainly Catalyzed by the Polymorphic CYP2C19 | Sebastian Härtter, Gunnel Tybring, Thomas Friedberg, Harald Weigmann and Christoph Hiemke |
| 1038-1045 | Differential Modulation of P-Glycoprotein Expression and Activity by Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors in Cell Culture | Elke Störmer, Lisa L. von Moltke, Michael D. Perloff and David J. Greenblatt |
| 1046-1051 | A Novel in Vitro Delivery System for Assessing the Biological Integrity of Protein upon Release from PLGA Microspheres | Anne Aubert-Pouëssel, David C. Bibby, Marie-Claire Venier-Julienne, François Hindré and Jean-Pierre Benoît |
| 1052-1060 | Sustained Release Chemotherapeutic Microspheres Provide Superior Efficacy over Systemic Therapy and Local Bolus Infusions | Dwaine F. Emerich, Pamela Snodgrass, Denise Lafreniere, Reginald L. Dean and Heather Salzberg, et al. |
| 1061-1067 | Long-Circulating Poly(Ethylene Glycol)-Modified Gelatin Nanoparticles for Intracellular Delivery | Goldie Kaul and Mansoor Amiji |
| 1068-1070 | Relationship Between Particle Size and Impurity Incorporation During Crystallization of (+)-Pseudoephedrine Hydrochloride, Acetaminophen, and Adipic Acid from Aqueous Solution | Chong-Hui Gu and David J. W. Grant |
| 1071-1072 | AAPS Update |
| 1073-1080 | Book Reviews |
| 1083 | PharmRes—More Than the Impact Factor | Vincent H. L. Lee |
| 1084-1090 | Network Structure of Cellulose Ethers Used in Pharmaceutical Applications During Swelling and at Equilibrium | Saša Baumgartner, Julijana Kristl and Nicholas A. Peppas |
| 1091-1096 | Effect of Nanonization on Absorption of 301029: Ex Vivo and In Vivo Pharmacokinetic Correlations Determined by Liquid Chromatography/Mass Spectrometry | Lee Jia, Hong Wong, Cesario Cerna and Steve D. Weitman |
| 1097-1104 | Insoluble Powder Formulation as an Effective Nasal Drug Delivery System | Fusashi Ishikawa, Mika Murano, Minoru Hiraishi, Toshikazu Yamaguchi and Ikumi Tamai, et al. |
| 1105-1113 | Loading of Tetanus Toxoid to Biodegradable Nanoparticles from Branched Poly(Sulfobutyl-Polyvinyl Alcohol)-g-(Lactide-Co-Glycolide) Nanoparticles by Protein Adsorption: A Mechanistic Study | Tobias Jung, Walter Kamm, Armin Breitenbach, Gerhard Klebe and Thomas Kissel |
| 1114-1122 | The Role of Galactose, Lactose, and Galactose Valency in the Biorecognition of N-(2-Hydroxypropyl)Methacrylamide Copolymers by Human Colon Adenocarcinoma Cells | Ayelet David, Pavla Kopecková, Jindrich Kopecek and Abraham Rubinstein |
| 1123-1129 | Ultrasound-Induced Mild Hyperthermia as a Novel Approach to Increase Drug Uptake in Brain Microvessel Endothelial Cells | Cheong-Weon Cho, Yang Liu, Wesley N. Cobb, Thomas K. Henthorn and Kevin Lillehei, et al. |
| 1130-1136 | Artificial Neural Network Prediction of Aerosol Deposition in Human Lungs | Javed Nazir, David J. Barlow, M. Jayne Lawrence, Christopher J. Richardson and Ian Shrubb |
| 1137-1143 | Synthesis of Pegylated Immunonanoparticles | Jean-Christophe Olivier, Ramon Huertas, Hwa Jeong Lee, Frederic Calon and William M. Pardridge |
| 1144-1149 | Sphingosine-Based Liposome as DNA Vector for Intramuscular Gene Delivery | Karin Baraldo, Nicolas Leforestier, Michel Bureau, Nathalie Mignet and Daniel Scherman |
| 1150-1159 | Theoretical and Experimental Exploration of the Lipophilicity of Zwitterionic Drugs in the 1,2-Dichloroethane/Water System | Géraldine Bouchard, Alessandra Pagliara, Pierre-Alain Carrupt, Bernard Testa and Véronique Gobry, et al. |
| 1160-1169 | An Investigation of the Role of Cavitation in Low-Frequency Ultrasound-Mediated Transdermal Drug Transport | Hua Tang, Chiao Chun Joanne Wang, Daniel Blankschtein and Robert Langer |
| 1170-1179 | Increasing Paracellular Porosity by E-Cadherin Peptides: Discovery of Bulge and Groove Regions in the EC1-Domain of E-Cadherin | Ernawati Sinaga, Seetharama D. S. Jois, Mike Avery, Irwan T. Makagiansar and Usman S. F. Tambunan, et al. |
| 1180-1184 | Pathway of Oral Absorption of Heparin with Sodium N-[8-(2-Hydroxybenzoyl)Amino]Caprylate | Dmitry Malkov, Huai-zhen Wang, Steven Dinh and Isabel Gomez-Orellana |
| 1185-1193 | Comparative Uptake Studies of Bioadhesive and Non-Bioadhesive Nanoparticles in Human Intestinal Cell Lines and Rats: The Effect of Mucus on Particle Adsorption and Transport | Isabel Behrens, Ana Isabel Vila Pena, Maria José Alonso and Thomas Kissel |
| 1194-1202 | Mechanism of Corneal Permeation of L-Valyl Ester of Acyclovir: Targeting the Oligopeptide Transporter on the Rabbit Cornea | Banmeet S. Anand and Ashim K. Mitra |
| 1203-1208 | Solubilization of Drugs by Physiological Mixtures of Bile Salts | Timothy Scott Wiedmann, Wei Liang and Lamya Kamel |
| 1209-1214 | Renal Assimilation of Short Chain Peptides: Visualization of Tubular Peptide Uptake | David A. Groneberg, Frank Döring, Monika Nickolaus, Hannelore Daniel and Axel Fischer |
| 1215-1222 | Stable Supersaturated Aqueous Solutions of Silatecan 7-t-Butyldimethylsilyl-10-Hydroxycamptothecin via Chemical Conversion in the Presence of a Chemically Modified β-Cyclodextrin | Tian-xiang Xiang and Bradley D. Anderson |
| 1223-1231 | Characterization of Asparagine Deamidation and Aspartate Isomerization in Recombinant Human Interleukin-11 | Wei Zhang, Marta J. Czupryn, Philip T. Boyle and John Amari |
| 1232-1235 | Chemical Stabilities and Biological Activities of Thalidomide and Its N-Alkyl Analogs | Colleen Goosen, Timothy J. Laing, Jeanetta du Plessis, Theunis C. Goosen and Tharaknath B. Rao, et al. |
| 1236-1243 | Relative Quantification of mRNA Levels in Jurkat T Cells with RT-Real Time-PCR (RT-rt-PCR): New Possibilities for the Screening of Anti-Inflammatory and Cytotoxic Compounds | Jürg Gertsch, Martin Güttinger, Otto Sticher and Jörg Heilmann |
| 1244-1247 | Interactions of n-Tetraalkylammonium Compounds and Biguanides with a Human Renal Organic Cation Transporter (hOCT2) | Mark J. Dresser, Guangqing Xiao, Maya K. Leabman, Andrew T. Gray and Kathleen M. Giacomini |
| 1248-1249 | AAPS Update |
| 1389-1399 | Camptothecin Delivery Methods | A. Hatefi and B. Amsden |
| 1400-1416 | Comparison of Human Duodenum and Caco-2 Gene Expression Profiles for 12,000 Gene Sequences Tags and Correlation with Permeability of 26 Drugs | Duxin Sun, Hans Lennernas, Lynda S. Welage, Jeffery L. Barnett and Christopher P. Landowski, et al. |
| 1417-1423 | PepT1 mRNA Expression Is Induced by Starvation and Its Level Correlates with Absorptive Transport of Cefadroxil Longitudinally in the Rat Intestine | Kazumasa Naruhashi, Yoshimichi Sai, Ikumi Tamai, Nagao Suzuki and Akira Tsuji |
| 1424-1429 | Polyethylene Glycol-Diacyllipid Micelles Demonstrate Increased Accumulation in Subcutaneous Tumors in Mice | Anatoly N. Lukyanov, Zhonggao Gao, Laureen Mazzola and Vladimir P. Torchilin |
| 1430-1438 | Design and Characterization of Liposomes Containing Long-Chain N-AcylPEs for Brain Delivery: Penetration of Liposomes Incorporating GM1 into the Rat Brain | Margarita Mora, Maria-Luisa Sagristá, Domenico Trombetta, Francesco P. Bonina and Anna De Pasquale, et al. |
| 1439-1445 | Improved Inhalation Behavior of Steroid KSR-592 in Vitro with Jethaler® by Polymorphic Transformation to Needle-Like Crystals (β-Form) | Kazuhiko Ikegami, Yoshiaki Kawashima, Hirofumi Takeuchi, Hiromitsu Yamamoto and Nobuyuki Isshiki, et al. |
| 1446-1457 | Rate-Limited Steps of Human Oral Absorption and QSAR Studies | Yuan H. Zhao, Michael H. Abraham, Joelle Le, Anne Hersey and Chris N. Luscombe, et al. |
| 1458-1464 | How Do Fatty Acids Cause Allosteric Binding of Drugs to Human Serum Albumin? | Victor Tuan Giam Chuang and Masaki Otagiri |
| 1465-1470 | Transdermal Use of Phosphorodiamidate Morpholino Oligomer AVI-4472 Inhibits Cytochrome P450 3A2 Activity in Male Rats | Vikram Arora, Tracy L. Hannah, Patrick L. Iversen and Rhonda M. Brand |
| 1471-1479 | In Vitro Transfection of Plasmid DNA by Amine Derivatives of Gelatin Accompanied with Ultrasound Irradiation | Hossein Hosseinkhani, Teruyoshi Aoyama, Shingo Yamamoto, Osamu Ogawa and Yasuhiko Tabata |
| 1480-1487 | Analysis of Poly(D,L-Lactic-Co-Glycolic Acid) Nanosphere Uptake by Human Dendritic Cells and Macrophages In Vitro | M. E. Christine Lutsiak, Deborah R. Robinson, Conrad Coester, Glen S. Kwon and John Samuel |
| 1488-1494 | Uptake of FITC-Chitosan Nanoparticles by A549 Cells | Min Huang, Zengshuan Ma, Eugene Khor and Lee-Yong Lim |
| 1495-1501 | Characterization of the Transport of Uracil Across Caco-2 and LLC-PK1 Cell Monolayers | Hong Li, Suk-Jae Chung and Chang-Koo Shim |
| 1502-1508 | Folate Receptor-Mediated Liposomal Delivery of a Lipophilic Boron Agent to Tumor Cells in Vitro for Neutron Capture Therapy | Jennifer J. Sudimack, Dianne Adams, Joan Rotaru, Supriya Shukla and Junhua Yan, et al. |
| 1509-1515 | Effect of Organic Isothiocyanates on the P-Glycoprotein- and MRP1-Mediated Transport of Daunomycin and Vinblastine | Elaine Tseng, Amrita Kamath and Marilyn E. Morris |
| 1516-1523 | Novel Gastroretentive Dosage Forms: Evaluation of Gastroretentivity and Its Effect on Riboflavin Absorption in Dogs | Eytan A. Klausner, Eran Lavy, David Stepensky, Michael Friedman and Amnon Hoffman |
| 1524-1531 | Particle Interactions Involved in Aerosol Dispersion of Ternary Interactive Mixtures | Margaret D. Louey and Peter J. Stewart |
| 1532-1536 | Peroral Absorption of Octreotide in Pigs Formulated in Delivery Systems on the Basis of Superporous Hydrogel Polymers | Farid A. Dorkoosh, J. Coos Verhoef, Jos H. M. Verheijden, Morteza Rafiee-Tehrani and Gerrit Borchard, et al. |
| 1537-1543 | Receptor-Mediated Pharmacokinetic/Pharmacodynamic Model of Interferon-β 1a in Humans | Donald E. Mager and William J. Jusko |
| 1544-1548 | A Dispersion Model for Cellular Signal Transduction Cascades | Murali Ramanathan |
| 1549-1553 | Crystal Structure of Neotame Anhydrate Polymorph G | Zedong Dong, Victor G. Young, Agam Sheth, Eric J. Munson and Steve A. Schroeder, et al. |
| 1554-1563 | Measurement and Mapping of pH in Hydrating Pharmaceutical Pellets Using Confocal Laser Scanning Microscopy | Sandra J. Cope, Stephen Hibberd, Joanne Whetstone, Ross J. MacRae and Colin D. Melia |
| 1564-1571 | Supercritical Fluids Crystallization of Budesonide and Flunisolide | Sitaram P. Velaga, Rolf Berger and Johan Carlfors |
| 1572-1576 | Dissolution and Partitioning Behavior of Hydrophobic Ion-Paired Compounds | C. S. Lengsfeld, D. Pitera, M. Manning and T. W. Randolph |
| 1577-1580 | Monitoring the Penetration Enhancer Dimethyl Sulfoxide in Human Stratum Corneum in Vivo by Confocal Raman Spectroscopy | Peter J. Caspers, Adrian C. Williams, Elizabeth A. Carter, Howell G. M. Edwards and Brian W. Barry, et al. |
| 1581-1585 | Significant Genetic Linkage of MDR1 Polymorphisms at Positions 3435 and 2677: Functional Relevance to Pharmacokinetics of Digoxin | Masanori Horinouchi, Toshiyuki Sakaeda, Tsutomu Nakamura, Yoshinori Morita and Takao Tamura, et al. |
| 1586-1587 | AAPS Update |
| 1588-1597 | Book Reviews |
| 1599-1605 | In Vivo Characteristics of Cationic Liposomes as Delivery Vectors for Gene Therapy | Sandrine A. L. Audouy, Lou F. M. H. de Leij, Dick Hoekstra and Grietje Molema |
| 1606-1610 | The Use of in Vitro Metabolic Stability for Rapid Selection of Compounds in Early Discovery Based on Their Expected Hepatic Extraction Ratios | Yau Yi Lau, Gopal Krishna, Nathan P. Yumibe, Diane E. Grotz and Elpida Sapidou, et al. |
| 1611-1621 | Predicting Blood–Brain Barrier Partitioning of Organic Molecules Using Membrane–Interaction QSAR Analysis | Manisha Iyer, Rama Mishra, Yi Han and A. J. Hopfinger |
| 1622-1629 | Quantitative Structure–Permeation Relationships for Solute Transport Across Silicone Membranes | Sandrine Geinoz, Sebastien Rey, Gilles Boss, Annette L. Bunge and Richard H. Guy, et al. |
| 1630-1635 | An Integrated Pharmacodynamic Analysis of Erythropoietin, Reticulocyte, and Hemoglobin Responses in Acute Anemia | P. Veng-Pederson, S. Chapel, P. R. L. Schmidt, N. H. Al-Huniti and R. T. Cook, et al. |
| 1636-1647 | Hydraulic Flow and Vascular Clearance Influences on Intravitreal Drug Delivery | Paul J. Missel |
| 1648-1654 | Kinetic Analysis of Covalent Binding Between N-Acetyl-L-Cysteine and Albumin Through the Formation of Mixed Disulfides in Human and Rat Serum in Vitro | Daisuke Harada, Shinsaku Naito and Masaki Otagiri |
| 1655-1662 | Evidence for Dissolution Rate-Limited Absorption of COL-3, a Matrix Metalloproteinase Inhibitor, Leading to the Irregular Absorption Profile in Rats After Oral Administration | Jing Li, Hung Huynh and Eli Chan |
| 1663-1672 | Hydrogen Bonding with Adsorbent During Storage Governs Drug Dissolution from Solid-Dispersion Granules | Manish K. Gupta, Yin-Chao Tseng, David Goldman and Robin H. Bogner |
| 1673-1679 | Transdermal Drug Delivery by Jet Injectors: Energetics of Jet Formation and Penetration | Joy Schramm and Samir Mitragotri |
| 1680-1688 | Enhanced Permeability of Molecular Weight Markers and Poorly Bioavailable Compounds Across Caco-2 Cell Monolayers Using the Absorption Enhancer, Zonula Occludens Toxin | Donna S. Cox, Sangeeta Raje, Huanling Gao, Noha N. Salama and Natalie D. Eddington |
| 1689-1695 | Enhanced Permeability of the Antimicrobial Agent 2,5-Bis(4-Amidinophenyl)Furan Across Caco-2 Cell Monolayers Via Its Methylamidoxime Prodrug | Lian Zhou, Kiho Lee, Dhiren R. Thakker, David W. Boykin and Richard R. Tidwell, et al. |
| 1696-1703 | Transport of HIV-Protease Inhibitors Across 1α,25di-Hydroxy Vitamin D3-Treated Calu-3 Cell Monolayers: Modulation of P-Glycoprotein Activity | Jignesh Patel, Dhananjay Pal, Veena Vangala, Mohit Gandhi and Ashim K. Mitra |
| 1704-1712 | Transepithelial Transport of Prodrugs of the HIV Protease Inhibitors Saquinavir, Indinavir, and Nelfinavir Across Caco-2 Cell Monolayers | Marielle Rouquayrol, Bérangère Gaucher, Dominique Roche, Jacques Greiner and Pierre Vierling |
| 1713-1719 | Poly(d,l-Lactide-Co-Glycolide) Encapsulated Poly(Vinyl Alcohol) Hydrogel as a Drug Delivery System | Tarun K. Mandal, Levon A. Bostanian, Richard A. Graves and Sharlene R. Chapman |
| 1720-1729 | AlbugraninTM, a Recombinant Human Granulocyte Colony Stimulating Factor (G-CSF) Genetically Fused to Recombinant Human Albumin Induces Prolonged Myelopoietic Effects in Mice and Monkeys | Wendy Halpern, Todd A. Riccobene, Heidi Agostini, Kevin Baker and David Stolow, et al. |
| 1730-1735 | Cellular Handling of a Dexamethasone-Anti-E-Selectin Immunoconjugate by Activated Endothelial Cells: Comparison with Free Dexamethasone | Robbert J. Kok, Maaike Everts, Sigridur A. Ásgeirsdóttir, Dirk K. F. Meijer and Grietje Molema |
| 1736-1744 | A Novel Hepatic-Targeting System for Therapeutic Cytokines That Delivers to the Hepatic Asialoglycoprotein Receptor, but Avoids Receptor-Mediated Endocytosis | Haruya Sato, Yukio Kato, Eiko Hayashi, Tomoyuki Tabata and Manabu Suzuki, et al. |
| 1745-1752 | Determination of Local Tissue Concentrations of Bupivacaine Released from Biodegradable Microspheres and the Effect of Vasoactive Compounds on Bupivacaine Tissue Clearance Studied by Microdialysis Sampling | Sarah McDonald, Alexander A. Faibushevich, Susan Garnick, Kieran Mclaughlin and Craig Lunte |
| 1753-1756 | Complexation of VEGF with Bevacizumab Decreases VEGF Clearance in Rats | Vanessa Hsei, Geralyn G. DeGuzman, Allison Nixon and Jacques Gaudreault |
| 1757-1760 | Augmented Expression of the Tight Junction Protein Occludin in Brain Endothelial Cell Line TR-BBB by Rat Angiopoietin-1 Expressed in Baculovirus-Infected Sf Plus Insect Cells | Hisashi Iizasa, Sun-Hye Bae, Tomoko Asashima, Tomohide Kitano and Noriko Matsunaga, et al. |
| 1761-1768 | Assuring Quality and Performance of Sustained and Controlled Release Parenterals: AAPS Workshop Report, Co-Sponsored by FDA and USP | Diane J. Burgess, Ajaz S. Hussain, Thomas S. Ingallinera and Mei-Ling Chen |
| 1769-1770 | AAPS Update |
| 1771-1772 | News from The National Institute of General Medical Sciences: What IS Training in the Pharmacological Sciences? | Peter C. Preusch |
| 1773-1778 | Application of DNA Microarrays in Pharmacogenomics and Toxicogenomics | Khew-Voon Chin and A.-N. Tony Kong |
| 1779-1787 | β-Adrenergic Receptor Polymorphisms: Cardiovascular Disease Associations and Pharmacogenetics | Julie A. Johnson and Steven G. Terra |
| 1788-1800 | A Ligand-Based Approach to Understanding Selectivity of Nuclear Hormone Receptors PXR, CAR, FXR, LXRα, and LXRβ | Sean Ekins, Leonid Mirny and Erin G. Schuetz |
| 1801-1807 | Locally Delivered Polyclonal Antibodies Potentiate Intravenous Antibiotic Efficacy Against Gram-Negative Infections | Nazir A. Barekzi, Adrian G. Felts, Kornelis A. Poelstra, Jeffrey B. Slunt and David W. Grainger |
| 1808-1814 | Targeting Efficiency of Galactosylated Liposomes to Hepatocytes in Vivo: Effect of Lipid Composition | Aki Murao, Makiya Nishikawa, Chittima Managit, Joseph Wong and Shigeru Kawakami, et al. |
| 1815-1821 | Pharmacokinetics and Preventive Effects of Targeted Catalase Derivatives on Hydrogen Peroxide-Induced Injury in Perfused Rat Liver | Yoshiyuki Yabe, Naoki Kobayashi, Makiya Nishikawa, Kiyoshi Mihara and Fumiyoshi Yamashita, et al. |
| 1822-1826 | p-Aminohippurate Transport at the Apical Membrane in the OK Kidney Epithelial Cell Line | Yasushi Habu, Ikuko Yano, Yukiya Hashimoto, Hideyuki Saito and Ken-ichi Inui |
| 1827-1834 | Multivariate Statistics of Disposition Pharmacokinetic Parameters for Structurally Unrelated Drugs Used in Therapeutics | Vangelis Karalis, Anna Tsantili-Kakoulidou and Panos Macheras |
| 1835-1840 | Impact of Omission or Replacement of Data Below the Limit of Quantification on Parameter Estimates in a Two-Compartment Model | Vincent Duval and Mats O. Karlsson |
| 1841-1846 | A Theoretical Analysis of Low-Frequency Sonophoresis: Dependence of Transdermal Transport Pathways on Frequency and Energy Density | Ahmet Tezel, Ashley Sens and Samir Mitragotri |
| 1847-1853 | Effects of Sucrose and Trehalose on the Preservation of the Native Structure of Spray-Dried Lysozyme | Yong-Hong Liao, Marc B. Brown, Tahir Nazir, Abdul Quader and Gary P. Martin |
| 1854-1861 | Protective Mechanism of Stabilizing Excipients Against Dehydration in the Freeze-Drying of Proteins | Yong-Hong Liao, Marc B. Brown, Abdul Quader and Gary P. Martin |
| 1862-1866 | Independence of the Product of Solubility and Distribution Coefficient of pH | Nina Ni, Tapan Sanghvi and Samuel H. Yalkowsky |
| 1867-1872 | Formation of Fine Drug Particles by Cogrinding with Cyclodextrins. I. The Use of β-Cyclodextrin Anhydrate and Hydrate | Arpansiree Wongmekiat, Yuichi Tozuka, Toshio Oguchi and Keiji Yamamoto |
| 1873-1878 | Enthalpy Relaxation Studies of Celecoxib Amorphous Mixtures | Vasu Kumar Kakumanu and Arvind K. Bansal |
| 1879-1884 | The Activation Energy at Tg and the Fragility Index of Indomethacin, Predicted from the Influence of the Heating Rate on the Temperature Position and on the Intensity of Thermally Stimulated Depolarization Current Peak | Joaquim J. Moura Ramos, Natália T. Correia, Raquel Taveira-Marques and George Collins |
| 1885-1893 | A New Mathematical Model Quantifying Drug Release from Bioerodible Microparticles Using Monte Carlo Simulations | Juergen Siepmann, Nathalie Faisant and Jean-Pierre Benoit |
| 1894-1900 | Dissolution Rate Enhancement by in Situ Micronization of Poorly Water-Soluble Drugs | Norbert Rasenack and Bernd W. Müller |
| 1901-1906 | Buccal Transmucosal Delivery of Calcitonin in Rabbits Using Thin-Film Composites | Zhengrong Cui and Russell J. Mumper |
| 1907-1914 | Human, Rat, and Mouse Metabolism of Resveratrol | Chongwoo Yu, Young Geun Shin, Anita Chow, Yongmei Li and Jerome W. Kosmeder, et al. |
| 1915-1923 | Book Reviews |
| 1924-1925 | AAPS Update |
| 1926-1929 | Author Index to Volume 19 (2002) |
| 1930-1936 | Subject Index to Volume 19 (2002) |
| 1-2 | Editorial: A Systems Approach to Drug Development and to Drug Therapy | Walter Wolf |
| 3-15 | Messenger RNA Expression of Transporter and Ion Channel Genes in Undifferentiated and Differentiated Caco-2 Cells Compared to Human Intestines | Pascale Anderle, Vera Rakhmanova, Katie Woodford, Noa Zerangue and Wolfgang Sadée |
| 16-23 | Novel Ethanol-in-Fluorocarbon Microemulsions for Topical Genetic Immunization | Zhengrong Cui, William Fountain, Michael Clark, Michael Jay and Russell J. Mumper |
| 24-30 | Enhanced Oral Bioavailability of Paclitaxel by Coadministration of the P-Glycoprotein Inhibitor KR30031 | Jong Soo Woo, Chang Hyun Lee, Chang Koo Shim and Sung-Joo Hwang |
| 31-37 | Impact of Mrp2 on the Biliary Excretion and Intestinal Absorption of Furosemide, Probenecid, and Methotrexate Using Eisai Hyperbilirubinemic Rats | Cuiping Chen, Dennis Scott, Elizabeth Hanson, Judy Franco and Edwin Berryman, et al. |
| 38-44 | Kinetic Analysis of P-Glycoprotein-Mediated Transport by Using Normal Human Placental Brush-Border Membrane Vesicles | Fumihiko Ushigome, Noriko Koyabu, Shoji Satoh, Kiyomi Tsukimori and Hitoo Nakano, et al. |
| 45-50 | Enhanced Drug-Induced Apoptosis Associated with P-Glycoprotein Overexpression Is Specific to Antimicrotubule Agents | Dong Li, Seong H. Jang, Jonghan Kim, M. Guillaume Wientjes and Jessie L.-S. Au |
| 51-57 | Influence of Spacer Length on Interaction of Mannosylated Liposomes with Human Phagocytic Cells | Andreas Engel, Swapan Kumar Chatterjee, Ali Al-arifi, Dagmar Riemann and Jürgen Langner, et al. |
| 58-63 | Kinetic Analysis of Saturable Myocardial Uptake of Idarubicin in Rat Heart: Effect of Doxorubicin and Hypothermia | Wonku Kang and Michael Weiss |
| 64-72 | In Vitro Cellular Handling and in Vivo Targeting of E-Selectin-Directed Immunoconjugates and Immunoliposomes Used for Drug Delivery to Inflamed Endothelium | Maaike Everts, Gerben A. Koning, Robbert J. Kok, Sigridur A. Ásgeirsdóttir and Dietmar Vestweber, et al. |
| 73-80 | Structural Studies of EDTA-Induced Fibrillation of Salmon Calcitonin | Stefan Seyferth and Geoffrey Lee |
| 81-88 | Microsomal Cytochrome P450 Levels and Activities of Isolated Rat Livers Perfused with Albumin | Ragini Vuppugalla, Rakhi B. Shah, Anjaneya P. Chimalakonda, Charles W. Fisher and Reza Mehvar |
| 89-95 | Hepatobiliary Transport of a Nonpeptidic Endothelin Antagonist, (+)-(5S,6R, 7R)-2-Butyl-7-[2((2S)-2-Carboxypropyl)-4-Methoxyphenyl]-5-(3,4-Methylenedioxyphenyl) Cyclopentenol[1,2-b]Pyridine-6-Carboxylic Acid: Uptake by Isolated Rat Hepatocytes and Canalicular Membrane Vesicles | Naoko Kobayashi, Takeshi Tani, Akihiro Hisaka, Ken-ichi Hara and Toshio Yasumori |
| 96-102 | Computer Simulation of Convective and Diffusive Transport of Controlled-Release Drugs in the Vitreous Humor | Matthew S. Stay, Jing Xu, Theodore W. Randolph and Victor H. Barocas |
| 103-109 | Pharmacokinetics and Metabolism of Transdermal Oxybutynin: In Vitro and in Vivo Performance of a Novel Delivery System | R. Howard Zobrist, Danyi Quan, Heather M. Thomas, Stephanie Stanworth and Steven W. Sanders |
| 110-116 | Microfabricated Porous Silicon Particles Enhance Paracellular Delivery of Insulin Across Intestinal Caco-2 Cell Monolayers | Amy B. Foraker, Rob J. Walczak, Michael H. Cohen, Tony A. Boiarski and Carl F. Grove, et al. |
| 117-125 | Direct Formation of Nanospheres from Amphiphilic β-Cyclodextrin Inclusion Complexes | Erem Memişoğlu, Amélie Bochot, Meral Özalp, Murat Şen and Dominique Duchêne, et al. |
| 126-129 | Modifications in Lipoprotein Surface Charge Alter Cyclosporine A Association with Low-Density Lipoproteins | Kishor M. Wasan and Olena Sivak |
| 130-134 | Oral-Antigen Delivery via a Water-in-Oil Emulsion System Modulates the Balance of the Th1/Th2 Type Response in Oral Tolerance | Kazuyoshi Masuda, Kazutoshi Horie, Ryuji Suzuki, Takayoshi Yoshikawa and Koichiro Hirano |
| 135-138 | Identification of Phase Separation in Solid Dispersions of Itraconazole and Eudragit® E100 Using Microthermal Analysis | Karel Six, John Murphy, Ilse Weuts, Duncan Q. M. Craig and Geert Verreck, et al. |
| 139-140 | AAPS Update |
| 141-142 | Reviewers for Pharmaceutical Research for the Period of November 1, 2001 and October 31, 2002 |
| 143-148 | Fuzzy Modeling of Skin Permeability Coefficients | Angela K. Pannier, Rhonda M. Brand and David D. Jones |
| 149-152 | Analysis of the Initial Burst of Drug Release Coupled with Polymer Surface Degradation | Joo-Woon Lee, Joseph A. Gardella, Wesley Hicks, Robert Hard and Frank V. Bright |
| 153-160 | Poly-L-Arginine Predominantly Increases the Paracellular Permeability of Hydrophilic Macromolecules Across Rabbit Nasal Epithelium in Vitro | Kazuo Ohtake, Takuya Maeno, Hideo Ueda, Hideshi Natsume and Yasunori Morimoto |
| 161-168 | Isolation and Characterization of Caco-2 Subclones Expressing High Levels of Multidrug Resistance Protein Efflux Transporter | Kazutoshi Horie, Fuxing Tang and Ronald T. Borchardt |
| 169-176 | Modulation of Digoxin Transport Across Caco-2 Cell Monolayers by Citrus Fruit Juices: Lime, Lemon, Grapefruit, and Pummelo | Jianguo Xu, Mei Lin Go and Lee-Yong Lim |
| 177-186 | Physicochemical Properties and Transport of Steroids Across Caco-2 Cells | Fried Faassen, Jan Kelder, Johan Lenders, Rob Onderwater and Herman Vromans |
| 187-197 | N-in-One Permeability Studies of Heterogeneous Sets of Compounds Across Caco-2 Cell Monolayers | Leena Laitinen, Heli Kangas, Ann Marie Kaukonen, Kati Hakala and Tapio Kotiaho, et al. |
| 198-204 | Dextran-Methylprednisolone Succinate as a Prodrug of Methylprednisolone: Local Immunosuppressive Effects in Liver After Systemic Administration to Rats | Anjaneya P. Chimalakonda and Reza Mehvar |
| 205-211 | Anhydride Prodrugs for Nonsteroidal Anti-Inflammatory Drugs | Osnat Shaaya, Amir Magora, Tzviel Sheskin, Neeraj Kumar and Abraham J. Domb |
| 212-220 | Dynamics of Endocytosis and Exocytosis of Poly(D,L-Lactide-co-Glycolide) Nanoparticles in Vascular Smooth Muscle Cells | Jayanth Panyam and Vinod Labhasetwar |
| 221-228 | Phagocytosis and Phagosomal Fate of Surface-Modified Microparticles in Dendritic Cells and Macrophages | Lars Thiele, Hans P. Merkle and Elke Walter |
| 229-236 | Tumor-Cell Targeted Epidermal Growth Factor Liposomes Loaded with Boronated Acridine: Uptake and Processing | Erika Bohl Kullberg, Marika Nestor and Lars Gedda |
| 237-246 | Ligand-Specific Targeting of Microspheres to Phagocytes by Surface Modification with Poly(L-Lysine)-Grafted Poly(Ethylene Glycol) Conjugate | Sofia Faraasen, János Vörös, Gábor Csúcs, Marcus Textor and Hans P. Merkle, et al. |
| 247-251 | The Effect of CTAB Concentration in Cationic PLG Microparticles on DNA Adsorption and in Vivo Performance | Manmohan Singh, Mildred Ugozzoli, Maylene Briones, Jina Kazzaz and Elawati Soenawan, et al. |
| 252-256 | Lung Deposition and Pharmacokinetics of Cyclosporine After Aerosolization in Lung Transplant Patients | Gilbert J. Burckart, Gerald C. Smaldone, Michael A. Eldon, Raman Venkataramanan and James Dauber, et al. |
| 257-263 | Dependence of Skin Permeability on Contact Area | Pankaj Karande and Samir Mitragotri |
| 264-269 | Novel Microemulsion Enhancer Formulation for Simultaneous Transdermal Delivery of Hydrophilic and Hydrophobic Drugs | Philip J. Lee, Robert Langer and V. Prasad Shastri |
| 270-274 | Transdermal Penetration of Vasoconstrictors—Present Understanding and Assessment of the Human Epidermal Flux and Retention of Free Bases and Ion-Pairs | Sheree E. Cross, Melanie J. Thompson and Michael S. Roberts |
| 275-282 | A Novel in-Vitro Technique for Studying Percutaneous Permeation with a Membrane-Coated Fiber and Gas Chromatography/Mass Spectrometry: Part I. Performances of the Technique and Determination of the Permeation Rates and Partition Coefficients of Chemical Mixtures | Xin-Rui Xia, Ronald E. Baynes, Nancy A. Monteiro-Riviere, Ross B. Leidy and Damian Shea, et al. |
| 283-291 | The Effect of Additives on the Crystallization of Cefazolin Sodium During Freeze-Drying | Abira Pyne and Raj Suryanarayanan |
| 292-296 | Relative Reactivity of Dihydropyridine Derivatives to Electrogenerated Superoxide Ion in DMSO Solutions: A Voltammetric Approach | María Eugenia Ortiz, Luis Joaquín Núñez-Vergara and Juan Arturo Squella |
| 297-302 | Sterically Stabilized Phospholipid Mixed Micelles: In Vitro Evaluation as a Novel Carrier for Water-Insoluble Drugs | Aparna Krishnadas, Israel Rubinstein and Hayat Önyüksel |
| 303-307 | Characterization of Methacrylated Inulin Hydrogels Designed for Colon Targeting: In Vitro Release of BSA | Guy Van den Mooter, Lies Vervoort and Renaat Kinget |
| 308-318 | Microcalorimetric Measurement of the Interactions Between Water Vapor and Amorphous Pharmaceutical Solids | David Lechuga-Ballesteros, Aziz Bakri and Danforth P. Miller |
| 319-323 | Sorting of Rat SPNT in Renal Epithelium Is Independent of N-Glycosylation | Lara M. Mangravite and Kathleen M. Giacomini |
| 324-327 | Gene Expression Profiles of ABC Transporters and Cytochrome P450 3A in Caco-2 and Human Colorectal Cancer Cell Lines | Tsutomu Nakamura, Toshiyuki Sakaeda, Nobuko Ohmoto, Yuka Moriya and Chiho Komoto, et al. |
| 328-332 | Development of the Liver- and Lobe-Selective Nonviral Gene Transfer Following the Instillation of Naked Plasmid DNA Using Catheter on the Liver Surface in Mice | Ryu Hirayama, Shigeru Kawakami, Koyo Nishida, Mikiro Nakashima and Hitoshi Sasaki, et al. |
| 333 | Erratum: Optimal Design of a Population Pharmacodynamic Experiment for Ivabradine | S. B. Duffull, F. Mentré and L. Aarons |
| 334 | Erratum: Enhancement of Bone Growth by Sustained Delivery of Recombinant Human Bone Morphogenetic Protein-2 in a Polymeric Matrix | Byung Ho Woo, Betsy F. Fink, Richard Page, Jay A. Schrier and Yeong Woo Jo, et al. |
| 335-336 | AAPS Update |
| 337-344 | Residual Solvent Testing: A Review of Gas-Chromatographic and Alternative Techniques | Clayton B'Hymer |
| 345-350 | Intradermal Injection of Transforming Growth Factor-β1 Gene Enhances Wound Healing in Genetically Diabetic Mice | Sophie Chesnoy, Pui-Yan Lee and Leaf Huang |
| 351-359 | Simultaneous Modulation of Multidrug Resistance and Antiapoptotic Cellular Defense by MDR1 and BCL-2 Targeted Antisense Oligonucleotides Enhances the Anticancer Efficacy of Doxorubicin | Refika I. Pakunlu, Thomas J. Cook and Tamara Minko |
| 360-367 | Binding and Cytotoxicity of HPMA Copolymer Conjugates to Lymphocytes Mediated by Receptor-Binding Epitopes | Aijun Tang, Pavla Kopečková and Jindřich Kopeček |
| 368-372 | Disposition Kinetics of α-Tocopherol in Apolipoprotein B Knockout Mice | Koichi Yokogawa, Yuichiro Shima, Tomoka Hashimoto, Makoto Hiyajyo and Kaori Kadoyama, et al. |
| 373-381 | An Improved Cell Culture Model Based on 2/4/A1 Cell Monolayers for Studies of Intestinal Drug Transport: Characterization of Transport Routes | Staffan Tavelin, Jan Taipalensuu, Finn Hallböök, Kati-Sisko Vellonen and Vanessa Moore, et al. |
| 382-389 | Limits for the Scaled Average Bioequivalence of Highly Variable Drugs and Drug Products | Laszlo Tothfalusi and Laszlo Endrenyi |
| 390-396 | Computation of Log BB Values for Compounds Transported Through Carrier-Mediated Mechanisms Using in Vitro Permeability Data from Brain Microvessel Endothelial Cell (BMEC) Monolayers | Helen H. Usansky and Patrick J. Sinko |
| 397-405 | Prediction of the Oral Absorption of Low-Permeability Drugs Using Small Intestine-Like 2/4/A1 Cell Monolayers | Staffan Tavelin, Jan Taipalensuu, Lauri Söderberg, Rick Morrison and Saeho Chong, et al. |
| 406-408 | The Mean Dissolution Time Depends on the Dose/Solubility Ratio | Eleni Rinaki, Aristides Dokoumetzidis and Panos Macheras |
| 409-416 | Direct Evidence That Polysorbate-80-Coated Poly(Butylcyanoacrylate) Nanoparticles Deliver Drugs to the CNS via Specific Mechanisms Requiring Prior Binding of Drug to the Nanoparticles | Jörg Kreuter, Peter Ramge, Valery Petrov, Stefan Hamm and Svetlana E. Gelperina, et al. |
| 417-422 | Antitumor Activity of Folate Receptor-Targeted Liposomal Doxorubicin in a KB Oral Carcinoma Murine Xenograft Model | Xing Q. Pan, Huaqing Wang and Robert J. Lee |
| 423-428 | Liposome-Mediated Targeting of Enzymes to Cancer Cells for Site-Specific Activation of Prodrugs: Comparison with the Corresponding Antibody-Enzyme Conjugate | María José Fonseca, Joycelyn C. Jagtenberg, Hidde J. Haisma and Gert Storm |
| 429-434 | Effect of Colonic Lactulose Availability on the Timing of Drug Release Onset in Vivo from a Unique Colon-Specific Drug Delivery System (CODES™) | Libo Yang, Shunsuke Watanabe, Jinhe Li, James S. Chu and Masataka Katsuma, et al. |
| 435-441 | Monitoring the in Vivo Delivery of Proteins from Carbomer Hydrogels by X-Ray Fluorescence | Donald S. MacLean-McDavitt, J. David Robertson and Michael Jay |
| 442-447 | In Vitro Evaluation of Nebulization Properties, Antimicrobial Activity, and Regional Airway Surface Liquid Concentration of Liposomal Polymyxin B Sulfate | Tejas R. Desai, Gregory J. Tyrrell, Tina Ng and Warren H. Finlay |
| 448-451 | Disposition and Oral Bioavailability in Rats of an Antiviral and Antitumor Amino Acid Phosphoramidate Prodrug of AZT-Monophosphate | Heng Song, Rachel Johns, George W. Griesgraber, Carston R. Wagner and Cheryl L. Zimmerman |
| 452-459 | Preparation and in Vitro/in Vivo Evaluation of Insulin-Loaded Poly(Acryloyl-Hydroxyethyl Starch)-PLGA Composite Microspheres | Ge Jiang, Wei Qiu and Patrick P. DeLuca |
| 460-464 | Evaluation of the in Vivo Disintegration of Solid Dosage Forms of a Bile Acid Sequestrant in Dogs Using γ-Scintigraphy and Correlation to in Vitro Disintegration | Munir A. Hussain, Rong-Kun Chang, Erik Sandefer, Richard C. Page and George A. Digenis |
| 465-470 | Self-Micellization of Gemfibrozil 1-O-β Acyl Glucuronide in Aqueous Solution | David M. Shackleford, Richard J. Prankerd, Martin J. Scanlon and William N. Charman |
| 471-478 | Thermodynamics of Solutions I: Benzoic Acid and Acetylsalicylic Acid as Models for Drug Substances and the Prediction of Solubility | German L. Perlovich and Annette Bauer-Brandl |
| 479-484 | Characterization of Crystalline Drug Nanoparticles Using Atomic Force Microscopy and Complementary Techniques | Huaiqiu Galen Shi, Leon Farber, James N. Michaels, Allison Dickey and Karen C. Thompson, et al. |
| 485-493 | Enhanced Aqueous Dissolution of a Poorly Water Soluble Drug by Novel Particle Engineering Technology: Spray-Freezing into Liquid with Atmospheric Freeze-Drying | True L. Rogers, Andrew C. Nelsen, Marazban Sarkari, Timothy J. Young and Keith P. Johnston, et al. |
| 494-499 | In-Situ Near-Infrared Spectroscopy Monitoring of the Lyophilization Process | Mikael Brülls, Staffan Folestad, Anders Sparén and Anders Rasmuson |
| 500-507 | Characterization of the Thermal Properties of Powder Particles Using Microthermal Analysis | John. R. Murphy, Christopher S. Andrews and Duncan Q. M. Craig |
| 508-514 | Characterization of Particle-Interactions by Atomic Force Microscopy: Effect of Contact Area | Jennifer C. Hooton, Caroline S. German, Stephanie Allen, Martyn C. Davies and Clive J. Roberts, et al. |
| 515-518 | Hollow Filler–Binders as Excipients for Direct Compaction | Gerad K. Bolhuis, Anko C. Eissens, Thijl P. Adrichem, Johannes A. Wesselingh and Henderik W. Frijlink |
| 519-520 | AAPS Update |
| 521-529 | Book Reviews |
| 531-536 | Scientific Considerations of Pharmaceutical Solid Polymorphism in Abbreviated New Drug Applications | Lawrence X. Yu, M. Scott Furness, Andre Raw, Kathy P. Woodland Outlaw and Nashed E. Nashed, et al. |
| 537-544 | Fluorescent Substrates of Sister-P-Glycoprotein (BSEP) Evaluated as Markers of Active Transport and Inhibition: Evidence for Contingent Unequal Binding Sites | Er-jia Wang, Christopher N. Casciano, Robert P. Clement and William W. Johnson |
| 545-551 | 16HBE14o- Human Bronchial Epithelial Cell Layers Express P-Glycoprotein, Lung Resistance-Related Protein, and Caveolin-1 | Carsten Ehrhardt, Carsten Kneuer, Michael Laue, Ulrich Friedrich Schaefer and Kwang-Jin Kim, et al. |
| 552-556 | MDR1 Genotype-Related Duodenal Absorption Rate of Digoxin in Healthy Japanese Subjects | Yoshinori Morita, Toshiyuki Sakaeda, Masanori Horinouchi, Tsutomu Nakamura and Kohei Kuroda, et al. |
| 557-568 | Induction of Cytochrome P450 2B6 and 3A4 Expression by Phenobarbital and Cyclophosphamide in Cultured Human Liver Slices | Hélène Martin, Jean-Pierre Sarsat, Isabelle de Waziers, Chantal Housset and Pierre Balladur, et al. |
| 569-575 | Mechanistic Studies on Nonviral Gene Delivery to the Intestine Using in Vitro Differentiated Cell Culture Models and an in Vivo Rat Intestinal Loop | Sally-Ann Cryan and Caitriona M. O'Driscoll |
| 576-583 | Vitreous Is a Barrier in Nonviral Gene Transfer by Cationic Lipids and Polymers | Leena Pitkänen, Marika Ruponen, Jenni Nieminen and Arto Urtti |
| 584-590 | Influence of Preparation Conditions on Acyclovir-Loaded Poly-d,l-Lactic Acid Nanospheres and Effect of PEG Coating on Ocular Drug Bioavailability | Claudia Giannavola, Claudio Bucolo, Adriana Maltese, Donatella Paolino and Maria Angela Vandelli, et al. |
| 591-596 | How Well Can a T-Cell Epitope Replace Its Parent Carrier Protein? A Dose-Response Study | James S. Cavenaugh, Hsu-Kun Wang, Cory Hansen, Richard S. Smith and James N. Herron |
| 597-604 | Contribution of Ion-Pair Complexation with Bile Salts to the Transport of Organic Cations Across LLC-PK1 Cell Monolayers | Im-Sook Song, Yong-Hae Han, Suk-Jae Chung and Chang-Koo Shim |
| 605-610 | Development of a Dog Microdialysis Model for Determining Synovial Fluid Pharmacokinetics of Anti-Arthritis Compounds Exemplified by Methotrexate | Mingxin Qian, Wanda West, Jing-Tao Wu, Bing Lu and David D. Christ |
| 611-617 | Evaluation of Inhibitory Activity of Casein on Proteases in Rat Intestine | Seiji Ohtani, Kyoko Shirasu, Ken-ichi Ogawara, Kazutaka Higaki and Toshikiro Kimura |
| 618-623 | Morphine Blood-Brain Barrier Transport Is Influenced by Probenecid Co-Administration | Karin Tunblad, E. Niclas Jonsson and Margareta Hammarlund-Udenaes |
| 624-631 | Cell Handling, Membrane-Binding Properties and Membrane-Penetration Modeling Approaches of Pivampicillin and Phthalimidomethylampicillin, Two Basic Esters of Ampicillin, in Comparison with Chloroquine and Azithromycin | Hugues Chanteux, Isabelle Paternotte, Marie-Paule Mingeot-Leclercq, Robert Brasseur and E. Sonveaux, et al. |
| 632-638 | Noninvasive Characterization of Regional Variation in Drug Transport into Human Stratum Corneum in Vivo | Jui-Chen Tsai, Ching-Yu Lin, Hamm-Ming Sheu, Yu-Li Lo and Ying-Hsuan Huang |
| 639-645 | Topical Delivery of 5-Fluorouracil and 6-Mercaptopurine by Their Alkylcarbonyloxymethyl Prodrugs from Water: Vehicle Effects on Design of Prodrugs | Kenneth B. Sloan, Scott Wasdo, Udo Ezike-Mkparu, Thomas Murray and Donna Nickels, et al. |
| 646-652 | Electroosmotic Pore Transport in Human Skin | Olivia D. Uitto and Henry S. White |
| 653-659 | Pretreatment with a Water-Based Surfactant Formulation Affects Transdermal Iontophoretic Delivery of R-Apomorphine in Vitro | Gai Ling Li, Meindert Danhof, Peter M. Frederik and Joke A. Bouwstra |
| 660-667 | Effective Inhibition of Mannitol Crystallization in Frozen Solutions by Sodium Chloride | Chitra Telang, Lian Yu and Raj Suryanarayanan |
| 668-673 | Stability and Release Performance of a Series of Pegylated Copolymeric Micelles | Wen-Jen Lin, Lee-Wei Juang and Chi-Chang Lin |
| 674-683 | The Stenlying Effect of High Hydrostatic Pressure on Thermally and Hydrolytically Labile Nanosized Carriers | Irène Brigger, Laurence Armand-Lefevre, Pierre Chaminade, Madeleine Besnard and Yohan Rigaldie, et al. |
| 684-692 | Validation of the Chloramine-T Induced Oxidation of Human Serum Albumin as a Model for Oxidative Damage in Vivo | Makoto Anraku, Ulrich Kragh-Hansen, Keiichi Kawai, Toru Maruyama and Yasuomi Yamasaki, et al. |
| 693-700 | Correlation of rFVIII Inactivation with Aggregation in Solution | Wei Wang and Drew N. Kelner |
| 701 | Erratum: A Novel Hepatic-Targeting System for Therapeutic Cytokines That Delivers to the Hepatic Asialoglycoprotein Receptor, But Avoids Receptor-Mediated Endocytosis Pharm. Res. 19:1736-1744 (2002) |
| 702-703 | AAPS Update |
| 705-713 | In Vivo and in Vitro Assessment of Baseline Blood-Brain Barrier Parameters in the Presence of Novel Nanoparticles | Paul R. Lockman, Joanna Koziara, Karen E. Roder, Jennifer Paulson and Thomas J. Abbruscato, et al. |
| 714-719 | Evaluation of Folate Conjugate Uptake and Transport by the Choroid Plexus of Mice | Michael D. Kennedy, Karim N. Jallad, June Lu, Philip S. Low and Dor Ben-Amotz |
| 720-727 | Expression and Functional Involvement of Organic Anion Transporting Polypeptide Subtype 3 (Slc21a7) in Rat Choroid Plexus | Hiroyuki Kusuhara, Zhonggui He, Yoshinori Nagata, Yoshitane Nozaki and Takashi Ito, et al. |
| 728-737 | Correlation of Subcellular Compartmentalization of HPMA Copolymer-Mce6 Conjugates with Chemotherapeutic Activity in Human Ovarian Carcinoma Cells | Monica Tijerina, Pavla Kopečková and Jindŕich Kopeček |
| 738-744 | In Vitro Gene Transfection in Human Glioma Cells Using a Novel and Less Cytotoxic Artificial Lipoprotein Delivery System | Guangliang Pan, Mohannad Shawer, Svein Øie and D. Robert Lu |
| 745-748 | Poor Correlation Between Intestinal and Hepatic Metabolic Rates of CYP3A4 Substrates in Rats | Tetsuya Aiba, Yutaka Takehara, Marie Okuno and Yukiya Hashimoto |
| 749-756 | Human Jejunal Permeability of Cyclosporin A: Influence of Surfactants on P-Glycoprotein Efflux in Caco-2 Cells | Yu-Yuan Chiu, Kazutaka Higaki, Brien L. Neudeck, Jeffrey L. Barnett and Lynda S. Welage, et al. |
| 757-764 | Midazolam Exhibits Characteristics of a Highly Permeable P-Glycoprotein Substrate | Sanna Tolle-Sander, Jarkko Rautio, Steve Wring, Joseph W. Polli and James E. Polli |
| 765-771 | Differential Effect of Acute Hepatic Failure on in Vivo and in Vitro P-Glycoprotein Functions in the Intestine | Ryoko Yumoto, Teruo Murakami and Mikihisa Takano |
| 772-778 | Lipophilicities of Baclofen Ester Prodrugs Correlate with Affinities to the ATP-Dependent Efflux Pump P-Glycoprotein: Relevance for Their Permeation Across the Blood-Brain Barrier? | Christiane Leisen, Peter Langguth, Bernd Herbert, Cornelia Dressler and Annette Koggel, et al. |
| 779-787 | Pathways and Kinetics of Deslorelin Degradation in an Airway Epithelial Cell Line (Calu-1) | Kavitha Koushik, Gangadhar Sunkara, Peter Gwilt and Uday B. Kompella |
| 788-796 | Large Porous Particle Impingement on Lung Epithelial Cell Monolayers—Toward Improved Particle Characterization in the Lung | Jennifer Fiegel, Carsten Ehrhardt, Ulrich Friedrich Schaefer, Claus-Michael Lehr and Justin Hanes |
| 797-801 | Dissolution Behavior of a Poorly Water Soluble Compound in the Presence of Tween 80 | Linna R. Chen, James A. Wesley, Shobha Bhattachar, Bienvenido Ruiz and Korey Bahash, et al. |
| 802-803 | Crystalline to Amorphous Transition of Disodium Hydrogen Phosphate During Primary Drying | Abira Pyne, Koustuv Chatterjee and Raj Suryanarayanan |
| 804-809 | Effect of Geometric Structure of Flow Promoting Agents on the Flow Properties of Pharmaceutical Powder Mixture | Kotoe Machida Ohta, Masayoshi Fuji and Masatoshi Chikazawa |
| 810-817 | Preparation and Characterization of Nanofibers Containing Amorphous Drug Dispersions Generated by Electrostatic Spinning | Geert Verreck, Iksoo Chun, Jef Peeters, Joel Rosenblatt and Marcus E. Brewster |
| 818-825 | N-Terminal Site-Specific Mono-PEGylation of Epidermal Growth Factor | Haeshin Lee, Il Ho Jang, Sung Ho Ryu and Tae Gwan Park |
| 826-832 | Targeting Doxorubicin to Epidermal Growth Factor Receptors by Site-Specific Conjugation of C225 to Poly(L-Glutamic Acid) Through a Polyethylene Glycol Spacer | Javier Vega, Shi Ke, Zhen Fan, Sidney Wallace and Chusilp Charsangavej, et al. |
| 833-839 | Wheat Germ Agglutinin Binds to the Epidermal Growth Factor Receptor of Artificial Caco-2 Membranes as Detected by Silver Nanoparticle Enhanced Fluorescence | Nina Lochner, Fritz Pittner, Michael Wirth and Franz Gabor |
| 840-841 | AAPS Update |
| 843-847 | A Rational Approach to Personalized Anticancer Therapy: Chemoinformatic Analysis Reveals Mechanistic Gene-Drug Associations | Kerby Shedden, Leroy B. Townsend, John C. Drach and Gustavo R. Rosania |
| 848-856 | Absorption Rate Limit Considerations for Oral Phosphate Prodrugs | Tycho Heimbach, Doo-Man Oh, Lilian Y. Li, Markus Forsberg and Jouko Savolainen, et al. |
| 857-863 | Prediction of in Vivo Tissue Distribution from in Vitro Data. 2. Influence of Albumin Diffusion from Tissue Pieces During an in Vitro Incubation on Estimated Tissue-to-Unbound Plasma Partition Coefficients (Kpu) | Peter Ballard, Philip A. Arundel, David E. Leahy and Malcolm Rowland |
| 864-872 | Prediction of in Vivo Tissue Distribution from in Vitro Data. 2. Correlation Between in Vitro and in Vivo Tissue Distribution of a Homologous Series of Nine 5-n-Alkyl-5-Ethyl Barbituric Acids | Peter Ballard, David E. Leahy and Malcolm Rowland |
| 873-878 | Prediction of Glass Transition Temperature of Freeze-Dried Formulations by Molecular Dynamics Simulation | Sumie Yoshioka, Yukio Aso and Shigeo Kojima |
| 879-883 | Nuclear Transport by Laser-Induced Pressure Transients | Tai-Yuan David Lin, Daniel J. McAuliffe, Norm Michaud, Hong Zhang and Shun Lee, et al. |
| 884-888 | Controlled Gene Delivery System Based on Thermosensitive Biodegradable Hydrogel | Zhenhua Li, Wen Ning, Jumei Wang, Augustine Choi and Pui-Yan Lee, et al. |
| 889-896 | Targeted Proapoptotic LHRH-BH3 Peptide | Sonia S. Dharap and Tamara Minko |
| 897-899 | Gabapentin Blocks L-Type and P/Q-Type Ca2+ Channels Involved in Depolarization-Stimulated Nitric Oxide Synthase Activity in Primary Cultures of Neurons from Mouse Cerebral Cortex | Michiko Oka, Yoshinori Itoh, Miyuki Wada, Akira Yamamoto and Takuya Fujita |
| 900-903 | P-Glycoprotein Attenuating Effect of Human Intestinal Fluid | Sven Deferme, Jan Tack, Frank Lammert and Patrick Augustijns |
| 904-909 | Apparent Lack of Mrp1-Mediated Efflux at the Luminal Side of Mouse Blood-Brain Barrier Endothelial Cells | Salvatore Cisternino, Christophe Rousselle, Aurelio Lorico, Germana Rappa and Jean-Michel Scherrmann |
| 910-917 | Effect of P-Glycoprotein Modulator, Cyclosporin A, on the Gastrointestinal Excretion of Irinotecan and Its Metabolite SN-38 in Rats | Kazuhiko Arimori, Noriaki Kuroki, Muneaki Hidaka, Tomomi Iwakiri and Keishi Yamasaki, et al. |
| 918-925 | Chemical Stability of Esters of Nicotinic Acid Intended for Pulmonary Administration by Liquid Ventilation | Cheng-Hsuan Hsu, Michael Jay, Paul M. Bummer and Hans-Joachim Lehmler |
| 926-930 | Adsorption and Entrapment of Salicylamide Molecules into the Mesoporous Structure of Folded Sheets Mesoporous Material (FSM-16) | Yuichi Tozuka, Toshio Oguchi and Keiji Yamamoto |
| 931-936 | Development and in Vivo Evaluation of an Oral Delivery System for Low Molecular Weight Heparin Based on Thiolated Polycarbophil | Constantia E. Kast, Davide Guggi, Nina Langoth and Andreas Bernkop-Schnürch |
| 937-942 | Effect of Experimental Renal Failure and Hypotonic Hyponatremia on the Pharmacodynamics of Cefazolin-Induced Seizures in Rats | Masashi Nagata, Takuya Fujichika and Masato Yasuhara |
| 943-953 | Book Reviews |
| 954-955 | AAPS Update |
| 957-961 | Synergy Between 3′Azido-3′deoxythymidine and Paclitaxel in Human Pharynx FaDu Cells | Jeffrey S. Johnston, Andrew Johnson, Yuebo Gan, M. Guillaume Wientjes and Jessie L.-S. Au |
| 962-968 | Physicochemical Properties of Liposomes Affecting Apoptosis Induced by Cationic Liposomes in Macrophages | Shuhei Takano, Yukihiko Aramaki and Seishi Tsuchiya |
| 969-977 | Optimization of an Alum-Adsorbed Vaccine Powder Formulation for Epidermal Powder Immunization | Yuh-Fun Maa, Cassandra Shu, Mahmoud Ameri, Cindy Zuleger and Jenny Che, et al. |
| 978-987 | Imparting Bone Affinity to Glycoproteins Through the Conjugation of Bisphosphonates | Sébastien A. Gittens, John R. Matyas, Ronald F. Zernicke and Hasan Uludağ |
| 988-995 | A Reappraisal of Drug Release Laws Using Monte Carlo Simulations: The Prevalence of the Weibull Function | Kosmas Kosmidis, Panos Argyrakis and Panos Macheras |
| 996-1000 | A Stochastic Model for Optimizing Composite Predictors Based on Gene Expression Profiles | Murali Ramanathan |
| 1001-1008 | Attenuation of Kupffer Cell Activation in Cold-Preserved Livers After Pretreatment of Rats with Methylprednisolone or Its Macromolecular Prodrug | Anjaneya P. Chimalakonda and Reza Mehvar |
| 1009-1014 | Cyclosporine Binds to the Neutral Lipid and Potentially Other Binding Sites of Lipid Transfer Protein I | Mona Kwong and Kishor M. Wasan |
| 1015-1021 | Modulation of Nonspecific Binding in Ultrafiltration Protein Binding Studies | Kyoung-Jin Lee, Rachel Mower, Tom Hollenbeck, Jesus Castelo and Nikole Johnson, et al. |
| 1022-1030 | Hydrotropic Solubilization of Paclitaxel: Analysis of Chemical Structures for Hydrotropic Property | Jaehwi Lee, Sang Cheon Lee, Ghanashyam Acharya, Ching-jer Chang and Kinam Park |
| 1031-1038 | A Mechanistic and Kinetic Study of the E-Ring Hydrolysis and Lactonization of a Novel Phosphoryloxymethyl Prodrug of Camptothecin | Bradley A. Hanson, Richard L. Schowen and Valentino J. Stella |
| 1039-1046 | Effect of Polymer Content and Molecular Weight on the Morphology and Heat- and Moisture-Induced Transformations of Spray-Dried Composite Particles of Amorphous Lactose and Poly(vinylpyrrolidone) | Jonas Berggren and Göran Alderborn |
| 1047-1054 | Characterization of Solid Dispersions of Itraconazole and Hydroxypropylmethylcellulose Prepared by Melt Extrusion, Part II | Karel Six, Hugo Berghmans, Christian Leuner, Jennifer Dressman and Kristof Van Werde, et al. |
| 1055-1062 | PLG Microsphere Size Controls Drug Release Rate Through Several Competing Factors | Cory Berkland, Kyekyoon (Kevin) Kim and Daniel W. Pack |
| 1063-1070 | Polyester-Poly(Ethylene Glycol) Nanoparticles Loaded with the Pure Antiestrogen RU 58668: Physicochemical and Opsonization Properties | Thibault Ameller, Véronique Marsaud, Philippe Legrand, Ruxandra Gref and Gillian Barratt, et al. |
| 1071-1084 | Visualization of Insulin-Loaded Nanocapsules: In Vitro and in Vivo Studies After Oral Administration to Rats | Huguette Pinto-Alphandary, Malam Aboubakar, Danielle Jaillard, Patrick Couvreur and Christine Vauthier |
| 1085-1092 | The Effects of Pluronic® Block Copolymers and Cremophor® EL on Intestinal Lipoprotein Processing and the Potential Link with P-Glycoprotein in Caco-2 Cells | Fergal Seeballuck, Marianne B. Ashford and Caitriona M. O'Driscoll |
| 1093-1100 | Improving Relative Bioavailability of Dicumarol by Reducing Particle Size and Adding the Adhesive Poly(Fumaric-Co-Sebacic) Anhydride | C. G. Thanos, Z. Liu, J. Reineke, E. Edwards and E. Mathiowitz |
| 1101-1102 | AAPS Update |
| 1103-1112 | Polymeric Growth Factor Delivery Strategies for Tissue Engineering | Ruth R. Chen and David J. Mooney |
| 1113-1118 | Xenobiotic Bioconversion in Human Epidermis Models | Audra L. Stinchcomb |
| 1119-1124 | Influence of Drugs and Nutrients on Transporter Gene Expression Levels in Caco-2 and LS180 Intestinal Epithelial Cell Lines | Qing Li, Yoshimichi Sai, Yukio Kato, Ikumi Tamai and Akira Tsuji |
| 1125-1132 | In Vitro Polarized Transport of L-Phenylalanine in Human Nasal Epithelium and Partial Characterization of the Amino Acid Transporters Involved | Remigius Agu, Hoang Vu Dang, Mark Jorissen, Tom Willems and Sandy Vandoninck, et al. |
| 1133-1140 | L-Carnitine Transport in Kidney of Normotensive, Wistar–Kyoto Rats: Effect of Chronic L-Carnitine Administration | Lucía Gómez-Amores, Alfonso Mate and Carmen M. Vázquez |
| 1141-1148 | pH-Dependent Bidirectional Transport of Weakly Basic Drugs Across Caco-2 Monolayers: Implications for Drug–Drug Interactions | Sibylle Neuhoff, Anna-Lena Ungell, Ismael Zamora and Per Artursson |
| 1149-1155 | Predicting Oral Absorption of Drugs: A Case Study with a Novel Class of Antimicrobial Agents | Allen R. Hilgers, Donald P. Smith, John J. Biermacher, Jeffrey S. Day and Jana L. Jensen, et al. |
| 1156-1162 | Pharmacokinetic Model to Describe the Lymphatic Absorption of r-metHu-Leptin After Subcutaneous Injection to Sheep | Danielle N. McLennan, Christopher J. H. Porter, Glenn A. Edwards, Maria Brumm and Steven W. Martin, et al. |
| 1163-1169 | Quantitative Evaluation of the Function of Small Intestinal P-Glycoprotein: Comparative Studies Between in Situ and in Vitro | Yasuhisa Adachi, Hiroshi Suzuki and Yuichi Sugiyama |
| 1170-1176 | Compound Profiling for P-Glycoprotein at the Blood–Brain Barrier Using a Microplate Screening System | Björn Bauer, David S. Miller and Gert Fricker |
| 1177-1183 | Rapid Assessment of P-Glycoprotein Inhibition and Induction in Vitro | Michael D. Perloff, Elke Störmer, Lisa L. von Moltke and David J. Greenblatt |
| 1184-1191 | Effect of the Flavonoids Biochanin A and Silymarin on the P-Glycoprotein-Mediated Transport of Digoxin and Vinblastine in Human Intestinal Caco-2 Cells | Shuzhong Zhang and Marilyn E. Morris |
| 1192-1199 | Rhodamine 123 Requires Carrier-Mediated Influx for Its Activity as a P-Glycoprotein Substrate in Caco-2 Cells | Matthew D. Troutman and Dhiren R. Thakker |
| 1200-1209 | Efflux Ratio Cannot Assess P-Glycoprotein-Mediated Attenuation of Absorptive Transport: Asymmetric Effect of P-Glycoprotein on Absorptive and Secretory Transport Across Caco-2 Cell Monolayers | Matthew D. Troutman and Dhiren R. Thakker |
| 1210-1224 | Novel Experimental Parameters to Quantify the Modulation of Absorptive and Secretory Transport of Compounds by P-Glycoprotein in Cell Culture Models of Intestinal Epithelium | Matthew D. Troutman and Dhiren R. Thakker |
| 1225-1230 | P-Glycoprotein Attenuates Brain Uptake of Substrates After Nasal Instillation | Candace L. Graff and Gary M. Pollack |
| 1231-1238 | Transcytosis of GCSF-Transferrin Across Rat Alveolar Epithelial Cell Monolayers | Adam Widera, Kwang-Jin J. Kim, Edward D. Crandall and Wei-Chiang Shen |
| 1239-1248 | Targeting and Blocking B7 Costimulatory Molecules on Antigen-Presenting Cells Using CTLA4Ig-Conjugated Liposomes: In Vitro Characterization and in Vivo Factors Affecting Biodistribution | Chung-Gyu Park, Natalie W. Thiex, Kyung-Mi Lee, Gregory L. Szot and Jeffery A. Bluestone, et al. |
| 1249-1257 | Interaction of Differently Designed Immunoliposomes with Colon Cancer Cells and Kupffer Cells. An in Vitro Comparison | Gerben A. Koning, Henriëtte W. M. Morselt, Arko Gorter, Theresa M. Allen and Samuel Zalipsky, et al. |
| 1258-1266 | Toward Targeted Oral Vaccine Delivery Systems: Selection of Lectin Mimetics from Combinatorial Libraries | Imelda Lambkin, Clemencia Pinilla, Christa Hamashin, Lisa Spindler and Shannon Russell, et al. |
| 1267-1273 | Effects of Sucrose Oleate and Sucrose Laureate on in Vivo Human Stratum Corneum Permeability | Hilda A. Ayala-Bravo, David Quintanar-Guerrero, Aarti Naik, Yogeshvar N. Kalia and José M. Cornejo-Bravo, et al. |
| 1274-1283 | Physicochemical Investigations on Solid Lipid Nanoparticles and on Oil-Loaded Solid Lipid Nanoparticles: A Nuclear Magnetic Resonance and Electron Spin Resonance Study | Katja Jores, Wolfgang Mehnert and Karsten Mäder |
| 1284-1292 | Novel Polyester-Polysaccharide Nanoparticles | Caroline Lemarchand, Patrick Couvreur, Madeleine Besnard, Dominique Costantini and Ruxandra Gref |
| 1293-1301 | Pharmacokinetic-Pharmacodynamic Relationships of (2S,3S)-Valnoctamide and Its Stereoisomer (2R,3S)-Valnoctamide in Rodent Models of Epilepsy | Nina Isoherranen, H. Steve White, Brian D. Klein, Michael Roeder and José H. Woodhead, et al. |
| 1302-1308 | A High-Throughput Combinatorial Approach for the Discovery of a Cremophor EL-Free Paclitaxel Formulation | Hongming Chen, Zhong Zhang, Chris McNulty, Cameron Olbert and Hye Jeong Yoon, et al. |
| 1309-1316 | Sialic Acid 9-O-Acetylesterase Catalyzes the Hydrolyzing Reaction from Alacepril to Deacetylalacepril | Shigeyuki Usui, Masafumi Kubota, Kazuhiro Iguchi, Tadashi Kiho and Tadashi Sugiyama, et al. |
| 1317-1322 | Water-Oil Partition Profiling of Ionized Drug Molecules Using Cyclic Voltammetry and a 96-Well Microfilter Plate System | Sorina M. Ulmeanu, Henrik Jensen, Géraldine Bouchard, Pierre-Alain Carrupt and Hubert H. Girault |
| 1323-1324 | AAPS Update |
| 1325-1336 | Physical Stability of Proteins in Aqueous Solution: Mechanism and Driving Forces in Nonnative Protein Aggregation | Eva Y. Chi, Sampathkumar Krishnan, Theodore W. Randolph and John F. Carpenter |
| 1337-1350 | Drug Delivery and Transport to Solid Tumors | Seong Hoon Jang, M. Guillaume Wientjes, Dan Lu and Jessie L.-S. Au |
| 1351-1356 | Involvement of Nrf2 and JNK1 in the Activation of Antioxidant Responsive Element (ARE) by Chemopreventive Agent Phenethyl Isothiocyanate (PEITC) | Young-Sam Keum, Edward D. Owuor, Bok-Ryang Kim, Rong Hu and A.-N. Tony Kong |
| 1357-1363 | Evaluation of an Immortalized Retinal Endothelial Cell Line as an In Vitro Model for Drug Transport Studies Across the Blood-Retinal Barrier | Jie Shen, Stacy T. Cross, Diane D. S. Tang-Liu and Devin F. Welty |
| 1364-1372 | Preliminary Investigation into the Expression of Proton-Coupled Oligopeptide Transporters in Neural Retina and Retinal Pigment Epithelium (RPE): Lack of Functional Activity in RPE Plasma Membranes | Scott M. Ocheltree, Richard F. Keep, Hong Shen, Dongli Yang and Bret A. Hughes, et al. |
| 1373-1380 | Assessment of Temporal Biochemical and Gene Transcription Changes in Rat Liver Cytochrome P450: Utility of Real-Time Quantitative RT-PCR | Federico M. Goodsaid, Jairam R. Palamanda, Diana Montgomery, George Mandakas and Chunyan Gu, et al. |
| 1381-1388 | Amino Acid Ester Prodrugs of Floxuridine: Synthesis and Effects of Structure, Stereochemistry, and Site of Esterification on the Rate of Hydrolysis | Balvinder S. Vig, Philip J. Lorenzi, Sachin Mittal, Christopher P. Landowski and Ho-Chul Shin, et al. |
| 1389-1393 | Inhibitory Effect of Zinc on PEPT1-Mediated Transport of Glycylsarcosine and β-Lactam Antibiotics in Human Intestinal Cell Line Caco-2 | Miyako Okamura, Tomohiro Terada, Toshiya Katsura, Hideyuki Saito and Ken-ichi Inui |
| 1394-1400 | Involvement of Multidrug Resistance Associated Protein 1 (Mrp1) in the Efflux Transport of 17β Estradiol-D-17β-Glucuronide (E217βG) Across the Blood-Brain Barrier | Daisuke Sugiyama, Hiroyuki Kusuhara, Yong-Joo Lee and Yuichi Sugiyama |
| 1401-1408 | QSAR Analysis of the Inhibition of Recombinant CYP 3A4 Activity by Structurally Diverse Compounds Using a Genetic Algorithm-Combined Partial Least Squares Method | Suchada Wanchana, Fumiyoshi Yamashita and Mitsuru Hashida |
| 1409-1416 | Ocular Pharmacokinetic Modeling Using Corneal Absorption and Desorption Rates from in Vitro Permeation Experiments with Cultured Corneal Epithelial Cells | Veli-Pekka Ranta, Mirka Laavola, Elisa Toropainen, Kati-Sisko Vellonen and Anu Talvitie, et al. |
| 1417-1422 | The Effect of Low Concentrations of Molecularly Dispersed Poly(Vinylpyrrolidone) on Indomethacin Crystallization from the Amorphous State | Kieran J. Crowley and George Zografi |
| 1423-1429 | Thermal Analysis of Trace Levels of Polymorphic Impurity in Salmeterol Xinafoate Samples | Henry H. Y. Tong, Boris Yu. Shekunov, Peter York and Albert H. L. Chow |
| 1430-1436 | Direct Observation of the Enthalpy Relaxation and the Recovery Processes of Maltose-Based Amorphous Formulation by Isothermal Microcalorimetry | Kohsaku Kawakami and Yasuo Ida |
| 1437-1443 | Investigations into the Stabilization of Drugs by Sugar Glasses: III. The Influence of Various High-pH Buffers | Jonas H. C. Eriksson, Wouter L. J. Hinrichs, Gerhardus J. de Jong, Govert W. Somsen and Henderik W. Frijlink |
| 1444-1451 | PEGylated Adenoviruses for Gene Delivery to the Intestinal Epithelium by the Oral Route | Xuan Cheng, Xin Ming and Maria A. Croyle |
| 1452-1459 | Analysis of Hepatic Disposition of Galactosylated Cationic Liposome/Plasmid DNA Complexes in Perfused Rat Liver | Shintaro Fumoto, Fumi Nakadori, Shigeru Kawakami, Makiya Nishikawa and Fumiyoshi Yamashita, et al. |
| 1460-1465 | Intestinal Lymphatic Transport of Halofantrine Occurs After Oral Administration of a Unit-Dose Lipid-Based Formulation to Fasted Dogs | Shui-Mei Khoo, David M. Shackleford, Christopher J. H. Porter, Glenn A. Edwards and William N. Charman |
| 1466-1473 | Novel Gastroretentive Dosage Forms: Evaluation of Gastroretentivity and Its Effect on Levodopa Absorption in Humans | Eytan A. Klausner, Eran Lavy, Miklos Barta, Eva Cserepes and Michael Friedman, et al. |
| 1474-1484 | The Effect of Blood Sampling Site and Physicochemical Characteristics of Drugs on Bioavailability After Nasal Administration in the Sheep Model | L. Illum, M. Hinchcliffe and S. S. Davis |
| 1485-1495 | Evaluation of An Aerosolized Selective COX-2 Inhibitor as a Potentiator of Doxorubicin in a Non-Small-Cell Lung Cancer Cell Line | Alfred Haynes, Madhu Sudhan Shaik, Abhijit Chatterjee and M. Singh |
| 1496-1501 | Iontophoretic in Vivo Transdermal Delivery of β-Blockers in Hairless Rats and Reduced Skin Irritation by Liposomal Formulation | Rajkumar Conjeevaram, Ayyappa Chaturvedula, Guru V. Betageri, Gangadhar Sunkara and Ajay K. Banga |
| 1502-1507 | Effect of Vehicle Pretreatment on the Flux, Retention, and Diffusion of Topically Applied Penetrants in Vitro | Catarina Rosado, Sheree E. Cross, W. John Pugh, Michael S. Roberts and Jonathan Hadgraft |
| 1508-1513 | Transdermal Reverse Iontophoresis of Valproate: A Noninvasive Method for Therapeutic Drug Monitoring | M. Begoña Delgado-Charro and Richard H. Guy |
| 1514-1520 | Book Reviews |
| 1521-1522 | AAPS Update |
| 1523-1532 | Mechanism of Binding and Internalization of ICAM-1-Derived Cyclic Peptides by LFA-1 on the Surface of T Cells: A Potential Method for Targeted Drug Delivery | Meagan E. Anderson and Teruna J. Siahaan |
| 1533-1538 | pH-Triggered Release of Macromolecules from Spray-Dried Polymethacrylate Microparticles | Daniel S. Kohane, Daniel G. Anderson, Christine Yu and Robert Langer |
| 1539-1542 | Reduced Phagocytosis of Colloidal Carriers Using Soluble CD47 | Yu-Chih Hsu, Marcela Acuña, Stanley M. Tahara and Ching-An Peng |
| 1543-1550 | Engineering of Dendrimer Surfaces to Enhance Transepithelial Transport and Reduce Cytotoxicity | Rachaneekorn Jevprasesphant, Jeffrey Penny, David Attwood, Neil B. McKeown and Antony D'Emanuele |
| 1551-1557 | Pulmonary Absorption of Insulin Mediated by Tetradecyl-β-Maltoside and Dimethyl-β-Cyclodextrin | Alamdar Hussain, Tianzhi Yang, Abdel-Azim Zaghloul and Fakhrul Ahsan |
| 1558-1564 | Starlike vs. Classic Macromolecular Prodrugs: Two Different Antibody-Targeted HPMA Copolymers of Doxorubicin Studied in Vitro and in Vivo as Potential Anticancer Drugs | Markéta Jelínková, Jiří Strohalm, Tomáš Etrych, Karel Ulbrich and Blanka Říhová |
| 1565-1567 | Oligonucleotides Targeted Against a Junction Oncogene Are Made Efficient by Nanotechnologies | Andrei Maksimenko, Claude Malvy, Gregory Lambert, Jean-Rémy Bertrand and Elias Fattal, et al. |
| 1568-1573 | 9-cis-Retinoic Acid Regulation of Four UGT Isoforms in Hepatocytes from Rats with Various Thyroid States | Valérie Haberkorn, Lucie Oziol and Hervé Goudonnet |
| 1574-1580 | Correlation Among Agonist Dose, Rate of Import, and Transcriptional Activity of Liganded Progesterone Receptor B Isoform in Living Cells | Henan Li, Guang Yan, Steven E. Kern and Carol S. Lim |
| 1581-1590 | Sensitization of Cells Overexpressing Multidrug-Resistant Proteins by Pluronic P85 | Elena V. Batrakova, Shu Li, Valery Yu. Alakhov, William F. Elmquist and Donald W. Miller, et al. |
| 1591-1594 | The Hepatic and Intestinal Metabolic Activities of P450 in Rats with Surgery- and Drug-Induced Renal Dysfunction | Hiromi Okabe, Miyako Hasunuma and Yukiya Hashimoto |
| 1595-1599 | P-Glycoprotein Increases from Proximal to Distal Regions of Human Small Intestine | Stéphane Mouly and Mary F. Paine |
| 1600-1606 | Down-Regulation of Hepatic CYP3A in Chronic Renal Insufficiency | Bhaskar Rege, Richard Krieg, Ning Gao and Mohamadi A. Sarkar |
| 1607-1611 | In Vivo Saturation of the Transport of Vinblastine and Colchicine by P-Glycoprotein at the Rat Blood–Brain Barrier | Salvatore Cisternino, Christophe Rousselle, Marcel Debray and Jean-Michel Scherrmann |
| 1612-1618 | Effects of Fatty Acids and Iontophoresis on the Delivery of Midodrine Hydrochloride and the Structure of Human Skin | Yiping Wang, Qiuxi Fan, Yifan Song and Bozena Michniak |
| 1619-1625 | Skin Penetration and Mechanisms of Action in the Delivery of the D2-Agonist Rotigotine from Surfactant-Based Elastic Vesicle Formulations | P. Loan Honeywell-Nguyen, Sonia Arenja and Joke A. Bouwstra |
| 1626-1633 | Enhancement of Solubility and Bioavailability of β-Lapachone Using Cyclodextrin Inclusion Complexes | Norased Nasongkla, Andy F. Wiedmann, Andrew Bruening, Meghan Beman and Dale Ray, et al. |
| 1634-1640 | Solubility Prediction by Recursive Partitioning | Xiaoyang Xia, Edward Maliski, Janet Cheetham and Leszek Poppe |
| 1641-1646 | Use of a Physiologic Bicarbonate Buffer System for Dissolution Characterization of Ionizable Drugs | Daniel P. McNamara, Katherine M. Whitney and Sandra L. Goss |
| 1647-1654 | Determination of Glass Transition Temperature and in Situ Study of the Plasticizing Effect of Water by Inverse Gas Chromatography | Rahul Surana, Linda Randall, Abira Pyne, N. Murti Vemuri and Raj Suryanarayanan |
| 1655-1660 | Inactivation and Aggregation of β-Galactosidase in Lyophilized Formulation Described by Kohlrausch-Williams-Watts Stretched Exponential Function | Sumie Yoshioka, Shinsuke Tajima, Yukio Aso and Shigeo Kojima |
| 1661-1667 | Catanionic Drug–Surfactant Mixtures: Phase Behavior and Sustained Release from Gels | Tobias Bramer, Mattias Paulsson, Katarina Edwards and Katarina Edsman |
| 1668-1673 | Comparison of the Rates of Disintegration, Gastric Emptying, and Drug Absorption Following Administration of a New and a Conventional Paracetamol Formulation, Using γ Scintigraphy | Kilian Kelly, Bridget O'Mahony, Blythe Lindsay, Tamara Jones and Tim J. Grattan, et al. |
| 1674-1680 | In Vitro System to Evaluate Oral Absorption of Poorly Water-Soluble Drugs: Simultaneous Analysis on Dissolution and Permeation of Drugs | Makoto Kataoka, Yoshie Masaoka, Yukako Yamazaki, Toshiyasu Sakane and Hitoshi Sezaki, et al. |
| 1681-1689 | Design, Pharmacokinetic, and Pharmacodynamic Evaluation of a New Class of Soft Anticholinergics | Fenglei Huang, Clinton E. Browne, Whei-Mei Wu, Attila Juhász and Fubao Ji, et al. |
| 1690-1696 | Serially Passaged Human Nasal Epithelial Cell Monolayer for in Vitro Drug Transport Studies | Jin-Wook Yoo, You-Sun Kim, Sun-Hee Lee, Min-Ki Lee and Hwan-Jung Roh, et al. |
| 1697-1701 | Low Potential Ocular Irritation of Arginine-Based Gemini Surfactants and Their Mixtures with Nonionic and Zwitterionic Surfactants | Montserrat Mitjans, Verónica Martínez, Pere Clapés, Lourdes Pérez and M. Rosa Infante, et al. |
| 1702-1709 | Binding of Memantine to Melanin: Influence of Type of Melanin and Characteristics | Martin J. Koeberle, Patrick M. Hughes, Graham G. Skellern and Clive G. Wilson |
| 1710-1711 | AAPS Update |
| 1713-1720 | High-Throughput Proteomic-Based Identification of Oxidatively Induced Protein Carbonylation in Mouse Brain | Brian A. Soreghan, Frank Yang, Stefani N. Thomas, Jennifer Hsu and Austin J. Yang |
| 1721-1729 | Temperature- and pH-Induced Multiple Partially Unfolded States of Recombinant Human Interferon-α2a: Possible Implications in Protein Stability | Vikas K. Sharma and Devendra S. Kalonia |
| 1730-1737 | Gene Delivery in Tissue Engineering: A Photopolymer Platform to Coencapsulate Cells and Plasmid DNA | Deborah J. Quick and Kristi S. Anseth |
| 1738-1745 | A Fluorescent hPept1 Transporter Substrate for Uptake Screening | Christopher P. Landowski, Hyo-kyung Han, Kyung-Dall Lee and Gordon L. Amidon |
| 1746-1751 | Casein Enhances Stability of Peptides in Intestinal Lumen: Role of Digested Products of Casein | Seiji Ohtani, Ken-ichi Ogawara, Kazutaka Higaki and Toshikiro Kimura |
| 1752-1759 | The Use of Clinical Trial Simulation to Support Dose Selection: Application to Development of a New Treatment for Chronic Neuropathic Pain | Peter A. Lockwood, Jack A. Cook, Wayne E. Ewy and Jaap W. Mandema |
| 1760-1765 | Prediction of a Stable Microemulsion Formulation for the Oral Delivery of a Combination of Antitubercular Drugs Using ANN Methodology | Snezana Agatonovic-Kustrin, Beverley D. Glass, Michael H. Wisch and Raid G. Alany |
| 1766-1771 | A Physiologic Model for Simulating Gastrointestinal Flow and Drug Absorption in Rats | Stefan Willmann, Walter Schmitt, Jörg Keldenich and Jennifer B. Dressman |
| 1772-1778 | In Situ Blood–Brain Barrier Transport of Nanoparticles | Joanna M. Koziara, Paul R. Lockman, David D. Allen and Russell J. Mumper |
| 1779-1785 | Absence of Toxicity of Chronic Weekly Intravenous Gene Therapy with Pegylated Immunoliposomes | Yu-feng Zhang, Ruben J. Boado and William M. Pardridge |
| 1786-1793 | Novel Polysaccharide-Decorated Poly(Isobutyl Cyanoacrylate) Nanoparticles | Cédric Chauvierre, Denis Labarre, Patrick Couvreur and Christine Vauthier |
| 1794-1803 | Structural Determinants of P-Glycoprotein-Mediated Transport of Glucocorticoids | Charles R. Yates, Cheng Chang, Jeffrey D. Kearbey, Kazuto Yasuda and Erin G. Schuetz, et al. |
| 1804-1811 | Hypoxanthine Transport in Human Glioblastoma Cells and Effect on Cell Susceptibility to Methotrexate | Wei Kong and Joanne Wang |
| 1812-1819 | Uptake of Chitosan and Associated Insulin in Caco-2 Cell Monolayers: A Comparison Between Chitosan Molecules and Chitosan Nanoparticles | Zengshuan Ma and Lee-Yong Lim |
| 1820-1826 | In Vitro Permeability of Poorly Aqueous Soluble Compounds Using Different Solubilizers in the PAMPA Assay with Liquid Chromatography/Mass Spectrometry Detection | Hanlan Liu, Chantel Sabus, Guy T. Carter, Chao Du and Alex Avdeef, et al. |
| 1827-1834 | Determination of the Dermal Penetration of Esterom Components Using Microdialysis Sampling | Sarah McDonald and Craig Lunte |
| 1835-1837 | Unexpected Clobetasol Propionate Profile in Human Stratum Corneum After Topical Application in Vitro | Beat Mueller, Yuri G. Anissimov and Michael S. Roberts |
| 1838-1845 | Poly-l-Arginine Enhances Paracellular Permeability via Serine/Threonine Phosphorylation of ZO-1 and Tyrosine Dephosphorylation of Occludin in Rabbit Nasal Epithelium | Kazuo Ohtake, Takuya Maeno, Hideo Ueda, Masahiko Ogihara and Hideshi Natsume, et al. |
| 1846-1850 | High Bioavailability of α-Tocopherol Loaded into Poly (DL-Lactic-co-Glycolic Acid) Microspheres in Apolipoprotein B Knockout Mice | Koichi Yokogawa, Yuichiro Shima, Tomoka Hashimoto, Makoto Hiyajyo and Kaori Kadoyama, et al. |
| 1851-1857 | In situ Monitoring of Wet Granulation Using Online X-Ray Powder Diffraction | Tiffani D. Davis, Kenneth R. Morris, Huapeng Huang, Garnet E. Peck and Joseph G. Stowell, et al. |
| 1858-1863 | Solubilization of Cationic Drugs in Lung Surfactant | Xiangmin Liao and Timothy S. Wiedmann |
| 1864-1872 | PLGA/TPGS Nanoparticles for Controlled Release of Paclitaxel: Effects of the Emulsifier and Drug Loading Ratio | Li Mu and Si-Shen Feng |
| 1873-1880 | Improved α-Chymotrypsin Stability Upon Encapsulation in PLGA Microspheres by Solvent Replacement | Ingrid J. Castellanos and Kai Griebenow |
| 1881-1884 | Enantioselective Analysis of Ritalinic Acids in Biological Samples by Using a Protein-Based Chiral Stationary Phase | Jianhua Zhang, Yulin Deng, Jim Fang and Gordon McKay |
| 1885-1900 | Recommendations for the Bioanalytical Method Validation of Ligand-Binding Assays to Support Pharmacokinetic Assessments of Macromolecules | Binodh DeSilva, Wendell Smith, Russell Weiner, Marian Kelley and JoMarie Smolec, et al. |
| 1901-1902 | AAPS Electronic Scientist |
| 1903-1907 | Micelle-Associated Protein in Epoetin Formulations: A Risk Factor for Immunogenicity? | Suzanne Hermeling, Huub Schellekens, Daan J. A. Crommelin and Wim Jiskoot |
| 1908-1910 | Effects of Spermine-Conjugated Bowman-Birk Inhibitor (Spermine-BBI) on Carcinogenesis and Cholesterol Biosynthesis in Mice | Ann R. Kennedy, David Kritchevsky and Wei-Chiang Shen |
| 1911-1916 | Biophysical Evidence for His57 as a Proton-Binding Site in the Mammalian Intestinal Transporter hPepT1 | Tomomi Uchiyama, Ashutosh A. Kulkarni, Daryl L. Davies and Vincent H. L. Lee |
| 1917-1925 | Quantitative Biopharmaceutics Classification System: The Central Role of Dose/Solubility Ratio | Eleni Rinaki, Georgia Valsami and Panos Macheras |
| 1926-1931 | In Vitro Simulation of Solid-Solid Dehydration, Rehydration, and Solidification of Trehalose Dihydrate Using Thermal and Vibrational Spectroscopic Techniques | Shan-Yang Lin and Jui-Lung Chien |
| 1932-1938 | Quantitative Prediction of the Bitterness Suppression of Elemental Diets by Various Flavors Using a Taste Sensor | Yohko Miyanaga, Naoko Inoue, Ayako Ohnishi, Emi Fujisawa and Maki Yamaguchi, et al. |
| 1939-1945 | Crystallization of D-Mannitol in Binary Mixtures with NaCl: Phase Diagram and Polymorphism | Chitra Telang, Raj Suryanarayanan and Lian Yu |
| 1946-1951 | Transdermal Delivery of Timolol and Atenolol Using Electroporation and Iontophoresis in Combination: A Mechanistic Approach | Anne-Rose Denet, Bernard Ucakar and Véronique Préat |
| 1952-1960 | Influence of Histidine on the Stability and Physical Properties of a Fully Human Antibody in Aqueous and Solid Forms | Bei Chen, Raquel Bautista, Kwok Yu, Gerardo A. Zapata and Michael G. Mulkerrin, et al. |
| 1961-1969 | Development of a 7-Day, 96-Well Caco-2 Permeability Assay with High-Throughput Direct UV Compound Analysis | Jochem Alsenz and E. Haenel |
| 1970-1976 | Dry Powder Coating of Pellets with Micronized Eudragit® RS for Extended Drug Release | Nantharat Pearnchob and Roland Bodmeier |
| 1977-1983 | Radical Mechanisms in the Radiosterilization of Metoprolol Tartrate Solutions | Catherine Slegers, Gérard Baldacchino, Dominique Le Parc, Bernard Hickel and Bernard Tilquin |
| 1984-1988 | Concentration-Dependent Effects of Polyethylene Glycol 400 on Gastrointestinal Transit and Drug Absorption | Julia D. R. Schulze, Wendy A. Waddington, Peter J. Ell, Gary E. Parsons and Mark D. Coffin, et al. |
| 1989-1994 | In Vivo Evaluation of an Oral Salmon Calcitonin-Delivery System Based on a Thiolated Chitosan Carrier Matrix | Davide Guggi, Constantia E. Kast and Andreas Bernkop-Schnürch |
| 1995-2000 | Thermosensitive Hydrogel as a Tgf-β1 Gene Delivery Vehicle Enhances Diabetic Wound Healing | Pui-Yan Lee, Zhenhua Li and Leaf Huang |
| 2001-2007 | Magnetic Resonance Imaging for the in Vivo Evaluation of Gastric-Retentive Tablets | Andreas Steingoetter, Dominik Weishaupt, Patrick Kunz, Karsten Mäder and Hans Lengsfeld, et al. |
| 2008-2010 | Controlled Release of Insulin from Injectable Biodegradable Triblock Copolymer Depot in ZDF Rats | Suna Choi and Sung Wan Kim |
| 2011-2020 | Surfactant-Free, Biodegradable Nanoparticles for Aerosol Therapy Based on the Branched Polyesters, DEAPA-PVAL-g-PLGA | L. A. Dailey, E. Kleemann, M. Wittmar, T. Gessler and T. Schmehl, et al. |
| 2021-2027 | Novel Polymeric Micelles of Amphiphilic Triblock Copolymer Poly (p-Dioxanone-co-L-Lactide)-block-Poly (ethylene glycol) | Narayan Bhattarai, Shanta Raj Bhattarai, Ho Keun Yi, Jung Chang Lee and Myung Seob Khil, et al. |
| 2028-2035 | Generation of Fine Powders of Recombinant Human Deoxyribonuclease Using the Aerosol Solvent Extraction System | Rana T. Bustami, Hak-Kim Chan, Theresa Sweeney, Fariba Dehghani and Neil R. Foster |
| 2036-2040 | Effects of High Hydrostatic Pressure on Several Sensitive Therapeutic Molecules and a Soft Nanodispersed Drug Delivery System | Yohan Rigaldie, Alain Largeteau, Gilles Lemagnen, Fabienne Ibalot and Patrick Pardon, et al. |
| 2041-2051 | Book Reviews |
| 2052-2053 | AAPS Update |
| 2055-2059 | Author Index to Volume 20 (2003) |
| 2060-2066 | Subject Index to Volume 20 (2003) |
| 1-7 | Pharmaceutical Prospects for RNA Interference | Raymond M. Schiffelers, Martin C. Woodle and Puthupparampil Scaria |
| 8-14 | Strategies to Improve DNA Polyplexes for in Vivo Gene Transfer: Will “Artificial Viruses” Be the Answer? | Ernst Wagner |
| 15-25 | Vascular Endothelial Growth Factor Gene Delivery for Revascularization in Transplanted Human Islets | Ajit S. Narang, Kun Cheng, James Henry, Chunxiang Zhang and Omaima Sabek, et al. |
| 26-32 | A Cell Fractionation Approach for the Quantitative Analysis of Subcellular Drug Disposition | Muralikrishna Duvvuri, Wenhong Feng, Amanda Mathis and Jeffrey P. Krise |
| 33-42 | Cellular Internalization of Human Calcitonin Derived Peptides in MDCK Monolayers: A Comparative Study with Tat(47-57) and Penetratin(43-58) | Rachel Tréhin, Ulrike Krauss, Roman Muff, Martina Meinecke and Annette G. Beck-Sickinger, et al. |
| 43-49 | Effect of Chitosan on Epithelial Cell Tight Junctions | Jennifer Smith, Edward Wood and Michael Dornish |
| 50-54 | Biodegradable Triblock Copolymer of PLGA-PEG-PLGA Enhances Gene Transfection Efficiency | JiHoon Jeong, SungWan Kim and TaeGwan Park |
| 55-60 | Preparation and Characterization of Reconstructed Small Intestinal Brush Border Membranes for Surface Plasmon Resonance Analysis | Sungpil Cho, JaeHyung Park, Jaehoon Yu, Yong-Kyu Lee and Youngro Byun, et al. |
| 61-67 | Expression Levels of Renal Organic Anion Transporters (OATs) and Their Correlation with Anionic Drug Excretion in Patients with Renal Diseases | Yuji Sakurai, Hideyuki Motohashi, Harumasa Ueo, Satohiro Masuda and Hideyuki Saito, et al. |
| 68-82 | Bioavailability Prediction Based on Molecular Structure for a Diverse Series of Drugs | Joseph V. Turner, Desmond J. Maddalena and Snezana Agatonovic-Kustrin |
| 83-92 | Quantitative Structure-Permeation Relationships (QSPeRs) to Predict Skin Permeation: A Critical Evaluation | Sandrine Geinoz, Richard H. Guy, Bernard Testa and Pierre-Alain Carrupt |
| 93-100 | A G-Quadruplex Ligand 3,3′-Diethyloxadicarbocyanine Iodide Induces Mitochondrion-Mediated Apoptosis But Not Decrease of Telomerase Activity in Nasopharyngeal Carcinoma NPC-TW01 Cells | Chung-Pin Li, Jen-Hsin Huang, Ai-Chi Chang, Yi-Mei Hung and Chao-Hsiung Lin, et al. |
| 101-107 | Anticancer Drug Delivery with Transferrin Targeted Polymeric Chitosan Vesicles | Christine Dufes, Jean-Marc Muller, William Couet, Jean-Christophe Olivier and Ijeoma F. Uchegbu, et al. |
| 108-113 | Percutaneous Absorption and Anti-Inflammatory Effect of a Substance P Receptor Antagonist: Spantide II | R.Jayachandra Babu, Loice Kikwai, Lasha T. Jaiani, Narayanasamy Kanikkannan and Cheryl A. Armstrong, et al. |
| 114-120 | Pharmacodynamics of in Vivo Nitroglycerin Tolerance in Normal Conscious Rats: Effects of Dose and Dosing Protocol | Ellen Q. Wang, Joseph P. Balthasar and Ho-Leung Fung |
| 121-126 | Enhancing Immunogenicity and Reducing Dose of Microparticulated Synthetic Vaccines: Single Intradermal Administration | Ángel M. Carcaboso, Rosa M. Hernández, Manuela Igartua, Jaiver E. Rosas and Manuel E. Patarroyo, et al. |
| 127-135 | Local and Systemic Immune Responses to Intratracheal Instillation of Antigen and DNA Vaccines in Mice | Catherine Lombry, Aline Marteleur, Mohammed Arras, Dominique Lison and Jamila Louahed, et al. |
| 136-143 | Polymeric Drug Nanoparticles Prepared by an Aerosol Flow Reactor Method | Hannele Eerikäinen, Esko I. Kauppinen and Jarno Kansikas |
| 144-148 | Effect of Sodium Lauryl Sulfate in Dissolution Media on Dissolution of Hard Gelatin Capsule Shells | Fang Zhao, Vyacheslav Malayev, Venkatramana Rao and Munir Hussain |
| 149-159 | Use of Glancing Angle X-Ray Powder Diffractometry to Depth-Profile Phase Transformations During Dissolution of Indomethacin and Theophylline Tablets | Smita Debnath, Paul Predecki and Raj Suryanarayanan |
| 160-169 | Study of the Micellization Behavior of Different Order Amino Block Copolymers with Heparin | Marie-Hélène Dufresne and Jean-Christophe Leroux |
| 170-176 | Polymer Side-Chain Degradation as a Tool to Control the Destabilization of Polyplexes | Arjen M. Funhoff, Cornelus F. van Nostrum, Adriënne P. C. A. Janssen, Marcel H. A. M. Fens and Daan J. A. Crommelin, et al. |
| 177-184 | An Automated Approach to Salt Selection for New Unique Trazodone Salts | Emily C. Ware and D.Robert Lu |
| 185-188 | Solid-State Nuclear Magnetic Resonance Determination of the Physical Form of BHA on Common Pharmaceutical Excipients | Julius F. Remenar, Robert Wenslow, Drazen Ostovic and Andrey Peresypkin |
| 189-190 | AAPS Update |
| 191-200 | Design of Freeze-Drying Processes for Pharmaceuticals: Practical Advice | Xiaolin(Charlie) Tang and Michael J. Pikal |
| 201-230 | Solubilizing Excipients in Oral and Injectable Formulations | Robert G. Strickley |
| 231-236 | Inotropic Effect of Digoxin in Humans: Mechanistic Pharmacokinetic/Pharmacodynamic Model Based on Slow Receptor Binding | Michael Weiss and Wonku Kang |
| 237-244 | A Quantitative Structure-Property Relationship for Predicting Drug Solubility in PEG 400/Water Cosolvent Systems | Erik Rytting, Kimberley A. Lentz, Xue-Qing Chen, Feng Qian and Srini Venkatesh |
| 245-253 | Drug Solubilization Behavior During in Vitro Digestion of Simple Triglyceride Lipid Solution Formulations | AnnMarie Kaukonen, Ben J. Boyd, Christopher J. H. Porter and William N. Charman |
| 254-260 | Drug Solubilization Behavior During in Vitro Digestion of Suspension Formulations of Poorly Water-Soluble Drugs in Triglyceride Lipids | AnnMarie Kaukonen, Ben J. Boyd, William N. Charman and Christopher J. H. Porter |
| 261-270 | Enhanced Oral Absorption of Paclitaxel in a Novel Self-Microemulsifying Drug Delivery System with or Without Concomitant Use of P-Glycoprotein Inhibitors | Shicheng Yang, R. Neslihan Gursoy, Gregory Lambert and Simon Benita |
| 271-277 | Induction of Cell Death by Saponin and Antigen Delivery | Ching-An Wu and Ya-Wun Yang |
| 278-284 | The Transepithelial Transport of a G-CSF-Transferrin Conjugate in Caco-2 Cells and Its Myelopoietic Effect in BDF1 Mice | Adam Widera, Yun Bai and Wei-Chiang Shen |
| 285-292 | Esterase-Like Activity of Serum Albumin: Characterization of Its Structural Chemistry Using p-Nitrophenyl Esters as Substrates | Yuji Sakurai, Shen-Feng Ma, Hiroshi Watanabe, Noriyuki Yamaotsu and Shuichi Hirono, et al. |
| 293-299 | The “High Solubility” Definition of the Current FDA Guidance on Biopharmaceutical Classification System May Be Too Strict for Acidic Drugs | Mehran Yazdanian, Katherine Briggs, Corinne Jankovsky and Amale Hawi |
| 300-308 | Determination of Carrier-Mediated Transport of 2′,3′-Dideoxypurine Nucleosides in the Rat Ileum Using a Bidirectional Perfusion Technique | R.Tyler DeGraw and Bradley D. Anderson |
| 309-316 | In Situ Ileal Absorption of Insulin in Rats: Effects of Hyaluronidase Pretreatment Diminishing the Mucous/Glycocalyx Layers | Mariko Morishita, Yoshinobu Aoki, Masahiro Sakagami, Tsuneji Nagai and Kozo Takayama |
| 317-323 | Comparison of the AMPA Antagonist Action of New 2,3-Benzodiazepines in Vitro and Their Neuroprotective Effects in Vivo | Gábor Kapus, Szabolcs Kertész, Gábor Gigler, Annamária Simó and Miklos Vegh, et al. |
| 324-329 | N-Acetyltransferase 2 Genotype-Related Efficacy of Sulfasalazine in Patients with Rheumatoid Arthritis | Shunichi Kumagai, Fusao Komada, Tomoko Kita, Akio Morinobu and Shoichi Ozaki, et al. |
| 330-338 | Effect of Cisplatin-Induced Acute Renal Failure on Bioavailability and Intestinal Secretion of Quinolone Antibacterial Drugs in Rats | Hiroaki Yamaguchi, Ikuko Yano, Hideyuki Saito and Ken-ichi Inui |
| 339-343 | Biodegradable Triblock Copolymer Microspheres Based on Thermosensitive Sol-Gel Transition | YoungMin Kwon and SungWan Kim |
| 344-353 | Uptake and Cytotoxicity of Chitosan Molecules and Nanoparticles: Effects of Molecular Weight and Degree of Deacetylation | Min Huang, Eugene Khor and Lee-Yong Lim |
| 354-364 | Critical Determinants in PLGA/PLA Nanoparticle-Mediated Gene Expression | Swayam Prabha and Vinod Labhasetwar |
| 365-371 | Partial Acetylation of Polyethylenimine Enhances In Vitro Gene Delivery | M.Laird Forrest, Glenna E. Meister, James T. Koerber and Daniel W. Pack |
| 372-381 | Processing of Spherical Crystalline Particles via a Novel Solution Atomization and Crystallization by Sonication (SAXS) Technique | J.Sebastian Kaerger and Robert Price |
| 382-386 | Improved Tableting Properties of p-Hydroxybenzoic Acid by Water of Crystallization: A Molecular Insight | Changquan(Calvin) Sun and David J. W. Grant |
| 387-388 | AAPS Update |
| 389-393 | Cell Penetrating Peptides in Drug Delivery | Eric L. Snyder and Steven F. Dowdy |
| 394-399 | Comparison of Doxorubicin Concentration Profiles in Radiofrequency-Ablated Rat Livers from Sustained- and Dual-Release PLGA Millirods | Feng Qian, Nicholas Stowe, Gerald M. Saidel and Jinming Gao |
| 400-405 | Structural Characterization of Q10-Loaded Solid Lipid Nanoparticles by NMR Spectroscopy | Sylvia A. Wissing, Rainer H. Müller, Lars Manthei and Christian Mayer |
| 406-412 | Chemosensitivity Assessed by Collagen Gel Droplet Embedded Culture Drug Sensitivity Test, and MDR1, MRP1, and MRP2 mRNA Expression in Human Colorectal Adenocarcinomas | Takako Nakahara, Toshiyuki Sakaeda, Tsutomu Nakamura, Takao Tamura and Chiharu Nishioka, et al. |
| 413-419 | A Novel Evaluation Method of Gastric Mucoadhesive Property in Vitro and the Mucoadhesive Mechanism of Tetracycline-Sucralfate Acidic Complex for Eradication of Helicobacter pylori | Shoichi Higo, Kazutomo Ori, Hirofumi Takeuchi, Hiromitsu Yamamoto and Tomoaki Hino, et al. |
| 420-427 | In Vitro Studies of the Effects of HAART Drugs and Excipients on Activity of Digestive Enzymes | Terese M. Wignot, Roger P. Stewart, Keith J. Schray, Simantini Das and Tibor Sipos |
| 428-435 | Oxidation of Hantzsch 1,4-Dihydropyridines of Pharmacological Significance by Electrogenerated Superoxide | M.E. Ortiz, L.J. Núñez-Vergara, C. Camargo and J.A. Squella |
| 436-442 | Factors Responsible for the Variability of Saquinavir Absorption: Studies Using an Instrumented Dog Model | Nuzhat Tam-Zaman, Yun K. Tam, Soheir Tawfik and Hugh Wiltshire |
| 443-446 | Assessment of Lumiracoxib Bioavailability from Targeted Sites in the Human Intestine Using Remotely Activated Capsules and Gamma Scintigraphy | Ian R. Wilding, Alyson L. Connor, Polly Carpenter, Christiane Rordorf and Janice Branson, et al. |
| 447-453 | Differential Adhesion of Normal and Inflamed Rat Colonic Mucosa by Charged Liposomes | TareqTaha Jubeh, Yechezkel Barenholz and Abraham Rubinstein |
| 454-457 | In situ-Forming Pharmaceutical Organogels Based on the Self-Assembly of L-Alanine Derivatives | Anne-Claude Couffin-Hoarau, Aude Motulsky, Pascal Delmas and Jean-Christophe Leroux |
| 458-466 | Evaluation of Generation 2 and 3 Poly(Propylenimine) Dendrimers for the Potential Cellular Delivery of Antisense Oligonucleotides Targeting the Epidermal Growth Factor Receptor | Andrew J. Hollins, Mustapha Benboubetra, Yadollah Omidi, Bernd H. Zinselmeyer and Andreas G. Schatzlein, et al. |
| 467-475 | ATP-Dependent Transport of a Novel Thromboxane A2 Receptor Antagonist, [2-(4-Chlorophenylsulfonylaminomethyl)-Indan-5-yl]Acetate (Z-335) and Its Xenobiotic Taurine Conjugate (Z-335-Tau) by Rat Bile Canalicular Membrane Vesicles | Yoshihiro Kawabata, Emiko Kamada, Shigeru Furuta, Mineo Takei and Tadashi Kurimoto, et al. |
| 476-483 | 3H Dendrimer Nanoparticle Organ/Tumor Distribution | Shraddha S. Nigavekar, LokYun Sung, Mikel Llanes, Areej El-Jawahri and Theodore S. Lawrence, et al. |
| 484-491 | In Vitro/in Vivo Correlation for 14C-Methylated Lysozyme Release from Poly(Ether-Ester) Microspheres | R. van Dijkhuizen-Radersma, S.J. Wright, L.M. Taylor, B.A. John and K. de Groot, et al. |
| 492-499 | Lactose Surface Modification by Decantation: Are Drug-Fine Lactose Ratios the Key to Better Dispersion of Salmeterol Xinafoate from Lactose-Interactive Mixtures? | Nazrul Islam, Peter Stewart, Ian Larson and Patrick Hartley |
| 500-506 | Poly(Lactide-Co-Glycolide) Microsphere Formulations of Darbepoetin Alfa: Spray Drying Is an Alternative to Encapsulation by Spray-Freeze Drying | Paul A. Burke, Lisa A. Klumb, John D. Herberger, Xichdao C. Nguyen and Roy A. Harrell, et al. |
| 507-514 | Protein Powders for Encapsulation: A Comparison of Spray-Freeze Drying and Spray Drying of Darbepoetin Alfa | Xichdao C. Nguyen, John D. Herberger and Paul A. Burke |
| 515-523 | Spray-Coating for Biopharmaceutical Powder Formulations: Beyond the Conventional Scale and Its Application | Yuh-Fun Maa, Mahmoud Ameri, Robert Rigney, Lendon G. Payne and Dexiang Chen |
| 524-535 | Preparation of Large Porous Deslorelin-PLGA Microparticles with Reduced Residual Solvent and Cellular Uptake Using a Supercritical Carbon Dioxide Process | Kavitha Koushik and Uday B. Kompella |
| 536-542 | Statistical Evaluation of Vial Design Features That Influence Sublimation Rates During Primary Drying | Anthony Cannon and Kerryann Shemeley |
| 543-552 | Book Reviews | Kinam Park |
| 553-554 | AAPS Update |
| 555-566 | Neonatal Exposure to Drugs in Breast Milk | Patrick J. McNamara and Maggie Abbassi |
| 567-573 | Hematological Response of Topotecan in Tumor-Bearing Rats: Modeling of the Time Course of Different Cellular Populations | Cristina Segura, Eva Bandrés, Iñaki F. Trocóniz, Jesús García-Foncillas and Onintza Sayar, et al. |
| 574-584 | Population Pharmacokinetic Modeling of a Subcutaneous Depot for GnRH Antagonist Degarelix | Christoffer W. Tornøe, Henrik Agersø, Henrik A. Nielsen, Henrik Madsen and E. Niclas Jonsson |
| 585-591 | A Dynamic Artificial Gastrointestinal System for Studying the Behavior of Orally Administered Drug Dosage Forms Under Various Physiological Conditions | Stéphanie Blanquet, Evelijn Zeijdner, Erick Beyssac, Jean-Philippe Meunier and Sylvain Denis, et al. |
| 592-597 | Investigation on Particle Self-Assembly in Solid Lipid-Based Colloidal Drug Carrier Systems | Andreas Illing, Tobias Unruh and Michel H. J. Koch |
| 598-607 | Molecular Reactivity of Busulfan Through Its Experimental Electrostatic Properties in the Solid State | NourEddine Ghermani, Anne Spasojević-de Biré, Nouzha Bouhmaida, Souad Ouharzoune and Jérôme Bouligand, et al. |
| 608-616 | Impact of Tether Length on Bone Mineral Affinity of Protein-Bisphosphonate Conjugates | Sébastien A. Gittens, Pavel I. Kitov, John R. Matyas, Raimar Löbenberg and Hasan Uludağ |
| 617-624 | Correlation and Prediction of Moisture-Mediated Dissolution Stability for Benazepril Hydrochloride Tablets | Shoufeng Li, Bill Wei, Santo Fleres, Ann Comfort and Alan Royce |
| 625-634 | Contribution of Cholesterol and Phospholipids to Inhibitory Effect of Dimethyl-β-Cyclodextrin on Efflux Function of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 in Vinblastine-Resistant Caco-2 Cell Monolayers | Hidetoshi Arima, Kiyokazu Yunomae, Tadatoshi Morikawa, Fumitoshi Hirayama and Kaneto Uekama |
| 635-640 | d-Glucose Triggers Multidrug Resistance–Associated Protein (MRP)-Mediated Secretion of Fluorescein Across Rat Jejunum in Vitro | Igor Legen and Albin Kristl |
| 641-648 | The Characteristics and Mechanisms of Uptake of PLGA Nanoparticles in Rabbit Conjunctival Epithelial Cell Layers | Mohamed G. Qaddoumi, Hideo Ueda, Johnny Yang, Jasmine Davda and Vinod Labhasetwar, et al. |
| 649-660 | Modulation of AP-1 by Natural Chemopreventive Compounds in Human Colon HT-29 Cancer Cell Line | Woo-Sik Jeong, In-Wha Kim, Rong Hu and Ah-Ng Tony Kong |
| 661-670 | Modulatory Properties of Various Natural Chemopreventive Agents on the Activation of NF-κB Signaling Pathway | Woo-Sik Jeong, In-Wha Kim, Rong Hu and Ah-Ng Tony Kong |
| 671-674 | Novel Chitosan Particles and Chitosan-Coated Emulsions Inducing Immune Response via Intranasal Vaccine Delivery | Takahiro Nagamoto, Yoshiyuki Hattori, Kozo Takayama and Yoshie Maitani |
| 675-682 | Effective Transfection of Rabies DNA Vaccine in Cell Culture Using an Artificial Lipoprotein Carrier System | Fars Alanazi, Zhen F. Fu and D.Robert Lu |
| 683-691 | Stabilized Nonviral Formulations for the Delivery of MCP-1 Gene into Cells of the Vasculoendothelial System | Martin C. Lenter, Patrick Garidel, Jaroslav Pelisek, Ernst Wagner and Manfred Ogris |
| 692-694 | Transport of Clonidine at Cultured Epithelial Cells (JEG-3) of the Human Placenta | Johanna Müller, Reinhard Neubert and Matthias Brandsch |
| 695-705 | In Vivo Phage Display to Identify M Cell-Targeting Ligands | Lisa M. Higgins, Imelda Lambkin, Graham Donnelly, Daragh Byrne and Carolyn Wilson, et al. |
| 706-716 | Spinal Disposition and Meningeal Permeability of Local Anesthetics | Rozenn Clément, Jean-Marc Malinovsky, Patrice Hildgen, Gilles Dollo and JeanPierre Estèbe, et al. |
| 717-718 | AAPS Update |
| 719-735 | The Complexities of Hepatic Drug Transport: Current Knowledge and Emerging Concepts | Priyamvada Chandra and Kim L. R. Brouwer |
| 736-741 | Sp1-Dependent Regulation of the RTP801 Promoter and Its Application to Hypoxia-Inducible VEGF Plasmid for Ischemic Disease | Minhyung Lee, Malavosklish Bikram, Seungjoon Oh, David A. Bull and SungWan Kim |
| 742-748 | Characterization of the Cellular Localization, Expression Level, and Function of SNP Variants of MRP2/ABCC2 | Masakazu Hirouchi, Hiroshi Suzuki, Masaya Itoda, Shogo Ozawa and Jun-ichi Sawada, et al. |
| 749-755 | Correction of Permeability with Pore Radius of Tight Junctions in Caco-2 Monolayers Improves the Prediction of the Dose Fraction of Hydrophilic Drugs Absorbed by Humans | Ryoichi Saitoh, Kiyohiko Sugano, Noriyuki Takata, Tatsuhiko Tachibana and Atsuko Higashida, et al. |
| 756-760 | Transport Screening of Drug Cocktails Through an in Vitro Blood-Brain Barrier: Is It a Good Strategy for Increasing the Throughput of the Discovery Pipeline? | V. Berezowski, C. Landry, S. Lundquist, L. Dehouck and R. Cecchelli, et al. |
| 761-769 | Characterization and Modulation of the Transferrin Receptor on Brain Capillary Endothelial Cells | Corine C. Visser, L.Heleen Voorwinden, Daan J. A. Crommelin, Meindert Danhof and Albertus G. de Boer |
| 770-776 | Ocular Pharmacokinetic/Pharmacodynamic Modeling for Bunazosin After Instillation into Rabbits | Koji Sakanaka, Kouichi Kawazu, Masahide Tomonari, Takashi Kitahara and Mikiro Nakashima, et al. |
| 777-780 | Analysis of Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics Data Sets Using VizStruct, a Novel Multidimensional Visualization Technique | Kavitha Bhasi, Li Zhang, Aidong Zhang and Murali Ramanathan |
| 781-784 | Urinary Excretion: Does It Accurately Reflect Relative Differences in Bioavailability/Systemic Exposure When Renal Clearance Is Nonlinear? | Gary A. Thompson and Roger D. Toothaker |
| 785-792 | Comparison of the Use of Liver Models for Predicting Drug Clearance Using in Vitro Kinetic Data from Hepatic Microsomes and Isolated Hepatocytes | Kiyomi Ito and J.Brian Houston |
| 793-798 | In Vitro and in Vivo Pharmacoscintigraphic Evaluation of Ibuprofen Hypromellose and Gelatin Capsules | Ewart T. Cole, Robert A. Scott, Dominique Cade, Alyson L. Connor and Ian R. Wilding |
| 799-802 | Uptake of Melatonin into the Cerebrospinal Fluid After Nasal and Intravenous Delivery: Studies in Rats and Comparison with a Human Study | Mascha P. van den Berg, Paul Merkus, Stefan G. Romeijn, J.Coos Verhoef and Frans W. H. M. Merkus |
| 803-810 | Chitosan Nanoparticles as New Ocular Drug Delivery Systems: in Vitro Stability, in Vivo Fate, and Cellular Toxicity | Angela M. de Campos, Yolanda Diebold, Edison L. S. Carvalho, Alejandro Sánchez and Maria José Alonso |
| 811-818 | Involvement of P-Glycoprotein in the Transport of Saquinavir and Indinavir in Rat Brain Microvessel Endothelial and Microglia Cell Lines | Patrick T. Ronaldson, Gloria Lee, Shannon Dallas and Reina Bendayan |
| 819-826 | Predicting P-Glycoprotein Effects on Oral Absorption: Correlation of Transport in Caco-2 with Drug Pharmacokinetics in Wild-Type and mdr1a(-/-) Mice in Vivo | Andrew Collett, Jolanta Tanianis-Hughes, David Hallifax and Geoff Warhurst |
| 827-831 | Control of Blood Glucose by Novel GLP-1 Delivery Using Biodegradable Triblock Copolymer of PLGA-PEG-PLGA in Type 2 Diabetic Rats | Suna Choi, Miroslav Baudys and SungWan Kim |
| 832-837 | Sustained Intravesical Drug Delivery Using Thermosensitive Hydrogel | Pradeep Tyagi, Zhenhua Li, Michael Chancellor, William C. De Groat and Naoki Yoshimura, et al. |
| 838-843 | A Method for Oral DNA Delivery with N-Acetylated Chitosan | Eriko Kai and Takahiro Ochiya |
| 844-850 | Transdermal Iontophoresis of Rotigotine Across Human Stratum Corneum in Vitro: Influence of pH and NaCl Concentration | AkhmadKharis Nugroho, GaiLing Li, Meindert Danhof and Joke A. Bouwstra |
| 851-859 | On-Line Visualization of Dye Diffusion in Fresh Unfixed Human Skin | Ylva Y. Grams, Lynne Whitehead, Paul Cornwell and Joke A. Bouwstra |
| 860-866 | Modeling and Monitoring of Polymorphic Transformations During the Drying Phase of Wet Granulation | Tiffani D. Davis, Garnet E. Peck, Joseph G. Stowell, Kenneth R. Morris and Stephen R. Byrn |
| 867-874 | Effect of Aging on the Physical Properties of Amorphous Trehalose | Rahul Surana, Abira Pyne and Raj Suryanarayanan |
| 875-881 | A New Wet Conductivimetric Method to Estimate the Drug Percolation Threshold | Álvaro Espina-Márquez and Isidoro Caraballo |
| 882-890 | Polymer Blends Used for the Coating of Multiparticulates: Comparison of Aqueous and Organic Coating Techniques | Florence Lecomte, Juergen Siepmann, Mathias Walther, Ross J. MacRae and Roland Bodmeier |
| 891-894 | Oxaliplatin Degradation in the Presence of Chloride: Identification and Cytotoxicity of the Monochloro Monooxalato Complex | Elin Jerremalm, Mikael Hedeland, Inger Wallin, Ulf Bondesson and Hans Ehrsson |
| 895-896 | AAPS Update |
| 897-903 | Structure-Immunogenicity Relationships of Therapeutic Proteins | Suzanne Hermeling, Daan J. A. Crommelin, Huub Schellekens and Wim Jiskoot |
| 904-913 | Functional Implications of Genetic Polymorphisms in the Multidrug Resistance Gene MDR1 (ABCB1) | Christiane Pauli-Magnus and Deanna L. Kroetz |
| 914-919 | In Vitro Delivery of Novel, Highly Potent Anti-Varicella Zoster Virus Nucleoside Analogues to Their Target Site in the Skin | Chris A. Jarvis, Chris McGuigan and Charles M. Heard |
| 920-926 | A Real-Time in Vitro Assay for Studying Functional Characteristics of Target-Specific Ultrasound Contrast Agents | Shiba Joseph, Carsten Olbrich, Julia Kirsch, Michael Hasbach and Andreas Briel, et al. |
| 927-931 | Design of Amine-Modified Graft Polyesters for Effective Gene Delivery Using DNA-Loaded Nanoparticles | Christine G. Oster, Matthias Wittmar, Florian Unger, Lucian Barbu-Tudoran and Andreas K. Schaper, et al. |
| 932-939 | Biodistribution Characteristics of Galactosylated Emulsions and Incorporated Probucol for Hepatocyte-Selective Targeting of Lipophilic Drugs in Mice | Emi Ishida, Chittima Managit, Shigeru Kawakami, Makiya Nishikawa and Fumiyoshi Yamashita, et al. |
| 940-946 | Topical Delivery of a Model Phenolic Drug: Alkyloxycarbonyl Prodrugs of Acetaminophen | Scott C. Wasdo and Kenneth B. Sloan |
| 947-952 | Transdermal Delivery of Insulin Using Microneedles in Vivo | Wijaya Martanto, Shawn P. Davis, Nicholas R. Holiday, Jenny Wang and Harvinder S. Gill, et al. |
| 953-961 | An Atomic Force Microscopy Study of the Effect of Nanoscale Contact Geometry and Surface Chemistry on the Adhesion of Pharmaceutical Particles | Jennifer C. Hooton, Caroline S. German, Stephanie Allen, Martyn C. Davies and Clive J. Roberts, et al. |
| 962-968 | A Novel One-Step Drug-Loading Procedure for Water-Soluble Amphiphilic Nanocarriers | Elvire Fournier, Marie-Hélène Dufresne, Damon C. Smith, Maxime Ranger and Jean-Christophe Leroux |
| 969-975 | Decreased Activity and Expression of Intestinal Oligopeptide Transporter PEPT1 in Rats with Hyperthyroidism in Vivo | Kayoko Ashida, Toshiya Katsura, Hideyuki Saito and Ken-ichi Inui |
| 976-981 | Creatinine Transport by Basolateral Organic Cation Transporter hOCT2 in the Human Kidney | Yumiko Urakami, Naoko Kimura, Masahiro Okuda and Ken-ichi Inui |
| 982-988 | Renal Secretion of the Antiviral Nucleoside Analog AM188 Is Inhibited by Probenecid, p-Aminohippuric Acid, and Cimetidine in the Isolated Perfused Rat Kidney | Jiping Wang, Roger L. Nation, Allan M. Evans and Susan Cox |
| 989-995 | Effect of Gonadectomy and Hormones on Sex Differences in Ketoprofen Enantiomer Glucuronidation and Renal Excretion of Formed Glucuronides in the Rat | Eugenia L. Palylyk-Colwell and Fakhreddin Jamali |
| 996-999 | In Vitro and in Vivo Trans-Esterification of 1-[2(R)-(2-Amino-2-Methylpropionylamino)-3-(1H-Indol-3-yl)Propionyl]-3(S)-Benzyl-Piperidine-3-Carboxylic Acid Ethyl Ester and the Effects of Ethanol on Its Pharmacokinetics in Rats | Zhesheng Chen, Arun K. Agrawal, Ronald B. Franklin, Kwan H. Leung and Shuet-HingLee Chiu |
| 1000-1008 | Effects of Duration of Ischemia and Donor Pretreatment with Methylprednisolone or Its Macromolecular Prodrug on the Disposition of Indocyanine Green in Cold-Preserved Rat Livers | Anjaneya P. Chimalakonda and Reza Mehvar |
| 1009-1017 | Transfection Efficiency and Cytotoxicity of Nonviral Gene Transfer Reagents in Human Smooth Muscle and Endothelial Cells | Karin Kiefer, Jule Clement, Patrick Garidel and Regine Peschka-Süss |
| 1018-1025 | Coating of Mannan on LPD Particles Containing HPV E7 Peptide Significantly Enhances Immunity Against HPV-Positive Tumor | Zhengrong Cui, Su-Ji Han and Leaf Huang |
| 1026-1033 | The Permeability and Cytotoxicity of Insulin-Mimetic Vanadium Compounds | Xiao-Gai Yang, Xiao-Da Yang, Lan Yuan, Kui Wang and Debbie C. Crans |
| 1034-1046 | Evidence for LHRH-Receptor Expression in Human Airway Epithelial (Calu-3) Cells and Its Role in the Transport of an LHRH Agonist | Kavitha Koushik, Nagesh Bandi, Sneha Sundaram and Uday B. Kompella |
| 1047-1054 | Simple Rules Defining the Potential of Compounds for Transdermal Delivery or Toxicity | Beatrice M. Magnusson, W.John Pugh and Michael S. Roberts |
| 1055-1064 | Pharmacokinetic Analysis of Ramatroban Using a Recirculatory Model with Enterohepatic Circulation by Measuring Portal and Systemic Blood Concentration Difference in Sprague-Dawley and Eisai Hyperbilirubinemic Rats | Toshiya Moriwaki, Hiroyuki Yasui and Akira Yamamoto |
| 1065-1076 | Book Reviews | Kinam Park |
| 1077-1078 | AAPS Electronic Scientist | Sandra E. Hawken |
| 1079-1086 | RAGE: A Novel Target for Drug Intervention in Diabetic Vascular Disease | Barry I. Hudson and AnnMarie Schmidt |
| 1087-1093 | Opalescent Appearance of an IgG1 Antibody at High Concentrations and Its Relationship to Noncovalent Association | Muppalla Sukumar, Brandon L. Doyle, Jessica L. Combs and Allen H. Pekar |
| 1094-1102 | Rapid Characterization of Amyloid-β Side-Chain Oxidation by Tandem Mass Spectrometry and the Scoring Algorithm for Spectral Analysis | Alexandra J. Schiewe, Lawrence Margol, Brian A. Soreghan, Stefani N. Thomas and Austin J. Yang |
| 1103-1109 | HPLC Detection and Quantification of Radiolytic Products of Eight β-Blockers Irradiated in the Solid State and Hypotheses on Their Origins | Alix Engalytcheff, Jean-Paul Vanhelleputte and Bernard Tilquin |
| 1109-1118 | Suppression of the Progress of Disseminated Pancreatic Cancer Cells by NK4 Plasmid DNA Released from Cationized Gelatin Microspheres | Toshihiro Kushibiki, Kunio Matsumoto, Toshikazu Nakamura and Yasuhiko Tabata |
| 1119-1126 | Pulmonary Delivery of Deslorelin: Large-Porous PLGA Particles and HPβCD Complexes | Kavitha Koushik, Devender S. Dhanda, Narayan P. S. Cheruvu and Uday B. Kompella |
| 1127-1136 | Cyclodextrins in Nasal Delivery of Low-Molecular-Weight Heparins: In Vivo and in Vitro Studies | Tianzhi Yang, Alamdar Hussain, Jennifer Paulson, Thomas J. Abbruscato and Fakhrul Ahsan |
| 1137-1145 | Transdermal Delivery of the Synthetic Cannabinoid WIN 55,212-2: In Vitro/in Vivo Correlation | Satyanarayana Valiveti, Dana C. Hammell, D.Caroline Earles and Audra L. Stinchcomb |
| 1146-1152 | Physicochemical Evaluation, in Vitro Human Skin Diffusion, and Concurrent Biotransformation of 3-O-Alkyl Carbonate Prodrugs of Naltrexone | Omathanu Pillai, Mohamed O. Hamad, Peter A. Crooks and Audra L. Stinchcomb |
| 1153-1159 | Technetium-99m-Labeled N-(2-Hydroxypropyl) Methacrylamide Copolymers: Synthesis, Characterization, and in Vivo Biodistribution | Amitava Mitra, Anjan Nan, Hamidreza Ghandehari, Edwina McNeil and Justin Mulholland, et al. |
| 1160-1166 | Lectins as Endocytic Ligands: An Assessment of Lectin Binding and Uptake to Rabbit Conjunctival Epithelial Cells | Mohamed Qaddoumi and Vincent H. L. Lee |
| 1167-1176 | Effect of Preparation Method on Physical Properties of Amorphous Trehalose | Rahul Surana, Abira Pyne and Raj Suryanarayanan |
| 1177-1183 | Development of Dividable One-Step Dry-Coated Tablets (Dividable-OSDRC) and Their Evaluation as a New Platform for Controlled Drug Release | Yuichi Ozeki, Yukinao Watanabe, Hirokazu Okamoto and Kazumi Danjo |
| 1184-1191 | Preparation and Drug Loading of Poly(Ethylene Glycol)-block-Poly(ε-Caprolactone) Micelles Through the Evaporation of a Cosolvent Azeotrope | Karen K. Jette, Devalina Law, Eric A. Schmitt and Glen S. Kwon |
| 1192-1199 | Rheological Characterization of Topical Carbomer Gels Neutralized to Different pH | Mohammad T. Islam, Naír Rodríguez-Hornedo, Susan Ciotti and Chrisita Ackermann |
| 1200-1206 | Aerosol Dispersion of Respirable Particles in Narrow Size Distributions Produced by Jet-Milling and Spray-Drying Techniques | Margaret D. Louey, Michiel Van Oort and Anthony J. Hickey |
| 1207-1213 | Aerosol Dispersion of Respirable Particles in Narrow Size Distributions Using Drug-Alone and Lactose-Blend Formulations | Margaret D. Louey, Michiel Van Oort and Anthony J. Hickey |
| 1214-1222 | Reverse Iontophoresis as a Noninvasive Tool for Lithium Monitoring and Pharmacokinetic Profiling | Benoît Leboulanger, Marc Fathi, Richard H. Guy and M.Begoña Delgado-Charro |
| 1223-1228 | Significant Role of Liver Sinusoidal Endothelial Cells in Hepatic Uptake and Degradation of Naked Plasmid DNA After Intravenous Injection | Jin Hisazumi, Naoki Kobayashi, Makiya Nishikawa and Yoshinobu Takakura |
| 1229-1232 | A New Potent hFIX Plasmid for Hemophilia B Gene Therapy | JeoungSoo Lee, Minhyung Lee and SungWan Kim |
| 1233-1238 | Surface Plasmon Resonance Studies of the Direct Interaction Between a Drug/Intestinal Brush Border Membrane | Kwangmeyung Kim, Sungpil Cho, JaeHyung Park, Youngro Byun and Hesson Chung, et al. |
| 1240-1247 | Composition and Surface Charge of DNA-Loaded Microparticles Determine Maturation and Cytokine Secretion in Human Dendritic Cells | Samantha Jilek, Michael Ulrich, Hans P. Merkle and Elke Walter |
| 1248-1256 | Cellular Uptake But Low Permeation of Human Calcitonin-Derived Cell Penetrating Peptides and Tat(47-57) Through Well-Differentiated Epithelial Models | Rachel Tréhin, Ulrike Krauss, Annette G. Beck-Sickinger, Hans P. Merkle and Hanne M. Nielsen |
| 1257-1262 | Uptake of the Carborane Derivative of Cholesteryl Ester by Glioma Cancer Cells Is Mediated Through LDL Receptors | Guangliang Pan, Svein Øie and D.Robert Lu |
| 1263-1273 | Combined Effects of Multiple Flavonoids on Breast Cancer Resistance Protein (ABCG2)-Mediated Transport | Shuzhong Zhang, Xinning Yang and Marilyn E. Morris |
| 1274-1283 | Mishandling of the Therapeutic Peptide Glucagon Generates Cytotoxic Amyloidogenic Fibrils | Satomi Onoue, Keiichi Ohshima, Kazuhiro Debari, Keitatsu Koh and Seiji Shioda, et al. |
| 1284-1293 | P-glycoprotein (P-gp/MDR1)-Mediated Efflux of Sex-Steroid Hormones and Modulation of P-gp Expression In Vitro | Winnie Y. Kim and Leslie Z. Benet |
| 1294-1302 | P-glycoprotein Expression, Localization, and Function in Sandwich-Cultured Primary Rat and Human Hepatocytes: Relevance to the Hepatobiliary Disposition of a Model Opioid Peptide | Keith A. Hoffmaster, Ryan Z. Turncliff, Edward L. LeCluyse, Richard B. Kim and Peter J. Meier, et al. |
| 1303-1310 | Transport of Amino Acid Esters and the Amino-Acid-Based Prodrug Valganciclovir by the Amino Acid Transporter ATB0,+ | Nagavedi S. Umapathy, Vadivel Ganapathy and Malliga E. Ganapathy |
| 1311-1312 | AAPS Electronic Scientist |
| 1313-1330 | Functional Expression and Localization of P-glycoprotein in the Central Nervous System: Relevance to the Pathogenesis and Treatment of Neurological Disorders | Gloria Lee and Reina Bendayan |
| 1331-1344 | The Role of Metabolites in Bioequivalence | Kamal K. Midha, Maureen J. Rawson and John W. Hubbard |
| 1345-1352 | A Compartment Model for the Membrane-Coated Fiber Technique Used for Determining the Absorption Parameters of Chemicals into Lipophilic Membranes | Xin-Rui Xia, Ronald E. Baynes, Nancy A. Monteiro-Riviere and Jim E. Riviere |
| 1353-1361 | Use of Biophysical Characterization in Preformulation Development of a Heavy-Chain Fragment of Botulinum Serotype B: Evaluation of Suitable Purification Process Conditions | Frank K. Bedu-Addo, Catharine Johnson, Shanthini Jeyarajah, Ian Henderson and Siddharth J. Advant |
| 1362-1373 | Effects of the Chemical Structure and the Surface Properties of Polymeric Biomaterials on Their Biocompatibility | You-Xiong Wang, John L. Robertson, William B. Spillman and Richard O. Claus |
| 1374-1381 | Characterization and In Vivo Study of Sustained-Release Formulation of Human Growth Hormone Using Sodium Hyaluronate | Sei Kwang Hahn, Sun Jin Kim, Myung Jin Kim and Duk Hee Kim |
| 1382-1389 | In Situ Transport of Vinblastine and Selected P-glycoprotein Substrates: Implications for Drug-Drug Interactions at the Mouse Blood-Brain Barrier | Salvatore Cisternino, Christophe Rousselle, Marcel Debray and Jean-Michel Scherrmann |
| 1390-1397 | Porcine Ear Skin as a Model for the Assessment of Transdermal Drug Delivery to Premature Neonates | Nabila Sekkat, Yogeshvar N. Kalia and Richard H. Guy |
| 1398-1404 | Transport Characteristics of Fexofenadine in the Caco-2 Cell Model | Niclas Petri, Christer Tannergren, David Rungstad and Hans Lennernäs |
| 1405-1412 | Susceptibility to Lipase-Mediated Digestion Reduces the Oral Bioavailability of Danazol After Administration as a Medium-Chain Lipid-Based Microemulsion Formulation | Christopher J. H. Porter, Ann Marie Kaukonen, Ben J. Boyd, Glenn A. Edwards and William N. Charman |
| 1413-1418 | Influence of the Type of Surfactant and the Degree of Dispersion on the Lymphatic Transport of Halofantrine in Conscious Rats | Ditte M. Karpf, René Holm, Henning G. Kristensen and Anette Müllertz |
| 1419-1427 | Solvent Exchange Method: A Novel Microencapsulation Technique Using Dual Microdispensers | Yoon Yeo, Alvin U. Chen, Osman A. Basaran and Kinam Park |
| 1428-1439 | Physicochemical Parameters Associated with Nanoparticle Formation in the Salting-Out, Emulsification-Diffusion, and Nanoprecipitation Methods | Sergio Galindo-Rodriguez, Eric Allémann, Hatem Fessi and Eric Doelker |
| 1440-1444 | Inverse Gas Chromatography: Investigating Whether the Technique Preferentially Probes High Energy Sites for Mixtures of Crystalline and Amorphous Lactose | Helen E. Newell and Graham Buckton |
| 1445-1449 | Hydrophilic Microspheres from Water-in-Oil Emulsions by the Water Diffusion Technique | Michele Trotta, Daniela Chirio, Roberta Cavalli and Elena Peira |
| 1450-1456 | Identification of Stabilized Dynorphin Derivatives for Suppressing Tolerance in Morphine-Dependent Rats | Suliman I. Al-Fayoumi, Boglarka Brugos, Vikram Arya, Esther Mulder and Barbel Eppler, et al. |
| 1457-1462 | Evaluating Barriers to Bioavailability in Vivo: Validation of a Technique for Separately Assessing Gastrointestinal Absorption and Hepatic Extraction | Laura Letendre, Mark Scott, Glenn Dobson, Ismael Hidalgo and Bruce Aungst |
| 1463-1470 | Population Dose-Response Model for Tadalafil in the Treatment of Male Erectile Dysfunction | Alexander Staab, Christiane Tillmann, S. Thomas Forgue, Alison Mackie and Sandra R. B. Allerheiligen, et al. |
| 1471-1479 | Enhancement of Transfection Efficiency Through Rapid and Noncovalent Post-PEGylation of Poly(Dimethylaminoethyl Methacrylate)/DNA Complexes | Sabine Pirotton, Caroline Muller, Nadège Pantoustier, François Botteman and Sébastien Collinet, et al. |
| 1480-1488 | How Well Can an Idiotope Peptide Mimic Replace Its Parent Idiotype in a Synthetic Peptide Vaccine? | James S. Cavenaugh, Hsu-Kun Wang, Jiang Sha, Corey Hansen and Kongnara Papangkorn, et al. |
| 1489-1497 | Evidence for Modulation of P-glycoprotein-Mediated Efflux by Methoxypolyethylene Glycol-block-Polycaprolactone Amphiphilic Diblock Copolymers | Jason Zastre, John Jackson and Helen Burt |
| 1498-1504 | The Mechanism of Protraction of Insulin Detemir, a Long-Acting, Acylated Analog of Human Insulin | Svend Havelund, Anne Plum, Ulla Ribel, Ib Jonassen and Aage Vølund, et al. |
| 1505-1516 | Insertion and Partition of Sodium Taurocholate into Egg Phosphatidylcholine Vesicles | Karine Andrieux, Laura Forte, Sylviane Lesieur, Maité Paternostre and Michel Ollivon, et al. |
| 1517-1518 | AAPS Update |
| 1519-1530 | Novel Approaches to Vaccine Delivery | Derek T. O'Hagan and Rino Rappuoli |
| 1531-1538 | Peroxisome Proliferator-Activated Receptor (PPAR)-α: A Pharmacological Target with a Promising Future | Daniel H. van Raalte, Min Li, P. Haydn Pritchard and Kishor M. Wasan |
| 1539-1544 | An Automated Method for the Determination of Montelukast in Human Plasma Using Dual-Column HPLC Analysis and Peak Height Summation of the Parent Compound and Its Photodegradation Product | Glenn A. Smith, Cynthia M. Rawls and Robert L. Kunka |
| 1545-1553 | Insulin Nanoparticles: A Novel Formulation Approach for Poorly Water Soluble Zn-Insulin | Elaine Merisko-Liversidge, Simon L. McGurk and Gary G. Liversidge |
| 1554-1557 | The Use of Inverse Phase Gas Chromatography to Study the Glass Transition Temperature of a Powder Surface | Graham Buckton, Ameet Ambarkhane and Kim Pincott |
| 1558-1563 | Influence of 5-Fluorouracil-Loaded Microsphere Formulation on Efficient Rat Glioma Radiosensitization | Valérie-Gaëlle Roullin, Martine Mege, Laurent Lemaire, Jean-Pierre Cueyssac and Marie-Claire Venier-Julienne, et al. |
| 1564-1566 | Heat-Treated Fungizone Retains Amphotericin B Antifungal Activity Without Renal Toxicity in Rats Infected with Aspergillus Fumigatus | Olena Sivak, Karen Bartlett and Kishor M. Wasan |
| 1567-1572 | Identification of Biowaivers Among Class II Drugs: Theoretical Justification and Practical Examples | Eleni Rinaki, Aristides Dokoumetzidis, Georgia Valsami and Panos Macheras |
| 1573-1580 | Design and Evaluation of an Emulsion Vehicle for Paclitaxel. I. Physicochemical Properties and Plasma Stability | Jihong Han, Stanley S. Davis, Catherine Papandreou, Colin D. Melia and Clive Washington |
| 1581-1590 | Biodegradable Self-Assembling PEG-Copolymer as Vehicle for Poorly Water-Soluble Drugs | Louisa Ould-Ouali, Albertina Ariën, Joel Rosenblatt, Aruna Nathan and Patricia Twaddle, et al. |
| 1591-1597 | The Cohesive-Adhesive Balances in Dry Powder Inhaler Formulations I: Direct Quantification by Atomic Force Microscopy | Philippe Begat, David A.V. Morton, John N. Staniforth and Robert Price |
| 1598-1606 | Phase Behavior of Amorphous Molecular Dispersions I: Determination of the Degree and Mechanism of Solid Solubility | Madhav Vasanthavada, Wei-Qin Tong, Yatindra Joshi and M. Serpil Kislalioglu |
| 1607-1614 | Characterization of Suspension-Based Metered Dose Inhaler Formulations Composed of Spray-Dried Budesonide Microcrystals Dispersed in HFA-134a | Thomas E. Tarara, Michael S. Hartman, Howard Gill, Alan A. Kennedy and Jeffry G. Weers |
| 1615-1621 | Effect of pH, Counter Ion, and Phosphate Concentration on the Glass Transition Temperature of Freeze-Dried Sugar-Phosphate Mixtures | Satoshi Ohtake, Carolina Schebor, Sean P. Palecek and Juan J. de Pablo |
| 1622-1630 | Metabolism and Disposition of the HIV-1 Protease Inhibitor Lopinavir (ABT-378) Given in Combination with Ritonavir in Rats, Dogs, and Humans | Gondi N. Kumar, Venkata K. Jayanti, Marianne K. Johnson, John Uchic and Samuel Thomas, et al. |
| 1631-1636 | Tamoxifen Alters Hepatic Cytochrome P450 Enzyme Expression and Circulating Growth Hormone Levels in Intact Male Rats | Ludger M. Ickenstein, Susan L. Holsmer and Stelvio M. Bandiera |
| 1637-1641 | Assessment of the Potential Skin Irritation of Lysine-Derivative Anionic Surfactants Using Mouse Fibroblasts and Human Keratinocytes as An Alternative to Animal Testing | L. Sanchez, M. Mitjans, M.R. Infante and M.P. Vinardell |
| 1642-1647 | Isothermal Titration Calorimetric Study of RNase-A Kinetics (cCMP → 3'-CMP) Involving End-Product Inhibition | Shawn D. Spencer and Robert B. Raffa |
| 1648-1655 | Tryptophan Residues Play an Important Role in the Extraordinarily High Affinity Binding Interaction of UCN-01 to Human α-1-Acid Glycoprotein | Masaaki Katsuki, Victor Tuan Giam Chuang, Koji Nishi, Ayaka Suenaga and Masaki Otagiri |
| 1656-1661 | Polyelectrolyte Nanoparticles Mediate Vascular Gene Delivery | Sergey Zaitsev, Régis Cartier, Oleg Vyborov, Gleb Sukhorukov and Bernd-Reiner Paulke, et al. |
| 1662-1669 | Application of Novel Solid Lipid Nanoparticle (SLN)-Gene Vector Formulations Based on a Dimeric HIV-1 TAT-Peptide in Vitro and in Vivo | Carsten Rudolph, Ulrike Schillinger, Aurora Ortiz, Kerstin Tabatt and Christian Plank, et al. |
| 1670-1679 | In Vitro and in Vivo Metabolism of the Anti-Cancer Agent CI-1040, a MEK Inhibitor, in Rat, Monkey, and Human | Paul A. Wabnitz, David Mitchell and David A.M. Wabnitz |
| 1680-1685 | Role of PEPT2 in the Choroid Plexus Uptake of Glycylsarcosine and 5-Aminolevulinic Acid: Studies in Wild-Type and Null Mice | Scott M. Ocheltree, Hong Shen, Yongjun Hu, Jianming Xiang and Richard F. Keep, et al. |
| 1686-1691 | Interactions of Human P-glycoprotein with Simvastatin, Simvastatin Acid, and Atorvastatin | Jerome H. Hochman, Nicole Pudvah, Julia Qiu, Masayo Yamazaki and Cuyue Tang, et al. |
| 1692-1697 | Formulation Optimization of Paclitaxel Carried by PEGylated Emulsions Based on Artificial Neural Network | Tianyuan Fan, Kozo Takayama, Yoshiyuki Hattori and Yoshie Maitani |
| 1698-1707 | An Integrated Model for the Analysis of Pharmacokinetic Data from Microdialysis Experiments | Karin Tunblad, Margareta Hammarlund-Udenaes and E. Niclas Jonsson |
| 1708-1717 | Early Prediction of Pharmaceutical Oxidation Pathways by Computational Chemistry and Forced Degradation | Darren L. Reid, C. Jeffrey Calvitt, Mark T. Zell, Kenneth G. Miller and Carol A. Kingsmill |
| 1718-1720 | Letter to Editor: Use of Inverse Gas Chromatography (IGC) to Determine the Surface Energy and Surface Area of Powdered Materials | D. Cline and R. Dalby |
| 1721-1722 | AAPS Update |
| 1723-1724 | Reviewers for Pharmaceutical Research (Volume 20) for the Period of Novemver 1, 2002 and October 31, 2003 |
| 1725-1731 | The Value of USP Public Standards for Therapeutic Products | L. Bhattacharyya, T. Cecil, R. Dabbah, D. Roll and S. Schuber, et al. |
| 1732-1740 | “Programmed Polymeric Devices” for Pulsed Drug Delivery | Barbara G. Stubbe, Stefaan C. De Smedt and Joseph Demeester |
| 1741-1749 | The Arthrotropism of Macromolecules in Adjuvant-Induced Arthritis Rat Model: A Preliminary Study | Dong Wang, Scott C. Miller, Monika Sima, Dennis Parker and Henry Buswell, et al. |
| 1750-1757 | Reactivity of 1,4-Dihydropyridines Toward SIN-1-Derived Peroxynitrite | C. L#x00F3;pez-Alarc#x00F3;n, H. Speisky, J. A. Squella, C. Olea-Azar and C. Camargo, et al. |
| 1758-1761 | Miniature Device for Aqueous and Non-aqueous Solubility Measurements During Drug Discovery | Xue-Qing Chen and Srini Venkatesh |
| 1762-1769 | Stability and Solubility of Celecoxib-PVP Amorphous Dispersions: A Molecular Perspective | Piyush Gupta, Vasu Kumar Kakumanu and Arvind K. Bansal |
| 1770-1775 | Extended Nasal Residence Time of Lysostaphin and an Anti-Staphylococcal Monoclonal Antibody by Delivery in Semisolid or Polymeric Carriers | Scott Walsh, John Kokai-Kun, Anjali Shah and James Mond |
| 1776-1782 | Effect of Gender and Device Mouthpiece Shape on Bolus Insulin Aerosol Delivery Using the AERx Pulmonary Delivery System | Brooks Boyd, Peter Noymer, Kui Liu, Jerry Okikawa and Dave Hasegawa, et al. |
| 1783-1789 | Novel Long-Circulating Lipid Nanocapsules | Didier Hoarau, Pascal Delmas, St#x00E9;phanie David, Emmanuelle Roux and Jean-Christophe Leroux |
| 1790-1796 | Transforming Growth Factor (TGF)-β1 Releasing Tricalcium Phosphate/Chitosan Microgranules as Bone Substitutes | Jue-Yeon Lee, Yang-Jo Seol, Kyoung-Hwa Kim, Yong-Moo Lee and Yoon-Jeong Park, et al. |
| 1797-1804 | Retinal Delivery of Celecoxib Is Several-Fold Higher Following Subconjunctival Administration Compared to Systemic Administration | Surya P. Ayalasomayajula and Uday B. Kompella |
| 1805-1810 | Simultaneous Extraction of Urea and Glucose by Reverse Iontophoresis in Vivo | Anke Sieg, Richard H. Guy and M. Bego#x00F1;a Delgado-Charro |
| 1811-1817 | Influence of Spinline Stress on Release Properties of a Coaxial Controlled Release Device Based on EVA Polymers | Hans van Laarhoven, Jan Veurink, Marc-Anton Kruft and Herman Vromans |
| 1818-1825 | Enhancement of Topical Delivery from Biodegradable Nanoparticles | Roc#x00ED;o Alvarez-Rom#x00E1;n, Aarti Naik, Yogeshvar N. Kalia, Richard H. Guy and Hatem Fessi |
| 1826-1833 | The Cohesive-Adhesive Balances in Dry Powder Inhaler Formulations II: Influence on Fine Particle Delivery Characteristics | Philippe Begat, David A. V. Morton, John N. Staniforth and Robert Price |
| 1834-1843 | Supercooled Smectic Nanoparticles: A Potential Novel Carrier System for Poorly Water Soluble Drugs | J. Kuntsche, K. Westesen, M. Drechsler, M. H. J. Koch and H. Bunjes |
| 1844-1851 | The Potential of Raman Spectroscopy as a Process Analytical Technique During Formulations of Topical Gels and Emulsions | Mohammad T. Islam, Na#x00ED;r Rodr#x00ED;guez-Hornedo, Susan Ciotti and Chrisita Ackermann |
| 1852-1861 | Amphiphilogels for Drug Delivery: Formulation and Characterization | Nadeen Jibry, Richard K. Heenan and Sudaxshina Murdan |
| 1862-1866 | Comparative Effects on Intestinal Absorption in Situ by P-glycoprotein-Modifying HIV Protease Inhibitors | Martin Richter, N#x00F3;ra Gy#x00E9;m#x00E1;nt, Jos#x00E9;f Moln#x00E1;r and Andreas Hilgeroth |
| 1867-1870 | Use of Loperamide as a Phenotypic Probe of mdr1a Status in CF-1 Mice | J. Cory Kalvass, Candace L. Graff and Gary M. Pollack |
| 1871-1879 | Phototoxicity of 5-Aminolevulinic Acid in the HeLa Cell Line as an Indicative Measure of Photodynamic Effect After Topical Administration to Gynecological Lesions of Intraepithelial Form | Paul A. McCarron, Ryan F. Donnelly, Brendan F. Gilmore, A. David Woolfson and Raymond McClelland, et al. |
| 1880-1885 | Enhancement of the Efficacy of An Antagonist of an Extracellular Receptor by Attachment to the Surface of a Biocompatible Carrier | Charles A. Wartchow, Susan E. Alters, Pamela D. Garzone, Lingyun Li and Steven Choi, et al. |
| 1886-1894 | Screening of the Interaction Between Xenobiotic Transporters and PDZ Proteins | Yukio Kato, Kazuhiro Yoshida, Chizuru Watanabe, Yoshimichi Sai and Akira Tsuji |
| 1895-1903 | Functional Analysis of SNPs Variants of BCRP/ABCG2 | Chihiro Kondo, Hiroshi Suzuki, Masaya Itoda, Shogo Ozawa and Jun-ichi Sawada, et al. |
| 1904-1916 | Effects of Extracts of Commonly Consumed Food Supplements and Food Fractions on the Permeability of Drugs Across Caco-2 Cell Monolayers | Leena A. Laitinen, P#x00E4;ivi S. M. Tammela, Anna Galkin, Heikki J. Vuorela and Martti L. A. Marvola, et al. |
| 1917-1923 | Binding and Uptake of Wheat Germ Agglutinin-Grafted PLGA-Nanospheres by Caco-2 Monolayers | Andrea Weissenboeck, Elisabeth Bogner, Michael Wirth and Franz Gabor |
| 1924-1932 | Functional Analysis of Recombinant Human Serum Albumin Domains for Pharmaceutical Applications | Sadaharu Matsushita, Yu Isima, Victor Tuan Giam Chuang, Hiroshi Watanabe and Sumio Tanase, et al. |
| 1933-1942 | Novel Scaled Average Bioequivalence Limits Based on GMR and Variability Considerations | Vangelis Karalis, Mira Symillides and Panos Macheras |
| 1943-1952 | Book Reviews | Randall J. Mrsny |
| 1953-1954 | AAPS Update |
| 1955-1969 | Stabilization of Proteins in Dry Powder Formulations Using Supercritical Fluid Technology | Nataša Jovanović, Andréanne Bouchard, Gerard W. Hofland, Geert-Jan Witkamp and Daan J. A. Crommelin, et al. |
| 1970-1973 | Stable Transfection of MDCK Cells with Epitope-Tagged Human PepT1 | Chun Chu, Curtis T. Okamoto, Sarah F. Hamm-Alvarez and Vincent H. L. Lee |
| 1974-1984 | Compartmental Modeling of Transdermal Iontophoretic Transport: I. In Vitro Model Derivation and Application | Akhmad Kharis Nugroho, Oscar Della Pasqua, Meindert Danhof and Joke A. Bouwstra |
| 1985-1992 | Transferrin-Oligomers as Potential Carriers in Anticancer Drug Delivery | Ching-Jou Lim and Wei-Chiang Shen |
| 1993-2000 | Effects of Pluronic P85 on GLUT1 and MCT1 Transporters in the Blood-Brain Barrier | Elena V. Batrakova, Yan Zhang, Yili Li, Shu Li and Sergei V. Vinogradov, et al. |
| 2001-2008 | Block Copolymer Design for Camptothecin Incorporation into Polymeric Micelles for Passive Tumor Targeting | Praneet Opanasopit, Masayuki Yokoyama, Masato Watanabe, Kumi Kawano and Yoshie Maitani, et al. |
| 2009-2016 | Pulmonary Delivery of Low Molecular Weight Heparins | Tianzhi Yang, Fatima Mustafa, Shuhua Bai and Fakhrul Ahsan |
| 2017-2024 | In Vivo ESR Studies on Subcutaneously Injected Multilamellar Liposomes in Living Mice | Klaus-Peter Moll, Reinhard Stößer, Werner Herrmann, Hans-Hubert Borchert and Hideo Utsumi |
| 2025-2030 | A Mechanistic Investigation of an Amorphous Pharmaceutical and Its Solid Dispersions, Part I: A Comparative Analysis by Thermally Stimulated Depolarization Current and Differential Scanning Calorimetry | Rama A. Shmeis, Zeren Wang and Steven L. Krill |
| 2031-2039 | A Mechanistic Investigation of An Amorphous Pharmaceutical and Its Solid Dispersions, Part II: Molecular Mobility and Activation Thermodynamic Parameters | Rama A. Shmeis, Zeren Wang and Steven L. Krill |
| 2040-2047 | Formulating Insulin for Oral Administration: Preparation of Hyaluronan-Insulin Complex | Gustaf Jederstrom, Arne Andersson, Johan Gråsjö and Ingvar Sjöholm |
| 2048-2057 | Development and Characterization of a Scalable Controlled Precipitation Process to Enhance the Dissolution of Poorly Water-Soluble Drugs | True L. Rogers, Ian B. Gillespie, James E. Hitt, Kevin L. Fransen and Cindy A. Crowl, et al. |
| 2058-2063 | Suramin as a Chemosensitizer: Oral Pharmacokinetics in Rats | Adam Ogden, M. Guillaume Wientjes and Jessie L.-S. Au |
| 2064-2071 | Pharmacokinetics of Teicoplanin in An ICU Population of Children and Infants | John C Lukas, Georgios Karikas, Maria Gazouli, Panagiotis Kalabalikis and Tasos Hatzis, et al. |
| 2072-2078 | Pharmacokinetic and Biodistribution Profile of Recombinant Human Interleukin-10 Following Intravenous Administration in Rats with Extensive Liver Fibrosis | Heni Rachmawati, Leonie Beljaars, Catharina Reker-Smit, Anne-miek M. Van Loenen-Weemaes and Werner I. Hagens, et al. |
| 2079-2084 | A Novel Oral Vehicle for Poorly Soluble HSV-Helicase Inhibitors: PK/PD Validations | Jianmin Duan, Francine Liard, William Paris and Michelle Lambert |
| 2085-2094 | Effects of An E-cadherin-Derived Peptide on the Gene Expression of Caco-2 Cells | Anna Maria Calcagno, Jennifer M. Fostel, Eric L. Reyner, Ernawati Sinaga and James T. Alston, et al. |
| 2095-2104 | Potential Beneficial Metabolic Interactions Between Tamoxifen and Isoflavones via Cytochrome P450-mediated Pathways in Female Rat Liver Microsomes | Jun Chen, Steven C. Halls, Joshua F. Alfaro, Zhaohui Zhou and Ming Hu |
| 2105-2111 | Albubnp, a Recombinant B-type Natriuretic Peptide and Human Serum Albumin Fusion Hormone, as a Long-Term Therapy of Congestive Heart Failure | Wei Wang, Ying Ou and Yanggu Shi |
| 2112-2119 | Polyacetylenes Function as Anti-Angiogenic Agents | Li-Wha Wu, Yi-Ming Chiang, Hsiao-Ching Chuang, Sheng-Yang Wang and Ga-Wen Yang, et al. |
| 2120-2126 | Enteric Excretion of Baicalein, a Flavone of Scutellariae Radix, via Glucuronidation in Rat: Involvement of Multidrug Resistance-Associated Protein 2 | Teruaki Akao, Yoko Sakashita, Masato Hanada, Hirozo Goto and Yutaka Shimada, et al. |
| 2127-2132 | Eudragit E Accelerated the Diketopiperazine Formation of Enalapril Maleate Determined by Thermal FTIR Microspectroscopic Technique | Shun-Li Wang, Shan-Yang Lin, Ting-Fang Chen and Wen-Ting Cheng |
| 2133-2134 | Transporter Database, TP-Search: A Web-Accessible Comprehensive Database for Research in Pharmacokinetics of Drugs | Naoki Ozawa, Takako Shimizu, Rika Morita, Yoshiya Yokono and Takafumi Ochiai, et al. |
| 2135-2136 | AAPS Update |
| 2137-2147 | Foreign Particles Testing in Orally Inhaled and Nasal Drug Products | James Blanchard, James Coleman, Claire D’Abreu Hayling, Raouf Ghaderi and Barbara Haeberlin, et al. |
| 2148-2152 | Adsorption of a Novel Recombinant Glycoprotein from HIV (Env gp120dV2 SF162) to Anionic PLG Microparticles Retains the Structural Integrity of the Protein, Whereas Encapsulation in PLG Microparticles Does Not | Manmohan Singh, James Chesko, Jina Kazzaz, Mildred Ugozzoli and Elaine Kan, et al. |
| 2153-2157 | A Folate Receptor–Targeted Lipid Nanoparticle Formulation for a Lipophilic Paclitaxel Prodrug | Phillip J. Stevens, Masaru Sekido and Robert J. Lee |
| 2158-2166 | The Rate of Drug Particle Detachment from Carrier Crystals in an Air Classifier-Based Inhaler | Anne H. de Boer, Paul Hagedoorn, Doetie Gjaltema, Dorette Lambregts and Meike Irngartinger, et al. |
| 2167-2174 | The Mode of Drug Particle Detachment from Carrier Crystals in an Air Classifier-Based Inhaler | Anne H. de Boer, Paul Hagedoorn, Doetie Gjaltema, Dorette Lambregts and Meike Irngartinger, et al. |
| 2175-2184 | Assessment of Subconjunctival Delivery with Model Ionic Permeants and Magnetic Resonance Imaging | S. Kevin Li, Sarah A. Molokhia and Eun-Kee Jeong |
| 2185-2195 | Hyperbranched Polymer-Drug Conjugates with High Drug Payload for Enhanced Cellular Delivery | Parag Kolhe, Jayant Khandare, Omathanu Pillai, Sujatha Kannan and Mary Lieh-Lai, et al. |
| 2196-2206 | Oral Absorption Enhancement of Cromolyn Sodium Through Noncovalent Complexation | Xuan Ding, Parshuram Rath, Robert Angelo, Thomas Stringfellow and Elizabeth Flanders, et al. |
| 2207-2212 | Prophylactic Role of Liposomized Chloroquine Against Murine Cryptococcosis Less Susceptible to Fluconazole | Masood A. Khan, Rukhsana Jabeen and Owais Mohammad |
| 2213-2218 | Aerosol Profile Extracted from Spacers as a Determinant of Actual Dose | Sylvia Verbanck, Chris Vervaet, Daniël Schuermans and Walter Vincken |
| 2219-2225 | Topical Delivery of Anti-sense Oligonucleotides Using Low-Frequency Sonophoresis | Ahmet Tezel, Sujatha Dokka, Susan Kelly, Gregory E. Hardee and Samir Mitragotri |
| 2226-2233 | Effect of Pluronic P85 on ATPase Activity of Drug Efflux Transporters | Elena V. Batrakova, Shu Li, Yili Li, Valery Yu. Alakhov and Alexander V. Kabanov |
| 2234-2246 | Pharmacokinetics and Biodistribution of Novel Aptamer Compositions | Judith M. Healy, Scott D. Lewis, Markus Kurz, Ryan M. Boomer and Kristin M. Thompson, et al. |
| 2247-2252 | In Vitro Metabolism of 5-ALA Esters Derivatives in Hairless Mice Skin Homogenate and in Vivo PpIX Accumulation Studies | Fernanda Scarmato De Rosa, Renata Fonseca Vianna Lopez, José Antônio Thomazine, Antônio Cláudio Tedesco and Norbert Lange, et al. |
| 2253-2260 | Effect of Oil-in-Water Emulsions on 5-Aminolevulinic Acid Uptake and Metabolism to PpIX in Cultured MCF-7 Cells | Hanne Mørck Nielsen, Caroline Aemisegger, Gerd Burmeister, Ursula Schuchter and Bruno Gander |
| 2261-2269 | Effect of Organic Isothiocyanates on Breast Cancer Resistance Protein (ABCG2)-Mediated Transport | Yan Ji and Marilyn E. Morris |
| 2270-2278 | Studies of Binding Modes of (S)-Mephenytoin to Wild Types and Mutants of Cytochrome P450 2C19 and 2C9 Using Homology Modeling and Computational Docking | Akifumi Oda, Noriyuki Yamaotsu and Shuichi Hirono |
| 2279-2292 | Area/Moment and Compartmental Modeling of Pharmacokinetics During Pregnancy: Applications to Maternal/Fetal Exposures to Corticosteroids in Sheep and Rats | Mahesh N. Samtani, Matthias Schwab, Peter W. Nathanielsz and William J. Jusko |
| 2293-2299 | Response Surface Methodology to Investigate the Iontophoretic Delivery of Tacrine Hydrochloride | Rashmi S. Upasani and Ajay K. Banga |
| 2300-2306 | Reexamination of Convective Diffusion/Drug Dissolution in a Laminar Flow Channel: Accurate Prediction of Dissolution Rate | Paul J. Missel, Larry E. Stevens and John W. Mauger |
| 2307-2319 | Marine Alkaloid Polycarpine and Its Synthetic Derivative Dimethylpolycarpine Induce Apoptosis in JB6 Cells Through p53- and Caspase 3-Dependent Pathways | Sergey N. Fedorov, Ann M. Bode, Valentin A. Stonik, Irina A. Gorshkova and Patricia C. Schmid, et al. |
| 2320-2326 | Stimulation of Triglyceride-Rich Lipoprotein Secretion by Polysorbate 80: In Vitro and in Vivo Correlation Using Caco-2 Cells and a Cannulated Rat Intestinal Lymphatic Model | Fergal Seeballuck, Emma Lawless, Marianne B. Ashford and Caitriona M. O’Driscoll |
| 2327-2335 | Interaction of Basic Drugs with Lipid Bilayers Using Liposome Electrokinetic Chromatography | Jennifer M. Carrozzino and Morteza G. Khaledi |
| 2336-2339 | Unidirectional Inhibition of Lipid Transfer Protein I-Mediated Transfer of Cholesteryl Esters Between High-Density and Low-Density Lipoproteins by Amphotericin B Lipid Complex | Olena Sivak, Benny Lau, Nilesh Patankar and Kishor M. Wasan |
| 2340-2346 | Long-Term Stability of Chitosan-Based Polyplexes | Kristine Romøren, Astrid Aaberge, Gro Smistad, Beate J. Thu and Øystein Evensen |
| 2347-2353 | Characterization of Mixtures of Alkyl Polyglycosides (Plantacare) by Liquid Chromatography-Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry | Andrea V. Kühn and Reinhard H. H. Neubert |
| 2354-2359 | Complex Coacervation of Lysozyme and Heparin: Complex Characterization and Protein Stability | Marco van de Weert, Mia Bendix Andersen and Sven Frokjaer |
| 2360-2368 | A Novel Preformulation Tool to Group Microcrystalline Celluloses Using Artificial Neural Network and Data Clustering | Josephine L. P. Soh, Fei Chen, Celine V. Liew, Daming Shi and Paul W. S. Heng |
| 2369-2376 | Effects of Hydrophilic Cyclodextrins on Aggregation of Recombinant Human Growth Hormone | Sumitra Tavornvipas, Shinichiro Tajiri, Fumitoshi Hirayama, Hidetoshi Arima and Kaneto Uekama |
| 2377-2383 | Effects of Antioxidants on the Hydrogen Peroxide-Mediated Oxidation of Methionine Residues in Granulocyte Colony-Stimulating Factor and Human Parathyroid Hormone Fragment 13-34 | Jin Yin, Jhih-Wei Chu, Margaret Speed Ricci, David N. Brems and Daniel I. C. Wang, et al. |
| 2384-2391 | Preparation of PLGA Microparticles by an Emulsion-Extraction Process Using Glycofurol as Polymer Solvent | Anne Aubert-Pouëssel, Marie-Claire Venier-Julienne, Patrick Saulnier, Michelle Sergent and Jean-Pierre Benoît |
| 2392-2393 | AAPS Update |
| 2394-2398 | Author Index to Volume 21 (2004) |
| 2399-2403 | Subject Index to Volume 21 (2004) |
| 173-174 | Pharmaceutical Sciences, Scientist, and Journals—A Tribute to Pharmaceutical Research for Its Coming of Age | Bernard Testa |
| 175-181 | Bioadhesive Dosage Forms for Esophageal Drug Delivery | Hannah Batchelor |
| 182-187 | Oral Dosage Form Performance Tests: New Dissolution Approaches | Walter W. Hauck, Thomas Foster, Eric Sheinin, Todd Cecil and William Brown, et al. |
| 188-192 | pH-Dependent Dissolution in Vitro and Absorption in Vivo of Weakly Basic Drugs: Development of a Canine Model | Rong Zhou, Paul Moench, Christopher Heran, Xujin Lu and Neil Mathias, et al. |
| 193-199 | FK506 Microparticles Mitigate Experimental Colitis with Minor Renal Calcineurin Suppression | Alf Lamprecht, Hiromitsu Yamamoto, Nathalie Ubrich, Hirofumi Takeuchi and Philippe Maincent, et al. |
| 200-208 | A Polymeric Nanoparticle Consisting of mPEG-PLA-Toco and PLMA-COONa as a Drug Carrier: Improvements in Cellular Uptake and Biodistribution | Yilwoong Yi, Jae Hong Kim, Hye-Won Kang, Hun Seung Oh and Sung Wan Kim, et al. |
| 209-219 | Engineering Polysaccharide-Based Polymeric Micelles to Enhance Permeability of Cyclosporin A Across Caco-2 Cells | Mira F. Francis, Mariana Cristea, Yali Yang and Francçoise M. Winnik |
| 220-227 | Reversible Lipidization Prolongs the Pharmacological Effect, Plasma Duration, and Liver Retention of Octreotide | Liyun Yuan, Jeff Wang and Wei-Chiang Shen |
| 228-234 | Altered Pharmacokinetics of Paclitaxel in Experimental Hepatic or Renal Failure | Mari Jiko, Ikuko Yano, Masahiro Okuda and Ken-ichi Inui |
| 235-244 | Pharmacokinetics of Substrate Uptake and Distribution in Murine Brain After Nasal Instillation | Candace L. Graff, Rong Zhao and Gary M. Pollack |
| 245-254 | A Randomly Coiled, High-Molecular-Weight Polypeptide Exhibits Increased Paracellular Diffusion in Vitro and in Situ Relative to the Highly Ordered α-Helix Conformer | Nazila Salamat-Miller, Montakarn Chittchang, Ashim K. Mitra and Thomas P. Johnston |
| 255-259 | Metformin Transport by Renal Basolateral Organic Cation Transporter hOCT2 | Naoko Kimura, Masahiro Okuda and Ken-ichi Inui |
| 260-269 | Estimation of the Three-Dimensional Pharmacophore of Ligands for Rat Multidrug-Resistance–Associated Protein 2 Using Ligand-Based Drug Design Techniques | Shuichi Hirono, Izumi Nakagome, Rie Imai, Kazuya Maeda and Hiroyuki Kusuhara, et al. |
| 270-275 | The Relation Between Granule Size, Granule Stickiness, and Torque in the High-Shear Granulation Process | A. M. Bouwman, M. J. Henstra, J. J. M. E. Hegge, Z. Zhang and A. Ingram, et al. |
| 276-284 | Preparation of Microparticles by Micromixers: Characterization of Oil/Water Process and Prediction of Particle Size | Kathrin Schalper, Stephan Harnisch, Rainer H. Müller and Gesine E. Hildebrand |
| 285-292 | Influence of Lipid Nanocapsules Composition on Their Aptness to Freeze-Drying | Claire Dulieu and Didier Bazile |
| 293-302 | Study of Pharmaceutical Solid Dispersions by Microthermal Analysis | Marc Galop |
| 303-309 | Raffinose Crystallization During Freeze-Drying and Its Impact on Recovery of Protein Activity | Koustuv Chatterjee, Evgenyi Y. Shalaev and Raj Suryanarayanan |
| 310-317 | Use of 2,2′-Azobis(2-Amidinopropane) Dihydrochloride as a Reagent Tool for Evaluation of Oxidative Stability of Drugs | Seema Betigeri, Ajit Thakur and Krishnaswamy Raghavan |
| 318-324 | Deliquescence in Binary Mixtures | Adnan K. Salameh and Lynne S. Taylor |
| 325-331 | Book Reviews |
| 332-333 | AAPS Update |
| 335-346 | Compartmental Modeling of Transdermal Iontophoretic Transport II: In Vivo Model Derivation and Application | Akhmad Kharis Nugroho, Oscar Della-Pasqua, Meindert Danhof and Joke A. Bouwstra |
| 347-355 | Intravenous Hydrophobic Drug Delivery: A Porous Particle Formulation of Paclitaxel (AI-850) | Julie A. Straub, Donald E. Chickering, Jonathan C. Lovely, Huimin Zhang and Bhavdeep Shah, et al. |
| 356-361 | A Novel, Lipid-Free Nanodispersion Formulation of Propofol and Its Characterization | Hongming Chen, Zhong Zhang, Örn Almarsson, Jean-Francois Marier and Dina Berkovitz, et al. |
| 362-372 | A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA | Lloyd B. Jeffs, Lorne R. Palmer, Ellen G. Ambegia, Cory Giesbrecht and Shannon Ewanick, et al. |
| 373-380 | Cross-linked Small Polyethylenimines: While Still Nontoxic, Deliver DNA Efficiently to Mammalian Cells in Vitro and in Vivo | Mini Thomas, Qing Ge, James J. Lu, Jianzhu Chen and Alexander Klibanov |
| 381-389 | A New Class of 5-Fluoro-2′-deoxyuridine Prodrugs Conjugated with a Tumor-Homing Cyclic Peptide CNGRC by Ester Linkers: Synthesis, Reactivity, and Tumor-Cell–Selective Cytotoxicity | Zhouen Zhang, Hiroshi Hatta, Kazuhito Tanabe and Sei-ichi Nishimot o |
| 390-396 | Bis(carbamoyloxymethyl) Esters of 2′,3′-Dideoxyuridine 5′-monophosphate (ddUMP) as Potential ddUMP Prodrugs | Saeed R. Khan, Srinivas K. Kumar and David Farquhar |
| 397-404 | Significant Intestinal Excretion, One Source of Variability in Pharmacokinetics of COL-3, a Chemically Modified Tetracycline | Jing Li, Shufeng Zhou, Hung Huynh and Eli Chan |
| 405-412 | Acute Changes in Muscle Blood Flow and Concomitant Muscle Damage after an Intramuscular Administration | Pierre Jean Ferré, Eckart Thein, Isabelle Raymond-Letron, Pierre-Louis Toutain and Hervé Pierre Lefebvre |
| 413-418 | Relationship Between Loperamide-Induced Sedative Effect and Digoxin Pharmacokinetics in Healthy Japanese Subjects | Michiya Kobayashi, Hiroshi Saitoh, Michiko Yamaguchi, Takeshi Saito and Hiroyoshi Fujita, et al. |
| 419-426 | Pharmacokinetic and Tissue Distribution Mechanism of Mouse Recombinant Heat Shock Protein 70 in Mice | Seiji Takemoto, Makiya Nishikawa and Yoshinobu Takakura |
| 427-439 | Formulation and Evaluation of Aerosolized Celecoxib for the Treatment of Lung Cancer | Alfred Haynes, Madhu Sudhan Shaik, Abhijit Chatterjee and M. Singh |
| 440-448 | Phase Behavior of Amorphous Molecular Dispersions II: Role of Hydrogen Bonding in Solid Solubility and Phase Separation Kinetics | Madhav Vasanthavada, Wei-Qin (Tony) Tong, Yatindra Joshi and M. Serpil Kislalioglu |
| 449-457 | Isolated Rafts from Adriamycin-Resistant P388 Cells Contain Functional ATPases and Provide an Easy Test System for P-glycoprotein–Related Activities | Karsten Bucher, Camille A. Besse, Sarah W. Kamau, Heidi Wunderli-Allenspach and Stefanie D. Krämer |
| 458-464 | Characterization of Polarized Expression of Point- or Deletion-Mutated Human BCRP/ABCG2 in LLC-PK1 Cells | Tappei Takada, Hiroshi Suzuki and Yuichi Sugiyama |
| 465-475 | Interaction of the Macrolide Antibiotic Azithromycin with Lipid Bilayers: Effect on Membrane Organization, Fluidity, and Permeability | A. Berquand, N. Fa, Y. F. Dufrêne and M.-P. Mingeot-Leclercq |
| 476-489 | Novel Film Modifiers to Alter the Physical Properties of Composite Ethylcellulose Films | Lai Wah Chan, Kang Teng Ong and Paul Wan Sia Heng |
| 490-495 | Comparative Investigation by Two Analytical Approaches of Enthalpy Relaxation for Glassy Glucose, Sucrose, Maltose, and Trehalose | Kiyoshi Kawai, Tomoaki Hagiwara, Rikuo Takai and Toru Suzuki |
| 496-497 | AAPS Update |
| 499-511 | Method Validation and Measurement of Biomarkers in Nonclinical and Clinical Samples in Drug Development: A Conference Report | Jean W. Lee, Russ S. Weiner, Jeff M. Sailstad, Ronald R. Bowsher and Dean W. Knuth, et al. |
| 512-517 | In Vitro and Pharmacophore-Based Discovery of Novel hPEPT1 Inhibitors | Sean Ekins, Jeffrey S. Johnston, Praveen Bahadduri, Vanessa M. D’Souza and Abhijit Ray, et al. |
| 518-522 | Micrometer-Scale Particle Sizing by Laser Diffraction: Critical Impact of the Imaginary Component of Refractive Index | Alice Beekman, Daxian Shan, Alana Ali, Weiguo Dai and Stephen Ward-Smith, et al. |
| 523-531 | Data Supplementation: A Pharmacokinetic/Pharmacodynamic Knowledge Creation Approach for Characterizing an Unexplored Region of the Response Surface | Ene I. Ette, Hui-May Chu and Christopher J. Godfrey |
| 532-540 | A Population Pharmacokinetic Model for Montelukast Disposition in Adults and Children | Rohini Ramakrishnan, Elizabeth Migoya and Barbara Knorr |
| 541-549 | Covariate Detection in Population Pharmacokinetics Using Partially Linear Mixed Effects Models | Peter L. Bonate |
| 550-555 | Transdermal Delivery of Human Growth Hormone Through RF-Microchannels | Galit Levin, Amikam Gershonowitz, Hagit Sacks, Meir Stern and Amir Sherman, et al. |
| 556-562 | Nipecotic Acid: Systemic Availability and Brain Delivery After Nasal Administration of Nipecotic Acid and n-Butyl Nipecotate to Rats | Hongna Wang, Anwar A. Hussain and Peter J. Wedlund |
| 563-572 | Local Delivery of Vancomycin for the Prophylaxis of Prosthetic Device-Related Infections | Dakshina M. Chilukuri and Jaymin C. Shah |
| 573-583 | Lyophilized Paclitaxel Magnetoliposomes as a Potential Drug Delivery System for Breast Carcinoma via Parenteral Administration: In Vitro and in Vivo Studies | J. Q. Zhang, Z. R. Zhang, H. Yang, Q. Y. Tan and S. R. Qin, et al. |
| 584-595 | Development and Characterization of Bioadhesive Vaginal Films of Sodium Polystyrene Sulfonate (PSS), a Novel Contraceptive Antimicrobial Agent | Sanjay Garg, Kavita Vermani, Alka Garg, Robert A. Anderson and William B. Rencher, et al. |
| 596-602 | Pharmacokinetics and Tissue Retention of (Gd-DTPA)-Cystamine Copolymers, a Biodegradable Macromolecular Magnetic Resonance Imaging Contrast Agent | Xinghe Wang, Yi Feng, Tianyi Ke, Matthias Schabel and Zheng-Rong Lu |
| 603-612 | Pharmacodynamic Assessment of the Benztropine Analogues AHN-1055 and AHN-2005 Using Intracerebral Microdialysis to Evaluate Brain Dopamine Levels and Pharmacokinetic/Pharmacodynamic Modeling | Sangeeta Raje, Jennifer Cornish, Amy H. Newman, Jianjing Cao and Jonathan L. Katz, et al. |
| 613-618 | Lack of Improvement of Oral Absorption of ME3277 by Prodrug Formation Is Ascribed to the Intestinal Efflux Mediated by Breast Cancer Resistant Protein (BCRP/ABCG2) | Chihiro Kondo, Reiko Onuki, Hiroyuki Kusuhara, Hiroshi Suzuki and Michiko Suzuki, et al. |
| 619-627 | Differential Contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in Vivo Renal Uptake of Uremic Toxins in Rats | Tsuneo Deguchi, Yousuke Kouno, Tetsuya Terasaki, Akira Takadate and Masaki Otagiri |
| 628-635 | Investigation of Solubility and Dissolution of a Free Base and Two Different Salt Forms as a Function of pH | Shoufeng Li, SuiMing Wong, Sundeep Sethia, Hassan Almoazen and Yatindra M. Joshi, et al. |
| 636-646 | A Natural Compound (Ginsenoside Re) Isolated from Panax ginseng as a Novel Angiogenic Agent for Tissue Regeneration | Ya-Chun Huang, Chiung-Tong Chen, Sung-Ching Chen, Po-Hong Lai and Huang-Chien Liang, et al. |
| 647-660 | Molecular Cloning and Functional Analyses of OAT1 and OAT3 from Cynomolgus Monkey Kidney | Harunobu Tahara, Masayuki Shono, Hiroyuki Kusuhara, Hajime Kinoshita and Eiichi Fuse, et al. |
| 661-666 | Treatment of Hyperbilirubinemia in Eisai Hyperbilirubinemic Rat by Transfecting Human MRP2/ABCC2 Gene | Masakazu Hirouchi, Hiroshi Suzuki and Yuichi Sugiyama |
| 667-675 | High-Performance Frontal Analysis of the Binding of Thyroxine Enantiomers to Human Serum Albumin Binding of Thyroxine Enantiomers to Human Serum Albumin Kimura | Tomoko Kimura, Keiko Nakanishi, Terumichi Nakagawa, Akimasa Shibukawa and Katsumi Matsuzaki |
| 676-684 | Development of Novel Nonaqueous Ethylcellulose Gel Matrices: Rheological and Mechanical Characterization | P. W. S. Heng, L. W. Chan and K. T. Chow |
| 685-700 | Freeze-Drying Process Design by Manometric Temperature Measurement: Design of a Smart Freeze-Dryer | Xiaolin (Charlie) Tang, Steven L. Nail and Michael J. Pikal |
| 701-702 | AAPS Update |
| 703-709 | A Strategy to Identify Stable Membrane-Permeant Peptide Inhibitors of Myosin Light Chain Kinase | Siân-Eleri Owens, W. Vallen Graham, Dario Siccardi, Jerrold R. Turner and Randall J. Mrsny |
| 710-715 | P-Glycoprotein Induction and Tumor Cell-Kill Dynamics in Response to Differential Doxorubicin Dosing Strategies: A Theoretical Pharmacodynamic Model | Kenneth T. Luu and James A. Uchizono |
| 716-720 | Intracellular Delivery of Bak BH3 Peptide by Microbubble-Enhanced Ultrasound | Manabu Kinoshita and Kullervo Hynynen |
| 721-727 | Experimental and Computational Studies of Epithelial Transport of Mefenamic Acid Ester Prodrugs | Kamonthip Wiwattanawongsa, Vimon Tantishaiyakul, Luelak Lomlim, Yon Rojanasakul and Sirirat Pinsuwan, et al. |
| 728-735 | The Talinolol Double-Peak Phenomenon Is Likely Caused by Presystemic Processing After Uptake from Gut Lumen | Werner Weitschies, Annika Bernsdorf, Thomas Giessmann, Michael Zschiesche and Christiane Modess, et al. |
| 736-742 | PEGylation of Octreotide: I. Separation of Positional Isomers and Stability Against Acylation by Poly(D,L-lactide-co-glycolide) | Dong Hee Na and Patrick P. DeLuca |
| 743-749 | PEGylation of Octreotide: II. Effect of N-terminal Mono-PEGylation on Biological Activity and Pharmacokinetics | Dong Hee Na, Kang Choon Lee and Patrick P. DeLuca |
| 750-757 | Comparative Study of the Skin Penetration of Protein Transduction Domains and a Conjugated Peptide | Luciana B. Lopes, Colleen M. Brophy, Elizabeth Furnish, Charles R. Flynn and Olivia Sparks, et al. |
| 758-765 | Human Skin Permeation of Branched-Chain 3-O-Alkyl Ester and Carbonate Prodrugs of Naltrexone | Haranath K. Vaddi, Mohamed O. Hamad, Jianhong Chen, Stan L. Banks and Peter A. Crooks, et al. |
| 766-775 | Effect of Particle Size of Nanospheres and Microspheres on the Cellular-Association and Cytotoxicity of Paclitaxel in 4T1 Cells | Sinjan De, Donald W. Miller and Dennis H. Robinson |
| 776-783 | Regional Radiochemotherapy Using In Situ Hydrogel | Ali Azhdarinia, David J. Yang, Dong-Fang Yu, Richard Mendez and Changsok Oh, et al. |
| 784-788 | The Influence of Water Content of Triglyceride Oils on the Solubility of Steroids | Laura M. Land, Ping Li and Paul Michael Bummer |
| 789-796 | Non-native Intermediate Conformational States of Human Growth Hormone in the Presence of Organic Solvents | Muppalla Sukumar, Sacha M. Storms and Michael R. De Felippis |
| 797-805 | Comparison of Molecular Mobility in the Glassy State Between Amorphous Indomethacin and Salicin Based on Spin-Lattice Relaxation Times | Katsuhiko Masuda, Sachio Tabata, Yasuyuki Sakata, Tetsuo Hayase and Etsuo Yonemochi, et al. |
| 806-815 | Interactions of Poly(vinylpyrrolidone) with Ibuprofen and Naproxen: Experimental and Modeling Studies | Svetla Bogdanova, Ilza Pajeva, Petya Nikolova, Ivanka Tsakovska and Bernd Müller |
| 816-825 | Surface Energy and Interparticle Force Correlation in Model pMDI Formulations | Daniela Traini, Philippe Rogueda, Paul Young and Robert Price |
| 826-835 | Controlled Release of Dexamethasone from Microcapsules Produced by Polyelectrolyte Layer-by-Layer Nanoassembly | Nikhil Pargaonkar, Yuri M. Lvov, Ning Li, Jan H. Steenekamp and Melgardt M. de Villiers |
| 836-837 | AAPS Update |
| 839-841 | Reviewers for Pharmaceutical Research for the Period November 1, 2003, to December 31, 2004 |
| 842-846 | Multidrug Resistance—Associated Protein 1 Functions as an Efflux Pump of Xenobiotics in the Skin | Qing Li, Yukio Kato, Yoshimichi Sai, Teruko Imai and Akira Tsuji |
| 847-851 | Development of a Transgenic Mouse Model Immune Tolerant for Human Interferon Beta | Suzanne Hermeling, Wim Jiskoot, Daan Crommelin, Claus Bornæs and Huub Schellekens |
| 852-857 | Vascular EndotheliumSelective Gene Induction by Tie2 Promoter/Enhancer in the Brain and Retina of a Transgenic Rat | Sumio Ohtsuki, Naoko Kamiya, Satoko Hori and Tetsuya Terasaki |
| 858-866 | Interactions of Stevioside and Steviol with Renal Organic Anion Transporters in S2 Cells and Mouse Renal Cortical Slices | Chutima Srimaroeng, Promsuk Jutabha, John B. Pritchard, Hitoshi Endou and Varanuj Chatsudthipong |
| 867-874 | Formulating Paclitaxel in Nanoparticles Alters Its Disposition | Teng Kuang Yeh, Ze Lu, M. Guillaume Wientjes and Jessie L.-S. Au |
| 875-882 | log P Estimation of 1,2-Dithiole-3-thiones and 1,2-Dithiole-3-ones: A Comparison of Experimental and Calculative Approaches | Sylvain Gargadennec, Gwenola Burgot, Jean-Louis Burgot, Raimund Mannhold and Roelof F. Rekker |
| 883-891 | Tissue-Specific Characteristics of in Vivo Electric Gene: Transfer by Tissue and Intravenous Injection of Plasmid DNA | Oranuch Thanaketpaisarn, Makiya Nishikawa, Fumiyoshi Yamashita and Mitsuru Hashida |
| 892-901 | Pharmacokinetics and Modeling of Quercetin and Metabolites | Xiao Chen, Ophelia Q. P. Yin, Zhong Zuo and Moses S. S. Chow |
| 902-914 | St. John’s Wort Modulates the Toxicities and Pharmacokinetics of CPT-11 (Irinotecan) in Rats | Zeping Hu, Xiaoxia Yang, Paul Chi-Liu Ho, Eli Chan and Sui Yung Chan, et al. |
| 915-922 | Trastuzumab and Liposomal Doxorubicin in the Treatment of MCF-7 Xenograft Tumor-Bearing Mice: Combination Does Not Affect Drug Serum Levels | Dawn N. Waterhouse, Tetyana Denyssevych, Norma Hudon, Stephen Chia and Karen A. Gelmon, et al. |
| 923-932 | The Role of Capsule on the Performance of a Dry Powder Inhaler Using Computational and Experimental Analyses | Matthew S. Coates, David F. Fletcher, Hak-Kim Chan and Judy A. Raper |
| 933-939 | Enhanced Intracellular Uptake of Sterically Stabilized Liposomal Doxorubicin in Vitro Resulting in Improved Antitumor Activity in Vivo | Xiao-Bing Xiong, Yue Huang, Wan-liang Lu, Hua Zhang and Xuan Zhang, et al. |
| 940-950 | Insulin-like Growth Factor I—Releasing Alginate-Tricalciumphosphate Composites for Bone Regeneration | Vera Luginbuehl, Esther Wenk, Annette Koch, Bruno Gander and Hans P. Merkle, et al. |
| 951-961 | Tumor-Targeted Gene Delivery Using Poly(Ethylene Glycol)-Modified Gelatin Nanoparticles: In Vitro and in Vivo Studies | Goldie Kaul and Mansoor Amiji |
| 962-971 | Cyclodextrin-Mediated Drug Release from Liposomes Dispersed Within a Bioadhesive Gel | Laïla Boulmedarat, Géraldine Piel, Amélie Bochot, Sylviane Lesieur and Luc Delattre, et al. |
| 972-980 | N4,N9-Dioleoyl Spermine Is a Novel Nonviral Lipopolyamine Vector for Plasmid DNA Formulation | Osama A. A. Ahmed, Noppadon Adjimatera, Charareh Pourzand and Ian S. Blagbrough |
| 981-989 | In Vitro/in Vivo Correlation of Transdermal Naltrexone Prodrugs in Hairless Guinea Pigs | Satyanarayana Valiveti, Kalpana S. Paudel, Dana C. Hammell, Mohamed O. Hamad and Jianhong Chen, et al. |
| 990-998 | Spray-Dried Amorphous Solid Dispersions of Simvastatin, a Low Tg Drug: In Vitro and in Vivo Evaluations | Anshuman A. Ambike, K. R. Mahadik and Anant Paradkar |
| 999-1006 | Solid-State Fluorescence Studies of Some Polymorphs of Diflunisal* | Harry G. Brittain, Bruce J. Elder, Paul K. Isbester and Allen H. Salerno |
| 1007 | Chitosan Nanoparticles as New Ocular Drug Delivery Systems: In Vitro Stability, in Vivo Fate, and Cellular Toxicity | Angela M. de Campos, Yolanda Diebold, Edison L. S. Carbalho, Alejandro Sánchez and María José Alonso |
| 1008-1009 | AAPS Update
|
| 1011-1037 | Enhanced Prospects for Drug Delivery and Brain Targeting by the Choroid Plexus–CSF Route | Conrad E. Johanson, John A. Duncan, Edward G. Stopa and Andrew Baird |
| 1038-1049 | Disease System Analysis: Basic Disease Progression Models in Degenerative Disease | Teun M. Post, Jan I. Freijer, Joost DeJongh and Meindert Danhof |
| 1050-1058 | Role of Intestinal First-Pass Metabolism of Baicalein in its Absorption Process | Li Zhang, Ge Lin, Qi Chang and Zhong Zuo |
| 1059-1068 | Optimization and Applications of CDAP Labeling for the Assignment of Cysteines | Gary D. Pipes, Andrew A. Kosky, Jeffrey Abel, Yu Zhang and Michael J. Treuheit, et al. |
| 1069-1078 | Nontoxic Suramin Treatments Enhance Docetaxel Activity in Chemotherapy-Pretreated Non-Small Cell Lung Xenograft Tumors | Ze Lu, Trini S.-S. Wientjes and Jessie L.-S. Au |
| 1079-1087 | 3D-Resolved Investigation of the pH Gradient in Artificial Skin Constructs by Means of Fluorescence Lifetime Imaging | Raluca Niesner, Bülent Peker, Peter Schlüsche, Karl-Heinz Gericke and Christine Hoffmann, et al. |
| 1088-1100 | Pharmacokinetic–Pharmacodynamic–Efficacy Analysis of Efalizumab in Patients with Moderate to Severe Psoriasis | Chee M. Ng, Amita Joshi, Russell L. Dedrick, Marvin R. Garovoy and Robert J. Bauer |
| 1101-1109 | Interconversion Pharmacokinetics of Simvastatin and its Hydroxy Acid in Dogs: Effects of Gemfibrozil | Thomayant Prueksaritanont, Yue Qiu, Lillian Mu, Kimberly Michel and Janice Brunner, et al. |
| 1110-1116 | Sustained Vascular Endothelial Growth Factor Delivery Enhances Angiogenesis and Perfusion in Ischemic Hind Limb | Qinghua Sun, Ruth R. Chen, Yuechun Shen, David J. Mooney and Sanjay Rajagopalan, et al. |
| 1117-1120 | Targeting of the Antivascular Drug Combretastatin to Irradiated Tumors Results in Tumor Growth Delay | Christopher B. Pattillo, Farid Sari-Sarraf, Ramakrishna Nallamothu, Bob M. Moore and George C. Wood, et al. |
| 1121-1128 | Localization and Differential Activity of P-glycoprotein in the Bovine Olfactory and Nasal Respiratory Mucosae | Karunya K. Kandimalla and Maureen D. Donovan |
| 1129-1141 | pH-Sensitive Polymer Blends Used as Coating Materials to Control Drug Release from Spherical Beads: Elucidation of the Underlying Mass Transport Mechanisms | Florence Lecomte, Juergen Siepmann, Mathias Walther, Ross J. MacRae and Roland Bodmeier |
| 1142-1148 | Molecular Mobility in Raffinose in the Crystalline Pentahydrate Form and in the Amorphous Anhydrous Form | Joaquim J. Moura Ramos, Susana S. Pinto and Hermínio P. Diogo |
| 1149-1157 | A Quantitative Model to Evaluate Solubility Relationship of Polymorphs from Their Thermal Properties | Chen Mao, Rodolfo Pinal and Kenneth R. Morris |
| 1158-1166 | Characterization of Drug Particle Surface Energetics and Young’s Modulus by Atomic Force Microscopy and Inverse Gas Chromatography | Michael Davies, Anne Brindley, Xinyong Chen, Maria Marlow and Stephen W. Doughty, et al. |
| 1167-1175 | The Effect of Stabilizers and Denaturants on the Cold Denaturation Temperatures of Proteins and Implications for Freeze-Drying | Xiaolin (Charlie) Tang and Michael J. Pikal |
| 1176-1185 | Measurement of the Kinetics of Protein Unfolding in Viscous Systems and Implications for Protein Stability in Freeze-Drying | Xiaolin (Charlie) Tang and Michael J. Pikal |
| 1186-1194 | Interaction of Polysorbate 80 with Erythropoietin: A Case Study in Protein–Surfactant Interactions | Annabelle P. Villalobos, Srinivas R. Gunturi and George A. Heavner |
| 1195-1202 | Identifying and Mapping Surface Amorphous Domains | Stuart Ward, Mark Perkins, Jianxin Zhang, Clive J. Roberts and Claire E. Madden, et al. |
| 1203-1204 | AAPS UpdateAAPS—Your Formula for Success |
| 1425-1431 | Bioanalytical Method Validation for Macromolecules in Support of Pharmacokinetic Studies | JoMarie Smolec, Binodh DeSilva, Wendell Smith, Russell Weiner and Marian Kelly, et al. |
| 1432-1437 | Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling—A New Classification of Biomarkers | Meindert Danhof, Gunnar Alvan, Svein G. Dahl, Jochen Kuhlmann and Gilles Paintaud |
| 1438-1444 | Supramolecular Behavior of the Amphiphilic Drug (2R)-2-Ethylchromane-2-Carboxylic Acid Arginine Salt (a Novel PPARα/γ Dual Agonist) | Andrey Peresypkin, Gloria Kwei, Martha Ellison, Kari Lynn and Dina Zhang, et al. |
| 1445-1453 | Influence of Air Flow on the Performance of a Dry Powder Inhaler Using Computational and Experimental Analyses | Matthew S. Coates, Hak-Kim Chan, David F. Fletcher and Judy A. Raper |
| 1454-1460 | Prediction of pKa for Neutral and Basic Drugs Based on Radial Basis Function Neural Networks and the Heuristic Method | Feng Luan, Weiping Ma, Haixia Zhang, Xiaoyun Zhang and Mancang Liu, et al. |
| 1461-1470 | Novel Long-Acting Crystal Formulation of Human Growth Hormone | Chandrika Govardhan, Nazer Khalaf, Chu W. Jung, Ben Simeone and Amy Higbie, et al. |
| 1471-1479 | 99mTc-EC-Guanine: Synthesis, Biodistribution, and Tumor Imaging in Animals | David J. Yang, Kaoru Ozaki, Chang-Sok Oh, Ali Azhdarinia and Thomas Yang, et al. |
| 1480-1488 | Synthesis and in Vitro Evaluation of a Novel Chitosan–Glutathione Conjugate | Krum Kafedjiiski, Florian Föger, Martin Werle and Andreas Bernkop-Schnürch |
| 1489-1498 | Comparison of the Pharmacokinetics of Oxycodone and Noroxycodone in Male Dark Agouti and Sprague–Dawley Rats: Influence of Streptozotocin-Induced Diabetes | Lillian Huang, Stephen R. Edwards and Maree T. Smith |
| 1499-1509 | Metabolic and Pharmacological Properties of Rutin, a Dietary Quercetin Glycoside, for Treatment of Inflammatory Bowel Disease | Heejung Kim, Hyesik Kong, Boim Choi, Youngwook Yang and Youngmi Kim, et al. |
| 1510-1518 | Floxuridine Amino Acid Ester Prodrugs: Enhancing Caco-2 Permeability and Resistance to Glycosidic Bond Metabolism | Christopher P. Landowski, Xueqin Song, Philip L. Lorenzi, John M. Hilfinger and Gordon L. Amidon |
| 1519-1524 | The Influence of Iontophoresis on Acyclovir Transport and Accumulation in Rabbit Ear Skin | Cristina Padula, Francesca Sartori, Fabio Marra and Patrizia Santi |
| 1525-1529 | Transport of Fentanyl Through Pig Buccal and Esophageal Epithelia in Vitro. Influence of Concentration and Vehicle pH | Isabel Diaz del Consuelo, Françoise Falson, Richard H. Guy and Yves Jacques |
| 1530-1536 | Skin Localization of Cow’s Milk Proteins Delivered by a New Ready-to-Use Atopy Patch Test | D. Soury, G. Barratt, S. Ah-Leung, P. Legrand and H. Chacun, et al. |
| 1537-1543 | Impact of the Amount of Excess Solids on Apparent Solubility | Kohsaku Kawakami, Kyoko Miyoshi and Yasuo Ida |
| 1544-1555 | Molecular Properties of Ibuprofen and Its Solid Dispersions with Eudragit RL100 Studied by Solid-State Nuclear Magnetic Resonance | Marco Geppi, Salvatore Guccione, Giulia Mollica, Rosario Pignatello and Carlo A. Veracini |
| 1556-1557 | AAPS UpdateAAPS–YOUR FORMULA FOR SUCCESS! |
| 1559-1577 | Apical/Basolateral Surface Expression of Drug Transporters and its Role in Vectorial Drug Transport | Kousei Ito, Hiroshi Suzuki, Toshiharu Horie and Yuichi Sugiyama |
| 1578-1588 | Potential Role of Acyl-Coenzyme A:Cholesterol Transferase (ACAT) Inhibitors as Hypolipidemic and Antiatherosclerosis Drugs | Carlos Leon, John S. Hill and Kishor M. Wasan |
| 1589-1596 | Quasi-Equilibrium Pharmacokinetic Model for Drugs Exhibiting Target-Mediated Drug Disposition | Donald E. Mager and Wojciech Krzyzanski |
| 1597-1613 | VeloceGenomics: An Accelerated in Vivo Drug Discovery Approach to Rapidly Predict the Biologic, Drug-Like Activity of Compounds, Proteins, or Genes | Ruben Papoian, Andreas Scherer, Muriel Saulnier, Frank Staedtler and André Cordier, et al. |
| 1614-1626 | Uncertainty Analysis in Pharmacokinetics and Pharmacodynamics: Application to Naratriptan | Ivelina Gueorguieva, Ivan A. Nestorov, Leon Aarons and Malcolm Rowland |
| 1627-1633 | Changes in Immune Responses to Antigen Applied to Tape-Stripped Skin with CpG-Oligodeoxynucleotide in NC/Nga Mice | Joe Inoue, Satoshi Yotsumoto, Takatoshi Sakamoto, Seishi Tsuchiya and Yukihiko Aramaki |
| 1634-1641 | Suppression of Cell Proliferation by Inhibition of Estrone-3-Sulfate Transporter in Estrogen-Dependent Breast Cancer Cells | Takashi Nozawa, Masato Suzuki, Hikaru Yabuuchi, Masanori Irokawa and Akira Tsuji, et al. |
| 1642-1648 | Reaction of 5-Aminosalicylic Acid with Peroxyl Radicals: Protection and Recovery by Ascorbic Acid and Amino Acids | Camilo López-Alarcón, Claudia Rocco, Eduardo Lissi, Catalina Carrasco and J. Arturo Squella, et al. |
| 1649-1657 | The Thermodynamics of the Partitioning of Ionizing Molecules Between Aqueous Buffers and Phospholipid Membranes | Rupert P. Austin, Patrick Barton, Andrew M. Davis, Roger E. Fessey and Mark C. Wenlock |
| 1658-1666 | Pharmacokinetics of Dietary Phenethyl Isothiocyanate in Rats | Yan Ji, Yuhsin Kuo and Marilyn E. Morris |
| 1667-1677 | The Steady-State Michaelis–Menten Analysis of P-Glycoprotein Mediated Transport Through a Confluent Cell Monolayer Cannot Predict the Correct Michaelis Constant Km | Joe Bentz, Thuy Thanh Tran, Joseph W. Polli, Andrew Ayrton and Harma Ellens |
| 1678-1684 | Pharmacokinetic Differences between Pantoprazole Enantiomers in Rats | Zhiyong Xie, Yini Zhang, Haiyan Xu and Dafang Zhong |
| 1685-1691 | In Vivo Human MCP-1 Transfection in Porcine Arteries by Intravascular Electroporation | Randolph W. Seidler, Susanne Allgäuer, Susanne Ailinger, Andreas Sterner and Nagendu Dev, et al. |
| 1692-1699 | Airway Identification Within Planar Gamma Camera Images Using Computer Models of Lung Morphology | Jeffry D. Schroeter, John N. Pritchard, Dongming Hwang and Ted B. Martonen |
| 1700-1707 | Feasibility of Tissue Plasminogen Activator Formulated for Pulmonary Delivery | John S. Dunn, Rajiv Nayar, Jackie Campos, Brooks M. Hybertson and Yue Zhou, et al. |
| 1708-1715 | Isostatic Ultra-High-Pressure Effects on Supercooled Melts in Colloidal Triglyceride Dispersions | Christoph Blümer and Karsten Mäder |
| 1716-1726 | Mechanism of the Solution Oxidation of Rofecoxib Under Alkaline Conditions | Paul A. Harmon, Stephen Biffar, Steven M. Pitzenberger and Robert A. Reed |
| 1727-1734 | Stabilization and Improved in Vivo Performance of Amorphous Etoricoxib using Gelucire 50/13 | Shamkant L. Shimpi, Bhaskar Chauhan, K. R. Mahadik and Anant Paradkar |
| 1735-1746 | Stabilizing Peptide Fusion for Solving the Stability and Solubility Problems of Therapeutic Proteins | Eui Nam Lee, Young Mok Kim, Hye Ja Lee, Sang Woo Park and Han Young Jung, et al. |
| 1747-1756 | Stability, Dose Uniformity, and Palatability of Three Counterterrorism Drugs—Human Subject and Electronic Tongue Studies | Nakissa Sadrieh, James Brower, Lawrence Yu, William Doub and Arthur Straughn, et al. |
| 1757-1761 | EGFR mRNA is Upregulated, but Somatic Mutations of the Gene are Hardly Found in Renal Cell Carcinoma in Japanese Patients | Toshiyuki Sakaeda, Noboru Okamura, Akinobu Gotoh, Toshiro Shirakawa and Shuji Terao, et al. |
| 1762-1766 | Phenotyping and Genotyping Studies of Thiopurine S-Methyltransferase in Kazaks | Hong Wei, Shufeng Zhou, Chengrong Li, Jianping Zhang and Jueheng Wu, et al. |
| 1767-1768 | AAPS Update
|
| 1769-1782 | Pharmacokinetic–Pharmacodynamic Modeling of the Hydroxy Lerisetron Metabolite L6-OH in Rats: An Integrated Parent–Metabolite Model | Fátima Ortega, Antonio Quintana, Elena Suárez, John C. Lukas and Nerea Jauregizar, et al. |
| 1783-1792 | Modeling of Human Corticosteroid Binding Globulin. Use of Structure–Activity Relations in Soft Steroid Binding to Refine the Structure | Roy J. Little and C. G. Rodríguez |
| 1793-1804 | Membrane Binding Proteins are the Major Determinants for the Hepatocellular Transmembrane Flux of Long-Chain Fatty Acids Bound to Albumin | G. Rajaraman, M. S. Roberts, D. Hung, G. Q. Wang and F. J. Burczynski |
| 1805-1820 | Comparison of (−)-Epigallocatechin-3-Gallate Elicited Liver and Small Intestine Gene Expression Profiles Between C57BL/6J Mice and C57BL/6J/Nrf2 (−/−) Mice | Guoxiang Shen, Changjiang Xu, Rong Hu, Mohit R. Jain and Sujit Nair, et al. |
| 1821-1828 | Blood Compatibility of Cetyl Alcohol/Polysorbate-Based Nanoparticles | J. M. Koziara, J. J. Oh, W. S. Akers, S. P. Ferraris and R. J. Mumper |
| 1829-1836 | Modification of the P-Glycoprotein Dependent Pharmacokinetics of Digoxin in Rats by Human Recombinant Interferon-α | Makrem Ben Reguiga, Laurence Bonhomme-Faivre, Simone Orbach-Arbouys and Robert Farinotti |
| 1837-1853 | Human Multidrug Resistance Associated Protein 4 Confers Resistance to Camptothecins | Quan Tian, Jing Zhang, Theresa May Chin Tan, Eli Chan and Wei Duan, et al. |
| 1854-1862 | Region-Dependent Role of the Mucous/Glycocalyx Layers in Insulin Permeation Across Rat Small Intestinal Membrane | Yoshinobu Aoki, Mariko Morishita, Kazunori Asai, Bunshiro Akikusa and Shuji Hosoda, et al. |
| 1863-1870 | Bile Increases Intestinal Lymphatic Drug Transport in the Fasted Rat | Natalie L. Trevaskis, Christopher J. H. Porter and William N. Charman |
| 1871-1878 | The Effect of Formulation Variables and Breathing Patterns on the Site of Nasal Deposition in an Anatomically Correct Model | Yang Guo, Beth Laube and Richard Dalby |
| 1879-1886 | Insulin Containing Nanocomplexes Formed by Self-Assembly from Biodegradable Amine-Modified Poly(Vinyl Alcohol)-Graft-Poly(l-Lactide): Bioavailability and Nasal Tolerability in Rats | Michael Simon, Matthias Wittmar, Thomas Kissel and Thomas Linn |
| 1887-1897 | Solid Lipid Nanoparticles (SLN) and Oil-Loaded SLN Studied by Spectrofluorometry and Raman Spectroscopy | Katja Jores, Annekathrin Haberland, Siegfried Wartewig, Karsten Mäder and Wolfgang Mehnert |
| 1898-1905 | Tissue Distribution of Indinavir Administered as Solid Lipid Nanocapsule Formulation in mdr1a (+/+) and mdr1a (−/−) CF-1 Mice | Manuela Pereira de Oliveira, Emmanuel Garcion, Nicolas Venisse, Jean-Pierre Benoît and William Couet, et al. |
| 1906-1917 | Immunoliposomes Directed Toward VCAM-1 Interact Specifically with Activated Endothelial Cells—A Potential Tool for Specific Drug Delivery | Manuela Voinea, Ileana Manduteanu, Elena Dragomir, Monica Capraru and Maya Simionescu |
| 1918-1925 | Investigation of Iminosulfuranes as Novel Transdermal Penetration Enhancers: Enhancement Activity and Cytotoxicity | Yifan Song, Chunhong Xiao, Richard Mendelsohn, Tao Zheng and Lucjan Strekowski, et al. |
| 1926-1930 | Differences in Surfactant Lipids Collected from Pleural and Pulmonary Lining Fluids | Paul C. Mills, Yi Chen, Yvette C. Hills and Brian A. Hills |
| 1931-1941 | Displacement of Adsorbed Insulin by Tween 80 Monitored Using Total Internal Reflection Fluorescence and Ellipsometry | S. H. Mollmann, U. Elofsson, J. T. Bukrinsky and S. Frokjaer |
| 1942-1953 | Quantification of Crystallinity in Substantially Amorphous Materials by Synchrotron X-ray Powder Diffractometry | Cletus Nunes, Arumugam Mahendrasingam and Raj Suryanarayanan |
| 1954-1963 | Alteration of the Pharmacokinetics of COL-3, a Matrix Metalloproteinase Inhibitor, Due to Acute Gastrointestinal Toxicity of Doxorubicin | Jing Li, Shufeng Zhou, Hung Huynh, Wei Duan and Eli Chan |
| 1964-1969 | Study of Crystal Packing on the Solid-State Reactivity of Indomethacin with Density Functional Theory | Tonglei Li and Shaoxin Feng |
| 1970-1977 | Bitterness Suppression with Zinc Sulfate and Na-Cyclamate: A Model of Combined Peripheral and Central Neural Approaches to Flavor Modification | Russell S. J. Keast and Paul A. S. Breslin |
| 1978-1985 | Influence of the Active Pharmaceutical Ingredient Concentration on the Physical State of Mannitol—Implications in Freeze-Drying | Xiangmin Liao, Rajesh Krishnamurthy and Raj Suryanarayanan |
| 1986-1987 | AAPS Update
|
| 1989-1996 | Quantitative Structure–Activity Relationship and Quantitative Structure–Pharmacokinetics Relationship of 1,4-Dihydropyridines and Pyridines as Multidrug Resistance Modulators | Xiao-Fei Zhou, Qingxiang Shao, Robert A. Coburn and Marilyn E. Morris |
| 1997-2006 | Structural Characterization and Immunogenicity in Wild-Type and Immune Tolerant Mice of Degraded Recombinant Human Interferon Alpha2b | Suzanne Hermeling, Liliana Aranha, J. Mirjam A. Damen, Monique Slijper and Huub Schellekens, et al. |
| 2007-2015 | Activity and Expression of Various Isoforms of Uridine Diphosphate Glucuronosyltransferase are Differentially Regulated During Hepatic Regeneration in Rats | Hui Tian, Junhai Ou, Stephen C. Strom and Raman Venkataramanan |
| 2016-2022 | Pharmacokinetic Significance of Renal OAT3 (SLC22A8) for Anionic Drug Elimination in Patients with Mesangial Proliferative Glomerulonephritis | Yuji Sakurai, Hideyuki Motohashi, Ken Ogasawara, Tomohiro Terada and Satohiro Masuda, et al. |
| 2023-2034 | BCRP Transports Dipyridamole and is Inhibited by Calcium Channel Blockers | Yi Zhang, Anshul Gupta, Honggang Wang, Lin Zhou and R. Robert Vethanayagam, et al. |
| 2035-2044 | Pharmacokinetic and Pharmacodynamic Evaluations of the Zwitterionic Metabolite of a New Series of N-Substituted Soft Anticholinergics | Whei-Mei Wu, Peter Buchwald, Nobuhiro Mori, Fubao Ji and JiaXiang Wu, et al. |
| 2045-2050 | In Vitro Evaluation of Various Buccal Permeation Enhancing Systems for PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide) | Nina Langoth, Andreas Bernkop-Schnürch and Peter Kurka |
| 2051-2057 | Development of Stealth Liposome Formulation of 2′-Deoxyinosine as 5-Fluorouracil Modulator: In Vitro and In Vivo Study | Raphaelle Fanciullino, Sarah Giacometti, Claude Aubert, Frederic Fina and Pierre-Marie Martin, et al. |
| 2058-2068 | Uptake and Transport of PEG-Graft-Trimethyl-Chitosan Copolymer–Insulin Nanocomplexes by Epithelial Cells | Shirui Mao, Oliver Germershaus, Dagmar Fischer, Thomas Linn and Robert Schnepf, et al. |
| 2069-2078 | Effect of Charge and Molecular Weight on Transdermal Peptide Delivery by Iontophoresis | Nada Abla, Aarti Naik, Richard H. Guy and Yogeshvar N. Kalia |
| 2079-2090 | Self-Assembled Biodegradable Nanoparticles Developed by Direct Dialysis for the Delivery of Paclitaxel | Jingwei Xie and Chi-Hwa Wang |
| 2091-2098 | Sequence-Specific Suppression of mdr1a/1b Expression in Mice via RNA Interference | Yumi Matsui, Naoki Kobayashi, Makiya Nishikawa and Yoshinobu Takakura |
| 2099-2106 | Tat-Conjugated PAMAM Dendrimers as Delivery Agents for Antisense and siRNA Oligonucleotides | Hyunmin Kang, Robert DeLong, Michael H. Fisher and Rudolph L. Juliano |
| 2107-2114 | Poly(Ethylene Oxide)-Modified Poly(β-Amino Ester) Nanoparticles as a pH-Sensitive System for Tumor-Targeted Delivery of Hydrophobic Drugs: Part 2. In Vivo Distribution and Tumor Localization Studies | Dinesh Shenoy, Steven Little, Robert Langer and Mansoor Amiji |
| 2115-2120 | ATP-Loaded Liposomes Effectively Protect the Myocardium in Rabbits with an Acute Experimental Myocardial Infarction | Daya D. Verma, William C. Hartner, Tatayana S. Levchenko, Eugene A. Bernstein and Vladimir P. Torchilin |
| 2121-2133 | The Role of Molecular Structure in the Crystal Polymorphism of Local Anesthetic Drugs: Crystal Polymorphism of Local Anesthetic Drugs, Part X | Andrea C. Schmidt |
| 2134-2140 | Viscoelastic Properties of Carbopol 940 Gels and Their Relationships to Piroxicam Diffusion Coefficients in Gel Bases | Rathapon A-sasutjarit, Anuvat Sirivat and Panida Vayumhasuwan |
| 2141-2151 | The Effects of Food on the Dissolution of Poorly Soluble Drugs in Human and in Model Small Intestinal Fluids | Eva M. Persson, Ann-Sofie Gustafsson, Anders S. Carlsson, Ralf G. Nilsson and Lars Knutson, et al. |
| 2152-2162 | Comparison of Diafiltration and Tangential Flow Filtration for Purification of Nanoparticle Suspensions | Gautam Dalwadi, Heather A. E. Benson and Yan Chen |
| 2163-2173 | Cubosome Dispersions as Delivery Systems for Percutaneous Administration of Indomethacin | Elisabetta Esposito, Rita Cortesi, Markus Drechsler, Lydia Paccamiccio and Paolo Mariani, et al. |
| 2174-2175 | AAPS Update
| 2176-2179 | Author Index to Volume 22 (2005) |
| 2180-2184 | Subject Index to Volume 22 |
|
| 227-242 | Facilitating Physiologic Self-Regeneration: A Step Beyond Islet Cell Replacement | Pleunie P. M. Rood, Rita Bottino, A. N. Balamurugan, Yong Fan and David K. C. Cooper, et al. |
| 243-255 | Advances in the Use of Tocols as Drug Delivery Vehicles | Panayiotis P. Constantinides, Jihong Han and Stanley S. Davis |
| 256-261 | Analysis of Dissolution Data Using Modified Versions of Noyes–Whitney Equation and the Weibull Function | Aristides Dokoumetzidis, Vasiliki Papadopoulou and Panos Macheras |
| 262-269 | Strong Mucosal and Systemic Immunities Induced by Nasal Immunization with Anthrax Protective Antigen Protein Incorporated in Liposome–Protamine–DNA Particles | Brian R. Sloat and Zhengrong Cui |
| 270-279 | Expression and Transport Functionality of FcRn within Rat Alveolar Epithelium: A Study in Primary Cell Culture and in the Isolated Perfused Lung | Masahiro Sakagami, Yadollah Omidi, Lee Campbell, Lana E. Kandalaft and Christopher J. Morris, et al. |
| 280-290 | Transport Kinetics of Iron Chelators and Their Chelates in Caco-2 Cells | Xi-Ping Huang, M. Spino and J. J. Thiessen |
| 291-302 | Protein Kinase C Family Members as a Target for Regulation of Blood–Brain Barrier Na,K,2Cl-Cotransporter During In Vitro Stroke Conditions and Nicotine Exposure | Tianzhi Yang, Karen E. Roder, G. Jayarama Bhat, Thomas J. Thekkumkara and Thomas J. Abbruscato |
| 303-311 | Pharmacologic and Pharmacokinetic Assessment of Anti-TGFβ2 Aptamers in Rabbit Plasma and Aqueous Humor | Thomas G. McCauley, Jeffrey C. Kurz, Patricia G. Merlino, Scott D. Lewis and Madaline Gilbert, et al. |
| 312-328 | Fit-for-Purpose Method Development and Validation for Successful Biomarker Measurement | Jean W. Lee, Viswanath Devanarayan, Yu Chen Barrett, Russell Weiner and John Allinson, et al. |
| 329-335 | Kinetic Analysis on the Skin Disposition of Cytotoxicity as an Index of Skin Irritation Produced by Cetylpyridinium Chloride: Comparison of In Vitro Data using a Three-Dimensional Cultured Human Skin Model with In Vivo Results in Hairless Mice | Satoshi Kano and Kenji Sugibayashi |
| 336-349 | Prediction of Anticancer Drug Potency from Expression of Genes Involved in Growth Factor Signaling | Zunyan Dai, Catalin Barbacioru, Ying Huang and Wolfgang Sadée |
| 350-359 | Impact of Extracellular Protein Binding on Passive and Active Drug Transport Across Caco-2 Cells | Sibylle Neuhoff, Per Artursson, Ismael Zamora and Anna-Lena Ungell |
| 360-366 | Oleic Acid as Optimizer of the Skin Delivery of 5-Aminolevulinic Acid in Photodynamic Therapy | Maria Bernadete Riemma Pierre, Eduardo Ricci, Antonio Cláudio Tedesco and Maria Vitória Lopes Badra Bentley |
| 367-377 | Specific Delivery of Corroles to Cells via Noncovalent Conjugates with Viral Proteins | Hasmik Agadjanian, Jeremy J. Weaver, Atif Mahammed, Altan Rentsendorj and Sam Bass, et al. |
| 378-383 | The Systemic Absorption of Etoposide after Intravaginal Administration in Patients with Cervical Intraepithelial Lesions Associated with Human Papillomavirus Infection | P. García-López, M. Coll, E. Cervera, L. Reyes-Vermot and M. A. Torres, et al. |
| 384-391 | Novel Mucosal Insulin Delivery Systems Based on Fusogenic Liposomes | Takahiro Goto, Mariko Morishita, Ken Nishimura, Mahito Nakanishi and Atsushi Kato, et al. |
| 392-400 | The Mode of Promoting Activity of O-Ethylmenthol as a Transdermal Absorption Enhancer | Yasuko Obata, Yoshimichi Maruyama and Kozo Takayama |
| 401-407 | Determination of the Surface Free Energy of Crystalline and Amorphous Lactose by Atomic Force Microscopy Adhesion Measurement | Jianxin Zhang, Stephen Ebbens, Xinyong Chen, Zheng Jin and Shen Luk, et al. |
| 408-421 | Investigation of Wetting Behavior of Nonaqueous Ethylcellulose Gel Matrices Using Dynamic Contact Angle | L. W. Chan, K. T. Chow and P. W. S. Heng |
| 422-428 | Probing Beta Relaxation in Pharmaceutically Relevant Glasses by Using DSC | Sergey Vyazovkin and Ion Dranca |
| 429-437 | Dense Gas Processing of Micron-Sized Drug Formulations Incorporating Hydroxypropylated and Methylated Beta-Cyclodextrin | Raffaella Mammucari, Fariba Dehghani and Neil R. Foster |
| 438-444 | Report on the PQRI Impurity Characterization and Quantification Best Practices Survey | P. Faustino, C. C. Chan, J. Carrano, M. Gosnell and Z. Q. Gu, et al. |
| 445-446 | AAPS Update
|
| 447-459 | The Nuclear Pore Complex: The Gateway to Successful Nonviral Gene Delivery | Marieke A. E. M. van der Aa, Enrico Mastrobattista, Ronald S. Oosting, Wim E. Hennink and Gerben A. Koning, et al. |
| 460-474 | Methods to Assess in Vitro Drug Release from Injectable Polymeric Particulate Systems | Susan S. D'Souza and Patrick P. DeLuca |
| 475-482 | Gene Expression Profiles in Mouse Lung Tissue after Administration of Two Cationic Polymers Used for Nonviral Gene Delivery | Karin Regnström, Eva G. E. Ragnarsson, Mårten Fryknäs, Magnus Köping-Höggård and Per Artursson |
| 483-492 | Development of a QSAR Model for Binding of Tripeptides and Tripeptidomimetics to the Human Intestinal Di-/Tripeptide Transporter hPEPT1 | Rikke Andersen, Flemming Steen Jørgensen, Lars Olsen, Jon Våbenø and Karina Thorn, et al. |
| 493-505 | Mechanistic Study of the Cellular Interplay of Transport and Metabolism Using the Synthetic Modeling Method | Yu Liu and C. Anthony Hunt |
| 506-512 | Effects of Acid and Lactone Forms of Eight HMG-CoA Reductase Inhibitors on CYP-Mediated Metabolism and MDR1-Mediated Transport | Toshiyuki Sakaeda, Hideki Fujino, Chiho Komoto, Mikio Kakumoto and Jiang-shu Jin, et al. |
| 513-520 | Characterization of Human OATP2B1 (SLCO2B1) Gene Promoter Regulation | Tomoji Maeda, Masamichi Hirayama, Ryunosuke Higashi, Masanobu Sato and Ikumi Tamai |
| 521-532 | A Mechanism-Based Integrated Pharmacokinetic Enzyme Model Describing the Time Course and Magnitude of Phenobarbital-Mediated Enzyme Induction in the Rat | Mats O. Magnusson, Mats O. Karlsson and Rikard Sandström |
| 533-539 | Determination of a Human Hepatic Microsomal Scaling Factor for Predicting in Vivo Drug Clearance | Nancy Hakooz, Kiyomi Ito, Helen Rawden, Helen Gill and Lynn Lemmers, et al. |
| 540-548 | Voltage Dependence of Transepithelial Guanidine Permeation Across Caco-2 Epithelia Allows Determination of the Paracellular Flux Component | Georgina Carr, Iain S. Haslam and Nicholas L. Simmons |
| 549-556 | Efficacy and Mechanism of Action of Chitosan Nanocapsules for Oral Peptide Delivery | C. Prego, M. Fabre, D. Torres and M. J. Alonso |
| 557-564 | Magnetically Responsive Polymeric Microparticles for Oral Delivery of Protein Drugs | Jianjun Cheng, Benjamin A. Teply, Seok Yoon Jeong, Christopher H. Yim and Dennis Ho, et al. |
| 565-572 | Direct Nose-to-Brain Transfer of Morphine After Nasal Administration to Rats | Ulrika Espefält Westin, Emma Boström, Johan Gråsjö, Margareta Hammarlund-Udenaes and Erik Björk |
| 573-579 | Thiolated Chitosans: Design and In Vivo Evaluation of a Mucoadhesive Buccal Peptide Drug Delivery System | Nina Langoth, Hermann Kahlbacher, Gudrun Schöffmann, Ivo Schmerold and Maximilian Schuh, et al. |
| 580-588 | Rapid Colorimetric Screening of Drug Interaction and Penetration Through Lipid Barriers | Marina Katz, Izek Ben-Shlush, Sofiya Kolusheva and Raz Jelinek |
| 589-594 | Salt Effects on an Ion–Molecule Reaction—Hydroxide-Catalyzed Hydrolysis of Benzocaine | Ahmad Al-Maaieh and Douglas R. Flanagan |
| 595-603 | Molar-Mass Characterization of Cationic Polymers for Gene Delivery by Aqueous Size-Exclusion Chromatography | Xulin Jiang, Aschwin van der Horst, Mies J. van Steenbergen, Niels Akeroyd and Cornelus F. van Nostrum, et al. |
| 604-613 | Evaluation and Optimization of the Conditions for an Improved Ferulic Acid Intercalation into a Synthetic Lamellar Anionic Clay | Aurélie Schoubben, Paolo Blasi, Stefano Giovagnoli, Morena Nocchetti and Maurizio Ricci, et al. |
| 614-622 | Enhanced Protein Delivery from Photopolymerized Hydrogels Using a Pseudospecific Metal Chelating Ligand | Chien-Chi Lin and Andrew T. Metters |
| 623-633 | PEGylated Peptide Dendrimeric Carriers for the Delivery of Antimalarial Drug Chloroquine Phosphate | D. Bhadra, S. Bhadra and N. K. Jain |
| 634-640 | A Study on the Effect of Wet Granulation on Microcrystalline Cellulose Particle Structure and Performance | Sherif I. Farag Badawy, David B. Gray and Munir A. Hussain |
| 641-642 | Reaction to the paper: Interaction of Polysorbate 80 with Erythropoietin: A Case Study in Protein–Surfactant Interactions | Suzanne Hermeling, Wim Jiskoot, Daan J. A. Crommelin and Huub Schellekens |
| 643-644 | Rebuttal Letter | George A. Heavner |
| 645-646 | AAPS Update
|
| 847-863 | Application of Micro- and Nano-Electromechanical Devices to Drug Delivery | Mark Staples, Karen Daniel, Michael J. Cima and Robert Langer |
| 864-872 | In Vitro Studies of Intestinal Permeability and Hepatic and Intestinal Metabolism of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops (Humulus lupulus L.) | Dejan Nikolic, Yongmei Li, Lucas R. Chadwick and Richard B. van Breemen |
| 873-881 | Brain Uptake of Nonsteroidal Anti-Inflammatory Drugs: Ibuprofen, Flurbiprofen, and Indomethacin | Jagan Mohan R. Parepally, Haritha Mandula and Quentin R. Smith |
| 882-891 | Recombinant Human Serum Albumin Dimer has High Blood Circulation Activity and Low Vascular Permeability in Comparison with Native Human Serum Albumin | Sadaharu Matsushita, Victor Tuan Giam Chuang, Masanori Kanazawa, Sumio Tanase and Keiichi Kawai, et al. |
| 892-900 | Efficacy of siRNA Nanocapsules Targeted Against the EWS–Fli1 Oncogene in Ewing Sarcoma | Nedjma Toub, Jean-Rémi Bertrand, Ali Tamaddon, Hind Elhamess and Hervé Hillaireau, et al. |
| 901-911 | Targeted High Lung Concentrations of Itraconazole Using Nebulized Dispersions in a Murine Model | Jason T. McConville, Kirk A. Overhoff, Prapasri Sinswat, Jason M. Vaughn and Bradi L. Frei, et al. |
| 912-919 | Synthesis and Enhancing Effect of Transkarbam 12 on the Transdermal Delivery of Theophylline, Clotrimazole, Flobufen, and Griseofulvin | Alexandr Hrabálek, Pavel Doležal, Kateřina Vávrová, Jarmila Zbytovská and Tomáš Holas, et al. |
| 920-930 | Comparison of Nanogel Drug Carriers and their Formulations with Nucleoside 5′-Triphosphates | Serguei V. Vinogradov, Ekta Kohli and Arin D. Zeman |
| 931-940 | Formulation and Characterization of Lipid-Coated Tobramycin Particles for Dry Powder Inhalation | Gabrielle Pilcer, Thami Sebti and Karim Amighi |
| 941-950 | Chitosan-Modified Dry Powder Formulations for Pulmonary Gene Delivery | Hao-Ying Li and James Birchall |
| 951-960 | A Novel in Vitro Percutaneous Penetration Model: Evaluation of Barrier Properties with P-Aminobenzoic Acid and Two of Its Derivatives | Miranda de Jager, Wouter Groenink, Ruth Bielsa i Guivernau, Elin Andersson and Nadezhda Angelova, et al. |
| 961-966 | β-Relaxation of Insulin Molecule in Lyophilized Formulations Containing Trehalose or Dextran as a Determinant of Chemical Reactivity | Sumie Yoshioka, Tamaki Miyazaki and Yukio Aso |
| 967-979 | Structural Relaxation of Acetaminophen Glass | Lina Gunawan, G. P. Johari and Ravi M. Shanker |
| 980-988 | Characterization of Complexes Between Naftifine and Cyclodextrins in Solution and in the Solid State | Maite Uzqueda, Carmen Martín, Arantza Zornoza, Miguel Sánchez and María Cristina Martínez-Ohárriz, et al. |
| 989-996 | Formulation of Solid Dosage Forms to Overcome Gastric pH Interaction of the Factor Xa Inhibitor, BMS-561389 | Sherif I. Farag Badawy, David B. Gray, Fang Zhao, Duxin Sun and Alan E. Schuster, et al. |
| 997-1007 | Insights into the Role of Electrostatic Forces on the Behavior of Dry Pharmaceutical Particulate Systems | Emilie DesRosiers Lachiver, Nicolas Abatzoglou, Louis Cartilier and Jean-Sébastien Simard |
| 1008-1019 | Polymer Microneedles for Controlled-Release Drug Delivery | Jung-Hwan Park, Mark G. Allen and Mark R. Prausnitz |
| 1020-1024 | Role of Phospholipid Transfer Protein on the Plasma Distribution of Amphotericin B Following the Incubation of Different Amphotericin B Formulations | Nilesh Patankar and Kishor M. Wasan |
| 1025-1030 | The in Vitro Plasma Distribution of a Novel Cholesteryl Ester Transfer Protein Inhibitor, Torcetrapib, Is Influenced by Differences in Plasma Lipid Concentrations | S. D. Lee, K. M. Wasan, A. Calcagni, M. Avery and F. McCush, et al. |
| 1031-1037 | Biopharmaceutical Characterization of the Telomerase Inhibitor BRACO19 | S. Taetz, C. Baldes, T. E. Mürdter, E. Kleideiter and K. Piotrowska, et al. |
| 1038-1042 | Biantennary Glycans as Well as Genetic Variants of α1-Acid Glycoprotein Control the Enantioselectivity and Binding Affinity of Oxybutynin | Tomoko Kimura, Akimasa Shibukawa and Katsumi Matsuzaki |
| 1043-1050 | Solid-State Characterization of Buspirone Hydrochloride Polymorphs | M. Sheikhzadeh, S. Rohani, A. Jutan, T. Manifar and K. Murthy, et al. |
| 1051-1052 | AAPS Update
|
| 1053-1074 | Plasmid Engineering for Controlled and Sustained Gene Expression for Nonviral Gene Therapy | Ethlinn V. B. van Gaal, Wim E. Hennink, Daan J. A. Crommelin and Enrico Mastrobattista |
| 1075-1088 | Metabonomics Techniques and Applications to Pharmaceutical Research & Development | John C. Lindon, Elaine Holmes and Jeremy K. Nicholson |
| 1089-1116 | CYP Induction-Mediated Drug Interactions: in Vitro Assessment and Clinical Implications | Jiunn H. Lin |
| 1117-1132 | Testosterone Hormone Replacement Therapy: State-of-the-Art and Emerging Technologies | Marie-Laure Leichtnam, Hervé Rolland, Patrick Wüthrich and Richard H. Guy |
| 1133-1143 | Effects of Antipsychotic Drugs on Ito, INa, Isus, IK1, and hERG: QT Prolongation, Structure Activity Relationship, and Network Analysis | William J. Crumb, Sean Ekins, R. Dustan Sarazan, James H. Wikel and Steven A. Wrighton, et al. |
| 1144-1156 | Oral Absorption of Poorly Water-Soluble Drugs: Computer Simulation of Fraction Absorbed in Humans from a Miniscale Dissolution Test | Ryusuke Takano, Kiyohiko Sugano, Atsuko Higashida, Yoshiki Hayashi and Minoru Machida, et al. |
| 1157-1164 | Adaptive Neuro-Fuzzy Modeling of Poorly Soluble Drug Formulations | Dionysios Douroumis, Leontios J. Hadjileontiadis and Alfred Fahr |
| 1165-1177 | Saturable Absorptive Transport of the Hydrophilic Organic Cation Ranitidine in Caco-2 Cells: Role of pH-Dependent Organic Cation Uptake System and P-Glycoprotein | David L. Bourdet and Dhiren R. Thakker |
| 1178-1187 | Intestinal Absorptive Transport of the Hydrophilic Cation Ranitidine: A Kinetic Modeling Approach to Elucidate the Role of Uptake and Efflux Transporters and Paracellular vs. Transcellular Transport in Caco-2 Cells | David L. Bourdet, Gary M. Pollack and Dhiren R. Thakker |
| 1188-1200 | Hepatic CYP3A Expression is Attenuated in Obese Mice Fed a High-Fat Diet | Kouichi Yoshinari, Shunsuke Takagi, Teruyasu Yoshimasa, Junko Sugatani and Masao Miwa |
| 1201-1208 | Characteristics of Substance P Transport Across the Blood–Brain Barrier | Arvind K. Chappa, Kenneth L. Audus and Susan M. Lunte |
| 1209-1216 | Interaction of Ibuprofen and Other Structurally Related NSAIDs with the Sodium-Coupled Monocarboxylate Transporter SMCT1 (SLC5A8) | Shirou Itagaki, Elangovan Gopal, Lina Zhuang, You-Jun Fei and Seiji Miyauchi, et al. |
| 1217-1226 | Nasal Immunization with Anthrax Protective Antigen Protein Adjuvanted with Polyriboinosinic–Polyribocytidylic Acid Induced Strong Mucosal and Systemic Immunities | Brian R. Sloat and Zhengrong Cui |
| 1227-1234 | Glucose Partition Coefficient and Diffusivity in the Lower Skin Layers | Enam Khalil, Kosmas Kretsos and Gerald B. Kasting |
| 1235-1242 | ATP-Binding Cassette Transporter G2 Mediates the Efflux of Phototoxins on the Luminal Membrane of Retinal Capillary Endothelial Cells | Tomoko Asashima, Satoko Hori, Sumio Ohtsuki, Masanori Tachikawa and Masahiko Watanabe, et al. |
| 1243-1250 | Enhanced Oral Paclitaxel Bioavailability After Administration of Paclitaxel-Loaded Lipid Nanocapsules | Sandra Peltier, Jean-Michel Oger, Frédéric Lagarce, William Couet and Jean-Pierre Benoît |
| 1251-1264 | A Specific Picomolar Hybridization-Based ELISA Assay for the Determination of Phosphorothioate Oligonucleotides in Plasma and Cellular Matrices | Xiaohui Wei, Guowei Dai, Guido Marcucci, Zhongfa Liu and Dale Hoyt, et al. |
| 1265-1274 | Nontoxic Suramin as a Chemosensitizer in Patients: Dosing Nomogram Development | Danny Chen, Sae Heum Song, M. Guillaume Wientjes, Teng Kuang Yeh and Liang Zhao, et al. |
| 1275-1284 | Rationale for Fixed Dosing of Pertuzumab in Cancer Patients Based on Population Pharmacokinetic Analysis | Chee M. Ng, Bert L. Lum, Veronica Gimenez, Steve Kelsey and David Allison |
| 1285-1294 | Gd-DTPA l-Cystine Bisamide Copolymers as Novel Biodegradable Macromolecular Contrast Agents for MR Blood Pool Imaging | Todd L. Kaneshiro, Tianyi Ke, Eun-Kee Jeong, Dennis L. Parker and Zheng-Rong Lu |
| 1295-1305 | The Influence of Surfactant on PLGA Microsphere Glass Transition and Water Sorption: Remodeling the Surface Morphology to Attenuate the Burst Release | C. Bouissou, J. J. Rouse, R. Price and C. F. van der Walle |
| 1306-1312 | Hydrolytic Degradation and Drug Release of Ricinoleic Acid–Lactic Acid Copolyesters | Raia Slivniak, Aviva Ezra and Abraham J. Domb |
| 1313-1323 | Complement Activation by Core–Shell Poly(isobutylcyanoacrylate)–Polysaccharide Nanoparticles: Influences of Surface Morphology, Length, and Type of Polysaccharide | Isabelle Bertholon, Christine Vauthier and Denis Labarre |
| 1324-1331 | Expression of Basic Fibroblast Growth Factor Correlates with Resistance to Paclitaxel in Human Patient Tumors | Yuebo Gan, M. Guillaume Wientjes and Jessie L.-S. Au |
| 1332-1342 | Reverse Hexagonal Phase Nanodispersion of Monoolein and Oleic Acid for Topical Delivery of Peptides: | 1343-1349 | Electron Beam and Gamma Radiolysis of Solid-State Metoclopramide | Aubert Maquille, Catherine Slegers, Jean-Louis Habib and Bernard Tilquin |
| 1350-1363 | FTIR and nDSC as Analytical Tools for High-Concentration Protein Formulations | Susanne Matheus, Wolfgang Friess and Hanns-Christian Mahler |
| 1364-1372 | Effect of Oropharyngeal Length in Drug Lung Delivery via Suspension Pressurized Metered Dose Inhalers | T. Ehtezazi, D. R. Allanson, I. D. Jenkinson and C. O'Callaghan |
| 1373-1381 | Canine Intestinal Contents vs. Simulated Media for the Assessment of Solubility of Two Weak Bases in the Human Small Intestinal Contents | Lida Kalantzi, Eva Persson, Britta Polentarutti, Bertil Abrahamsson and Konstantinos Goumas, et al. |
| 1382-1394 | Protein Structural Conformation and Not Second Virial Coefficient Relates to Long-Term Irreversible Aggregation of a Monoclonal Antibody and Ovalbumin in Solution | Harminder Bajaj, Vikas K. Sharma, Advait Badkar, David Zeng and Sandeep Nema, et al. |
| 1395-1400 | Design and Evaluation of Celecoxib Porous Particles using Melt Sonocrystallization | Anant Paradkar, Manish Maheshwari, Ravindra Kamble, Ian Grimsey and Peter York |
| 1401-1402 | AAPS Update
| |
| 2233-2234 | A Tribute to George Zografi: Four Decades of Cutting-Edge Research in Interfacial Phenomena | Vincent H. L. Lee |
| 2235-2238 | George Zografi: Researcher and Educator | Paul M. Bummer and Mehran Yazdanian |
| 2239-2253 | Kinetics and Mechanism for the Reaction of Cysteine with Hydrogen Peroxide in Amorphous Polyvinylpyrrolidone Lyophiles | Dayong Luo and Bradley D. Anderson |
| 2254-2268 | Coupling Between Chemical Reactivity and Structural Relaxation in Pharmaceutical Glasses | Sheri L. Shamblin, Bruno C. Hancock and Michael J. Pikal |
| 2269-2276 | A Calorimetric Method to Estimate Molecular Mobility of Amorphous Solids at Relatively Low Temperatures | Chen Mao, Sai Prasanth Chamarthy, Stephen R. Byrn and Rodolfo Pinal |
| 2277-2290 | Predictions of Onset of Crystallization from Experimental Relaxation Times I-Correlation of Molecular Mobility from Temperatures Above the Glass Transition to Temperatures Below the Glass Transition | Chandan Bhugra, Rama Shmeis, Steven L. Krill and Michael J. Pikal |
| 2291-2305 | Rapid Assessment of the Structural Relaxation Behavior of Amorphous Pharmaceutical Solids: Effect of Residual Water on Molecular Mobility | Danforth P. Miller and David Lechuga-Ballesteros |
| 2306-2316 | A Comparison of the Physical Stability of Amorphous Felodipine and Nifedipine Systems | Patrick J. Marsac, Hajime Konno and Lynne S. Taylor |
| 2317-2325 | Amorphization of Indomethacin by Co-Grinding with Neusilin US2: Amorphization Kinetics, Physical Stability and Mechanism | Deepak Bahl and Robin H. Bogner |
| 2326-2332 | Empirically Augmented Density Functional Theory for Predicting Lattice Energies of Aspirin, Acetaminophen Polymorphs, and Ibuprofen Homochiral and Racemic Crystals | Tonglei Li and Shaoxin Feng |
| 2333-2349 | Analysis of Amorphous and Nanocrystalline Solids from Their X-Ray Diffraction Patterns | Simon Bates, George Zografi, David Engers, Kenneth Morris and Kieran Crowley, et al. |
| 2350-2355 | Surface Crystallization of Indomethacin Below Tg | Tian Wu and Lian Yu |
| 2356-2367 | Structure in Dehydrated Trehalose Dihydrate—Evaluation of the Concept of Partial Crystallinity | Meena Rani, Ramprakash Govindarajan, Rahul Surana and Raj Suryanarayanan |
| 2368-2374 | Solute Crystallization in Frozen Systems–Use of Synchrotron Radiation to Improve Sensitivity | Dushyant B. Varshney, Satyendra Kumar, Evgenyi Y. Shalaev, Shin-Woong Kang and Larry A. Gatlin, et al. |
| 2375-2380 | Additive-Induced Metastable Single Crystal of Mefenamic Acid | Eun Hee Lee, Stephen R. Byrn and M. Teresa Carvajal |
| 2381-2392 | Cocrystal Formation during Cogrinding and Storage is Mediated by Amorphous Phase | Adivaraha Jayasankar, Anongnat Somwangthanaroj, Zezhi J. Shao and Naír Rodríguez-Hornedo |
| 2393-2404 | Investigation of the Multi-Step Dehydration Reaction of Theophylline Monohydrate Using 2-Dimensional Powder X-ray Diffractometry | Cletus Nunes, Arumugam Mahendrasingam and Raj Suryanarayanan |
| 2405-2412 | General Trends in the Desolvation Behavior of Calcium Salts | Faraj Atassi and Stephen R. Byrn |
| 2413-2416 | Formation of Cholesterol Crystals at a Mucin Coated Substrate | Xiangmin Liao and Timothy S. Wiedmann |
| 2417-2426 | Theoretical and Practical Approaches for Prediction of Drug–Polymer Miscibility and Solubility | Patrick J. Marsac, Sheri L. Shamblin and Lynne S. Taylor |
| 2427-2440 | Percolative Transport and Cluster Diffusion Near and Below the Percolation Threshold of a Porous Polymeric Matrix | Jayne E. Hastedt and James L. Wright |
| 2441-2453 | Modeling of Aqueous Transport in Rigid Porous Matrices near the Percolation Threshold | Scott R. Ellis and James L. Wright |
| 2454-2468 | Ionization States in the Microenvironment of Solid Dosage Forms: Effect of Formulation Variables and Processing | Ramprakash Govindarajan, Andrey Zinchuk, Bruno Hancock, Evgenyi Shalaev and Raj Suryanarayanan |
| 2469-2474 | Continuous Measurement of the Lipoxygenase-Catalyzed Oxidation of Unsaturated Lipids Using the Monomolecular Film Technique | Abdelkarim Abousalham and Robert Verger |
| 2475-2481 | A ‘Rule of Unity’ for Human Intestinal Absorption | S. H. Yalkowsky, J. L. H. Johnson, T. Sanghvi and S. G. Machatha |
| 2482-2490 | Mass Transport Properties of Progesterone and Estradiol in Model Microemulsion Formulations | Laura M. Land, Ping Li and Paul M. Bummer |
| 2491-2492 | AAPS Update
|
| 2493-2504 | Real-time Imaging and Quantification of Brain Delivery of Liposomes | Michal T. Krauze, John Forsayeth, John W. Park and Krystof S. Bankiewicz |
| 2505-2514 | Protection Against Chemotherapy-Induced Alopecia | Jie Wang, Ze Lu and Jessie L.-S. Au |
| 2515-2524 | Micronutrient and Urate Transport in Choroid Plexus and Kidney: Implications for Drug Therapy | Reynold Spector and Conrad Johanson |
| 2525-2535 | PAMPA–Excipient Classification Gradient Map | Stefanie Bendels, Oksana Tsinman, Björn Wagner, Dana Lipp and Isabelle Parrilla, et al. |
| 2536-2541 | Regulation of Exogenous Gene Expression by Superoxide | Atsushi Kinoshita, Daisuke Kobayashi, Yukiya Saitoh, Naoto Tanabe and Katsuyoshi Uchino, et al. |
| 2542-2555 | Polymorph Farming of Acetaminophen and Sulfathiazole on a Chip | Tu Lee, Shi Ting Hung and Chung Shin Kuo |
| 2556-2565 | Agglomerate Strength and Dispersion of Salmeterol Xinafoate from Powder Mixtures for Inhalation | Handoko Adi, Ian Larson, Herbert Chiou, Paul Young and Daniela Traini, et al. |
| 2566-2574 | Molecular Interaction among Probucol/PVP/SDS Multicomponent System Investigated by Solid-State NMR | Adchara Pongpeerapat, Kenjirou Higashi, Yuichi Tozuka, Kunikazu Moribe and Keiji Yamamoto |
| 2575-2585 | A Parenteral Econazole Formulation Using a Novel Micelle-to-Liposome Transfer Method: In Vitro Characterization and Tumor Growth Delay in a Breast Cancer Xenograft Model | Sebastian Cogswell, Stuart Berger, Dawn Waterhouse, Marcel B. Bally and Ellen K. Wasan |
| 2586-2594 | Induction of Heme Oxygenase-1 (HO-1) and NAD[P]H: Quinone Oxidoreductase 1 (NQO1) by a Phenolic Antioxidant, Butylated Hydroxyanisole (BHA) and Its Metabolite, tert-Butylhydroquinone (tBHQ) in Primary-Cultured Human and Rat Hepatocytes | Young-Sam Keum, Yong-Hae Han, Celine Liew, Jung-Hwan Kim and Changjiang Xu, et al. |
| 2595-2602 | Data Analysis of Kinetic Modelling Used in Drug Stability Studies: Isothermal Versus Nonisothermal Assays | Alexis Oliva, Matías Llabrés and José B. Fariña |
| 2603-2610 | 4-Hydroxyacetophenone-Induced Choleresis in Rats is Mediated by the Mrp2-Dependent Biliary Secretion of Its Glucuronide Conjugate | Chitrawina Mahagita, Khwanchit Tanphichai, Apichart Suksamrarn, Nazzareno Ballatori and Pawinee Piyachaturawat |
| 2611-2620 | Chemical and Thermal Stability of Insulin: Effects of Zinc and Ligand Binding to the Insulin Zinc-Hexamer | Kasper Huus, Svend Havelund, Helle B. Olsen, Marco van de Weert and Sven Frokjaer |
| 2621-2637 | Pharmacogenomics of Phenolic Antioxidant Butylated Hydroxyanisole (BHA) in the Small Intestine and Liver of Nrf2 Knockout and C57BL/6J Mice | Sujit Nair, Changjiang Xu, Guoxiang Shen, Vidya Hebbar and Avantika Gopalakrishnan, et al. |
| 2638-2645 | Intracellular Delivery of Saquinavir in Biodegradable Polymeric Nanoparticles for HIV/AIDS | Lipa K. Shah and Mansoor M. Amiji |
| 2646-2656 | Characterization of Hepatobiliary Transport Systems of a Novel | 2657-2664 | Novel Scaled Bioequivalence Limits with Leveling-off Properties | John Kytariolos, Vangelis Karalis, Panos Macheras and Mira Symillides |
| 2665-2671 | P2Y Receptor Mediated Modulation of Insulin Release by a Novel Generation of 2-Substituted-5′-O-(1-Boranotriphosphate)-Adenosine Analogues | Anne Farret, Romain Filhol, Nathalie Linck, Michèle Manteghetti and Jacques Vignon, et al. |
| 2672-2680 | Influence of Dyslipidemia on Moxidectin Distribution in Plasma Lipoproteins and on its Pharmacokinetics | Mohamad Firas Bassissi, Michel Alvinerie, Pascal Guy Pierre Martin, Bertrand Perret and Anne Lespine |
| 2681-2688 | Bioavailability of Seocalcitol IV: Evaluation of Lymphatic Transport in Conscious Rats | Mette Grove, Jeanet L. Nielsen, Gitte P. Pedersen and Anette Müllertz |
| 2689-2690 | AAPS Update
| |
| 1-16 | Micellar Nanocarriers: Pharmaceutical Perspectives | V. P. Torchilin |
| 17-27 | Controlling Protein Compartmentalization to Overcome Disease | James R. Davis, Mudit Kakar and Carol S. Lim |
| 28-36 | Molecular Insights into the Structure–Function Relationship of Organic Anion Transporters OATs | Fanfan Zhou and Guofeng You |
| 37-47 | Disruption of Epithelial Tight Junctions by Yeast Enhances the Paracellular Delivery of a Model Protein | Emily Fuller, Craig Duckham and Edward Wood |
| 48-57 | Modeling Cardiac Uptake and Negative Inotropic Response of Verapamil in Rat Heart: Effect of Amiodarone | Pakawadee Sermsappasuk, Osama Abdelrahman and Michael Weiss |
| 58-65 | Raman Mapping of Low-Content API Pharmaceutical Formulations. I. Mapping of Alprazolam in Alprazolam/Xanax Tablets | Slobodan Šašić |
| 66-72 | A Charge Pair Interaction Between Arg282 in Transmembrane Segment 7 and Asp341 in Transmembrane Segment 8 of hPepT1 | Ashutosh A. Kulkarni, Daryl L. Davies, Jennifer S. Links, Leena N. Patel and Vincent H. L. Lee, et al. |
| 73-80 | A Modern View of Excipient Effects on Bioequivalence: Case Study of Sorbitol | M.-L. Chen, A. B. Straughn, N. Sadrieh, M. Meyer and P. J. Faustino, et al. |
| 81-89 | Involvement of UDP-Glucuronosyltransferases in the Extensive Liver and Intestinal First-Pass Metabolism of Flavonoid Baicalein | Li Zhang, Ge Lin and Zhong Zuo |
| 90-98 | Characterization of the Uptake Mechanism for a Novel Loop Diuretic, M17055, in Caco-2 Cells: Involvement of Organic Anion Transporting Polypeptide (OATP)-B | Tomohiro Nishimura, Yoshiyuki Kubo, Yukio Kato, Yoshimichi Sai and Takuo Ogihara, et al. |
| 99-110 | Aqueous-Soluble, Non-Reversible Lipid Conjugate of Salmon Calcitonin: Synthesis, Characterization and In Vivo Activity | Weiqiang Cheng, Seetharama Satyanarayanajois and Lee-Yong Lim |
| 111-124 | Effect of Particle Size and Compression Force on Compaction Behavior and Derived Mathematical Parameters of Compressibility | Sarsvatkumar Patel, Aditya Mohan Kaushal and Arvind Kumar Bansal |
| 125-135 | In Vitro Investigation of Drug Particulates Interactions and Aerosol Performance of Pressurised Metered Dose Inhalers | Daniela Traini, Paul M. Young, Philippe Rogueda and Robert Price |
| 136-146 | Sorbitol Crystallization Can Lead to Protein Aggregation in Frozen Protein Formulations | Deirdre Murphy Piedmonte, Christie Summers, Arnold McAuley, Lejla Karamujic and Gayathri Ratnaswamy |
| 147-156 | Effect of Small Levels of Impurities on the Water Vapor Sorption Behavior of Ranitidine HCl | Peter Guerrieri, Adnan K. Salameh and Lynne S. Taylor |
| 157-167 | Thiolated Chitosan/DNA Nanocomplexes Exhibit Enhanced and Sustained Gene Delivery | Dongwon Lee, Weidong Zhang, Shawna A. Shirley, Xiaoyuan Kong and Gary R. Hellermann, et al. |
| 168-175 | Moisture-Induced Aggregation of Lyophilized DNA and its Prevention | Vikas K. Sharma and Alexander M. Klibanov |
| 176-185 | Antiangiogenic Effect of Bile Acid Acylated Heparin Derivative | Kyeongsoon Park, Yoo-Shin Kim, Gee Young Lee, Ju-Ock Nam and Seok Ki Lee, et al. |
| 186-193 | Near Infrared Spectrometry for the Quantification of Human Dermal Absorption of Econazole Nitrate and Estradiol | Joseph P. Medendorp, Kalpana S. Paudel, Robert A. Lodder and Audra L. Stinchcomb |
| 194-200 | Rational Design of a Dual-Mode Optical and Chemical Prodrug | Colin P. McCoy, Clare Rooney, David S. Jones, Sean P. Gorman and Mark Nieuwenhuyzen |
| 201-202 | AAPS Update
|
| 411-437 | Particle Engineering for Pulmonary Drug Delivery | Albert H. L. Chow, Henry H. Y. Tong, Pratibhash Chattopadhyay and Boris Y. Shekunov |
| 438-449 | Lipid-based Nanoparticles for Nucleic Acid Delivery | Weijun Li and Francis C. Szoka |
| 450-470 | Organic Anion Transporters of the SLC22 Family: Biopharmaceutical, Physiological, and Pathological Roles | Ahsan N. Rizwan and Gerhard Burckhardt |
| 471-479 | Best Practices for Managing Quality and Safety of Foreign Particles in Orally Inhaled and Nasal Drug Products, and an Evaluation of Clinical Relevance | James Blanchard, James Coleman, Courtney Crim, Claire D’Abreu-Hayling and Lou Fries, et al. |
| 480-501 | Predicting the Oxidative Metabolism of Statins: An Application of the MetaSite® Algorithm | Giulia Caron, Giuseppe Ermondi and Bernard Testa |
| 502-511 | Interplay of Secondary Structure and Charge on the Diffusion of a Polypeptide through Negatively Charged Aqueous Pores | Montakarn Chittchang, Ashim K. Mitra and Thomas P. Johnston |
| 512-520 | Characterization of the Physiological Spaces and Distribution of Tolbutamide in the Perfused Rat Pancreas | Kent John Fanning and Michael S. Roberts |
| 521-529 | Enhanced Release of Indomethacin from PVP/Stearic Acid Microcapsules Prepared Coupling Co-freeze-drying and Ultrasound Assisted Spray-congealing Process | Cristina Cavallari, Barbara Luppi, Anna Maria Di Pietra, Lorenzo Rodriguez and Adamo Fini |
| 530-545 | Solubility-Excipient Classification Gradient Maps | Alex Avdeef, Stefanie Bendels, Oksana Tsinman, Konstantin Tsinman and Manfred Kansy |
| 546-554 | Intestinal Absorption of Miltefosine: Contribution of Passive Paracellular Transport | Cécile Ménez, Marion Buyse, Christophe Dugave, Robert Farinotti and Gillian Barratt |
| 555-565 | Paclitaxel-2′-Ethylcarbonate Prodrug Can Circumvent P-glycoprotein-mediated Cellular Efflux to Increase Drug Cytotoxicity | Tadatoshi Tanino, Akihiro Nawa, Eisaku Kondo, Fumitaka Kikkawa and Tohru Daikoku, et al. |
| 566-574 | Targeting 15d-Prostaglandin J2 to Hepatic Stellate Cells: Two Options Evaluated | Werner I. Hagens, Adriana Mattos, Rick Greupink, Alie de Jager-Krikken and Catharina Reker-Smit, et al. |
| 575-584 | Transport of Nicotinate and Structurally Related Compounds by Human SMCT1 (SLC5A8) and Its Relevance to Drug Transport in the Mammalian Intestinal Tract | Elangovan Gopal, Seiji Miyauchi, Pamela M. Martin, Sudha Ananth and Penny Roon, et al. |
| 585-592 | Comparative Evaluation of Ibuprofen/β-Cyclodextrin Complexes Obtained by Supercritical Carbon Dioxide and Other Conventional Methods | Khaled Hussein, Michael Türk and Martin A. Wahl |
| 593-604 | Glycine Crystallization in Frozen and Freeze-dried Systems: Effect of pH and Buffer Concentration | Dushyant B. Varshney, Satyendra Kumar, Evgenyi Y. Shalaev, Prakash Sundaramurthi and Shin-Woong Kang, et al. |
| 605-612 | Assessment of Performance of Manufacturing Procedures in a Unit for Production of Investigational Anticancer Agents, Using a Mixed Effects Analysis | S. C. van der Schoot, B. Nuijen, A. D. R. Huitema and J. H. Beijnen |
| 613-614 | AAPS Update
|
| 615-617 | Reviewers for Pharmaceutical Research (Volume 23) for the Period of January 1, 2006 to December 31, 2006 |
| 618-627 | Encapsulation of Nucleic Acids and Opportunities for Cancer Treatment | Lisa Brannon-Peppas, Bilal Ghosn, Krishnendu Roy and Kenneth Cornetta |
| 628-642 | Differentiation Restricted Endocytosis of Cell Penetrating Peptides in MDCK Cells Corresponds with Activities of Rho-GTPases | Christina Foerg, Urs Ziegler, Jimena Fernandez-Carneado, Ernest Giralt and Hans P. Merkle |
| 643-649 | Application of Scaling Factors in Simultaneous Modeling of Microarray Data from Diverse Chips | Zhenling Yao, Baiteng Zhao, Eric P. Hoffman, Svetlana Ghimbovschi and Debra C. DuBois, et al. |
| 650-661 | Spray-drying Nanocapsules in Presence of Colloidal Silica as Drying Auxiliary Agent: Formulation and Process Variables Optimization Using Experimental Designs | Patrice Tewa-Tagne, Ghania Degobert, Stéphanie Briançon, Claire Bordes and Jean-Yves Gauvrit, et al. |
| 662-671 | Involvement of Indoxyl Sulfate in Renal and Central Nervous System Toxicities During Cisplatin-induced Acute Renal Failure | Kazufumi Iwata, Hiroshi Watanabe, Takafumi Morisaki, Takanobu Matsuzaki and Takafumi Ohmura, et al. |
| 672-678 | The Influence of Hyperlipoproteinemia on in Vitro Distribution of Amiodarone and Desethylamiodarone in Human and Rat Plasma | Anooshirvan Shayeganpour, Stephen D. Lee, Kishor M. Wasan and Dion R. Brocks |
| 679-687 | Novel Cyclic Phosphate Prodrug Approach for Cytochrome P450-activated Drugs Containing an Alcohol Functionality | Kristiina M. Huttunen, Niina Mähönen, Jukka Leppänen, Jouko Vepsäläinen and Risto O. Juvonen, et al. |
| 688-694 | Establishing a Method to Isolate Rat Brain Capillary Endothelial Cells by Magnetic Cell Sorting and Dominant mRNA Expression of Multidrug Resistance-associated Protein 1 and 4 in Highly Purified Rat Brain Capillary Endothelial Cells | Sumio Ohtsuki, Hirofumi Yamaguchi, Tomoko Asashima and Tetsuya Terasaki |
| 695-704 | A Novel Method to Radiolabel Gastric Retentive Formulations for Gamma Scintigraphy Assessment | Matthew D. Burke, J. Scott Staton, Ann W. Vickers, Erin E. Peters and Mark D. Coffin |
| 705-714 | Antiangiogenic and Apoptotic Properties of a Novel Amphiphilic Folate-Heparin-Lithocholate Derivative Having Cellular Internality for Cancer Therapy | Mi Kyung Yu, Dong Yun Lee, Yoo Shin Kim, Kyeongsoon Park and Soo Ah Park, et al. |
| 715-727 | Drying-Induced Variations in Physico-Chemical Properties of Amorphous Pharmaceuticals and Their Impact on Stability II: Stability of a Vaccine | Ahmad M. Abdul-Fattah, Vu Truong-Le, Luisa Yee, Emilie Pan and Yi Ao, et al. |
| 728-737 | Formulation and In-Vitro and In-Vivo Evaluation of a Mucoadhesive Gel Containing Freeze Dried Black Raspberries: Implications for Oral Cancer Chemoprevention | Susan R. Mallery, Gary D. Stoner, Peter E. Larsen, Henry W. Fields and Kapila A. Rodrigo, et al. |
| 738-747 | Isothermal Crystallization of Imwitor 742 from Supercooled Liquid State | Kohsaku Kawakami |
| 748-757 | Increasing the Proportional Content of Surfactant (Cremophor EL) Relative to Lipid in Self-emulsifying Lipid-based Formulations of Danazol Reduces Oral Bioavailability in Beagle Dogs | Jean F. Cuiné, William N. Charman, Colin W. Pouton, Glenn A. Edwards and Christopher J. H. Porter |
| 758-772 | An Assessment of Recombinant Human Erythropoietin Effect on Reticulocyte Production Rate and Lifespan Distribution in Healthy Subjects | Wojciech Krzyzanski and Juan Jose Perez-Ruixo |
| 773-779 | Adenoviral Gene Delivery to Solid Tumors by Recombinant Silk–Elastinlike Protein Polymers | A. Hatefi, J. Cappello and H. Ghandehari |
| 780-790 | Improved Protocol and Data Analysis for Accelerated Shelf-Life Estimation of Solid Dosage Forms | Kenneth C. Waterman, Anthony J. Carella, Michael J. Gumkowski, Patrick Lukulay and Bruce C. MacDonald, et al. |
| 791-802 | Levodopa Slows Progression of Parkinson’s Disease. External Validation by Clinical Trial Simulation | Phylinda L. S. Chan, John G. Nutt and Nicholas H. G. Holford |
| 803-810 | Surfactant-polymer Nanoparticles: A Novel Platform for Sustained and Enhanced Cellular Delivery of Water-soluble Molecules | Mahesh D. Chavanpatil, Ayman Khdair and Jayanth Panyam |
| 811-815 | Renal Transport of Adefovir, Cidofovir, and Tenofovir by SLC22A Family Members (hOAT1, hOAT3, and hOCT2) | Yuichi Uwai, Hiroki Ida, Yoshie Tsuji, Toshiya Katsura and Ken-ichi Inui |
| 816-817 | AAPS Update
|
| 1227-1251 | Polyspecific Organic Cation Transporters: Structure, Function, Physiological Roles, and Biopharmaceutical Implications | Hermann Koepsell, Katrin Lips and Christopher Volk |
| 1252-1261 | Dosage Form Development, in Vitro Release Kinetics, and in Vitro–in Vivo Correlation for Leuprolide Released from an Implantable Multi-reservoir Array | James H. Prescott, Timothy J. Krieger, Sara Lipka and Mark A. Staples |
| 1262-1274 | Expression of the ATP-binding Cassette Membrane Transporter, ABCG2, in Human and Rodent Brain Microvessel Endothelial and Glial Cell Culture Systems | Gloria Lee, Karlo Babakhanian, Manisha Ramaswamy, Alexandre Prat and Karolina Wosik, et al. |
| 1275-1282 | Development and Validation of a Physiology-based Model for the Prediction of Oral Absorption in Monkeys | Stefan Willmann, Andrea N. Edginton and Jennifer B. Dressman |
| 1283-1289 | An Oral Adsorbent, AST-120 Protects Against the Progression of Oxidative Stress by Reducing the Accumulation of Indoxyl Sulfate in the Systemic Circulation in Renal Failure | Kazuki Shimoishi, Makoto Anraku, Kenichiro Kitamura, Yuka Tasaki and Kazuaki Taguchi, et al. |
| 1290-1298 | Proline Prodrug of Melphalan Targeted to Prolidase, a Prodrug Activating Enzyme Overexpressed in Melanoma | Sachin Mittal, Xueqin Song, Balvinder S. Vig and Gordon L. Amidon |
| 1299-1308 | Modeling Methadone Pharmacokinetics in Rats in Presence of P-glycoprotein Inhibitor Valspodar | Ignacio Ortega, Monica Rodriguez, Elena Suarez, Juan Jose Perez-Ruixo and Rosario Calvo |
| 1309-1324 | Novel L-Dopa and Dopamine Prodrugs Containing a 2-Phenyl-imidazopyridine Moiety | Nunzio Denora, Valentino Laquintana, Angela Lopedota, Mariangela Serra and Laura Dazzi, et al. |
| 1325-1335 | Confocal Microscopy for the Elucidation of Mass Transport Mechanisms Involved in Protein Release from Lipid-based Matrices | Stephanie Koennings, Joerg Tessmar, Torsten Blunk and Achim Göpferich |
| 1336-1345 | Melittin as an Epithelial Permeability Enhancer I: Investigation of Its Mechanism of Action in Caco-2 Monolayers | Sam Maher, Linda Feighery, David J. Brayden and Siobhán McClean |
| 1346-1356 | Melittin as a Permeability Enhancer II: In Vitro Investigations in Human Mucus Secreting Intestinal Monolayers and Rat Colonic Mucosae | Sam Maher, Linda Feighery, David J. Brayden and Siobhán McClean |
| 1357-1359 | Theme Section: Transdermal Delivery of Proteins | Ajay K. Banga |
| 1360-1368 | Transdermal Delivery of Cytochrome C—A 12.4 kDa Protein—Across Intact Skin by Constant–Current Iontophoresis | J. Cázares-Delgadillo, A. Naik, A. Ganem-Rondero, D. Quintanar-Guerrero and Y. N. Kalia |
| 1369-1380 | Coating Formulations for Microneedles | Harvinder S. Gill and Mark R. Prausnitz |
| 1381-1388 | Novel Microneedle Patches for Active Insulin Delivery are Efficient in Maintaining Glycaemic Control: An Initial Comparison with Subcutaneous Administration | Lina Nordquist, Niclas Roxhed, Patrick Griss and Göran Stemme |
| 1389-1395 | Transdermal Delivery of Interferon Alpha-2B using Microporation and Iontophoresis in Hairless Rats | Advait V. Badkar, Alan M. Smith, Jonathan A. Eppstein and Ajay K. Banga |
| 1396-1401 | Ultrasound Mediated Transdermal Insulin Delivery in Pigs Using a Lightweight Transducer | E. J. Park, Jacob Werner and Nadine Barrie Smith |
| 1402-1403 | AAPS Update
|
| 1977-1992 | Cell Penetrating Peptides: Intracellular Pathways and Pharmaceutical Perspectives | Leena N. Patel, Jennica L. Zaro and Wei-Chiang Shen |
| 1993-2004 | P-Glycoprotein in Proteoliposomes with Low Residual Detergent: The Effects of Cholesterol | Karsten Bucher, Sara Belli, Heidi Wunderli-Allenspach and Stefanie D. Krämer |
| 2005-2007 | Enhancing Drug Development and Drug Monitoring: Academia, Industry and Government Chart Common Goals | Walter Wolf, Dennis J. Atkinson and Patrick M. Colletti |
| 2008-2017 | Determination of the Relative Bioavailability of Salbutamol to the Lungs Following Inhalation from Dry Powder Inhaler Formulations Containing Drug Substance Manufactured by Supercritical Fluids and Micronization | Catherine H. Richardson, Marcel de Matas, Harold Hosker, Rahul Mukherjee and Ian Wong, et al. |
| 2018-2024 | Reliability and Reproducibility of Vertical Diffusion Cells for Determining Release Rates from Semisolid Dosage Forms | Walter W. Hauck, Vinod P. Shah, Steven W. Shaw and Clarence T. Ueda |
| 2025-2030 | Residence Time Dispersion as a General Measure of Drug Distribution Kinetics: Estimation and Physiological Interpretation | Michael Weiss |
| 2031-2039 | Allometric Scaling of Pharmacodynamic Responses: Application to 5-Ht1A Receptor Mediated Responses from Rat to Man | Klaas P. Zuideveld, Piet H. Van der Graaf, Lambertus A. Peletier and Meindert Danhof |
| 2040-2047 | Cytosolic Delivery of Liposomally Targeted Proteins Induced by Photochemical Internalization | Marjan M. Fretz, Anders Høgset, Gerben A. Koning, Wim Jiskoot and Gert Storm |
| 2048-2054 | Nanoscale Characterisation and Imaging of Partially Amorphous Materials using Local Thermomechanical Analysis and Heated Tip AFM | Ljiljana Harding, William P. King, Xuan Dai, Duncan Q. M. Craig and Mike Reading |
| 2055-2062 | Immunoadsorption of Alloantibodies onto Erythroid Membrane Antigens Encapsulated into Polymeric Microparticles | Valérie Hoffart, Philippe Maincent, Alf Lamprecht, Véronique Latger-Cannard and Véronique Regnault, et al. |
| 2063-2070 | Binding of Betaxolol, Metoprolol and Oligonucleotides to Synthetic and Bovine Ocular Melanin, and Prediction of Drug Binding to Melanin in Human Choroid-Retinal Pigment Epithelium | Leena Pitkänen, Veli-Pekka Ranta, Hanna Moilanen and Arto Urtti |
| 2071-2083 | A High-Throughput Method for Detection of Protein Self-Association and Second Virial Coefficient Using Size-Exclusion Chromatography Through Simultaneous Measurement of Concentration and Scattered Light Intensity | Harminder Bajaj, Vikas K. Sharma and Devendra S. Kalonia |
| 2084-2096 | Low Dose Lipid Formulations: Effects on Gastric Emptying and Biliary Secretion | Greg A. Kossena, William N. Charman, Clive G. Wilson, Bridget O’Mahony and Blythe Lindsay, et al. |
| 2097-2098 | Intracellular Delivery | Tamara Minko |
| 2099-2109 | Micelles of Different Morphologies—Advantages of Worm-like Filomicelles of PEO-PCL in Paclitaxel Delivery | Shenshen Cai, Kandaswamy Vijayan, Debbie Cheng, Eliana M. Lima and Dennis E. Discher |
| 2110-2119 | Peritoneal Macrophage Uptake, Pharmacokinetics and Biodistribution of Macrophage-Targeted PEG-fMLF (N-Formyl-Methionyl-Leucyl-Phenylalanine) Nanocarriers for Improving HIV Drug Delivery | Li Wan, Shahriar Pooyan, Peidi Hu, Michael J. Leibowitz and Stanley Stein, et al. |
| 2120-2130 | Targeted Sialic Acid–Doxorubicin Prodrugs for Intracellular Delivery and Cancer Treatment | Sreeja Jayant, Jayant J. Khandare, Yang Wang, Ajay P. Singh and Nicholi Vorsa, et al. |
| 2131-2137 | Protective Effect of Coenzyme Q10-loaded Liposomes on the Myocardium in Rabbits with an Acute Experimental Myocardial Infarction | Daya D. Verma, William C. Hartner, Vineet Thakkar, Tatyana S. Levchenko and Vladimir P. Torchilin |
| 2138-2145 | Endocytosis and Interaction of Poly (Amidoamine) Dendrimers with Caco-2 Cells | Kelly M. Kitchens, Amy B. Foraker, Rohit B. Kolhatkar, Peter W. Swaan and Hamidreza Ghandehari |
| 2146-2155 | Signal Sequences for Targeting of Gene Therapy Products to Subcellular Compartments: The Role Of CRM1 in Nucleocytoplasmic Shuttling of the Protein Switch | Mudit Kakar, Amy B. Cadwallader, James R. Davis and Carol S. Lim |
| 2156-2167 | Rapid Doxorubicin Efflux from the Nucleus of Drug-Resistant Cancer Cells Following Extracellular Drug Clearance | Vivien Y. Chen, Maria M. Posada, Lili Zhao and Gus R. Rosania |
| 2168-2169 | AAPS Update
|
| 2171-2186 | An In Silico Transwell Device for the Study of Drug Transport and Drug–Drug Interactions | Lana X. Garmire, David G. Garmire and C. Anthony Hunt |
| 2187-2197 | Conditional Weighted Residuals (CWRES): A Model Diagnostic for the FOCE Method | Andrew C. Hooker, Christine E. Staatz and Mats O. Karlsson |
| 2198-2206 | Alginate/Chitosan Nanoparticles are Effective for Oral Insulin Delivery | B. Sarmento, A. Ribeiro, F. Veiga, P. Sampaio and R. Neufeld, et al. |
| 2207-2212 | Nail Swelling as a Pre-formulation Screen for the Selection and Optimisation of Ungual Penetration Enhancers | R. H. Khengar, S. A. Jones, R. B. Turner, B. Forbes and M. B. Brown |
| 2213-2222 | Novel Biocompatible Cationic Copolymers Based on Polyaspartylhydrazide Being Potent as Gene Vector on Tumor Cells | Manfred Ogris, Arun K. Kotha, Nicole Tietze, Ernst Wagner and Fabio Salvatore Palumbo, et al. |
| 2223-2230 | Enhanced Oromucosal Delivery of Progesterone Via Hexosomes | Nitin K. Swarnakar, Vikas Jain, Vaibhav Dubey, Dinesh Mishra and N.K. Jain |
| 2231-2238 | Effects of Methylprednisolone and Its Liver-Targeted Dextran Prodrug on Ischemia–Reperfusion Injury in a Rat Liver Transplantation Model | Anjaneya P. Chimalakonda and Reza Mehvar |
| 2239-2248 | Preclinical and Clinical In Vitro In Vivo Correlation of an hGH Dextran Microsphere Formulation | K. D. F. Vlugt-Wensink, R. de Vrueh, M. G. Gresnigt, C. M. Hoogerbrugge and S. C. van Buul-Offers, et al. |
| 2249-2262 | Computational Models to Assign Biopharmaceutics Drug Disposition Classification from Molecular Structure | Akash Khandelwal, Praveen M. Bahadduri, Cheng Chang, James E. Polli and Peter W. Swaan, et al. |
| 2263-2269 | Microencapsulation of PEGylated Adenovirus within PLGA Microspheres for Enhanced Stability and Gene Transfection Efficiency | Hyejung Mok, Ji Won Park and Tae Gwan Park |
| 2270-2280 | Stability in Plasmas of Various Species of HPMA Copolymer–PGE1 Conjugates | Huaizhong Pan, Pavla Kopečková, Jihua Liu, Dong Wang and Scott C. Miller, et al. |
| 2281-2296 | Multichannel Liquid Chromatography–Tandem Mass Spectrometry Cocktail Method for Comprehensive Substrate Characterization of Multidrug Resistance-Associated Protein 4 Transporter | Yasuo Uchida, Junichi Kamiie, Sumio Ohtsuki and Tetsuya Terasaki |
| 2297-2308 | Development of a Cell Transducible RhoA Inhibitor TAT-C3 Transferase and its Encapsulation in Biocompatible Microspheres to Promote Survival and Enhance Regeneration of Severed Neurons | Elaine Y. M. Tan, Janice W. S. Law, Chi-Hwa Wang and Alan Y. W. Lee |
| 2309-2316 | Intravenous siRNA of Brain Cancer with Receptor Targeting and Avidin–Biotin Technology | Chun-Fang Xia, Yufeng Zhang, Yun Zhang, Ruben J. Boado and William M. Pardridge |
| 2317-2326 | Enhancement of the Solubility and Efficacy of Poorly Water-Soluble Drugs by Hydrophobically-Modified Polysaccharide Derivatives | Widad Henni-Silhadi, Michel Deyme, Marie-Martine Boissonnade, Martine Appel and Didier Le Cerf, et al. |
| 2327-2332 | Hepatocyte Nuclear Factor 1 Alpha is a Factor Responsible for the Interindividual Variation of OATP1B1 mRNA Levels in Adult Japanese Livers | Tomomi Furihata, Tomomi Satoh, Naoko Yamamoto, Kaoru Kobayashi and Kan Chiba |
| 2333-2334 | Nanocarriers | Vladimir P. Torchilin |
| 2335-2352 | Multifunctional Nanorods for Biomedical Applications | Megan E. Pearce, Jessica B. Melanko and Aliasger K. Salem |
| 2353-2369 | Multifunctional Nanoparticulate Polyelectrolyte Complexes | Sean M. Hartig, Rachel R. Greene, Mikhail M. Dikov, Ales Prokop and Jeffrey M. Davidson |
| 2370-2380 | Chemical Groups that Adhere to the Surfaces of Living Malignant Cells | Cathy E. McNamee, Yuki Aso, Shinpei Yamamoto, Yoshinobu Fukumori and Hideki Ichikawa, et al. |
| 2381-2393 | One-Step Surface Modification of Poly(lactide-co-glycolide) Microparticles with Heparin | Chengji Cui and Steven P. Schwendeman |
| 2394-2401 | Effect of Liposome Characteristics and Dose on the Pharmacokinetics of Liposomes Coated with Poly(amino acid)s | Birgit Romberg, Christien Oussoren, Cor J. Snel, Wim E. Hennink and Gert Storm |
| 2402-2411 | Antitumor Effect of Paclitaxel-Loaded PEGylated Immunoliposomes Against Human Breast Cancer Cells | Tao Yang, Min-Koo Choi, Fu-De Cui, Seung-Jin Lee and Suk-Jae Chung, et al. |
| 2412-2413 | AAPS Update
|
| 249-258 | Matrix Metalloproteinase Gene Delivery for Liver Fibrosis | Yuji Iimuro and David A. Brenner |
| 259-267 | Effects of Excipients on Protein Conformation in Lyophilized Solids by Hydrogen/Deuterium Exchange Mass Spectrometry | Yunsong Li, Todd D. Williams and Elizabeth M. Topp |
| 268-276 | Combination Therapy of Heparin–Deoxycholic Acid Conjugate and Doxorubicin against Squamous Cell Carcinoma and B16F10 Melanoma | Kyeongsoon Park, Gee Young Lee, Rang-Woon Park, In-San Kim and Sang Yoon Kim, et al. |
| 277-288 | Effect of Relative Humidity on the Electrostatic Charge Properties of Dry Powder Inhaler Aerosols | Philip Chi Lip Kwok and Hak-Kim Chan |
| 289-301 | Core–shell Particles for the Dispersion of Small Polar Drugs and Biomolecules in Hydrofluoroalkane Propellants | Libo Wu, Balaji Bharatwaj, Jayanth Panyam and Sandro R. P. da Rocha |
| 302-312 | Effects of Vial Packing Density on Drying Rate during Freeze-drying of Carbohydrates or a Model Protein Measured using a Vial-weighing Technique | Henning Gieseler and Geoffrey Lee |
| 313-319 | Novel Lipid and Preservative-free Propofol Formulation: Properties and Pharmacodynamics | François Ravenelle, Sandra Gori, Dorothée Le Garrec, David Lessard and Laibin Luo, et al. |
| 320-336 | Velocity Distribution and Shear Rate Variability Resulting from Changes in the Impeller Location in the USP Dissolution Testing Apparatus II | Ge Bai and Piero M. Armenante |
| 337-348 | An Investigation into the Dispersion Mechanisms of Ternary Dry Powder Inhaler Formulations by the Quantification of Interparticulate Forces | Matthew D. Jones, Jennifer C. Hooton, Michelle L. Dawson, Alan R. Ferrie and Robert Price |
| 349-358 | Synergic Effects of Polymeric Additives on Dissolution and Crystallization of Acetaminophen | Hong Wen, Kenneth R. Morris and Kinam Park |
| 359-368 | Population Pharmacokinetic Data Analysis of Cilobradine, an If Channel Blocker | Gabriele Fliss, Alexander Staab, Christiane Tillmann, Dirk Trommeshauser and Hans G. Schaefer, et al. |
| 369-378 | Pharmacodynamics of Recombinant Human Erythropoietin in Murine Bone Marrow | Peter J. Bugelski, Thomas Nesspor, Amy Volk, Joanne O’Brien and Dorie Makropoulos, et al. |
| 379-386 | The Metastatic Stage-dependent Mucosal Expression of Sialic Acid is a Potential Marker for Targeting Colon Cancer with Cationic Polymers | Abdel Kareem Azab, Jackie Kleinstern, Morris Srebnik and Abraham Rubinstein |
| 387-399 | Synergistic Effects of a Combination of Dietary Factors Sulforaphane and (−) Epigallocatechin-3-gallate in HT-29 AP-1 Human Colon Carcinoma Cells | Sujit Nair, Vidya Hebbar, Guoxiang Shen, Avantika Gopalakrishnan and Tin Oo Khor, et al. |
| 400-406 | Lysosomal Enzyme Replacement of the Brain with Intravenous Non-Viral Gene Transfer | Yun Zhang, Yuntao Wang, Ruben J. Boado and William M. Pardridge |
| 407-416 | Gene Delivery to the Epidermal Cells of Human Skin Explants Using Microfabricated Microneedles and Hydrogel Formulations | Marc Pearton, Chris Allender, Keith Brain, Alexander Anstey and Chris Gateley, et al. |
| 417-427 | Decreased Biosynthesis of Lung Surfactant Constituent Phosphatidylcholine Due to Inhibition of Choline Transporter by Gefitinib in Lung Alveolar Cells | Naoki Ishiguro, Masanobu Oyabu, Toshihiro Sato, Tomoji Maeda and Hironobu Minami, et al. |
| 428-434 | Anti-tumor Effect of All-Trans Retinoic Acid Loaded Polymeric Micelles in Solid Tumor Bearing Mice | Narin Chansri, Shigeru Kawakami, Masayuki Yokoyama, Tatsuhiro Yamamoto and Pensri Charoensit, et al. |
| 435-440 | Novel Beads Made of Alpha-cyclodextrin and Oil for Topical Delivery of a Lipophilic Drug | Laury Trichard, M. Begoña Delgado-Charro, Richard H. Guy, Elias Fattal and Amélie Bochot |
| 441-443 | Membrane Transporters in Drug Disposition | Guofeng You |
| 444-452 | Hormonal Regulation of BCRP Expression in Human Placental BeWo Cells | Honggang Wang, Jashvant D. Unadkat and Qingcheng Mao |
| 453-462 | Impaired Clearance of Methotrexate in Organic Anion Transporter 3 (| 463-474 | Membrane Trafficking of the Human Organic Anion-Transporting Polypeptide C (hOATPC) | An-Qiang Sun, Vijaya M. Ponamgi, James L. Boyer and Frederick J. Suchy |
| 475-480 | Comparison of the Interaction of Human Organic Anion Transporter hOAT4 with PDZ Proteins between Kidney Cells and Placental Cells | Fanfan Zhou, Wen Xu, Kunihiko Tanaka and Guofeng You |
| 481-482 | AAPS Update
| |
| 1967-1990 | Preparation of Active Proteins, Vaccines and Pharmaceuticals as Fine Powders using Supercritical or Near-Critical Fluids | Stephen P. Cape, Joseph A. Villa, Edward T. S. Huang, Tzung-Horng Yang and John F. Carpenter, et al. |
| 1991-2001 | Cyclooxygenase Inhibitors Down Regulate P-glycoprotein in Human Colorectal Caco-2 Cell Line | Afraa Zrieki, Robert Farinotti and Marion Buyse |
| 2002-2011 | Contrast-Enhanced MRI-Guided Photodynamic Cancer Therapy with a Pegylated Bifunctional Polymer Conjugate | Anagha Vaidya, Yongen Sun, Yi Feng, Lyska Emerson and Eun-Kee Jeong, et al. |
| 2012-2018 | Production of Ultrafine Sumatriptan Succinate Particles for Pulmonary Delivery | Zong-Yang Yang, Yuan Le, Ting-Ting Hu, Zhigang Shen and Jian-Feng Chen, et al. |
| 2019-2029 | A Novel Nanocapsule Delivery System to Overcome Intestinal Degradation and Drug Transport Limited Absorption of P-glycoprotein Substrate Drugs | Taher Nassar, Alona Rom, Abraham Nyska and Simon Benita |
| 2030-2040 | ATR/Raman and Fractal Characterization of HPBCD/Progesterone Complex Solid Particles | Adamo Fini, Francesca Ospitali, Giorgio Zoppetti and Nadia Puppini |
| 2041-2052 | Acidic Microclimate pH Distribution in PLGA Microspheres Monitored by Confocal Laser Scanning Microscopy | Amy G. Ding and Steven P. Schwendeman |
| 2053-2055 | Editorial for Theme Section on Polymeric Micelles for Drug Delivery | Glen S. Kwon |
| 2056-2064 | Combination Antifungal Therapy Involving Amphotericin B, Rapamycin and 5-Fluorocytosine Using PEG-Phospholipid Micelles | Ronak Vakil, Kayla Knilans, David Andes and Glen S. Kwon |
| 2065-2073 | Photocytotoxicity of mTHPC (Temoporfin) Loaded Polymeric Micelles Mediated by Lipase Catalyzed Degradation | Jan-Willem Hofman, Myrra G. Carstens, Femke van Zeeland, Conny Helwig and Frits M. Flesch, et al. |
| 2074-2082 | Doxorubicin Loaded pH-sensitive Micelle: Antitumoral Efficacy against Ovarian A2780/DOXR Tumor | Dongin Kim, Eun Seong Lee, Kyeongsoon Park, Ick Chan Kwon and You Han Bae |
| 2083-2093 | Characterization of Polyion Complex Micelles Designed to Address the Challenges of Oligonucleotide Delivery | Marie-Hélène Dufresne, Mahmoud Elsabahy and Jean-Christophe Leroux |
| 2094-2096 | Theme Section on Cancer Chemoprevention | Ah-Ng Tony Kong |
| 2097-2116 | Cancer is a Preventable Disease that Requires Major Lifestyle Changes | Preetha Anand, Ajaikumar B. Kunnumakara, Chitra Sundaram, Kuzhuvelil B. Harikumar and Sheeja T. Tharakan, et al. |
| 2117-2124 | Chemoprevention of Pancreatic Cancer: Characterization of Par-4 and its Modulation by 3,3′ Diindolylmethane (DIM) | Asfar Sohail Azmi, Aamir Ahmad, Sanjeev Banerjee, Vivek M. Rangnekar and Ramzi M. Mohammad, et al. |
| 2125-2134 | Carnosol, a Dietary Diterpene, Displays Growth Inhibitory Effects in Human Prostate Cancer PC3 Cells Leading to G2-Phase Cell Cycle Arrest and Targets the 5′-AMP-Activated Protein Kinase (AMPK) Pathway | Jeremy J. Johnson, Deeba N. Syed, Chenelle R. Heren, Yewseok Suh and Vaqar M. Adhami, et al. |
| 2135-2142 | Suppression of NFκB and its Regulated Gene Products by Oral Administration of Green Tea Polyphenols in an Autochthonous Mouse Prostate Cancer Model | Imtiaz A. Siddiqui, Yogeshwer Shukla, Vaqar M. Adhami, Sami Sarfaraz and Mohammad Asim, et al. |
| 2143-2150 | Silibinin Impairs Constitutively Active TGFα-EGFR Autocrine Loop in Advanced Human Prostate Carcinoma Cells | Alpna Tyagi, Yogesh Sharma, Chapla Agarwal and Rajesh Agarwal |
| 2151-2157 | Chemoprevention of Colon Carcinogenesis by Oleanolic Acid and Its Analog in Male F344 Rats and Modulation of COX-2 and Apoptosis in Human Colon HT-29 Cancer Cells | Naveena B. Janakiram, Cooma Indranie, Swamy V. Malisetty, Patlolla Jagan and Vernon E. Steele, et al. |
| 2158-2163 | Biochanin A Inhibits Breast Cancer Tumor Growth in A Murine Xenograft Model | Young Jin Moon, Beom Soo Shin, Guohua An and Marilyn E. Morris |
| 2164-2170 | Structure–Activity Relationships and Organ Specificity in the Induction of GST and NQO1 by Alkyl-Aryl Isothiocyanates | Rex Munday, Yuesheng Zhang, Christine M. Munday, Meghana V. Bapardekar and Joseph D. Paonessa |
| 2171-2180 | Plumbagin-induced Apoptosis in Human Prostate Cancer Cells is Associated with Modulation of Cellular Redox Status and Generation of Reactive Oxygen Species | Anna A. Powolny and Shivendra V. Singh |
| 2181-2189 | Murine Prostate Cancer Inhibition by Dietary Phytochemicals—Curcumin and Phenyethylisothiocyanate | Avantika Barve, Tin Oo Khor, Xingpei Hao, Young-Sam Keum and Chung S. Yang, et al. |
| 2190-2199 | Intestinal Absorption Mechanisms of Prenylated Flavonoids Present in the Heat-Processed | 2200 | Cancer is a Preventable Disease that Requires Major Lifestyle Changes | Preetha Anand, Ajaikumar B. Kunnumakkara, Chitra Sundaram, Kuzhuvelil B. Harikumar and Sheeja T. Tharakan, et al. |
| 2201-2202 | AAPS Update
| |
| 1289-1302 | The Science of USP 1 and 2 Dissolution: Present Challenges and Future Relevance | Vivian Gray, Gregg Kelly, Min Xia, Chris Butler and Saji Thomas, et al. |
| 1303-1314 | Immunological Risk of Injectable Drug Delivery Systems | Wim Jiskoot, Rianne M. F. van Schie, Myrra G. Carstens and Huub Schellekens |
| 1315-1323 | Properties Influencing the Relative Binding Affinity of Pteroate Derivatives and Drug Conjugates Thereof to the Folate Receptor | Christopher P. Leamon, Fei You, Hari Krishna Santhapuram, Mingjin Fan and Iontcho R. Vlahov |
| 1324-1331 | Biodegradable Nanoparticles Improve Oral Bioavailability of Amphotericin B and Show Reduced Nephrotoxicity Compared to Intravenous Fungizone® | J. L. Italia, M. M. Yahya, D. Singh and M. N. V. Ravi Kumar |
| 1332-1343 | Accurate Potentiometric Determination of Lipid Membrane–Water Partition Coefficients and Apparent Dissociation Constants of Ionizable Drugs: Electrostatic Corrections | Mustafa M. A. Elsayed, Ulrich Vierl and Gregor Cevc |
| 1344-1352 | Reservoir Based Fentanyl Transdermal Drug Delivery Systems: Effect of Patch Age on Drug Release and Skin Permeation | Suneela Prodduturi, Glen J. Smith, Anna M. Wokovich, William H. Doub and Benjamin J. Westenberger, et al. |
| 1353-1364 | Physicochemical and Immunological Characterization of N,N,N-Trimethyl Chitosan-Coated Whole Inactivated Influenza Virus Vaccine for Intranasal Administration | Niels Hagenaars, Enrico Mastrobattista, Rolf J. Verheul, Imke Mooren and Harrie L. Glansbeek, et al. |
| 1365-1370 | Manufacturing Nanosized Fenofibrate by Salt Assisted Milling | Vadym N. Mochalin, Adarsh Sagar, Shruti Gour and Yury Gogotsi |
| 1371-1378 | Microspheres with Ultrahigh Holmium Content for Radioablation of Malignancies | W. Bult, P. R. Seevinck, G. C. Krijger, T. Visser and L. M. J. Kroon-Batenburg, et al. |
| 1379-1397 | The Role of Corneocytes in Skin Transport Revised—A Combined Computational and Experimental Approach | Steffi Hansen, Arne Naegel, Michael Heisig, Gabriel Wittum and Dirk Neumann, et al. |
| 1398-1406 | A Novel Hydrophilic Adhesive Matrix with Self-Enhancement for Drug Percutaneous Permeation Through Rat Skin | Jianhua Zhang, Zhipeng Liu, Hai Du, Yong Zeng and Liandong Deng, et al. |
| 1407-1418 | Targetable HPMA Copolymer–Aminohexylgeldanamycin Conjugates for Prostate Cancer Therapy | Mark P. Borgman, Abhijit Ray, Rohit B. Kolhatkar, Edward A. Sausville and Angelika M. Burger, et al. |
| 1419-1431 | Utility of Hydroxypropylmethylcellulose Acetate Succinate (HPMCAS) for Initiation and Maintenance of Drug Supersaturation in the GI Milieu | William Curatolo, James A. Nightingale and Scott M. Herbig |
| 1432-1445 | Cell Type-Specific Targeting with Surface-Engineered Lentiviral Vectors Co-displaying OKT3 Antibody and Fusogenic Molecule | Haiguang Yang, Kye-Il Joo, Leslie Ziegler and Pin Wang |
| 1446-1455 | Effects of Ionic Strength on Passive and Iontophoretic Transport of Cationic Permeant Across Human Nail | Kelly A. Smith, Jinsong Hao and S. Kevin Li |
| 1456-1466 | Postprandial Changes in Solubilizing Capacity of Human Intestinal Fluids for BCS Class II Drugs | Sarah Clarysse, Dimitrios Psachoulias, Joachim Brouwers, Jan Tack and Pieter Annaert, et al. |
| 1467-1476 | Involvement of Multidrug Resistance-Associated Protein 1 in Intestinal Toxicity of Methotrexate | Sayaka Kato, Katsuaki Ito, Yukio Kato, Tomohiko Wakayama and Yoshiyuki Kubo, et al. |
| 1477-1485 | MF59 Emulsion Is an Effective Delivery System for a Synthetic TLR4 Agonist (E6020) | Barbara C. Baudner, Vanessa Ronconi, Daniele Casini, Marco Tortoli and Jina Kazzaz, et al. |
| 1486-1495 | Intestinal Lymphatic Transport Enhances the Post-Prandial Oral Bioavailability of a Novel Cannabinoid Receptor Agonist Via Avoidance of First-Pass Metabolism | Natalie L. Trevaskis, David M. Shackleford, William N. Charman, Glenn A. Edwards and Anne Gardin, et al. |
| 1496-1503 | The Impact of Dose and Solubility of Additives on the Release from HPMC Matrix Tablets—Identifying Critical Conditions | Farhad Tajarobi, Susanna Abrahmsén-Alami, Magnus Hansen and Anette Larsson |
| 1504-1515 | A LC-MS/MS Method for the Analysis of Intracellular Nucleoside Triphosphate Levels | Ping Chen, Zhongfa Liu, Shujun Liu, Zhiliang Xie and Josephine Aimiuwu, et al. |
| 1516-1524 | Transferrin Receptor Targeted Lipopolyplexes for Delivery of Antisense Oligonucleotide G3139 in a Murine K562 Xenograft Model | Xulang Zhang, Chee Guan Koh, Bo Yu, Shujun Liu and Longzhu Piao, et al. |
| 1525-1533 | Comparing the Relative Oxidative DNA Damage Caused by Various Arsenic Species by Quantifying Urinary Levels of 8-Hydroxy-2′-Deoxyguanosine with Isotope-Dilution Liquid Chromatography/Mass Spectrometry | Jin-Zhu Wu and Paul C. Ho |
| 1534-1543 | Safety and Robustness of Coated Pellets: Self-Healing Film Properties and Storage Stability | Simon Ensslin, Klaus Peter Moll, Thomas Haefele-Racin and Karsten Mäder |
| 1544-1545 | News |
| 1547-1560 | Programmed Cell Death Pathways and Current Antitumor Targets | Mei Lan Tan, Jer Ping Ooi, Nawfal Ismail, Ahmed Ismail Hassan Moad and Tengku Sifzizul Tengku Muhammad |
| 1561-1580 | Nanoparticulate Systems for Growth Factor Delivery | Sufeng Zhang and Hasan Uludağ |
| 1581-1589 | Evaluation of Pharmacokinetics of Bioreducible Gene Delivery Vectors by Real-time PCR | Qing-Hui Zhou, Chao Wu, Devika Soundara Manickam and David Oupický |
| 1590-1595 | MDR1 Haplotypes Conferring an Increased Expression of Intestinal CYP3A4 Rather than MDR1 in Female Living-Donor Liver Transplant Patients | Keiko Hosohata, Satohiro Masuda, Atsushi Yonezawa, Toshiya Katsura and Fumitaka Oike, et al. |
| 1596-1606 | Phase Transitions in Frozen Systems and During Freeze–Drying: Quantification Using Synchrotron X-Ray Diffractometry | Dushyant B. Varshney, Prakash Sundaramurthi, Satyendra Kumar, Evgenyi Y. Shalaev and Shin-Woong Kang, et al. |
| 1607-1617 | Gastric Emptying of Pellets under Fasting Conditions: A Mathematical Model | Igor Locatelli, Aleš Mrhar and Marija Bogataj |
| 1618-1625 | Clinical Study Shows Improved Absorption of Desmopressin with Novel Formulation | Nelly Fransén, Susanne Bredenberg and Erik Björk |
| 1626-1634 | Encouraging the Move Towards Predictive Population Models for the Obese Using Propofol as a Motivating Example | Sarah C. McLeay, Glynn A. Morrish, Carl M. Kirkpatrick and Bruce Green |
| 1635-1643 | Immune Modulation by Adjuvants Combined with Diphtheria Toxoid Administered Topically in BALB/c Mice After Microneedle Array Pretreatment | Z. Ding, E. Van Riet, S. Romeijn, G. F. A. Kersten and W. Jiskoot, et al. |
| 1644-1656 | PLGA and PHBV Microsphere Formulations and Solid-State Characterization: Possible Implications for Local Delivery of Fusidic Acid for the Treatment and Prevention of Orthopaedic Infections | Chiming Yang, David Plackett, David Needham and Helen M. Burt |
| 1657-1664 | Assessment of Blood–Brain Barrier Permeability Using the In Situ Mouse Brain Perfusion Technique | Rong Zhao, J. Cory Kalvass and Gary M. Pollack |
| 1665-1678 | Inhibition Requirements of the Human Apical Sodium-Dependent Bile Acid Transporter (hASBT) Using Aminopiperidine Conjugates of glutamyl-Bile Acids | Pablo M. González, Chayan Acharya, Alexander D. MacKerell and James E. Polli |
| 1679-1688 | Towards Heat-stable Oxytocin Formulations: Analysis of Degradation Kinetics and Identification of Degradation Products | Andrea Hawe, Robert Poole, Stefan Romeijn, Piotr Kasper and Rob van der Heijden, et al. |
| 1689-1700 | Effects of Growth Conditions on the Barrier Properties of a Human Skin Equivalent | Priya Batheja, Yifan Song, Philip Wertz and Bozena Michniak-Kohn |
| 1701-1710 | Creating Functional Vesicle Assemblies from Vesicles and Nanoparticles | Robert J. Mart, Kwan Ping Liem and Simon J. Webb |
| 1711-1717 | Calcein Release from Polymeric Vesicles in Blood Plasma and PVA Hydrogel | S. Litvinchuk, Z. Lu, P. Rigler, T. D. Hirt and W. Meier |
| 1718-1728 | Diffusion Studies of Nanometer Polymersomes Across Tissue Engineered Human Oral Mucosa | Vanessa Hearnden, Hannah Lomas, Sheila MacNeil, Martin Thornhill and Craig Murdoch, et al. |
| 1729-1738 | Cellular Responses to Cancer Chemopreventive Agent D,L-Sulforaphane in Human Prostate Cancer Cells Are Initiated by Mitochondrial Reactive Oxygen Species | Dong Xiao, Anna A. Powolny, Jedrzej Antosiewicz, Eun-Ryeong Hahm and Ajay Bommareddy, et al. |
| 1739-1744 | Local and Sustained Vascular Endothelial Growth Factor Delivery for Angiogenesis Using an Injectable System | Jangwook Lee and Kuen Yong Lee |
| 1745-1751 | Effect of Tape Stripping and Adjuvants on Immune Response After Intradermal DNA Electroporation | Gaëlle Vandermeulen, Liévin Daugimont, Hervé Richiardi, Marie-Lise Vanderhaeghen and Nathalie Lecouturier, et al. |
| 1752-1763 | Combination Chemotherapeutic Dry Powder Aerosols via Controlled Nanoparticle Agglomeration | Nashwa El-Gendy and Cory Berkland |
| 1764-1775 | Nanoparticle Coated Submicron Emulsions: Sustained In-vitro Release and Improved Dermal Delivery of All-trans-retinol | Nasrin Ghouchi Eskandar, Spomenka Simovic and Clive A. Prestidge |
| 1776-1784 | Cytotoxicity of Paclitaxel Incorporated in PLGA Nanoparticles on Hypoxic Human Tumor Cells | Cheng Jin, Ling Bai, Hong Wu, Wenjie Song and Guozhen Guo, et al. |
| 1785-1791 | Efflux Protein Expression in Human Retinal Pigment Epithelium Cell Lines | Eliisa Mannermaa, Kati-Sisko Vellonen, Tuomas Ryhänen, Katriina Kokkonen and Veli-Pekka Ranta, et al. |
| 1792-1800 | Synthesis of Prostaglandin E1 Phosphate Derivatives and Their Encapsulation in Biodegradable Nanoparticles | Miho Takeda, Taishi Maeda, Tsutomu Ishihara, Haruka Sakamoto and Kanae Yuki, et al. |
| 1801-1802 | News |
| 1803-1806 | Delivered Dose: A Drug-centric Phenotype for Chemotherapy Dose Individualization | Y. Bruce Yu |
| 1807-1815 | Elucidating the ‘Jekyll and Hyde’ Nature of PXR: The Case for Discovering Antagonists or Allosteric Antagonists | Arunima Biswas, Sridhar Mani, Matthew R. Redinbo, Matthew D. Krasowski and Hao Li, et al. |
| 1816-1831 | Identification of Novel Specific and General Inhibitors of the Three Major Human ATP-Binding Cassette Transporters P-gp, BCRP and MRP2 Among Registered Drugs | Pär Matsson, Jenny M. Pedersen, Ulf Norinder, Christel A. S. Bergström and Per Artursson |
| 1832-1837 | Effect of Co-administration of Tacrolimus on the Pharmacokinetics of Multiple Subcutaneous Administered Interferon-Alpha in Rats | Hiroyuki Yamazaki, Masateru Miyake, Toru Nishibayashi, Tadashi Mukai and Masaaki Odomi, et al. |
| 1838-1846 | Local Controlled Delivery of Anti-Neoplastic RNAse to the Brain | Joram Slager, Betty Tyler, Ariella Shikanov, Abraham J. Domb and Kuslima Shogen, et al. |
| 1847-1855 | Formulation and Pharmacokinetics of Self-Assembled Rifampicin Nanoparticle Systems for Pulmonary Delivery | Jean C. Sung, Danielle J. Padilla, Lucila Garcia-Contreras, Jarod L. VerBerkmoes and David Durbin, et al. |
| 1856-1862 | Development of Multi-Phase Emulsions Based on Bioresorbable Polymers and Oily Adjuvant | Ming-Hsi Huang, Chiung-Yi Huang, Shu-Pei Lien, Syuan-Yi Siao and Ai-Hsiang Chou, et al. |
| 1863-1873 | Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling of Bidirectional Effect of Danshensu on Plasma Homocysteine in Rats | Yuancheng Chen, Yanguang Cao, Jia Zhou and Xiaoquan Liu |
| 1874-1880 | New Difluoro Knoevenagel Condensates of Curcumin, Their Schiff Bases and Copper Complexes as Proteasome Inhibitors and Apoptosis Inducers in Cancer Cells | Subhash Padhye, Huanjie Yang, Abeda Jamadar, Qiuzhi Cindy Cui and Deepak Chavan, et al. |
| 1881-1889 | Prediction of Human Bioavailability from Human Oral Administration Data and Animal Pharmacokinetic Data Without Data from Intravenous Administration of Drugs in Humans | Haruo Imawaka, Kiyomi Ito, Yoshiaki Kitamura, Kiyoshi Sugiyama and Yuichi Sugiyama |
| 1890-1900 | Novel Inhibitors of Human Organic Cation/Carnitine Transporter (hOCTN2) via Computational Modeling and In Vitro Testing | Lei Diao, Sean Ekins and James E. Polli |
| 1901-1910 | In Vitro Gastrointestinal Lipolysis of Four Formulations of Piroxicam and Cinnarizine with the Self Emulsifying Excipients Labrasol® and Gelucire® 44/14 | Sylvie Fernandez, Stéphanie Chevrier, Nicolas Ritter, Bruno Mahler and Frédéric Demarne, et al. |
| 1911-1917 | A New Minimal-Stress Freely-Moving Rat Model for Preclinical Studies on Intranasal Administration of CNS Drugs | Jasper Stevens, Ernst Suidgeest, Piet Hein van der Graaf, Meindert Danhof and Elizabeth C. M. de Lange |
| 1918-1930 | Chitosan/TPP and Chitosan/TPP-hyaluronic Acid Nanoparticles: Systematic Optimisation of the Preparative Process and Preliminary Biological Evaluation | Alessandro Nasti, Noha M. Zaki, Piero de Leonardis, Suwipa Ungphaiboon and Proramate Sansongsak, et al. |
| 1931-1941 | A Potential Targeting Gene Vector Based on Biotinylated Polyethyleneimine/Avidin Bioconjugates | Xuan Zeng, Yun-Xia Sun, Xian-Zheng Zhang, Si-Xue Cheng and Ren-Xi Zhuo |
| 1942-1951 | Integration of Preclinical and Clinical Data with Pharmacokinetic Modeling and Simulation to Evaluate Fexofenadine as a Probe for Hepatobiliary Transport Function | Brandon Swift, Xianbin Tian and Kim L. R. Brouwer |
| 1952-1962 | Semi-Mechanistic Model for Neutropenia after High Dose of Chemotherapy in Breast Cancer Patients | Amelia Ramon-Lopez, Ricardo Nalda-Molina, Belen Valenzuela and Juan Jose Perez-Ruixo |
| 1963-1973 | The In vitro Sub-cellular Localization and In vivo Efficacy of Novel Chitosan/GMO Nanostructures containing Paclitaxel | W.J. Trickler, A.A. Nagvekar and A.K. Dash |
| 1974-1985 | Skin Solubility Determines Maximum Transepidermal Flux for Similar Size Molecules | Qian Zhang, Jeffrey E. Grice, Peng Li, Owen G. Jepps and Guang-Ji Wang, et al. |
| 1986-1994 | Inhibition of Peptide Acylation in PLGA Microspheres with Water-soluble Divalent Cationic Salts | Ying Zhang, Andreas M. Sophocleous and Steven P. Schwendeman |
| 1995-2001 | Drug Delivery to the Skin From Sub-micron Polymeric Particle Formulations: Influence of Particle Size and Polymer Hydrophobicity | Xiao Wu, Bruno Biatry, Colette Cazeneuve and Richard H. Guy |
| 2002-2014 | Composite Hydrogel Formulations of Stratifin to Control MMP-1 Expression in Dermal Fibroblasts | Elham Rahmani-Neishaboor, John Jackson, Helen Burt and Aziz Ghahary |
| 2015-2026 | Role of Salt and Excipient Properties on Disproportionation in the Solid-State | Peter Guerrieri and Lynne S. Taylor |
| 2027-2036 | Investigation of Polylactic Acid (PLA) Nanoparticles as Drug Delivery Systems for Local Dermatotherapy | Fiorenza Rancan, Dimitrios Papakostas, Sabrina Hadam, Steffen Hackbarth and Thierry Delair, et al. |
| 2037-2038 | News |
| 2039-2054 | The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs | Sarah Shugarts and Leslie Z. Benet |
| 2055-2065 | Inner Blood-Retinal Barrier Transporters: Role of Retinal Drug Delivery | Ken-ichi Hosoya and Masanori Tachikawa |
| 2066-2080 | Anti-Cancer, Anti-Diabetic and Other Pharmacologic and Biological Activities of Penta-Galloyl-Glucose | Jinhui Zhang, Li Li, Sung-Hoon Kim, Ann E. Hagerman and Junxuan Lü |
| 2081-2092 | Micellar Delivery of Bicalutamide and Embelin for Treating Prostate Cancer | Michael Danquah, Feng Li, Charles B. Duke, Duane D. Miller and Ram I. Mahato |
| 2093-2100 | Powder Dissolution Method for Estimating Rotating Disk Intrinsic Dissolution Rates of Low Solubility Drugs | Konstantin Tsinman, Alex Avdeef, Oksana Tsinman and Dmytro Voloboy |
| 2101-2114 | Hydrogel Matrix Entrapping PLGA-Paclitaxel Microspheres: Drug Delivery with Near Zero-Order Release and Implantability Advantages for Malignant Brain Tumour Chemotherapy | Sudhir Hulikal Ranganath, Irene Kee, William B. Krantz, Pierce Kah-Hoe Chow and Chi-Hwa Wang |
| 2115-2124 | Drug Release Kinetics and Transport Mechanisms from Semi-interpenetrating Networks of Gelatin and Poly(ethylene glycol) diacrylate | Yao Fu and Weiyuan John Kao |
| 2125-2132 | Lactoferrin Conjugated with 40-kDa Branched Poly(ethylene Glycol) Has an Improved Circulating Half-Life | Yasuhiro Nojima, Yosuke Suzuki, Kazuhiro Yoshida, Fumiko Abe and Tuneo Shiga, et al. |
| 2133-2140 | Gallic Acid, an Active Constituent of Grape Seed Extract, Exhibits Anti-proliferative, Pro-apoptotic and Anti-tumorigenic Effects Against Prostate Carcinoma Xenograft Growth in Nude Mice | Manjinder Kaur, Balaiya Velmurugan, Subapriya Rajamanickam, Rajesh Agarwal and Chapla Agarwal |
| 2141-2151 | Characterization of the Contents of Ascending Colon to Which Drugs are Exposed After Oral Administration to Healthy Adults | Amalia Diakidou, Maria Vertzoni, Konstantinos Goumas, Erik Söderlind and Bertil Abrahamsson, et al. |
| 2152-2163 | Fabrication of a Novel Core-Shell Gene Delivery System Based on a Brush-Like Polycation of α, β–Poly (L-Aspartate-Graft-PEI) | Jia-Hui Yu, Ji-Shan Quan, Jung-Taek Kwon, Cheng-Xiong Xu and Bo Sun, et al. |
| 2164-2173 | Self-Assembled Hydrophobic Honokiol Loaded MPEG-PCL Diblock Copolymer Micelles | MaLing Gou, XiuLing Zheng, Ke Men, Juan Zhang and BiLan Wang, et al. |
| 2174-2185 | Semiparametric Distributions With Estimated Shape Parameters | Klas J. F. Petersson, Eva Hanze, Radojka M. Savic and Mats O. Karlsson |
| 2186-2193 | Stabilization of Peptide Vesicles by Introducing Inter-Peptide Disulfide Bonds | Albert J. van Hell, Daan J. A. Crommelin, Wim E. Hennink and Enrico Mastrobattista |
| 2194-2201 | An Ex Vivo Toe Model Used to Assess Applicators for the Iontophoretic Ungual Delivery of Terbinafine | Anroop B. Nair, Hyun D. Kim, Shawn P. Davis, Robert Etheredge and Michael Barsness, et al. |
| 2202-2208 | Tumor Characterization with Dynamic Contrast Enhanced Magnetic Resonance Imaging and Biodegradable Macromolecular Contrast Agents in Mice | Xueming Wu, Yi Feng, Eun-Kee Jeong, Lyska Emerson and Zheng-Rong Lu |
| 2209-2215 | Identification of the Promoter of Human Carbonyl Reductase 3 (CBR3) and Impact of Common Promoter Polymorphisms on Hepatic CBR3 mRNA Expression | Jianping Zhang and Javier G. Blanco |
| 2216-2224 | Predicting Inhibitors of Acetylcholinesterase by Regression and Classification Machine Learning Approaches with Combinations of Molecular Descriptors | Dmitriy Chekmarev, Vladyslav Kholodovych, Sandhya Kortagere, William J. Welsh and Sean Ekins |
| 2225-2226 |  |
| 2227-2236 | Pharmacokinetics and Safety in Rhesus Monkeys of a Monoclonal Antibody-GDNF Fusion Protein for Targeted Blood-Brain Barrier Delivery | William M. Pardridge and Ruben J. Boado |
| 2237-2246 | Arsonoliposomes for the Potential Treatment of Medulloblastoma | Marco E. Favretto, Showan Marouf, Panagiotis Ioannou, Sophia G. Antimisiaris and Terence L. Parker, et al. |
| 2247-2258 | Application of Screening Methods, Shape Signatures and Engineered Biosensors in Early Drug Discovery Process | Izabela Hartman, Alison R. Gillies, Sonia Arora, Christina Andaya and Nitya Royapet, et al. |
| 2259-2269 | Population Pharmacokinetic Model of the Pregabalin-Sildenafil Interaction in Rats: Application of Simulation to Preclinical PK-PD Study Design | Gregor Bender, James Gosset, Jeff Florian, Keith Tan and Mark Field, et al. |
| 2270-2279 | Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles | Tsutomu Ishihara, Miho Takeda, Haruka Sakamoto, Ayumi Kimoto and Chisa Kobayashi, et al. |
| 2280-2288 | Ginsenoside Rh2-mediated G1 Phase Cell Cycle Arrest in Human Breast Cancer Cells Is Caused by p15Ink4B and p27Kip1-dependent Inhibition of Cyclin-dependent Kinases | Sunga Choi, Tae Woong Kim and Shivendra V. Singh |
| 2289-2302 | Role of Convective Flow in Carmustine Delivery to a Brain Tumor | Davis Yohanes Arifin, Kam Yiu Timothy Lee, Chi-Hwa Wang and Kenneth A. Smith |
| 2303-2313 | A Quantitative Kinetic Study of Polysorbate Autoxidation: The Role of Unsaturated Fatty Acid Ester Substituents | Jia Yao, Dushyanth K. Dokuru, Matthew Noestheden, SungAe S. Park and Bruce A. Kerwin, et al. |
| 2314-2323 | Permeation Enhancer-Containing Water-In-Oil Nanoemulsions as Carriers for Intravesical Cisplatin Delivery | Tsong-Long Hwang, Chia-Lang Fang, Chao-Huang Chen and Jia-You Fang |
| 2324-2331 | Pharmacokinetics and Pharmacodynamics of Broccoli Sprouts on the Suppression of Prostate Cancer in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Mice: Implication of Induction of Nrf2, HO-1 and Apoptosis and the Suppression of Akt-dependent Kinase Pathway | Young-Sam Keum, Tin Oo Khor, Wen Lin, Guoxiang Shen and Ki Han Kwon, et al. |
| 2332-2342 | Novel Biodegradable Polylactide/poly(ethylene glycol) Micelles Prepared by Direct Dissolution Method for Controlled Delivery of Anticancer Drugs | Liu Yang, Xiaohan Wu, Feng Liu, Yourong Duan and Suming Li |
| 2343-2357 | Characterization of a Microsphere Formulation Containing Glucose Oxidase and its In Vivo Efficacy in a Murine Solid Tumor Model | Qun Liu, Andrew Michael Rauth, Jiang Liu, Karlo Babakhanian and Xinyue Wang, et al. |
| 2358-2366 | Mutagenesis and Cysteine Scanning of Transmembrane Domain 10 of the Human Dipeptide Transporter | Liya Xu, Ian S. Haworth, Ashutosh A. Kulkarni, Michael B. Bolger and Daryl L. Davies |
| 2367-2368 | AAPS Connection |
| 2369-2400 | At the Biological Modeling and Simulation Frontier | C. Anthony Hunt, Glen E. P. Ropella, Tai Ning Lam, Jonathan Tang and Sean H. J. Kim, et al. |
| 2401-2416 | Inhaled Drug Delivery for Tuberculosis Therapy | Pavan Muttil, Chenchen Wang and Anthony J. Hickey |
| 2417-2428 | Multivariate Analysis of the Sequence Dependence of Asparagine Deamidation Rates in Peptides | Andrew A. Kosky, Vasumathi Dharmavaram, Gayathri Ratnaswamy and Mark Cornell Manning |
| 2429-2437 | A Structural Investigation into the Compaction Behavior of Pharmaceutical Composites Using Powder X-ray Diffraction and Total Scattering Analysis | Michael D. Moore, Alison M. Steinbach, Ira S. Buckner and Peter L. D. Wildfong |
| 2438-2445 | Fluorocurcumins as Cyclooxygenase-2 Inhibitor: Molecular Docking, Pharmacokinetics and Tissue Distribution in Mice | Subhash Padhye, Sanjeev Banerjee, Deepak Chavan, Shubhangini Pandye and K.Venkateswara Swamy, et al. |
| 2446-2453 | Utility of Nanosized Microemulsion for Transdermal Delivery of Tolterodine Tartrate: Ex-Vivo Permeation and In-Vivo Pharmacokinetic Studies | Ahmed H. Elshafeey, Amany O. Kamel and Mohsen M. Fathallah |
| 2454-2463 | Demonstrated Solid-State Stability of Parathyroid Hormone PTH(1–34) Coated on a Novel Transdermal Microprojection Delivery System | Mahmoud Ameri, Peter E. Daddona and Yuh-Fun Maa |
| 2464-2470 | The Antiepileptic Drug Topiramate is a Substrate for Human P-glycoprotein but Not Multidrug Resistance Proteins | Carlos Luna-Tortós, Bernhard Rambeck, Uwe H. Jürgens and Wolfgang Löscher |
| 2471-2477 | Effects of Selective Androgen Receptor Modulator (SARM) Treatment in Osteopenic Female Rats | Jeffrey D. Kearbey, Wenqing Gao, Scott J. Fisher, Di Wu and Duane D. Miller, et al. |
| 2478-2485 | Carboxylate-Dependent Gelation of a Monoclonal Antibody | Osigwe Esue, Sonoko Kanai, Jun Liu, Thomas W. Patapoff and Steven J. Shire |
| 2486-2494 | Uptake of ANG1005, A Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer | Fancy C. Thomas, Kunal Taskar, Vinay Rudraraju, Satyanarayana Goda and Helen R. Thorsheim, et al. |
| 2495-2503 | PLGA Nanoparticles Stabilized with Cationic Surfactant: Safety Studies and Application in Oral Delivery of Paclitaxel to Treat Chemical-Induced Breast Cancer in Rat | V. Bhardwaj, D. D. Ankola, S. C. Gupta, M. Schneider and C.-M. Lehr, et al. |
| 2504-2512 | Pharmacokinetics and Efficacy of a Biweekly Dosage Formulation of Exenatide in Zucker Diabetic Fatty (ZDF) Rats | Hyun-Hee Kwak, Won-Sik Shim, Seongmee Hwang, Mi-Kyung Son and Yoon-Ji Kim, et al. |
| 2513-2522 | Microneedle Arrays Allow Lower Microbial Penetration Than Hypodermic Needles In Vitro | Ryan F. Donnelly, Thakur Raghu Raj Singh, Michael M. Tunney, Desmond I. J. Morrow and Paul A. McCarron, et al. |
| 2523-2534 | Evaluation of Drug-Polymer Miscibility in Amorphous Solid Dispersion Systems | Alfred C. F. Rumondor, Igor Ivanisevic, Simon Bates, David E. Alonzo and Lynne S. Taylor |
| 2535-2540 | “ChilDrive”: A Technique of Combining Regional Cutaneous Hypothermia with Iontophoresis for the Delivery of Drugs to Synovial Fluid | Srinivasa M. Sammeta and S. Narasimha Murthy |
| 2541-2542 | AAPS Connection |
| 2543-2550 | Physiologically-Based PK/PD Modelling of Therapeutic Macromolecules | Peter Thygesen, Panos Macheras and Achiel Van Peer |
| 2551-2557 | An Approach to the Validation of Flow Cytometry Methods | Jo Cunliffe, Nicola Derbyshire, Sue Keeler and Ruth Coldwell |
| 2558-2567 | Silibinin Suppresses Spontaneous Tumorigenesis in APCmin/+ Mouse Model by Modulating Beta-Catenin Pathway | Subapriya Rajamanickam, Manjinder Kaur, Balaiya Velmurugan, Rana P. Singh and Rajesh Agarwal |
| 2568-2577 | Poly(ethyleneglycol) 500 Dimethylether as Novel Solvent for Injectable In Situ Forming Depots | Karin Schoenhammer, Holger Petersen, Frank Guethlein and Achim Goepferich |
| 2578-2587 | Leucine-Aspartic Acid-Valine Sequence as Targeting Ligand and Drug Carrier for Doxorubicin Delivery to Melanoma Cells: In Vitro Cellular Uptake and Cytotoxicity Studies | Sha Zhong, Shiladitya Bhattacharya, William Chan, Bhaskara Jasti and Xiaoling Li |
| 2588-2598 | Preparation, Characterization and Evaluation of Targeting Potential of Amphotericin B-Loaded Engineered PLGA Nanoparticles | Manoj Nahar and Narendra K. Jain |
| 2599-2606 | Effects of Polymer Type and Storage Relative Humidity on the Kinetics of Felodipine Crystallization from Amorphous Solid Dispersions | Alfred C. F. Rumondor, Lindsay A. Stanford and Lynne S. Taylor |
| 2607-2618 | Long- and Short-Range Electrostatic Interactions Affect the Rheology of Highly Concentrated Antibody Solutions | Ravi Chari, Kavita Jerath, Advait V. Badkar and Devendra S. Kalonia |
| 2619-2629 | “Soft” Calcium Crosslinks Enable Highly Efficient Gene Transfection Using TAT Peptide | Abdulgader Baoum, Sheng-Xue Xie, Amir Fakhari and Cory Berkland |
| 2630-2638 | Reverse Iontophoresis of Amino Acids: Identification and Separation of Stratum Corneum and Subdermal Sources In Vitro | Camille C. Bouissou, Jean-Philippe Sylvestre, Richard H. Guy and M. Begoña Delgado-Charro |
| 2639-2646 | The Influence of Flow Rate on the Aerosol Deposition Profile and Electrostatic Charge of Single and Combination Metered Dose Inhalers | Susan Hoe, Daniela Traini, Hak-Kim Chan and Paul M. Young |
| 2647-2656 | Evaluation of a 99mTc-Labeled AnnexinA5 Variant for Non-invasive SPECT Imaging of Cell Death in Liver, Spleen and Prostate | Rick Greupink, Charles F. Sio, Antwan Ederveen and Joke Orsel |
| 2657-2666 | Engineering of Crystalline Combination Inhalation Particles of a Long-Acting β2-agonist and a Corticosteroid | Chonladda Pitchayajittipong, Jagdeep Shur and Robert Price |
| 2667-2676 | Antiangiogenic Activity of Orally Absorbable Heparin Derivative in Different Types of Cancer Cells | Dong Yun Lee, Sung Won Lee, Sang Kyoon Kim, Myungjin Lee and Hyo Won Chang, et al. |
| 2677-2678 | AAPS Connection  |
| 1-16 | Liquid Perfluorocarbons as Contrast Agents for Ultrasonography and 19F-MRI | Raquel Díaz-López, Nicolas Tsapis and Elias Fattal |
| 17-29 | N1,N12-Diacyl Spermines: SAR Studies on Non-viral Lipopolyamine Vectors for Plasmid DNA and siRNA Formulation | Hassan M. Ghonaim, Shi Li and Ian S. Blagbrough |
| 30-36 | Assessment of Nasal Spray Deposition Pattern in a Silicone Human Nose Model Using a Color-Based Method | Vipra Kundoor and Richard N. Dalby |
| 37-45 | Factors Affecting the Stability of Nanoemulsions—Use of Artificial Neural Networks | Amir Amani, Peter York, Henry Chrystyn and Brian J. Clark |
| 46-55 | The Targeting Behavior of Folate-Nanohydrogel Evaluated by Near Infrared Imaging System in Tumor-Bearing Mouse Model | Jian Zhang, Dawei Deng, Zhiyu Qian, Fei Liu and Xinyang Chen, et al. |
| 56-64 | Local Delivery of Ferrociphenol Lipid Nanocapsules Followed by External Radiotherapy as a Synergistic Treatment Against Intracranial 9L Glioma Xenograft | Emilie Allard, Delphine Jarnet, Anne Vessières, Sandrine Vinchon-Petit and Gérard Jaouen, et al. |
| 65-71 | Cross-Interaction Chromatography: A Rapid Method to Identify Highly Soluble Monoclonal Antibody Candidates | Steven A. Jacobs, Sheng-Jiun Wu, Yiqing Feng, Deidra Bethea and Karyn T. O’Neil |
| 72-81 | The Application of Electrostatic Dry Powder Deposition Technology to Coat Drug-Eluting Stents | Ravi Kumar Nukala, Harikrishna Boyapally, Ian J. Slipper, Andy P. Mendham and Dennis Douroumis |
| 82-91 | Using Polymer Chemistry to Modulate the Delivery of Neurotrophic Factors from Degradable Microspheres: Delivery of BDNF | James P. Bertram, Millicent F. Rauch, Kaliq Chang and Erin B. Lavik |
| 92-104 | Bioequivalence Tests Based on Individual Estimates Using Non-compartmental or Model-Based Analyses: Evaluation of Estimates of Sample Means and Type I Error for Different Designs | Anne Dubois, Sandro Gsteiger, Etienne Pigeolet and France Mentré |
| 105-114 | A Novel Gastro-Retentive Osmotic Pump Capsule Using Asymmetric Membrane Technology: In Vitro and In Vivo Evaluation | Jin Guan, Liying Zhou, Yusheng Pan, Haitao Han and Hongtao Xu, et al. |
| 115-125 | Efficiency of Fatty Acids as Chemical Penetration Enhancers: Mechanisms and Structure Enhancement Relationship | Sarah A. Ibrahim and S. Kevin Li |
| 126-133 | Positively-Charged, Porous, Polysaccharide Nanoparticles Loaded with Anionic Molecules Behave as ‘Stealth’ Cationic Nanocarriers | Archibald Paillard, Catherine Passirani, Patrick Saulnier, Maya Kroubi and Emmanuel Garcion, et al. |
| 134-142 | Mathematical Model to Predict Skin Concentration of Drugs: Toward Utilization of Silicone Membrane to Predict Skin Concentration of Drugs as an Animal Testing Alternative | Kenji Sugibayashi, Hiroaki Todo, Takeshi Oshizaka and Yoko Owada |
| 143-150 | The Pharmacokinetics of the Weakly Protein-Bound Anionic Compound Diatrizoate in Serum and Synovial Fluid of the Horse | Anna Buus Frost, Frank Larsen, Susan Weng Larsen, Jesper Østergaard and Maj Halling Thomsen, et al. |
| 151-160 | Inhalable Antibiotic Delivery Using a Dry Powder Co-delivering Recombinant Deoxyribonuclease and Ciprofloxacin for Treatment of Cystic Fibrosis | Yan Yang, Michael D. Tsifansky, Chia-Jung Wu, Hae In Yang and Gudrun Schmidt, et al. |
| 161-174 | PEGylated PAMAM Dendrimer-Doxorubicin Conjugates: In Vitro Evaluation and In Vivo Tumor Accumulation | Saijie Zhu, Minghuang Hong, Lihong Zhang, Guotao Tang and Yanyan Jiang, et al. |
| 175-186 | The Interaction Between the Oropharyngeal Geometry and Aerosols via Pressurised Metered Dose Inhalers | T. Ehtezazi, I. Saleem, I. Shrubb, D. R. Allanson and I. D. Jenkinson, et al. |
| 187-199 | Porphyrin and Galactosyl Conjugated Micelles for Targeting Photodynamic Therapy | De-Qun Wu, Ze-Yong Li, Cao Li, Jian-Jun Fan and Bo Lu, et al. |
| 200-208 | Preclinical Evaluation of Linear HPMA-Doxorubicin Conjugates with pH-Sensitive Drug Release: Efficacy, Safety, and Immunomodulating Activity in Murine Model | Milada Sirova, Tomas Mrkvan, Tomas Etrych, Petr Chytil and Pavel Rossmann, et al. |
| 209-210 | News |
| 211-223 | Mucosal Vaccines: Recent Progress in Understanding the Natural Barriers | Olga Borges, Filipa Lebre, Dulce Bento, Gerrit Borchard and Hans E. Junginger |
| 224-234 | Rational Design of Multiple TB Antigens TB10.4 and TB10.4-Ag85B as Subunit Vaccine Candidates Against Mycobacterium Tuberculosis | Shuai Shi, Lan Yu, Dengyun Sun, Jian Liu and Anthony J. Hickey |
| 235-245 | Kaempferol Suppresses Cisplatin-Induced Apoptosis Via Inductions of Heme Oxygenase-1 and Glutamate-Cysteine Ligase Catalytic Subunit in HEI-OC1 cells | Shang Shang Gao, Byung-Min Choi, Xiao Yan Chen, Ri Zhe Zhu and Youngho Kim, et al. |
| 246-258 | Hydrodynamic and Species Transfer Simulations in the USP 4 Dissolution Apparatus: Considerations for Dissolution in a Low Velocity Pulsing Flow | Deirdre M. D’Arcy, Bo Liu, Geoff Bradley, Anne Marie Healy and Owen I. Corrigan |
| 259-263 | Bifunctional Polymeric Inhibitors of Human Influenza A Viruses | Jayanta Haldar, Luis Álvarez de Cienfuegos, Terrence M. Tumpey, Larisa V. Gubareva and Jianzhu Chen, et al. |
| 264-271 | Sustained Release of Multiple Growth Factors from Injectable Polymeric System as a Novel Therapeutic Approach Towards Angiogenesis | Qinghua Sun, Eduardo A Silva, Aixia Wang, James C. Fritton and David J. Mooney, et al. |
| 272-284 | Thermosensitive Drug Delivery System of Salmon Calcitonin: In Vitro Release, In Vivo Absorption, Bioactivity and Therapeutic Efficacies | Yu Tang and Jagdish Singh |
| 285-295 | Bioactive Long-Term Release from Biodegradable Microspheres Preserves Implanted ALG-PLO-ALG Microcapsules from In Vivo Response to Purified Alginate | Stefano Giovagnoli, Paolo Blasi, Giovanni Luca, Francesca Fallarino and Mario Calvitti, et al. |
| 296-302 | Accelerated Blood Clearance Was Not Induced for a Gadolinium-Containing PEG-poly(L-lysine)-Based Polymeric Micelle in Mice | Huili Ma, Kouichi Shiraishi, Takuya Minowa, Kumi Kawano and Masayuki Yokoyama, et al. |
| 303-313 | Parathyroid Hormone PTH(1-34) Formulation that Enables Uniform Coating on a Novel Transdermal Microprojection Delivery System | Mahmoud Ameri, Shelley C. Fan and Yuh-Fun Maa |
| 314-326 | Fluorescent Molecular Rotors as Dyes to Characterize Polysorbate-Containing IgG Formulations | Andrea Hawe, Vasco Filipe and Wim Jiskoot |
| 327-339 | Therapeutic Potential of New 4-hydroxy-tamoxifen-Loaded pH-gradient Liposomes in a Multiple Myeloma Experimental Model | Giorgia Urbinati, Davide Audisio, Véronique Marsaud, Vincent Plassat and Silvia Arpicco, et al. |
| 340-349 | Population In Vitro-In Vivo Correlation Model for Pramipexole Slow-Release Oral Formulations | Elena Soto, Sebastian Haertter, Michael Koenen-Bergmann, Alexander Staab and Iñaki F. Trocóniz |
| 350-360 | PLGA Microparticles in Respirable Sizes Enhance an In Vitro T Cell Response to Recombinant Mycobacterium Tuberculosis Antigen TB10.4-Ag85B | Shuai Shi and Anthony J. Hickey |
| 361-370 | Pegylated Phospholipids-Based Self-Assembly with Water-Soluble Drugs | Yiguang Wang, Ruiqi Wang, Xiaoyan Lu, Wanliang Lu and Chunling Zhang, et al. |
| 371-379 | Improved Lysozyme Stability and Release Properties of Poly(lactide-co-glycolide) Implants Prepared by Hot-Melt Extrusion | Zahra Ghalanbor, Martin Körber and Roland Bodmeier |
| 380-389 | The Use of Amino Acid Linkers in the Conjugation of Paclitaxel with Hyaluronic Acid as Drug Delivery System: Synthesis, Self-Assembled Property, Drug Release, and In Vitro Efficiency | Dingcheng Xin, Ying Wang and Jiannan Xiang |
| 390-391 | AAPS Connection |
| 393-395 | Reaching Out to Collaborators: Crowdsourcing for Pharmaceutical Research | Sean Ekins and Antony J. Williams |
| 396-399 | The Pharmaceutical Sciences in 2020: Report of a Conference Organized by the Board of Pharmaceutical Sciences of the International Pharmaceutical Federation (FIP) | Vinod P. Shah, Luc J. R. Besancon, Pieter Stolk, Geoffrey Tucker and Daan J. A. Crommelin |
| 400-420 | Pseudovirions as Vehicles for the Delivery of siRNA | Paul E. Lund, Ryan C. Hunt, Michael M. Gottesman and Chava Kimchi-Sarfaty |
| 421-430 | Toxicological Study and Efficacy of Blank and Paclitaxel-Loaded Lipid Nanocapsules After i.v. Administration in Mice | José Hureaux, Frédéric Lagarce, Frédéric Gagnadoux, Marie-Christine Rousselet and Valérie Moal, et al. |
| 431-441 | A Semi-physiological-Based Pharmacokinetic/Pharmacodynamic Model to Describe the Effects of Topotecan on B-Lymphocyte Lineage Cells | Nieves Vélez de Mendizábal, Iván Martínez-Forero, María J. Garrido, Eva Bandrés and Jesús García-Foncillas, et al. |
| 442-446 | Model Analysis of the Concentration-Dependent Permeability of P-gp Substrates | Tatsuhiko Tachibana, Satoshi Kitamura, Motohiro Kato, Tetsuya Mitsui and Yoshiyuki Shirasaka, et al. |
| 447-456 | Oxidation of Free L-histidine by tert-Butylhydroperoxide | Bruce D. Mason, Melissa McCracken, Edward J. Bures and Bruce A. Kerwin |
| 457-467 | Cell-Based Multiscale Computational Modeling of Small Molecule Absorption and Retention in the Lungs | Jing-yu Yu and Gus R. Rosania |
| 468-479 | Neuropilin-1 Targeting Photosensitization-Induced Early Stages of Thrombosis via Tissue Factor Release | Denise Bechet, Loraine Tirand, Béatrice Faivre, François Plénat and Corinne Bonnet, et al. |
| 480-489 | Leakiness and Size Exclusion of Paracellular Channels in Cultured Epithelial Cell Monolayers–Interlaboratory Comparison | Alex Avdeef |
| 490-497 | A Plant-Derived Hydrolysable Tannin Inhibits CFTR Chloride Channel: A Potential Treatment of Diarrhea | Nisa Wongsamitkul, Lalida Sirianant, Chatchai Muanprasat and Varanuj Chatsudthipong |
| 498-509 | New Core-Shell Nanoparticules for the Intravenous Delivery of siRNA to Experimental Thyroid Papillary Carcinoma | Henri de Martimprey, Jean-Rémi Bertrand, Claude Malvy, Patrick Couvreur and Christine Vauthier |
| 510-516 | DNA Methylation Profiles of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines | Sayaka Ichihara, Ryota Kikuchi, Hiroyuki Kusuhara, Satoki Imai and Kazuya Maeda, et al. |
| 517 | Erratum to: Movement of Heparins Across Rat Gastric Mucosa is Dependent on Molecular Weight and pH | Bita Moazed and Linda M. Hiebert |
| 518-519 | AAPS Connection |
| 521-526 | Crystalline vs. Ionic Liquid Salt Forms of Active Pharmaceutical Ingredients: A Position Paper | Jelena Stoimenovski, Douglas R. MacFarlane, Katharina Bica and Robin D. Rogers |
| 527-529 | Shape-Memory Polymers as Drug Carriers—A Multifunctional System | Christian Wischke and Andreas Lendlein |
| 530-543 | New Techniques for Drug Delivery to the Posterior Eye Segment | Esther Eljarrat-Binstock, Jacob Pe’er and Abraham J. Domb |
| 544-575 | Stability of Protein Pharmaceuticals: An Update | Mark Cornell Manning, Danny K. Chou, Brian M. Murphy, Robert W. Payne and Derrick S. Katayama |
| 576-588 | Electrospun Nanofibers in Oral Drug Delivery | Francis Ignatious, Linghong Sun, Chao-Pin Lee and John Baldoni |
| 589-596 | Regulation of Human Organic Anion Transporter 4 by Protein Kinase C and NHERF-1: Altering the Endocytosis of the Transporter | Qiang Zhang, Zui Pan and Guofeng You |
| 597-607 | Hepatic Disposition of Ximelagatran and Its Metabolites in Pig; Prediction of the Impact of Membrane Transporters Through a Simple Disposition Model | Erik Sjögren, Ulf Bredberg, Erik Allard, Björn Arvidsson and Jonas Bergquist, et al. |
| 608-618 | Understanding the Behavior of Amorphous Pharmaceutical Systems during Dissolution | David E. Alonzo, Geoff G. Z. Zhang, Deliang Zhou, Yi Gao and Lynne S. Taylor |
| 619-627 | Influence of Gallate Esterification on the Activity of Procyanidin B2 in Androgen-Dependent Human Prostate Carcinoma LNCaP Cells | Shen-Chieh Chou, Manjinder Kaur, John A. Thompson, Rajesh Agarwal and Chapla Agarwal |
| 628-643 | Formulation and In Vitro-In Vivo Evaluation of Black Raspberry Extract-Loaded PLGA/PLA Injectable Millicylindrical Implants for Sustained Delivery of Chemopreventive Anthocyanins | Kashappa Goud H. Desai, Karl F. Olsen, Susan R. Mallery, Gary D. Stoner and Steven P. Schwendeman |
| 644-654 | Characteristics of rhVEGF Release from Topical Hydrogel Formulations | Junyan A. Ji, Jun Liu, Steven J. Shire, Tim J. Kamerzell and Sung Hong, et al. |
| 655-664 | Micellar Nanocarriers: Potential Nose-to-Brain Delivery of Zolmitriptan as Novel Migraine Therapy | Ratnesh Jain, Swapna Nabar, Prajakta Dandekar and Vandana Patravale |
| 665-672 | Basolateral Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3) Facilitates Intestinal Absorption of Folates in Mouse | Yoshiaki Kitamura, Hiroyuki Kusuhara and Yuichi Sugiyama |
| 673-682 | Identification of Peptide Ligands for Targeting to the Blood-Brain Barrier | Inge van Rooy, Serpil Cakir-Tascioglu, Pierre-Olivier Couraud, Ignacio A. Romero and Babette Weksler, et al. |
| 683-698 | Dendrimeric Alkylated Polyethylenimine Nano-carriers with Acid-Cleavable Outer Cationic Shells Mediate Improved Transfection Efficiency Without Increasing Toxicity | Terry W. J. Steele and Wayne Thomas Shier |
| 699-711 | Measurement and Modeling of Diffusion Kinetics of a Lipophilic Molecule Across Rabbit Cornea | Chhavi Gupta, Anuj Chauhan, Raj Mutharasan and Sangly P. Srinivas |
| 712-721 | Prostate Cancer-Targeted Imaging Using Magnetofluorescent Polymeric Nanoparticles Functionalized with Bombesin | Chang-Moon Lee, Hwan-Jeong Jeong, Su-Jin Cheong, Eun-Mi Kim and Dong Wook Kim, et al. |
| 722-731 | Phenethyl Isothiocyanate Sensitizes Androgen-Independent Human Prostate Cancer Cells to Docetaxel-Induced Apoptosis In Vitro and In Vivo | Dong Xiao and Shivendra Vikram Singh |
| 732-733 | AAPS Connection |
| 945-949 | Current Trends in the Chemoprevention of Cancer | Fazlul H. Sarkar |
| 950-961 | Cancer Chemoprevention by Natural Products: How Far Have We Come? | Rajendra G. Mehta, Genoveva Murillo, Rajesh Naithani and Xinjian Peng |
| 962-978 | Apigenin: A Promising Molecule for Cancer Prevention | Sanjeev Shukla and Sanjay Gupta |
| 979-988 | Resveratrol Mobilizes Endogenous Copper in Human Peripheral Lymphocytes Leading to Oxidative DNA Breakage: A Putative Mechanism for Chemoprevention of Cancer | S. M. Hadi, M. F. Ullah, A. S. Azmi, A. Ahmad and U. Shamim, et al. |
| 989-998 | Modulating Polo-Like Kinase 1 as a Means for Cancer Chemoprevention | Travis L. Schmit, Mark C. Ledesma and Nihal Ahmad |
| 999-1013 | Nrf2-Keap1 Signaling as a Potential Target for Chemoprevention of Inflammation-Associated Carcinogenesis | Joydeb Kumar Kundu and Young-Joon Surh |
| 1014-1026 | Diet, MicroRNAs and Prostate Cancer | Sharanjot Saini, Shahana Majid and Rajvir Dahiya |
| 1027-1041 | Regulation of microRNAs by Natural Agents: An Emerging Field in Chemoprevention and Chemotherapy Research | Yiwei Li, Dejuan Kong, Zhiwei Wang and Fazlul H. Sarkar |
| 1042-1048 | Resveratrol and Resveratrol Analogues—Structure—Activity Relationship | Thomas Szekeres, Monika Fritzer-Szekeres, Philipp Saiko and Walter Jäger |
| 1049-1053 | Bitter Melon: Antagonist to Cancer | Pratibha Nerurkar and Ratna B. Ray |
| 1054-1060 | Nanochemoprevention by Bioactive Food Components: A Perspective | Imtiaz A. Siddiqui and Hasan Mukhtar |
| 1061-1065 | Critical Need for Clinical Trials: An Example of a Pilot Human Intervention Trial of a Mixture of Natural Agents Protecting Lymphocytes Against TNF-α Induced Activation of NF-κB | Kristin Dominiak, Jaclyn McKinney, Lance K. Heilbrun and Fazlul H. Sarkar |
| 1066-1071 | Effect of Dietary Polyphenon E and EGCG on Lung Tumorigenesis in A/J Mice | Qi Zhang, Huijing Fu, Jing Pan, Jun He and Seto Ryota, et al. |
| 1072-1079 | Diallyl Trisulfide-Induced G2/M Phase Cell Cycle Arrest in DU145 Cells Is Associated with Delayed Nuclear Translocation of Cyclin-Dependent Kinase 1 | Anna Herman-Antosiewicz, Young-Ae Kim, Su-Hyeong Kim, Dong Xiao and Shivendra V. Singh |
| 1080-1091 | Suppression of the Inflammatory Cascade is Implicated in Resveratrol Chemoprevention of Experimental Hepatocarcinogenesis | Anupam Bishayee, Abhijeet Waghray, Kendra F. Barnes, Thomas Mbimba and Deepak Bhatia, et al. |
| 1092-1102 | Dietary Grape Seed Proanthocyanidins Inhibit UVB-Induced Cyclooxygenase-2 Expression and Other Inflammatory Mediators in UVB-Exposed Skin and Skin Tumors of SKH-1 Hairless Mice | Som D. Sharma and Santosh K. Katiyar |
| 1103-1114 | Anti-Melanoma Effects of Vorinostat in Combination with Polyphenolic Antioxidant (−)-Epigallocatechin-3-Gallate (EGCG) | Minakshi Nihal, Craig T. Roelke and Gary S. Wood |
| 1115-1127 | Daidzein Effect on Hormone Refractory Prostate Cancer In Vitro and In Vivo Compared to Genistein and Soy Extract: Potentiation of Radiotherapy | Vinita Singh-Gupta, Hao Zhang, Christopher K. Yunker, Zahra Ahmad and Danielle Zwier, et al. |
| 1128-1137 | In Vitro and In Vivo Effects of Water Extract of White Cocoa Tea (Camellia ptilophylla) Against Human Prostate Cancer | Li Peng, Naghma Khan, Farrukh Afaq, Chuangxing Ye and Hasan Mukhtar |
| 1138-1145 | Multiple Berry Types Prevent N-nitrosomethylbenzylamine-Induced Esophageal Cancer in Rats | Gary D. Stoner, Li-Shu Wang, Claire Seguin, Claudio Rocha and Kristen Stoner, et al. |
| 1146-1158 | Structure-Activity Studies on Therapeutic Potential of Thymoquinone Analogs in Pancreatic Cancer | Sanjeev Banerjee, Asfar S. Azmi, Subhash Padhye, Marjit W. Singh and Jubaraj B. Baruah, et al. |
| 1159-1168 | FoxM1 is a Novel Target of a Natural Agent in Pancreatic Cancer | Zhiwei Wang, Aamir Ahmad, Sanjeev Banerjee, Asfar Azmi and Dejuan Kong, et al. |
| 1169-1170 | AAPS Connection |
| 1171-1183 | Targeting Anticancer Drugs to Tumor Vasculature Using Cationic Liposomes | Amr S. Abu Lila, Tatsuhiro Ishida and Hiroshi Kiwada |
| 1184-1202 | Drug Delivery Systems and Liver Targeting for the Improved Pharmacotherapy of the Hepatitis B Virus (HBV) Infection | María L. Cuestas, Verónica L. Mathet, José R. Oubiña and Alejandro Sosnik |
| 1203-1207 | Measurement Science for Food and Drug Monographs: Toward a Global System | William F. Koch, Walter W. Hauck, Susan S. de Mars and Roger L. Williams |
| 1208-1223 | Intranasal Delivery—Modification of Drug Metabolism and Brain Disposition | Yin Cheong Wong and Zhong Zuo |
| 1224-1236 | Nanoparticles for Local Drug Delivery to the Oral Mucosa: Proof of Principle Studies | Andrew S. Holpuch, Garrett J. Hummel, Meng Tong, Garrett A. Seghi and Ping Pei, et al. |
| 1237-1254 | Physiological Modeling to Understand the Impact of Enzymes and Transporters on Drug and Metabolite Data and Bioavailability Estimates | Huadong Sun and K. Sandy Pang |
| 1255-1263 | Rapid Sampling of Molecules via Skin for Diagnostic and Forensic Applications | Sumit Paliwal, Makoto Ogura and Samir Mitragotri |
| 1264-1272 | Novel Topical Microbicides Through Combinatorial Strategies | Anubhav Arora and Samir Mitragotri |
| 1273-1284 | siRNA Knock-Down of RANK Signaling to Control Osteoclast-Mediated Bone Resorption | Yuwei Wang and David W. Grainger |
| 1285-1295 | The Development and Mechanism Studies of Cationic Chitosan-Modified Biodegradable PLGA Nanoparticles for Efficient siRNA Drug Delivery | Xudong Yuan, Bruhal A. Shah, Naimesh K. Kotadia, Jian Li and Hua Gu, et al. |
| 1296-1308 | Effects of Single and Multiple Flavonoids on BCRP-Mediated Accumulation, Cytotoxicity and Transport of Mitoxantrone In Vitro | Guohua An and Marilyn E. Morris |
| 1309-1317 | Multivariate Data Analysis of Factors Affecting the In Vitro Dissolution Rate and the Apparent Solubility for a Model Basic Drug Substance in Aqueous Media | Anita Maria Persson, Curt Pettersson and Josefin Rosén |
| 1318-1324 | Isolation and Characterization of Cetirizine Degradation Product: Mechanism of Cetirizine Oxidation | Tatyana Dyakonov, April Muir, Hassen Nasri, Dana Toops and Aqeel Fatmi |
| 1325-1336 | The Contribution of Different Formulation Components on the Aerosol Charge in Carrier-Based Dry Powder Inhaler Systems | Susan Hoe, Daniela Traini, Hak-Kim Chan and Paul M. Young |
| 1337-1347 | The Molecular Chaperone α-Crystallin as an Excipient in an Insulin Formulation | Tue Rasmussen, Ruedeeporn Tantipolphan, Marco van de Weert and Wim Jiskoot |
| 1348-1360 | Phase Separation of an IgG1 Antibody Solution under a Low Ionic Strength Condition | Hirotaka Nishi, Makoto Miyajima, Hiroaki Nakagami, Masanori Noda and Susumu Uchiyama, et al. |
| 1361-1366 | Mechanistic Study of the Azithromycin Dosage-Form-Dependent Food Effect | William Curatolo, George Foulds and Robert LaBadie |
| 1367-1376 | Particle Aerosolisation and Break-up in Dry Powder Inhalers 1: Evaluation and Modelling of Venturi Effects for Agglomerated Systems | William Wong, David F. Fletcher, Daniela Traini, Hak-Kim Chan and John Crapper, et al. |
| 1377-1389 | Investigation of the Milling-Induced Thermal Behavior of Crystalline and Amorphous Griseofulvin | Niraj S. Trasi, Stephan X. M. Boerrigter and Stephen Robert Byrn |
| 1390-1397 | Stability and Biodistribution of a Biodegradable Macromolecular MRI Contrast Agent Gd-DTPA Cystamine Copolymers (GDCC) in Rats | Xueming Wu, Yuda Zong, Zhen Ye and Zheng-Rong Lu |
| 1398-1407 | Prediction of the Corneal Permeability of Drug-Like Compounds | Heidi Kidron, Kati-Sisko Vellonen, Eva M. del Amo, Anita Tissari and Arto Urtti |
| 1408-1415 | Liposomes Coloaded with Iopamidol/Lipiodol as a RES-Targeted Contrast Agent for Computed Tomography Imaging | Soonjae Kweon, Ho-Joon Lee, Woo Jin Hyung, Jinsuk Suh and Joon Seok Lim, et al. |
| 1416-1425 | Factors Affecting the In Vivo Lactone Stability and Systemic Clearance of the Lipophilic Camptothecin Analogue AR-67 | Eyob D. Adane, Zhiwei Liu, Tian-Xiang Xiang, Bradley D. Anderson and Markos Leggas |
| 1426-1436 | Design and Evaluation of Histidine-Rich Amphipathic Peptides for siRNA Delivery | Bérangère Langlet-Bertin, Christian Leborgne, Daniel Scherman, Burkhard Bechinger and A. James Mason, et al. |
| 1437-1438 | AAPS Connection |
| 1439-1468 | Orphan Nuclear Receptors as Targets for Drug Development | Subhajit Mukherjee and Sridhar Mani |
| 1469-1486 | Phospholipids and Lipid-Based Formulations in Oral Drug Delivery | Gert Fricker, Torsten Kromp, Armin Wendel, Alfred Blume and Jürgen Zirkel, et al. |
| 1487-1497 | Gene Therapy: A Pharmacokinetic/Pharmacodynamic Modelling Overview | Zinnia P. Parra-Guillén, Gloria González-Aseguinolaza, Pedro Berraondo and Iñaki F. Trocóniz |
| 1498-1511 | Novel Mixed Polymeric Micelles for Enhancing Delivery of Anticancer Drug and Overcoming Multidrug Resistance in Tumor Cell Lines Simultaneously | Xinru Li, Pingzhu Li, Yanhui Zhang, Yanxia Zhou and Xingwei Chen, et al. |
| 1512-1529 | Potential Aggregation-Prone Regions in Complementarity-Determining Regions of Antibodies and Their Contribution Towards Antigen Recognition: A Computational Analysis | Xiaoling Wang, Satish K. Singh and Sandeep Kumar |
| 1530-1546 | Simulating Dissolution of Intravitreal Triamcinolone Acetonide Suspensions in an Anatomically Accurate Rabbit Eye Model | Paul J. Missel, Marc Horner and R. Muralikrishnan |
| 1547-1557 | Cellular Entry of G3.5 Poly (amido amine) Dendrimers by Clathrin- and Dynamin-Dependent Endocytosis Promotes Tight Junctional Opening in Intestinal Epithelia | Deborah S. Goldberg, Hamidreza Ghandehari and Peter W. Swaan |
| 1558-1567 | Fast Surface Crystallization of Amorphous Griseofulvin Below Tg | Lei Zhu, Janan Jona, Karthik Nagapudi and Tian Wu |
| 1568-1583 | Use of Isoform-Specific UGT Metabolism to Determine and Describe Rates and Profiles of Glucuronidation of Wogonin and Oroxylin A by Human Liver and Intestinal Microsomes | Qiong Zhou, Zhijie Zheng, Bijun Xia, Lan Tang and Chang Lv, et al. |
| 1584-1596 | Mannan-Modified Solid Lipid Nanoparticles for Targeted Gene Delivery to Alveolar Macrophages | Wangyang Yu, Chunxi Liu, Yu Liu, Na Zhang and Wenfang Xu |
| 1597-1609 | Antibacterial Efficacy of Inhalable Levofloxacin-Loaded Polymeric Nanoparticles Against E. coli Biofilm Cells: The Effect of Antibiotic Release Profile | Wean Sin Cheow, Matthew Wook Chang and Kunn Hadinoto |
| 1610-1619 | High-Throughput Screening System for Identifying Phototoxic Potential of Drug Candidates Based on Derivatives of Reactive Oxygen Metabolites | Satomi Onoue, Masanori Ochi, Graham Gandy, Yoshiki Seto and Naoko Igarashi, et al. |
| 1620-1626 | Characterization of the Ascending Colon Fluids in Ulcerative Colitis | Maria Vertzoni, Konstantinos Goumas, Erik Söderlind, Bertil Abrahamsson and Jennifer B. Dressman, et al. |
| 1627-1643 | Thermosensitive Micelles from PEG-Based Ether-anhydride Triblock Copolymers | Aijun Zhao, Shaobing Zhou, Qi Zhou and Tao Chen |
| 1644-1658 | In Situ Artificial Membrane Permeation Assay under Hydrodynamic Control: Permeability-pH Profiles of Warfarin and Verapamil | Matěj Velický, Dan F. Bradley, Kin Y. Tam and Robert A. W. Dryfe |
| 1659-1676 | Development of New Localized Drug Delivery System Based on Ceftriaxone-Sulbactam Composite Drug Impregnated Porous Hydroxyapatite: A Systematic Approach for In Vitro and In Vivo Animal Trial | Biswanath Kundu, Chidambaram Soundrapandian, Samit K. Nandi, Prasenjit Mukherjee and Nandadulal Dandapat, et al. |
| 1677-1686 | Bioadhesive Films Containing Benzocaine: Correlation Between In Vitro Permeation and In Vivo Local Anesthetic Effect | Daniele Ribeiro de Araujo, Cristina Padula, Cíntia Maria Saia Cereda, Giovana Radomille Tófoli and Rui Barbosa Brito, et al. |
| 1687-1702 | Evaluation of Docetaxel-Loaded Intravenous Lipid Emulsion: Pharmacokinetics, Tissue Distribution, Antitumor Activity, Safety and Toxicity | Mingming Zhao, Min Su, Xia Lin, Yanfei Luo and Haibing He, et al. |
| 1703-1712 | Effects of Commonly Used Excipients on the Expression of CYP3A4 in Colon and Liver Cells | Leslie Tompkins, Caitlin Lynch, Sam Haidar, James Polli and Hongbing Wang |
| 1713-1721 | Novel Cyclopeptides for the Design of MMP Directed Delivery Devices: A Novel Smart Delivery Paradigm | El-Farouck Moustoifa, Mohamed-Anis Alouini, Arnaud Salaün, Thomas Berthelot and Aghleb Bartegi, et al. |
| 1722-1729 | Deposition of Albuterol Aerosol Generated by Pneumatic Nebulizer in the Sophia Anatomical Infant Nose-Throat (SAINT) Model | Beth L. Laube, Gail Sharpless, Charles Shermer, Omer Nasir and Vincent Sullivan, et al. |
| 1730-1737 | In Vitro–In Vivo Correlations of Scalable PLGA-Risperidone Implants for the Treatment of Schizophrenia | Laura C. Amann, Michael J. Gandal, Robert Lin, Yuling Liang and Steven J. Siegel |
| 1738-1745 | Chitosan Film Containing Poly(D,L-Lactic-Co-Glycolic Acid) Nanoparticles: A Platform for Localized Dual-Drug Release | Dayane B. Tada, Surinder Singh, Dattatri Nagesha, Evan Jost and Craig O. Levy, et al. |
| 1746-1749 | Application of Nanotechnology in Cosmetics | Li Mu and Robert L. Sprando |
| 1750-1754 | Hyperthermia and Thermosensitive Liposomes for Improved Delivery of Chemotherapeutic Drugs to Solid Tumors | Gerben A. Koning, Alexander M. M. Eggermont, Lars H. Lindner and Timo L. M. ten Hagen |
| 1755-1756 | AAPS Connection  |
| 1757-1758 | Publication Ethics—A Guide for Submitting Manuscripts to Pharmaceutical Research | Peter W. Swaan |
| 1759-1771 | Nanoparticle-Mediated Brain-Specific Drug Delivery, Imaging, and Diagnosis | Hu Yang |
| 1772-1787 | Use of In Vivo Animal Models to Assess Pharmacokinetic Drug-Drug Interactions | Cuyue Tang and Thomayant Prueksaritanont |
| 1788-1799 | A Direct Comparison of Anti-microRNA Oligonucleotide Potency | Kim A. Lennox and Mark A. Behlke |
| 1800-1811 | Evaluation of Enhanced Condensational Growth (ECG) for Controlled Respiratory Drug Delivery in a Mouth-Throat and Upper Tracheobronchial Model | Michael Hindle and P. Worth Longest |
| 1812-1824 | Aggregated Recombinant Human Interferon Beta Induces Antibodies but No Memory in Immune-Tolerant Transgenic Mice | Miranda M. C. van Beers, Melody Sauerborn, Francesca Gilli, Vera Brinks and Huub Schellekens, et al. |
| 1825-1836 | Relationship Between the Enhancement Effects of Chemical Permeation Enhancers on the Lipoidal Transport Pathway Across Human Skin Under the Symmetric and Asymmetric Conditions In Vitro | Doungdaw Chantasart and S. Kevin Li |
| 1837-1847 | Microneedle-Based Transcutaneous Immunisation in Mice with N-Trimethyl Chitosan Adjuvanted Diphtheria Toxoid Formulations | Suzanne M. Bal, Zhi Ding, Gideon F. A. Kersten, Wim Jiskoot and Joke A. Bouwstra |
| 1848-1860 | A Novel Doxorubicin Prodrug with Controllable Photolysis Activation for Cancer Chemotherapy | Stuart Ibsen, Eran Zahavy, Wolf Wrasdilo, Michael Berns and Michael Chan, et al. |
| 1861-1868 | Targeted Polymeric Micelle System for Delivery of Combretastatin A4 to Tumor Vasculature In Vitro | Yiguang Wang, Tingyuan Yang, Xun Wang, Jiancheng Wang and Xuan Zhang, et al. |
| 1869-1883 | Characterisation and Prediction of Phase Separation in Hot-Melt Extruded Solid Dispersions: A Thermal, Microscopic and NMR Relaxometry Study | Sheng Qi, Peter Belton, Kathrin Nollenberger, Nigel Clayden and Mike Reading, et al. |
| 1884-1892 | Dextran Gadolinium Complexes as Contrast Agents for Magnetic Resonance Imaging to Sentinel Lymph Nodes | Guo-Ping Yan, Wei Xu, Lian Yang, Liang Li and Fan Liu, et al. |
| 1893-1899 | Pharmacokinetics and Toxicodynamics of Oxaliplatin in Rats: Application of a Toxicity Factor to Explain Differences in the Nephrotoxicity and Myelosuppression Induced by Oxaliplatin and the Other Platinum Antitumor Derivatives | Kazuhiko Hanada, Makoto Suda, Norihito Kanai and Hiroyasu Ogata |
| 1900-1913 | Evaluation of Temperature-Sensitive, Indocyanine Green-Encapsulating Micelles for Noninvasive Near-Infrared Tumor Imaging | Tae Hee Kim, Yongping Chen, Christopher W. Mount, Wayne R. Gombotz and Xingde Li, et al. |
| 1914-1926 | Paclitaxel-Loaded, Folic-Acid-Targeted and TAT-Peptide-Conjugated Polymeric Liposomes: In Vitro and In Vivo Evaluation | Peiqi Zhao, Hanjie Wang, Man Yu, Shuzhen Cao and Fei Zhang, et al. |
| 1927-1938 | Bisethylnorspermine Lipopolyamine as Potential Delivery Vector for Combination Drug/Gene Anticancer Therapies | Yanmei Dong, Jing Li, Chao Wu and David Oupický |
| 1939-1948 | Chitosan-Alginate Scaffold Culture System for Hepatocellular Carcinoma Increases Malignancy and Drug Resistance | Matthew Leung, Forrest M. Kievit, Stephen J. Florczyk, Omid Veiseh and Jennifer Wu, et al. |
| 1949-1964 | The Mechanism of Lymphatic Access of Two Cholesteryl Ester Transfer Protein Inhibitors (CP524,515 and CP532,623) and Evaluation of Their Impact on Lymph Lipoprotein Profiles | Natalie L. Trevaskis, Ravi M. Shanker, William N. Charman and Christopher J. H. Porter |
| 1965-1976 | Effect of Crystal Size on the In Vitro Dissolution and Oral Absorption of Nitrendipine in Rats | Dengning Xia, Fude Cui, Hongze Piao, Dongmei Cun and Hongyu Piao, et al. |
| 1977-1986 | Inhalable Microparticles as Carriers for Pulmonary Delivery of Thymopentin-Loaded Solid Lipid Nanoparticles | Yan-Zhen Li, Xun Sun, Tao Gong, Jie Liu and Jiao Zuo, et al. |
| 1987-1998 | Evaluation of 99mTechnetium-Mebrofenin and 99mTechnetium-Sestamibi as Specific Probes for Hepatic Transport Protein Function in Rat and Human Hepatocytes | Brandon Swift, Wei Yue and Kim L. R. Brouwer |
| 1999-2007 | An Improved Nonlinear Model Describing the Hepatic Pharmacokinetics of Digoxin: Evidence for Two Functionally Different Uptake Systems and Saturable Binding | Michael Weiss, Peng Li and Michael S. Roberts |
| 2008-2017 | Hydrophilic Polyester Microspheres: Effect of Molecular Weight and Copolymer Composition on Release of BSA | Amir H. Ghassemi, Mies J. van Steenbergen, Herre Talsma, Cornelus F. van Nostrum and Daan J. A. Crommelin, et al. |
| 2018-2029 | From Drug Delivery Systems to Drug Release, Dissolution, IVIVC, BCS, BDDCS, Bioequivalence and Biowaivers | Vangelis Karalis, Eleni Magklara, Vinod P. Shah and Panos Macheras |
| 2030 | Erratum to: PEGylated PAMAM Dendrimer-Doxorubicin Conjugates: In Vitro Evaluation and In Vivo Tumor Accumulation | Saijie Zhu, Minghuang Hong, Lihong Zhang, Guotao Tang and Yanyan Jiang, et al. |
| 2031 | Erratum to: “Multiple Berry Types Prevent N-nitrosomethylbenzylamine-Induced Esophageal Cancer in Rats” | Gary D. Stoner, Li-Shu Wang, Claire Seguin, Claudio Rocha and Kristen Stoner, et al. |
| 2032-2033 | AAPS Connection |
| 2035-2039 | Chemical Space: Missing Pieces in Cheminformatics | Sean Ekins, Rishi R. Gupta, Eric Gifford, Barry A. Bunin and Chris L. Waller |
| 2040-2042 | The Mucosal Immune Response to Plant-Derived Vaccines | Kathleen Laura Hefferon |
| 2043-2053 | Biodegradable Implants for Sustained Drug Release in the Eye | Susan S. Lee, Patrick Hughes, Aron D. Ross and Michael R. Robinson |
| 2054-2062 | Vectorial Ligand Transport Through Mammalian Choroid Plexus | Reynold Spector and Conrad E. Johanson |
| 2063-2074 | Development of PLGA-Based Injectable Delivery Systems For Hydrophobic Fenretinide | Christian Wischke, Ying Zhang, Sachin Mittal and Steven P. Schwendeman |
| 2075-2084 | Hypoxia-Inducible Vascular Endothelial Growth Factor Gene Therapy Using the Oxygen-Dependent Degradation Domain in Myocardial Ischemia | Hyun Ah Kim, Soyeon Lim, Hyung-Ho Moon, Sung Wan Kim and Ki-Chul Hwang, et al. |
| 2085-2097 | Silibinin Exerts Sustained Growth Suppressive Effect against Human Colon Carcinoma SW480 Xenograft by Targeting Multiple Signaling Molecules | Balaiya Velmurugan, Subhash Chander Gangar, Manjinder Kaur, Alpna Tyagi and Gagan Deep, et al. |
| 2098-2105 | In Vivo Inhibition of BCRP/ABCG2 Mediated Transport of Nitrofurantoin by the Isoflavones Genistein and Daidzein: A Comparative Study in Bcrp1 −/− Mice | Gracia Merino, Miriam Perez, Rebeca Real, Estefania Egido and Julio G. Prieto, et al. |
| 2106-2118 | Polymethacrylate Microparticles Gel for Topical Drug Delivery | Hagar Ibrahim Labouta and Labiba K. El-Khordagui |
| 2119-2130 | Predicting Intestinal Precipitation—A Case Example for a Basic BCS Class II Drug | Sara Carlert, Anna Pålsson, Gunilla Hanisch, Christian von Corswant and Catarina Nilsson, et al. |
| 2131-2140 | Inhalation Performance of Physically Mixed Dry Powders Evaluated with a Simple Simulator for Human Inspiratory Flow Patterns | Daiki Hira, Tomoyuki Okuda, Daisuke Kito, Kazunori Ishizeki and Toyoko Okada, et al. |
| 2141-2149 | Intestinal Absorption of HMG-CoA Reductase Inhibitor Pravastatin Mediated by Organic Anion Transporting Polypeptide | Yoshiyuki Shirasaka, Kensuke Suzuki, Takeo Nakanishi and Ikumi Tamai |
| 2150-2161 | Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View | David Hallifax, Joanne A. Foster and J. Brian Houston |
| 2162-2174 | Decrease of Plasminogen Activator Inhibitor-1 May Contribute to the Anti-Invasive Action of Cannabidiol on Human Lung Cancer Cells | Robert Ramer, Anja Rohde, Jutta Merkord, Helga Rohde and Burkhard Hinz |
| 2175-2186 | Beta-casein Nanoparticles as an Oral Delivery System for Chemotherapeutic Drugs: Impact of Drug Structure and Properties on Co-assembly | Alina Shapira, Yehuda G. Assaraf, Dikla Epstein and Yoav D. Livney |
| 2187-2196 | Biorelevant Media to Simulate Fluids in the Ascending Colon of Humans and Their Usefulness in Predicting Intracolonic Drug Solubility | Maria Vertzoni, Amalia Diakidou, Manos Chatzilias, Erik Söderlind and Bertil Abrahamsson, et al. |
| 2197-2204 | Mass Spectrometric Analysis of Intact Human Monoclonal Antibody Aggregates Fractionated by Size-Exclusion Chromatography | Başak Kükrer, Vasco Filipe, Esther van Duijn, Piotr T. Kasper and Rob J. Vreeken, et al. |
| 2205-2212 | Holmium Nanoparticles: Preparation and In Vitro Characterization of a New Device for Radioablation of Solid Malignancies | Wouter Bult, Rosanne Varkevisser, Fouad Soulimani, Peter R. Seevinck and Hendrik de Leeuw, et al. |
| 2213-2220 | Microneedle Pre-treatment of Human Skin Improves 5-Aminolevulininc Acid (ALA)- and 5-Aminolevulinic Acid Methyl Ester (MAL)-Induced PpIX Production for Topical Photodynamic Therapy Without Increase in Pain or Erythema | Patrycja Mikolajewska, Ryan F. Donnelly, Martin J. Garland, Desmond I. J. Morrow and Thakur Raghu Raj Singh, et al. |
| 2221-2233 | Anisotropic Porous Structure of Pharmaceutical Compacts Evaluated by PGSTE-NMR in Relation to Mechanical Property Anisotropy | Patrice Porion, Virginie Busignies, Vincent Mazel, Bernard Leclerc and Pierre Evesque, et al. |
| 2234-2241 | Using Thermally Stimulated Current (TSC) to Investigate Disorder in Micronized Drug Substance Produced at Different Milling Energies | Rachel Forcino, Jeffrey Brum, Marc Galop and Yan Sun |
| 2242-2253 | Simultaneous Delivery of Chemotherapeutic and Thermal-Optical Agents to Cancer Cells by a Polymeric (PLGA) Nanocarrier: An In Vitro Study | Yuan Tang, Tingjun Lei, Romila Manchanda, Abhignyan Nagesetti and Alicia Fernandez-Fernandez, et al. |
| 2254-2255 | News |
| 2257-2259 | Multifunctional Polymeric Carriers for Gene and Drug Delivery | Tatiana Bronich |
| 2260-2273 | pH-Sensitive Multi-PEGylated Block Copolymer as a Bioresponsive pDNA Delivery Vector | Tsz Chung Lai, Younsoo Bae, Takayuki Yoshida, Kazunori Kataoka and Glen S. Kwon |
| 2274-2282 | Multi-component Polymeric System for Tumour Cell-Specific Gene Delivery Using a Universal Bungarotoxin Linker | Ralph A. Willemsen, Michal Pechar, Robert C. Carlisle, Erik Schooten and Robert Pola, et al. |
| 2283-2295 | PEG-Functionalized Magnetic Nanoparticles for Drug Delivery and Magnetic Resonance Imaging Applications | Murali Mohan Yallapu, Susan P. Foy, Tapan K. Jain and Vinod Labhasetwar |
| 2296-2306 | Multifunctional Tumor-Targeted Polymer-Peptide-Drug Delivery System for Treatment of Primary and Metastatic Cancers | Pooja Chandna, Jayant J. Khandare, Elizabeth Ber, Lorna Rodriguez-Rodriguez and Tamara Minko |
| 2307-2316 | PAMAM-Camptothecin Conjugate Inhibits Proliferation and Induces Nuclear Fragmentation in Colorectal Carcinoma Cells | Giridhar Thiagarajan, Abhijit Ray, Alexander Malugin and Hamidreza Ghandehari |
| 2317-2329 | Temozolomide Delivery to Tumor Cells by a Multifunctional Nano Vehicle Based on Poly(β-L-malic acid) | Rameshwar Patil, José Portilla-Arias, Hui Ding, Satoshi Inoue and Bindu Konda, et al. |
| 2330-2342 | PEG-poly(amino acid) Block Copolymer Micelles for Tunable Drug Release | Andrei Ponta and Younsoo Bae |
| 2343-2355 | In Vivo Distribution of Polymeric Nanoparticles at the Whole-Body, Tumor, and Cellular Levels | Helen Lee, Bryan Hoang, Humphrey Fonge, Raymond M. Reilly and Christine Allen |
| 2356-2364 | Triclosan-Loaded Tooth-Binding Micelles for Prevention and Treatment of Dental Biofilm | Fu Chen, Kelly C. Rice, Xin-Ming Liu, Richard A. Reinhardt and Kenneth W. Bayles, et al. |
| 2365-2373 | Old and New Molecular Mechanisms Associated with Platelet Resistance to Antithrombotics | Antonio J. López Farré, Juan Tamargo, Petra J. Mateos-Cáceres, Luís Azcona and Carlos Macaya |
| 2374-2383 | Crystallization of Trehalose in Frozen Solutions and its Phase Behavior during Drying | Prakash Sundaramurthi, Thomas W. Patapoff and Raj Suryanarayanan |
| 2384-2393 | Influence of Crystallizing and Non-crystallizing Cosolutes on Trehalose Crystallization During Freeze-Drying | Prakash Sundaramurthi and Raj Suryanarayanan |
| 2394-2401 | Nanocomposite Formulation System of Lipid-Regulating Drugs Based on Layered Double Hydroxide: Synthesis, Characterization and Drug Release Properties | Mohamed R. Berber, Inas H. Hafez, Keiji Minagawa, Takeshi Mori and Masami Tanaka |
| 2402-2413 | Leachables from Saline-Containing IV Bags Can Alter Therapeutic Protein Properties | Judy Y. Chang, Nina J. Xiao, Min Zhu, Jennifer Zhang and Ed Hoff, et al. |
| 2414-2420 | PLGA Erosion: Solubility- or Diffusion-Controlled? | Martin Körber |
| 2421-2432 | Mixed pH-Sensitive Polymeric Micelles for Combination Drug Delivery | Younsoo Bae, Adam W. G. Alani, Nicole C. Rockich, T. S. Z. Chung Lai and Glen S. Kwon |
| 2433-2445 | Reliability of Inhibition Models to Correctly Identify Type of Inhibition | Vidula Kolhatkar and James E. Polli |
| 2446-2456 | Influence of Permeant Lipophilicity on Permeation Across Human Sclera | He Wen, Jinsong Hao and S. Kevin Li |
| 2457-2465 | Effect of Serum on Transfection by Polyethylenimine/Virus-Like Particle Hybrid Gene Delivery Vectors | David M. Drake, Rahul K. Keswani and Daniel W. Pack |
| 2466-2477 | Multicomponent Amorphous Nanofibers Electrospun from Hot Aqueous Solutions of a Poorly Soluble Drug | Deng-Guang Yu, Li-Dong Gao, Kenneth White, Christopher Branford-White and Wei-Yue Lu, et al. |
| 2478-2491 | Design of a Semisolid Vaginal Microbicide Gel by Relating Composition to Properties and Performance | Alamelu Mahalingam, Eric Smith, Judit Fabian, Festo R. Damian and Jennifer J. Peters, et al. |
| 2492-2504 | Inhibition of Endogenous Hedgehog Signaling Protects Against Acute Liver Injury After Ischemia Reperfusion | Akshay Pratap, Ravikiran Panakanti, Ningning Yang, James D. Eason and Ram I. Mahato |
| 2505-2508 | Building Membrane Emulsification into Pulmonary Drug Delivery and Targeting | Decai Bao and Yanjun Zhao |
| 2509-2513 | Application of Plant Viruses as Nano Drug Delivery Systems | Yupeng Ren, Sek Man Wong and Lee Yong Lim |
| 2514-2515 | AAPS Connection |
| 2517-2519 | Polymeric Biomaterials for Gene and Drug Delivery | David Oupicky |
| 2520-2527 | Pulmonary Gene Silencing in Transgenic EGFP Mice Using Aerosolised Chitosan/siRNA Nanoparticles | Ebbe J. B. Nielsen, Jan M. Nielsen, Daniel Becker, Alexander Karlas and Hridayesh Prakash, et al. |
| 2528-2543 | Multifunctional Peptide-PEG Intercalating Conjugates: Programmatic of Gene Delivery to the Blood-Brain Barrier | Hongwei Zhang, Trevor Gerson, Michelle L. Varney, Rakesh K. Singh and Serguei V. Vinogradov |
| 2544-2555 | Hyaluronic Acid/Chitosan-g-Poly(ethylene glycol) Nanoparticles for Gene Therapy: An Application for pDNA and siRNA Delivery | Manuela Raviña, Eva Cubillo, David Olmeda, Ramón Novoa-Carballal and Eduardo Fernandez-Megia, et al. |
| 2556-2568 | Enhanced Gene and siRNA Delivery by Polycation-Modified Mesoporous Silica Nanoparticles Loaded with Chloroquine | Shanta Raj Bhattarai, Elayaraja Muthuswamy, Amit Wani, Michal Brichacek and Antonio L. Castañeda, et al. |
| 2569-2589 | Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release | Chris Oerlemans, Wouter Bult, Mariska Bos, Gert Storm and J. Frank W. Nijsen, et al. |
| 2590-2601 | Bioequivalence for Topical Products—An Update | Yogeeta Narkar |
| 2602-2613 | Influence of Dosing Schedule on Organ Exposure to Cyclosporin in Pediatric Hematopoietic Stem Cell Transplantation: Analysis with a PBPK Model | Cécile Gérard, Nathalie Bleyzac, Pascal Girard, Gilles Freyer and Yves Bertrand, et al. |
| 2614-2623 | Real-Time UV Imaging of Nicotine Release from Transdermal Patch | Jesper Østergaard, Emil Meng-Lund, Susan Weng Larsen, Claus Larsen and Karsten Petersson, et al. |
| 2624-2632 | Structural Interpretation in Composite Systems Using Powder X-ray Diffraction: Applications of Error Propagation to the Pair Distribution Function | Michael D. Moore, Zhenqi Shi and Peter L. D. Wildfong |
| 2633-2645 | Population Pharmacokinetic Analysis of Blood and Joint Synovial Fluid Concentrations of Robenacoxib from Healthy Dogs and Dogs with Osteoarthritis | Hanna E. Silber, Claudia Burgener, Ingrid M. Letellier, Mathieu Peyrou and Martin Jung, et al. |
| 2646-2656 | Predicting the Effect of Fed-State Intestinal Contents on Drug Dissolution | Ece Dilber Gamsiz, Mukul Ashtikar, John Crison, Walt Woltosz and Michael B. Bolger, et al. |
| 2657-2669 | Poly(ε-caprolactone)-Block-poly(ethyl Ethylene Phosphate) Micelles for Brain-Targeting Drug Delivery: In Vitro and In Vivo Valuation | Pengcheng Zhang, Luojuan Hu, Yucai Wang, Jun Wang and Linyin Feng, et al. |
| 2670-2682 | Amine-Modified Poly(Vinyl Alcohol)s as Non-viral Vectors for siRNA Delivery: Effects of the Degree of Amine Substitution on Physicochemical Properties and Knockdown Efficiency | Juliane Nguyen, Regina Reul, Susanne Roesler, Eyas Dayyoub and Thomas Schmehl, et al. |
| 2683-2693 | HPMA Copolymer-Aminohexylgeldanamycin Conjugates Targeting Cell Surface Expressed GRP78 in Prostate Cancer | Nate Larson, Abhijit Ray, Alexander Malugin, Daniel B. Pike and Hamidreza Ghandehari |
| 2694-2703 | In Vitro and In Vivo Anticancer Activity of a Novel Nano-sized Formulation Based on Self-assembling Polymers Against Pancreatic Cancer | Clare Hoskins, Mehdi Ouaissi, Sofia Costa Lima, Woei Ping Cheng and Inês Loureirio, et al. |
| 2704-2714 | Solubility Advantage of Amorphous Pharmaceuticals: II. Application of Quantitative Thermodynamic Relationships for Prediction of Solubility Enhancement in Structurally Diverse Insoluble Pharmaceuticals | Sharad B. Murdande, Michael J. Pikal, Ravi M. Shanker and Robin H. Bogner |
| 2715-2724 | Lipophilicity and Transporter Influence on Blood-Retinal Barrier Permeability: A Comparison with Blood-Brain Barrier Permeability | Ken-ichi Hosoya, Atsushi Yamamoto, Shin-ichi Akanuma and Masanori Tachikawa |
| 2725-2733 | Cocrystalization and Simultaneous Agglomeration Using Hot Melt Extrusion | Ravindra S. Dhumal, Adrian L. Kelly, Peter York, Phil D. Coates and Anant Paradkar |
| 2734-2742 | Topical Delivery of a Naproxen-Dithranol Co-drug: In Vitro Skin Penetration, Permeation, and Staining | Wing Man Lau, Alex W White and Charles M Heard |
| 2743-2752 | Anticancer Drug-Loaded Nanospheres Based on Biodegradable Amphiphilic ε-Caprolactone and Carbonate Copolymers | Guo-Ping Yan, Rong-Feng Zong, Liang Li, Ting Fu and Fan Liu, et al. |
| 2753-2765 | Delivery of Water-Soluble Drugs Using Acoustically Triggered Perfluorocarbon Double Emulsions | Mario L. Fabiilli, James A. Lee, Oliver D. Kripfgans, Paul L. Carson and J. Brian Fowlkes |
| 2766-2775 | Differential Response of Normal (PrEC) and Cancerous Human Prostate Cells (PC-3) to Phenethyl Isothiocyanate-Mediated Changes in Expression of Antioxidant Defense Genes | Anna A. Powolny and Shivendra V. Singh |
| 2776-2780 | Quantitative Aspects of Intracellularly-Targeted Drug Delivery | David Stepensky |
| 2781-2783 | News |
| 1-6 | Microneedles for Drug Delivery | Gary W. Cleary |
| 7-21 | Two-Layered Dissolving Microneedles for Percutaneous Delivery of Peptide/Protein Drugs in Rats | Keizo Fukushima, Ayaka Ise, Hiromi Morita, Ryo Hasegawa and Yukako Ito, et al. |
| 22-30 | Transdermal Delivery of Macromolecules Using Solid-State Biodegradable Microstructures | Janet R. Wendorf, Esi B. Ghartey-Tagoe, Stephen C. Williams, Elena Enioutina and Parminder Singh, et al. |
| 31-40 | Rapid Intradermal Delivery of Liquid Formulations Using a Hollow Microstructured Array | Scott A. Burton, Chin-Yee Ng, Ryan Simmers, Craig Moeckly and David Brandwein, et al. |
| 41-57 | Design, Optimization and Characterisation of Polymeric Microneedle Arrays Prepared by a Novel Laser-Based Micromoulding Technique | Ryan F. Donnelly, Rita Majithiya, Thakur Raghu Raj Singh, Desmond I. J. Morrow and Martin J. Garland, et al. |
| 58-65 | Microneedles with Intrinsic Immunoadjuvant Properties: Microfabrication, Protein Stability, and Modulated Release | Alexander K. Andrianov, Alexander Marin and Daniel P. DeCollibus |
| 66-81 | In Vivo, In Situ Imaging of Microneedle Insertion into the Skin of Human Volunteers Using Optical Coherence Tomography | Siôn A. Coulman, James C. Birchall, Aneesh Alex, Marc Pearton and Bernd Hofer, et al. |
| 82-94 | Formation and Closure of Microchannels in Skin Following Microporation | Haripriya Kalluri and Ajay K. Banga |
| 95-106 | Microneedles in Clinical Practice–An Exploratory Study Into the Opinions of Healthcare Professionals and the Public | James C. Birchall, Rachel Clemo, Alexander Anstey and Dai N. John |
| 107-116 | Microneedle-Based Intradermal Delivery Enables Rapid Lymphatic Uptake and Distribution of Protein Drugs | Alfred J. Harvey, Scott A. Kaestner, Diane E. Sutter, Noel G. Harvey and John A. Mikszta, et al. |
| 117-123 | Enhanced Bioavailability of L-Carnitine After Painless Intradermal Delivery vs. Oral Administration in Rats | Suohui Zhang, Guangjiong Qin, Yan Wu, Yunhua Gao and Yuqin Qiu, et al. |
| 124-134 | Vehicle Composition Influence on the Microneedle-Enhanced Transdermal Flux of Naltrexone Hydrochloride | Mikolaj Milewski and Audra L. Stinchcomb |
| 135-144 | Stability Kinetics of Influenza Vaccine Coated onto Microneedles During Drying and Storage | Yeu-Chun Kim, Fu-Shi Quan, Richard W. Compans, Sang-Moo Kang and Mark R. Prausnitz |
| 145-158 | Transcutaneous Immunization Studies in Mice Using Diphtheria Toxoid-Loaded Vesicle Formulations and a Microneedle Array | Zhi Ding, Suzanne M. Bal, Stefan Romeijn, Gideon F. A. Kersten and Wim Jiskoot, et al. |
| 159-165 | Parathyroid Hormone (1-34)-Coated Microneedle Patch System: Clinical Pharmacokinetics and Pharmacodynamics for Treatment of Osteoporosis | Peter E. Daddona, James. A. Matriano, Jaap Mandema and Yuh-Fun Maa |
| 166-176 | Suprachoroidal Drug Delivery to the Back of the Eye Using Hollow Microneedles | Samirkumar R. Patel, Angela S. P. Lin, Henry F. Edelhauser and Mark R. Prausnitz |
| 177-179 | AAPS Connection  |
| 181-186 | Nanomedicine for Cancer Therapy | Mansoor M. Amiji |
| 187-199 | Clinical Developments in Nanotechnology for Cancer Therapy | Jeremy D. Heidel and Mark E. Davis |
| 200-214 | Cancer Immunotherapy and Nanomedicine | Wei-Yun Sheng and Leaf Huang |
| 215-236 | Nanoparticle Delivery Systems in Cancer Vaccines | Yogita Krishnamachari, Sean M. Geary, Caitlin D. Lemke and Aliasger K. Salem |
| 237-259 | Inorganic Nanoparticles in Cancer Therapy | Sanjib Bhattacharyya, Rachel A. Kudgus, Resham Bhattacharya and Priyabrata Mukherjee |
| 260-272 | Nanoparticles: A Promising Modality in the Treatment of Sarcomas | Michiro Susa, Lara Milane, Mansoor M. Amiji, Francis J. Hornicek and Zhenfeng Duan |
| 273-278 | Nanotechnology-Based Cancer Therapeutics—Promise and Challenge—Lessons Learned Through the NCI Alliance for Nanotechnology in Cancer | Dorothy Farrell, Krzysztof Ptak, Nicholas J. Panaro and Piotr Grodzinski |
| 279-291 | An Effective Strategy for the Synthesis of Biocompatible Gold Nanoparticles Using Cinnamon Phytochemicals for Phantom CT Imaging and Photoacoustic Detection of Cancerous Cells | Nripen Chanda, Ravi Shukla, Ajit Zambre, Swapna Mekapothula and Rajesh R. Kulkarni, et al. |
| 292-300 | Nanochannel Technology for Constant Delivery of Chemotherapeutics: Beyond Metronomic Administration | Alessandro Grattoni, Haifa Shen, Daniel Fine, Arturas Ziemys and Jaskaran S. Gill, et al. |
| 301-308 | Palmitoyl Ascorbate-Loaded Polymeric Micelles: Cancer Cell Targeting and Cytotoxicity | Rupa R. Sawant, Onkar Vaze, Gerard G. M. D’Souza, Karen Rockwell and Vladimir P. Torchilin |
| 309-321 | High Loading of Gentamicin in Bioadhesive PVM/MA Nanostructured Microparticles Using Compressed Carbon-Dioxide | Elisa Elizondo, Santiago Sala, Edurne Imbuluzqueta, David González and María J. Blanco-Prieto, et al. |
| 322-330 | Chemical Inhibitors of the Calcium Entry Channel TRPV6 | Christopher P. Landowski, Katrin A. Bolanz, Yoshiro Suzuki and Matthias A. Hediger |
| 331-336 | Evidence of Deep Percutaneous Penetration Associated with Anti-Inflammatory Activity of Topically Applied Helicteres gardneriana Extract: A Photoacoustic Spectroscopy Study | Juliana Oliveira de Melo, Franciana Pedrochi, Mauro L. Baesso, Luzmarina Hernandes and Maria Conceição T. Truiti, et al. |
| 337-363 | Physicochemical Selectivity of the BBB Microenvironment Governing Passive Diffusion—Matching with a Porcine Brain Lipid Extract Artificial Membrane Permeability Model | Oksana Tsinman, Konstantin Tsinman, Na Sun and Alex Avdeef |
| 364-373 | Influence of Temperature on Solvent-Mediated Anhydrate-to-Hydrate Transformation Kinetics | Haiyan Qu, Tommy Munk, Claus Cornett, Jian X. Wu and Johan P. Bøtker, et al. |
| 374-385 | The Effect of Crystallizing and Non-crystallizing Cosolutes on Succinate Buffer Crystallization and the Consequent pH Shift in Frozen Solutions | Prakash Sundaramurthi and Raj Suryanarayanan |
| 386-393 | Quality of Original and Biosimilar Epoetin Products | Vera Brinks, Andrea Hawe, Abdul H. H. Basmeleh, Liliana Joachin-Rodriguez and Rob Haselberg, et al. |
| 394-404 | A Semi-mechanistic Gastric Emptying Model for the Population Pharmacokinetic Analysis of Orally Administered Acetaminophen in Critically Ill Patients | Kayode Ogungbenro, Lakshmi Vasist, Robert Maclaren, George Dukes and Malcolm Young, et al. |
| 405-412 | Human NPC1L1 Expression is Positively Regulated by PPARα | Yuki Iwayanagi, Tappei Takada, Fumiya Tomura, Yoshihide Yamanashi and Tomohiro Terada, et al. |
| 413-416 | Application of Alpha7 Nicotinic Acetylcholine Receptor Agonists in Inflammatory Diseases: An Overview | Mario B. Marrero, Merouane Bencherif, Patrick M. Lippiello and Rudolf Lucas |
| 417-419 | AAPS Connection |
| 421-422 | Outstanding Reviewers of 2010 |
| 423-437 | Cholesterol as a Potential Target for Castration-Resistant Prostate Cancer | Alexis L. Twiddy, Carlos G. Leon and Kishor M. Wasan |
| 438-455 | Biomagnetic Methods: Technologies Applied to Pharmaceutical Research | Luciana A. Corá, Madileine F. Américo, Ricardo B. Oliveira, Cristina H. R. Serra and Oswaldo Baffa, et al. |
| 456-471 | In Vivo Methods to Study Uptake of Nanoparticles into the Brain | Inge van Rooy, Serpil Cakir-Tascioglu, Wim E. Hennink, Gert Storm and Raymond M. Schiffelers, et al. |
| 472-479 | Convection and Retro-Convection Enhanced Delivery: Some Theoretical Considerations Related to Drug Targeting | J. P. Michael Motion, Grace H. Huynh, Francis C. Szoka and Ronald A. Siegel |
| 480-483 | Application of Magnetic Nanoparticles in Pharmaceutical Sciences | Michał Piotr Marszałł |
| 484-489 | Counterfeit Medicines in Cambodia—Possible Causes | Mohiuddin Hussain Khan, Junko Okumura, Tey Sovannarith, Nam Nivanna and Hiroto Nagai, et al. |
| 490-493 | The Unique Potential for Noninvasive Imaging in Modernizing Drug Development and in Transforming Therapeutics: PET/MRI/MRS | Walter Wolf |
| 494-504 | Investigating the Effect of Polymeric Approaches on Circulation Time and Physical Properties of Nanobubbles | Lisa C. du Toit, Thirumala Govender, Viness Pillay, Yahya E. Choonara and Tetsuya Kodama |
| 505-516 | Establishing New Acceptance Limits for Dissolution Performance Verification of USPC Apparatus 1 and 2 Using USPC Prednisone Tablets Reference Standard | Anthony J. DeStefano, Walter W. Hauck, Erika S. Stippler, William E. Brown and Chensheng Li, et al. |
| 517-530 | A New In Situ Brain Perfusion Flow Correction Method for Lipophilic Drugs Based on the pH-Dependent Crone-Renkin Equation | Alex Avdeef and Na Sun |
| 531-539 | Links Between Cyclosporin Exposure in Tissues and Graft-Versus-Host Disease in Pediatric Bone Marrow Transplantation: Analysis by a PBPK Model | Cécile Gérard, Nathalie Bleyzac, Pascal Girard, Gilles Freyer and Yves Bertrand, et al. |
| 540-552 | The Use of Disaccharides in Inhibiting Enzymatic Activity Loss and Secondary Structure Changes in Freeze-Dried β-Galactosidase during Storage | Ville Petteri Heljo, Kirsi Jouppila, Timo Hatanpää and Anne M. Juppo |
| 553-562 | Incorporation of the TLR4 Agonist Monophosphoryl Lipid A Into the Bilayer of DDA/TDB Liposomes: Physico-Chemical Characterization and Induction of CD8+ T-Cell Responses In Vivo | Pernille Nordly, Else Marie Agger, Peter Andersen, Hanne Mørck Nielsen and Camilla Foged |
| 563-571 | Microsphere Preparation Using the Untoxic Solvent Glycofurol | Daniela Allhenn and Alf Lamprecht |
| 572-584 | Atomic Force Microscopy-Based Screening of Drug-Excipient Miscibility and Stability of Solid Dispersions | Matthias Eckhard Lauer, Olaf Grassmann, Monira Siam, Joseph Tardio and Laurence Jacob, et al. |
| 585-596 | Nanoparticulate Delivery System Targeted to Tumor Neovasculature for Combined Anticancer and Antiangiogenesis Therapy | Zhe Wang, Wai-Keung Chui and Paul C. Ho |
| 597-609 | Galbanic Acid Isolated from Ferula assafoetida Exerts In Vivo Anti-tumor Activity in Association with Anti-angiogenesis and Anti-proliferation | Kwan-Hyun Kim, Hyo-Jung Lee, Soo-Jin Jeong, Hyo-Jeong Lee and Eun-Ok Lee, et al. |
| 610-625 | Role of Organic Cation Transporter 1, OCT1 in the Pharmacokinetics and Toxicity of cis-Diammine(pyridine)chloroplatinum(II) and Oxaliplatin in Mice | Shuanglian Li, Ying Chen, Shuzhong Zhang, Swati S. More and Xiaozhu Huang, et al. |
| 626-639 | Accelerated Stability Studies for Moisture-Induced Aggregation of Tetanus Toxoid | Nishant Kumar Jain and Ipsita Roy |
| 640-646 | Molecular Interaction Fields (MIFs) to Predict Lipophilicity and ADME Profile of Antitumor Pt(II) Complexes | Giulia Caron, Mauro Ravera and Giuseppe Ermondi |
| 647-661 | A Smart Interface for Reliable Intradermal Injection and Infusion of High and Low Viscosity Solutions | Michael Vosseler, Michael Jugl and Roland Zengerle |
| 662-672 | A Novel Peptide Nanomedicine Against Acute Lung Injury: GLP-1 in Phospholipid Micelles | Sok Bee Lim, Israel Rubinstein, Ruxana T. Sadikot, James E. Artwohl and Hayat Önyüksel |
| 673-682 | Comparison Between Hot-Melt Extrusion and Spray-Drying for Manufacturing Solid Dispersions of the Graft Copolymer of Ethylene Glycol and Vinylalcohol | Sandra Guns, Aswin Dereymaker, Pieterjan Kayaert, Vincent Mathot and Johan A. Martens, et al. |
| 683-687 | Erratum: Changes in Gene Expression Pattern of Human Primary Macrophages Induced by Carbosilane Dendrimer 2G-NN16 | Rafael Gras, Luis Almonacid, Paula Ortega, Maria J. Serramia and Rafael Gomez, et al. |
| 688-689 | AAPS Connection |
| 691-693 | Nucleic Acid Drug Delivery and Targeting | Yoshinobu Takakura |
| 694-701 | Hydrodynamic Gene Delivery and Its Applications in Pharmaceutical Research | Barbara Bonamassa, Li Hai and Dexi Liu |
| 702-711 | Positive Correlation Between the Generation of Reactive Oxygen Species and Activation/Reactivation of Transgene Expression After Hydrodynamic Injections into Mice | Naomi Takiguchi, Yuki Takahashi, Makiya Nishikawa, Yuriko Matsui and Yasushi Fukuhara, et al. |
| 712-719 | Delivery of an Angiogenic Gene into Ischemic Muscle by Novel Bubble Liposomes Followed by Ultrasound Exposure | Yoichi Negishi, Keiko Matsuo, Yoko Endo-Takahashi, Kentaro Suzuki and Yuuki Matsuki, et al. |
| 720-730 | In Vivo Anti-Tumor Effect of Expressing p14ARF-TAT Using a FGF2-Targeted Cationic Lipid Vector | Guoqin Niu, Wouter H. P. Driessen, Sean M. Sullivan and Jeffrey A. Hughes |
| 731-741 | Poly(I:C)-Mediated Tumor Growth Suppression in EGF-Receptor Overexpressing Tumors Using EGF-Polyethylene Glycol-Linear Polyethylenimine as Carrier | David Schaffert, Melinda Kiss, Wolfgang Rödl, Alexei Shir and Alexander Levitzki, et al. |
| 742-751 | Evaluation of Osteoclastogenesis via NFκB Decoy/mannosylated Cationic Liposome-Mediated Inhibition of Pro-inflammatory Cytokine Production from Primary Cultured Macrophages | Thuy Duong Dinh, Yuriko Higuchi, Shigeru Kawakami, Fumiyoshi Yamashita and Mitsuru Hashida |
| 752-761 | GFAP Promoter-Driven RNA Interference on TGF-β1 to Treat Liver Fibrosis | Ningning Yang and Ram I. Mahato |
| 762-775 | Temozolomide-Based Dry Powder Formulations for Lung Tumor-Related Inhalation Treatment | Nathalie Wauthoz, Philippe Deleuze, Amandine Saumet, Christophe Duret and Robert Kiss, et al. |
| 776-787 | Actively Targeted Low-Dose Camptothecin as a Safe, Long-Acting, Disease-Modifying Nanomedicine for Rheumatoid Arthritis | Otilia May Yue Koo, Israel Rubinstein and Hayat Önyüksel |
| 788-796 | Formation of Protein Nano-Matrix Particles with Controlled Surface Architecture for Respiratory Drug Delivery | Philip Chi Lip Kwok, Amolnat Tunsirikongkon, William Glover and Hak-Kim Chan |
| 797-811 | Systematic Evaluation of the Descriptive and Predictive Performance of Paediatric Morphine Population Models | Elke H. J. Krekels, Johan G. C. van Hasselt, Dick Tibboel, Meindert Danhof and Catherijne A. J. Knibbe |
| 812-826 | Efficient Intracellular Gene Delivery Using the Formulation Composed of Poly (L-glutamic Acid) Grafted Polyethylenimine and Histone | Jingjing Deng, Yuting Wen, Cuifeng Wang, Shirong Pan and Huaiyu Gu, et al. |
| 827-838 | Difluorinated-Curcumin (CDF): A Novel Curcumin Analog is a Potent Inhibitor of Colon Cancer Stem-Like Cells | Shailender Singh Kanwar, Yingjie Yu, Jyoti Nautiyal, Bhaumik B. Patel and Subhash Padhye, et al. |
| 839-847 | Iontophoresis-Facilitated Delivery of Prednisolone through Throat Skin to the Trachea After Topical Application of its Succinate Salt | Hiroshi Ishii, Tsukasa Suzuki, Hiroaki Todo, Mitsuhiro Kamimura and Kenji Sugibayashi |
| 848-857 | The Role of the Transition Metal Copper and the Ionophore A23187 in the Development of Irinophore C™ | Nilesh Patankar, Malathi Anantha, Euan Ramsay, Dawn Waterhouse and Marcel Bally |
| 858-872 | Ingredients Tracking of Cosmetic Formulations in the Skin: A Confocal Raman Microscopy Investigation | Matthias Förster, Marie-Alexandrine Bolzinger, Delphine Ach, Gilles Montagnac and Stephanie Briançon |
| 873-885 | Frozen State Storage Instability of a Monoclonal Antibody: Aggregation as a Consequence of Trehalose Crystallization and Protein Unfolding | Satish K. Singh, Parag Kolhe, Anjali P. Mehta, Steven C. Chico and Alanta L. Lary, et al. |
| 886-896 | Uptake and Transport of Novel Amphiphilic Polyelectrolyte-Insulin Nanocomplexes by Caco-2 Cells—Towards Oral Insulin | Colin Thompson, Woei Ping Cheng, Pramod Gadad, Karen Skene and Mhairi Smith, et al. |
| 897-906 | Paclitaxel-Loaded Poly(n-butylcyanoacrylate) Nanoparticle Delivery System to Overcome Multidrug Resistance in Ovarian Cancer | Fei Ren, Ruda Chen, Ying Wang, Yabin Sun and Yaodong Jiang, et al. |
| 907-919 | New 4-Maleamic Acid and 4-Maleamide Peptidyl Chalcones as Potential Multitarget Drugs for Human Prostate Cancer | Juan Rodrigues, Claudia Abramjuk, Luis Vásquez, Neira Gamboa and José Domínguez, et al. |
| 920-933 | Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development | John den Engelsman, Patrick Garidel, Ronald Smulders, Hans Koll and Bryan Smith, et al. |
| 934-937 | The Phage Therapy Paradigm: Prêt-à-Porter or Sur-mesure? | Jean-Paul Pirnay, Daniel De Vos, Gilbert Verbeken, Maia Merabishvili and Nina Chanishvili, et al. |
| 938 | Erratum to: “Establishing New Acceptance Limits for Dissolution Performance Verification of USPC Apparatus 1 and 2 Using USPC Prednisone Tablets Reference Standard” | Anthony J. DeStefano, Walter W. Hauck, Erika S. Stippler, William E. Brown and Chensheng Li, et al. |
| 939-941 | AAPS Connection |
| 943-948 | The Rule of Five for Non-Oral Routes of Drug Delivery: Ophthalmic, Inhalation and Transdermal | Young Bin Choy and Mark R. Prausnitz |
| 949-961 | Coupling of Aggregation and Immunogenicity in Biotherapeutics: T- and B-Cell Immune Epitopes May Contain Aggregation-Prone Regions | Sandeep Kumar, Satish K. Singh, Xiaoling Wang, Bonita Rup and Davinder Gill |
| 962-977 | Lipophilicity and Its Relationship with Passive Drug Permeation | Xiangli Liu, Bernard Testa and Alfred Fahr |
| 978-985 | Nano-emulsions and Micro-emulsions: Clarifications of the Critical Differences | Nicolas Anton and Thierry F. Vandamme |
| 986-1012 | Progress Towards a Needle-Free Hepatitis B Vaccine | Filipa Lebre, Gerrit Borchard, Maria Conceição Pedroso de Lima and Olga Borges |
| 1013-1022 | Disulfide-Based Poly(amido amine)s for siRNA Delivery: Effects of Structure on siRNA Complexation, Cellular Uptake, Gene Silencing and Toxicity | Pieter Vader, Leonardus J. van der Aa, Johan F. J. Engbersen, Gert Storm and Raymond M. Schiffelers |
| 1023-1030 | Effects of Metabolic Acidosis on Expression Levels of Renal Drug Transporters | Arong Gaowa, Hideyuki Motohashi, Toshiya Katsura and Ken-ichi Inui |
| 1031-1040 | Influence of Acylation on the Adsorption of Insulin to Hydrophobic Surfaces | Charlotte Pinholt, Susanne Hostrup, Jens Thostrup Bukrinsky, Sven Frokjaer and Lene Jorgensen |
| 1041-1048 | Data Requirements for the Reliable Use of Atomic Pair Distribution Functions in Amorphous Pharmaceutical Fingerprinting | Timur Dykhne, Ryan Taylor, Alastair Florence and Simon J. L. Billinge |
| 1049-1064 | Contribution of Saccadic Motion to Intravitreal Drug Transport: Theoretical Analysis | Ram K. Balachandran and Victor H. Barocas |
| 1065-1073 | Magnetic Resonance Imaging and Image Analysis for Assessment of HPMC Matrix Tablets Structural Evolution in USP Apparatus 4 | Piotr Kulinowski, Przemysław Dorożyński, Anna Młynarczyk and Władysław P. Węglarz |
| 1074-1080 | Biomaterial-Based Vaccine Induces Regression of Established Intracranial Glioma in Rats | Omar A. Ali, Ed Doherty, William J. Bell, Tracie Fradet and Jebecka Hudak, et al. |
| 1081-1089 | Assessment of Pharmacologic Area Under the Curve When Baselines are Variable | Jeremy D. Scheff, Richard R. Almon, Debra C. DuBois, William J. Jusko and Ioannis P. Androulakis |
| 1090-1099 | 5,7-Dimethoxyflavone and Multiple Flavonoids in Combination Alter the ABCG2-Mediated Tissue Distribution of Mitoxantrone in Mice | Guohua An, Fang Wu and Marilyn E. Morris |
| 1100-1111 | Development of a Bayesian Forecasting Method for Warfarin Dose Individualisation | Daniel F. B. Wright and Stephen B. Duffull |
| 1112-1120 | Fluorescence Single Particle Tracking for the Characterization of Submicron Protein Aggregates in Biological Fluids and Complex Formulations | Vasco Filipe, Robert Poole, Marika Kutscher, Katrien Forier and Kevin Braeckmans, et al. |
| 1121-1130 | Development and In Vitro-In Vivo Evaluation of Polymeric Implants for Continuous Systemic Delivery of Curcumin | Shyam S. Bansal, Manicka V. Vadhanam and Ramesh C. Gupta |
| 1131-1143 | Antibody-Mediated “Universal” Osteoclast Targeting Platform using Calcitonin as a Model Drug | Madhuri Newa, Krishna Hari Bhandari, Lili Tang, Rohit Kalvapalle and Mavanur Suresh, et al. |
| 1144-1156 | In Vivo Bioequivalence and In Vitro Similarity Factor (f2) for Dissolution Profile Comparisons of Extended Release Formulations: How and When Do They Match? | John Z. Duan, Kareen Riviere and Patrick Marroum |
| 1157-1166 | Inhalable Sustained-Release Formulation of Glucagon: In Vitro Amyloidogenic and Inhalation Properties, and In Vivo Absorption and Bioactivity | Satomi Onoue, Kazuki Kuriyama, Atsushi Uchida, Takahiro Mizumoto and Shizuo Yamada |
| 1167-1178 | Octreotide-Modified Polymeric Micelles as Potential Carriers for Targeted Docetaxel Delivery to Somatostatin Receptor Overexpressing Tumor Cells | Yuan Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang and Qiang Zhang |
| 1179-1193 | A New Approach to Explore the Impact of Freeze-Thaw Cycling on Protein Structure: Hydrogen/Deuterium Exchange Mass Spectrometry (HX-MS) | Aming Zhang, Wei Qi, Satish K. Singh and Erik J. Fernandez |
| 1194-1210 | The Degradation of Polysorbates 20 and 80 and its Potential Impact on the Stability of Biotherapeutics | Ravuri S. K. Kishore, Sylvia Kiese, Stefan Fischer, Astrid Pappenberger and Ulla Grauschopf, et al. |
| 1211-1219 | Diclofenac Enables Prolonged Delivery of Naltrexone Through Microneedle-Treated Skin | Stan L. Banks, Kalpana S. Paudel, Nicole K. Brogden, Charles D. Loftin and Audra L. Stinchcomb |
| 1220-1223 | Bottom-Up Preparation Techniques for Nanocrystals of Lipophilic Drugs | Hans de Waard, Henderik W. Frijlink and Wouter L. J. Hinrichs |
| 1224-1228 | Sintered Microsphere Scaffolds for Controlled Release and Tissue Engineering | Xuetao Shi, Kai Su, Rohan R. Varshney, Yingjun Wang and Dong-An Wang |
| 1229-1232 | The Changing Face of the Rate Concept in Biopharmaceutical Sciences: From Classical to Fractal and Finally to Fractional | Aristides Dokoumetzidis and Panos Macheras |
| 1233-1235 | AAPS Connection |
| 1237-1240 | Delivery of Engineered Therapeutics and Medication | Dong-an Wang |
| 1241-1258 | Controlled Delivery Systems: From Pharmaceuticals to Cells and Genes | Elizabeth Rosado Balmayor, Helena Sepulveda Azevedo and Rui L. Reis |
| 1259-1272 | Bioactive Electrospun Scaffolds Delivering Growth Factors and Genes for Tissue Engineering Applications | Wei Ji, Yan Sun, Fang Yang, Jeroen J. J. P. van den Beucken and Mingwen Fan, et al. |
| 1273-1281 | Nano-Fibrous Tissue Engineering Scaffolds Capable of Growth Factor Delivery | Jiang Hu and Peter X. Ma |
| 1282-1293 | Controlled Release of IGF-1 and HGF from a Biodegradable Polyurethane Scaffold | Devin M. Nelson, Priya R. Baraniak, Zuwei Ma, Jianjun Guan and N. Scott Mason, et al. |
| 1294-1305 | Synthesis of Temperature-Responsive Dextran-MA/PNIPAAm Particles for Controlled Drug Delivery Using Superhydrophobic Surfaces | Ana Catarina Lima, Wenlong Song, Barbara Blanco-Fernandez, Carmen Alvarez-Lorenzo and João F. Mano |
| 1306-1316 | Porous EH and EH-PEG Scaffolds as Gene Delivery Vehicles to Skeletal Muscle | Erin E. Falco, Martha O. Wang, Joshua A. Thompson, Joshua M. Chetta and Diana M. Yoon, et al. |
| 1317-1327 | String-Like Micellar Nanoparticles Formed by Complexation of PEG-b-PPA and Plasmid DNA and Their Transfection Efficiency | Xuan Jiang, Derek Leong, Yong Ren, Zhiping Li and Michael S. Torbenson, et al. |
| 1328-1337 | Non-viral Delivery of Inductive and Suppressive Genes to Adipose-Derived Stem Cells for Osteogenic Differentiation | Anusuya Ramasubramanian, Stacey Shiigi, Gordon K. Lee and Fan Yang |
| 1338-1348 | Optimal Construction and Delivery of Dual-Functioning Lentiviral Vectors for Type I Collagen-Suppressed Chondrogenesis in Synovium-Derived Mesenchymal Stem Cells | Feng Zhang, Yongchang Yao, Ruijie Zhou, Kai Su and Fudiman Citra, et al. |
| 1349-1356 | Localized Delivery of Antisense Oligonucleotides by Cationic Hydrogel Suppresses TNF-α Expression and Endotoxin-Induced Osteolysis | Lei Dong, Zhen Huang, Xing Cai, Jiawei Xiang and Yi-An Zhu, et al. |
| 1357-1369 | Blocking IKKα Expression Inhibits Prostate Cancer Invasiveness | Rubi Mahato, Bin Qin and Kun Cheng |
| 1370-1384 | Controlled Release of Anti-inflammatory siRNA from Biodegradable Polymeric Microparticles Intended for Intra-articular Delivery to the Temporomandibular Joint | Paschalia M. Mountziaris, David C. Sing, Sue Anne Chew, Stephanie N. Tzouanas and E. Dennis Lehman, et al. |
| 1385-1394 | The Effect of Human Bone Marrow Stroma-Derived Heparan Sulfate on the Ex Vivo Expansion of Human Cord Blood Hematopoietic Stem Cells | Diah S. Bramono, David A. Rider, Sadasivam Murali, Victor Nurcombe and Simon M. Cool |
| 1395-1405 | Chondrogenic Priming Adipose-Mesenchymal Stem Cells for Cartilage Tissue Regeneration | Nathaniel S. Hwang, Sung Gap Im, Patrick B. Wu, David A. Bichara and Xing Zhao, et al. |
| 1406-1414 | Combination of Hyaluronic Acid Hydrogel Scaffold and PLGA Microspheres for Supporting Survival of Neural Stem Cells | Ying Wang, Yue Teng Wei, Zhao Hui Zu, Rong Kai Ju and Mu Yao Guo, et al. |
| 1415-1421 | Stability of a Therapeutic Layer of Immobilized Recombinant Human Tropoelastin on a Plasma-Activated Coated Surface | Anna Waterhouse, Daniel V. Bax, Steven G. Wise, Yongbai Yin and Louise L. Dunn, et al. |
| 1422-1430 | Influence of Physical Properties of Biomaterials on Cellular Behavior | Susan Lin, Nivedita Sangaj, Tojo Razafiarison, Chao Zhang and Shyni Varghese |
| 1431-1441 | A Novel Shell-Structure Cell Microcarrier (SSCM) for Cell Transplantation and Bone Regeneration Medicine | Kai Su, Yihong Gong, Chunming Wang and Dong-An Wang |
| 1442-1444 | AAPS Connection |
| 1445-1453 | Pharmaceutical Equivalence by Design for Generic Drugs: Modified-Release Products | André Sirota Raw, Robert Lionberger and Lawrence X. Yu |
| 1454-1459 | The Alabama Drug Discovery Alliance: A Collaborative Partnership to Facilitate Academic Drug Discovery | Maaike Everts, W. Blaine Knight, David R. Harris, John A. Secrist and Richard J. Whitley |
| 1460-1464 | Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development | Piet H. van der Graaf and Neil Benson |
| 1465-1479 | Statistical Thinking and Knowledge Management for Quality-Driven Design and Manufacturing in Pharmaceuticals | Evdokia Korakianiti and Dimitrios Rekkas |
| 1480-1499 | Protein Microarrays: Novel Developments and Applications | Luis Berrade, Angie E. Garcia and Julio A. Camarero |
| 1500-1519 | Designing Dendrimers for Drug Delivery and Imaging: Pharmacokinetic Considerations | Wassana Wijagkanalan, Shigeru Kawakami and Mitsuru Hashida |
| 1520-1530 | Agarose Surface Coating Influences Intracellular Accumulation and Enhances Payload Stability of a Nano-delivery System | Enrica De Rosa, Ciro Chiappini, Dongmei Fan, Xuewu Liu and Mauro Ferrari, et al. |
| 1531-1539 | Effects of Food on a Gastrically Degraded Drug: Azithromycin Fast-Dissolving Gelatin Capsules and HPMC Capsules | William Curatolo, Ping Liu, Barbara A. Johnson, Angela Hausberger and Ernest Quan, et al. |
| 1540-1551 | The Effect of Composition and Gastric Conditions on the Self-Emulsification Process of Ibuprofen-Loaded Self-Emulsifying Drug Delivery Systems: A Microscopic and Dynamic Gastric Model Study | Annalisa Mercuri, Antonio Passalacqua, Martin S. J. Wickham, Richard M. Faulks and Duncan Q. M. Craig, et al. |
| 1552-1560 | Effect of Sugar Molecules on the Viscosity of High Concentration Monoclonal Antibody Solutions | Feng He, Christopher E. Woods, Jennifer R. Litowski, Lauren A. Roschen and Himanshu S. Gadgil, et al. |
| 1561-1576 | Pharmacokinetic-Pharmacodynamic Modeling of the Inhibitory Effects of Naproxen on the Time-Courses of Inflammatory Pain, Fever, and the Ex Vivo Synthesis of TXB2 and PGE2 in Rats | Elke H. J. Krekels, Marie Angesjö, Ingemo Sjögren, Kristina Ängeby Möller and Odd-Geir Berge, et al. |
| 1577-1590 | Effective Gene Delivery to Mesenchymal Stem Cells Based on the Reverse Transfection and Three-Dimensional Cell Culture System | Cai-Xia He, Ni Li, Yu-Lan Hu, Xiu-Mei Zhu and Hai-Jie Li, et al. |
| 1591-1605 | High-Throughput Screening of Excipients Intended to Prevent Antigen Aggregation at Air-Liquid Interface | Sébastien Dasnoy, Nancy Dezutter, Dominique Lemoine, Vivien Le Bras and Véronique Préat |
| 1606-1621 | Population Pharmacokinetic Modeling of trans-Resveratrol and Its Glucuronide and Sulfate Conjugates After Oral and Intravenous Administration in Rats | Helena Colom, Irene Alfaras, Mònica Maijó, M. Emília Juan and Joana M. Planas |
| 1622-1630 | Pharmacokinetic-Pharmacodynamic Disease Progression Model for Effect of Etanercept in Lewis Rats with Collagen-Induced Arthritis | Hoi-Kei Lon, Dongyang Liu, Qi Zhang, Debra C. DuBois and Richard R. Almon, et al. |
| 1631-1642 | “Click” Conjugation of Peptide on the Surface of Polymeric Nanoparticles for Targeting Tumor Angiogenesis | Stéphanie Deshayes, Victor Maurizot, Marie-Claude Clochard, Cécile Baudin and Thomas Berthelot, et al. |
| 1643-1652 | Influence of Particle Size on the Ultraviolet Spectrum of Particulate-Containing Solutions: Implications for In-Situ Concentration Monitoring Using UV/Vis Fiber-Optic Probes | Bernard Van Eerdenbrugh, David E. Alonzo and Lynne S. Taylor |
| 1653-1660 | Antitumour Efficacy of Two Paclitaxel Formulations for Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in an In Vivo Rat Model | Wim Bouquet, Steven Deleye, Steven Staelens, Lieselotte De Smet and Nancy Van Damme, et al. |
| 1661-1667 | O-Linked Glycosylation Leads to Decreased Thermal Stability of Interferon Alpha 2b as Measured by Two Orthogonal Techniques | Michael James Wilson Johnston, Grant Frahm, Xuguang Li, Yves Durocher and Mary Alice Hefford |
| 1668-1682 | Surface Characterisation of Bioadhesive PLGA/Chitosan Microparticles Produced by Supercritical Fluid Technology | Luca Casettari, Enzo Castagnino, Snjezana Stolnik, Andrew Lewis and Steven M. Howdle, et al. |
| 1683-1695 | Microemulsion Microstructure Influences the Skin Delivery of an Hydrophilic Drug | Wafa Naoui, Marie-Alexandrine Bolzinger, Bernard Fenet, Jocelyne Pelletier and Jean-Pierre Valour, et al. |
| 1696-1706 | Complex Pharmacokinetics of a Humanized Antibody Against Human Amyloid Beta Peptide, Anti-Abeta Ab2, in Nonclinical Species | Yulia Vugmeyster, Pam Szklut, David Wensel, John Ross and Xin Xu, et al. |
| 1707-1722 | DNA Nuclear Targeting Sequences for Non-Viral Gene Delivery | Ethlinn V. B. van Gaal, Ronald S. Oosting, Roel van Eijk, Marta Bakowska and Dries Feyen, et al. |
| 1723-1732 | Enhanced Stability and Knockdown Efficiency of Poly(ethylene glycol)-b-polyphosphoramidate/siRNA Micellar Nanoparticles by Co-condensation with Sodium Triphosphate | Masataka Nakanishi, Rajesh Patil, Yong Ren, Rishab Shyam and Philip Wong, et al. |
| 1733-1749 | PLGA Microparticles Encapsulating Prostaglandin E1-Hydroxypropyl-β-cyclodextrin (PGE1-HPβCD) Complex for the Treatment of Pulmonary Arterial Hypertension (PAH) | Vivek Gupta, Marauo Davis, Louisa J. Hope-Weeks and Fakhrul Ahsan |
| 1750-1764 | Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies | Sandeep Yadav, Alavattam Sreedhara, Sonoko Kanai, Jun Liu and Samantha Lien, et al. |
| 1765-1773 | Lyophilization of Protein-Loaded Polyelectrolyte Microcapsules | Marie-Luce De Temmerman, Joanna Rejman, Johan Grooten, Thomas De Beer and Chris Vervaet, et al. |
| 1774-1778 | The BCS, BDDCS, and Regulatory Guidances | Mei-Ling Chen, Gordon L. Amidon, Leslie Z. Benet, Hans Lennernas and Lawrence X. Yu |
| 1779-1781 | The Evolution of the Manufacturing Science and the Pharmaceutical Industry | Stavros N. Politis and Dimitrios M. Rekkas |
| 1782-1784 | News |
| 1785-1791 | Finding Promiscuous Old Drugs for New Uses | Sean Ekins and Antony J. Williams |
| 1792-1818 | Current and Future Drug Targets in Weight Management | Renger F. Witkamp |
| 1819-1830 | Intratumoral Drug Delivery with Nanoparticulate Carriers | Hillary Holback and Yoon Yeo |
| 1831-1842 | Effects of Surfactants on Lipase Structure, Activity, and Inhibition | Vincent Delorme, Rabeb Dhouib, Stéphane Canaan, Frédéric Fotiadu and Frédéric Carrière, et al. |
| 1843-1858 | Barriers to Non-Viral Vector-Mediated Gene Delivery in the Nervous System | Francisco C. Pérez-Martínez, Javier Guerra, Inmaculada Posadas and Valentín Ceña |
| 1859-1869 | Validating New Tuberculosis Computational Models with Public Whole Cell Screening Aerobic Activity Datasets | Sean Ekins and Joel S. Freundlich |
| 1870-1883 | Enhanced Oral Bioavailability of Vinpocetine Through Mechanochemical Salt Formation: Physico-Chemical Characterization and In Vivo Studies | Dritan Hasa, Dario Voinovich, Beatrice Perissutti, Mario Grassi and Alois Bonifacio, et al. |
| 1884-1894 | Aggregation Stability of a Monoclonal Antibody During Downstream Processing | Paolo Arosio, Giuliano Barolo, Thomas Müller-Späth, Hua Wu and Massimo Morbidelli |
| 1895-1904 | Effect of Formulation- and Administration-Related Variables on Deposition Pattern of Nasal Spray Pumps Evaluated Using a Nasal Cast | Vipra Kundoor and Richard N. Dalby |
| 1905-1918 | Regioselective Glucuronidation of Flavonols by Six Human UGT1A Isoforms | Baojian Wu, Beibei Xu and Ming Hu |
| 1919-1930 | Laser-Engineered Dissolving Microneedle Arrays for Transdermal Macromolecular Drug Delivery | Katarzyna Migalska, Desmond I. J. Morrow, Martin J. Garland, Raj Thakur and A. David Woolfson, et al. |
| 1931-1938 | Investigation of the Pharmacokinetics of Romiplostim in Rodents with a Focus on the Clearance Mechanism | Yow-Ming C. Wang, Bethlyn Sloey, Teresa Wong, Prerna Khandelwal and Rebeca Melara, et al. |
| 1939-1947 | Using Partial Area for Evaluation of Bioavailability and Bioequivalence | Mei-Ling Chen, Barbara Davit, Robert Lionberger, Zakaria Wahba and Hae-Young Ahn, et al. |
| 1948-1962 | A New Exact Test for the Evaluation of Population Pharmacokinetic and/or Pharmacodynamic Models Using Random Projections | Celine Marielle Laffont and Didier Concordet |
| 1963-1972 | Clinical Relevance of Liquid Chromatography Tandem Mass Spectrometry as an Analytical Method in Microdose Clinical Studies | Naoe Yamane, Zenzaburo Tozuka, Makiko Kusama, Kazuya Maeda and Toshihiko Ikeda, et al. |
| 1973-1983 | Viscosity Analysis of High Concentration Bovine Serum Albumin Aqueous Solutions | Sandeep Yadav, Steven J. Shire and Devendra S. Kalonia |
| 1984-1994 | Poly(Lactide-co-Glycolide) Nanocapsules Containing Benzocaine: Influence of the Composition of the Oily Nucleus on Physico-Chemical Properties and Anesthetic Activity | Nathalie Ferreira Silva de Melo, Renato Grillo, Viviane Aparecida Guilherme, Daniele Ribeiro de Araujo and Eneida de Paula, et al. |
| 1995-2007 | How Stealthy are PEG-PLA Nanoparticles? An NIR In Vivo Study Combined with Detailed Size Measurements | Andreas Schädlich, Cornelia Rose, Judith Kuntsche, Henrike Caysa and Thomas Mueller, et al. |
| 2008-2019 | Albumin-Coated Porous Hollow Poly(Lactic-co-Glycolic Acid) Microparticles Bound with Palmityl-Acylated Exendin-4 as a Long-Acting Inhalation Delivery System for the Treatment of Diabetes | Hyunuk Kim, Juho Lee, Tae Hyung Kim, Eun Seong Lee and Kyung Taek Oh, et al. |
| 2020-2033 | Formulation, Biological and Pharmacokinetic Studies of Sucrose Ester-Stabilized Nanosuspensions of Oleanolic Acid | Wenji Li, Surajit Das, Ka-yun Ng and Paul W. S. Heng |
| 2034-2044 | The Role of Constitutive Androstane Receptor in Oxazaphosphorine-Mediated Induction of Drug-Metabolizing Enzymes in Human Hepatocytes | Duan Wang, Linhao Li, Jennifer Fuhrman, Stephen Ferguson and Hongbing Wang |
| 2045-2054 | Increased Liver Uptake and Reduced Hepatic Stellate Cell Activation with a Cell-Specific Conjugate of the Rho-kinase Inhibitor Y27632 | Marike Marjolijn van Beuge, Jai Prakash, Marie Lacombe, Eduard Post and Catharina Reker-Smit, et al. |
| 2055-2057 | 2011 AAPS Annual Meeting and Exposition KEYNOTE SPEAKER |
| 2059-2071 | Interdisciplinary Science and the Design of a Single-Dose Antibiotic Therapy | William Curatolo |
| 2072-2085 | Self-Assembled and Nanostructured siRNA Delivery Systems | Ji Hoon Jeong, Tae Gwan Park and Sun Hwa Kim |
| 2086-2097 | Poly(Glycerol Adipate-co-ω-Pentadecalactone) Spray-Dried Microparticles as Sustained Release Carriers for Pulmonary Delivery | Hesham Tawfeek, Sayed Khidr, Eman Samy, Sayed Ahmed and Mark Murphy, et al. |
| 2098-2109 | Mesenchymal Stem Cells as a Gene Delivery Vehicle for Successful Islet Transplantation | Hao Wu, Wenli Lu and Ram I. Mahato |
| 2110-2118 | Transdermal Insulin Delivery Using Microdermabrasion | Samantha Andrews, Jeong Woo Lee, Seong-O Choi and Mark R. Prausnitz |
| 2119-2129 | Modelling Dermal Drug Distribution After Topical Application in Human | Yuri G. Anissimov and Michael Stephen Roberts |
| 2130-2139 | Cell-Penetrating Peptide-Modified Block Copolymer Micelles Promote Direct Brain Delivery via Intranasal Administration | Takanori Kanazawa, Hiroyuki Taki, Ko Tanaka, Yuuki Takashima and Hiroaki Okada |
| 2140-2146 | A Novel Method for the Investigation of Liquid/Liquid Distribution Coefficients and Interface Permeabilities Applied to the Water-Octanol-Drug System | Paul C. Stein, Massimiliano di Cagno and Annette Bauer-Brandl |
| 2147-2156 | The Airways, a Novel Route for Delivering Monoclonal Antibodies to Treat Lung Tumors | Agnès Maillet, Laurent Guilleminault, Etienne Lemarié, Stéphanie Lerondel and Nicolas Azzopardi, et al. |
| 2157-2164 | Insulin Lung Deposition and Clearance Following Technosphere® Insulin Inhalation Powder Administration | James P. Cassidy, Nikhil Amin, Mark Marino, Mark Gotfried and Thomas Meyer, et al. |
| 2165-2175 | Assessment of Topical Bioequivalence Using Dermal Microdialysis and Tape Stripping Methods | Tuba Incecayir, Ilbeyi Agabeyoglu, Ulver Derici and Sukru Sindel |
| 2176-2190 | Fatty Acid Binding Proteins: Potential Chaperones of Cytosolic Drug Transport in the Enterocyte? | Natalie L. Trevaskis, Gary Nguyen, Martin J. Scanlon and Christopher J. H. Porter |
| 2191-2203 | Molecular Motions in Sucrose-PVP and Sucrose-Sorbitol Dispersions: I. Implications of Global and Local Mobility on Stability | Sisir Bhattacharya and Raj Suryanarayanan |
| 2204-2222 | Turbidity Spectroscopy for Characterization of Submicroscopic Drug Carriers, Such as Nanoparticles and Lipid Vesicles: Size Determination | Mustafa M. A. Elsayed and Gregor Cevc |
| 2223-2232 | PEGylation Improves Nanoparticle Formation and Transfection Efficiency of Messenger RNA | Senta Üzgün, Gabriela Nica, Corinna Pfeifer, Michele Bosinco and Kai Michaelis, et al. |
| 2233-2245 | The Effect of Liposome Encapsulation on the Pharmacokinetics of Recombinant Secretory Leukocyte Protease Inhibitor (rSLPI) Therapy after Local Delivery to a Guinea Pig Asthma Model | Aileen Gibbons, Danielle Padilla-Carlin, Ciara Kelly, Anthony J. Hickey and Clifford Taggart, et al. |
| 2246-2260 | Structure-Skin Permeability Relationship of Dendrimers | Venkata Vamsi Venuganti, Preety Sahdev, Michael Hildreth, Xiangming Guan and Omathanu Perumal |
| 2261-2272 | Targeted Delivery to Neuroblastoma of Novel siRNA-anti-GD2-liposomes Prepared by Dual Asymmetric Centrifugation and Sterol-Based Post-Insertion Method | Joanna E. Adrian, Alexander Wolf, Annette Steinbach, Jochen Rössler and Regine Süss |
| 2273-2287 | Silica-Lipid Hybrid (SLH) Versus Non-lipid Formulations for Optimising the Dose-Dependent Oral Absorption of Celecoxib | Angel Tan, Andrew K. Davey and Clive A. Prestidge |
| 2288-2301 | Activation of Antigen-Specific T Cell-Responses by Mannan-Decorated PLGA Nanoparticles | Samar Hamdy, Azita Haddadi, Anooshirvan Shayeganpour, John Samuel and Afsaneh Lavasanifar |
| 2302-2310 | Taylor Dispersion Analysis Compared to Dynamic Light Scattering for the Size Analysis of Therapeutic Peptides and Proteins and Their Aggregates | Andrea Hawe, Wendy L. Hulse, Wim Jiskoot and Robert T. Forbes |
| 2311-2326 | Compositional Analysis of Low Quantities of Phase Separation in Hot-Melt-Extruded Solid Dispersions: A Combined Atomic Force Microscopy, Photothermal Fourier-Transform Infrared Microspectroscopy, and Localised Thermal Analysis Approach | Sheng Qi, Peter Belton, Kathrin Nollenberger, Andreas Gryczke and Duncan Q. M. Craig |
| 2327-2338 | Epithelial Profiling of Antibiotic Controlled Release Respiratory Formulations | Hui Xin Ong, Daniela Traini, Mary Bebawy and Paul Michael Young |
| 2339-2349 | Design of Dry Nanosuspension with Highly Spontaneous Dispersible Characteristics to Develop Solubilized Formulation for Poorly Water-Soluble Drugs | Toshiyuki Niwa, Satoru Miura and Kazumi Danjo |
| 2350-2352 | News |
| 2353-2378 | Controlled Release Systems Containing Solid Dispersions: Strategies and Mechanisms | Phuong Ha-Lien Tran, Thao Truong-Dinh Tran, Jun Bom Park and Beom-Jin Lee |
| 2379-2385 | Immunogenicity of Therapeutic Proteins: The Use of Animal Models | Vera Brinks, Wim Jiskoot and Huub Schellekens |
| 2386-2392 | Preparation of Personalized-dose Salbutamol Sulphate Oral Films with Thermal Ink-Jet Printing | Asma B. M. Buanz, Mark H. Saunders, Abdul W. Basit and Simon Gaisford |
| 2393-2402 | Oxidized and Aggregated Recombinant Human Interferon Beta is Immunogenic in Human Interferon Beta Transgenic Mice | Miranda M. C. van Beers, Melody Sauerborn, Francesca Gilli, Vera Brinks and Huub Schellekens, et al. |
| 2403-2411 | Intact Nanoparticulate Indomethacin in Fast-Dissolving Carrier Particles by Combined Wet Milling and Aerosol Flow Reactor Methods | Timo Laaksonen, Peng Liu, Antti Rahikkala, Leena Peltonen and Esko I. Kauppinen, et al. |
| 2412-2421 | Multivalent and Flexible PEG-Nitrilotriacetic Acid Derivatives for Non-covalent Protein Pegylation | Anna Mero, Tetsuya Ishino, Irwin Chaiken, Francesco M. Veronese and Gianfranco Pasut |
| 2422-2434 | Identification of a LNCaP-Specific Binding Peptide Using Phage Display | Bin Qin, Wanyi Tai, Ravi S. Shukla and Kun Cheng |
| 2435-2446 | Polymer Micelles with Hydrazone-Ester Dual Linkers for Tunable Release of Dexamethasone | Melissa D. Howard, Andrei Ponta, Allison Eckman, Michael Jay and Younsoo Bae |
| 2447-2457 | Theoretical Analysis of Interplay of Therapeutic Protein Drug and Circulating Soluble Target: Temporal Profiles of ‘Free’ and ‘Total’ Drug and Target | Cuyue Tang and Thomayant Prueksaritanont |
| 2458-2466 | Crystallization of Organic Glasses: Effects of Polymer Additives on Bulk and Surface Crystal Growth in Amorphous Nifedipine | Ting Cai, Lei Zhu and Lian Yu |
| 2467-2476 | PPARα Is Regulated by miR-21 and miR-27b in Human Liver | Katsuhiko Kida, Miki Nakajima, Takuya Mohri, Yuki Oda and Shingo Takagi, et al. |
| 2477-2489 | Stromal-Derived Factor-1 Alpha-Loaded PLGA Microspheres for Stem Cell Recruitment | Daisy P. Cross and Chun Wang |
| 2490-2504 | Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling of the Dopamine D2 Receptor Occupancy of Olanzapine in Rats | Martin Johnson, Magdalena Kozielska, Venkatesh Pilla Reddy, An Vermeulen and Cheryl Li, et al. |
| 2505-2515 | Assessment of P-glycoprotein Activity in the Blood-Brain Barrier (BBB) Using Near Infrared Fluorescence (NIRF) Imaging Techniques | Ngoc H. On, Fang Chen, Martha Hinton and Donald W. Miller |
| 2516-2529 | siRNA-Mediated Down-Regulation of P-glycoprotein in a Xenograft Tumor Model in NOD-SCID Mice | Meysam Abbasi, Hamidreza Montazeri Aliabadi, Elaine H. Moase, Afsaneh Lavasanifar and Kamaljit Kaur, et al. |
| 2530-2542 | Population PK and IgE Pharmacodynamic Analysis of a Fully Human Monoclonal Antibody Against IL4 Receptor | Tarundeep Kakkar, Cynthia Sung, Leonid Gibiansky, Thuy Vu and Adimoolam Narayanan, et al. |
| 2543-2555 | Site-Specific Tryptophan Oxidation Induced by Autocatalytic Reaction of Polysorbate 20 in Protein Formulation | Xanthe M. Lam, William G. Lai, Edwin K. Chan, Victor Ling and Chung C. Hsu |
| 2556-2566 | Spontaneous Gelation of a Novel Histamine H4 Receptor Antagonist in Aqueous Solution | Alexey Popov, Magali B. Hickey, Rupa Hiremath, Matthew Peterson and Poe Ratanabanangkoon, et al. |
| 2567-2574 | CLSM as Quantitative Method to Determine the Size of Drug Crystals in a Solid Dispersion | Hans de Waard, Martin J. T. Hessels, Maarten Boon, Klaas A. Sjollema and Wouter L. J. Hinrichs, et al. |
| 2575-2588 | Potential of Amino Acid/Dipeptide Monoester Prodrugs of Floxuridine in Facilitating Enhanced Delivery of Active Drug to Interior Sites of Tumors: A Two-Tier Monolayer In Vitro Study | Yasuhiro Tsume, John M. Hilfinger and Gordon L. Amidon |
| 2589-2598 | Using pH Abnormalities in Diseased Skin to Trigger and Target Topical Therapy | Khalida Rizi, Rebecca J. Green, Michael X. Donaldson and Adrian C. Williams |
| 2599-2609 | Development and In Vitro-In Vivo Evaluation of Fenretinide-Loaded Oral Mucoadhesive Patches for Site-Specific Chemoprevention of Oral Cancer | Kashappa-Goud H. Desai, Susan R. Mallery, Andrew S. Holpuch and Steven P. Schwendeman |
| 2610-2627 | Modeling Sleep Data for a New Drug in Development using Markov Mixed-Effects Models | Maria C. Kjellsson, Daniele Ouellet, Brian Corrigan and Mats O. Karlsson |
| 2628 | Erratum to: Opsonization, Biodistribution, Cellular Uptake and Apoptosis Study of PEGylated PBCA Nanoparticle as Potential Drug Delivery Carrier | Kiran Ramanlal Chaudhari, Mukesh Ukawala, Arehalli S. Manjappa, Abhinesh Kumar and Piyush Kishor Mundada, et al. |
| 2629-2631 | AAPS Connection |
| 2633-2638 | Mitochondrial Delivery of Biologically Active Molecules | Volkmar Weissig |
| 2639-2656 | Transduction of Human Recombinant Proteins into Mitochondria as a Protein Therapeutic Approach for Mitochondrial Disorders | Lefkothea C. Papadopoulou and Asterios S. Tsiftsoglou |
| 2657-2668 | From Serendipity to Mitochondria-Targeted Nanocarriers | Volkmar Weissig |
| 2669-2679 | Novel Therapies Targeting Inner Mitochondrial Membrane—From Discovery to Clinical Development | Hazel H. Szeto and Peter W. Schiller |
| 2680-2694 | Hormetics: Dietary Triggers of an Adaptive Stress Response | Marc Birringer |
| 2695-2730 | Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death | Stephen J. Ralph, Rafael Moreno-Sánchez, Jiri Neuzil and Sara Rodríguez-Enríquez |
| 2731-2744 | Mitochondrial Metabolism Inhibitors for Cancer Therapy | Emma E. Ramsay, Philip J. Hogg and Pierre J. Dilda |
| 2745-2757 | Quantitative Glucose and ATP Sensing in Mammalian Cells | Dania C. Liemburg-Apers, Hiromi Imamura, Marleen Forkink, Marco Nooteboom and Herman G. Swarts, et al. |
| 2758-2770 | Mitochondria and Trypanosomatids: Targets and Drugs | Lianet Monzote Fidalgo and Lars Gille |
| 2771-2779 | Strategies to Target Mitochondria and Oxidative Stress by Antioxidants: Key Points and Perspectives | Marvin Edeas |
| 2780-2789 | Multiple Triphenylphosphonium Cations as a Platform for the Delivery of a Pro-Apoptotic Peptide | Netanel Kolevzon, Uriel Kuflik, Miriam Shmuel, Sandrine Benhamron and Israel Ringel, et al. |
| 2790-2796 | The Utility of an Isolated Mitochondrial Fraction in the Preparation of Liposomes for the Specific Delivery of Bioactives to Mitochondria in Live Mammalian Cells | Mayura A. Wagle, Laura E. Martinville and Gerard G. M. D’Souza |
| 2797-2807 | Dimeric Cationic Amphiphilic Polyproline Helices for Mitochondrial Targeting | Iris M. Geisler and Jean Chmielewski |
| 2808-2819 | Development of Novel Peptides for Mitochondrial Drug Delivery: Amino Acids Featuring Delocalized Lipophilic Cations | Shana O. Kelley, Kelly M. Stewart and Rida Mourtada |
| 2820-2832 | New Fluorescent Probes Targeting the Mitochondrial-Located Translocator Protein 18 kDa (TSPO) as Activated Microglia Imaging Agents | Nunzio Denora, Valentino Laquintana, Adriana Trapani, Hiromi Suzuki and Makoto Sawada, et al. |
| 2833-2847 | Brain Mitochondrial Drug Delivery: Influence of Drug Physicochemical Properties | Shelley A. Durazo, Rajendra S. Kadam, Derek Drechsel, Manisha Patel and Uday B. Kompella |
| 2848-2862 | Expression of GFP in the Mitochondrial Compartment Using DQAsome-Mediated Delivery of an Artificial Mini-mitochondrial Genome | Diana Lyrawati, Alan Trounson and David Cram |
| 2863-2870 | Trial and Error: How the Unclonable Human Mitochondrial Genome was Cloned in Yeast | Brian W. Bigger, Ai-Yin Liao, Ana Sergijenko and Charles Coutelle |
| 2871-2882 | DNA Delivery to Mitochondria: Sequence Specificity and Energy Enhancement | Noha Ibrahim, Hirokazu Handa, Anne Cosset, Milana Koulintchenko and Yuri Konstantinov, et al. |
| 2883-2895 | Novel Mitochondria-Targeted Antioxidants: Plastoquinone Conjugated with Cationic Plant Alkaloids Berberine and Palmatine | Konstantin G. Lyamzaev, Antonina V. Pustovidko, Ruben A. Simonyan, Tatyana I. Rokitskaya and Lidia V. Domnina, et al. |
| 2896-2909 | An Acetate Prodrug of a Pyridinol-Based Vitamin E Analogue | Omar M. Khdour, Jun Lu and Sidney M. Hecht |
| 2910-2919 | Mitochondrial Antioxidants Alleviate Oxidative and Nitrosative Stress in a Cellular Model of Sepsis | Nadezda Apostolova, Remedios Garcia-Bou, Antonio Hernandez-Mijares, Raul Herance and Milagros Rocha, et al. |
| 2920-2930 | Time-Correlated Single Photon Counting For Simultaneous Monitoring Of Zinc Oxide Nanoparticles And NAD(P)H In Intact And Barrier-Disrupted Volunteer Skin | Lynlee L. Lin, Jeffrey E. Grice, Margaret K. Butler, Andrei V. Zvyagin and Wolfgang Becker, et al. |
| 2931-2944 | Gold Nanoparticle Penetration and Reduced Metabolism in Human Skin by Toluene | Hagar I. Labouta, David C. Liu, Lynlee L. Lin, Margaret K. Butler and Jeffrey E. Grice, et al. |
| 2945-2953 | Improvement of Cerebral Metabolism Mediated by Ro5-4864 is Associated with Relief of Intracranial Pressure and Mitochondrial Protective Effect in Experimental Brain Injury | Jean F. Soustiel, Eugene Vlodavsky, Felix Milman, Moshe Gavish and Menashe Zaaroor |
| 2954-2957 | A Clinician’s Commentary: Mitochondria and Revolution | Stephen P. Hersh |
| 2958-2960 | AAPS Connection |